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Disease on EC 1.14.14.24 - vitamin D 25-hydroxylase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
SNP rs12794714 of CYP2R1 is associated with serum vitamin D levels and recurrent spontaneous abortion (RSA): a case-control study.
Adenocarcinoma
Strategies and limitations associated with in vitro characterization of vitamin D receptor activators.
Vitamin D metabolic pathway genes and pancreatic cancer risk.
Adenoma
Vitamin D Receptor Genotype, Vitamin D3 Supplementation, and Risk of Colorectal Adenomas: A Randomized Clinical Trial.
Asthma
Association of T-regulatory cells and CD23/CD21 expression with vitamin D in children with asthma.
Associations Between Genetic Variants in Vitamin D Metabolism and Asthma Characteristics in Young African Americans: A Pilot Study.
Associations of Genetic Polymorphisms Relevant to Metabolic Pathway of Vitamin D3 with Development and Prognosis of Childhood Bronchial Asthma.
Asthma and genes encoding components of the vitamin D pathway.
Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.
Childhood asthma and spirometric indices are associated with polymorphic markers of two vitamin D 25-hydroxylase genes.
Autoimmune Diseases
Polymorphisms in genetics of vitamin D metabolism confer susceptibility to ocular Behçet disease in a Chinese Han population.
Single nucleotide polymorphisms in the vitamin D pathway associating with circulating concentrations of vitamin D metabolites and non-skeletal health outcomes: Review of genetic association studies.
Brain Diseases
Genetic variants underlying vitamin D metabolism and VDR-TGF?-1-SMAD3 interaction may impact on HCV progression: a study based on dbGaP data from the HALT-C study.
Brain Injuries
A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow.
Brain Ischemia
Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice.
Carcinoma
1?,25-Dihydroxyvitamin D3 Modulates CYP2R1 Gene Expression in Human Oral Squamous Cell Carcinoma Tumor Cells.
Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors.
Inhibition of cytochrome P450 2J2 by tanshinone IIA induces apoptotic cell death in hepatocellular carcinoma HepG2 cells.
Vitamin D hydroxylases CYP2R1, CYP27B1 and CYP24A1 in renal cell carcinoma.
Carcinoma, Endometrioid
Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma.
Carcinoma, Hepatocellular
CYP2J2 promotes the development of hepatocellular carcinoma by increasing the EETs production to improve HIF-1? stability.
Genetic variants underlying vitamin D metabolism and VDR-TGF?-1-SMAD3 interaction may impact on HCV progression: a study based on dbGaP data from the HALT-C study.
Inhibition of cytochrome P450 2J2 by tanshinone IIA induces apoptotic cell death in hepatocellular carcinoma HepG2 cells.
Role of cytochrome P450 2J2 on cell proliferation and resistance to an anticancer agent in hepatocellular carcinoma HepG2 cells.
Role of VDR, GC, and CYP2R1 Polymorphisms in the Development of Hepatocellular Carcinoma in Hepatitis C Virus-Infected Patients.
Carcinoma, Renal Cell
Vitamin D hydroxylases CYP2R1, CYP27B1 and CYP24A1 in renal cell carcinoma.
Cardiomegaly
Alterations in cytochrome P450-derived arachidonic acid metabolism during pressure overload-induced cardiac hypertrophy.
Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice.
Ophiopogonin D alleviates cardiac hypertrophy in rat by upregulating CYP2J3 in vitro and suppressing inflammation in vivo.
Cardiotoxicity
Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity.
Cardiovascular Diseases
Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease.
Ophiopogonin D maintains Ca(2+) homeostasis in rat cardiomyocytes in vitro by upregulating CYP2J3/EETs and suppressing ER stress.
Chlamydia Infections
Specific polymorphisms in the vitamin D metabolism pathway are not associated with susceptibility to Chlamydia trachomatis infection in humans.
Cholestasis
Hepatic vitamin D 25-hydroxylase: inhibition by bile duct ligation or bile salts.
Colitis, Ulcerative
Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis.
