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Reference on EC 1.14.14.14 - aromatase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bellino, F.; Holben, L.
Placental estrogen synthetase (aromatase): Evidence for phosphatase-dependent inactivation
Biochem. Biophys. Res. Commun.
162
498-504
1989
Homo sapiens
Manually annotated by BRENDA team
Kellis, J.T.; Nesnow, S.; Vickery, L.E.
Inhibition of aromatase cytochrome P-450 (estrogen synthetase) by derivatives of alpha-naphthoflavone
Biochem. Pharmacol.
35
2887-2891
1986
Homo sapiens
Manually annotated by BRENDA team
Osada, M.; Tawarayama, H.; Mori, K.
Estrogen synthesis in relation to gonadal development of Japanese scallop, Patinopecten yessoensis: Gonadal profile and immunolocalization of P450 aromatase and estrogen
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
139
123-128
2004
Mizuhopecten yessoensis
Manually annotated by BRENDA team
Monteiro, R.; Becker, H.; Azevedo, I.; Calhau, C.
Effect of hop (Humulus lupulus L.) flavonoids on aromatase (estrogen synthase) activity
J. Agric. Food Chem.
54
2938-2943
2006
Homo sapiens, Homo sapiens ATCC HTB-144
Manually annotated by BRENDA team
Thompson, E.A.Jr.; Siiteri, P.K.
The involvement of human placental microsomal cytochrome P-450 in aromatization
J. Biol. Chem.
249
5373-5378
1974
Homo sapiens
Manually annotated by BRENDA team
Fishman, J.; Goto, J.
Mechanism of estrogen biosynthesis. Participation of multiple enzyme sites in placental aromatase hydroxylations
J. Biol. Chem.
256
4466-4471
1981
Homo sapiens
Manually annotated by BRENDA team
Kellis, J.T.; Vickery, L.E.
Purification and characterization of human placental aromatase cytochrome P-450
J. Biol. Chem.
262
4413-20
1987
Homo sapiens
Manually annotated by BRENDA team
Sethumadhavan, K.; Bellino, F.
Human placental estrogen synthetase (aromatase). Effect of environment on the kinetics of protein-protein and substrate-protein interactions and the production of 19-oxygenated androgen intermediates in the purified reconstituted cytochrome P450 enzyme system
J. Steroid Biochem. Mol. Biol.
39
381-394
1991
Homo sapiens
Manually annotated by BRENDA team
Ghosh, D.; Griswold, J.; Erman, M.; Pangborn, W.
Structural basis for androgen specificity and oestrogen synthesis in human aromatase
Nature
457
219-223
2009
Homo sapiens (P11511), Homo sapiens
Manually annotated by BRENDA team
Yague, J.G.; Lavaque, E.; Carretero, J.; Azcoitia, I.; Garcia-Segura, L.M.
Aromatase, the enzyme responsible for estrogen biosynthesis, is expressed by human and rat glioblastomas
Neurosci. Lett.
368
279-284
2004
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Ohlsson, C.; Hammarstedt, A.; Vandenput, L.; Saarinen, N.; Ryberg, H.; Windahl, S.H.; Farman, H.H.; Jansson, J.O.; Moverare-Skrtic, S.; Smith, U.; Zhang, F.P.; Poutanen, M.; Hedjazifar, S.; Sjoegren, K.
Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male mice
Am. J. Physiol. Endocrinol. Metab.
313
E450-E462
2017
Mus musculus (P28649), Mus musculus
Manually annotated by BRENDA team
Zuloaga, K.L.; Davis, C.M.; Zhang, W.; Alkayed, N.J.
Role of aromatase in sex-specific cerebrovascular endothelial function in mice
Am. J. Physiol. Heart Circ. Physiol.
306
H929-H937
2014
Mus musculus (P28649)
Manually annotated by BRENDA team
Mills, L.J.; Gutjahr-Gobell, R.E.; Zaroogian, G.E.; Horowitz, D.B.; Laws, S.C.
