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Information on EC 1.14.14.1 - unspecific monooxygenase
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EC Tree
1.14.14.1 unspecific monooxygenaseIUBMB Comments
A group of P-450 heme-thiolate proteins, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups. Together with EC 1.6.2.4, NADPH---hemoprotein reductase, it forms a system in which two reducing equivalents are supplied by NADPH. Some of the reactions attributed to EC 1.14.15.3, alkane 1-monooxygenase, belong here.
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Word Map
- 1.14.14.1
- cyp3a4
- hepatocytes
- cyp2c19
-
drug-drug
- epoxide
- phenobarbital
-
dosing
- women
-
smoke
- heme
- s-transferase
- isozymes
- cholesterol
-
hepatotoxicity
-
smoking
-
polycyclic
- adduct
-
benzoapyrene
- urine
-
pharmacogenetic
-
steroidogenic
-
disposition
- androgen
-
interindividual
-
pharmacodynamic
- gst
- warfarin
-
toxicological
-
concentration-time
- progesterone
- p-glycoprotein
-
caucasian
- estradiol
-
genotoxic
-
ethnic
-
antidepressant
- steroidogenesis
-
insecticide
-
cigarette
- caffeine
-
glucuronidation
-
coadministration
- androstenedione
-
anticoagulant
-
trough
- coumarins
- acetaminophen
- biphenyls
- tacrolimus
- erythromycin
- synthesis
- biotechnology
- medicine
- environmental protection
- agriculture
The enzyme appears in viruses and cellular organisms
Synonyms
p450, cyp2d6, cyp1a1, cyp2e1, cyp1a2, cyp2c9, cyp1b1, cyp3a5, cyp2b6, cyp1a, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3AH15
-
-
-
-
6 beta-hydroxylase
-
-
-
-
6-beta-testosterone hydroxylase
-
-
-
-
Aldehyde oxygenase
-
-
-
-
Arachidonic acid epoxygenase
-
-
-
-
aromatase
-
-
-
-
aryl hydrocarbon hydroxylase
-
-
-
-
aryl-4-monooxygenase
-
-
-
-
Brain aromatase
-
-
-
-
Clone PF26
-
-
-
-
Clone PF3/46
-
-
-
-
Coumarin 7-hydroxylase
-
-
-
-
CYP1A1
-
-
-
-
CYP1A2
-
-
-
-
CYP1A3
-
-
-
-
CYP2A3
-
-
-
-
CYP4502F4
-
-
-
-
CYP6B1V1/CYP6B1V2/ CYP6B1V3
-
-
-
-
CYP6B3V1/CYP6B3V2
-
-
-
-
CYP6B4V1/CYP6B4V2
-
-
-
-
CYP6B5V1
-
-
-
-
CYPIA1
-
-
-
-
CYPIA2
-
-
-
-
CYPIA4
-
-
-
-
CYPIA5
-
-
-
-
CYPIB1
-
-
-
-
CYPIIA1
-
-
-
-
CYPIIA10
-
-
-
-
CYPIIA11
-
-
-
-
CYPIIA12
-
-
-
-
CYPIIA13
-
-
-
-
CYPIIA2
-
-
-
-
CYPIIA3
-
-
-
-
CYPIIA4
-
-
-
-
CYPIIA5
-
-
-
-
CYPIIA6
-
-
-
-
CYPIIA7
-
-
-
-
CYPIIA8
-
-
-
-
CYPIIA9
-
-
-
-
CYPIIB1
-
-
-
-
CYPIIB10
-
-
-
-
CYPIIB11
-
-
-
-
CYPIIB12
-
-
-
-
CYPIIB19
-
-
-
-
CYPIIB2
-
-
-
-
CYPIIB20
-
-
-
-
CYPIIB3
-
-
-
-
CYPIIB4
-
-
-
-
CYPIIB5
-
-
-
-
CYPIIB6
-
-
-
-
CYPIIB9
-
-
-
-
CYPIIC1
-
-
-
-
CYPIIC10
-
-
-
-
CYPIIC11
-
-
-
-
CYPIIC12
-
-
-
-
CYPIIC13
-
-
-
-
CYPIIC14
-
-
-
-
CYPIIC15
-
-
-
-
CYPIIC16
-
-
-
-
CYPIIC17
-
-
-
-
CYPIIC18
-
-
-
-
CYPIIC19
-
-
-
-
CYPIIC2
-
-
-
-
CYPIIC20
-
-
-
-
CYPIIC21
-
-
-
-
CYPIIC22
-
-
-
-
CYPIIC23
-
-
-
-
CYPIIC24
-
-
-
-
CYPIIC25
-
-
-
-
CYPIIC26
-
-
-
-
CYPIIC27
-
-
-
-
CYPIIC28
-
-
-
-
CYPIIC29
-
-
-
-
CYPIIC3
-
-
-
-
CYPIIC30
-
-
-
-
CYPIIC31
-
-
-
-
CYPIIC37
-
-
-
-
CYPIIC38
-
-
-
-
CYPIIC39
-
-
-
-
CYPIIC4
-
-
-
-
CYPIIC40
-
-
-
-
CYPIIC41
-
-
-
-
CYPIIC42
-
-
-
-
CYPIIC5
-
-
-
-
CYPIIC6
-
-
-
-
CYPIIC7
-
-
-
-
CYPIIC8
-
-
-
-
CYPIIC9
-
-
-
-
CYPIID1
-
-
-
-
CYPIID10
-
-
-
-
CYPIID11
-
-
-
-
CYPIID14
-
-
-
-
CYPIID15
-
-
-
-
CYPIID16
-
-
-
-
CYPIID17
-
-
-
-
CYPIID18
-
-
-
-
CYPIID19
-
-
-
-
CYPIID2
-
-
-
-
CYPIID3
-
-
-
-
CYPIID4
-
-
-
-
CYPIID5
-
-
-
-
CYPIID6
-
-
-
-
CYPIID9
-
-
-
-
CYPIIE1
-
-
-
-
CYPIIF1
-
-
-
-
CYPIIF3
-
-
-
-
CYPIIF4
-
-
-
-
CYPIIG1
-
-
-
-
CYPIIH1
-
-
-
-
CYPIIH2
-
-
-
-
CYPIIIA1
-
-
-
-
CYPIIIA10
-
-
-
-
CYPIIIA11
-
-
-
-
CYPIIIA12
-
-
-
-
CYPIIIA13
-
-
-
-
CYPIIIA14
-
-
-
-
CYPIIIA15
-
-
-
-
CYPIIIA16
-
-
-
-
CYPIIIA17
-
-
-
-
CYPIIIA18
-
-
-
-
CYPIIIA19
-
-
-
-
CYPIIIA2
-
-
-
-
CYPIIIA21
-
-
-
-
CYPIIIA24
-
-
-
-
CYPIIIA25
-
-
-
-
CYPIIIA27
-
-
-
-
CYPIIIA28
-
-
-
-
CYPIIIA29
-
-
-
-
CYPIIIA3
-
-
-
-
CYPIIIA30
-
-
-
-
CYPIIIA31
-
-
-
-
CYPIIIA5
-
-
-
-
CYPIIIA6
-
-
-
-
CYPIIIA7
-
-
-
-
CYPIIIA8
-
-
-
-
CYPIIIA9
-
-
-
-
CYPIIJ1
-
-
-
-
CYPIIJ2
-
-
-
-
CYPIIJ3
-
-
-
-
CYPIIJ5
-
-
-
-
CYPIIJ6
-
-
-
-
CYPIIK1
-
-
-
-
CYPIIK3
-
-
-
-
CYPIIK4
-
-
-
-
CYPIIL1
-
-
-
-
CYPIIM1
-
-
-
-
CYPIVA4
-
-
-
-
CYPIVA8
-
-
-
-
CYPIVB1
-
-
-
-
CYPIVC1
-
-
-
-
CYPIVF1
-
-
-
-
CYPIVF11
-
-
-
-
CYPIVF12
-
-
-
-
CYPIVF4
-
-
-
-
CYPIVF5
-
-
-
-
CYPIVF6
-
-
-
-
CYPIVF8
-
-
-
-
CYPVIA1
-
-
-
-
CYPVIB1
-
-
-
-
CYPVIB2
-
-
-
-
CYPVIB4
-
-
-
-
CYPVIB5
-
-
-
-
CYPVIB6
-
-
-
-
CYPVIB7
-
-
-
-
CYPXIX
-
-
-
-
CYPXIXA1
-
-
-
-
CYPXIXA2
-
-
-
-
CYPXIXA3
-
-
-
-
Cytochrome P450-D2
-
-
-
-
DAH1
-
-
-
-
DAH2
-
-
-
-
Debrisoquine 4-hydroxylase
-
-
-
-
Estrogen synthetase
-
-
-
-
flavoprotein monooxygenase
-
-
-
-
flavoprotein-linked monooxygenase
-
-
-
-
Hepatic cytochrome P-450MC1
-
-
-
-
HLp
-
-
-
-
IIA3
-
-
-
-
Isozyme 3A
-
-
-
-
Laurate omega-1 hydroxylase
-
-
-
-
Lauric acid omega-6-hydroxylase
-
-
-
-
LMC1
-
-
-
-
Mephenytoin 4-hydroxylase
-
-
-
-
microsomal monooxygenase
-
-
-
-
microsomal P-450
-
-
-
-
OLF2
-
-
-
-
Olfactive
-
-
-
-
Ovarian aromatase
-
-
-
-
oxygenase, flavoprotein-linked mono-
-
-
-
-
P(3)450
-
-
-
-
P-448
-
-
-
-
P-450 PHPAH1
-
-
-
-
P-450(M-1)
-
-
-
-
P-450-MK2
-
-
-
-
P-450AROM
-
-
-
-
P-450IB
-
-
-
-
P-450IIIAM1
-
-
-
-
P-450MC
-
-
-
-
P-450MP
-
-
-
-
P-450UT
-
-
-
-
P1-88
-
-
-
-
P24
-
-
-
-
P450 17-alpha
-
-
-
-
P450 2D-29/2D-35
-
-
-
-
P450 CM3A-10
-
-
-
-
P450 DUT2
-
-
-
-
P450 FA
-
-
-
-
P450 FI
-
-
-
-
P450 form 3B
-
-
-
-
P450 form HP1
-
-
-
-
P450 HSM1
-
-
-
-
P450 HSM2
-
-
-
-
P450 HSM3
-
-
-
-
P450 HSM4
-
-
-
-
P450 IIB1
-
-
-
-
P450 IIC2
-
-
-
-
P450 LM4
-
-
-
-
P450 LM6
-
-
-
-
P450 LMC2
-
-
-
-
P450 MD
-
-
-
-
P450 MP-12/MP-20
-
-
-
-
P450 P49
-
-
-
-
P450 PB1
-
-
-
-
P450 PB4
-
-
-
-
P450 PBC1
-
-
-
-
P450 PBC2
-
-
-
-
P450 PBC3
-
-
-
-
P450 PBC4
-
-
-
-
P450 PCHP3
-
-
-
-
P450 PCHP7
-
-
-
-
P450 TCDDAA
-
-
-
-
P450 TCDDAHH
-
-
-
-
P450 type B2
-
-
-
-
P450 types B0 and B1
-
-
-
-
P450(I)
-
-
-
-
P450-11A
-
-
-
-
P450-15-alpha
-
-
-
-
P450-15-COH
-
-
-
-
P450-16-alpha
-
-
-
-
P450-254C
-
-
-
-
P450-3C
-
-
-
-
P450-6B/29C
-
-
-
-
P450-A3
-
-
-
-
P450-AFB
-
-
-
-
P450-ALC
-
-
-
-
P450-CMF1A
-
-
-
-
P450-CMF1B
-
-
-
-
P450-CMF2
-
-
-
-
P450-CMF3
-
-
-
-
P450-DB1
-
-
-
-
P450-DB2
-
-
-
-
P450-DB3
-
-
-
-
P450-DB4
-
-
-
-
P450-DB5
-
-
-
-
P450-HFLA
-
-
-
-
P450-HP
-
-
-
-
P450-IIA10
-
-
-
-
P450-IIA11
-
-
-
-
P450-IIA3.1
-
-
-
-
P450-IIA3.2
-
-
-
-
P450-IIA4
-
-
-
-
P450-KP1
-
-
-
-
P450-LM2
-
-
-
-
P450-MC1
-
-
-
-
P450-MC4
-
-
-
-
P450-MK1
-
-
-
-
P450-MKJ1
-
-
-
-
P450-MKMP13
-
-
-
-
P450-MKNF2
-
-
-
-
P450-NMB
-
-
-
-
P450-OLF1
-
-
-
-
P450-OLF3
-
-
-
-
P450-P1
-
-
-
-
P450-P2/P450-P3
-
-
-
-
P450-P3
-
-
-
-
P450-PB1 and P450-PB2
-
-
-
-
P450-PCN1
-
-
-
-
P450-PCN2
-
-
-
-
P450-PCN3
-
-
-
-
P450-PM4
-
-
-
-
P450-PP1
-
-
-
-
P450-PROS2
-
-
-
-
P4501A1
-
-
-
-
P450CB
-
-
-
-
P450CMEF
-
-
-
-
P450E
-
-
-
-
P450EF
-
-
-
-
P450F
-
-
-
-
P450H
-
-
-
-
P450I
-
-
-
-
P450IIC5
-
-
-
-
P450MT2
-
-
-
-
P450RAP
-
-
-
-
P450RLM6
-
-
-
-
P52
-
-
-
-
PB15
-
-
-
-
PHP2
-
-
-
-
PHP3
-
-
-
-
Progesterone 21-hydroxylase
-
-
-
-
Prostaglandin omega-hydroxylase
-
-
-
-
PTF1
-
-
-
-
PTF2
-
-
-
-
S-mephenytoin 4-hydroxylase
-
-
-
-
Steroid hormones 7-alpha-hydroxylase
-
-
-
-
Testosterone 15-alpha-hydroxylase
-
-
-
-
Testosterone 16-alpha hydroxylase
-
-
-
-
Testosterone 6-beta-hydroxylase
-
-
-
-
Testosterone 7-alpha-hydroxylase
-
-
-
-
xenobiotic monooxygenase
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Deamination
-
-
-
-
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
sulfoxidation
-
-
-
-
hydroxylation
-
-
-
-
epoxidation
-
-
-
-
N-oxidation
-
-
-
-
O-dealkylation
-
-
-
-
desulfation
-
-
-
-
reduction of azo, nitro, N-oxide groups
-
-
-
-
N-dealkylation
-
-
-
-
S-dealkylation
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
Aminobenzoate degradation, Arachidonic acid metabolism, Biosynthesis of secondary metabolites, Caffeine metabolism, Drug metabolism - cytochrome P450, Fatty acid degradation, Linoleic acid metabolism, Metabolism of xenobiotics by cytochrome P450, Microbial metabolism in diverse environments, Retinol metabolism, Steroid hormone biosynthesis, Tryptophan metabolism
-
-, -, -, -, -, -, -, -, -
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SYSTEMATIC NAME
IUBMB Comments
substrate,NADPH-hemoprotein reductase:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
A group of P-450 heme-thiolate proteins, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups. Together with EC 1.6.2.4, NADPH---hemoprotein reductase, it forms a system in which two reducing equivalents are supplied by NADPH. Some of the reactions attributed to EC 1.14.15.3, alkane 1-monooxygenase, belong here.
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CAS REGISTRY NUMBER
COMMENTARY
62213-32-5
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
17alpha-hydroxyprogesterone deacetylase deficiency
A 5'-splice site mutation in the cytochrome P450 steroid 17alpha-hydroxylase gene in 17alpha-hydroxylase deficiency.
17alpha-hydroxyprogesterone deacetylase deficiency
A Missense Mutation in the Human Cytochrome b5 Gene causes 46,XY Disorder of Sex Development due to True Isolated 17,20 Lyase Deficiency.
Aberrant Crypt Foci
CYP27A1 and CYP24 expression as a function of malignant transformation in the colon.
Aberrant Crypt Foci
Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol.
Aberrant Crypt Foci
Role of Hepatic and Intestinal P450 Enzymes in the Metabolic Activation of the Colon Carcinogen Azoxymethane in Mice.
Aberrant Crypt Foci
[Effects of astragalosides on induction of colorectal aberrant crypt foci by dimethylhydrazine and metabolizing enzymes in liver microsomes in rats]
Abortion, Habitual
Role of CYP17 and CYP19 polymorphisms in idiopathic recurrent miscarriages among South Indian women.
Abortion, Spontaneous
Ah receptor, CYP1A1, CYP1A2 and CYP1B1 gene polymorphisms are not involved in the risk of recurrent pregnancy loss.
Abortion, Spontaneous
Altered decidual and placental catabolism of vitamin D may contribute to the aetiology of spontaneous miscarriage.
Abortion, Spontaneous
Association between LRH-1 single nucleotide polymorphisms and unexplained recurrent spontaneous abortion in Chinese Han couples.
Abortion, Spontaneous
Association of cytochrome P450 1B1 polymorphism with first-trimester miscarriage.
Abortion, Spontaneous
Caffeine metabolism and the risk of spontaneous abortion of normal karyotype fetuses.
Acidosis
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
Acidosis, Lactic
[Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs].
Acidosis, Renal Tubular
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
Acne Vulgaris
3,4,3',4'-Tetrachloro azoxybenzene and azobenzene: potent inducers of aryl hydrocarbon hydroxylase.
Acne Vulgaris
Aryl Hydrocarbon Receptor Activation in Acne Vulgaris Skin: A Case Series from the Region of Naples, Italy.
Acne Vulgaris
Association of the CYP17 MSP AI (T-34C) and CYP19 codon 39 (Trp/Arg) polymorphisms with susceptibility to acne vulgaris.
Acne Vulgaris
Gefitinib: new preparation. Non small-cell lung cancer: stricter assessment needed.
Acne Vulgaris
Gene variants associated with acne vulgaris presentation and severity: a systematic review and meta-analysis.
Acne Vulgaris
Mild cutaneous manifestation in two young women with extraordinary hyperandrogenemia.
Acne Vulgaris
Polymorphisms in the cytochrome P-450 (CYP) 1A1 and 17 genes are not associated with acne vulgaris in the Polish population.
Acne Vulgaris
Talarozole, a selective inhibitor of P450-mediated all-trans retinoic acid for the treatment of psoriasis and acne.
Acquired Immunodeficiency Syndrome
Altered pharmacokinetics and pharmacodynamics of repaglinide by ritonavir in rats with healthy, diabetic and impaired hepatic function.
Acquired Immunodeficiency Syndrome
Cost-effectiveness of CYP2B6 genotyping to optimize efavirenz dosing in HIV clinical practice.
Acquired Immunodeficiency Syndrome
Discordant Associations Between SLCO1B1 521T?C and Plasma Levels of Ritonavir-boosted Protease Inhibitors in AIDS Clinical Trials Group Study A5146.
Acquired Immunodeficiency Syndrome
Distribution of Polymorphisms in Cytochrome P450 2B6, Histocompatibility Complex P5, Chemokine Coreceptor 5, and Interleukin 28B Genes in Inhabitants from the Central Area of Argentina.
Acquired Immunodeficiency Syndrome
Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study.
Acquired Immunodeficiency Syndrome
Enzyme-substrate complementarity governs access to a cationic reaction manifold in the P450(BM3)-catalysed oxidation of cyclopropyl fatty acids.
Acquired Immunodeficiency Syndrome
Evidence for intraspecific endocrine disruption of Geukensia demissa (Atlantic ribbed mussel) in an urban watershed.
Acquired Immunodeficiency Syndrome
Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants.
Acquired Immunodeficiency Syndrome
Genotype and phenotype of cytochrome P450 2D6 in human immunodeficiency virus-positive patients and patients with acquired immunodeficiency syndrome.
Acquired Immunodeficiency Syndrome
Hydrogen-Bonded Dioxygen Adduct of an Iron Porphyrin with an Alkanethiolate Ligand: An Elaborate Model of Cytochrome P450 This research was supported by the Ministry of Education, Science, and Culture, Japan (Grant-in Aids #08CE2005, 09235225, and 11228207 to Y.N.) and through an Encouragement of Young Scientists stipendium (#08740500 to F.T.).
Acquired Immunodeficiency Syndrome
Long-enduring primary hepatocyte-based co-cultures improve prediction of hepatotoxicity.
Acquired Immunodeficiency Syndrome
NADPH-Cytochrome P450 Reductase Mediates the Resistance of Aphis (Toxoptera) citricidus (Kirkaldy) to Abamectin.
Acquired Immunodeficiency Syndrome
Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 2: Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system.
Acquired Immunodeficiency Syndrome
Structure-activity relationship and in vitro inhibition of human cytochrome CYP2A6 and CYP2A13 by flavonoids.
Acute Coronary Syndrome
Association between cytochrome P450 2C19 polymorphism and clinical outcomes in clopidogrel-treated Uygur population with acute coronary syndrome: a retrospective study.
Acute Coronary Syndrome
Clopidogrel versus Ticagrelor in CYP2C19 Loss-of-Function Allele Noncarriers: A Real-World Study in China.
Acute Coronary Syndrome
Contribution of CYP27B1 and CYP24A1 Genetic Variations to the Incidence of Acute Coronary Syndrome and to Vitamin D Serum Level.
Acute Coronary Syndrome
Correlation of CYP2D6 allelic polymorphism to outcome of acute coronary syndrome in mid-Euphrates Iraqi patients on metoprolol therapy.
Acute Coronary Syndrome
Cost-effectiveness of cytochrome P450 2C19 *2 genotype-guided selection of clopidogrel or ticagrelor in Chinese patients with acute coronary syndrome.
Acute Coronary Syndrome
Cost-Effectiveness of Multigene Pharmacogenetic Testing in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention.
Acute Coronary Syndrome
CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndromes patients.
Acute Coronary Syndrome
CYP2C19*17 May Increase the Risk of Death Among Patients with an Acute Coronary Syndrome and Non-Valvular Atrial Fibrillation Who Receive Clopidogrel and Rivaroxaban.
Acute Coronary Syndrome
Cytochrome P450 CYP 2C19*2 Associated with Adverse 1-Year Cardiovascular Events in Patients with Acute Coronary Syndrome.
Acute Coronary Syndrome
Economic Evaluations of CYP2C19 Genotype-Guided Antiplatelet Therapy Compared to the Universal Use of Antiplatelets in Patients With Acute Coronary Syndrome: A Systematic Review.
Acute Coronary Syndrome
Effect of cytochrome P450 2C19 polymorphism on adverse cardiovascular events after drug-eluting stent implantation in a large Hakka population with acute coronary syndrome receiving clopidogrel in southern China.
Acute Coronary Syndrome
Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome.
Acute Coronary Syndrome
Effects of CYP2C19 allelic variants on inhibition of platelet aggregation and major adverse cardiovascular events in Japanese patients with acute coronary syndrome: The PRASFIT-ACS study.
Acute Coronary Syndrome
Frequency of CYP3A4, CYP3A5, CYP2C9, and CYP2C19 variant alleles in patients receiving clopidogrel that experience repeat acute coronary syndrome.
Acute Coronary Syndrome
Impact of CYP2C9 and VKORC1 genetic polymorphisms upon warfarin dose requirements in Egyptian patients with acute coronary syndrome.
Acute Coronary Syndrome
Impact of Cytochrome P450 2C19*2 and *3 on Clopidogrel Loading Dose in Saudi Patients with Acute Coronary Syndrome.
Acute Coronary Syndrome
microRNA-605 rs2043556 polymorphisms affect clopidogrel therapy through modulation of CYP2B6 and P2RY12 in acute coronary syndrome patients.
Acute Coronary Syndrome
Platelet reactivity in the early and late phases of acute coronary syndromes according to cytochrome P450 2C19 phenotypes.
Acute Coronary Syndrome
Polymorphisms of genes related to phase-I metabolic enzymes affecting the clinical efficacy and safety of clopidogrel treatment.
Acute Coronary Syndrome
Proton pump inhibitors and the risk of severe adverse events - A cardiovascular bombshell?
Acute Coronary Syndrome
The ABCB1, CYP2C19, CYP3A5 and CYP4F2 genetic polymorphisms and platelet reactivity in the early phases of acute coronary syndromes.
Acute Coronary Syndrome
The efficacy and safety of CYP2C19 genotype-guided antiplatelet therapy compared with conventional antiplatelet therapy in patients with acute coronary syndrome or undergoing percutaneous coronary intervention: A meta-analysis of randomized controlled trials.
Acute Coronary Syndrome
[Correlation between cytochrome 3A4+894C>T P450 gene polymorphism and outcomes of coronary intervention in patients with acute coronary syndrome].
Acute Coronary Syndrome
[Resistance to antiplatelet drugs in patients with cerebrovascular disorders].
Acute Kidney Injury
A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury.
Acute Kidney Injury
Acute kidney injury in patients with inactive cytochrome P450 polymorphisms.
Acute Kidney Injury
Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s.
Acute Kidney Injury
Analysis of the toxic effects of linoleic acid, 12,13-cis-epoxyoctadecenoic acid, and 12,13-dihydroxyoctadecenoic acid in rabbit renal cortical mitochondria.
Acute Kidney Injury
beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism.
Acute Kidney Injury
CYP2J2-produced epoxyeicosatrienoic acids attenuate ischemia/reperfusion-induced acute kidney injury by activating the SIRT1-FoxO3a pathway.
Acute Kidney Injury
Down-regulation of hepatic cytochrome P450 enzymes associated with cisplatin-induced acute renal failure in male rats.
Acute Kidney Injury
Effect of renal ischaemia/reperfusion-induced acute kidney injury on pharmacokinetics of midazolam in rats.
Acute Kidney Injury
Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of 2-(allylthio) pyrazine, a chemoprotective agent, in rats: the role of CYP3A23 induction.
Acute Kidney Injury
Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation.
Acute Kidney Injury
Effects of acute renal failure on the pharmacokinetics of chlorzoxazone in rats.
Acute Kidney Injury
Effects of acute renal failure on the pharmacokinetics of telithromycin in rats: negligible effects of increase in CYP3A1 on the metabolism of telithromycin.
Acute Kidney Injury
Effects of CYP3A5 polymorphism on the pharmacokinetics of a once-daily modified-release tacrolimus formulation and acute kidney injury in hematopoietic stem cell transplantation.
Acute Kidney Injury
Effects of glucose on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate.
Acute Kidney Injury
Effects of recombinant human growth hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate.
Acute Kidney Injury
Faster clearance of mirodenafil in rats with acute renal failure induced by uranyl nitrate: contribution of increased protein expression of hepatic CYP3A1 and intestinal CYP1A1 and 3A1/2.
Acute Kidney Injury
Faster clearance of omeprazole in rats with acute renal failure induced by uranyl nitrate: contribution of increased expression of hepatic cytochrome P450 (CYP) 3A1 and intestinal CYP1A and 3A subfamilies.
Acute Kidney Injury
Increase in urea in conjunction with L-arginine metabolism in the liver leads to induction of cytochrome P450 2E1 (CYP2E1): the role of urea in CYP2E1 induction by acute renal failure.
Acute Kidney Injury
Induction of P450 1A by 3-methylcholanthrene protects mice from aristolochic acid-I-induced acute renal injury.
Acute Kidney Injury
Inhibition of cytochrome P450 2E1 and activation of transcription factor Nrf2 are renoprotective in myoglobinuric acute kidney injury.
Acute Kidney Injury
Pharmacogenomic associations in ABCB1 and CYP3A5 with acute kidney injury and chronic kidney disease after myeloablative hematopoietic cell transplantation.
Acute Kidney Injury
Pharmacokinetic changes of drugs in rat model of acute renal failure induced by uranyl nitrate: correlation between drug metabolism and hepatic microsomal cytochrome P450 isozymes.
Acute Kidney Injury
Pharmacokinetic changes of intravenous 2-(allylthio) pyrazine, a chemoprotective agent, in rats with acute renal failure induced by uranyl nitrate.
Acute Kidney Injury
Romidepsin (FK228) in a Mouse Model of Lipopolysaccharide-Induced Acute Kidney Injury is Associated with Down-Regulation of the CYP2E1 Gene.
Acute Kidney Injury
The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison.
Acute Kidney Injury
Ticagrelor and Statin Interaction Induces Rhabdomyolysis and Acute Renal Failure: Case reports and Scoping Review.
Acute Lung Injury
Knockout of cytochrome P450 1A1 enhances lipopolysaccharide-induced acute lung injury in mice by targeting NF-?B activation.
Acute Lung Injury
Modulation of Pulmonary Cytochrome P4501A1 Expression by Hyperoxia and Inhaled Nitric Oxide in the Newborn Rat: Implications for Lung Injury.
Acute-On-Chronic Liver Failure
Effects of plasma from patients with acute on chronic liver failure on function of cytochrome P450 in immortalized human hepatocytes.
Addison Disease
Adrenal-cortex autoantibodies and steroid-producing cells autoantibodies in patients with Addison's disease: comparison of immunofluorescence and immunoprecipitation assays.
Addison Disease
Autoantibodies to adrenal cytochrome P450 antigens in isolated Addison's disease and autoimmune polyendocrine syndrome type II.
Addison Disease
Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease.
Addison Disease
Autoimmunity to steroid-producing cells and familial polyendocrine autoimmunity.
Addison Disease
Identification of the main gonadal autoantigens in patients with adrenal insufficiency and associated ovarian failure.
Addison Disease
Immunological cross-reactivity to multiple autoantigens in patients with liver kidney microsomal type 1 autoimmune hepatitis.
Addison Disease
Mechanism of inhibition of cytochrome P450 C21 enzyme activity by autoantibodies from patients with Addison's disease.
Addison Disease
Premature Ovarian Failure in Patients with Autoimmune Addison's Disease: Clinical, Genetic, and Immunological Evaluation.
Addison Disease
Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease.
adenine phosphoribosyltransferase deficiency
Ultra-rare renal diseases diagnosed with whole-exome sequencing: Utility in diagnosis and management.
Adenocarcinoma
8-Methoxypsoralen, a potent human CYP2A6 inhibitor, inhibits lung adenocarcinoma development induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.
Adenocarcinoma
A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma.
Adenocarcinoma
A population-based, case-control study of polymorphisms in carcinogen-metabolizing genes, smoking, and pancreatic adenocarcinoma risk.
Adenocarcinoma
A practical method to determine the amount of tissue to analyze using laser scanning cytometry.
Adenocarcinoma
A specific African-American CYP1A1 polymorphism is associated with adenocarcinoma of the lung.
Adenocarcinoma
Altered regulation of the cytochrome P4501A1 gene: novel inducer-independent gene expression in pulmonary carcinoma cell lines.
Adenocarcinoma
Association of a genetic variant of CYP19A1 with multicentric development of lung adenocarcinomas.
Adenocarcinoma
Association of aryl hydrocarbon receptor and cytochrome P4501B1 expressions in human non-small cell lung cancers.
Adenocarcinoma
Association of cigarette smoking and CYP1A1 polymorphisms with adenocarcinoma of the lung by grades of differentiation.
Adenocarcinoma
Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells.
Adenocarcinoma
Bioinformatics and functional analyses of key genes in smoking-associated lung adenocarcinoma.
Adenocarcinoma
Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics.
Adenocarcinoma
Cumulative Evidence for Associations between Genetic Variants and Risk of Esophageal Cancer.
Adenocarcinoma
CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells.
Adenocarcinoma
CYP19 (aromatase cytochrome P450) gene expression in human malignant endometrial tumors.
Adenocarcinoma
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung.
Adenocarcinoma
CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population.
