Reference on EC 1.14.14.24 - vitamin D 25-hydroxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rahmaniyan, M.; Patrick, K.; Bell, N.H.
Characterization of recombinant CYP2C11: a vitamin D 25-hydroxylase and 24-hydroxylase
Am. J. Physiol. Endocrinol. Metab.
288
E753-E760
2005
Rattus norvegicus (P08683)
Postlind, H.; Axen, E.; Bergman, T.; Wikvall, K.
Cloning, structure, and expression of a cDNA encoding vitamin D3 25-hydroxylase
Biochem. Biophys. Res. Commun.
241
491-497
1997
Sus scrofa
Hosseinpour, F.; Hidestrand, M.; Ingelman-Sundberg, M.; Wikvall, K.
The importance of residues in substrate recognition site 3 for the catalytic function of CYP2D25 (vitamin D 25-hydroxylase)
Biochem. Biophys. Res. Commun.
288
1059-1063
2001
Sus scrofa
Shinkyo, R.; Sakaki, T.; Kamakura, M.; Ohta, M.; Inouye, K.
Metabolism of vitamin D by human microsomal CYP2R1
Biochem. Biophys. Res. Commun.
324
451-457
2004
Homo sapiens
Fujii, Y.; Kabumoto, H.; Nishimura, K.; Fujii, T.; Yanai, S.; Takeda, K.; Tamura, N.; Arisawa, A.; Tamura, T.
Purification, characterization, and directed evolution study of a vitamin D3 hydroxylase from Pseudonocardia autotrophica
Biochem. Biophys. Res. Commun.
385
170-175
2009
Pseudonocardia autotrophica (C4B644), Pseudonocardia autotrophica NBRC 12743 (C4B644)
Saarem, K.; Pedersen, J.I.
25-Hydroxylation of 1 alpha-hydroxyvitamin D-3 in rat and human liver
Biochim. Biophys. Acta
840
117-126
1985
Rattus norvegicus
Axen, E.
Purification from pig kidney of a microsomal cytochrome P450 catalyzing 1 alpha-hydroxylation of 25-hydroxyvitamin D3
FEBS Lett.
375
277-279
1995
Sus scrofa
Masumoto, O.; Ohyama, Y.; Okuda, K.
Purification and characterization of vitamin D 25-hydroxylase from rat liver mitochondria
J. Biol. Chem.
263
14256-14260
1988
Rattus norvegicus
Cheng, J.B.; Motola, D.L.; Mangelsdorf, D.J.; Russell, D.W.
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase
J. Biol. Chem.
278
38084-38093
2003
Mus musculus (Q6VVW9)
Yamasaki, T.; Izumi, S.; Ide, H.; Ohyama, Y.
Identification of a novel rat microsomal vitamin D3 25-hydroxylase
J. Biol. Chem.
279
22848-22856
2004
Rattus norvegicus (P51590)
Kaufmann, M.; Prosser, D.E.; Jones, G.
Bioengineering anabolic vitamin D-25-hydroxylase activity into the human vitamin D catabolic enzyme, cytochrome P450 CYP24A1, by a V391L mutation
J. Biol. Chem.
286
28729-28737
2011
Homo sapiens (Q07973), Homo sapiens
Strushkevich, N.; Usanov, S.A.; Plotnikov, A.N.; Jones, G.; Park, H.W.
Structural analysis of CYP2R1 in complex with vitamin D3
J. Mol. Biol.
380
95-106
2008
Homo sapiens (Q6VVX0)
Cheng, J.B.; Levine, M.A.; Bell, N.H.; Mangelsdorf, D.J.; Russell, D.W.
Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase
Proc. Natl. Acad. Sci. USA
101
7711-7715
2004
Homo sapiens
Wang, Y.; Marling, S.J.; Zhu, J.G.; Severson, K.S.; DeLuca, H.F.