Modulation of aromatase activity as a mode of action for endocrine disrupting chemicals in a marine fish
Aquat. Toxicol.
147
140-150
2014
Tautogolabrus adspersus
Manually annotated by BRENDA team
Di Matteo, M.; Ammazzalorso, A.; Andreoli, F.; Caffa, I.; De Filippis, B.; Fantacuzzi, M.; Giampietro, L.; Maccallini, C.; Nencioni, A.; Parenti, M.D.; Soncini, D.; Del Rio, A.; Amoroso, R.
Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors
Bioorg. Med. Chem. Lett.
26
3192-3194
2016
Homo sapiens
Manually annotated by BRENDA team
Prior, A.M.; Yu, X.; Park, E.J.; Kondratyuk, T.P.; Lin, Y.; Pezzuto, J.M.; Sun, D.
Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1
Bioorg. Med. Chem. Lett.
27
5393-5399
2017
Homo sapiens (P11511)
Manually annotated by BRENDA team
Sun, C.; Liu, Y.; Liu, Y.; Zhao, M.; Zhai, J.; Hao, P.; Wang, Y.; Ji, Y.
Characterization of aromatase expression in the spinal cord of an animal model of familial ALS
Brain Res. Bull.
132
180-189
2017
Mus musculus (P28649), Mus musculus
Manually annotated by BRENDA team
Caruso, C.C.; Breton, T.S.; Berlinsky, D.L.
The effects of temperature on ovarian aromatase (cyp19a1a) expression and sex differentiation in summer flounder (Paralichthys dentatus)
Fish Physiol. Biochem.
42
795-805
2016
Paralichthys dentatus (A0A0H4KB14), Paralichthys dentatus
Manually annotated by BRENDA team
Parsley, L.M.; Wapstra, E.; Jones, S.M.
Placental and embryonic tissues exhibit aromatase activity in the viviparous lizard Niveoscincus metallicus
Gen. Comp. Endocrinol.
200
61-66
2014
Carinascincus metallicus
Manually annotated by BRENDA team
Chaube, R.; Rawat, A.; Joy, K.P.
Molecular cloning and characterization of brain and ovarian cytochrome P450 aromatase genes in the catfish Heteropneustes fossilis Sex, tissue and seasonal variation in, and effects of gonadotropin on gene expression
Gen. Comp. Endocrinol.
221
120-133
2015
Heteropneustes fossilis (A0A068CIW9), Heteropneustes fossilis (A0A068CLX6), Heteropneustes fossilis
Manually annotated by BRENDA team
Ramallo, M.R.; Morandini, L.; Birba, A.; Somoza, G.M.; Pandolfi, M.
From molecule to behavior Brain aromatase (cyp19a1b) characterization, expression analysis and its relation with social status and male agonistic behavior in a Neotropical cichlid fish
Horm. Behav.
89
176-188
2017
Cichlasoma dimerus (M1GNQ2), Cichlasoma dimerus
Manually annotated by BRENDA team
Aggarwal, N.; Goswami, S.V.; Khandelwal, P.; Sehgal, N.
Aromatase activity in brain and ovary seasonal variations correlated with circannual gonadal cycle in the catfish, Heteropneustes fossilis
Indian J. Exp. Biol.
52
527-537
2014
Heteropneustes fossilis
Manually annotated by BRENDA team
Di Nardo, G.; Breitner, M.; Bandino, A.; Ghosh, D.; Jennings, G.K.; Hackett, J.C.; Gilardi, G.
Evidence for an elevated aspartate pK(a) in the active site of human aromatase
J. Biol. Chem.
290
1186-1196
2015
Homo sapiens (P11511), Homo sapiens
Manually annotated by BRENDA team
Aversa, A.; Fittipaldi, S.; Bimonte, V.M.; Wannenes, F.; Papa, V.; Francomano, D.; Greco, E.A.; Lenzi, A.; Migliaccio, S.
Tadalafil modulates aromatase activity and androgen receptor expression in a human osteoblastic cell in vitro model
J. Endocrinol. Invest.
39
199-205
2016
Homo sapiens (P11511), Homo sapiens
Manually annotated by BRENDA team
Magistrato, A.; Sgrignani, J.; Krause, R.; Cavalli, A.
