Information on EC 1.14.14.34 - methanesulfonate monooxygenase (FMNH2)

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.14.14.34
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RECOMMENDED NAME
GeneOntology No.
methanesulfonate monooxygenase (FMNH2)
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
methanesulfonate + FMNH2 + O2 = formaldehyde + FMN + sulfite + H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
dimethyl sulfide degradation II (oxidation)
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SYSTEMATIC NAME
IUBMB Comments
methanesulfonate,FMNH2:oxygen oxidoreductase
The enzyme, characterized from Pseudomonas strains, allows the organisms to utilize methanesulfonate as their sulfur source. It acts in combination with a dedicated NADH-dependent FMN reductase (EC 1.5.1.42), which provides it with reduced FMN. cf. EC 1.14.13.111, methanesulfonate monooxygenase (NADH).
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ethanesulfonate + FMNH2 + O2
acetaldehyde + FMN + sulfite + H2O
show the reaction diagram
isethionate + FMNH2 + O2
hydroxyacetaldehyde + FMN + sulfite + H2O
show the reaction diagram
methanesulfonate + FMNH2 + O2
formaldehyde + FMN + sulfite + H2O
show the reaction diagram
morpholinepropanesulfonic acid + FMNH2 + O2
3-(morpholin-4-yl)propanal + FMN + sulfite + H2O
show the reaction diagram
pentanesulfonate + FMNH2 + O2
pentanal + FMN + sulfite + H2O
show the reaction diagram
piperazine-N,N'-bis(2-ethanesulfonic acid) + 2 FMNH2 + 2 O2
2,2'-piperazine-1,4-diyldiacetaldehyde + 2 FMN + 2 sulfite + 2 H2O
show the reaction diagram
31% of the activity with methanesulfonate
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additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
methanesulfonate + FMNH2 + O2
formaldehyde + FMN + sulfite + H2O
show the reaction diagram
pentanesulfonate + FMNH2 + O2
pentanal + FMN + sulfite + H2O
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
82900
substrate pentanesulfonate, pH 8.0, 30°C
121000
substrate methanesulfonate, pH 8.0, 30°C
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression of the msu operon is derepressed during growth with methionine or alkanesulfonates
expression of the msu operon is repressed in the presence of sulfate, sulfite, sulfide, or cysteine
growth with methanesulfonate requires an intact cysB gene, and the msu operon is part of the cys regulon