Colonic Neoplasms
Association of common gene variants in vitamin D modulating genes and colon cancer recurrence.
Genetic Predictors of Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer.
Colorectal Neoplasms
Association of Polymorphisms in Vitamin D-Metabolizing Enzymes DHCR7 and CYP2R1 with Cancer Susceptibility: A Systematic Review and Meta-Analysis.
Associations between common polymorphisms in CYP2R1 and GC, Vitamin D intake and risk of colorectal cancer in a prospective case-cohort study in Danes.
Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.
Dysregulation of vitamin D synthesis pathway genes in colorectal cancer: A case-control study.
Genetic Predictors of Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer.
Lack of associations between Vitamin D metabolism-related gene variants and risk of colorectal cancer.
Coronary Artery Disease
Triangular relationship between single nucleotide polymorphisms in the CYP2R1 gene (rs10741657 and rs12794714), 25-hydroxyvitamin d levels, and coronary artery disease incidence.
COVID-19
Association of Vitamin D, Zinc and Selenium Related Genetic Variants With COVID-19 Disease Severity.
Diabetes Mellitus
Cytochrome P450 2J2 polymorphism in healthy Caucasians and those with diabetes mellitus.
Diabetes Mellitus, Type 1
A rare haplotype of the vitamin D receptor gene is protective against diabetic nephropathy.
CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans.
CYP2R1-, CYP27B1- and CYP24-mRNA expression in German type 1 diabetes patients.
Inherited Variation in Vitamin D Genes Is Associated With Predisposition to Autoimmune Disease Type 1 Diabetes.
Synergism of CYP2R1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Egyptian children.
Vitamin D level and gene polymorphisms in Korean children with type 1 diabetes.
Vitamin D Pathway Genetic Variation and Type 1 Diabetes: A Case-Control Association Study.
[Vitamin D3 availability and functional activity of peripheral blood phagocytes in experimental type 1 diabetes].
Diabetes Mellitus, Type 2
Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study.
Evaluation of the Associations of GC and CYP2R1 Genes and Gene-Obesity Interactions with Type 2 Diabetes Risk in a Chinese Rural Population.
Vitamin D in Type 2 Diabetes: Genetic Susceptibility and the Response to Supplementation.
Diabetes, Gestational
Gestational diabetes mellitus and vitamin D deficiency: genetic contribution of CYP27B1 and CYP2R1 polymorphisms.
Variants in Vitamin D Binding Protein Gene Are Associated With Gestational Diabetes Mellitus.
Encephalomyelitis
Development of experimental autoimmune encephalomyelitis (EAE) in mice requires vitamin D and the vitamin D receptor.
Encephalomyelitis, Autoimmune, Experimental
Development of experimental autoimmune encephalomyelitis (EAE) in mice requires vitamin D and the vitamin D receptor.
Endometrial Neoplasms
Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma.
Endometriosis
Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers.
Endometritis
Genomic breeding values, SNP effects and gene identification for disease traits in cow training sets.
Essential Hypertension
A common polymorphism G-50T in cytochrome P450 2J2 gene is associated with increased risk of essential hypertension in a Russian population.
A comprehensive study revealed SNP-SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension risk.
Fatty Liver
Association between Subclinical Low Serum 25(OH)D in Donors and Fatty Liver Disease in Recipients after Living Donor Liver Transplantation.
Effects of Gene Variants Controlling Vitamin D Metabolism and Serum Levels on Hepatic Steatosis.
Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.
Genetic Diseases, Inborn
Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase.
Prolonged 25-OH Vitamin D Deficiency Does Not Impair Bone Mineral Density in Adult Patients With Vitamin D 25-Hydroxylase Deficiency (CYP2R1).
Graves Disease
The functional polymorphisms of VDR, GC and CYP2R1 are involved in the pathogenesis of autoimmune thyroid diseases.
Hashimoto Disease
The functional polymorphisms of VDR, GC and CYP2R1 are involved in the pathogenesis of autoimmune thyroid diseases.