Adenocarcinoma
CYP1B1 Polymorphisms and K-ras Mutations in Patients with Pancreatic Ductal Adenocarcinoma.
Adenocarcinoma
CYP2A6 overexpression in human lung cancers correlates with a high malignant status.
Adenocarcinoma
CYP2D6 genotype and lung cancer risk according to histologic type and tobacco exposure.
Adenocarcinoma
CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma.
Adenocarcinoma
Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development.
Adenocarcinoma
Cytochrome P450 2E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation.
Adenocarcinoma
Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N'-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolism.
Adenocarcinoma
Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk.
Adenocarcinoma
Differential Expression of Cytochrome P450 Omega-hydroxylase Isoforms and Their Association with Clinicopathological Features in Pancreatic Ductal Adenocarcinoma.
Adenocarcinoma
Down-regulated expression of cytochrome P450 (CYP) involved in the development and progression of esophageal adenocarcinoma.
Adenocarcinoma
Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples.
Adenocarcinoma
Effects of cytochrome P450 (CYP) 2A6 gene deletion and CYP2E1 genotypes on gastric adenocarcinoma.
Adenocarcinoma
Evolution of Hominin Detoxification: Neanderthal and Modern Human Ah Receptor Respond Similarly to TCDD.
Adenocarcinoma
Features of the Copy Number Variation of Certain Genes in Tumor Cells in Patients with Serous Ovarian Adenocarcinoma.
Adenocarcinoma
Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County.
Adenocarcinoma
Glucocorticoid-induced pancreatic-hepatic trans-differentiation in a human cell line in vitro.
Adenocarcinoma
GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas.
Adenocarcinoma
GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma.
Adenocarcinoma
Hypomethylation of the XRE -1383 site is associated with the upregulation of CYP1A1 in gastric adenocarcinoma.
Adenocarcinoma
Identification of key genes in endometrioid endometrial adenocarcinoma via TCGA database.
Adenocarcinoma
Immunohistochemical localization of cytochrome P450 2E1 in human pulmonary carcinoma and normal bronchial tissue.
Adenocarcinoma
Induction of cytochrome P450 1A1 gene expression by a vitamin K3 analog in mouse hepatoma Hepa-1c1c7 cells.
Adenocarcinoma
Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer.
Adenocarcinoma
Lung cancer and CYP2D6 (the debrisoquine polymorphism): sources of heterogeneity in the proposed association.
Adenocarcinoma
Lung cancer risk in African-Americans in relation to a race-specific CYP1A1 polymorphism.
Adenocarcinoma
Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation.
Adenocarcinoma
Molecular epidemiology: a new perspective for the study of toxic exposures in man. A consideration of the influence of genetic susceptibility factors on risk in different lung cancer histologies.
Adenocarcinoma
No association between polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the risk of gastric adenocarcinoma in the European prospective investigation into cancer and nutrition.
Adenocarcinoma
Omeprazole induces NAD(P)H quinone oxidoreductase 1 via aryl hydrocarbon receptor-independent mechanisms: Role of the transcription factor nuclear factor erythroid 2-related factor 2.
Adenocarcinoma
Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct.
Adenocarcinoma
Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.
Adenocarcinoma
p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines.
Adenocarcinoma
Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.
Adenocarcinoma
Polymorphism of metabolizing genes and lung cancer histology: prevalence of CYP2E1 in adenocarcinoma.
Adenocarcinoma
Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma.
Adenocarcinoma
Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition.
Adenocarcinoma
Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.
Adenocarcinoma
Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma.
Adenocarcinoma
Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas.
Adenocarcinoma
Requirement of aryl hydrocarbon receptor overexpression for CYP1B1 up-regulation and cell growth in human lung adenocarcinomas.
Adenocarcinoma
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Adenocarcinoma
Salvia fruticosa Modulates mRNA Expressions and Activity Levels of Xenobiotic Metabolizing CYP1A2, CYP2E1, NQO1, GPx, and GST Enzymes in Human Colorectal Adenocarcinoma HT-29 Cells.
Adenocarcinoma
Sulfated extract of Abelmoschus esculentus: A potential cancer chemopreventive agent.
Adenocarcinoma
Synergistic association of CYP1A1 polymorphisms with increased susceptibility to squamous cell lung cancer in north Indian smokers.
Adenocarcinoma
The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis.
Adenocarcinoma
Three different stable human breast adenocarcinoma sublines that overexpress ALDH3A1 and certain other enzymes, apparently as a consequence of constitutively upregulated gene transcription mediated by transactivated EpREs (electrophile responsive elements) present in the 5'-upstream regions of these genes.
Adenocarcinoma
Transcriptional regulation of the human CYP1B1 gene. Evidence for involvement of an aryl hydrocarbon receptor response element in constitutive expression.
Adenocarcinoma
Transcriptome sequencing identifies key pathways and genes involved in gastric adenocarcinoma.
Adenocarcinoma
Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer.
Adenocarcinoma of Lung
8-Methoxypsoralen, a potent human CYP2A6 inhibitor, inhibits lung adenocarcinoma development induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.
Adenocarcinoma of Lung
A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population.
Adenocarcinoma of Lung
Analysis of genomic and transcriptomic variations as prognostic signature for lung adenocarcinoma.
Adenocarcinoma of Lung
Association between the CYP2E1 polymorphisms and lung cancer risk: a meta-analysis.
Adenocarcinoma of Lung
Association of GSTM1, CYP1A1 and CYP2E1 genetic polymorphisms with susceptibility to lung adenocarcinoma: a case-control study in Chinese population.
Adenocarcinoma of Lung
Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers.
Adenocarcinoma of Lung
Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility.
Adenocarcinoma of Lung
CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis.
Adenocarcinoma of Lung
CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women.
Adenocarcinoma of Lung
CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma.
Adenocarcinoma of Lung
CYP3A5 suppresses metastasis of lung adenocarcinoma through ATOH8/Smad1 axis.
Adenocarcinoma of Lung
Cytochrome P4501A2 (CYP1A2) activity and lung cancer risk: a preliminary study among Chinese women in Singapore.
Adenocarcinoma of Lung
Epigenetic regulation of vitamin D metabolism in human lung adenocarcinoma.
Adenocarcinoma of Lung
Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5.
Adenocarcinoma of Lung
Induction of cytochromes P450 1A1 and 1B1 in human lung adenocarcinoma CL5 cells by frying-meat emission particulate.
Adenocarcinoma of Lung
Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans.
Adenocarcinoma of Lung
Involvement of oxidative stress and activation of aryl hydrocarbon receptor in elevation of CYP1A1 expression and activity in lung cells and tissues by arsenic: an in vitro and in vivo study.
Adenocarcinoma of Lung
Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2.
Adenocarcinoma of Lung
Prognostic and therapeutic implications of aromatase expression in lung adenocarcinomas with EGFR mutations.
Adenocarcinoma of Lung
Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells.
Adenocarcinoma of Lung
Requirement of aryl hydrocarbon receptor overexpression for CYP1B1 up-regulation and cell growth in human lung adenocarcinomas.
Adenocarcinoma of Lung
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Adenocarcinoma of Lung
Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK.
Adenocarcinoma of Lung
The cytochrome P450 enzyme CYP24A1 increases proliferation of mutant KRAS-dependent lung adenocarcinoma independently of its catalytic activity.
Adenocarcinoma of Lung
The expression levels of CYP3A4 and CYP3A5 serve as potential prognostic biomarkers in lung adenocarcinoma.
Adenocarcinoma of Lung
[Applications of aryl hydrocarbon hydroxylase in diagnosis of lung cancer]
Adenocarcinoma, Bronchiolo-Alveolar
Liposome mediated-CYP1A1 gene silencing nanomedicine prepared using lipid film-coated proliposomes as a potential treatment strategy of lung cancer.
Adenocarcinoma, Bronchiolo-Alveolar
Requirement of aryl hydrocarbon receptor overexpression for CYP1B1 up-regulation and cell growth in human lung adenocarcinomas.
Adenoma
8-Methoxypsoralen, a potent human CYP2A6 inhibitor, inhibits lung adenocarcinoma development induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.
Adenoma
A prospective study of genetic polymorphisms in the cytochrome P-450 2C9 enzyme and the risk for distal colorectal adenoma.
Adenoma
Alterations in expression of CYP1A1 and NADPH-cytochrome P450 reductase during lung tumor development in SWR/J mice.
Adenoma
Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors.
Adenoma
Aromatase cytochrome P450 enzyme expression in prolactinomas and its relationship to tumor behavior.
Adenoma
Aromatase p450 expression in a feminizing adrenal adenoma presenting as isosexual precocious puberty.
Adenoma
Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma.
Adenoma
Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models.
Adenoma
CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenoma.
Adenoma
CYP1A1, GSTM1, GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men.
Adenoma
CYP1A2 164 A-->C polymorphism, cigarette smoking, consumption of well-done red meat and risk of developing colorectal adenomas and carcinomas.
Adenoma
CYP24A1 and CYP27B1 Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence.
Adenoma
CYP2C9 and UGT1A6 genotypes modulate the protective effect of aspirin on colon adenoma risk.
Adenoma
CYP2C9 variants increase risk of colorectal adenoma recurrence and modify associations with smoking but not aspirin treatment.
Adenoma
Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation.
Adenoma
Cytochrome P450 2C9 Variants Influence Response to Celecoxib for Prevention of Colorectal Adenoma.
Adenoma
Decreased expression of cytochrome P450 protein in non-malignant colonic tissue of patients with colonic adenoma.
Adenoma
Decreased levels of steroid 21-hydroxylase [P450(c21)] and its mRNA in an adrenocortical adenoma associated with 21-hydroxylase deficiency.
Adenoma
Diminished CYP2E1 expression and formation of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1,1-dichloroethylene epoxide, in murine lung tumors.
Adenoma
Disordered expression of adrenal steroidogenic P450 mRNAs in incidentally discovered nonfunctioning adrenal adenoma.
Adenoma
Effects of ammonium perfluorooctanoate on Leydig cell function: in vitro, in vivo, and ex vivo studies.
Adenoma
Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria.
Adenoma
Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk.
Adenoma
Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas.
Adenoma
Genetic polymorphisms of CYP2E1 and risk of colorectal adenomas in the Self Defense Forces Health Study.
Adenoma
Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia.
Adenoma
GSTM1 and CYP2D6 genotype frequencies in patients with pituitary tumours: effects on P53, ras and gsp.
Adenoma
Heterocyclic amine intake, smoking, cytochrome P450 1A2 and N-acetylation phenotypes, and risk of colorectal adenoma in a multiethnic population.
Adenoma
Immunohistochemical detection of CYP2E1 and 2-S-glutathionyl acetate in murine lung tumors: diminished formation of reactive intermediates of 1,1-dichloroethylene.
Adenoma
Induction of colon adenocarcinomas in CD rats and lung adenomas in ICR mice by 6-nitrochrysene: comparison of carcinogenicity and aryl hydrocarbon hydroxylase induction in the target organs of each species.
Adenoma
Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk.
Adenoma
Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.
Adenoma
Metabolic proficiency and benzo[a]pyrene DNA adduct formation in APCMin mouse adenomas and uninvolved mucosa.
Adenoma
Mild cutaneous manifestation in two young women with extraordinary hyperandrogenemia.
Adenoma
No association between cytochrome P450 and glutathione S-transferase gene polymorphisms and risk of colorectal adenoma: results from the UK Flexible Sigmoidoscopy Screening Trial.
Adenoma
Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.
Adenoma
Polymorphisms in heterocyclic aromatic amines metabolism-related genes are associated with colorectal adenoma risk.
Adenoma
The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis.
Adenoma
The CYP1A2-164A-->C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans.
Adenoma
The effect of fenbuconazole on cell proliferation and enzyme induction in the liver of female CD1 mice.
Adenoma
Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer.
Adenoma
Using a combination of cytochrome P450 1B1 and beta-catenin for early diagnosis and prevention of colorectal cancer.
Adenoma
Vitamin D Receptor Genotype, Vitamin D3 Supplementation, and Risk of Colorectal Adenomas: A Randomized Clinical Trial.
Adenoma, Liver Cell
Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma.
Adenoma, Liver Cell
Hepatic CYP1A2 activity in liver tumors and the implications for preoperative volume-function analysis.
Adenoma, Pleomorphic
The role of aryl hydrocarbon receptor (AhR) in the pathology of pleomorphic adenoma in parotid gland.
Adenomatous Polyposis Coli
Cell lines from the same cervical carcinoma but with different radiosensitivities exhibit different cDNA microarray patterns of gene expression.
Adenomatous Polyposis Coli
Effects of polymorphic cytochrome P450 2A6 genotypes on chemoprevention against colorectal tumors in single Japanese cohort using daily low-dose aspirin: insights into future personalized treatments.
Adenomatous Polyposis Coli
Phenotype of cytochrome P450 CYP2D6 in patients with familial adenomatous polyposis.
Adenomatous Polyps
CYP27A1 and CYP24 expression as a function of malignant transformation in the colon.
Adenomyosis
COMT 158G/A and CYP1B1 432C/G polymorphisms increase the risk of endometriosis and adenomyosis: a meta-analysis.
Adenomyosis
CYP17, CYP1A1 and COMT polymorphisms and the risk of adenomyosis and endometriosis in Taiwanese women.
Adenomyosis
Endometrial aromatase mRNA as a possible screening tool for advanced endometriosis and adenomyosis.
Adenomyosis
Estrogen degrades Scribble in endometrial epithelial cells through E3 ubiquitin ligase HECW1 in the development of diffuse adenomyosis.
Adenomyosis
Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis.
Adenomyosis
Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium.
Adenomyosis
Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in eutopic endometrium from women with endometriosis, adenomyosis, or leiomyomas.
Adenomyosis
High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome.
Adenomyosis
Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium.
Adenomyosis
[Role of estrogen, estrogen receptors, and aromatase in the pathogenesis of uterine adenomyosis].
Adenoviridae Infections
Chemical induced inflammation of the liver breaks tolerance and results in autoimmune hepatitis in Balb/c mice.
Adenoviridae Infections
Evaluation of the HC-04 cell line as an in vitro model for mechanistic assessment of changes in hepatic cytochrome P450 3A during adenovirus infection.
Adrenal Hyperplasia, Congenital
17??hydroxylase/17,20?lyase deficiency in congenital adrenal hyperplasia: A case report.
Adrenal Hyperplasia, Congenital
21-Hydroxylase deficiency: from molecular genetics to clinical presentation.
Adrenal Hyperplasia, Congenital
A novel mutation in CYP17A1 gene leads to congenital adrenal hyperplasia: A case report.
Adrenal Hyperplasia, Congenital
A Three-dimensional Structure of Steroid 21-Hydroxylase (Cytochrome P450 21A2) with Two Substrates Reveals Locations of Disease-associated Variants.
Adrenal Hyperplasia, Congenital
Clinical presentation and mutational spectrum in a series of 166 patients with classical 21-hydroxylase deficiency from South China.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia and the function of adrenal medulla.
Adrenal Hyperplasia, Congenital
Continuous subcutaneous hydrocortisone infusion (CSHI) in a young adolescent with congenital adrenal hyperplasia (CAH).
Adrenal Hyperplasia, Congenital
Frequent deletion and duplication of the steroid 21-hydroxylase genes.
Adrenal Hyperplasia, Congenital
Glucocorticoid-induced osteoporosis in children with 21-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.
Adrenal Hyperplasia, Congenital
Impact on CYP19A1 activity by mutations in NADPH cytochrome P450 oxidoreductase.
Adrenal Hyperplasia, Congenital
Junction site analysis of chimeric CYP21A1P/CYP21A2 genes in 21-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Long-term outcome of partial P450 side-chain cleavage enzyme deficiency in three brothers: the importance of early diagnosis.
Adrenal Hyperplasia, Congenital
Low frequency of CYP2B deletions in Brazilian patients with congenital adrenal hyperplasia due to 21-hydroxylas deficiency.
Adrenal Hyperplasia, Congenital
Measuring the structural impact of mutations on cytochrome P450 21A2, the major steroid 21-hydroxylase related to congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
Adrenal Hyperplasia, Congenital
P450 side-chain cleavage deficiency--a rare cause of congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Psychiatric manifestations in young females with congenital adrenal hyperplasia in Taiwan.
Adrenal Hyperplasia, Congenital
Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia.
Adrenal Hyperplasia, Congenital
Restoration of adrenal steroidogenesis by adenovirus-mediated transfer of human cytochromeP450 21-hydroxylase into the adrenal gland of21-hydroxylase-deficient mice.
Adrenal Hyperplasia, Congenital
Sequence analysis of CYP21A1P in a German population to aid in the molecular biological diagnosis of congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Steroidogenic enzyme expression within the adrenal cortex during early human gestation.
Adrenal Hyperplasia, Congenital
Structure-phenotype correlations of human CYP21A2 mutations in congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Two cases of 17?-hydroxylase/17,20-lyase deficiency caused by the CYP17A1 mutation.
Adrenal Hyperplasia, Congenital
Why is management of patients with classical congenital adrenal hyperplasia more difficult at puberty?
Adrenal Insufficiency
A novel entity of clinically isolated adrenal insufficiency caused by a partially inactivating mutation of the gene encoding for P450 side chain cleavage enzyme (CYP11A1).
Adrenal Insufficiency
Adrenal Insufficiency With Voriconazole and Inhaled/Intranasal Corticosteroids: Case Report and Systematic Review.
Adrenal Insufficiency
Delayed diagnosis of adrenal insufficiency in a patient with severe penoscrotal hypospadias due to two novel P450 side-change cleavage enzyme (CYP11A1) mutations (p.R360W; p.R405X).
Adrenal Insufficiency
Homozygous mutation of P450 side-chain cleavage enzyme gene (CYP11A1) in 46, XY patient with adrenal insufficiency, complete sex reversal, and agenesis of corpus callosum.
Adrenal Insufficiency
Hypoadrenalism is not associated with early mortality during tuberculosis treatment in Malawi.
Adrenal Insufficiency
Induction of cytochrome P450 2B1 in rat liver by the aromatase inhibitor aminoglutethimide.
Adrenal Insufficiency
Secondary adrenal insufficiency from steroid use and co-prescribing of cytochrome p450 3A4 inhibitors.
Adrenocortical Adenoma
Disordered expression of adrenal steroidogenic P450 mRNAs in incidentally discovered nonfunctioning adrenal adenoma.
Adrenocortical Carcinoma
2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells.
Adrenocortical Carcinoma
2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity?
Adrenocortical Carcinoma
Differential regulation of 3beta-hydroxysteroid dehydrogenase type II and 17alpha-hydroxylase/lyase P450 in human adrenocortical carcinoma cells by epidermal growth factor and basic fibroblast growth factor.
Adrenocortical Carcinoma
Effects of Neonicotinoids on Promoter-Specific Expression and Activity of Aromatase (CYP19) in Human Adrenocortical Carcinoma (H295R) and Primary Umbilical Vein Endothelial (HUVEC) Cells.
Adrenocortical Carcinoma
Estrogen biosynthesis in human H295 adrenocortical carcinoma cells.
Adrenocortical Carcinoma
Human Cytochrome P450 2W1 Is Not Expressed in Adrenal Cortex and Is Only Rarely Expressed in Adrenocortical Carcinomas.
Adrenocortical Carcinoma
Inhibition of human placental aromatase activity by hydroxylated polybrominated diphenyl ethers (OH-PBDEs).
Adrenocortical Carcinoma
Overexpression of cytochrome P450 2A6 in adrenocortical carcinoma.
Adrenocortical Carcinoma
Suppression of cytochrome P450 4B1: An early event in adrenocortical tumorigenesis.
Adrenogenital Syndrome
Biological aspects of cytochrome P450 and associated hydroxylation reactions.
Adrenoleukodystrophy
Case report of dysregulation of primary bile acid synthesis in a family with X-linked adrenoleukodystrophy.
Agenesis of Corpus Callosum
Homozygous mutation of P450 side-chain cleavage enzyme gene (CYP11A1) in 46, XY patient with adrenal insufficiency, complete sex reversal, and agenesis of corpus callosum.
Aggressive Periodontitis
Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status.
Aggressive Periodontitis
Influence of CYP1A1 rs1048943 on Short- and Long-term Outcomes of Non-surgical Periodontal Therapy for Generalised Aggressive Periodontitis.
Akathisia, Drug-Induced
SSRI-induced extrapyramidal side-effects and akathisia: implications for treatment.
Albinism
Fine mapping of a candidate gene for cool-temperature-induced albinism in ornamental kale.
alcohol dehydrogenase deficiency
Linking Dysregulated AMPK Signaling and ER Stress in Ethanol-Induced Liver Injury in Hepatic Alcohol Dehydrogenase Deficient Deer Mice.
Alcohol-Related Disorders
Genetic repeat polymorphism in the regulating region of CYP2E1: frequency and relationship with enzymatic activity in alcoholics.
Alcohol-Related Disorders
Mutations in the exons and exon-intron junction regions of human cytochrome P-4502E1 gene and alcoholism.
Alcohol-Related Disorders
Mutations in the Exons and Exon-Intron Junction Regions of Human Cytochrome P-4502E1 Gene and Alcoholism.
Alopecia
Novel insights into the pathways regulating the canine hair cycle and their deregulation in alopecia X.
Alopecia
Plausible drug interaction between cyclophosphamide and voriconazole via inhibition of CYP2B6.
Altitude Sickness
The activity, protein, and mRNA expression of CYP2E1 and CYP3A1 in rats after exposure to acute and chronic high altitude hypoxia.
Altitude Sickness
[Effect of high altitude hypoxia on the activity and protein expression of CYP2C9 and CYP2C19].
Alzheimer Disease
A review of smoking cessation: potentially risky effects on prescribed medications.
Alzheimer Disease
Alzheimer's disease: beware of interactions with cholinesterase inhibitors.
Alzheimer Disease
ApoE and CYP2D6 polymorphism with and without parkinsonism-dementia complex in the people of Chamorro, guam.
Alzheimer Disease
Association between rs10046, rs1143704, rs767199, rs727479, rs1065778, rs1062033, rs1008805, and rs700519 polymorphisms in aromatase (CYP19A1) gene and Alzheimer's disease risk: a systematic review and meta-analysis involving 11,051 subjects.
Alzheimer Disease
Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer's disease.
Alzheimer Disease
BCHE and CYP2D6 genetic variation in Alzheimer's disease patients treated with cholinesterase inhibitors.
Alzheimer Disease
Caffeine based measures of CYP1A2 activity correlate with oral clearance of tacrine in patients with Alzheimer's disease.
Alzheimer Disease
Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease.
Alzheimer Disease
CYP2D6 gene polymorphism as a probable risk factor for Alzheimer's disease and Parkinson's disease with dementia.
Alzheimer Disease
CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy Bodies or Alzheimer's disease.
Alzheimer Disease
CYP2D6 polymorphisms in Alzheimer's disease, with and without extrapyramidal signs, showing no apolipoprotein E epsilon 4 effect modification.
Alzheimer Disease
Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration.
Alzheimer Disease
Debrisoquine hydroxylase gene polymorphism frequencies in patients with amyotrophic lateral sclerosis.
Alzheimer Disease
Differential expression of cholesterol hydroxylases in Alzheimer's disease.
Alzheimer Disease
Do CYP3A and ABCB1 genotypes influence the plasma concentration and clinical outcome of donepezil treatment?
Alzheimer Disease
Donepezil plasma concentrations, CYP2D6 and CYP3A4 phenotypes, and cognitive outcome in Alzheimer's disease.
Alzheimer Disease
Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease.
Alzheimer Disease
Effect of CYP2D6 and CYP3A4 Genotypes on the Efficacy of Cholinesterase Inhibitors in Southern Chinese Patients With Alzheimer's Disease.
Alzheimer Disease
Effect of the CYP2D6 and APOE Polymorphisms on the Efficacy of Donepezil in Patients with Alzheimer's Disease: A Systematic Review and Meta-Analysis.
Alzheimer Disease
Elevated hepatic and depressed renal cytochrome P450 activity in the Tg2576 transgenic mouse model of Alzheimer's disease.
Alzheimer Disease
Genetic variation of CYP19 (aromatase) gene influences age at onset of Alzheimer's disease in women.
Alzheimer Disease
Human Cognitive Ability Is Modulated by Aromatase Availability in the Brain in a Sex-Specific Manner.
Alzheimer Disease
Impact of CYP2D6 and CYP3A4 genetic polymorphism on combined cholinesterase inhibitors and memantine treatment in mild to moderate Alzheimer's disease.
Alzheimer Disease
Impact of CYP2D6, CYP3A5, and ABCB1 Polymorphisms on Plasma Concentrations of Donepezil and Its Metabolite in Patients With Alzheimer Disease.
Alzheimer Disease
Impact of the CYP2D6 polymorphism on steady-state plasma concentrations and clinical outcome of donepezil in Alzheimer's disease patients.
Alzheimer Disease
Impact of the CYP2D6 single nucleotide polymorphism on the concentration of and therapeutic response to donepezil in mild-to-moderate Alzheimer's disease.
Alzheimer Disease
Influence of CYP2D6, CYP3A5, ABCB1, APOE polymorphisms and nongenetic factors on donepezil treatment in patients with Alzheimer's disease and vascular dementia.
Alzheimer Disease
Influence of rs1080985 single nucleotide polymorphism of the CYP2D6 gene on response to treatment with donepezil in patients with alzheimer's disease.
Alzheimer Disease
Influence of the rs1080985 Single Nucleotide Polymorphism of the CYP2D6 Gene and APOE Polymorphism on the Response to Donepezil Treatment in Patients with Alzheimer's Disease in China.
Alzheimer Disease
Interaction between CYP19 aromatase and butyrylcholinesterase genes increases Alzheimer's disease risk.
Alzheimer Disease
Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity.
Alzheimer Disease
No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian population.
Alzheimer Disease
No association between familial Alzheimer disease and cytochrome P450 polymorphisms.
Alzheimer Disease
Parkinson's disease, but not Alzheimer's disease, Lewy body variant associated with mutant alleles at cytochrome P450 gene.
Alzheimer Disease
Pharmacogenetic Aspects of Therapy with Cholinesterase Inhibitors: The Role of CYP2D6 in Alzheimer's Disease Pharmacogenetics.
Alzheimer Disease
Pharmacogenetic basis for therapeutic optimization in Alzheimer's disease.
Alzheimer Disease
Plasma Lipids as Biomarkers for Alzheimer's Disease: A Systematic Review.
Alzheimer Disease
Polymorphism in Cytochrome P450 2D6, Glutathione S-Transferases Pi 1 Genes, and Organochlorine Pesticides in Alzheimer Disease: A Case-Control Study in North Indian Population.
Alzheimer Disease
Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease.
Alzheimer Disease
Proteomics analyses for the global proteins in the brain tissues of different human prion diseases.
Alzheimer Disease
Quantitative assessment of CYP2D6 polymorphisms and risk of Alzheimer's disease: a meta-analysis.
Alzheimer Disease
Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism.
Alzheimer Disease
Rate of cognitive decline in Alzheimer's disease is not affected by the alpha-1-antichymotrypsin A allele or the CYP2D6 B mutant.
Alzheimer Disease
Regional and cellular distribution of CYP2D subfamily members in rat brain.
Alzheimer Disease
Replication study to confirm the role of CYP2D6 polymorphism rs1080985 on donepezil efficacy in Alzheimer's disease patients.
Alzheimer Disease
Role of cytochrome P4502D6 functional polymorphisms in the efficacy of donepezil in patients with Alzheimer's disease.
Alzheimer Disease
Stereoselective metabolism of donepezil and steady-state plasma concentrations of S-donepezil based on CYP2D6 polymorphisms in the therapeutic responses of Han Chinese patients with Alzheimer's disease.
Alzheimer Disease
The CYP19A1 rs3751592 variant confers susceptibility to Alzheimer disease in the Chinese Han population.
Alzheimer Disease
The CYP2D6B allele is not overrepresented in a population of German patients with idiopathic Parkinson's disease.
Alzheimer Disease
The role of oestrogen in the pathogenesis of obesity, type 2 diabetes, breast cancer and prostate disease.
Alzheimer Disease
The roles of apolipoprotein E3 and CYP2D6 (rs1065852) gene polymorphisms in the predictability of responses to individualized therapy with donepezil in Han Chinese patients with Alzheimer's disease.
Alzheimer Disease
Variants in CYP17 and CYP19 cytochrome P450 genes are associated with onset of Alzheimer's disease in women with down syndrome.
Alzheimer Disease
[Is it personalized treatment of dementia based on the CYP2D6 gene polymorphism possible?]
Amebiasis
Identification of genes and pathways in esophageal adenocarcinoma using bioinformatics analysis.
Amebiasis
Screening and identification of potential target genes in head and neck cancer using bioinformatics analysis.
Amyotrophic Lateral Sclerosis
Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
AVP-923, a combination of dextromethorphan hydrobromide and quinidine sulfate for the treatment of pseudobulbar affect and neuropathic pain.
Amyotrophic Lateral Sclerosis
CYP1A2 rs762551 polymorphism and risk for amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Debrisoquine hydroxylase gene polymorphism frequencies in patients with amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Polymorphic sparteine metabolism and amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
[The excessive activity of cytochrome P450 system in ALS--the metabolic ratio of sparteine]
Anaphylaxis
Different expression patterns of hepatic cytochrome P450 s during anaphylactic or lipopolysaccharide-induced inflammation.
Anaphylaxis
[Effect of glycine on liver cytochrome P-450 and severity of experimental food anaphylaxis]
Anaphylaxis
[The effect of gamma-L-glutamylhistamine analogues on the severity of experimental anaphylactic reaction, hormonal status and liver cytochrome P450 system]
Androgen-Insensitivity Syndrome
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
Anemia
CYP2D6 Polymorphisms and the Safety and Gametocytocidal Activity of Single-Dose Primaquine for Plasmodium falciparum.
Anemia
Effect of erythropoietin on hepatic cytochrome P450 expression and function in an adenine-fed rat model of chronic kidney disease.
Anemia
Mycophenolic acid-related anemia and leucopenia in renal transplant recipients are related to genetic polymorphisms in CYP2C8.
Anemia
Revalidation of CoaguChek XS plus system for INR monitoring in Taiwanese patients: effects of clinical and genetic factors.
Anemia
Sickle Cell Anemia: Variants in the CYP2D6, CAT, and SLC14A1 Genes Are Associated With Improved Hydroxyurea Response.
Anemia
VDR gene polymorphisms impact on anemia at 2 weeks of anti-HCV therapy: a possible mechanism for early RBV-induced anemia.
Anemia, Aplastic
Cytochrome P4501A1 and glutathione S transferase gene polymorphisms in patients with aplastic anemia in India.
Anemia, Aplastic
Increased formation of DNA adducts in cultured fibroblasts of patients with aplastic anemia after in vitro incubation with benzo(a)pyrene.
Anemia, Aplastic
Study of the association between cytochromes P450 2D6 and 2E1 genotypes and the risk of drug and chemical induced idiosyncratic aplastic anaemia.
Anemia, Hemolytic
Pharmacogenetic testing in the Veterans Health Administration (VHA): policy recommendations from the VHA Clinical Pharmacogenetics Subcommittee.
Anemia, Sickle Cell
(281) Genetic variability of UGT2B7, CYP3A4, CYP3A5 and CYP2B6 DMETs in a sickle cell disease patient cohort.
Anemia, Sickle Cell
CYP2C9 Allelic Variants and Frequencies in a Pediatric Sickle Cell Disease Cohort: Implications for NSAIDs Pharmacotherapy.