Single or multiple access channels to the CYP450s active site? An answer from free energy simulations of the human aromatase enzyme
J. Phys. Chem. Lett.
8
2036-2042
2017
Homo sapiens (P11511), Homo sapiens
Manually annotated by BRENDA team
Martin, L.L.; Holien, J.K.; Mizrachi, D.; Corbin, C.J.; Conley, A.J.; Parker, M.W.; Rodgers, R.J.
Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and efficiency
J. Steroid Biochem. Mol. Biol.
154
294-301
2015
Homo sapiens (P11511), Sus scrofa (P79304)
Manually annotated by BRENDA team
Baravalle, R.; Valetti, F.; Catucci, G.; Gambarotta, G.; Chiesa, M.; Maurelli, S.; Giamello, E.; Barone, I.; Catalano, S.; Ando, S.; Di Nardo, G.; Gilardi, G.
Effect of sildenafil on human aromatase activity From in vitro structural analysis to catalysis and inhibition in cells
J. Steroid Biochem. Mol. Biol.
165
438-447
2017
Homo sapiens (P11511), Homo sapiens
Manually annotated by BRENDA team
Bouchoucha, N.; Samara-Boustani, D.; Pandey, A.V.; Bony-Trifunovic, H.; Hofer, G.; Aigrain, Y.; Polak, M.; Flueck, C.E.
Characterization of a novel CYP19A1 (aromatase) R192H mutation causing virilization of a 46,XX newborn, undervirilization of the 46,XY brother, but no virilization of the mother during pregnancies
Mol. Cell. Endocrinol.
390
8-17
2014
Homo sapiens (P11511), Homo sapiens
Manually annotated by BRENDA team
Hudon Thibeault, A.A.; Vaillancourt, C.; Sanderson, J.T.
Profile of CYP19A1 mRNA expression and aromatase activity during syncytialization of primary human villous trophoblast cells at term
Biochimie
148
12-17
2018
Homo sapiens (P11511), Homo sapiens
Manually annotated by BRENDA team
Di Nardo, G.; Di Venere, A.; Zhang, C.; Nicolai, E.; Castrignano, S.; Di Paola, L.; Gilardi, G.; Mei, G.
Polymorphism on human aromatase affects protein dynamics and substrate binding spectroscopic evidence
Biol. Direct
16
008
2021
Homo sapiens (P11511), Homo sapiens
Manually annotated by BRENDA team
Giampietro, L.; Gallorini, M.; Gambacorta, N.; Ammazzalorso, A.; De Filippis, B.; Della Valle, A.; Fantacuzzi, M.; Maccallini, C.; Mollica, A.; Cataldi, A.; Nicolotti, O.; Amoroso, R.
Synthesis, structure-activity relationships and molecular docking studies of phenyldiazenyl sulfonamides as aromatase inhibitors
Eur. J. Med. Chem.
224
113737
2021
Homo sapiens (P11511), Homo sapiens
Manually annotated by BRENDA team
Tuzuner, M.B.; Ozturk, T.; Ilvan, S.; Turna, H.; Yurdun, T.; Yilmaz-Aydogan, H.; Ozturk, O.
Local aromatase activity alterations in breast cancer tissues A potential way of decision support for clinicians
Exp. Mol. Pathol.
118
104574
2021
Homo sapiens (P11511), Homo sapiens
Manually annotated by BRENDA team
Rahman, M.; Thomas, P.
Molecular characterization and expression of cytochrome P450 aromatase in Atlantic croaker brain regulation by antioxidant status and nitric oxide synthase during hypoxia stress
Front. Physiol.
12
720200
2021
Micropogonias undulatus (Q3LS70), Micropogonias undulatus
Manually annotated by BRENDA team
Guan, Y.; Lu, Y.; Wang, Y.; Xue, K.
