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Enzyme Nomenclature
Information on EC 1.14.15.11 - pentalenic acid synthase
Word Map on EC 1.14.15.11
- 1.14.15.11
- avermitilis
- daidzein
- ferredoxins
- phenobarbital
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xenobiotic
- heme
- isoquinoline
- putida
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3'-position
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3'-hydroxylase
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putidaredoxin
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monooxygenase
- isoflavone
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host-plant
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race
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regiospecific
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insecticides
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The expected taxonomic range for this enzyme is: Streptomyces avermitilis
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EC NUMBER 
COMMENTARY 
1.14.15.11
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RECOMMENDED NAME
GeneOntology No.
pentalenic acid synthase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
1-deoxypentalenate + reduced ferredoxin + O2 = pentalenate + oxidized ferredoxin + H2O
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
1-deoxypentalenate,reduced ferredoxin:O2 oxidoreductase
A heme-thiolate enzyme (P-450). Isolated from the bacterium Streptomyces avermitilis. The product, pentalenate, is a co-metabolite from pentalenolactone biosynthesis.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
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disruption of the sav7469 gene encoding pentalenic acid synthase abolishes production of pentalenic acid. The deletion mutant accumulates 1-deoxypentalenic acid. Recombinant enzyme prepared from Escherichia coli catalyzes the oxidative conversion of 1-deoxypentalenic acid to pentalenic acid in the presence of the electron-transport partners, ferredoxin and ferredoxin reductase, both in vivo and in vitro
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-deoxypentalenic acid + reduced ferredoxin + O2
pentalenic acid + oxidized ferredoxin + H2O
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additional information
?
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enzyme additionally catalyzes the hydroxylation of daidzein to 7,3',4'-trihydroxyisoflavone with apparent Km and kcat values for daidzein of 21.83 mM and 15.01 per min in the presence of putidaredoxin and putidaredoxin reductase, respectively
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additional information
?
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no substrates: pentalenene, 1-deoxy-11beta-hydroxypentalenic acid, 1-deoxy-11-oxopentalenic acid, or the corresponding methyl esters of 1-deoxy-11beta-hydroxypentalenic acid, 1-deoxy-11-oxopentalenic acid and 1-deoxypentalenic acid, respectively
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additional information
?
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enzyme additionally catalyzes the hydroxylation of daidzein to 7,3',4'-trihydroxyisoflavone with apparent Km and kcat values for daidzein of 21.83 mM and 15.01 per min in the presence of putidaredoxin and putidaredoxin reductase, respectively
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PDB
SCOP
CATH
ORGANISM
UNIPROT
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.15.11)
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