Anemia, Sickle Cell
Cytochrome P450 2D6 Polymorphisms and Predicted Opioid Metabolism in African American Children With Sickle Cell Disease.
Anemia, Sickle Cell
Preemptive Genotyping of CYP2C8 and CYP2C9 Allelic Variants Involved in NSAIDs Metabolism for Sickle Cell Disease Pain Management.
Anemia, Sickle Cell
Sickle Cell Anemia: Variants in the CYP2D6, CAT, and SLC14A1 Genes Are Associated With Improved Hydroxyurea Response.
Anemia, Sickle Cell
The pharmacokinetics of codeine and its metabolites in Blacks with sickle cell disease.
Anencephaly
Quantitative evaluation of human placental aromatase in abnormal pregnancy--anencephalus and hydatidiform mole.
Angina, Stable
[The value of cytochrome P4502C19 gene assay for anti-platelet therapy after PCI in stable angina patients with left main coronary artery lesions].
Aniridia
Molecular characterization of Axenfeld-Rieger spectrum and other anterior segment dysgeneses in a sample of Mexican patients.
Aniridia
Molecular Characterization Of Newborn Glaucoma Including A Distinct Aniridic Phenotype.
Anovulation
In Search of New Therapeutics-Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond.
Anovulation
Targeted disruption of the aromatase P450 gene (Cyp19) in mice and their ovarian and uterine responses to 17beta-oestradiol.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
The pharmacogenomic association of Fc? receptors and cytochrome p450 enzymes and response to treatment with rituximab or cyclophosphamide in Anti-Neutrophil Cytoplasmic Antibody-Associated vasculitis.
Antley-Bixler Syndrome Phenotype
Akhenaten and the strange physiques of Egypt's 18th dynasty.
Antley-Bixler Syndrome Phenotype
Mouse Knockout of the Cholesterogenic Cytochrome P450 Lanosterol 14{alpha}-Demethylase (Cyp51) Resembles Antley-Bixler Syndrome.
Antley-Bixler Syndrome Phenotype
Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome.
Antley-Bixler Syndrome Phenotype
P450 oxidoreductase deficiency: a new disorder of steroidogenesis affecting all microsomal P450 enzymes.
Antley-Bixler Syndrome Phenotype
P450 Oxidoreductase deficiency: Analysis of mutations and polymorphisms.
Anus Neoplasms
Drug interactions between antineoplastic and antiretroviral therapies: Implications and management for clinical practice.
Aortic Aneurysm
Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice.
Aortic Aneurysm
The Effect of CYP1A1 and GSTP1 Isozymes on the Occurrence of Aortic Aneurysms.
Aortic Aneurysm, Abdominal
Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice.
Apnea
Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny.
Apnea
Induction of cytochrome P450 1A by cow milk-based formula: a comparative study between human milk and formula.
Argininosuccinic Aciduria
Ascorbic acid deficiency reduces the level of mRNA for cytochrome P-450 on the induction by polychlorinated biphenyls.
Argininosuccinic Aciduria
Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs.
aromatase deficiency
A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom).
aromatase deficiency
An Intron 9 CYP19 Gene Variant (IVS9+5G>A), Present in an Aromatase-Deficient Girl, Affects Normal Splicing and Is Also Present in Normal Human Steroidogenic Tissues.
aromatase deficiency
Aromatase deficiency and estrogen resistance: from molecular genetics to clinic.
aromatase deficiency
Aromatase deficiency caused by a novel P450arom gene mutation: impact of absent estrogen production on serum gonadotropin concentration in a boy.
aromatase deficiency
Aromatase Deficiency due to a Homozygous CYP19A1 Mutation in a 46,XX Egyptian Patient with Ambiguous Genitalia.
aromatase deficiency
Aromatase deficiency in a female who is compound heterozygote for two new point mutations in the P450arom gene: impact of estrogens on hypergonadotropic hypogonadism, multicystic ovaries, and bone densitometry in childhood.
aromatase deficiency
Aromatase deficiency: A case series of 46, XX Chinese children and a systematic review of the literature.
aromatase deficiency
Dysmetabolic syndrome in a man with a novel mutation of the aromatase gene: effects of testosterone, alendronate, and estradiol treatment.
aromatase deficiency
Human gene mutations. Gene symbol: CYP19. Disease: Aromatase deficiency.
aromatase deficiency
Hypothalamic-pituitary-ovarian axis during infancy, early and late prepuberty in an aromatase-deficient girl who is a compound heterocygote for two new point mutations of the CYP19 gene.
aromatase deficiency
Impact of estrogen replacement therapy in a male with congenital aromatase deficiency caused by a novel mutation in the CYP19 gene.
aromatase deficiency
Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries.
aromatase deficiency
The cytochrome P450 aromatase lacking exon 5 is associated with a phenotype of nonclassic aromatase deficiency and is also present in normal human steroidogenic tissues.
Arrhythmias, Cardiac
Bortezomib: new indication. Second-line treatment of myeloma: limited efficacy, major risks.
Arrhythmias, Cardiac
Cilostazol: new drug. Intermittent claudication: too little efficacy, too many risks.
Arrhythmias, Cardiac
Development of Robust 17(R),18(S)-Epoxyeicosatetraenoic Acid (17,18-EEQ) Analogues as Potential Clinical Antiarrhythmic Agents.
Arrhythmias, Cardiac
Domperidone, cytochrome P450 3A4 isoenzyme inhibitors and ventricular arrhythmia: a nationwide case-crossover study.
Arrhythmias, Cardiac
Integrated Isogenic Human Induced Pluripotent Stem Cell-Based Liver and Heart Microphysiological Systems Predict Unsafe Drug-Drug Interaction.
Arrhythmias, Cardiac
Optimal management of patients with non-ulcer dyspepsia: considerations for the treatment of the elderly.
Arrhythmias, Cardiac
QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients.
Arrhythmias, Cardiac
Review of Dextromethorphan 20 mg/Quinidine 10 mg (NUEDEXTA(®)) for Pseudobulbar Affect.
Arrhythmias, Cardiac
Role of cytochrome P450 genotype in the steps toward personalized drug therapy.
Arrhythmias, Cardiac
Urinary antispasmodic use and the risks of ventricular arrhythmia and sudden death in older patients.
Arrhythmias, Cardiac
[A new cause of torsades de pointes: combination of terfenadine and troleandomycin]
Arteriosclerosis
Different Effects of Polymorphic Flavin-Containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-Related Disease in a General Population in Japan.
Arthralgia
Letrozole concentration is associated with CYP2A6 variation but not with arthralgia in patients with breast cancer.
Arthralgia
Safety and tolerability of quinupristin/dalfopristin: administration guidelines.
Arthritis
17alpha-hydroxylase/C17-20 lyase cytochrome P450 mRNA expressions and enzyme activities during the development of arthritis in collagen-induced arthritis mice.
Arthritis
Changes in expression of hepatic cytochrome P450 subfamily enzymes during development of adjuvant-induced arthritis in rats.
Arthritis
DHEA metabolism in arthritis: a role for the p450 enzyme Cyp7b at the immune-endocrine crossroad.
Arthritis
Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver.
Arthritis
Murine collagen antibody induced arthritis (CAIA) and primary mouse hepatocyte culture as models to study cytochrome P450 suppression.
Arthritis
Profiling of hepatic metabolizing enzymes and nuclear receptors in rats with adjuvant arthritis by targeted proteomics.
Arthritis
The Effect of Infliximab on Hepatic Cytochrome P450 and Pharmacokinetics of Verapamil in Rats with Pre-Adjuvant Arthritis: A Drug-Disease and Drug-Drug Interaction.
Arthritis, Experimental
17alpha-hydroxylase/C17-20 lyase cytochrome P450 mRNA expressions and enzyme activities during the development of arthritis in collagen-induced arthritis mice.
Arthritis, Experimental
Analgesic and anti-inflammatory activity of 6-chloro-alpha-methyl-carbazole-2-acetic acid (C-5720).
Arthritis, Experimental
Drug-Disease Interaction: Effect of Inflammation and Nonsteroidal Anti-Inflammatory Drugs on Cytochrome P450 Metabolites of Arachidonic Acid.
Arthritis, Experimental
Effect of early phase adjuvant arthritis on hepatic P450 enzymes and pharmacokinetics of verapamil: an alternative approach to the use of an animal model of inflammation for pharmacokinetic studies.
Arthritis, Experimental
Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation and Inflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner.
Arthritis, Psoriatic
Cytochrome p450 1Al gene polymorphisms in patients with psoriatic arthritis.
Arthritis, Reactive
Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in reactive arthritis.
Arthritis, Rheumatoid
ABCB1 genetic variant and its associated tacrolimus pharmacokinetics affect renal function in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
CYP2D6 and CYP3A4 variants influence the risk and outcome of COVID-19 infection among rheumatoid arthritis patients maintained on hydroxychloroquine.
Arthritis, Rheumatoid
Development of a Physiologically Based Pharmacokinetic Model to Predict Disease-Mediated Therapeutic Protein-Drug Interactions: Modulation of Multiple Cytochrome P450 Enzymes by Interleukin-6.
Arthritis, Rheumatoid
Disease-Drug Interaction of Sarilumab and Simvastatin in Patients with Rheumatoid Arthritis.
Arthritis, Rheumatoid
Disease-Drug-Drug Interaction Involving Tocilizumab and Simvastatin in Patients With Rheumatoid Arthritis.
Arthritis, Rheumatoid
Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver.
Arthritis, Rheumatoid
Effects of Upadacitinib Coadministration on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates: A Study With the Modified Cooperstown 5+1 Cocktail.
Arthritis, Rheumatoid
Evaluation of disease-mediated therapeutic protein-drug interactions between an anti-interleukin-6 monoclonal antibody (sirukumab) and cytochrome P450 activities in a phase 1 study in patients with rheumatoid arthritis using a cocktail approach.
Arthritis, Rheumatoid
Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients.
Arthritis, Rheumatoid
Genetic polymorphism of CYP1A2 but not total or free teriflunomide concentrations is associated with leflunomide cessation in rheumatoid arthritis.
Arthritis, Rheumatoid
Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients.
Arthritis, Rheumatoid
Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Leflunomide induces NAD(P)H quinone dehydrogenase 1 enzyme via the aryl hydrocarbon receptor in neonatal mice.
Arthritis, Rheumatoid
Manganese superoxide dismutase and cytochrome P450 1A1 genes polymorphisms in rheumatoid arthritis in Taiwan.
Arthritis, Rheumatoid
Modeling therapeutic antibody-small molecule drug-drug interactions using a 3D perfusable human liver co-culture platform.
Arthritis, Rheumatoid
No significant effects of sodium aurothiomalate on haem metabolism and mixed function oxygenase activity in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Phenotype/genotype relationships for the cytochrome P450 enzyme CYP2D6 in rheumatoid arthritis: influence of drug therapy and disease activity.
Arthritis, Rheumatoid
Polymorphisms in cytochrome P450 2C19 enzyme and cessation of leflunomide in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Relationship between genotype for the cytochrome P450 CYP2D6 and susceptibility to ankylosing spondylitis and rheumatoid arthritis.
Arthritis, Rheumatoid
Semiphysiologically Based Pharmacokinetic Model of Leflunomide Disposition in Rheumatoid Arthritis Patients.
Arthritis, Rheumatoid
Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3.
Arthritis, Rheumatoid
Transcriptomic profiling as biological markers of depression - A pilot study in unipolar and bipolar women.
Asbestosis
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
Asbestosis
Decreased Cyp2E1 mRNA expression in human leucocytes in patients with fibrotic and inflammatory lung diseases.
Ascorbic Acid Deficiency
Increased CYP1A2 content and capacity to activate Glu-P-1 and Trp-P-2 in liver microsomes of scorbutic ODS rats.
Ascorbic Acid Deficiency
Ovarian aromatase activity in scorbutic mutant rats unable to synthesize ascorbic acid.
Ascorbic Acid Deficiency
Vitamin C deficiency increases the binucleation of hepatocytes in SMP30 knock-out mice.
Aspergillosis
Clinical Impact of Cytochrome P450 2C19 Genotype on the Treatment of Invasive Aspergillosis under Routine Therapeutic Drug Monitoring of Voriconazole in a Korean Population.
Aspergillosis
Drug-drug interactions between triazole antifungal agents used to treat invasive aspergillosis and immunosuppressants metabolized by cytochrome P450 3A4.
Aspergillosis
Voriconazole: new preparation. Invasive aspergillosis: benefits to be confirmed.
Asthenozoospermia
Abnormal arachidonic acid metabolic network may reduce sperm motility via P38 MAPK.
Asthma
Activation of aryl hydrocarbon receptor (AhR) in mesenchymal stem cells modulates macrophage polarization in asthma.
Asthma
Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats.
Asthma
Altered vulnerability to asthma at various levels of ambient Benzo[a]Pyrene by CTLA4, STAT4 and CYP2E1 polymorphisms.
Asthma
Association of matrix metalloproteinase 8 genetic polymorphisms with bronchial asthma in a Japanese population.
Asthma
Association of vitamin D gene polymorphisms in children with asthma - A systematic review.
Asthma
Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios.
Asthma
Associations Between Genetic Variants in Vitamin D Metabolism and Asthma Characteristics in Young African Americans: A Pilot Study.
Asthma
Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.
Asthma
Discovery of potential asthma targets based on the clinical efficacy of Traditional Chinese Medicine formulas.
Asthma
Fluticasone Propionate Pharmacogenetics: CYP3A4*22 Polymorphism and Pediatric Asthma Control.
Asthma
Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene-gene and gene-environment interactions for disease susceptibility.
Asthma
Glutathione- S-transferase micro and theta gene polymorphisms as new risk factors of atopic bronchial asthma.
Asthma
Herb-drug interactions: Effect of Ginkgo biloba extract on the pharmacokinetics of theophylline in rats.
Asthma
Identification of biomarkers in common chronic lung diseases by co-expression networks and drug-target interactions analysis.
Asthma
Increased expression and decreased activity of cytochrome P450 1A1 in a murine model of toluene diisocyanate-induced asthma.
Asthma
Pharmacogenetic Factors Affecting Asthma Treatment Response. Potential Implications for Drug Therapy.
Asthma
Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma.
Asthma
Steroid requirements and immune associations with vitamin D are stronger in children than adults with asthma.
Asthma
The relationship among IL-13, GSTP1, and CYP1A1 polymorphisms and environmental tobacco smoke in a population of children with asthma in Northern Mexico.
Asthma
Transporter-mediated hepatic uptake plays an important role in the pharmacokinetics and drug-drug interactions of montelukast.
Asthma
[PHARMACOGENETIC MARKERS OF THE EFFECTIVENESS OF TREATMENT OF CHILDREN WITH ATOPIC BRONCHIAL ASTHMA.]
Asthma
[Polymorphic genes of xenobiotic-metabolizing enzymes associated with bronchial asthma in genetically predisposed children]
Asthma
[Role of xenobiotic biotransformation enzymes in susceptibility to bronchial asthma and in formation of its clinical phenotypic features]
Asthma
[Significance of CYP2D6 oxidation genotype as a risk factor in development of allergic diseases]
Asthma, Aspirin-Induced
Characterization of six base pair deletion in the putative HNF1-binding site of human PXR promoter.
Astrocytoma
17?-estradiol induces temozolomide resistance through NRF2-mediated redox homeostasis in glioblastoma.
Astrocytoma
Astroglial CYP1B1 up-regulation in inflammatory/oxidative toxic conditions: IL-1beta effect and protection by N-acetylcysteine.
Astrocytoma
Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target.
Astrocytoma
Expression profile of cytochrome P450s and effects of polycyclic aromatic hydrocarbons and antiepileptic drugs on CYP1 expression in MOG-G-CCM cells.
Astrocytoma
Human brain cytochrome P450 1B1: immunohistochemical localization in human temporal lobe and induction by dimethylbenz(a)anthracene in astrocytoma cell line (MOG-G-CCM).
Astrocytoma
MGMT- and P450 3A-inhibitors do not sensitize glioblastoma cell cultures against nitrosoureas.
Astrocytoma
Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci.
Ataxia
Chinese patient with cerebrotendinous xanthomatosis confirmed by genetic testing: A case report and literature review.
Ataxia
Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9.
Ataxia
Possible Genetic Determinants of Response to Phenytoin in a Group of Colombian Patients With Epilepsy.
Atherosclerosis
?-Cryptoxanthin uptake in THP-1 macrophages upregulates the CYP27A1 signaling pathway.
Atherosclerosis
Acetylation phenotype and cytochrome P450IA2 phenotype are unlikely to be associated with peripheral arterial disease.
Atherosclerosis
Association of CYP1A1 Gene Polymorphism with Ischemic Stroke in South Indian Population.
Atherosclerosis
Common polymorphisms in CYP2C9, subclinical atherosclerosis and risk of ischemic vascular disease in 52,000 individuals.
Atherosclerosis
CYP1A1-mediated mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons.
Atherosclerosis
CYP2C8-derived epoxyeicosatrienoic acids decrease oxidative stress-induced endothelial apoptosis in development of atherosclerosis: Role of Nrf2 activation.
Atherosclerosis
CYP2E1 Gene Polymorphisms Related to the Formation of Coronary Artery Lesions in Kawasaki Disease.
Atherosclerosis
CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study.
Atherosclerosis
CYP2J2 Overexpression Increases EETs and Protects Against HFD-induced Atherosclerosis in ApoE-/- Mice.
Atherosclerosis
Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice.
Atherosclerosis
Cytochrome P450 and gene activation--cholesterol elimination and regression of atherosclerosis: author reply to the commentary.
Atherosclerosis
Cytochrome P450 and gene activation--from pharmacology to cholesterol elimination and regression of atherosclerosis.
Atherosclerosis
Cytochrome P450--physiological key factor against cholesterol accumulation and the atherosclerotic vascular process.
Atherosclerosis
Cytochrome P450: Polymorphisms and Roles in Cancer, Diabetes and Atherosclerosis
Atherosclerosis
Cytochromes CYP1A1 and CYP1B1: new pieces in the puzzle to understand the biomechanical paradigm of atherosclerosis.
Atherosclerosis
Discovery of novel drug candidates for inhibition of soluble epoxide hydrolase of arachidonic acid cascade pathway implicated in atherosclerosis.
Atherosclerosis
Downregulation of Cyp7a1 by Cholic Acid and Chenodeoxycholic Acid in Cyp27a1/ApoE Double Knockout Mice: Differential Cardiovascular Outcome.
Atherosclerosis
Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes.
Atherosclerosis
Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE-knockout mice.
Atherosclerosis
Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARgamma ligands.
Atherosclerosis
Hemolymph transcriptome analysis of Chinese mitten crab (Eriocheir sinensis) with intact, left cheliped autotomy and bilateral eyestalk ablation.
Atherosclerosis
Induction of cytochrome CYPIA1 and formation of toxic metabolites of benzo[a]pyrene by rat aorta: a possible role in atherogenesis.
Atherosclerosis
Marked inhibition of hepatic cytochrome P450 activity in cholesterol-induced atherosclerosis in rabbits.
Atherosclerosis
Polymorphisms of cytochrome P450 1A1, cigarette smoking and risk of coronary artery disease.
Atherosclerosis
Potential role of CYP1B1 in the development and treatment of metabolic diseases.
Atherosclerosis
Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta.
Atherosclerosis
Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects.
Atherosclerosis
Role of CYP2C9 polymorphism in phenytoin-related metabolic abnormalities and subclinical atherosclerosis in young adult epileptic patients.
Atherosclerosis
Smoking-gene interaction and disease development: relevance to pancreatic cancer and atherosclerosis.
Atherosclerosis
The atherogen 3-methylcholanthrene induces multiple DNA adducts in mouse aortic smooth muscle cells: role of cytochrome P4501B1.
Atherosclerosis
The secondary prevention of stroke according to cytochrome P450 2C19 genotype in patients with acute large-artery atherosclerosis stroke.
Atherosclerosis
Vitamin D Protects Against Atherosclerosis via Regulation of Cholesterol Efflux and Macrophage Polarization in Hypercholesterolemic Swine.
Atherosclerosis
[Statins: similarities and differences in the pharmacological, clinical and laboratory aspects]
Atrial Fibrillation
A new algorithm to predict warfarin dose from polymorphisms of CYP4F2 , CYP2C9 and VKORC1 and clinical variables: derivation in Han Chinese patients with non valvular atrial fibrillation.
Atrial Fibrillation
Caffeine intake reduces incident atrial fibrillation at a population level.
Atrial Fibrillation
Clinical application of a new warfarin-dosing regimen based on the CYP2C9 and VKORC1 genotypes in atrial fibrillation patients.
Atrial Fibrillation
CYP2C19*17 May Increase the Risk of Death Among Patients with an Acute Coronary Syndrome and Non-Valvular Atrial Fibrillation Who Receive Clopidogrel and Rivaroxaban.
Atrial Fibrillation
CYP2D6 Genotype-guided Metoprolol Therapy in Cardiac Surgery Patients: Rationale and Design of the Pharmacogenetic-guided Metoprolol Management for Postoperative Atrial Fibrillation in Cardiac Surgery (PREEMPTIVE) Pilot Study.
Atrial Fibrillation
DNA sensors to assess the effect of VKORC1 and CYP2C9 gene polymorphisms on warfarin dose requirement in Chinese patients with atrial fibrillation.
Atrial Fibrillation
Effects of different CYP2C19 genotypes on prognosis of patients complicated with atrial fibrillation taking clopidogrel after PCI.
Atrial Fibrillation
Effects of rare CYP2C9 alleles on stable warfarin doses in Chinese Han patients with atrial fibrillation.
Atrial Fibrillation
Evaluation of CYP2D6 oxidation of dextromethorphan and propafenone in a Chinese population with atrial fibrillation.
Atrial Fibrillation
Factors affecting the interindividual variability of warfarin dose requirement in adult Korean patients.
Atrial Fibrillation
G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving ?-blockers.
Atrial Fibrillation
Impact of ABCB1, ABCG2, and CYP3A5 polymorphisms on plasma trough concentrations of apixaban in Japanese patients with atrial fibrillation.
Atrial Fibrillation
Interactive Association Between CYP2C9 rs2860905 Polymorphism and Atrial Fibrillation on Ischemic Stroke in Taiwan Biobank Participants.
Atrial Fibrillation
Mineralocorticoid receptor, CYP11B2 mRNA expression, and atrial matrix remodelling in patients with atrial fibrillation.
Atrial Fibrillation
Non-vitamin K antagonist oral anticoagulants with amiodarone, P-glycoprotein inhibitors, or polypharmacy in patients with atrial fibrillation: Systematic review and meta-analysis.
Atrial Fibrillation
Pharmacogenetics of vitamin K antagonists and bleeding risk prediction in atrial fibrillation.
Atrial Fibrillation
Pharmacokinetics of novel atrial-selective antiarrhythmic agent vernakalant hydrochloride injection (RSD1235): influence of CYP2D6 expression and other factors.
Atrial Fibrillation
Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation.
Atrial Fibrillation
Prediction of stable acenocoumarol dose by a pharmacogenetic algorithm.
Atrial Fibrillation
Quantifying the Effect of Covariates on Concentrations and Effects of Steady-State Phenprocoumon Using a Population Pharmacokinetic/Pharmacodynamic Model.
Atrial Fibrillation
Should we test for CYP2C9 before initiating anticoagulant therapy in patients with atrial fibrillation?
Atrial Fibrillation
The influence of CYP2D6 polymorphism on the antiarrhythmic efficacy of propafenone in patients with paroxysmal atrial fibrillation during 3 months propafenone prophylactic treatment.
Atrial Fibrillation
Universal versus genotype-guided use of direct oral anticoagulants in atrial fibrillation patients: a decision analysis.
Atrial Fibrillation
Warfarin dose requirement with different genotypes of polymorphisms on CYP2C9 and VKORC1 and indications in Han-Chinese patients.
Atrial Fibrillation
Warfarin dosing according to the genotype-guided algorithm is most beneficial in patients with atrial fibrillation: a randomized parallel group trial.
Atrial Fibrillation
Warfarin pharmacogenetics: development of a dosing algorithm for Omani patients.
Atrial Fibrillation
[The influence of CYP2C9 genetic polymorphism on the pharmacokinetics and pharmacodynamics of warfarin in patients with constant atrial fibrillation]
Atrial Flutter
Pharmacokinetics of novel atrial-selective antiarrhythmic agent vernakalant hydrochloride injection (RSD1235): influence of CYP2D6 expression and other factors.
Atrioventricular Block
Exacerbation of atrioventricular block associated with concomitant use of amlodipine and aprepitant in a lung cancer patient: A case report.
Autoimmune Diseases
An Open-Label Study to Assess the Effect of Itraconazole and Rifampin on Parsaclisib Pharmacokinetics When Administered Orally in Healthy Participants.
Autoimmune Diseases
Association between Functional CYP2D6 Polymorphisms and Susceptibility to Autoimmune Diseases: A Meta-Analysis.
Autoimmune Diseases
Decreased Activity and Genetic Polymorphisms of CYP2C19 in Behçet's Disease.
Autoimmune Diseases
Effectiveness of Measuring Genetic Polymorphisms in Metabolizing Enzymes of Tacrolimus within One Medical Facility.
Autoimmune Diseases
Epitope mapping of human CYP1A2 in dihydralazine-induced autoimmune hepatitis.
Autoimmune Diseases
Imidazoacridinone antitumor agent C-1311 as a selective mechanism-based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Autoimmune Diseases
Polymorphisms of the xenobiotic-metabolizing enzymes CYP1A1 and NAT-2 in systemic sclerosis and lupus erythematosus.
Autoimmune Diseases
Possible role of cytochromes P450 in lupus erythematosus and related disorders.
Autoimmune Diseases
Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice.
Autoimmune Diseases
Synthesis, molecular modelling and CYP24A1 inhibitory activity of novel of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides.
Autoimmune Diseases
Target proteins in human autoimmunity: cytochromes P450 and UDP- glucuronosyltransferases.
Autoimmune Diseases
Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling.
Autoimmune Diseases
The CYP27B1 variant associated with an increased risk of autoimmune disease is underexpressed in tolerizing dendritic cells.
Autoimmune Diseases
Tienilic acid-induced autoimmune hepatitis: anti-liver and-kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9.
Autoimmune Diseases
Why oral opioids may not be effective in a subset of chronic pain patients.
Avitaminosis
VDR and CYP24A1 Expression Analysis in Iranian Relapsing-Remitting Multiple Sclerosis Patients.
Azoospermia
Association of CYP1A1*2A Polymorphism with Idiopathic Non-Obstructive Azoospermia in A South Indian Cohort.
Babesiosis
Downregulation of Hepatic Cytochrome P450 3A in Mice Infected with Babesia microti.
Babesiosis
Repression of Hepatic Cytochrome P450 2D Expression in Mice during Babesia microti Infection.
Bacterial Infections
Aryl hydrocarbon receptor protein and Cyp1A1 gene induction by LPS and phenanthrene in Atlantic cod (Gadus morhua) head kidney cells.
Bacterial Infections
Differential alterations in levels of hepatic microsomal cytochrome P450 isozymes following intracerebroventricular injection of bacterial lipopolysaccharide in rats.
Bacterial Infections
TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease.
Balkan Nephropathy
Genetic polymorphisms of cytochrome P450 among patients with Balkan endemic nephropathy (BEN).
Bardet-Biedl Syndrome
Novel variants in women with premature ovarian function decline identified via whole-exome sequencing.
Barrett Esophagus
Cytochromes P450 are expressed in proliferating cells in Barrett's metaplasia.
Barrett Esophagus
Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma.
Bartter Syndrome
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
Basal Cell Nevus Syndrome
Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome.
beta-Thalassemia
Modification of CYP2E1 and CYP3A4 activities in haemoglobin E-beta thalassemia patients.
Bile Duct Neoplasms
Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China.
Biliary Atresia
Immortalization of human hepatocytes from biliary atresia with CDK4R24C, cyclin D1, and TERT for cytochrome P450 induction testing.
Biliary Atresia
In vitro cytochrome p450 activity decreases in children with high pediatric end-stage liver disease scores.
Biliary Atresia
Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis.
Biliary Tract Neoplasms
Phase II study of S-1 combined with oxaliplatin as therapy for patients with metastatic biliary tract cancer: influence of the CYP2A6 polymorphism on pharmacokinetics and clinical activity.
Bisphosphonate-Associated Osteonecrosis of the Jaw
A SNP in CYP2C8 is not associated with the development of bisphosphonate-related osteonecrosis of the jaw in men with castrate-resistant prostate cancer.
Bisphosphonate-Associated Osteonecrosis of the Jaw
Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis.
Bisphosphonate-Associated Osteonecrosis of the Jaw
CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma.
Blepharospasm
CYP1A2 rs762551 and ADORA2A rs5760423 Polymorphisms in Patients with Blepharospasm.
Blindness
A novel methodology for enhanced and consistent heterologous expression of unmodified human cytochrome P450 1B1 (CYP1B1).
Blindness
Goniodysgenesis variability and activity of CYP1B1 genotypes in primary congenital glaucoma.
Blister
Hepatotoxicity of the herbal medicine germander: metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes.
Bone Diseases
Hypercalcemia, Hypercalciuria, and Elevated Calcitriol Concentrations with Autosomal Dominant Transmission Due to CYP24A1 Mutations: Effects of Ketoconazole Therapy.
Bone Diseases, Metabolic
The CYP3A4*18 genotype in the cytochrome P450 3A4 gene, a rapid metabolizer of sex steroids, is associated with low bone mineral density.
Bone Resorption
Roles for B[a]P and FICZ in subchondral bone metabolism and experimental temporomandibular joint osteoarthritis via the AhR/Cyp1a1 signaling axis.
Bone Resorption
Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes.
Bowen's Disease
Activation and overexpression of the aryl hydrocarbon receptor contribute to cutaneous squamous cell carcinomas: an immunohistochemical study.
Bradycardia
Association of CYP2D6 single-nucleotide polymorphism with response to ophthalmic timolol in primary open-angle Glaucoma--a pilot study.
Bradycardia
Cardiac toxicity of 5-ring polycyclic aromatic hydrocarbons is differentially dependent on the aryl hydrocarbon receptor 2 isoform during zebrafish development.
Bradycardia
Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny.
Bradycardia
Combining Antidepressants with ?-Blockers: Evidence of a Clinically Significant CYP2D6 Drug Interaction.
Bradycardia
CYP2D6 polymorphism and its impact on the clinical response to metoprolol: A systematic review and meta-analysis.
Bradycardia
Genetic variation in the CYP2D6 gene is associated with a lower heart rate and blood pressure in beta-blocker users.
Bradycardia
Profound metoprolol-induced bradycardia precipitated by acetaminophen-propoxyphene.
Bradycardia
Topical timolol for treatment of epistaxis in hereditary haemorrhagic telangiectasia associated with bradycardia: a look at CYP2D6 metabolising variants.
Bradycardia
[Pharmacokinetic risk factors of beta-blockers overdose in the elderly: Case report and pharmacology approach].
Bradycardia
[Relationship of blood aryl hydrocarbon receptor mRNA and cytochrome P450 1A1 mRNA expression with corrected QT interval among residents exposed to arsenic via drinking water].
Brain Diseases
Constitutive Androstane Receptor: A Peripheral and a Neurovascular Stress or Environmental Sensor.
Brain Diseases
Possible role of CYP2B6 genetic polymorphisms in ifosfamide-induced encephalopathy: report of three cases.