Let-7g inhibits synthesis of estradiol by downregulating activity of aromatase in JEG3 cells
J. Cell. Biochem.
120
1819-1826
2019
Homo sapiens (P11511), Homo sapiens
Manually annotated by BRENDA team
Zarate-Perez, F.; Velazquez-Fernandez, J.B.; Jennings, G.K.; Shock, L.S.; Lyons, C.E.; Hackett, J.C.
Biophysical characterization of Aptenodytes forsteri cytochrome P450 aromatase
J. Inorg. Biochem.
184
79-87
2018
Aptenodytes forsteri (A0A087RFY9), Aptenodytes forsteri
Manually annotated by BRENDA team
Roleira, F.M.F.; Varela, C.; Amaral, C.; Costa, S.C.; Correia-da-Silva, G.; Moraca, F.; Costa, G.; Alcaro, S.; Teixeira, N.A.A.; Tavares da Silva, E.J.
C-6alpha- vs C-7alpha-substituted steroidal aromatase inhibitors which is better? synthesis, biochemical evaluation, docking studies, and structure-activity relationships
J. Med. Chem.
62
3636-3657
2019
Homo sapiens (P11511)
Manually annotated by BRENDA team
Parween, S.; DiNardo, G.; Baj, F.; Zhang, C.; Gilardi, G.; Pandey, A.V.
Differential effects of variations in human P450 oxidoreductase on the aromatase activity of CYP19A1 polymorphisms R264C and R264H
J. Steroid Biochem. Mol. Biol.
196
105507
2020
Homo sapiens (P11511), Homo sapiens
Manually annotated by BRENDA team
Williams, G.P.; Darbre, P.D.
Low-dose environmental endocrine disruptors, increase aromatase activity, estradiol biosynthesis and cell proliferation in human breast cells
Mol. Cell. Endocrinol.
486
55-64
2019
Homo sapiens (P11511), Homo sapiens
Manually annotated by BRENDA team
Acar Cevik, U.; Kaya Cavusoglu, B.; Saglik, B.N.; Osmaniye, D.; Levent, S.; Ilgin, S.; Oezkay, Y.; Kaplancikli, Z.A.
Synthesis, docking studies and biological activity of new benzimidazole-triazolothiadiazine derivatives as aromatase inhibitor
Molecules
25
1642
2020
Homo sapiens (P11511), Homo sapiens
Manually annotated by BRENDA team
Chayawan, C.; Toma, C.; Benfenati, E.; Caballero Alfonso, A.
Towards an understanding of the mode of action of human aromatase activity for azoles through quantum chemical descriptors-based regression and structure activity relationship modeling analysis
Molecules
25
739
2020
Homo sapiens (P11511), Homo sapiens
Manually annotated by BRENDA team
Siddiqui, M.; Atia-tul-Waha, A.; Naveed Shaikh, N.; Baydoun, E.; Atta-ur-Rahma, A.; Choudhary, M.
Biocatalytic transformation of steroidal drugs oxandrolone and ganaxolone, and aromatase inhibitory activity of transformed products
Phytochem. Lett.
44
137-141
2021
Homo sapiens (P11511)
-
Manually annotated by BRENDA team
Caballero Alfonso, A.Y.; Mora Lagares, L.; Novic, M.; Benfenati, E.; Kumar, A.; Chayawan, A.
Exploration of structural requirements for azole chemicals towards human aromatase CYP19A1 activity Classification modeling, structure-activity relationships and read-across study
Toxicol. In Vitro
81
105332
2022
Homo sapiens (P11511)
Manually annotated by BRENDA team
Doering, J.A.; Villeneuve, D.L.; Fay, K.A.; Randolph, E.C.; Jensen, K.M.; Kahl, M.D.; LaLone, C.A.; Ankley, G.T.
Differential sensitivity to in vitro inhibition of cytochrome P450 aromatase (CYP19) activity among 18 freshwater fishes
Toxicol. Sci.
170
394-403
2019
Esox lucius, Oncorhynchus mykiss, Pimephales promelas, Catostomus commersonii, Polyodon spathula
Manually annotated by BRENDA team