Development of experimental autoimmune encephalomyelitis (EAE) in mice requires vitamin D and the vitamin D receptor
Proc. Natl. Acad. Sci. USA
109
8501-8504
2012
Mus musculus
Aiba, I.; Yamasaki, T.; Shinki, T.; Izumi, S.; Yamamoto, K.; Yamada, S.; Terato, H.; Ide, H.; Ohyama, Y.
Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases
Steroids
71
849-856
2006
Homo sapiens (P51589), Homo sapiens, Rattus norvegicus (P51590)
Urbschat, A.; Paulus, P.; von Quernheim, Q.F.; Brueck, P.; Badenhoop, K.; Zeuzem, S.; Ramos-Lopez, E.
Vitamin D hydroxylases CYP2R1, CYP27B1 and CYP24A1 in renal cell carcinoma
Eur. J. Clin. Invest.
43
1282-1290
2013
Homo sapiens (Q6VVX0)
Foresta, C.; Strapazzon, G.; De Toni, L.; Perilli, L.; Di Mambro, A.; Muciaccia, B.; Sartori, L.; Selice, R.
Bone mineral density and testicular failure: evidence for a role of vitamin D 25-hydroxylase in human testis
J. Clin. Endocrinol. Metab.
96
E646-E652
2011
Homo sapiens (Q6VVX0), Homo sapiens
Nissen, J.; Vogel, U.; Ravn-Haren, G.; Andersen, E.W.; Madsen, K.H.; Nex?, B.A.; Andersen, R.; Mejborn, H.; Bjerrum, P.J.; Rasmussen, L.B.; Wulf, H.C.
Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D3-fortified bread and milk during winter in Denmark
Am. J. Clin. Nutr.
101
218-227
2015
Homo sapiens (Q6VVX0)
Yasuda, K.; Endo, M.; Ikushiro, S.; Kamakura, M.; Ohta, M.; Sakaki, T.
UV-dependent production of 25-hydroxyvitamin D2 in the recombinant yeast cells expressing human CYP2R1
Biochem. Biophys. Res. Commun.
434
311-315
2013
Homo sapiens (Q6VVX0), Homo sapiens
De Toni, L.; De Filippis, V.; Tescari, S.; Ferigo, M.; Ferlin, A.; Scattolini, V.; Avogaro, A.; Vettor, R.; Foresta, C.
Uncarboxylated osteocalcin stimulates 25-hydroxy vitamin D production in Leydig cell line through a GPRC6a-dependent pathway
Endocrinology
155
4266-4274
2014
Mus musculus (Q6VVW9), Mus musculus
Sundaram, K.; Sambandam, Y.; Tsuruga, E.; Wagner, C.L.; Reddy, S.V.
1alpha,25-dihydroxyvitamin D3 modulates CYP2R1 gene expression in human oral squamous cell carcinoma tumor cells
Horm. Cancer
5
90-97
2014
Homo sapiens (Q6VVX0), Homo sapiens
Zhu, J.G.; Ochalek, J.T.; Kaufmann, M.; Jones, G.; Deluca, H.F.
CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo
Proc. Natl. Acad. Sci. USA
110
15650-15655
2013
Mus musculus (Q6VVW9), Mus musculus C57BL/6 (Q6VVW9)
Ahn, J.; Yu, K.; Stolzenberg-Solomon, R.; Simon, K.C.; McCullough, M.L.; Gallicchio, L.; Jacobs, E.J.; Ascherio, A.; Helzlsouer, K.; Jacobs, K.B.; Li, Q.; Weinstein, S.J.; Purdue, M.; Virtamo, J.; Horst, R.; Wheeler, W.; Chanock, S.; Hunter, D.J.; Hayes, R.B.; Kraft, P.; Albanes, D.
Genome-wide association study of circulating vitamin D levels
Hum. Mol. Genet.
19
2739-2745
2010
Homo sapiens (Q6VVX0), Homo sapiens
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