Brain Diseases
Recent examples on the clinical relevance of the CYP2D6 polymorphism and endogenous functionality of CYP2D6.
Brain Diseases
[Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced influenza-virus-associated encephalopathy]
Brain Edema
Involvement of CYP2E1 in the Course of Brain Edema Induced by Subacute Poisoning With 1,2-Dichloroethane in Mice.
Brain Edema
[Expression of CYP2E1 in different brain regions during the formation of toxic cerebral edema induced by 1, 2-DCE in mice and its effect on cerebral edema formation].
Brain Injuries
P450 Eicosanoids and Reactive Oxygen Species Interplay in Brain Injury and Neuroprotection.
Brain Injuries
Subarachnoid Hemorrhage Pattern Predicts Acute Cerebral Blood Flow Response in the Rat.
Brain Injuries, Traumatic
Differential effects of traumatic brain injury on the cytochrome p450 system: a perspective into hepatic and renal drug metabolism.
Brain Injuries, Traumatic
Effect of Traumatic Brain Injury, Erythropoietin, and Anakinra on Hepatic Metabolizing Enzymes and Transporters in an Experimental Rat Model.
Brain Injuries, Traumatic
Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system.
Brain Injuries, Traumatic
Impacts of Blast-Induced Traumatic Brain Injury on Expressions of Hepatic Cytochrome P450 1A2, 2B1, 2D1, and 3A2 in Rats.
Brain Injuries, Traumatic
Molecular Pathomechanisms of Impaired Flow-Induced Constriction of Cerebral Arteries Following Traumatic Brain Injury: A Potential Impact on Cerebral Autoregulation.
Brain Injuries, Traumatic
Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury.
Brain Ischemia
Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor.
Brain Ischemia
Cytochrome P450 CYP2E1 Suppression Ameliorates Cerebral Ischemia Reperfusion Injury.
Brain Ischemia
Interaction of clopidogrel and statins in secondary prevention after cerebral ischemia - a randomized, double-blind, double-dummy crossover-study.
Brain Ischemia
Pharmacogenomics of Cytochrome P450 of Nimodipine Metabolism After Aneurysmal Subarachnoid Hemorrhage.
Brain Ischemia
Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium.
Brain Ischemia
Soluble epoxide hydrolase inhibition provides multi-target therapeutic effects in rats after spinal cord injury.
Brain Neoplasms
A population-based case-control study of the CYP2D6 and GSTT1 polymorphisms and malignant brain tumors.
Brain Neoplasms
An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors.
Brain Neoplasms
Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm.
Brain Neoplasms
Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene.
Brain Neoplasms
Expression and induction of cytochrome P-450 1A1 and P-450 2D subfamily in the rat glioma C6 cell line.
Brain Neoplasms
Expression, induction and regulation of the cytochrome P450 monooxygenase system in the rat glioma C6 cell line.
Brain Neoplasms
Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors.
Brain Neoplasms
Glutathione S-Transferases and Cytochrome P450 Enzyme Expression in Patients with Intracranial Tumors: Preliminary Report of 55 Patients.
Brain Neoplasms
New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol.
Brain Neoplasms
Novel Functional Association of Serine Palmitoyltransferase Subunit 1-A Peptide in Sphingolipid Metabolism with Cytochrome P4501A1 Transactivation and Proliferative Capacity of the Human Glioma LN18 Brain Tumor Cell Line.
Brain Neoplasms
The potential effect of gender in CYP1A1 and GSTM1 genotype-specific associations with pediatric brain tumor.
Brain Neoplasms
The Role of Levetiracetam in Treatment of Seizures in Brain Tumor Patients.
Brain Neoplasms
Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system.
Brain Neoplasms
Transcriptional Effects of Dietary Exposure of Oil-Contaminated Calanus finmarchicus in Atlantic Herring (Clupea harengus).
Brain Neoplasms
Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors.
Breast Diseases
Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease.
Breast Neoplasms
1,25-Dihydroxyvitamin D3 inhibits growth of the breast cancer cell line MCF-7 and downregulates cytochrome P4501B1 through the COX-2/PGE2 pathway.
Breast Neoplasms
1-[(Benzofuran-2-yl)phenylmethyl]triazoles as steroidogenic inhibitors: synthesis and in vitro inhibition of human placental CYP19 aromatase.
Breast Neoplasms
12-O-tetradecanoylphorbol-13-acetate upregulates the Ah receptor and differentially alters CYP1B1 and CYP1A1 expression in MCF-7 breast cancer cells.
Breast Neoplasms
17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA.
Breast Neoplasms
2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates estradiol-induced aldehydic DNA lesions in human breast cancer cells through alteration of CYP1A1 and CYP1B1 expression.
Breast Neoplasms
2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the induction of DNA strand breaks and poly(ADP-ribose) polymerase-1 activation by 17beta-estradiol in human breast carcinoma cells through alteration of CYP1A1 and CYP1B1 expression.
Breast Neoplasms
2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
Breast Neoplasms
2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta.
Breast Neoplasms
27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression.
Breast Neoplasms
27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.
Breast Neoplasms
4-(3-Alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamides as new antimitotic prodrugs activated by cytochrome P450 1A1 in breast cancer cells.
Breast Neoplasms
4-Hydroxyphenylretinamide (4HPR) derivatives regulate aromatase activity and expression in breast cancer cells.
Breast Neoplasms
7-ethoxyresorufin O-deethylase (EROD) activity is not capable of reflecting the overall malignant potential of breast cancer tissue.
Breast Neoplasms
A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density.
Breast Neoplasms
A comprehensive examination of CYP19 variation and risk of breast cancer using two haplotype-tagging approaches.
Breast Neoplasms
A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort.
Breast Neoplasms
A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk.
Breast Neoplasms
A CYP1A1 restriction fragment length polymorphism is associated with breast cancer in African-American women.
Breast Neoplasms
A family-based genetic association study of variants in estrogen-metabolism genes COMT and CYP1B1 and breast cancer risk.
Breast Neoplasms
A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.
Breast Neoplasms
A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells.
Breast Neoplasms
A multigenic study on breast cancer risk associated with genetic polymorphisms of ER Alpha, COMT and CYP19 gene in BRCA1/BRCA2 negative Shanghai women with early onset breast cancer or affected relatives.
Breast Neoplasms
A penalized mixture model approach in genotype/phenotype association analysis for quantitative phenotypes.
Breast Neoplasms
A pooled analysis of CYP2D6 genotype in breast cancer prevention trials of low-dose tamoxifen.
Breast Neoplasms
A positive feedback pathway of estrogen biosynthesis in breast cancer cells is contained by resveratrol.
Breast Neoplasms
A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis.
Breast Neoplasms
A single-nucleotide polymorphism in the aromatase gene is associated with the efficacy of the aromatase inhibitor letrozole in advanced breast carcinoma.
Breast Neoplasms
A study on the association of cytochrome-P450 1A1 polymorphism and breast cancer risk in north Indian women.
Breast Neoplasms
A tetranucleotide repeat polymorphism in the CYP19 gene and breast cancer susceptibility in a Greek population exposed and not exposed to pesticides.
Breast Neoplasms
A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation.
Breast Neoplasms
A variant in the cytochrome p450 oxidoreductase gene is associated with breast cancer risk in African Americans.
Breast Neoplasms
Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells.
Breast Neoplasms
Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.
Breast Neoplasms
Activity Levels of Tamoxifen Metabolites at the Estrogen Receptor and the Impact of Genetic Polymorphisms of Phase I and II Enzymes on Their Concentration Levels in Plasma.
Breast Neoplasms
Additional Utility of Pharmacogenomics (PGx) Panel Testing in a CYP2D6 Normal Metabolizer with a History of Breast Cancer.
Breast Neoplasms
Adipose tissue PCB levels and CYP1B1 and COMT genotypes in relation to breast cancer risk in postmenopausal Danish women.
Breast Neoplasms
Adjusting the dose of tamoxifen in patients with early breast cancer and CYP2D6 poor metabolizer phenotype.
Breast Neoplasms
African American-preponderant single nucleotide polymorphisms (SNPs) and risk of breast cancer.
Breast Neoplasms
Age-related changes in mRNA levels of hepatic transporters, cytochrome P450 and UDP-glucuronosyltransferase in female rats.
Breast Neoplasms
Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions.
Breast Neoplasms
Amino alcohol acrylonitriles as broad spectrum and tumour selective cytotoxic agents.
Breast Neoplasms
Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells.
Breast Neoplasms
An optimized protocol for mRNA quantification using nested competitive RT-PCR.
Breast Neoplasms
Analysis of CYP17, CYP19 and CYP1A1 Gene Polymorphisms in Iranian Women with Breast Cancer.
Breast Neoplasms
Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies.
Breast Neoplasms
Analysis of the rs10046 polymorphism of aromatase (CYP19) in premenopausal onset of human breast cancer.
Breast Neoplasms
Androgens influence estrogen-induced responses in human breast carcinoma cells through cytochrome P450 aromatase.
Breast Neoplasms
Anti-tumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces single-strand breaks and DNA-protein cross-links in sensitive MCF-7 breast cancer cells.
Breast Neoplasms
Antiproliferative effect of the Ginkgo biloba extract is associated with the enhancement of cytochrome P450 1B1 expression in estrogen receptor-negative breast cancer cells.
Breast Neoplasms
Antiretroviral drug transporters and metabolic enzymes in human testicular tissue: potential contribution to HIV-1 sanctuary site.
Breast Neoplasms
Applications of polymorphisms and pharmacogenomics in obstetrics and gynecology.
Breast Neoplasms
Are health technology assessments of pharmacogenetic tests feasible? A case study of CYP2D6 testing in the treatment of breast cancer with tamoxifen.
Breast Neoplasms
Are pharmacogenomic biomarkers an effective tool to predict taxane toxicity and outcome in breast cancer patients? Literature review.
Breast Neoplasms
Aromatase (CYP19) expression in tumor-infiltrating lymphocytes and blood mononuclears.
Breast Neoplasms
Aromatase, CYP1B1 and Fatty Acid Synthase Expression in Breast Tumors of BRCA1 Mutation Carriers.
Breast Neoplasms
Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2, and GSTM1 in breast cancer.
Breast Neoplasms
Aryl hydrocarbon hydroxylase activity in mouse, rat, and human mammary tumors.
Breast Neoplasms
Aryl Hydrocarbon Receptor (AhR)-Active Pharmaceuticals Are Selective AhR Modulators in MDA-MB-468 and BT474 Breast Cancer Cells.
Breast Neoplasms
Aryl hydrocarbon receptor activation of an antitumor aminoflavone: basis of selective toxicity for MCF-7 breast tumor cells.
Breast Neoplasms
Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells.
Breast Neoplasms
Aryl Hydrocarbon Receptor-Dependent Metabolism Plays a Significant Role in Estrogen-Like Effects of Polycyclic Aromatic Hydrocarbons on Cell Proliferation.
Breast Neoplasms
Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane.
Breast Neoplasms
Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.
Breast Neoplasms
Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and ?-Catenin and Akt activation.
Breast Neoplasms
Assessment of the impact of CYP3A polymorphisms on the formation of ?-hydroxytamoxifen and N-desmethyltamoxifen in human liver microsomes.
Breast Neoplasms
Association between CYP19 polymorphisms and breast cancer risk: results from 10,592 cases and 11,720 controls.
Breast Neoplasms
Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment.
Breast Neoplasms
Association between CYP2D6 genotypes and the clinical outcomes of adjuvant tamoxifen for breast cancer: a meta-analysis.
Breast Neoplasms
Association between CYP2D6 polymorphisms and breast cancer outcomes.
Breast Neoplasms
Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.
Breast Neoplasms
Association between Genetic Polymorphisms of CYP2D6 and Outcomes in Breast Cancer Patients with Tamoxifen Treatment.
Breast Neoplasms
Association between polymorphisms in estrogen metabolism genes and breast cancer development in Chinese women: A prospective case-control study.
Breast Neoplasms
Association between telomere length and CYP19 TTTA repetition polymorphism in healthy and breast cancer-diagnosed women.
Breast Neoplasms
Association between the T27C polymorphism in the cytochrome P450 c17alpha (CYP17) gene and risk factors for breast cancer.
Breast Neoplasms
Association of cyclophosphamide drug-metabolizing enzyme polymorphisms and chemotherapy-related ovarian failure in breast cancer survivors.
Breast Neoplasms
Association of CYP19 polymorphisms with breast cancer risk: A case-control study.
Breast Neoplasms
Association of CYP1A1 A4889G and T6235C polymorphisms with the risk of sporadic breast cancer in Brazilian women.
Breast Neoplasms
Association of CYP1A1 M2 (A2455G) Polymorphism with Susceptibility to Breast Cancer in Mazandaran Province, Northern Iran: A Case-control Study.
Breast Neoplasms
Association of CYP1A1 polymorphisms with breast cancer in North Indian women.
Breast Neoplasms
Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study.
Breast Neoplasms
Association of CYP1B1 haplotypes and breast cancer risk in Caucasian women.
Breast Neoplasms
Association of CYP1B1 Polymorphisms with Breast Cancer: A Case-Control Study in the Han Population in Ningxia Hui Autonomous Region, P. R. China.
Breast Neoplasms
Association of CYP1B1 with hypersensitivity induced by Taxane therapy in breast cancer patients.
Breast Neoplasms
Association of CYP2D6 and CYP2C19 polymorphisms and disease-free survival of Thai post-menopausal breast cancer patients who received adjuvant tamoxifen.
Breast Neoplasms
Association of CYP2D6 genotype and tamoxifen metabolites with breast cancer recurrence in a low-dose trial.
Breast Neoplasms
Association of CYP2D6 metabolizer status with mammographic density change in response to tamoxifen treatment.
Breast Neoplasms
Association of CYP2D6*10 (c. 100 C>T) genotype with Z-END Concentration in Patients with Breast Cancer Receiving Tamoxifen Therapy in Indonesian Population.
Breast Neoplasms
Association of CYP2E1, STK15 and XRCC1 Polymorphisms with Risk of Breast Cancer in Malaysian Women.
Breast Neoplasms
Association of Cytochrome CYP1A1 Gene Polymorphisms and Tobacco Smoking With the Risk of Breast Cancer in Women From Iraq.
Breast Neoplasms
Association of cytochrome P450 1B1 (CYP1B1) polymorphism with steroid receptor status in breast cancer.
Breast Neoplasms
Association of cytochrome P450 genetic polymorphisms with neoadjuvant chemotherapy efficacy in breast cancer patients.
Breast Neoplasms
Association of genetic polymorphisms in CYP19 and CYP1A1 with the oestrogen receptor-positive breast cancer risk.
Breast Neoplasms
Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women.
Breast Neoplasms
Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients.
Breast Neoplasms
Association of polymorphic G1934A variant (allele *4) of CYP2D6 gene with increased risk of breast cancer development in Ukrainian women.
Breast Neoplasms
Association of single nucleotide polymorphisms in CYP1B1 and COMT genes with breast cancer susceptibility in Indian women.
Breast Neoplasms
Association of single nucleotide polymorphisms of cytochrome P450 enzymes with experience of vasomotor, vaginal and musculoskeletal symptoms among breast cancer patients: a systematic review.
Breast Neoplasms
Association of the genetic polymorphism of the CYP19 intron 4[TTTA]n repeat with familial prostate cancer risk in a Japanese population.
Breast Neoplasms
Associations between aromatase CYP19 rs10046 polymorphism and breast cancer risk: from a case-control to a meta-analysis of 20,098 subjects.
Breast Neoplasms
Associations between breast cancer susceptibility gene polymorphisms and clinicopathological features.
Breast Neoplasms
Associations between the CYP17, CYPIB1, COMT and SHBG polymorphisms and serum sex hormones in post-menopausal breast cancer survivors.
Breast Neoplasms
Astemizole Synergizes Calcitriol Antiproliferative Activity by Inhibiting CYP24A1 and Upregulating VDR: A Novel Approach for Breast Cancer Therapy.
Breast Neoplasms
Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism.
Breast Neoplasms
Benzo[a]pyrene-resistant MCF-7 human breast cancer cells. A unique aryl hydrocarbon-nonresponsive clone.
Breast Neoplasms
Berberine Activates Aryl Hydrocarbon Receptor but Suppresses CYP1A1 Induction through miR-21-3p Stimulation in MCF-7 Breast Cancer Cells.
Breast Neoplasms
Boron-Based 4-Hydroxytamoxifen Bioisosteres for Treatment of de Novo Tamoxifen Resistant Breast Cancer.
Breast Neoplasms
BRCA1 Breast Cancer Risk Is Modified by CYP19 Polymorphisms in Ashkenazi Jews.
Breast Neoplasms
Breast cancer and CYPIA1, GSTM1, and GSTT1 polymorphisms: evidence of a lack of association in Caucasians and African Americans.
Breast Neoplasms
Breast Cancer Association with CYP1A2 Activity and Gene Polymorphisms--a Preliminary Case-control Study in Tunisia.
Breast Neoplasms
Breast cancer recurrence risk related to concurrent use of SSRI antidepressants and tamoxifen.
Breast Neoplasms
Breast cancer risk associated with CYP1A1 genetic polymorphisms in Japanese women.
Breast Neoplasms
Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility.
Breast Neoplasms
Breast cancer risk associated with polymorphism in CYP19 in Japanese women.
Breast Neoplasms
Breast cancer risk, fungicide exposure and CYP1A1*2A gene-environment interactions in a province-wide case control study in Prince Edward Island, Canada.
Breast Neoplasms
Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes.
Breast Neoplasms
Breast cancer: Occluded role of mitochondria N-acetylserotonin/melatonin ratio in co-ordinating pathophysiology.
Breast Neoplasms
Breast density and polymorphisms in genes coding for CYP1A2 and COMT: the Multiethnic Cohort.
Breast Neoplasms
Calpain mediates the dioxin-induced activation and down-regulation of the aryl hydrocarbon receptor.
Breast Neoplasms
Camouflaged, activatable and therapeutic tandem bionanoreactors for breast cancer theranosis.
Breast Neoplasms
Can tamoxifen therapy be optimized for patients with breast cancer on the basis of CYP2D6 activity assessments?
Breast Neoplasms
Carbon Monoxide Inhibits Cytochrome P450 Enzymes CYP3A4/2C8 in Human Breast Cancer Cells, Increasing Sensitivity to Paclitaxel.
Breast Neoplasms
Cellular apoptosis susceptibility protein (CAS) suppresses the proliferation of breast cancer cells by upregulated cyp24a1.
Breast Neoplasms
Cellular Metabolism in High-Throughput In Vitro Reporter Gene Assays and Implications for the Quantitative In Vitro-In Vivo Extrapolation.
Breast Neoplasms
Changes in expression of drug-metabolizing enzymes by single-walled carbon nanotubes in human respiratory tract cells.
Breast Neoplasms
Characterization and Biological Potency of Mono- to Tetra-Halogenated Carbazoles.
Breast Neoplasms
Characterization of the isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution LC-MS, and quantitative HPLC analysis.
Breast Neoplasms
Chemosensitivity determinants of irinotecan hydrochloride in hepatocellular carcinoma cell lines.
Breast Neoplasms
Chrysoeriol Prevents TNF?-Induced CYP19 Gene Expression via EGR-1 Downregulation in MCF7 Breast Cancer Cells.
Breast Neoplasms
Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study.
Breast Neoplasms
Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women.
Breast Neoplasms
Circulating 27-hydroxycholesterol and breast cancer tissue expression of CYP27A1, CYP7B1, LXR-?, and ER?: results from the EPIC-Heidelberg cohort.
Breast Neoplasms
Clinical CYP2D6 Genotyping to Personalize Adjuvant Tamoxifen Treatment in ER-Positive Breast Cancer Patients: Current Status of a Controversy.
Breast Neoplasms
Clinical effects of A4889G and T6235C polymorphisms in cytochrome P-450 CYP1A1 for breast cancer patients treated with tamoxifen: implications for tumor aggressiveness and patient survival.
Breast Neoplasms
Clinical epidemiology and pharmacology of CYP2D6 inhibition related to breast cancer outcomes.
Breast Neoplasms
Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer.
Breast Neoplasms
Clinical implications of CYP2D6 genotyping in tamoxifen treatment for breast cancer.
Breast Neoplasms
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy.
Breast Neoplasms
Clinical Relevance of CYP2D6 Genetics for Tamoxifen Response in Breast Cancer.
Breast Neoplasms
Clinical significance of CYP2D6 polymorphisms and tamoxifen in women with breast cancer.
Breast Neoplasms
Clinical Trial: CYP2D6 Related Dose Escalation of Tamoxifen in Breast Cancer Patients With Iranian Ethnic Background Resulted in Increased Concentrations of Tamoxifen and Its Metabolites.
Breast Neoplasms
Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue.
Breast Neoplasms
Co-administration of rivaroxaban with drugs that share its elimination pathways: pharmacokinetic effects in healthy subjects.
Breast Neoplasms
Co-planar 3,3',4,4',5-pentachlorinated biphenyl and non-co-planar 2,2',4,6,6'-pentachlorinated biphenyl differentially induce recruitment of oestrogen receptor alpha to aryl hydrocarbon receptor target genes.
Breast Neoplasms
Cobicistat Boosts the Intestinal Absorption of Transport Substrates, Including HIV Protease Inhibitors and GS-7340, In Vitro.
Breast Neoplasms
Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status.
Breast Neoplasms
Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine.
Breast Neoplasms
Combined effect of CYP1B1 codon 432 polymorphism and N-acetyltransferase 2 slow acetylator phenotypes in relation to breast cancer in the Turkish population.
Breast Neoplasms
Combined effect of CYP1B1, COMT, GSTP1, and MnSOD genotypes and risk of postmenopausal breast cancer.
Breast Neoplasms
Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols.
Breast Neoplasms
Common genetic variants in the vitamin D pathway including genome-wide associated variants are not associated with breast cancer risk among Chinese women.
Breast Neoplasms
Comparative molecular field analysis of non-steroidal aromatase inhibitors: an extended model for two different structural classes.
Breast Neoplasms
Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines.
Breast Neoplasms
Comparative study of polymorphism frequencies of the CYP2D6, CYP3A5, CYP2C8 and IL-10 genes in Mexican and Spanish women with breast cancer.
Breast Neoplasms
Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients.
Breast Neoplasms
Comprehensive and Automated Linear Interaction Energy Based Binding-Affinity Prediction for Multifarious Cytochrome P450 Aromatase Inhibitors.
Breast Neoplasms
Comprehensive CYP2D6 genotype and adherence affect outcome in breast cancer patients treated with tamoxifen monotherapy.
Breast Neoplasms
Computational Treatment Simulations to Assess the Need for Personalized Tamoxifen Dosing in Breast Cancer Patients of Different Biogeographical Groups.
Breast Neoplasms
Concomitant use of tamoxifen and endoxifen in postmenopausal early breast cancer: prediction of plasma levels by physiologically-based pharmacokinetic modeling.
Breast Neoplasms
Concordance Between CYP2D6 Genotypes Obtained From Tumor-Derived and Germline DNA.
Breast Neoplasms
Concurrent use of tamoxifen with CYP2D6 inhibitors and the risk of breast cancer recurrence.
Breast Neoplasms
Constitutional genetic variation at the human aromatase gene (Cyp19) and breast cancer risk.
Breast Neoplasms
Constitutive regulation of CYP1B1 by the aryl hydrocarbon receptor (AhR) in pre-malignant and malignant mammary tissue.
Breast Neoplasms
Contribution of ABCB1 and CYP2D6 genotypes to the outcome of tamoxifen adjuvant treatment in premenopausal women with breast cancer.
Breast Neoplasms
Coprescription of Tamoxifen and Medications That Inhibit CYP2D6: Recommendations Based on the Proposals by the Grading of Recommendations Assessment, Development, and Evaluation Working Group.
Breast Neoplasms
Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyrene.
Breast Neoplasms
Correlation of aromatase and cyclooxygenase gene expression in human breast cancer specimens.
Breast Neoplasms
Cost-effectiveness Analysis of CYP2D6*10 Pharmacogenetic Testing to Guide the Adjuvant Endocrine Therapy for Postmenopausal Women with Estrogen Receptor Positive Early Breast Cancer in China.
Breast Neoplasms
Cross-Talk Between One-Carbon Metabolism and Xenobiotic Metabolism: Implications on Oxidative DNA Damage and Susceptibility to Breast Cancer.
Breast Neoplasms
Crosstalk between the peroxisome proliferator-activated receptor ? (PPAR?) and the vitamin D receptor (VDR) in human breast cancer cells: PPAR? binds to VDR and inhibits 1?,25-dihydroxyvitamin D(3) mediated transactivation.
Breast Neoplasms
Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives.
Breast Neoplasms
Cyclooxygenase-2 directly regulates gene expression of P450 Cyp19 aromatase promoter regions pII, pI.3 and pI.7 and estradiol production in human breast tumor cells.
Breast Neoplasms
Cyclophosphamide bioactivation pharmacogenetics in breast cancer patients.
Breast Neoplasms
CYP17 (T-34C) and CYP19 (Trp39Arg) polymorphisms and their cooperative effects on breast cancer susceptibility.
Breast Neoplasms
CYP17 (T34C), CYP19 (Trp39Arg), and FGFR2 (C906T) polymorphisms and the risk of breast cancer in south Indian women.
Breast Neoplasms
CYP19 gene polymorphisms and the susceptibility to breast cancer in Xinjiang Uigur women.
Breast Neoplasms
CYP19 genetic polymorphism haplotype AASA is associated with a poor prognosis in premenopausal women with lymph node-negative, hormone receptor-positive breast cancer.
Breast Neoplasms
CYP19A1 rs10046 pharmacogenetics in postmenopausal breast cancer patients treated with aromatase inhibitors: One-year follow-up.
Breast Neoplasms
CYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish Caucasian population.
Breast Neoplasms
CYP1A1 and GSTP1 gene variations in breast cancer: a systematic review and case-control study.
Breast Neoplasms
CYP1A1 gene polymorphisms: lack of association with breast cancer susceptibility in the southern region (Madurai) of India.
Breast Neoplasms
CYP1A1 genetic polymorphism is a promising predictor to improve chemotherapy effects in patients with metastatic breast cancer treated with docetaxel plus thiotepa vs. docetaxel plus capecitabine.
Breast Neoplasms
CYP1A1 is overexpressed upon incubation of breast cancer cells with a polyphenolic cocoa extract.
Breast Neoplasms
CYP1A1, CYP1B1, GSTM1 and GSTT1 genetic variants and breast cancer risk in Mexican women.
Breast Neoplasms
CYP1A1, GSTM1, and GSTT1 polymorphisms and breast cancer risk in Brazilian women.
Breast Neoplasms
CYP1A2 - a novel genetic marker for early aromatase inhibitor response in the treatment of breast cancer patients.
Breast Neoplasms
CYP1B1 and CYP19 gene polymorphisms and breast cancer incidence: no association in the ARIC study.
Breast Neoplasms
CYP1B1 expression is induced by docetaxel: effect on cell viability and drug resistance.
Breast Neoplasms
CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma.
Breast Neoplasms
CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKC? activation and phosphorylation of XIAP.
Breast Neoplasms
CYP27A1 expression is associated with risk of late lethal estrogen receptor-positive breast cancer in postmenopausal patients.
Breast Neoplasms
CYP2C19*2 and CYP2C19*17 variants and effect of tamoxifen on breast cancer recurrence: Analysis of the International Tamoxifen Pharmacogenomics Consortium dataset.
Breast Neoplasms
CYP2C8 and CYP2C9 polymorphisms in relation to tumour characteristics and early breast cancer related events among 652 breast cancer patients.
Breast Neoplasms
CYP2D6 and adjuvant tamoxifen: possible differences of outcome in pre- and post-menopausal patients.
Breast Neoplasms
CYP2D6 and Endoxifen in Tamoxifen Therapy: A Tribute to David A. Flockhart.
Breast Neoplasms
CYP2D6 and UGT2B7 Genotype and Risk of Recurrence in Tamoxifen-Treated Breast Cancer Patients.
Breast Neoplasms
CYP2D6 as a treatment decision aid for ER-positive non-metastatic breast cancer patients: a systematic review with accompanying clinical practice guidelines.
Breast Neoplasms
CYP2D6 gene polymorphisms in Brazilian patients with breast cancer treated with adjuvant tamoxifen and its association with disease recurrence.
Breast Neoplasms
CYP2D6 gene variants and their association with breast cancer susceptibility.
Breast Neoplasms
CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen.
Breast Neoplasms
CYP2D6 Genetic Polymorphisms and Phenotypes in Different Ethnicities of Malaysian Breast Cancer Patients.
Breast Neoplasms
CYP2D6 Genotype and Adjuvant Tamoxifen: Meta-analysis of Heterogeneous Study Populations.
Breast Neoplasms
CYP2D6 Genotype and Risk of Recurrence in Tamoxifen Treated Breast Cancer Patients.
Breast Neoplasms
CYP2D6 Genotype and Tamoxifen Response for Breast Cancer: A Systematic Review and Meta-Analysis.
Breast Neoplasms
CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women with Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial.
Breast Neoplasms
CYP2D6 genotype in relation to hot flashes as tamoxifen side effect in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial.
Breast Neoplasms
CYP2D6 genotype in relation to tamoxifen efficacy in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial.
Breast Neoplasms
CYP2D6 genotype is not associated with survival in breast cancer patients treated with tamoxifen: results from a population-based study.
Breast Neoplasms
CYP2D6 Genotype Predicts Plasma Concentrations of Tamoxifen Metabolites in Ethiopian Breast Cancer Patients.
Breast Neoplasms
CYP2D6 Genotype Predicts Tamoxifen Discontinuation and Prognosis in Patients With Breast Cancer.
Breast Neoplasms
CYP2D6 genotype should not be used for deciding about tamoxifen therapy in postmenopausal breast cancer.
Breast Neoplasms
CYP2D6 genotype should not be used to determine endocrine therapy in postmenopausal breast cancer patients.
Breast Neoplasms
CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment.
Breast Neoplasms
CYP2D6 genotype- and endoxifen-guided tamoxifen dose escalation increases endoxifen serum concentrations without increasing side effects.
Breast Neoplasms
CYP2D6 Genotype-Guided Tamoxifen Dosing in Hormone Receptor-Positive Metastatic Breast Cancer (TARGET-1): A Randomized, Open-Label, Phase II Study.
Breast Neoplasms
CYP2D6 genotypes, endoxifen levels, and disease recurrence in 224 Filipino and Vietnamese women receiving adjuvant tamoxifen for operable breast cancer.
Breast Neoplasms
CYP2D6 genotyping and tamoxifen in the treatment of postmenopausal breast cancer.
Breast Neoplasms
CYP2D6 genotyping and use of antidepressants in breast cancer patients: test development for clinical application.
Breast Neoplasms
CYP2D6 genotyping in breast cancer patients by liquid chromatography-electrospray ionization mass spectrometry.
Breast Neoplasms
CYP2D6 Inhibition and Breast Cancer Recurrence in a Population-Based Study in Denmark.
Breast Neoplasms
CYP2D6 phenotype indicative for optimized antiestrogen efficacy associates with outcome in early breast cancer patients.
Breast Neoplasms
CYP2D6 phenotype, tamoxifen, and risk of contralateral breast cancer in the WECARE Study.
Breast Neoplasms
CYP2D6 polymorphisms as predictors of outcome in breast cancer patients treated with tamoxifen: expanded polymorphism coverage improves risk stratification.
Breast Neoplasms
CYP2D6 polymorphisms influence tamoxifen treatment outcomes in breast cancer patients: a meta-analysis.
