Reference on EC 1.14.14.25 - cholesterol 24-hydroxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mast, N.; Andersson, U.; Nakayama, K.; Bjorkhem, I.; Pikuleva, I.A.
Expression of human cytochrome P450 46A1 in Escherichia coli: effects of N- and C-terminal modifications
Arch. Biochem. Biophys.
428
99-108
2004
Homo sapiens
Mast, N.; Norcross, R.; Andersson, U.; Shou, M.; Nakayama, K.; Bjorkhem, I.; Pikuleva, I.A.
Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain
Biochemistry
42
14284-14292
2003
Homo sapiens
Russell, D.W.
Oxysterol biosynthetic enzymes
Biochim. Biophys. Acta
1529
126-135
2000
Mus musculus (Q9WVK8), Homo sapiens (Q9Y6A2)
Lund, E.G.; Xie, C.; Kotti, T.; Turley, S.D.; Dietschy, J.M.; Russell, D.W.
Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
J. Biol. Chem.
278
22980-22988
2003
Mus musculus
Brown, J.3rd.; Theisler, C.; Silberman, S.; Magnuson, D.; Gottardi-Littell, N.; Lee, J.M.; Yager, D.; Crowley, J.; Sambamurti, K.; Rahman, M.M.; Reiss, A.B.; Eckman, C.B.; Wolozin, B.
Differential expression of cholesterol hydroxylases in Alzheimer's disease
J. Biol. Chem.
279
34674-34681
2004
Homo sapiens
Ohyama, Y.; Meaney, S.; Heverin, M.; Ekstrom, L.; Brafman, A.; Shafir, M.; Andersson, U.; Olin, M.; Eggertsen, G.; Diczfalusy, U.; Feinstein, E.; Bjorkhem, I.
Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): Marked insensitivity towards different regulatory axes
J. Biol. Chem.
281
3810-3820
2006
Homo sapiens
Bogdanovic, N.; Bretillon, L.; Lund, E.G.; Diczfalusy, U.; Lannfelt, L.; Winblad, B.; Russell, D.W.; Bjorkhem, I.
On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells
Neurosci. Lett.
314
45-48
2001
Homo sapiens
Shibata, N.; Kawarai, T.; Lee, J.H.; Lee, H.S.; Shibata, E.; Sato, C.; Liang, Y.; Duara, R.; Mayeux, R.P.; St George-Hyslop, P.H.; Rogaeva, E.
Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease
Neurosci. Lett.
391
142-146
2006
Homo sapiens
Lund, E.G.; Guileyardo, J.M.; Russell, D.W.
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
Proc. Natl. Acad. Sci. USA
96
7238-7243
1999
Mus musculus (Q9WVK8), Mus musculus, Homo sapiens (Q9Y6A2), Homo sapiens
Luetjohann, D.
Cholesterol metabolism in the brain: importance of 24S-hydroxylation
Acta Neurol. Scand.
114 (Suppl. 185)
33-42
2006
Homo sapiens, Mus musculus, Sus scrofa
Pikuleva, I.A.
Cholesterol-metabolizing cytochromes P450
Drug Metab. Dispos.
34
513-520
2006
Homo sapiens
He, X.; Jenner, A.M.; Ong, W.Y.; Farooqui, A.A.; Patel, S.C.
Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury
J. Neuropathol. Exp. Neurol.
65
652-663
2006
Rattus norvegicus
Kotti, T.J.; Ramirez, D.M.; Pfeiffer, B.E.; Huber, K.M.; Russell, D.W.
Brain cholesterol turnover required for geranylgeraniol production and learning in mice
Proc. Natl. Acad. Sci. USA
103
3869-3874
2006
Mus musculus
Famer, D.; Meaney, S.; Mousavi, M.; Nordberg, A.; Bjoerkhem, I.; Crisby, M.
Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway
Biochem. Biophys. Res. Commun.
359
46-50
2007
Homo sapiens
Bretillon, L.; Diczfalusy, U.; Bjoerkhem, I.; Maire, M.A.; Martine, L.; Joffre, C.; Acar, N.; Bron, A.; Creuzot-Garcher, C.
Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina
Curr. Eye Res.
32
361-366
2007
Bos taurus, Rattus norvegicus
Ramirez, D.M.; Andersson, S.; Russell, D.W.
Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain
J. Comp. Neurol.
507
1676-1693
2008
Mus musculus
Cartagena, C.M.; Ahmed, F.; Burns, M.P.; Pajoohesh-Ganji, A.; Pak, D.T.; Faden, A.I.; Rebeck, G.W.
Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain
J. Neurotrauma
25
1087-1098
2008
Rattus norvegicus
Mast, N.; White, M.A.; Bjorkhem, I.; Johnson, E.F.; Stout, C.D.; Pikuleva, I.A.
Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain
Proc. Natl. Acad. Sci. USA
105
9546-9551
2008
Homo sapiens (Q9Y6A2)
Mast, N.; Liao, W.L.; Pikuleva, I.A.; Turko, I.V.
Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPH-cytochrome P450 oxidoreductase
Arch. Biochem. Biophys.
483
81-89
2009
Homo sapiens (Q9Y6A2), Homo sapiens
Fu, B.Y.; Ma, S.L.; Tang, N.L.; Tam, C.W.; Lui, V.W.; Chiu, H.F.; Lam, L.C.
Cholesterol 24-hydroxylase (CYP46A1) polymorphisms are associated with faster cognitive deterioration in Chinese older persons: a two-year follow up study
Int. J. Geriatr. Psychiatry
24
921-926
2009
Homo sapiens
Russell, D.W.; Halford, R.W.; Ramirez, D.M.; Shah, R.; Kotti, T.
Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain
Annu. Rev. Biochem.