Heart Failure
Endothelium-specific CYP2J2 overexpression improves cardiac dysfunction by promoting angiogenesis via Jagged1/Notch1 signaling.
Ophiopogonin D Increases SERCA2a Interaction with Phospholamban by Promoting CYP2J3 Upregulation.
Hematologic Neoplasms
Cytochrome P450 2J2, a new key enzyme in cyclophosphamide bioactivation and a potential biomarker for hematological malignancies.
Hepatitis
Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera.
Liver VDR, CYP2R1 and CYP27A1 expression: Relationship with liver histology and vitamin D3 levels in patients with NASH or HCV hepatitis.
Hepatitis B, Chronic
Genetic variation in the vitamin D pathway CYP2R1 gene predicts sustained HBeAg seroconversion in chronic hepatitis B patients treated with pegylated interferon: A multicenter study.
Hepatitis C
Impact of CYP2R1, CYP27A1 and CYP27B1 genetic polymorphisms controlling vitamin D metabolism on susceptibility to hepatitis C virus infection in a high-risk Chinese population.
Role of VDR, GC, and CYP2R1 Polymorphisms in the Development of Hepatocellular Carcinoma in Hepatitis C Virus-Infected Patients.
Hypercalcemia
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.
Hypercholesterolemia
High Fat Diet and High Cholesterol Diet Reduce Hepatic Vitamin D-25-Hydroxylase Expression and Serum 25-Hydroxyvitamin D3 Level through Elevating Circulating Cholesterol, Glucose, and Insulin Levels.
Hyperglycemia
High Fat Diet and High Cholesterol Diet Reduce Hepatic Vitamin D-25-Hydroxylase Expression and Serum 25-Hydroxyvitamin D3 Level through Elevating Circulating Cholesterol, Glucose, and Insulin Levels.
Hyperlipidemias
CYP2J2 overexpression ameliorates hyperlipidemia via increased fatty acid oxidation mediated by the AMPK pathway.
Hypertension
Associations of genetic polymorphisms of the vitamin D pathway with blood pressure in a Han Chinese population.
CYP2J2 -50 G/T and ADRB2 G46A Gene Polymorphisms in Saudi Subjects with Hypertension.
CYP2J3 Gene Delivery Reduces Insulin Resistance via Upregulation of eNOS in Fructose-treated Rats.
Increased CYP2J3 expression reduces insulin resistance in fructose-treated rats and db/db mice.
Hypertriglyceridemia
High Fat Diet and High Cholesterol Diet Reduce Hepatic Vitamin D-25-Hydroxylase Expression and Serum 25-Hydroxyvitamin D3 Level through Elevating Circulating Cholesterol, Glucose, and Insulin Levels.
Hypogonadism
Late-onset hypogonadism: beyond testosterone.
Infarction, Middle Cerebral Artery
Hyperbaric oxygenation and 20-HETE inhibition reduce stroke volume in female diabetic Sprague-Dawley rats.
Infections
Altered decidual and placental catabolism of vitamin D may contribute to the aetiology of spontaneous miscarriage.
Genetic variation in the vitamin D pathway CYP2R1 gene predicts sustained HBeAg seroconversion in chronic hepatitis B patients treated with pegylated interferon: A multicenter study.
Impact of CYP2R1, CYP27A1 and CYP27B1 genetic polymorphisms controlling vitamin D metabolism on susceptibility to hepatitis C virus infection in a high-risk Chinese population.
Vitamin D-related gene polymorphism predict treatment response to pegylated interferon-based therapy in Thai chronic hepatitis C patients.
Insulin Resistance
CYP2J3 Gene Delivery Reduces Insulin Resistance via Upregulation of eNOS in Fructose-treated Rats.
CYP2J3 Gene Delivery Up-regulated Adiponectin Expression via Reduced Endoplasmic Reticulum Stress in Adipocytes.
Increased CYP2J3 expression reduces insulin resistance in fructose-treated rats and db/db mice.
Ischemic Stroke
Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke.
Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population.