Breast Neoplasms
CYP2D6 polymorphisms influence the efficacy of adjuvant tamoxifen in Thai breast cancer patients.
Breast Neoplasms
CYP2D6 testing to predict response to tamoxifen in women with breast cancer. Pharmacogenomic.
Breast Neoplasms
CYP2D6*3 (A2549del), *4 (G1846A), *10 (C100T) and *17 (C1023T) genetic polymorphisms in Iranian breast cancer patients treated with adjuvant tamoxifen.
Breast Neoplasms
CYP2D6-inhibiting medication use and inherited CYP2D6 variation in relation to adverse breast cancer outcomes after tamoxifen therapy.
Breast Neoplasms
CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648) sensitivity in breast and colorectal cancer cells.
Breast Neoplasms
CYP3A4, CYP2C9 and CYP2B6 expression and ifosfamide turnover in breast cancer tissue microsomes.
Breast Neoplasms
CYP4Z1 - A Human Cytochrome P450 Enzyme that Might Hold the Key to Curing Breast Cancer.
Breast Neoplasms
Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review.
Breast Neoplasms
Cytochrome P-450 1B1 Leu432Val Polymorphism Does Not Show Association With Breast Cancer in Northern Iranian Women With a History of Infertility.
Breast Neoplasms
Cytochrome P-450 2D6 (CYP2D6) Genotype and Breast Cancer Recurrence in Tamoxifen-Treated Patients: Evaluating the Importance of Loss of Heterozygosity.
Breast Neoplasms
Cytochrome P1B1 (CYP1B1) polymorphisms and cancer risk: a meta-analysis of 52 studies.
Breast Neoplasms
Cytochrome P450 1 enzyme inhibition and anticancer potential of chromene amides from Amyris plumieri.
Breast Neoplasms
Cytochrome P450 1A1 (CYP1A1) Gene Polymorphisms and Susceptibility to Breast Cancer: a Meta-Analysis in the Chinese Population.
Breast Neoplasms
Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women.
Breast Neoplasms
Cytochrome P450 1A1 (CYP1A1) T3801C and A2455G polymorphisms in breast cancer risk: a meta-analysis.
Breast Neoplasms
Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study.
Breast Neoplasms
Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study.
Breast Neoplasms
Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity.
Breast Neoplasms
Cytochrome P450 1B1 and catechol-O-methyltransferase genetic polymorphisms and breast cancer risk in Chinese women: results from the shanghai breast cancer study and a meta-analysis.
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Cytochrome P450 1B1 gene polymorphisms and postmenopausal breast cancer risk.
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Cytochrome P450 1B1 promotes cancer cell survival via specificity protein 1 (Sp1)-mediated suppression of death receptor 4.
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Cytochrome P450 1B1 Val432Leu polymorphism and breast cancer risk in Nigerian women: a case control study.
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Cytochrome P450 2D6 activity predicts discontinuation of tamoxifen therapy in breast cancer patients.
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Cytochrome P450 2D6 and outcomes of adjuvant tamoxifen therapy: results of a meta-analysis.
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Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells.
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Cytochrome P450 2U1 Is a Novel Independent Prognostic Biomarker in Breast Cancer Patients.
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Cytochrome p450 and glutathione transferase expression in human breast cancer.
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Cytochrome P450 CYP1 metabolism of hydroxylated flavones and flavonols: Selective bioactivation of luteolin in breast cancer cells.
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Cytochrome P450 CYP1B1 and catechol O-methyltransferase (COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population.
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Cytochrome P450 Genetic Variation Associated with Tamoxifen Biotransformation in American Indian and Alaska Native People.
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Cytochrome p450 inhibitory properties of common efflux transporter inhibitors.
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Cytochrome P450 Polymorphisms and their Relationship with Premature Ovarian Failure in Premenopausal Women with Breast Cancer Receiving Doxorubicin and Cyclophosphamide.
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Cytochrome P4501A1 and glutathione S-transferase (M1) genetic polymorphisms and postmenopausal breast cancer risk.
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Cytochrome P4501A1 genetic polymorphisms and breast cancer risk in Nigerian women.
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Cytochrome P4501A1 polymorphism as a susceptibility factor for breast cancer in postmenopausal Chinese women in Taiwan.
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Cytotoxicity and gene expression profiles of novel synthesized steroid derivatives as chemotherapeutic anti-breast cancer agents.
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DDT exposure during pregnancy and DNA methylation alterations in female offspring in the Child Health and Development Study.
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Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes.
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Defining molecular sensors to assess long-term effects of pesticides on carcinogenesis.
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Design and Characterization of the First Selective and Potent Mechanism-Based Inhibitor of Cytochrome P450 4Z1.
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Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17?-hydroxylase-C17,20-lyase (Cyp17).
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Detection of Cytochrome P450 Polymorphisms in Breast Cancer Patients May Impact on Tamoxifen Therapy
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Determination of CYP2D6 *3, *4, and *10 frequency in women with breast cancer in São Luís, Brazil, and its association with prognostic factors and disease-free survival.
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Development of an estrogen-dependent breast cancer co-culture model as a tool for studying endocrine disruptors.
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Development, validation and clinical application of a HPLC-FL method for CYP2D6 phenotyping in South Brazilian breast cancer patients.
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Development, Verification, and Prediction of Osimertinib Drug-Drug Interactions Using PBPK Modeling Approach to Inform Drug Label.
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Dextromethorphan as a phenotyping test to predict endoxifen exposure in patients on tamoxifen treatment.
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Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase.
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Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially.
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Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.
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Dietary phenethyl isothiocyanate alters gene expression in human breast cancer cells.
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Differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible CYP1A1 expression in human breast carcinoma cell lines involve altered trans-acting factors.
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Differences in the action of lower and higher chlorinated polychlorinated naphthalene (PCN) congeners on estrogen dependent breast cancer cell line viability and apoptosis, and its correlation with Ahr and CYP1A1 expression.
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Different response of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-sensitive genes in human breast cancer MCF-7 and MDA-MB 231 cells.
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Differential action of chlorinated polycyclic aromatic hydrocarbons on aryl hydrocarbon receptor-mediated signaling in breast cancer cells.
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Differential Association of Cytochrome P450 3A4 Genotypes With Onsets of Breast Tumors in African American Versus Caucasian Patients.
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Differential effect of over-expressing UGT1A1 and CYP1A1 on xenobiotic assault in MCF-7 cells.
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Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.
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Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells.
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Differential ligand-dependent activation and a role for Y322 in aryl hydrocarbon receptor-mediated regulation of gene expression.
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Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7.
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Discovery of the Anti-Tumor Mechanism of Calycosin Against Colorectal Cancer by Using System Pharmacology Approach.
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Distinct prevalence of the CYP19 Delta3(TTTA)(7) allele in premenopausal versus postmenopausal breast cancer patients, but not in control individuals.
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Distribution of aromatase P450 transcripts and adipose fibroblasts in the human breast.
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DNA damage induced by NADPH cytochrome P450 reductase-activated idarubicin in sensitive and multidrug resistant MCF7 breast cancer cells.
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DNA microarray-based analysis of single nucleotide polymorphisms may be useful for assessing the risks and benefits of hormone therapy.
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Do single nucleotide polymorphisms in xenobiotic metabolizing genes determine breast cancer susceptibility and treatment outcomes?
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Does purified Swedish pollen extract, a nonhormonal treatment for vasomotor symptoms, inhibit the CYP2D6 enzyme system?
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Does race modify the association between CYP1B1 Val432Leu polymorphism and breast cancer risk? A critical appraisal of a recent meta-analysis.
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Don't think twice it's all right: tamoxifen and CYP2D6 genotyping in the treatment of breast cancer patients.
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Dose escalation of tamoxifen in patients with low endoxifen level: evidence for therapeutic drug monitoring - The TADE Study.
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Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients.
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Downregulation of BCRP and anti-apoptotic proteins by proadifen (SKF-525A) is responsible for the enhanced mitoxantrone accumulation and toxicity in mitoxantrone-resistant human promyelocytic leukemia cells.
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Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion.
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Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells.
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Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells.
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Drug metabolising enzyme polymorphisms and chemotherapy-related ovarian failure in young breast cancer survivors.
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Drug-Drug Interaction Study of Apixaban with Cyclosporine and Tacrolimus in Healthy Volunteers.
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Drug-metabolizing enzyme polymorphisms predict clinical outcome in a node-positive breast cancer cohort.
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Drug-related genetic polymorphisms affecting severe chemotherapy-induced neutropenia in breast cancer patients: A hospital-based observational study.
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Drugs and Scaffold That Inhibit Cytochrome P450 27A1 In Vitro and In Vivo.
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Effect of a negative regulatory element (NRE) on the human CYP1A1 gene expression in breast carcinoma MCF-7 and hepatoma HepG2 cells.
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Effect of biochanin A on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells.
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Effect of concomitant CYP2D6 inhibitor use and tamoxifen adherence on breast cancer recurrence in early-stage breast cancer.
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Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells.
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Effect of CYP19 rs6493497 and rs7176005 haplotype status on in vivo aromatase transcription, plasma and tissue estrogen levels in postmenopausal women.
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Effect of CYP2C19 and CYP2D6 genotype on tamoxifen treatment outcome indicates endogenous and exogenous interplay.
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Effect of dioxin and 17?-estradiol on the expression of cytochrome P450 1A1 gene via an estrogen receptor dependent pathway in cellular and xenografted models.
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Effect of Genetic Polymorphisms and Long-Term Tobacco Exposure on the Risk of Breast Cancer.
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Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction.
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Effect of imatinib mesilate on the disposition kinetics of ciclosporin in rats.
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Effect of transient expression of the oestrogen receptor on constitutive and inducible CYP1A1 in Hs578T human breast cancer cells.
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Effect of Upadacitinib on the Pharmacokinetics of Rosuvastatin or Atorvastatin in Healthy Subjects.
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Effects of Chrysin and Its Major Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide on Cytochrome P450 Enzymes and on OATP, P-gp, BCRP, and MRP2 Transporters.
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Effects of conditioned medium from different cultured cell types on aromatase expression in adipose stromal cells.
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Effects of cycloheximide on the induction of CYP1A1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in three human breast cancer cell lines.
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Effects of CYP2B6 genetic polymorphisms in patients receiving cyclophosphamide combination chemotherapy for breast cancer.
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Effects of CYP2D6 and CYP3A5 polymorphisms on tamoxifen and its metabolites in Thai breast cancer patients.
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Effects of CYP2D6 and UGT2B7 polymorphisms on pharmacokinetics of tamoxifen in Thai breast cancer patients.
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Effects of CYP2D6*10 polymorphism on tamoxifen pharmacokinetics in patients with breast cancer in Asia: a meta-analysis.
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Effects of morin on the pharmacokinetics of etoposide in 7,12-dimethylbenz[a]anthracene-induced mammary tumors in female Sprague-Dawley rats.
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Effects of Neonicotinoid Pesticides on Promoter-Specific Aromatase (CYP19) Expression in Hs578t Breast Cancer Cells and the Role of the VEGF Pathway.
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Effects of zearalenone on mRNA expression and activity of cytochrome P450 1A1 and 1B1 in MCF-7 cells.
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Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer.
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Elevated levels of the Steroidogenic Factor-1 are associated with over-expression of CYP19 in an Estrogen producing testicular Leydig cell tumour.
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Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778?875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha.
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Endoxifen levels and its association with CYP2D6 genotype and phenotype: evaluation of a southern Brazilian population under tamoxifen pharmacotherapy.
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Endoxifen's molecular mechanisms of action are concentration dependent and different than that of other anti-estrogens.
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Endoxifen, the active metabolite of tamoxifen, is a substrate of the efflux transporter P-glycoprotein (multidrug resistance 1).
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Environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer: a systematic review of the epidemiological evidence.
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Environmental Polychlorinated Biphenyl Exposure and Breast Cancer Risk: A Meta-Analysis of Observational Studies.
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EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange.
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ERCC1 and CYP1B1 polymorphisms as predictors of response to neoadjuvant chemotherapy in estrogen positive breast tumors.
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Erratum to: Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and ?-Catenin and Akt activation.
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Erratum to: Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis.
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Erratum to: The use of the (13)C-dextromethorphan breath test for phenotyping CYP2D6 in breast cancer patients using tamoxifen: association with CYP2D6 genotype and serum endoxifen levels.
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Estimation of tamoxifen metabolite concentrations in the blood of breast cancer patients through CYP2D6 genotype activity score.
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Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene.
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Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study.
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Estrogen receptor genotype is associated with risk of venous thromboembolism during tamoxifen therapy.
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Estrogen receptor reduces CYP1A1 induction in cultured human endometrial cells.
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Estrogen receptor subtype- and promoter-specific modulation of aryl hydrocarbon receptor-dependent transcription.
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Estrogen receptor-dependent regulation of CYP2B6 in human breast cancer cells.
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Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women.
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Estrogen-related genes and their contribution to racial differences in breast cancer risk.
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Evaluation of a real-time polymerase chain reaction method for the quantification of CYP1B1 gene expression in MCF-7 human breast carcinoma cells.
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Evaluation of association studies and a systematic review and meta-analysis of CYP1A1 T3801C and A2455G polymorphisms in breast cancer risk.
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Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk.
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Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: results from the NSABP P1 and P2 clinical trials.
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Evaluation of CYP2D6 enzyme activity using a 13C-dextromethorphan breath test in women receiving adjuvant tamoxifen.
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Evaluation of drug-drug interaction of lusutrombopag, a thrombopoietin receptor agonist, via metabolic enzymes and transporters.
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Evaluation of endometrial thickness and bone mineral density based on CYP2D6 polymorphisms in Turkish breast cancer patients receiving tamoxifen treatment.
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Evaluation of Tissue Stem Cell-Derived Human Intestinal Organoids, a Physiologically Relevant Model to Evaluate Cytochrome P450 Induction in Gut.
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Exemestane potency is unchanged by common nonsynonymous polymorphisms in CYP19A1: results of a novel anti-aromatase activity assay examining exemestane and its derivatives.
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Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in
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Expression of CYP1A1 and CYP1B1 depends on cell-specific factors in human breast cancer cell lines: role of estrogen receptor status.
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Expression of CYP1A1, CYP1B1 and MnSOD in a panel of human cancer cell lines.
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Expression of cytochrome P450 1B1 and catechol-O-methyltransferase in breast tissue and their associations with breast cancer risk.
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Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression.
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Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma.
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Expression of xenobiotic and steroid hormone metabolizing enzymes in human breast carcinomas.
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First-in-Human Phase I Study of the Tamoxifen Metabolite Z-Endoxifen in Women With Endocrine-Refractory Metastatic Breast Cancer.
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Food constituent- and herb-drug interactions in oncology: Influence of quantitative modelling on Drug labelling.
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Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis.
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Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors.
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Functional polymorphisms in xenobiotic metabolizing enzymes and their impact on the therapy of breast cancer.
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Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.
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Further characterization of a ¹³C-dextromethorphan breath test for CYP2D6 phenotyping in breast cancer patients on tamoxifen therapy.
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Gene expression and pathologic response to neoadjuvant chemotherapy in breast cancer.
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Gene expression profiles of CYP24A1 and CYP27B1 in malignant and normal breast tissues.
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Genetic and environmental determinants on tissue response to in vitro carcinogen exposure and risk of breast cancer.
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Genetic matters of CYP2D6 in breast cancer: copy number variations and nucleotide polymorphisms.
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Genetic polymorphism of estrogen metabolizing enzymes in siberian women with breast cancer.
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Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility.
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Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer.
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Genetic polymorphisms in estrogen metabolism and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians.
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Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival.
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Genetic polymorphisms in oestrogen metabolic pathway and breast cancer: a positive association with combined CYP/GST genotypes.
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Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk.
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Genetic polymorphisms in the three malaysian races effect granisetron clinical antiemetic actions in breast cancer patients receiving chemotherapy.
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Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study.
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Genetic polymorphisms of CYP2D6 10 and CYP2C19 2, 3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen.
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Genetic polymorphisms of CYP2D6 increase the risk for recurrence of breast cancer in patients receiving tamoxifen as an adjuvant therapy.
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Genetic polymorphisms of CYP2E1, GST, and NAT2 enzymes are not associated with risk of breast cancer in a sample of Lebanese women.
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Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women.
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Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer.
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Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women.
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Genetic polymorphisms of phase I metabolizing enzyme genes, their interaction with lifetime grilled and smoked meat intake, and breast cancer incidence.
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Genetic testing and pharmacogenomics: issues for determining the impact to healthcare delivery and costs.
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Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer.
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Genetic variants of the drug-metabolizing enzyme CYP2D6 in Puerto Rican psychiatry patients: a preliminary report and potential implications for breast cancer patients.
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Genetic variation in estrogen and progesterone pathway genes and breast cancer risk: an exploration of tumor subtype-specific effects.
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Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish women.
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Genetics of CYP1A1: coamplification of specific alleles by polymerase chain reaction and association with breast cancer.
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Genistein Induces Cytochrome P450 1B1 Gene Expression and Cell Proliferation in Human Breast Cancer MCF-7 Cells.
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Genomics and pharmacogenomics of breast cancer: current knowledge and trends.
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Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients.
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Genotypes of CYP2C8 and FGD4 and their association with peripheral neuropathy or early dose reduction in paclitaxel-treated breast cancer patients.
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Glaucarubulone glucoside from Castela macrophylla suppresses MCF-7 breast cancer cell growth and attenuates benzo[a]pyrene-mediated CYP1A gene induction.
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Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme.
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GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer.
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High Coffee Intake, but Not Caffeine, is Associated with Reduced Estrogen Receptor Negative and Postmenopausal Breast Cancer Risk with No Effect Modification by CYP1A2 Genotype.
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History of Aromatase: Saga of an Important Biologic Mediator and Therapeutic Target.
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Hormonal status affects plasma exposure of tamoxifen and its main metabolites in tamoxifen-treated breast cancer patients.
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Hormone-related pathways and risk of breast cancer subtypes in African American women.
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How valid is single nucleotide polymorphism (SNP) diagnosis for the individual risk assessment of breast cancer?
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Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells.
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Hyaluronic acid-modified cationic nanoparticles overcome enzyme CYP1B1-mediated breast cancer multidrug resistance.
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Identification of 3'-methoxy-4'-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells.
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Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.
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Identification of positive and negative regulatory elements of the human cytochrome P4501A2 (CYP1A2) gene.
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Immunohistochemical demonstration of the expression of CYP2E1 in human breast tumour and non-tumour tissues.
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Immunohistochemical evaluation of cytochrome P450 (CYP) and p53 in breast cancer.
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Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1.
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Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer.
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Impact of ABCB1 and CYP2D6 polymorphisms on tamoxifen treatment outcomes and adverse events in breast cancer patients.
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Impact of CYP19A1 and ESR1 variants on early-onset side effects during combined endocrine therapy in the TEXT trial.
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Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study.
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Impact of CYP2D*6 in the adjuvant treatment of breast cancer patients with tamoxifen.
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Impact of CYP2D6 polymorphisms in tamoxifen adjuvant breast cancer treatment.
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Impact of CYP2D6 polymorphisms on endoxifen concentrations and breast cancer outcomes.
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Impact of CYP2D6 polymorphisms on tamoxifen responses of women with breast cancer: a microarray-based study in Thailand.
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Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy.
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Impact of CYP2D6*4 genotype on progression free survival in tamoxifen breast cancer treatment.
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Impact of CYP2D6, CYP3A5, CYP2C9 and CYP2C19 polymorphisms on tamoxifen pharmacokinetics in Asian breast cancer patients.
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Impact of gene polymorphisms in drug-metabolizing enzymes and transporters on trough concentrations of rivaroxaban in patients with atrial fibrillation.
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Impact of the CYP2D6 phenotype on the outcome of breast cancer patients treated with tamoxifen.
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Impacts of Cytochrome P450 2D6 (CYP2D6) Genetic Polymorphism in Tamoxifen Therapy for Breast Cancer.
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Impaired tamoxifen metabolism reduces survival in familial breast cancer patients.
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Impairment of endoxifen formation in tamoxifen-treated premenopausal breast cancer patients carrying reduced-function CYP2D6 alleles.
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Implication of Xenobiotic Metabolizing Enzyme gene (CYP2E1, CYP2C19, CYP2D6, mEH and NAT2) polymorphisms in breast carcinoma.
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Importance of asparagine-381 and arginine-487 for substrate recognition in CYP4Z1.
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Improved Prediction of Endoxifen Metabolism by CYP2D6 Genotype in Breast Cancer Patients Treated with Tamoxifen.
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In situ estrogen production and its regulation in human breast carcinoma: from endocrinology to intracrinology.
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Incidence of inactive allele CYP2D6*4 among Greek women suffering from hormone-sensitive breast cancer.
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Incorporating cytochrome P450 3A4 genotype expression and FT-IR/Raman spectroscopy data as means of identification of breast tumors.
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Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer.
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Increased expression of cytochrome p450 1A1 and 1B1 genes in anti-estrogen-resistant human breast cancer cell lines.
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Increasing tamoxifen dose in breast cancer patients based on CYP2D6 genotypes and endoxifen levels: effect on active metabolite isomers and the antiestrogenic activity score.
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Individualization of tamoxifen therapy: Much more than just CYP2D6 genotyping.
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Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells.
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Indolo[3,2-b]carbazole: a dietary-derived factor that exhibits both antiestrogenic and estrogenic activity.
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Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites.
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Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite.
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Induction of cytochrome P450 1A1 in MCF-7 human breast cancer cells by 4-chlorobiphenyl (PCB3) and the effects of its hydroxylated metabolites on cellular apoptosis.
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Induction of cytochrome P450 1B1 in MDA-MB-231 human breast cancer cells by non-ortho-substituted polychlorinated biphenyls.
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Induction of cytochrome P450 2B1 in rat liver by the aromatase inhibitor aminoglutethimide.
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Induction of Human Intestinal and Hepatic Organic Anion Transporting Polypeptides: Where Is the Evidence for Its Relevance in Drug-Drug Interactions?
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Influence of CYP2D6 and CYP3A4 Phenotypes, Drug Interactions, and Vitamin D Status on Tamoxifen Biotransformation.
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Influence of CYP2D6 polymorphisms on serum levels of tamoxifen metabolites in Spanish women with breast cancer.
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Influence of CYP2D6-genotype on tamoxifen efficacy in advanced breast cancer.
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Influence of Estrogenic Metabolic Pathway Genes Polymorphisms on Postmenopausal Breast Cancer Risk.
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Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide.
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Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: a patient feasibility study.
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Inhibition of aromatase expression by a psoralen-linked triplex-forming oligonucleotide targeted to a coding sequence.
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Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol.
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Inhibition of human cytochrome p450 1b1 further clarifies its role in the activation of dibenzo[a,l]pyrene in cells in culture.
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Inhibitory effects of chrysoeriol on DNA adduct formation with benzo[a]pyrene in MCF-7 breast cancer cells.
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Integrated safety analysis of rolapitant with coadministered drugs from phase II/III trials: an assessment of CYP2D6 or BCRP inhibition by rolapitant.
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Interaction between genetic polymorphism of cytochrome P450-1B1 and environmental pollutants in breast cancer risk.
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Interaction between smoking history and gene expression levels impacts survival of breast cancer patients.
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Interaction of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferase M1 to breast cancer in Taiwanese woman without smoking and drinking habits.
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Interaction potential of the endothelin-A receptor antagonist atrasentan with drug transporters and drug-metabolising enzymes assessed in vitro.
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Interactions between genetic polymorphism of cytochrome P450-1B1, sulfotransferase 1A1, catechol-o-methyltransferase and tobacco exposure in breast cancer risk.
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Interactions between tamoxifen and antidepressants via cytochrome P450 2D6.
Breast Neoplasms
Interest and attitudes of patients, cancer physicians, medical students and cancer researchers towards a spectrum of genetic tests relevant to breast cancer patients.
Breast Neoplasms
Interindividual variation in CYP1A1 expression in breast tissue and the role of genetic polymorphism.
Breast Neoplasms
Interrelationships between cyclooxygenases and aromatase: unraveling the relevance of cyclooxygenase inhibitors in breast cancer.
Breast Neoplasms
Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies.
Breast Neoplasms
Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer.
Breast Neoplasms
Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells.
Breast Neoplasms
Is aryl hydrocarbon hydroxylase activity a new prognostic indicator for breast cancer?
Breast Neoplasms
Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk.
Breast Neoplasms
Joint effects of the CYP1A1 MspI, ERalpha PvuII, and ERalpha XbaI polymorphisms on the risk of breast cancer: results from a population-based case-control study in Shanghai, China.
Breast Neoplasms
Lack of any association between functionally significant CYP2D6 polymorphisms and clinical outcomes in early breast cancer patients receiving adjuvant tamoxifen treatment.
Breast Neoplasms
Lack of Association between CYP1A1 M2 and M4 Polymorphisms and Breast Carcinoma in Jordanian Women: a Case-Control Study.
Breast Neoplasms
Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics.
Breast Neoplasms
Lack of significant association between CYP1A1 T3801C polymorphism and breast cancer risk: a meta-analysis involving 25,087 subjects.
Breast Neoplasms
Leptin induces CYP1B1 expression in MCF-7 cells through ligand-independent activation of the ER? pathway.
Breast Neoplasms
Lessons for pharmacogenomics studies: association study between CYP2D6 genotype and tamoxifen response.
Breast Neoplasms
Letrozole : in postmenopausal hormone-responsive early-stage breast cancer.
Breast Neoplasms
Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells.
Breast Neoplasms
Letrozole concentration is associated with CYP2A6 variation but not with arthralgia in patients with breast cancer.
Breast Neoplasms
Ligands for the peroxisomal proliferator-activated receptor gamma and the retinoid X receptor inhibit aromatase cytochrome P450 (CYP19) expression mediated by promoter II in human breast adipose.
Breast Neoplasms
Limitations in Adjuvant Breast Cancer Therapy: The Predictive Potential of Pharmacogenetics and Pharmacogenomics.
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Limited predictive value of achieving beneficial plasma (Z)-endoxifen threshold level by CYP2D6 genotyping in tamoxifen-treated Polish women with breast cancer.
Breast Neoplasms
Long-term exposure of 4-hydroxyestradiol induces the cancer cell characteristics via upregulating CYP1B1 in MCF-10A cells.
Breast Neoplasms
Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.
Breast Neoplasms
Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for tamoxifen pharmacogenetic studies.
Breast Neoplasms
Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation.
Breast Neoplasms
Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.
Breast Neoplasms
Mammary-specific ablation of Cyp24a1 inhibits development, reduces proliferation and increases sensitivity to vitamin D.
Breast Neoplasms
Marked heterogeneity of aromatase activity in human malignant melanoma tissue.
Breast Neoplasms
Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice.
Breast Neoplasms
Mechanism of action of alpha-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells.
Breast Neoplasms
Mechanisms and Predictions of Drug-Drug Interactions of the Hepatitis C Virus Three Direct-Acting Antiviral Regimen: Paritaprevir/Ritonavir, Ombitasvir, and Dasabuvir.
Breast Neoplasms
Melatonin receptors, melatonin metabolizing enzymes and cyclin D1 in human breast cancer.
Breast Neoplasms
Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review.
Breast Neoplasms
Meta-analysis of genetic polymorphisms in xenobiotic metabolizing enzymes and their association with breast cancer risk.
Breast Neoplasms
Metabolic-Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib.
Breast Neoplasms
Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human cytochrome P4501B1.
Breast Neoplasms
Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.
Breast Neoplasms
Methanol extract of the ethnopharmaceutical remedy Smilax spinosa exhibits anti-neoplastic activity.
Breast Neoplasms
Methylation and its role in the disposition of tanshinol, a cardiovascular carboxylic catechol from Salvia miltiorrhiza roots (Danshen).
Breast Neoplasms
Modulating Effect of Hypnea musciformis (Red Seaweed) on Lipid Peroxidation, Antioxidants and Biotransforming Enzymes in 7,12-Dimethylbenz (a) Anthracene Induced Mammary Carcinogenesis in Experimental Animals.
Breast Neoplasms
Modulating potential of L-sulforaphane in the expression of cytochrome p450 to identify potential targets for breast cancer chemoprevention and therapy using breast cell lines.
Breast Neoplasms
Modulation of CYP1A1, CYP1A2 and CYP1B1 Expression by Cabbage Juices and Indoles in Human Breast Cell Lines.
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Molecular epidemiology of breast cancer: genetic variation in steroid hormone metabolism.
Breast Neoplasms
Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism.
Breast Neoplasms
Molecular Pathways: Adipose Inflammation as a Mediator of Obesity-Associated Cancer.
Breast Neoplasms
Molecular pharmacology of aromatase and its regulation by endogenous and exogenous agents.
Breast Neoplasms
Multi-gene and Drug Interaction Approach for Tamoxifen Metabolite Patterns Reveals Possible Involvement of CYP2C9, CYP2C19 and ABCB1.
Breast Neoplasms
Mutation and protein expression analysis of CYP1A1 gene-a study on female breast cancer cases from India.
Breast Neoplasms
NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1.
Breast Neoplasms
Napabucasin Drug-Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers.
Breast Neoplasms
No association between a single nucleotide polymorphism in CYP19 and breast cancer risk.
Breast Neoplasms
No association between CYP1B1 Val432Leu polymorphism and breast cancer risk: a meta-analysis involving 40,303 subjects.
Breast Neoplasms
No association between CYP2D6*10 genotype and survival of node-negative Japanese breast cancer patients receiving adjuvant tamoxifen treatment.
Breast Neoplasms
No association found between CYP2D6 genotype and early breast cancer events in tamoxifen-treated patients.
Breast Neoplasms
No associations between aromatase gene polymorphisms and breast cancer risk in Saudi patients.
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No increase in breast cancer recurrence with concurrent use of tamoxifen and some CYP2D6-inhibiting medications.
Breast Neoplasms
Nobiletin bioactivation in MDA-MB-468 breast cancer cells by cytochrome P450 CYP1 enzymes.
Breast Neoplasms
Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice.
Breast Neoplasms
Obatoclax as a perpetrator in drug-drug interactions and its efficacy in multidrug resistance cell lines.
Breast Neoplasms
Oroxylin A, a methylated metabolite of baicalein, exhibits a stronger inhibitory effect than baicalein on the CYP1B1-mediated carcinogenic estradiol metabolite formation.
Breast Neoplasms
Overexpression of G6PD is associated with high risks of recurrent metastasis and poor progression-free survival in primary breast carcinoma.
Breast Neoplasms
Paclitaxel Nanoparticles Induce Apoptosis and Regulate TXR1, CYP3A4 and CYP2C8 in Breast Cancer and Hepatoma Cells.
Breast Neoplasms
Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese.
Breast Neoplasms
Pairwise combinations of estrogen metabolism genotypes in postmenopausal breast cancer etiology.
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Pathological characteristics, survival, and risk of breast cancer associated with estrogen and xenobiotic metabolism polymorphisms in Mexican women with breast cancer.
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Patients' understanding of how genotype variation affects benefits of tamoxifen therapy for breast cancer.
Breast Neoplasms
Pazopanib: the newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma.
Breast Neoplasms
Peroxisome proliferator-activated receptor ? (PPAR?)-cytochrome P450 epoxygenases-soluble epoxide hydrolase axis in ER?+?PR?+?HER2- breast cancer.
Breast Neoplasms
Personalized medicine in breast cancer: tamoxifen, endoxifen, and CYP2D6 in clinical practice.
Breast Neoplasms
Pharmacogenetic analysis of paclitaxel transport and metabolism genes in breast cancer.