78
1017-1040
2009
Bos taurus, Canis lupus familiaris, Cavia porcellus, Gallus gallus, Oryctolagus cuniculus, Equus caballus, Equus sp., Homo sapiens, Macaca mulatta, Mus musculus, Ornithorhynchus anatinus, Pan troglodytes, Rattus norvegicus, Danio rerio (A5WWJ0), Xenopus laevis (Q7SYY2)
Shafaati, M.; O'Driscoll, R.; Bjoerkhem, I.; Meaney, S.
Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors
Biochem. Biophys. Res. Commun.
378
689-694
2009
Homo sapiens, Mus musculus, Mus musculus C57B6-J
Koelsch, H.; Luetjohann, D.; Jessen, F.; Popp, J.; Hentschel, F.; Kelemen, P.; Schmitz, S.; Maier, W.; Heun, R.
CYP46A1 variants influence Alzheimers disease risk and brain cholesterol metabolism
Eur. Psychiatry
24
183-190
2009
Homo sapiens
Fourgeux, C.; Martine, L.; Bjoerkhem, I.; Diczfalusy, U.; Joffre, C.; Acar, N.; Creuzot-Garcher, C.; Bron, A.; Bretillon, L.
Primary open angle glaucoma: Association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and pPlasma 24-hydroxycholesterol levels
Invest. Ophthalmol. Vis. Sci.
50
5712-5717
2009
Homo sapiens
Shafaati, M.; Mast, N.; Beck, O.; Nayef, R.; Heo, G.Y.; Bjoerkhem-Bergman, L.; Lutjohann, D.; Bjoerkhem, I.; Pikuleva, I.A.
The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase (CYP46A1) in vitro and in vivo
J. Lipid Res.
51
318-323
2010
Homo sapiens, Mus musculus
Martin, M.G.; Perga, S.; Trovo, L.; Rasola, A.; Holm, P.; Rantamaeki, T.; Harkany, T.; Castren, E.; Chiara, F.; Dotti, C.G.
Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro
Mol. Biol. Cell
19
2101-2112
2008
Mus musculus, Rattus norvegicus
Hudry, E.; Van Dam, D.; Kulik, W.; De Deyn, P.P.; Stet, F.S.; Ahouansou, O.; Benraiss, A.; Delacourte, A.; Bougneres, P.; Aubourg, P.; Cartier, N.
Adeno-associated Virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimers disease
Mol. Ther.
18
44-53
2010
Homo sapiens, Mus musculus, Mus musculus APP23
Solomon, A.; Leoni, V.; Kivipelto, M.; Besga, A.; Oksengard, A.R.; Julin, P.; Svensson, L.; Wahlund, L.O.; Andreasen, N.; Winblad, B.; Soininen, H.; Bjoerkhem, I.
Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimers disease
Neurosci. Lett.
462
89-93
2009
Homo sapiens
Halford, R.W.; Russell, D.W.
Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimers disease, but does extend lifespan
Proc. Natl. Acad. Sci. USA
106
3502-3506
2009
Mus musculus
Cartagena, C.M.; Burns, M.P.; Rebeck, G.W.
24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury
Brain Res.
1319
1-12
2010
Homo sapiens
Smiljanic, K.; Lavrnja, I.; Mladenovic Djordjevic, A.; Ruzdijic, S.; Stojiljkovic, M.; Pekovic, S.; Kanazir, S.
Brain injury induces cholesterol 24-hydroxylase (Cyp46) expression in glial cells in a time-dependent manner
Histochem. Cell Biol.
134
159-169
2010
Rattus norvegicus, Rattus norvegicus Wistar
Tian, G.; Kong, Q.; Lai, L.; Ray-Chaudhury, A.; Lin, C.L.
Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimers disease
J. Neurochem.
113
978-989
2010
Homo sapiens
Liao, W.L.; Heo, G.Y.; Dodder, N.G.; Reem, R.E.; Mast, N.; Huang, S.; Dipatre, P.L.; Turko, I.V.; Pikuleva, I.A.
Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain
J. Proteome Res.
10
241-248
2011
Homo sapiens, Homo sapiens (Q9Y6A2)
Fourgeux, C.; Bron, A.; Acar, N.; Creuzot-Garcher, C.; Bretillon, L.
24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma
Chem. Phys. Lipids
164
496-499
2011
Homo sapiens
Maioli, S.; Bavner, A.; Ali, Z.; Heverin, M.; Ismail, M.A.; Puerta, E.; Olin, M.; Saeed, A.; Shafaati, M.; Parini, P.; Cedazo-Minguez, A.; Bjoerkhem, I.
Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain?
PLoS ONE
8
e68534
2013
Homo sapiens
Fourgeux, C.; Martine, L.; Acar, N.; Bron, A.M.; Creuzot-Garcher, C.P.; Bretillon, L.
In vivo consequences of cholesterol-24S-hydroxylase (CYP46A1) inhibition by voriconazole on cholesterol homeostasis and function in the rat retina
Biochem. Biophys. Res. Commun.
446
775-781
2014
Rattus norvegicus (F7EN52), Rattus norvegicus Wistar (F7EN52)
Boussicault, L.; Alves, S.; Lamaziere, A.; Planques, A.; Heck, N.; Moumne, L.; Despres, G.; Bolte, S.; Hu, A.; Pages, C.; Galvan, L.; Piguet, F.; Aubourg, P.; Cartier, N.; Caboche, J.; Betuing, S.
CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntingtons disease
Brain
139
953-970
2016
Homo sapiens (Q9Y6A2), Homo sapiens, Mus musculus (Q9WVK8), Mus musculus, Mus musculus C57BL/6 (Q9WVK8)
Uto, Y.
Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676)
Expert Opin. Ther. Pat.
25
373-377
2015
Homo sapiens (Q9Y6A2)
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