Kidney Failure, Chronic
A rare haplotype of the vitamin D receptor gene is protective against diabetic nephropathy.
Liver Cirrhosis
Association of vitamin D serum levels and its common genetic determinants, with severity of liver fibrosis in genotype 1 chronic hepatitis C patients.
Liver Diseases
Association between Subclinical Low Serum 25(OH)D in Donors and Fatty Liver Disease in Recipients after Living Donor Liver Transplantation.
Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.
Lung Neoplasms
No Association of Vitamin D Pathway Genetic Variants with Cancer Risks in a Population-Based Cohort of German Older Adults.
Mastitis
Genomic breeding values, SNP effects and gene identification for disease traits in cow training sets.
Melanoma
Antiproliferative Activity of Non-Calcemic Vitamin D Analogs on Human Melanoma Lines in Relation to VDR and PDIA3 Receptors.
Differential biological effects of 1,25-dihydroxyVitamin D3 on melanoma cell lines in vitro.
In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells.
Multiple Sclerosis
Association between age at onset of multiple sclerosis and vitamin D level-related factors.
Development of experimental autoimmune encephalomyelitis (EAE) in mice requires vitamin D and the vitamin D receptor.
Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
Myocardial Infarction
Genetic Variants of CYP2R1 Are Key Regulators of Serum Vitamin D Levels and Incidence of Myocardial Infarction in Middle-Aged Egyptians.
Neoplasms
1?,25-Dihydroxyvitamin D3 Modulates CYP2R1 Gene Expression in Human Oral Squamous Cell Carcinoma Tumor Cells.
Activation of ALDH1A1 in MDA-MB-468 breast cancer cells that over-express CYP2J2 protects against paclitaxel-dependent cell death mediated by reactive oxygen species.
Association between Vitamin D Genetic Risk Score and Cancer Risk in a Large Cohort of U.S. Women.
Association of Polymorphisms in Vitamin D-Metabolizing Enzymes DHCR7 and CYP2R1 with Cancer Susceptibility: A Systematic Review and Meta-Analysis.
CYP2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth.
CYP2J2*7 single nucleotide polymorphism in a Chinese population.
Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors.
Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma.
Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer.
Gene expression of vitamin D metabolic enzymes at baseline and in response to vitamin D treatment in thyroid cancer cell lines.
Inhibition of cytochrome P450 2J2 by tanshinone IIA induces apoptotic cell death in hepatocellular carcinoma HepG2 cells.
No Association of Vitamin D Pathway Genetic Variants with Cancer Risks in a Population-Based Cohort of German Older Adults.
Plant natural product plumbagin presents potent inhibitory effect on human cytochrome P450 2J2 enzyme.
Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers.
Neuroinflammatory Diseases
Neuroinflammation is able to downregulate cytochrome P450 epoxygenases 2J3 and 2C11 in the rat brain.
Non-alcoholic Fatty Liver Disease
Association of vitamin D levels and vitamin D-related gene polymorphisms with liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease.
Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.
Obesity
Effects of Gene Variants Controlling Vitamin D Metabolism and Serum Levels on Hepatic Steatosis.
Evaluation of the Associations of GC and CYP2R1 Genes and Gene-Obesity Interactions with Type 2 Diabetes Risk in a Chinese Rural Population.
Genetic association analysis of vitamin D pathway with obesity traits.
Obesity Decreases Hepatic 25-Hydroxylase Activity Causing Low Serum 25-Hydroxyvitamin D.
Obesity Represses CYP2R1, the Vitamin D 25-Hydroxylase, in the Liver and Extrahepatic Tissues.
Serum 25OHD3 of Obese Mice Is Affected by Liver Injury and Correlates with Testosterone Levels and Sperm Motility.
Oligospermia
Bone mineral density and testicular failure: evidence for a role of vitamin d 25-hydroxylase in human testis.
Ovarian Neoplasms
Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.
Overweight
CYP2R1 polymorphisms are important modulators of circulating 25-hydroxyvitamin D levels in elderly females with vitamin insufficiency, but not of the response to vitamin D supplementation.