Breast Neoplasms
Pharmacogenetic testing in the face of unclear clinical efficacy: Lessons from cytochrome P450 2D6 for tamoxifen.
Breast Neoplasms
Pharmacogenetics and breast cancer endocrine therapy: CYP2D6 as a predictive factor for tamoxifen metabolism and drug response?
Breast Neoplasms
Pharmacogenetics in breast cancer: steps toward personalized medicine in breast cancer management.
Breast Neoplasms
Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Breast Neoplasms
Pharmacogenetics of aromatase inhibitors in endocrine responsive breast cancer: lessons learnt from tamoxifen and CYP2D6 genotyping.
Breast Neoplasms
Pharmacogenetics of solid tumors: directed therapy in breast, lung, and colorectal cancer: a paper from the 2008 william beaumont hospital symposium on molecular pathology.
Breast Neoplasms
Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes.
Breast Neoplasms
Pharmacogenomic variation of CYP2D6 and the choice of optimal adjuvant endocrine therapy for postmenopausal breast cancer: a modeling analysis.
Breast Neoplasms
Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects.
Breast Neoplasms
Pharmacogenomics of tamoxifen: roles of drug metabolizing enzymes and transporters.
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Pharmacogenomics, CYP2D6, and Tamoxifen: A Survey of the Reasons Sustaining European Clinical Practice Paradigms.
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Pharmacokinetic drug interactions between ondansetron and tamoxifen in female Sprague-Dawley rats with DMBA-induced mammary tumor.
Breast Neoplasms
Pharmacokinetic Drug-Drug Interaction of Apalutamide, Part 1: Clinical Studies in Healthy Men and Patients with Castration-Resistant Prostate Cancer.
Breast Neoplasms
Pharmacokinetic interaction profile of riociguat, a new soluble guanylate cyclase stimulator, in vitro.
Breast Neoplasms
Pharmacokinetic properties of wogonin and its herb-drug interactions with docetaxel in rats with mammary tumors.
Breast Neoplasms
Pharmacokinetics of cyclophosphamide enantiomers in patients with breast cancer.
Breast Neoplasms
Pharmacokinetics of endoxifen and tamoxifen in female mice: implications for comparative in vivo activity studies.
Breast Neoplasms
Pharmacological relevance of endoxifen in a laboratory simulation of breast cancer in postmenopausal patients.
Breast Neoplasms
Pharmacophore modeling and in silico screening for new P450 19 (aromatase) inhibitors.
Breast Neoplasms
Physiologically Based Pharmacokinetic Modeling of Tamoxifen and its Metabolites in Women of Different CYP2D6 Phenotypes Provides New Insight into the Tamoxifen Mass Balance.
Breast Neoplasms
Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age.
Breast Neoplasms
Plasma membrane localization of CYP4Z1 and CYP19A1 and the detection of anti-CYP19A1 autoantibodies in humans.
Breast Neoplasms
Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study.
Breast Neoplasms
Polychlorinated biphenyls, cytochrome P450 1A1, and breast cancer risk in the Nurses' Health Study.
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Polychlorinated biphenyls, cytochrome P4501A1 polymorphism, and postmenopausal breast cancer risk.
Breast Neoplasms
Polymorphism in xenobiotic and estrogen metabolizing genes, exposure to perfluorinated compounds and subsequent breast cancer risk: A nested case-control study in the Danish National Birth Cohort.
Breast Neoplasms
Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II.
Breast Neoplasms
Polymorphism of the CYP2D6 gene in women with breast cancer treated with tamoxifen.
Breast Neoplasms
Polymorphism of the cytochrome P-450 1A1 (A2455G) in women with breast cancer in Eastern Azerbaijan, Iran.
Breast Neoplasms
Polymorphism of Xenobiotic-Metabolizing Genes and Breast Cancer Susceptibility in North Indian Women.
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Polymorphisms associated with circulating sex hormone levels in postmenopausal women.
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Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese women.
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Polymorphisms in CYP1A1 and smoking: no association with breast cancer risk.
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Polymorphisms in CYP1B1, GSTM1, GSTT1 and GSTP1, and susceptibility to breast cancer.
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Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients.
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Polymorphisms in drug metabolism genes, smoking, and p53 mutations in breast cancer.
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Polymorphisms in estrogen biosynthesis and metabolism-related genes, ionizing radiation exposure, and risk of breast cancer among US radiologic technologists.
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Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease.
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Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.
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Polymorphisms in Phase I (CYP450) Genes CYP1A1 (rs4646421), CYP1B1 (rs1056836), CYP19A1 (rs749292) and CYP2C8 (rs1058930) and Their Relation to Risk of Breast Cancer: A Case-Control Study in Mazandaran Province in North of Iran.
Breast Neoplasms
Polymorphisms in the human aromatase cytochrome P450 gene (CYP19) and breast cancer risk.
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Polymorphisms in Xenobiotic Metabolizing Genes, Intakes of Heterocyclic Amines and Red Meat, and Postmenopausal Breast Cancer.
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Polymorphisms of catechol estrogens metabolism pathway genes and breast cancer risk in Mexican women.
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Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer.
Breast Neoplasms
Polymorphisms of estrogen synthesizing and metabolizing genes and breast cancer risk in Japanese women.
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Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study.
Breast Neoplasms
Population-based case-control study of AhR (aryl hydrocarbon receptor) and CYP1A2 polymorphisms and breast cancer risk.
Breast Neoplasms
Possible difference in frequencies of genetic polymorphisms of estrogen receptor alpha, estrogen metabolism and P53 genes between estrogen receptor-positive and -negative breast cancers.
Breast Neoplasms
Possible Risk Modification by Polymorphisms of Estrogen Metabolizing Genes in Familial Breast Cancer Susceptibility in an Indian Population.
Breast Neoplasms
Potent CYP2D6 Inhibiting drugs do not increase relapse rate in early breast cancer patients treated with adjuvant tamoxifen.
Breast Neoplasms
Potential Benefits of Pre-emptive PGx Testing in Male Breast Cancer Patients.
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Potential differences in breast cancer risk factors based on CYP1A1 MspI and African-American-specific genotypes.
Breast Neoplasms
Potentiation of CYP1A1 gene expression in MCF-7 human breast cancer cells cotreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 12-O-tetradecanoylphorbol-13-acetate.
Breast Neoplasms
Predicting steady-state endoxifen plasma concentrations in breast cancer patients by CYP2D6 genotyping or phenotyping. Which approach is more reliable?
Breast Neoplasms
Prediction of tamoxifen outcome by genetic variation of CYP2D6 in postmenopausal women with early breast cancer.
Breast Neoplasms
Predictive pharmacogenetic biomarkers for breast cancer recurrence prevention by simvastatin.
Breast Neoplasms
Preferential induction of CYP1A1 over CYP1B1 in human breast cancer MCF-7 cells after exposure to berberine.
Breast Neoplasms
Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin.
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Prevalence of CYP2D6*2, CYP2D6*4, CYP2D6*10, and CYP3A5*3 in Thai breast cancer patients undergoing tamoxifen treatment.
Breast Neoplasms
Prevalence of the co-prescription of tamoxifen and CYP2D6 inhibitors in Saudi population: A cross sectional study.
Breast Neoplasms
Prevalent breast cancer patients with a homozygous mutant status for CYP2D6*4: response and biomarkers in tamoxifen users.
Breast Neoplasms
Preventive medical services not covered by public health insurance at Daiko Medical Center in Japan, 2004-2011.
Breast Neoplasms
Primary breast tumor levels of suspected molecular determinants of cellular sensitivity to cyclophosphamide, ifosfamide, and certain other anticancer agents as predictors of paired metastatic tumor levels of these determinants. Rational individualization of cancer chemotherapeutic regimens.
Breast Neoplasms
Prioritizing pharmacogenetic research: a value of information analysis of CYP2D6 testing to guide breast cancer treatment.
Breast Neoplasms
Profound reduction in tamoxifen active metabolite endoxifen in a breast cancer patient treated with rifampin prior to initiation of an anti-TNF? biologic for ulcerative colitis: a case report.
Breast Neoplasms
Prognostic value of using glucosylceramide synthase and cytochrome P450 family 1 subfamily A1 expression levels for patients with triple-negative breast cancer following neoadjuvant chemotherapy.
Breast Neoplasms
Prostaglandin E2 induces CYP1B1 expression via ligand-independent activation of the ERalpha pathway in human breast cancer cells.
Breast Neoplasms
Protein kinase A-dependent synergism between GATA factors and the nuclear receptor, liver receptor homolog-1, regulates human aromatase (CYP19) PII promoter activity in breast cancer cells.
Breast Neoplasms
Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment.
Breast Neoplasms
Racial differences in drug metabolism: an explanation for higher breast cancer mortality in blacks?
Breast Neoplasms
Rapid point-of-care breath test for biomarkers of breast cancer and abnormal mammograms.
Breast Neoplasms
RE Damkier: CYP2D6 genotyping and tamoxifen in the treatment of postmenopausal breast cancer.
Breast Neoplasms
Re: CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women With Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial and Re: CYP2D6 and UGT2B7 Genotype and Risk of Recurrence in Tamoxifen-Treated Breast Cancer Patients.
Breast Neoplasms
Re: CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women With Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial.
Breast Neoplasms
Re: Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.
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Re: Pharmacogenomic variation of CYP2D6 and the choice of optimal adjuvant endocrine therapy for postmenopausal breast cancer: a modeling analysis.
Breast Neoplasms
Reactivation of Estrogen Receptor ? by Vorinostat Sensitizes Mesenchymal-Like Triple-Negative Breast Cancer to Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor.
Breast Neoplasms
Real-time reverse transcription PCR assay of CYP19 expression: application to a well-defined series of post-menopausal breast carcinomas.
Breast Neoplasms
Recombinant antibody piezoimmunosensors for the detection of cytochrome P450 1B1.
Breast Neoplasms
Recruitment of monocytes and epigenetic silencing of intratumoral CYP7B1 primarily contribute to the accumulation of 27-hydroxycholesterol in breast cancer.
Breast Neoplasms
Red Clover Aryl Hydrocarbon Receptor (AhR) and Estrogen Receptor (ER) Agonists Enhance Genotoxic Estrogen Metabolism.
Breast Neoplasms
Reductive amination-assisted quantitation of tamoxifen and its metabolites by liquid phase chromatography tandem mass spectrometry.
Breast Neoplasms
Regioselective hydroxylation of steroid hormones by human cytochromes P450.
Breast Neoplasms
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.
Breast Neoplasms
Regulation of cytochrome P450 gene expression in human colon and breast tumour xenografts.
Breast Neoplasms
Relation between cytochrome P450IA1 expression and estrogen receptor content of human breast cancer cells.
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Relationship between aromatase and cyclooxygenases in breast cancer: potential for new therapeutic approaches.
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Relationship between CYP1A1 polymorphisms and invasion and metastasis of breast cancer.
Breast Neoplasms
Relationship between genotypes Sult1a2 and Cyp2d6 and tamoxifen metabolism in breast cancer patients.
Breast Neoplasms
Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma.
Breast Neoplasms
Relationship of CYP2D6 (debrisoquine hydroxylase) genotype to breast cancer susceptibility.
Breast Neoplasms
Relationships between CYP2D6 phenotype, breast cancer and hot flushes in women at high risk of breast cancer receiving prophylactic tamoxifen: results from the IBIS-I trial.
Breast Neoplasms
Relative imbalances in the expression of catechol-O-methyltransferase and cytochrome P450 in breast cancer tissue and their association with breast carcinoma.
Breast Neoplasms
Representation of CYP3A4, CYP3A5 and UGT1A4 Polymorphisms within Croatian Breast Cancer Patients' Population.
Breast Neoplasms
Resonance Raman Spectroscopy of the Oxygenated Intermediates of Human CYP19A1 Implicates a Compound I Intermediate in the Final Lyase Step.
Breast Neoplasms
Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor.
Breast Neoplasms
Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the Aryl Hydrocarbon Receptor complex and RNA Polymerase II to the regulatory regions of the corresponding genes.
Breast Neoplasms
Role and pharmacologic significance of cytochrome P-450 2D6 in oxidative metabolism of toremifene and tamoxifen.
Breast Neoplasms
Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development.
Breast Neoplasms
Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells.
Breast Neoplasms
Role of CYP2D6 testing in selection of endocrine therapy for breast cancer.
Breast Neoplasms
Role of CYP2E1 polymorphisms in breast cancer: a systematic review and meta-analysis.
Breast Neoplasms
Role of cytochrome P450 genes in breast cancer etiology and treatment: effects on estrogen biosynthesis, metabolism, and response to endocrine therapy.
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Role of estradiol metabolism and CYP1A1 polymorphisms in breast cancer risk.
Breast Neoplasms
Role of Genetic Variation in Cytochromes P450 in Breast Cancer Prognosis and Therapy Response.
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Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers.
Breast Neoplasms
Role of pharmacogenetics on adjuvant chemotherapy-induced neutropenia in Chinese breast cancer patients.
Breast Neoplasms
Role of Polymorphisms of FAM13A, PHLDB1, and CYP24A1 in Breast Cancer Risk.
Breast Neoplasms
Role of the CYP3A4-mediated 11,12-epoxyeicosatrienoic acid pathway in the development of tamoxifen-resistant breast cancer.
Breast Neoplasms
Role of the progesterone receptor (PR) in the regulation of inflammatory response pathways and aromatase in the breast.
Breast Neoplasms
Role of xenobiotic metabolizing gene polymorphisms in breast cancer susceptibility and treatment outcome.
Breast Neoplasms
Roles of coactivator proteins in dioxin induction of CYP1A1 and CYP1B1 in human breast cancer cells.
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RRM1, TUBB3, TOP2A, CYP19A1, CYP2D6: Difference between mRNA and protein expression in predicting prognosis of breast cancer patients.
Breast Neoplasms
S2R(Pgrmc1): the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling.
Breast Neoplasms
Selective Dual Inhibitors of CYP19 and CYP11B2: Targeting Cardiovascular Diseases Hiding in the Shadow of Breast Cancer.
Breast Neoplasms
Self-packed core shell nano liquid chromatography columns and silica-based monolithic trap columns for targeted proteomics.
Breast Neoplasms
Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.
Breast Neoplasms
Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients.
Breast Neoplasms
Serum concentrations of tamoxifen and its metabolites increase with age during steady-state treatment.
Breast Neoplasms
Serum polychlorinated biphenyls, cytochrome P-450 1A1 polymorphisms, and risk of breast cancer in Connecticut women.
Breast Neoplasms
Shu-Gan-Liang-Xue Decoction Simultaneously Down-regulates Expressions of Aromatase and Steroid Sulfatase in Estrogen Receptor Positive Breast Cancer Cells.
Breast Neoplasms
Side effects after docetaxel treatment in Taiwanese breast cancer patients with CYP3A4, CYP3A5, and ABCB1 gene polymorphisms.
Breast Neoplasms
Side effects associated with ultrarapid cytochrome P450 2D6 genotype among women with early stage breast cancer treated with tamoxifen.
Breast Neoplasms
Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells.
Breast Neoplasms
Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients.
Breast Neoplasms
Simple tandem repeat (TTTA)n polymorphism in CYP19 (aromatase) gene and breast cancer risk in Nigerian women.
Breast Neoplasms
Simulation with cells in vitro of tamoxifen treatment in premenopausal breast cancer patients with different CYP2D6 genotypes.
Breast Neoplasms
Single-nucleotide polymorphisms and mRNA expression of CYP1B1 influence treatment response in triple negative breast cancer patients undergoing chemotherapy.
Breast Neoplasms
Soy Isoflavones, CYP1A1, CYP1B1, and COMT Polymorphisms, and Breast Cancer: A Case-Control Study in Southwestern China.
Breast Neoplasms
ssociation of Cytochrome P450-1B1 Gene Polymorphisms with Risk of Breast Cancer: an Egyptian Study.
Breast Neoplasms
Steroid metabolism gene polymorphisms and their implications on breast and ovarian cancer prognosis.
Breast Neoplasms
Steroidogenic effect of Erxian decoction for relieving menopause via the p-Akt/PKB pathway in vitro and in vivo.
Breast Neoplasms
Structure of an activity suppressing Fab fragment to cytochrome P450 aromatase: insights into the antibody-antigen interactions.
Breast Neoplasms
Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor.
Breast Neoplasms
Studies on CYP1A1, CYP1B1 and CYP3A4 gene polymorphisms in breast cancer patients.
Breast Neoplasms
Studies on the relationship between estrogen receptor content, glutathione S-transferase pi expression, and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells.
Breast Neoplasms
Study of the frequencies of CYP1A1 gene polymorphisms and glutathione S-transferase mu1 gene in primary breast cancers: an update with an additional 114 cases.
Breast Neoplasms
Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists.
Breast Neoplasms
Sunitinib, a tyrosine kinase inhibitor, induces cytochrome P450 1A1 gene in human breast cancer MCF7 cells through ligand-independent aryl hydrocarbon receptor activation.
Breast Neoplasms
Sunlight, polymorphisms of vitamin D-related genes and risk of breast cancer.
Breast Neoplasms
Synergistic activity of polynuclear aromatic hydrocarbon mixtures as aryl hydrocarbon (Ah) receptor agonists.
Breast Neoplasms
Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones.
Breast Neoplasms
Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone.
Breast Neoplasms
Synthesis, Aromatase Inhibitory, Antiproliferative and Molecular Modeling Studies of Functionally Diverse D-Ring Pregnenolone Pyrazoles.
Breast Neoplasms
Synthesis, structure elucidation, and biochemical evaluation of 7 alpha- and 7 beta-arylaliphatic-substituted androst-4-ene-3,17-diones as inhibitors of aromatase.
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Tailoring adjuvant endocrine therapy for postmenopausal breast cancer: a CYP2D6 multiple-genotype-based modeling analysis and validation.
Breast Neoplasms
Tamoxifen Benefits and CYP2D6 Testing in Women With Hormone Receptor-Positive Breast Cancer.
Breast Neoplasms
Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients.
Breast Neoplasms
Tamoxifen metabolism in breast cancer treatment: Taking the focus off the CYP2D6 gene.
Breast Neoplasms
Tamoxifen Metabolite Concentrations, CYP2D6 Genotype, and Breast Cancer Outcomes.
Breast Neoplasms
Tamoxifen Pharmacogenetics and Metabolism: Results From the Prospective CYPTAM Study.
Breast Neoplasms
Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response.
Breast Neoplasms
Targeted Multiplex Imaging Mass Spectrometry with Single Chain Fragment Variable (scfv) Recombinant Antibodies.
Breast Neoplasms
Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potential.
Breast Neoplasms
Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development.
Breast Neoplasms
Tetra-methoxystilbene modulates ductal growth of the developing murine mammary gland.
Breast Neoplasms
The androgen metabolite 5alpha-androstane-3beta,17beta-diol (3betaAdiol) induces breast cancer growth via estrogen receptor: implications for aromatase inhibitor resistance.
Breast Neoplasms
The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer.
Breast Neoplasms
The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1.
Breast Neoplasms
The association between genetic polymorphisms in CYP19 and breast cancer risk in Korean women.
Breast Neoplasms
The association between genetic variants in the genes for cytochrome P450 B1 and ATP-binding cassette transporter genes and breast cancer risk.
Breast Neoplasms
The association of CYP2D6 *10 polymorphism with breast cancer risk and clinico-pathologic characteristics in Chinese women.
Breast Neoplasms
The associations of genetic polymorphisms in CYP1A2 and CYP3A4 with clinical outcomes of breast cancer patients in northern China.
Breast Neoplasms
The clinical effectiveness and cost-effectiveness of genotyping for CYP2D6 for the management of women with breast cancer treated with tamoxifen: a systematic review.
Breast Neoplasms
The CYP17 and CYP19 gene single nucleotide polymorphism in women with sporadic breast cancer.
Breast Neoplasms
The CYP19 gene codon 39 Trp/Arg polymorphism increases breast cancer risk in subsets of premenopausal Japanese.
Breast Neoplasms
The CYP19 RS4646 polymorphism IS related to the prognosis of stage I-II and operable stage III breast cancer.
Breast Neoplasms
The CYP19 TTTA repeat polymorphism is related to the prognosis of premenopausal stage I-II and operable stage III breast cancers.
Breast Neoplasms
The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers.
Breast Neoplasms
The CYP1B1_1358_GG genotype is associated with estrogen receptor-negative breast cancer.
Breast Neoplasms
The CYP2D6*4 polymorphism affects breast cancer survival in tamoxifen users.
Breast Neoplasms
The detoxification responses, damage effects and bioaccumulation in the scallop Chlamys farreri exposed to single and mixtures of benzo[a]pyrene and chrysene.
Breast Neoplasms
The direct proliferative stimulus of dehydroepiandrosterone on MCF7 breast cancer cells is potentiated by overexpression of aromatase.
Breast Neoplasms
The Discriminatory Value of CYP2D6 Genotyping in Predicting the Dextromethorphan/Dextrorphan Phenotype in Women with Breast Cancer.
Breast Neoplasms
The effect analysis of CYP2D6 gene polymorphism in the toremifene and tamoxifen treatment in patient with breast cancer.
Breast Neoplasms
The effect of hydroxyurea on P-glycoprotein/BCRP-mediated transport and CYP3A metabolism of imatinib mesylate.
Breast Neoplasms
The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cells.
Breast Neoplasms
The Effects of Sex Protein Receptors and Sex Steroid Hormone Gene Polymorphisms on Breast Cancer Risk.
Breast Neoplasms
The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue.
Breast Neoplasms
The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor.
Breast Neoplasms
The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-?B-driven tumour intravasation.
Breast Neoplasms
The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters.
Breast Neoplasms
The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene.
Breast Neoplasms
The impact of CYP2D6-predicted phenotype on tamoxifen treatment outcome in patients with metastatic breast cancer.
Breast Neoplasms
The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen.
Breast Neoplasms
The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.
Breast Neoplasms
The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)-Endoxifen in Breast Cancer.
Breast Neoplasms
The phospholipidosis-lnducing potential of the chemopotentiating drug, N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE, tesmilifene) correlates with its stimulation of phosphatidylserine synthesis and exposure on the plasma membrane in MCF-7 breast cancer cells.
Breast Neoplasms
The prognostic values of CYP2B6 genetic polymorphisms and metastatic sites for advanced breast cancer patients treated with docetaxel and thiotepa.
Breast Neoplasms
The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression.
Breast Neoplasms
The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells.
Breast Neoplasms
The redox protein thioredoxin-1 regulates the constitutive and inducible expression of the estrogen metabolizing cytochromes P450 1B1 and 1A1 in MCF-7 human breast cancer cells.
Breast Neoplasms
The relationship between the CYP2D6 polymorphisms and tamoxifen efficacy in adjuvant endocrine therapy of breast cancer patients in Chinese Han population.
Breast Neoplasms
The Risk of Recurrence in Breast Cancer Patients Treated with Tamoxifen: Polymorphisms of CYP2D6 and ABCB1.
Breast Neoplasms
The role of aromatase and 17-beta-hydroxysteroid dehydrogenase type 1 mRNA expression in predicting the clinical outcome of human breast cancer.
Breast Neoplasms
The Role of CYP2D6 Polymorphisms in Determining Response to Tamoxifen in Metastatic Breast Cancer Patients: Review and Egyptian Experience.
Breast Neoplasms
The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.
Breast Neoplasms
The role of pregnane x receptor in 2-acetylaminofluorene-mediated induction of drug transport and -metabolizing enzymes in mice.
Breast Neoplasms
The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells.
Breast Neoplasms
The synergistic effect between adult weight changes and CYP24A1 polymorphisms is associated with pre- and postmenopausal breast cancer risk.
Breast Neoplasms
The synthesis of 4,6-diaryl-2-pyridones and their bioactivation in CYP1 expressing breast cancer cells.
Breast Neoplasms
The synthesis of chalcones as anticancer prodrugs and their bioactivation in CYP1 expressing breast cancer cells.
Breast Neoplasms
The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells.
Breast Neoplasms
The use of the (13)C-dextromethorphan breath test for phenotyping CYP2D6 in breast cancer patients using tamoxifen: association with CYP2D6 genotype and serum endoxifen levels.
Breast Neoplasms
Therapeutic Drug Monitoring of endoxifen as an alternative for CYP2D6 genotyping in individualizing tamoxifen therapy.
Breast Neoplasms
Three polymorphisms in cytochrome P450 1B1 (CYP1B1) gene and breast cancer risk: a meta-analysis.
Breast Neoplasms
Three-dimensional quantitative structure-activity relationships of steroid aromatase inhibitors.
Breast Neoplasms
Time and dose-dependent modulation of phase 1 and phase 2 gene expression in response to treatment of MCF-7 cells with a natural anti-cancer agent.
Breast Neoplasms
Toremifene, rather than tamoxifen, might be a better option for the adjuvant endocrine therapy in CYP2D6*10T/T genotype breast cancer patients in China.
Breast Neoplasms
Toward predicting CYP2D6-mediated variable drug response from CYP2D6 gene sequencing data.
Breast Neoplasms
Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogen-activating human cytochrome P450 1B1.
Breast Neoplasms
Transcriptional activation of the porcine P450 11A insulin-like growth factor response element in MCF-7 breast cancer cells.
Breast Neoplasms
Transcriptional control of human cytochrome P1-450 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human tissue culture cell lines.
Breast Neoplasms
Transcriptomic analysis of an in vitro murine model of ovarian carcinoma: Functional similarity to the human disease and identification of prospective tumoral markers and targets.
Breast Neoplasms
Transient induction of cytochromes P450 1A1 and 1B1 in MCF-7 human breast cancer cells by indirubin.
Breast Neoplasms
Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer.
Breast Neoplasms
Trends in co-prescribing of antidepressants and tamoxifen among women with breast cancer, 2004-2010.
Breast Neoplasms
Trichostatin A down-regulates CYP19 transcript and protein levels in MCF-7 breast cancer cells.
Breast Neoplasms
Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and genetic polymorphisms in breast cancer patients.
Breast Neoplasms
Urinary bisphenol A and its interaction with CYP17A1 rs743572 are associated with breast cancer risk.
Breast Neoplasms
Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients.
Breast Neoplasms
Usefulness of novobiocin as a selective inhibitor of intestinal breast cancer resistance protein (Bcrp) in rats.
Breast Neoplasms
Utility of a novel Oatp1b2 knockout mouse model for evaluating the role of Oatp1b2 in the hepatic uptake of model compounds.
Breast Neoplasms
Validation of a microdose probe drug cocktail for clinical drug interaction assessments for drug transporters and CYP3A.
Breast Neoplasms
Validation of real-time RT-PCR for analysis of human breast cancer cell lines resistant or sensitive to treatment with antiestrogens.
Breast Neoplasms
Variants in estrogen metabolism and biosynthesis genes and urinary estrogen metabolites in women with a family history of breast cancer.
Breast Neoplasms
Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study.
Breast Neoplasms
Variants of estrogen-related genes and breast cancer risk in European and African American women.
Breast Neoplasms
Vitamin D receptor (VDR) and metabolizing enzymes CYP27B1 and CYP24A1 in breast cancer.
Breast Neoplasms
Vitamin D Receptor Activation Enhances Benzo[a]pyrene Metabolism via CYP1A1 Expression in Macrophages.
Breast Neoplasms
Vitamin D supplementation decreases serum 27-hydroxycholesterol in a pilot breast cancer trial.
Breast Neoplasms
Whole genome amplification of DNA for genotyping pharmacogenetics candidate genes.
Breast Neoplasms
WY-14643 Regulates CYP1B1 Expression through Peroxisome Proliferator-Activated Receptor ?-Mediated Signaling in Human Breast Cancer Cells.
Breast Neoplasms
Xenobiotic metabolizing and antioxidant enzymes in normal and neoplastic human breast tissue.
Breast Neoplasms
Xenobiotic-metabolising enzymes in patients with adenocarcinoma of the breast: Correlation with clinical stage and menopausal status.
Breast Neoplasms
Zinc finger nuclease-mediated knockout of AHR or ARNT in human breast cancer cells abolishes basal and ligand-dependent regulation of CYP1B1 and differentially affects estrogen receptor ? transactivation.
Breast Neoplasms
[Antagonism of tamoxifen and antidepressants among women with breast cancer].
Breast Neoplasms
[Aromatase gene expression and its modifying factors in breast tumor tissue]
Breast Neoplasms
[Association of polymorphism of genetic markers of CYP19 and CYP17 with sporadic breast cancer]
Breast Neoplasms
[CYP2D6 polymorphisms and tamoxifen: therapeutic perspectives in the management of hormonodependent breast cancer patients]
Breast Neoplasms
[Genetic polymorphism and variability of steroid hormone metabolism: connection with risk of developing breast neoplasms]
Breast Neoplasms
[Genetic polymorphism of steroidogenic enzymes and steroid receptor level in tumors of the reproductive system]
Breast Neoplasms
[Growth inhibition and multidrug resistance-reversing effect of tanshinone I A on human breast cancer cell with estrogen receptor negative]
Breast Neoplasms
[Relationship between estrogen-biosynthesis gene (CYP17, CYP19, HSD17beta1) polymorphisms and breast cancer]
Breast Neoplasms
[Study of cytochrome P450 1A1 gene 3'-UTR 6235T-C polymorphism and susceptibility to breast cancer with Uighur medicine].
Breast Neoplasms
[Study on serum organochlorines pesticides (DDTs) level, CYP1A1 genetic polymorphism and risk of breast cancer: a case control study]
Breast Neoplasms
[Study on the association between CYP24A1 genetic polymorphisms and risks related to postmenopausal breast cancer].
Breast Neoplasms
[Study on the relationship between polymorphisms of genes (CYP17, CYP19 and SULT1A1) and susceptibility to breast cancer in Chinese women]
Breast Neoplasms
[The drug-drug interaction mediated by efflux transporters and CYP450 enzymes].
Breast Neoplasms
[The polymorphism of genes of synthesis and metabolism of estrogens and the risk of breast cancer].
Breast Neoplasms, Male
A polymorphic tetranucleotide repeat in the CYP19 gene and male breast cancer.
Breast Neoplasms, Male
Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk.
Bronchitis
[Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases]
Bronchitis, Chronic
Clinical features of chronic bronchitis and genetic risk factors for the development of chronic obstructive pulmonary disease in adolescent smokers.
Bronchitis, Chronic
Genetic polymorphisms in the cytochromes P-450 (1A1, 2E1), microsomal epoxide hydrolase and glutathione S-transferase M1, T1, and P1 genes, and their relationship with chronic bronchitis and relapsing pneumonia in children.
Bronchitis, Chronic
Lack of relation between genetic polymorphism of cytochrome P-450IID6 and sporadic idiopathic Parkinson's disease.
Bronchitis, Chronic
The relationship of host factors to the pathogenesis of chronic bronchitis and obstructive airway disease: lymphoblast aryl hydrocarbon hydroxylase.
Bronchopulmonary Dysplasia
GSTP1 and CYP2B6 Genetic Polymorphisms and the Risk of Bronchopulmonary Dysplasia in Preterm Neonates.
Bronchopulmonary Dysplasia
Newborn mice lacking the gene for Cyp1a1 are more susceptible to oxygen-mediated lung injury, and are rescued by postnatal ?-napthoflavone (BNF) administration: Implications for bronchopulmonary dysplasia (BPD) in premature infants.
Budd-Chiari Syndrome
Mutations in CYP2C9 and/or VKORC1 haplotype are associated with higher bleeding complications in patients with Budd-Chiari syndrome on warfarin.
Callosities
[Study on the relationship between familial clustering of hepatocellular carcinoma and polymorphism of cytochrome P450 2E1 gene in Zhuang population, Guangxi]
Candidiasis
[Experimental study and clinical application of rapid diagnosis of systemic candida albicans infection in burns by polymerase chain reaction]
Carcinogenesis
(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent.
Carcinogenesis
12-O-tetradecanoylphorbol-13-acetate upregulates the Ah receptor and differentially alters CYP1B1 and CYP1A1 expression in MCF-7 breast cancer cells.
Carcinogenesis
2,3,7,8-tetrachlorodibenzo-p-dioxin induces CYP1B1 expression in human luteinized granulosa cells.
Carcinogenesis
5,7-Dimethoxyflavone downregulates CYP1A1 expression and benzo[a]pyrene-induced DNA binding in Hep G2 cells.
Carcinogenesis
6-Prenylnaringenin from Hops Disrupts ER?-mediated Downregulation of CYP1A1 to Facilitate Estrogen Detoxification.
Carcinogenesis
A Case-Control and a Family-Based Association Study Revealing an Association between CYP2E1 Polymorphisms and Nasopharyngeal Carcinoma Risk in Cantonese.
Carcinogenesis
A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach.
Carcinogenesis
A CRISPR/Cas9 Whole-Genome Screen Identifies Genes Required for Aryl Hydrocarbon Receptor-Dependent Induction of Functional CYP1A1.
Carcinogenesis
A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction.
Carcinogenesis
A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma.
Carcinogenesis
A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis.
Carcinogenesis
A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis.
Carcinogenesis
Action of curcumin on the cytochrome P450-system catalyzing the activation of aflatoxin B1.
Carcinogenesis
Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2.
Carcinogenesis
Alcohol and cancer: an overview with special emphasis on the role of acetaldehyde and cytochrome P450 2E1.
Carcinogenesis
Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.
Carcinogenesis
Alkylation of cellular macromolecules and target specificity of carcinogenic nitrosodialkylamines: metabolic activation by cytochromes P450 2B1 and 2E1.
Carcinogenesis
Alterations in ubiquitin ligase Siah-2 and its corepressor N-CoR after P-MAPA immunotherapy and anti-androgen therapy: new therapeutic opportunities for non-muscle invasive bladder cancer.
Carcinogenesis
An alternatively spliced cytochrome P4501A1 in human brain fails to bioactivate polycyclic aromatic hydrocarbons to DNA-reactive metabolites.
Carcinogenesis
Analyses of bulky DNA adduct levels in human breast tissue and genetic polymorphisms of cytochromes P450 (CYPs), myeloperoxidase (MPO), quinone oxidoreductase (NQO1), and glutathione S-transferases (GSTs).
Carcinogenesis
Analysis of chloroethane toxicity and carcinogenicity including a comparison with bromoethane.
Carcinogenesis
Analysis of CYP1A1 induction in single cells of urothelial cell populations by flow cytometry.
Carcinogenesis
Anti-carcinogenic potential of Euphorbia neriifolia leaves and isolated flavonoid against N-nitrosodiethylamine-induced renal carcinogenesis in mice.
Carcinogenesis
Aryl hydrocarbon hydroxylase and polycyclic hydrocarbon tumorigenesis: effect of the enzyme inhibitor 7,8-benzoflavone on tumorigenesis and macromolecule binding.
Carcinogenesis
Aryl hydrocarbon hydroxylase, epoxide hydrase, and 7,12-dimethylbenz(a)anthracene-produced skin tumorigenesis in the mouse.
Carcinogenesis
Aryl hydrocarbon receptor plays a significant role in mediating airborne particulate-induced carcinogenesis in mice.
Carcinogenesis
Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice.
Carcinogenesis
Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer.
Carcinogenesis
Association of mitochondrial deoxyribonucleic acid mutation with polymorphism in CYP2E1 gene in oral carcinogenesis.
Carcinogenesis
Azadirachta indica leaf extract modulates initiation phase of murine forestomach tumorigenesis.
Carcinogenesis
Azadirachta indica modulates carcinogen biotransformation and reduced glutathione at peri-initiation phase of benzo(a)pyrene induced murine forestomach tumorigenesis.
Carcinogenesis
Benzo[g,h,i]perylene synergistically transactivates benzo[a]pyrene-induced CYP1A1 gene expression by aryl hydrocarbon receptor pathway.
Carcinogenesis
Betel quid containing safrole enhances metabolic activation of tobacco specific 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Carcinogenesis
Bioactivation of the tobacco carcinogens 4-aminobiphenyl (4-ABP) and 2-amino-9H-pyrido[2,3-b]indole (A?C) in human bladder RT4 cells.
Carcinogenesis
Cancer prevention by bovine lactoferrin and underlying mechanisms--a review of experimental and clinical studies.
Carcinogenesis
Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential.
Carcinogenesis
Characterization of a wound-inducible cytochrome P450 gene ( CYP72A29) that is down-regulated during crown gall tumorigenesis in potato tuber.
Carcinogenesis
Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism.
Carcinogenesis
Chemoprevention of 2-amino-1-methyl-6-phenyli-midazo 4,5-b pyridine-induced carcinogen-DNA adducts by Chinese cabbage in rats.
Carcinogenesis
Chemopreventive potential of thiol conjugates of isothiocyanates for lung cancer and a urinary biomarker of dietary isothiocyanates.
Carcinogenesis
Co-carcinogenic effect of cyclohexanol on the development of preneoplastic lesions in a rat hepatocarcinogenesis model.
Carcinogenesis
Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.
Carcinogenesis
Comparative Expression Analysis of Cytochrome P450 1A1, Cytochrome P450 1B1 and Nuclear Receptors in the Female Genital and Colorectal Tissues of Human and Pigtailed Macaque.
Carcinogenesis
Comparative Levels of O6-Methylguanine, Pyridyloxobutyl-, and Pyridylhydroxybutyl-DNA Adducts in Lung and Liver of Rats Treated Chronically with the Tobacco-specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Carcinogenesis
Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.
Carcinogenesis
Comparison of rat hepatocyte and differentiated hepatoma cell line cultures as bio indicators of CYP 1A1 inducers in urban air.
Carcinogenesis
Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues.
Carcinogenesis
Comprehensive computational target fishing approach to identify Xanthorrhizol putative targets.
Carcinogenesis
Constitutive expression and localization of cytochrome P-450 1A1 in rat and human brain: presence of a splice variant form in human brain.
Carcinogenesis
Constitutive regulation of CYP1B1 by the aryl hydrocarbon receptor (AhR) in pre-malignant and malignant mammary tissue.
Carcinogenesis
Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis.
Carcinogenesis
Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT.
Carcinogenesis
CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies.
Carcinogenesis
CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis.
Carcinogenesis
CYP1A1 and GSTP1 gene variations in breast cancer: a systematic review and case-control study.
Carcinogenesis
CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case-control study within a large-scale population-based prospective study.
Carcinogenesis
CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations.
Carcinogenesis
CYP1A2 164 A-->C polymorphism, cigarette smoking, consumption of well-done red meat and risk of developing colorectal adenomas and carcinomas.
Carcinogenesis
Cyp1b1 exerts opposing effects on intestinal tumorigenesis via exogenous and endogenous substrates.
Carcinogenesis
CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma.
Carcinogenesis
CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers.
Carcinogenesis
CYP24A1 and CYP27B1 Polymorphisms Modulate Vitamin D Metabolism in Colon Cancer Cells.
Carcinogenesis
CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells.
Carcinogenesis
CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload.
Carcinogenesis
CYP2E1 polymorphisms and gene-environment interactions in the risk of upper aerodigestive tract cancers among Indians.
Carcinogenesis
CYP2E1 rs2031920, COMT rs4680 Polymorphisms, Cigarette Smoking, Alcohol Use and Lung Cancer Risk in a Japanese Population.
Carcinogenesis
CYP3A5 suppresses metastasis of lung adenocarcinoma through ATOH8/Smad1 axis.
Carcinogenesis
Cytochrome P-450 and acetyltransferase expression as biomarkers of carcinogen-DNA adduct levels and human cancer susceptibility.
Carcinogenesis
Cytochrome P1B1 (CYP1B1) polymorphisms and ovarian cancer risk: a meta-analysis.
Carcinogenesis
Cytochrome P450 1B1 (CYP1B1) gene polymorphisms as predictors of anticancer drug activity: studies with in vitro models.
Carcinogenesis
Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation.
Carcinogenesis
Cytochrome P450 1B1 expression in rat esophageal tumorigenesis promoted by gastric and duodenal reflux.
Carcinogenesis
Cytochrome P450 1B1 gene polymorphisms and postmenopausal endometrial cancer risk.
Carcinogenesis
Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse.
Carcinogenesis
Cytochrome P450 1B1 inhibition suppresses tumorigenicity of prostate cancer via caspase-1 activation.
Carcinogenesis
Cytochrome P450 1B1 promotes cancer cell survival via specificity protein 1 (Sp1)-mediated suppression of death receptor 4.
Carcinogenesis
Cytochrome P450 1B1, a new keystone in gene-environment interactions related to human head and neck cancer?
Carcinogenesis
Cytochrome P450 1B1, a novel chemopreventive target for benzo[a]pyrene-initiated human esophageal cancer.
Carcinogenesis
Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies.
Carcinogenesis
Cytochrome P450 2A13 mediates the neoplastic transformation of human bronchial epithelial cells at a low concentration of aflatoxin B1.
Carcinogenesis
Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells.
Carcinogenesis
Cytochrome P450 2E1 DraI polymorphisms in lung cancer in minority populations.
Carcinogenesis
Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats.
Carcinogenesis
Cytochrome P450 2E1: Its Clinical Aspects and a Brief Perspective on the Current Research Scenario.
Carcinogenesis
Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.
Carcinogenesis
Cytochrome P450 isoforms. Regulation during infection, inflammation and by cytokines.
Carcinogenesis
Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma.
Carcinogenesis
Cytochrome P450 Mediated Pulmonary Metabolism of Carcinogens: Regulation and Cross-talk in Lung Carcinogenesis.
Carcinogenesis
Cytotoxicity and genotoxicity of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol in CYP1A1-expressing human fibroblasts quantitatively correlate with CYP1A1 expression level.
Carcinogenesis
D15 Effects of acetylsalicylic acid administration on liver CYP1A, UGT and antioxidant enzymes in a rat model of dimethylbenzanthracene (DMBA)-induced mammary carcinogenesis.
Carcinogenesis
Decreased expression of cytochrome P450 2E1 is associated with poor prognosis of hepatocellular carcinoma.
Carcinogenesis
Decreased expression of cytochrome P450 protein in non-malignant colonic tissue of patients with colonic adenoma.
Carcinogenesis
Detection and Quantification of Specific DNA Adducts by Liquid Chromatography-Tandem Mass Spectrometry in the Livers of Rats Given Estragole at the Carcinogenic Dose.
Carcinogenesis
Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ culture.
Carcinogenesis
Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.
Carcinogenesis
Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.
Carcinogenesis
Dibenzyl trisulfide binds to and competitively inhibits the cytochrome P450 1A1 active site without impacting the expression of the aryl hydrocarbon receptor.
Carcinogenesis
Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China.
Carcinogenesis
Dietary protein, aryl hydrocarbon hydroxylase and chemical carcinogenesis in rats.
Carcinogenesis
Dietary soya isoflavones and breast carcinogenesis: a perspective from a cell-culture model.
Carcinogenesis
Differences in butadiene adduct formation between rats and mice not due to selective inhibition of CYP2E1 by butadiene metabolites.
Carcinogenesis
Differences in proteomic profiles between yak and three cattle strains provide insights into molecular mechanisms underlying high-altitude adaptation.
Carcinogenesis
Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes.
Carcinogenesis
Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol.
Carcinogenesis
Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.
Carcinogenesis
Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CYP1A2 gene.
Carcinogenesis
Dimethylbenzanthracene tumorigenesis and aryl hydrocarbon hydroxylase in mouse skin: inhibition by 7,8-benzoflavone.
Carcinogenesis
Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo.
Carcinogenesis
Distribution of soluble epoxide hydrolase, cytochrome P450 2C8, 2C9 and 2J2 in human malignant neoplasms.
Carcinogenesis
Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis.
Carcinogenesis
DNA damage caused by reactive oxygen species originating from a copper-dependent oxidation of the 2-hydroxy catechol of estradiol.
Carcinogenesis
DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung.
Carcinogenesis
Dose dependent inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice.
Carcinogenesis
Down-regulation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced CYP1A2 expression is associated with bovine lactoferrin inhibition of MeIQx-induced liver and colon carcinogenesis in rats.
Carcinogenesis
Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase.
Carcinogenesis
Effect of carotenoid lutein on N-nitrosodiethylamine-induced hepatocellular carcinoma and its mechanism of action.
Carcinogenesis
Effect of chronic dietary ethanol in the promotion of N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats.
Carcinogenesis
Effect of cigarette smoke on hepatic and pulmonary cytochromes P450 in mouse: evidence for CYP2E1 induction in lung.
Carcinogenesis
Effect of cigarette smoke on mutagenic activation of environmental carcinogens by cytochrome P450 2A8 and inactivation by glucuronidation in hamster liver.
Carcinogenesis
Effect of the co-administration of phenobarbital, quercetin and mancozeb on nitrosomethylurea-induced pancreatic tumors in rats.
Carcinogenesis
Effects of 3-methylcholanthrene on gene expression profiling in the rat using cDNA microarray analyses.
Carcinogenesis
Effects of alpha-naphthyl isothiocyanate and a heterocyclic amine, PhIP, on cytochrome P-450, mutagenic activation of various carcinogens and glucuronidation in rat liver.
Carcinogenesis
Effects of citrus phytochemicals on liver and lung cytochrome P450 activity and on the in vitro metabolism of the tobacco-specific nitrosamine NNK.
Carcinogenesis
Effects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of caffeine, oestrone and chlorzoxazone metabolism.
Carcinogenesis
Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat.
Carcinogenesis
Effects of diethyl maleate on aryl hydrocarbon hydroxylase and on 3-methyl-cholanthrene-induced skin tumorigenesis in rats and mice.
Carcinogenesis
Effects of genetically different strains of mice on the microsomal activation of 2-aminofluorene.
Carcinogenesis
Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models.
Carcinogenesis
Effects of natural polyphenols on aflatoxin B1 activation in a reconstituted microsomal monooxygenase system.
Carcinogenesis
Effects of tobacco smoke on the gene expression of the Cyp1a, Cyp2b, Cyp2e, and Cyp3a subfamilies in mouse liver and lung: relation to single strand breaks of DNA.
Carcinogenesis
Effects of watercress consumption on urinary metabolites of nicotine in smokers.
Carcinogenesis
Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer.
Carcinogenesis
Emamectin benzoate induced enzymatic and transcriptional alternation in detoxification mechanism of predatory beetle Paederus fuscipes (Coleoptera: Staphylinidae) at the sublethal concentration.
Carcinogenesis
Enhancement of hepatocarcinogenesis and induction of specific cytochrome P450-dependent monooxygenase activities by the barbiturates allobarbital, aprobarbital, pentobarbital, secobarbital and 5-phenyl- and 5-ethylbarbituric acids.
Carcinogenesis
Enhancement of thyroid and hepatocarcinogenesis by 1,4-bis[2-(3,5- dichloropyridyloxy)]benzene in rats at doses that cause maximal induction of CYP2B.
Carcinogenesis
Enhancing effects of 2-amino-4,5-diphenylthiazole-induced polycystic kidneys on renal carcinogenesis in rats treated with dimethylnitrosamine.
Carcinogenesis
Enhancing effects of a high fat diet on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced lung tumorigenesis in female A/J mice.
Carcinogenesis
EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange.
Carcinogenesis
Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test.
Carcinogenesis
Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis.
Carcinogenesis
Estrogen metabolite ratio: Is the 2-hydroxyestrone to 16?-hydroxyestrone ratio predictive for breast cancer?
Carcinogenesis
Estrogen receptor alpha promotes smoking-carcinogen-induced lung carcinogenesis via cytochrome P450 1B1.
Carcinogenesis
Ethanol enhances retinoic acid metabolism into polar metabolites in rat liver via induction of cytochrome P4502E1.
Carcinogenesis
Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions.
Carcinogenesis
Evaluation of CYP1B1 Expression, Oxidative Stress and Phase 2 Detoxification Enzyme Status in Oral Squamous Cell Carcinoma Patients.
Carcinogenesis
Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.
Carcinogenesis
Exposing ferrets to cigarette smoke and a pharmacological dose of beta-carotene supplementation enhance in vitro retinoic acid catabolism in lungs via induction of cytochrome P450 enzymes.
Carcinogenesis
Expression and induction of cytochrome P-450 1A1 and P-450 2D subfamily in the rat glioma C6 cell line.
Carcinogenesis
Expression and regulation of cytochrome P-450I genes (CYP1A1 and CYP1A2) in the rat alimentary tract.
Carcinogenesis
Expression of CYP1A1 and CYP1B1 depends on cell-specific factors in human breast cancer cell lines: role of estrogen receptor status.
Carcinogenesis
Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas.
Carcinogenesis
Expression of CYP1C1 and CYP1A in Fundulus heteroclitus during PAH-induced carcinogenesis.
Carcinogenesis
Expression of recombinant human cytochrome P450 1A2 in Escherichia coli bacterial mutagenicity tester strain.
Carcinogenesis
Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis.
Carcinogenesis
Expression of two cytochromes P450 involved in carcinogen activation in a human colon cell line.
Carcinogenesis
Expression profile of CYP1A1 and CYP1B1 enzymes in colon and bladder tumors.
Carcinogenesis
Expression profiling of CYP1B1 in oral squamous cell carcinoma: counterintuitive downregulation in tumors.
Carcinogenesis
Expression, induction and regulation of the cytochrome P450 monooxygenase system in the rat glioma C6 cell line.
Carcinogenesis
Fetal mouse Cyp1b1 and transplacental carcinogenesis from maternal exposure to dibenzo(a,l)pyrene.
Carcinogenesis
From the Cover: PhIP/DSS-Induced Colon Carcinogenesis in CYP1A-Humanized Mice and the Possible Role of Lgr5+ Stem Cells.
Carcinogenesis
Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer.
Carcinogenesis
Functional significance of cytochrome P450 1B1 in endometrial carcinogenesis.
Carcinogenesis
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.
Carcinogenesis
Gene polymorphism of cytochrome P450 significantly affects lung cancer susceptibility.
Carcinogenesis
Genetic analysis of colon tumors induced by a dietary carcinogen PhIP in CYP1A humanized mice: Identification of mutation of ?-catenin/Ctnnb1 as the driver gene for the carcinogenesis.
Carcinogenesis
Genetic and epigenetic regulation of AHR gene expression in MCF-7 breast cancer cells: Role of the proximal promoter GC-rich region.
Carcinogenesis
Genetic damage induced by organic extract of coke oven emissions on human bronchial epithelial cells.
Carcinogenesis
Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse.
Carcinogenesis
Genetic differences in the induction of aryl hydrocarbon hydroxylase and benzo(a)pyrene carcinogenesis in C3H/He and DBA/2 strains of mice.
Carcinogenesis
Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection.
Carcinogenesis
Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison.
Carcinogenesis
Genetic polymorphisms of CYP2E1 and risk of colorectal adenomas in the Self Defense Forces Health Study.
Carcinogenesis
Genetic polymorphisms of cytochrome P450 1A1 and risk of gallbladder cancer.
Carcinogenesis
Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant.
Carcinogenesis
Genistein Induces Cytochrome P450 1B1 Gene Expression and Cell Proliferation in Human Breast Cancer MCF-7 Cells.
Carcinogenesis
Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis.
Carcinogenesis
Grape seed proanthocyanidin suppression of breast cell carcinogenesis induced by chronic exposure to combined 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene.
Carcinogenesis
Hemizygous mice for the angiotensin II type 2 receptor gene have attenuated susceptibility to azoxymethane-induced colon tumorigenesis.
Carcinogenesis
HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism.
Carcinogenesis
Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats.
Carcinogenesis
Heterologous expression of rat P450 2E1 in a mammalian cell line: in situ metabolism and cytotoxicity of N-nitrosodimethylamine.
Carcinogenesis
High-throughput screening assays for CYP2B6 metabolism and inhibition using fluorogenic vivid substrates.
Carcinogenesis
Higher CYP2E1 Activity Correlates with Hepatocarcinogenesis Induced by Diethylnitrosamine.
Carcinogenesis
Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells.
Carcinogenesis
Human CYP1B1 Leu432Val gene polymorphism: ethnic distribution in African-Americans, Caucasians and Chinese; oestradiol hydroxylase activity; and distribution in prostate cancer cases and controls.
Carcinogenesis
Human CYP2D6 gene polymorphism in Slovene cancer patients and healthy controls.
Carcinogenesis
Hypomethylation of the XRE -1383 site is associated with the upregulation of CYP1A1 in gastric adenocarcinoma.
Carcinogenesis
Identification of a novel co-transcription of P450/1A1 with telomerase in A549.
Carcinogenesis
Identification of core genes and outcome in gastric cancer using bioinformatics analysis.
Carcinogenesis
Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse.
Carcinogenesis
Identification of Energy Metabolism Genes for the Prediction of Survival in Hepatocellular Carcinoma.
Carcinogenesis
Identification of gene and microRNA changes in response to smoking in human airway epithelium by bioinformatics analyses.
Carcinogenesis
Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository.
Carcinogenesis
Identification of molecular target genes and key pathways in hepatocellular carcinoma by bioinformatics analysis.
Carcinogenesis
Identification of Potential Therapeutic Gene Markers in Nasopharyngeal Carcinoma Based on Bioinformatics Analysis.
Carcinogenesis
Identification of structural properties influencing the metabolism of polycyclic aromatic hydrocarbons by cytochrome P450 1A1.
Carcinogenesis
Immunohistochemical study of CYP2E1 in hepatocellular carcinoma carcinogenesis: examination with newly prepared anti-human CYP2E1 antibody.
Carcinogenesis
Importance of CYP1A1 polymorphism and its transcriptional regulation in ovarian and endometrial cancer.
Carcinogenesis
In situ hybridization and immunohistochemical analysis of cytochrome P450 1B1 expression in human normal tissues.
Carcinogenesis
In vitro transformation of human bronchial epithelial cells by diesel exhaust particles: gene expression profiling and early toxic responses.
Carcinogenesis
Increased expression of the retinoic acid-metabolizing enzyme CYP26A1 during the progression of cervical squamous neoplasia and head and neck cancer.
Carcinogenesis
Independent and Combined Effects of Ethanol Self-administration and Nicotine Treatment on Hepatic CYP2E1 in African Green Monkeys.
Carcinogenesis
Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytochrome P450 in female F344 rats.
Carcinogenesis
Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice.
Carcinogenesis
Induction and suppression of cytochrome P450 isoenzymes and generation of oxygen radicals by procymidone in liver, kidney and lung of CD1 mice.
Carcinogenesis
Induction of CYP1A by benzo[k]fluoranthene in human hepatocytes: CYP1A1 or CYP1A2?
Carcinogenesis
Induction of CYP1A1 and CYP2E1 in rat liver by histamine: binding and kinetic studies.
Carcinogenesis
Induction of CYP1A1. The AhR/DRE paradigm: transcription, receptor regulation, and expanding biological roles.
Carcinogenesis
Induction of cytochrome P450 1A1 expression by ginsenoside Rg1 and Rb1 in HepG2 cells.
Carcinogenesis
Induction of cytochrome P450 1A1 in MCF-7 human breast cancer cells by 4-chlorobiphenyl (PCB3) and the effects of its hydroxylated metabolites on cellular apoptosis.
Carcinogenesis
Induction of cytochrome P450 isoforms by carcinogenic aromatic amines and carcinogenic susceptibility of rodent animals.
Carcinogenesis
Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: research history, evolutionary aspect, relation to tumorigenesis, and mechanism.
Carcinogenesis
Influence of genetic susceptibility on the urinary excretion of 8-hydroxydeoxyguanosine of firefighters.
Carcinogenesis
Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans.
Carcinogenesis
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone mouse lung tumorigenesis by arylalkynes, mechanism-based inactivators of cytochrome P450.
Carcinogenesis
Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids.
Carcinogenesis
Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.
Carcinogenesis
Inhibition of cytochrome P450 1A1 by antisense phosphorothioate oligonucleotide in Hepa lclc7 cells.
Carcinogenesis
Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin.
Carcinogenesis
Inhibition of vinyl carbamate-induced hepatotoxicity, mutagenicity, and tumorigenicity by isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2- yl)carbamoyl]acetate (YH439).
Carcinogenesis
Inhibitory effect of linoleic acid on transformation of IEC6 intestinal cells by in vitro azoxymethane treatment.
Carcinogenesis
Interactions between detoxifying enzyme polymorphisms and susceptibility to cancer.
Carcinogenesis
Interstrain differences in susceptibility to liver carcinogenesis initiated by N-nitrosodiethylamine and its promotion by phenobarbital in C57BL/6NCr, C3H/HeNCrMTV- and DBA/2NCr mice.
Carcinogenesis
Involvement of caspase-9 but not caspase-8 in the anti-apoptotic effects of estradiol and 4-OH-Estradiol in MCF-7 human breast cancer cells.
Carcinogenesis
Isolation and sequencing of the cDNA of a novel cytochrome P450 from rat oesophagus.
Carcinogenesis
Isothiocyanates and freeze-dried strawberries as inhibitors of esophageal cancer.
Carcinogenesis
Isothiocyanates and plant polyphenols as inhibitors of lung and esophageal cancer.
Carcinogenesis
iTRAQ-based quantitative proteomics analysis of the hepatoprotective effect of melatonin on ANIT-induced cholestasis in rats.
Carcinogenesis
Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1.
Carcinogenesis
Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice.
Carcinogenesis
Localization of Cytochrome P4502E1 Enzyme in Normal and Cancerous Gastric Mucosa and Association with Its Genetic Polymorphism in Unoperated and Remnant Stomach.
Carcinogenesis
Low synthesis of retinoic acid due to impaired cytochrome P450 1a1 expression in mouse xeroderma pigmentosum fibroblasts.
Carcinogenesis
Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway.
Carcinogenesis
Mechanism Investigation of Rifampicin-Induced Liver Injury Using Comparative Toxicoproteomics in Mice.
Carcinogenesis
Mechanism of inhibition of benzo[a]pyrene-induced forestomach cancer in mice by dietary curcumin.
Carcinogenesis
Mechanisms of alcohol-associated cancers: introduction and summary of the symposium.
Carcinogenesis
Metabolic cytochrome P450 genotypes and assessment of individual susceptibility to lung cancer.
Carcinogenesis
Metabolism of (+)-trans-benzo[a]pyrene-7,8-dihydrodiol by 3-methylcholanthrene-induced rat liver homogenates.
Carcinogenesis
Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human cytochrome P4501B1.
Carcinogenesis
Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1.
Carcinogenesis
Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase.
Carcinogenesis
Metal-mediated DNA damage induced by curcumin in the presence of human cytochrome P450 isozymes.
Carcinogenesis
Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.
Carcinogenesis
Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1.
Carcinogenesis
Microarray analysis for the identification of specific proteins and functional modules involved in the process of hepatocellular carcinoma originating from cirrhotic liver.
Carcinogenesis
Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review.
Carcinogenesis
Microsomal function in hepatitis B surface antigen healthy carriers: assessment of cytochrome P450 1A2 activity by the 14C-caffeine breath test.
Carcinogenesis
Modulation of benzo[a]pyrene induced immunotoxicity in mice actively immunized with a B[a]P-diphtheria toxoid conjugate.
Carcinogenesis
Modulation of benzo[a]pyrene-DNA adduct formation by CYP1 inducer and inhibitor.
Carcinogenesis
Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options.
Carcinogenesis
Modulation of Estrogen Chemical Carcinogenesis by Botanical Supplements used for Postmenopausal Women's Health.
Carcinogenesis
Modulatory effect of Morus indica against two-stage skin carcinogenesis in Swiss albino mice: possible mechanism by inhibiting aryl hydrocarbon hydroxylase.
Carcinogenesis
Molecular mechanisms, immune cell infiltration, and potential drugs for prostate cancer.
Carcinogenesis
Monooxygenase system in Guerins carcinoma of rats under conditions of ?-3 polyunsaturated fatty acids administration.
Carcinogenesis
Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Carcinogenesis
Mouse skin tumorigenesis and induction of aryl hydrocarbon hydroxylase by tobacco smoke fractions.
Carcinogenesis
N-Nitrosobenzylmethylamine hydroxylation and coumarin 7-hydroxylation: catalysis by rat esophageal microsomes and cytochrome P450 2A3 and 2A6 enzymes.
Carcinogenesis
Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NF?B and PCNA expression.
Carcinogenesis
Natural anticarcinogens, carcinogens, and changing patterns in cancer: some speculation.
Carcinogenesis
Neonatal phenobarbital imprints overexpression of cytochromes P450 with associated increase in tumorigenesis and reduced life span.
Carcinogenesis
Novel flavonoids as anti-cancer agents: mechanisms of action and promise for their potential application in breast cancer.
Carcinogenesis
Nuclear transcription factor Oct-1 binds to the 5'-upstream region of CYP1A1 and negatively regulates its expression.
Carcinogenesis
Nutritional calcium modulates colonic expression of vitamin D receptor and pregnane X receptor target genes.
Carcinogenesis
Obacunone exhibits anti-proliferative and anti-aromatase activity in vitro by inhibiting the p38 MAPK signaling pathway in MCF-7 human breast adenocarcinoma cells.
Carcinogenesis
Oestradiol metabolism and androgen receptor genotypes are associated with right ventricular function.
Carcinogenesis
Olfactory toxicity of diethyldithiocarbamate (DDTC) and disulfiram and the protective effect of DDTC against the olfactory toxicity of dichlobenil.
Carcinogenesis
Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate.
Carcinogenesis
Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm.
Carcinogenesis
Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation.
Carcinogenesis
Overcoming Taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin.
Carcinogenesis
Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis.
Carcinogenesis
p-Nitrophenol and glutathione response in medaka (Oryzias latipes) exposed to MX, a drinking water carcinogen.
Carcinogenesis
Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters.
Carcinogenesis
Perturbation of xenobiotic metabolism in Dreissena polymorpha model exposed in situ to surface water (Lake Trasimene) purified with various disinfectants.
Carcinogenesis
Phenobarbital stimulation of cytochrome P-450 and aminopyrine N-demethylase in hyperplastic liver nodules during LD-ethionine carcinogenesis.
Carcinogenesis
Phenobarbital: a non-genotoxic agent which induces the repair of O6-methylguanine from hepatic DNA.
Carcinogenesis
Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis.
Carcinogenesis
Pinocembrin attenuates benzo(a)pyrene-induced CYP1A1 expression through multiple pathways: An in vitro and in vivo study.
Carcinogenesis
Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2.
Carcinogenesis
Polycyclic aromatic hydrocarbon-induced CYP1B1 activity is suppressed by perillyl alcohol in MCF-7 cells.
Carcinogenesis
Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo.
Carcinogenesis
Polymorphism in CYP1A1 and CYP2D6 genes: possible association with susceptibility to lung cancer.
Carcinogenesis
Polymorphism of CYP1A1 gene variants rs4646903 and rs1048943 relation to the incidence of cervical cancer in Chhattisgarh.
Carcinogenesis
Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol.
Carcinogenesis
Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose.
Carcinogenesis
Polymorphisms related to estrogen and xenobiotic metabolism in healthy Turkish women.
Carcinogenesis
Possible mechanism of Sudan III-induced prevention of chemical carcinogenesis in rats.