Pancreatic Neoplasms
Genetic variants in vitamin d pathway genes and risk of pancreas cancer; results from a population-based case-control study in ontario, Canada.
Parkinson Disease
Genetic variants of vitamin D metabolism-related DHCR7/NADSYN1 locus and CYP2R1 gene are associated with clinical features of Parkinson's disease.
Polycystic Ovary Syndrome
Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study.
Prostatic Neoplasms
Genetic Variation in the Vitamin D Pathway in Relation to Risk of Prostate Cancer - Results from the Breast and Prostate Cancer Cohort Consortium (BPC3).
The roles of cytochrome P450 enzymes in prostate cancer development and treatment.
Vitamin D Pathway and Other Related Polymorphisms and Risk of Prostate Cancer: Results from the Prostate Cancer Prevention Trial.
Reperfusion Injury
Higher Epoxyeicosatrienoic Acids in Cardiomyocytes-Specific CYP2J2 Transgenic Mice Are Associated with Improved Myocardial Remodeling.
Rhinitis, Allergic
Association of VDR and CYP2R1 Polymorphisms with Mite-Sensitized Persistent Allergic Rhinitis in a Chinese Population.
Rickets
A genetic variant of CYP2R1 identified in a cat with type 1B vitamin D-dependent rickets: a case report.
Absence of Mutation in Coding Regions of CYP2R1 Gene in Apparent Autosomal Dominant Vitamin D 25-Hydroxylase Deficiency Rickets.
Bone mineral density and testicular failure: evidence for a role of vitamin d 25-hydroxylase in human testis.
CYP2R1 mutations causing vitamin D-deficiency rickets.
CYP2R1 Mutations Impair Generation of 25-hydroxyvitamin D and Cause an Atypical Form of Vitamin D Deficiency.
Enzymes involved in the activation and inactivation of vitamin D.
Genetic disorders of Vitamin D biosynthesis and degradation.
Genetic Expression Profile of Vitamin D Metabolizing Enzymes in the First Trimester.
Mutation of the CYP2R1 Vitamin D 25-Hydroxylase in a Saudi Arabian Family with Severe Vitamin D Deficiency.
Prolonged 25-OH Vitamin D Deficiency Does Not Impair Bone Mineral Density in Adult Patients With Vitamin D 25-Hydroxylase Deficiency (CYP2R1).
Structural analysis of CYP2R1 in complex with vitamin D3.
Two novel CYP2R1 mutations in a family with vitamin D-dependent rickets type 1b.
Vitamin D-Dependent Rickets Type 1B (25-Hydroxylase Deficiency): A Rare Condition or a Misdiagnosed Condition?
Sarcoidosis
Genes and metabolic pathway of sarcoidosis: identification of key players and risk modifiers.
Spondylitis, Ankylosing
Polymorphisms in genetics of vitamin D metabolism confer susceptibility to ocular Behçet disease in a Chinese Han population.
Squamous Cell Carcinoma of Head and Neck
1?,25-Dihydroxyvitamin D3 Modulates CYP2R1 Gene Expression in Human Oral Squamous Cell Carcinoma Tumor Cells.
Stroke
Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke.
Hypoxic preconditioning and tolerance via hypoxia inducible factor (HIF) 1alpha-linked induction of P450 2C11 epoxygenase in astrocytes.
Testicular Neoplasms
Altered bone status in unilateral testicular cancer survivors: role of CYP2R1 and its LH-dependency.
Thyroid Diseases
The functional polymorphisms of VDR, GC and CYP2R1 are involved in the pathogenesis of autoimmune thyroid diseases.
Thyroid Neoplasms
Association of Vitamin D Pathway Genetic Variation and Thyroid Cancer.
Tuberculosis
Vitamin D deficiency associates with susceptibility to tuberculosis in Pakistan, but polymorphisms in VDR, DBP and CYP2R1 do not.
Uveitis
Polymorphisms in genetics of vitamin D metabolism confer susceptibility to ocular Behçet disease in a Chinese Han population.
Uveitis, Anterior
Polymorphisms in genetics of vitamin D metabolism confer susceptibility to ocular Behçet disease in a Chinese Han population.
Virus Diseases
Impact of CYP2R1, CYP27A1 and CYP27B1 genetic polymorphisms controlling vitamin D metabolism on susceptibility to hepatitis C virus infection in a high-risk Chinese population.
Vitamin A Deficiency
Suppression of the constitutive microsomal cytochrome P450 2C11 in male rat liver during dietary vitamin A deficiency.
vitamin d 25-hydroxylase deficiency
Absence of Mutation in Coding Regions of CYP2R1 Gene in Apparent Autosomal Dominant Vitamin D 25-Hydroxylase Deficiency Rickets.
Lack of mutations in CYP2D6 and CYP27 in patients with apparent deficiency of vitamin D 25-hydroxylase.
Prolonged 25-OH Vitamin D Deficiency Does Not Impair Bone Mineral Density in Adult Patients With Vitamin D 25-Hydroxylase Deficiency (CYP2R1).
Vitamin D 25-hydroxylase deficiency.
Vitamin D Deficiency
25-Hydroxylase vitamin D deficiency in 27 Saudi Arabian subjects: a clinical and molecular report on CYP2R1 mutations.
Association of rs7041 and rs4588 Polymorphisms of the Vitamin D Binding Protein and the rs10741657 Polymorphism of CYP2R1 with Vitamin D Status Among Jordanian Patients.
Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study.
Association of vitamin D levels and vitamin D-related gene polymorphisms with liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease.
Bone mineral density and testicular failure: evidence for a role of vitamin d 25-hydroxylase in human testis.
CYP2R1 Mutations Impair Generation of 25-hydroxyvitamin D and Cause an Atypical Form of Vitamin D Deficiency.
Effects of CYP2R1 gene variants on vitamin D levels and status: A systematic review and meta-analysis.
Family-based Association between Allele T of rs4646536 in CYP27B1 and vitamin D deficiency.
Genetic influence on circulating vitamin D among Saudi Arabians.
Genetic Variants of CYP2R1 Are Key Regulators of Serum Vitamin D Levels and Incidence of Myocardial Infarction in Middle-Aged Egyptians.
Genetic Variation in CYP2R1 and GC Genes Associated With Vitamin D Deficiency Status.
Genetic Variation in Cytochrome P450 2R1 and Vitamin D Binding Protein Genes are associated with Vitamin D Deficiency in Adolescents.
Gestational diabetes mellitus and vitamin D deficiency: genetic contribution of CYP27B1 and CYP2R1 polymorphisms.
Mutation of the CYP2R1 Vitamin D 25-Hydroxylase in a Saudi Arabian Family with Severe Vitamin D Deficiency.
Obesity Represses CYP2R1, the Vitamin D 25-Hydroxylase, in the Liver and Extrahepatic Tissues.
Prolonged 25-OH Vitamin D Deficiency Does Not Impair Bone Mineral Density in Adult Patients With Vitamin D 25-Hydroxylase Deficiency (CYP2R1).
Serum 25(OH)D and vitamin D status in relation to VDR, GC and CYP2R1 variants in Chinese.
The CYP2R1 Enzyme: Structure, Function, Enzymatic Properties and Genetic Polymorphism.
Vitamin D Binding Protein Gene Polymorphism as a Risk Factor for Vitamin D Deficiency in Thais.
Vitamin D deficiency associates with susceptibility to tuberculosis in Pakistan, but polymorphisms in VDR, DBP and CYP2R1 do not.
Vitamin D Deficiency in Uygurs and Kazaks Is Associated with Polymorphisms in CYP2R1 and DHCR7/NADSYN1 Genes.
Vitamin D level and gene polymorphisms in Korean children with type 1 diabetes.
Vitamin D Status in Russian Children and Adolescents: Contribution of Genetic and Exogenous Factors.