Carcinogenesis
Possible Mechanisms of Ethanol-Mediated Colorectal Carcinogenesis: The Role of Cytochrome P4502E1, Etheno-DNA Adducts, and the Anti-Apoptotic Protein Mcl-1.
Carcinogenesis
Possible similar role of cytochrome P450 in primordial evolution of species and in chemical carcinogenesis.
Carcinogenesis
Potential role of CYP1B1 in the development and treatment of metabolic diseases.
Carcinogenesis
Prediction and validation of apoptosis through cytochrome P450 activation by benzo[a]pyrene.
Carcinogenesis
Predictive modes of action of pesticides in uterine adenocarcinoma development in rats.
Carcinogenesis
Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin.
Carcinogenesis
Preferred Binding Orientations of Phenacetin in CYP 1A1 and 1A2 are Associated with Isoform-selective Metabolism.
Carcinogenesis
Presence of a retinoid responsive element in the promoter region of the human cytochrome P4501A1 gene.
Carcinogenesis
Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.
Carcinogenesis
Principal xenobiotic-metabolizing enzyme systems in human head and neck squamous cell carcinoma.
Carcinogenesis
Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking.
Carcinogenesis
Prognostic implications of cell division cycle protein 45 expression in hepatocellular carcinoma.
Carcinogenesis
Promoter methylation status in genes related with inflammation, nitrosative stress and xenobiotic metabolism in low-level benzene exposure: Searching for biomarkers of oncogenesis.
Carcinogenesis
Protection against tumorigenesis by 3-methylcholanthrene in mice by beta-naphthoflavone as a function of inducibility of methylcholanthrene metabolism.
Carcinogenesis
Quercetin suppresses cytochrome P450 mediated ROS generation and NF?B activation to inhibit the development of 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinomas.
Carcinogenesis
Quinazolinone derivative BNUA-3 ameliorated [NDEA+2-AAF]-induced liver carcinogenesis in SD rats by modulating AhR-CYP1B1-Nrf2-Keap1 pathway.
Carcinogenesis
Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate.
Carcinogenesis
Rat oesophageal cytochrome P450 (CYP) monooxygenase system: comparison to the liver and relevance in N-nitrosodiethylamine carcinogenesis.
Carcinogenesis
Re: Hemminki,K., Dickey,C., Karlsson,S., Bell,D., Hsu,Y., Tsai,W.-Y., Mooney,L.A., Savela,K. and Perera,F.P. (1997) Aromatic DNA adducts in foundry workers in relation to exposure, lifestyle and CYP1A1 and glutathione transferase M1 genotype. Carcinogenesis, 18, 345-350.
Carcinogenesis
Re: London,S.J. et al. (1997) Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County. Carcinogenesis, 18, 1203-1214.
Carcinogenesis
Real-time polymerase chain reaction analysis of CYP1B1 gene expression in human liver.
Carcinogenesis
Red Clover Aryl Hydrocarbon Receptor (AhR) and Estrogen Receptor (ER) Agonists Enhance Genotoxic Estrogen Metabolism.
Carcinogenesis
Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment.
Carcinogenesis
Regioselective 2-hydroxylation of 17beta-estradiol by rat cytochrome P4501B1.
Carcinogenesis
Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis.
Carcinogenesis
Renal Transcriptomics Reveals the Carcinogenic Mechanism of Ethyl Carbamate in Musalais.
Carcinogenesis
Respirable coal dust particles modify cytochrome P4501A1 (CYP1A1) expression in rat alveolar cells.
Carcinogenesis
Retinoic acid-metabolizing enzyme cytochrome P450 26A1 promotes skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene.
Carcinogenesis
Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population.
Carcinogenesis
RNA expressions of AHR, ARNT and CYP1B1 are influenced by AHR Arg554Lys polymorphism.
Carcinogenesis
Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.
Carcinogenesis
Role of CYP2A5 in the Bioactivation of the Lung Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in Mice.
Carcinogenesis
Role of cytochrome P450 1a1 and 1b1 in the metabolic activation of 7,12-dimethylbenz[a]anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation.
Carcinogenesis
Role of Hepatic and Intestinal P450 Enzymes in the Metabolic Activation of the Colon Carcinogen Azoxymethane in Mice.
Carcinogenesis
Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol.
Carcinogenesis
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
Carcinogenesis
Role of the modulation of CYP1A1 expression and activity in chemoprevention: A mini review.
Carcinogenesis
Safety assessment for non-genotoxic rodent carcinogens: curves, low-dose extrapolations, and mechanisms in carcinogenesis.
Carcinogenesis
Screening and analysis of pathogenic genes during DMBA-induced buccal mucosa carcinogenesis in golden hamsters.
Carcinogenesis
Screening and identification of potential target genes in head and neck cancer using bioinformatics analysis.
Carcinogenesis
Sequential action of phase I and II enzymes cytochrome p450 1B1 and glutathione S-transferase P1 in mammary estrogen metabolism.
Carcinogenesis
Serum induces a transcriptional activation of CYP1A1 gene in HepG2 independently of the AhR pathway.
Carcinogenesis
Silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic activity: A study in human keratinocytes and human hepatoma cells.
Carcinogenesis
Skin and salivary gland carcinogenicity of 7,12-dimethylbenz[a]anthracene is equivalent in the presence or absence of aryl hydrocarbon receptor.
Carcinogenesis
Smoking and susceptibility to thyroid cancer: an inverse association with CYP1A1 allelic variants.
Carcinogenesis
Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity.
Carcinogenesis
Steroid hormone synthesis by the ovarian stroma surrounding epithelial ovarian tumors: a potential mechanism in ovarian tumorigenesis.
Carcinogenesis
Structure-activity relationship and in vitro inhibition of human cytochrome CYP2A6 and CYP2A13 by flavonoids.
Carcinogenesis
Structure-activity relationships in polycyclic aromatic hydrocarbons: induction of microsomal aryl hydrocarbon hydroxylase and its possible importance in chemical carcinogenesis.
Carcinogenesis
Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands.
Carcinogenesis
Suppression of cytochrome P450 4B1: An early event in adrenocortical tumorigenesis.
Carcinogenesis
T-2 toxin upregulates the expression of human cytochrome P450 1A1 (CYP1A1) by enhancing NRF1 and Sp1 interaction.
Carcinogenesis
Target organ-specific inactivation of drug metabolizing enzymes in kidney of hamsters treated with estradiol.
Carcinogenesis
Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis.
Carcinogenesis
The ?-3 epoxide of eicosapentaenoic acid inhibits endothelial cell proliferation by p38 MAP kinase activation and cyclin D1/CDK4 down-regulation.
Carcinogenesis
The antitumour activity of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole in human gastric cancer models is mediated by AhR signalling.
Carcinogenesis
The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis.
Carcinogenesis
The clinical value and potential molecular mechanism of the downregulation of MAOA in hepatocellular carcinoma tissues.
Carcinogenesis
The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production.
Carcinogenesis
The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.
Carcinogenesis
The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cells.
Carcinogenesis
The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis.
Carcinogenesis
The effects of anti-inflammatory agents on skin tumor initiation and aryl hydrocarbon hydroxylase.
Carcinogenesis
The enhancing effect of ethanol on the mutagenic activation of N-nitrosomethylbenzylamine by cytochrome P450 2A in the rat oesophagus.
Carcinogenesis
The formation of 3-methylcholanthrene-initiated lung tumors correlates with induction of cytochrome P450IA1 by the carcinogen in fetal but not adult mice.
Carcinogenesis
The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo.
Carcinogenesis
The mechanism of Psoralen and Isopsoralen hepatotoxicity as revealed by hepatic gene expression profiling in SD rats.
Carcinogenesis
The model Ah-receptor agonist beta-naphthoflavone inhibits aflatoxin B1-DNA binding in vivo in rainbow trout at dietary levels that do not induce CYP1A enzymes.
Carcinogenesis
The role of aryl hydrocarbon hydroxylase in 7,12-dimethylbenz(a)anthracene skin tumorigenesis: on the mechanism of 7,8-benzoflavone inhibition of tumorigenesis.
Carcinogenesis
The role of CYP1A1 Msp1 gene polymorphisms on lung cancer development in Turkey.
Carcinogenesis
The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis.
Carcinogenesis
The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts.
Carcinogenesis
The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis.
Carcinogenesis
Time-dependent acetylsalicylic acid effects on liver CYP1A and antioxidant enzymes in a rat model of 7,12-dimethylbenzanthracene (DMBA)-induced mammary carcinogenesis.
Carcinogenesis
Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene.
Carcinogenesis
Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene.
Carcinogenesis
Transcriptome signature of liver tissue with divergent mutton odour and flavour using RNA deep sequencing.
Carcinogenesis
Transplacental lung carcinogenesis: a pharmacogenetic mouse model for the modulatory role of cytochrome P450 1A1 on lung cancer initiation.
Carcinogenesis
Unique cytochromes P450 in human brain: implication in disease pathogenesis.
Carcinogenesis
Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway.
Carcinogenesis
Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1.
Carcinogenesis
Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse.
Carcinogenesis
Using a combination of cytochrome P450 1B1 and beta-catenin for early diagnosis and prevention of colorectal cancer.
Carcinogenesis
Utilizing proteomic approach to identify nuclear translocation related serine kinase phosphorylation site of GNMT as downstream effector for benzo[a]pyrene.
Carcinogenesis
UXT antisense RNA 1 sever as a novel prognostic long non-coding RNA in early stage pancreatic ductal adenocarcinoma patients after receiving pancreaticoduodenectomy.
Carcinogenesis
Vitamin D-neutralizing CYP24A1 expression, oncogenic mutation states and histological findings of human papillary thyroid cancer.
Carcinogenesis
Vitamin K as a regulator of benzo(a)pyrene metabolism, mutagenesis, and carcinogenesis. Studies with rat microsomes and tumorigenesis in mice.
Carcinogenesis
Whole transcriptome analysis of chemically-induced hepatocellular carcinoma using RNA sequencing analysis.
Carcinogenesis
Xenobiotics and xenoestrogens in fish: modulation of cytochrome P450 and carcinogenesis.
Carcinogenesis
[A case-control study on the association between genetic polymorphisms of metabolic enzymes and the risk of colorectal cancer]
Carcinogenesis
[A role of aryl hydrocarbon hydroxylase inducibility in susceptibility to lung carcinogenesis]
Carcinogenesis
[Aryl hydrocarbon hydroxylase activity in the livers of mice of genetically different strains during chemical carcinogenesis]
Carcinogenesis
[Association of cytochrome P-450 1A1 (CYP1A1) gene polymorphism to smoking status and hematologic findings]
Carcinogenesis
[Bioactivation of xenobiotics by cytochrome P-448 and its role in the process of carcinogenesis]
Carcinogenesis
[Bioinformatics analysis of key genes and prognosis-related genes during the onset of hepatocellular carcinoma].
Carcinogenesis
[Chemical carcinogenesis and cytochrome P450: carcinogenic aromatic amine-induced P450 and hepatocarcinogenic susceptibility to the aromatic amine in the rodent]
Carcinogenesis
[Cloning and sequence analysis of human embryonic nasopharyngeal epithelial CYP2E1 cDNA]
Carcinogenesis
[Construction of thr461 --> Asn461 and Ile462 --> Val462 mutation vector of P4501A1 gene]
Carcinogenesis
[Effect of low doses of x-ray irradiation on the liver detoxication system in rats with transplanted Guerin's carcinoma].
Carcinogenesis
[Effects of CYP1A1 and GSTM1 gene polymorphisms and BPDE-DNA adducts on lung cancer].
Carcinogenesis
[Expression of human cytochrome P450 2E1 gene in embryonic nasopharynx, nasopharyngeal cancer cell lines and tissue]
Carcinogenesis
[Genetic polymorphism of cytochrome P4501A1 and susceptibility to laryngeal carcinoma]
Carcinogenesis
[Genetic polymorphisms of cytochrome P450 2E1 and glutathione S-transferase P1 and susceptibility to esophageal cancer]
Carcinogenesis
[Importance of aryl hydrocarbon hydroxylase in laryngeal oncogenesis. Preliminary data]
Carcinogenesis
[Regulation of human CYP1B1 and its role in carcinogenesis and estrogen homeostasis]
Carcinogenesis
[Stable expression of human cytochrome P450 2E1 cDNA in nasopharyngeal cancer cell line CNE-2]
Carcinogenesis
[The role of Cytochrom P4502E1 in Alcoholic Liver Disease and alcohol mediated carcinogenesis].
Carcinoma
11Beta-hydroxysteroid dehydrogenase 1 expression in squamous cell carcinomas of the head and neck.
Carcinoma
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes gene polymorphisms, NNK metabolites levels and urothelial carcinoma.
Carcinoma
?-Catenin signaling induces CYP1A1 expression by disrupting adherens junctions in Caco-2 human colon carcinoma cells.
Carcinoma
A comparison between lung carcinoma and a subcutaneous malignant tumor induced in rats by a 3,4-benzopyrene injection.
Carcinoma
A genetic polymorphism in the CYP1B1 gene in patients with squamous cell carcinoma of the esophagus: an Iranian Mashhad cohort study recruited over 10 years.
Carcinoma
A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population.
Carcinoma
A significantly joint effect between arsenic and occupational exposures and risk genotypes/diplotypes of CYP2E1, GSTO1 and GSTO2 on risk of urothelial carcinoma.
Carcinoma
Activation and overexpression of the aryl hydrocarbon receptor contribute to cutaneous squamous cell carcinomas: an immunohistochemical study.
Carcinoma
Activation of Fas receptor modulates cytochrome P450 3A4 expression in human colon carcinoma cells.
Carcinoma
Alterations in expression of CYP1A1 and NADPH-cytochrome P450 reductase during lung tumor development in SWR/J mice.
Carcinoma
Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions.
Carcinoma
Altered patterns of cutaneous xenobiotic metabolism in UVB-induced squamous cell carcinoma in SKH-1 hairless mice.
Carcinoma
Altered regulation of the cytochrome P4501A1 gene: novel inducer-independent gene expression in pulmonary carcinoma cell lines.
Carcinoma
Analysis of RNA from brush cytology detects changes in B2M, CYP1B1 and KRT17 levels with OSCC in tobacco users.
Carcinoma
Analysis of the role of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 gene in the risk of squamous cell carcinoma.
Carcinoma
Antimigraine Drug Avitriptan Is a Ligand and Agonist of Human Aryl Hydrocarbon Receptor That Induces CYP1A1 in Hepatic and Intestinal Cells.
Carcinoma
Antiproliferative and antioxidant potential of hesperetin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
Carcinoma
Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.
Carcinoma
Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo.
Carcinoma
Arsenite pretreatment attenuates benzo[a]pyrene cytotoxicity in a human lung adenocarcinoma cell line by decreasing cyclooxygenase-2 levels.
Carcinoma
Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls.
Carcinoma
Aryl hydrocarbon hydroxylase induction levels in patients with malignant tumors associated with smoking.
Carcinoma
Association and treatment response to capecitabine-based chemoradiotherapy with CYP2C9 polymorphism in head and neck cancer.
Carcinoma
Association between CYP1A1 Ile462Val Polymorphism and Oral Squamous Cell Carcinoma Susceptibility: Evidence from 13 Investigations.
Carcinoma
Association between cytochrome P450 1A1 (CYP1A1) gene polymorphisms and the risk of renal cell carcinoma: a meta-analysis.
Carcinoma
Association between GSTM1 and CYP1A1 polymorphisms and survival in oral cancer patients.
Carcinoma
Association between polymorphisms in the CYP1A1, CYP2E1 and GSTM1 genes, and smoking, alcohol and upper digestive tract carcinomas in a high-incidence area of northern China.
Carcinoma
Association of Androgen Receptor, Prostate-Specific Antigen, and CYP19 Gene Polymorphisms with Prostate Carcinoma and Benign Prostatic Hyperplasia in a North Indian Population.
Carcinoma
Association of aryl hydrocarbon receptor and cytochrome P4501B1 expressions in human non-small cell lung cancers.
Carcinoma
Association of cigarette smoking and CYP1A1 polymorphisms with adenocarcinoma of the lung by grades of differentiation.
Carcinoma
Association of combined CYP2E1 gene polymorphism with the risk for esophageal squamous cell carcinoma in Huai'an population, China.
Carcinoma
Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma.
Carcinoma
Association of cytochrome P450 2C9 polymorphism with locally advanced head and neck squamous cell carcinoma and response to concurrent cisplatin-based radical chemoradiation.
Carcinoma
Association of cytochrome P450 2E1 genetic polymorphisms with squamous cell carcinoma of the oesophagus.
Carcinoma
Association of Genetic Polymorphisms of Aldehyde Dehydrogenase-2 and Cytochrome P450 2E1-RsaI and Alcohol Consumption with Oral Squamous Cell Carcinoma.
Carcinoma
Association of Genetic Variants of CYP2C19 and CYP2D6 with Esophageal Squamous Cell Carcinoma Risk in Northern India, Kashmir.
Carcinoma
Association of NAD(P)H:quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci.
Carcinoma
Association of polymorphism in cytochrome P450 2C9 with susceptibility to head and neck cancer and treatment outcome.
Carcinoma
Association of poor metabolizers of cytochrome P450 2C19 with head and neck cancer and poor treatment response.
Carcinoma
Association of Smoking and XPG, CYP1A1, OGG1, ERCC5, ERCC1, MMP2, and MMP9 Gene Polymorphisms with the early detection and occurrence of Laryngeal Squamous Carcinoma.
Carcinoma
Association studies of CYP1A1 and GSTM1 polymorphisms with esophageal cancer risk: evidence-based meta-analyses.
Carcinoma
Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens.
Carcinoma
Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models.
Carcinoma
C-jun N-terminal kinase modulates 1,25-dihydroxyvitamin D3-induced cytochrome P450 3A4 gene expression.
Carcinoma
Carcinoma of the oral cavity in relation to aryl hydrocarbon hydroxylase inducibility, smoking and dental status.
Carcinoma
Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes.
Carcinoma
Changes in expression of drug-metabolizing enzymes by single-walled carbon nanotubes in human respiratory tract cells.
Carcinoma
Characterization of cytochrome P450 enzymes in human breast tissue from reduction mammaplasties.
Carcinoma
Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line.
Carcinoma
Characterization of the aryl hydrocarbon receptor and aryl hydrocarbon responsiveness in human ovarian carcinoma cell lines.
Carcinoma
Chromosomal region 15q21.1 is a frequent target of allelic imbalance in advanced breast carcinomas.
Carcinoma
Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells.
Carcinoma
Combination of polymorphisms from genes related to estrogen metabolism and risk of prostate cancers: the hidden face of estrogens.
Carcinoma
Combined analysis of germline polymorphisms of p53, GSTM1, GSTT1, CYP1A1, and CYP2E1: relation to the incidence rate of cervical carcinoma.
Carcinoma
Combined CYP1A1/GSTM1 at-risk genotypes are overrepresented in squamous cell lung carcinoma patients but underrepresented in elderly tumor-free subjects.
Carcinoma
Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer.
Carcinoma
Comparison of cytochrome P450- and peroxidase-dependent metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in human cell lines: formation of stable DNA adducts and absence of a detectable increase in apurinic sites.
Carcinoma
Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility.
Carcinoma
Cumulative Evidence for Associations between Genetic Variants and Risk of Esophageal Cancer.
Carcinoma
Cyclin D1, glutathione S-transferase, and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: assessment of the importance of individual genes using multivariate analysis.
Carcinoma
CYP1 and AhR expression in 7,12-dimethylbenz[a]anthracene-induced mammary carcinoma of rats prenatally exposed to 3,3',4,4',5-pentachlorobiphenyl.
Carcinoma
CYP1A1 and CYP2D6 polymorphism and risk of lung cancer in a North Indian population.
Carcinoma
CYP1A1 and CYP2E1 genotypes and risk of esophageal squamous cell carcinoma in a high-incidence region, Kashmir.
Carcinoma
CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro, Brazil.
Carcinoma
CYP1A1 and GSTM1 polymorphisms and oral cancer risk: association studies via evidence-based meta-analyses.
Carcinoma
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung.
Carcinoma
CYP1A1 MspI Polymorphism and Cervical Carcinoma Risk in the Multi-Ethnic Population of Malaysia: a Case-Control Study.
Carcinoma
CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta-analysis.
Carcinoma
CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell carcinoma.
Carcinoma
CYP1A1, CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus.
Carcinoma
CYP1A1, GSTM1 and GSTT1 polymorphisms, tobacco and alcohol status and risk of head and neck squamous cell carcinoma.
Carcinoma
CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: study of population from a high- incidence area in north China.
Carcinoma
CYP1a1, HSP70, P53, and c-fos expression in human liver carcinoma cells (HepG2) exposed to pentachlorophenol.
Carcinoma
CYP1A2 164 A-->C polymorphism, cigarette smoking, consumption of well-done red meat and risk of developing colorectal adenomas and carcinomas.
Carcinoma
CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population.
Carcinoma
CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma.
Carcinoma
CYP2A6 overexpression in human lung cancers correlates with a high malignant status.
Carcinoma
CYP2C9 inhibits the invasion and migration of esophageal squamous cell carcinoma via downregulation of HDAC.
Carcinoma
CYP2D6 gene polymorphism in caucasian smokers: lung cancer susceptibility and phenotype-genotype relationships.
Carcinoma
CYP2E1 G1532C, NQO1 Pro187Ser, and CYP1B1 Val432Leu polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck.
Carcinoma
CYP3A5 and ABCB1 polymorphisms as predictors for sunitinib outcome in metastatic renal cell carcinoma.
Carcinoma
Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer.
Carcinoma
Cytochrome P450 1A1 expression and activity in Caco-2 cells: modulation by apple juice extract and certain apple polyphenols.
Carcinoma
Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis including 1,515 cases and 2,233 controls.
Carcinoma
Cytochrome P450 1B1 polymorphism drives cancer cell stemness and patient outcome in head-and-neck carcinoma.
Carcinoma
Cytochrome P450 2E1 and head and neck cancer: Interaction with genetic and environmental risk factors.
Carcinoma
Cytochrome P450 2E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation.
Carcinoma
Cytochrome P450 expression and activities in human tongue cells and their modulation by green tea extract.
Carcinoma
Cytochrome P450 isoenzyme mRNA expression pattern in human urinary bladder malignancies and normal urothelium.
Carcinoma
Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma.
Carcinoma
Deregulation of signaling pathways controlling cell survival and proliferation in cancer cells alters induction of cytochrome P450 family 1 enzymes.
Carcinoma
Dietary ellagic acid inhibits the enzymatic activity of CYP1A1 without altering hepatic concentrations of CYP1A1 or CYP1A1 mRNA.
Carcinoma
Differential induction of CYP1A1 and CYP1B1 by benzo[a]pyrene in oral squamous cell carcinoma cell lines and by tobacco smoking in oral mucosa.
Carcinoma
Differentiation-dependent induction of CYP1A1 in cultured rat small intestinal epithelial cells, colonocytes, and human colon carcinoma cells: basement membrane-mediated apoptosis.
Carcinoma
Diminished CYP2E1 expression and formation of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1,1-dichloroethylene epoxide, in murine lung tumors.
Carcinoma
Does CYP2E1 RsaI/PstI polymorphism confer head and neck carcinoma susceptibility?: A meta-analysis based on 43 studies.
Carcinoma
Downregulation of the cytochrome P450 4B1 protein confers a poor prognostic factor in patients with urothelial carcinomas of upper urinary tracts and urinary bladder.
Carcinoma
Dual-color fluorescence imaging to monitor CYP3A4 and CYP3A7 expression in human hepatic carcinoma HepG2 and HepaRG cells.
Carcinoma
Effect of Genetic Polymorphisms and Long-Term Tobacco Exposure on the Risk of Breast Cancer.
Carcinoma
Effect of the CYP3A5 and ABCB1 genotype on exposure, clinical response and manifestation of toxicities from sunitinib in Asian patients.
Carcinoma
Effects of herbal medicinal products and food supplements on induction of CYP1A2, CYP3A4 and MDR1 in the human colon carcinoma cell line LS180.
Carcinoma
Epigenetic and genetic dissections of UV-induced global gene dysregulation in skin cells through multi-omics analyses.
Carcinoma
Epigenetic determinants of CYP1A1 induction by the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB 126).
Carcinoma
Evaluation of CYP1B1 Expression, Oxidative Stress and Phase 2 Detoxification Enzyme Status in Oral Squamous Cell Carcinoma Patients.
Carcinoma
Expression alterations of cytochromes P4501A1, 2E1, and 3A, and their receptors AhR and PXR caused by 1-octyl-3-methylimidazolium chloride in mouse mammary carcinoma cells.
Carcinoma
Expression and activity of vitamin D-metabolizing cytochrome P450s (CYP1alpha and CYP24) in human nonsmall cell lung carcinomas.
Carcinoma
Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis.
Carcinoma
Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium.
Carcinoma
Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas.
Carcinoma
Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells.
Carcinoma
Expression of CYP1C1 and CYP1A in Fundulus heteroclitus during PAH-induced carcinogenesis.
Carcinoma
Expression of cytochrome P450s and glutathione S-transferases in human esophagus with squamous-cell carcinomas.
Carcinoma
Expression of enzyme associated with steroid hormone synthesis and local production of steroid hormone in endometrial carcinoma cells.
Carcinoma
Expression of Genes for Methylxanthine Pathway-Associated Enzymes Accompanied by Sex Steroid Receptor Status Impacts Breast Carcinoma Progression.
Carcinoma
Expression profiling of CYP1B1 in oral squamous cell carcinoma: counterintuitive downregulation in tumors.
Carcinoma
Expressions of cytochrome P450, UDP-glucuronosyltranferase, and transporter genes in monolayer carcinoma cells change in subcutaneous tumors grown as xenografts in immunodeficient nude mice.
Carcinoma
Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures.
Carcinoma
Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population.
Carcinoma
Gene expression profiling of cultured human bronchial epithelial and lung carcinoma cells.
Carcinoma
Gene-environment interaction: the role of SULT1A1 and CYP3A5 polymorphisms as risk modifiers for squamous cell carcinoma of the oesophagus.
Carcinoma
Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
Carcinoma
Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk.
Carcinoma
Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use.
Carcinoma
Genetic polymorphism of xenobiotic metabolising enzymes in Slovenian lung cancer patients.
Carcinoma
Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review).
Carcinoma
Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population.
Carcinoma
Genetic polymorphisms in Cytochrome P4501B1 and susceptibility to Head and Neck Cancer.
Carcinoma
Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males.
Carcinoma
Genetic polymorphisms in the Cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx.
Carcinoma
Genetic Polymorphisms of ADH1C and CYP2E1 and Risk of Oral Squamous Cell Carcinoma.
Carcinoma
Genetic polymorphisms of cytochrome p450 2E1, glutathione S-transferase M1 and T1, and susceptibility to gastric carcinoma in Taiwan.
Carcinoma
Genetic polymorphisms of cytochrome P4501A1 and oesophageal squamous-cell carcinoma in Taiwan.
Carcinoma
Genetic polymorphisms of estrogen receptor alpha, CYP19, catechol-O-methyltransferase are associated with familial prostate carcinoma risk in a Japanese population.
Carcinoma
Genetic polymorphisms of metabolic enzymes-CYP1A1, CYP2D6, GSTM1, and GSTT1, and gastric carcinoma susceptibility.
Carcinoma
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility.
Carcinoma
Genetic variants in CYP and GST genes, smoking and risk for head and neck cancers: a gene-environment interaction hospital-based case-control study among Canadian Caucasians.
Carcinoma
Genetically high susceptibility to oral squamous cell carcinoma in terms of combined genotyping of CYP1A1 and GSTM1 genes.
Carcinoma
Genotyping of the CYP1A1 and GSTM1 genes in esophageal carcinoma patients with special reference to smoking.
Carcinoma
Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma.
Carcinoma
Glutathione S-transferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions.
Carcinoma
GST M1 and CYP1A1 gene polymorphism and daily fruit consumption in Turkish patients with non-small cell lung carcinomas.
Carcinoma
GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms in lung cancer patients from an environmentally polluted region of Poland: correlation with lung DNA adduct levels.
Carcinoma
GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma.
Carcinoma
GSTT1, GSTM1, and CYP1B1 gene polymorphisms and susceptibility to sporadic renal cell cancer.
Carcinoma
Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.
Carcinoma
Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation.
Carcinoma
Identification and characterization of genes associated with human hepatocellular carcinogenesis.
Carcinoma
Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b5 Activity.
Carcinoma
Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1.
Carcinoma
Immunohistochemical detection of CYP2E1 and 2-S-glutathionyl acetate in murine lung tumors: diminished formation of reactive intermediates of 1,1-dichloroethylene.
Carcinoma
Immunohistochemical localization of aromatase and apoptosis-associated proteins in ovarian serous cystadenocarcinoma arising from ovarian endometriosis.
Carcinoma
Immunohistochemical localization of cytochrome P450 2E1 in human pulmonary carcinoma and normal bronchial tissue.
Carcinoma
Immunohistochemical localization of cytochrome P450 3A in human pulmonary carcinomas and normal bronchial tissue.
Carcinoma
Impact of body size on first-line Helicobacter pylori eradication success using vonoprazan and amoxicillin dual therapy.
Carcinoma
Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China.
Carcinoma
Important role of CYP2J2 in protein kinase inhibitor degradation: a possible role in intratumor drug disposition and resistance.
Carcinoma
In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles.
Carcinoma
Increased cytochrome P450 and aryl hydrocarbon receptor in bronchial epithelium of heavy smokers with non-small cell lung carcinoma carries a poor prognosis.
Carcinoma
Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer.
Carcinoma
Induction of cytochrome P450 1A1 in human hepatoma HepG2 cells by 6-nitrochrysene.
Carcinoma
Induction of cytochromes P450 1A1 and 1B1 in human lung adenocarcinoma CL5 cells by frying-meat emission particulate.
Carcinoma
Influence of CYP1A1, GSTM1, GSTT1, and NQO1 genotypes and cumulative smoking dose on lung cancer risk in a Swedish population.
Carcinoma
Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome.
Carcinoma
Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol.
Carcinoma
Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists.
Carcinoma
Inhibition of human cytochrome p450 1b1 further clarifies its role in the activation of dibenzo[a,l]pyrene in cells in culture.
Carcinoma
Interaction of cytochrome P4501A1 genotypes with other risk factors and susceptibility to lung cancer.
Carcinoma
Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response.
Carcinoma
Involvement of CYP1B1 in interferon ?-induced alterations of epithelial barrier integrity.
Carcinoma
Isolation and spontaneous transformation of cloned lines of hamster tracheal epithelial cells.
Carcinoma
Lack of association among polymorphic xenobiotic-metabolizing enzyme genotypes and the occurrence and progression of oral carcinoma in a Brazilian population.
Carcinoma
Leu432Val Polymorphism of CYP1B1 is Not Associated with Squamous Cell Carcinoma of Esophagus--a Case-Control Study from Kashmir, India.
Carcinoma
Loss of miR-200c up-regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma.
Carcinoma
Meta-analyses of the effect of CYP1A1 and CYP2D6 polymorphisms on the risk of head and neck squamous cell carcinoma.
Carcinoma
Meta-analysis of association studies of CYP1A1 genetic polymorphisms with digestive tract cancer susceptibility in Chinese.
Carcinoma
Metabolic activation of heterocyclic amines and expression of CYP1A1 in the tongue.
Carcinoma
miR?543 acts as a novel oncogene in oral squamous cell carcinoma by targeting CYP3A5.
Carcinoma
Monooxygenase system in Guerins carcinoma of rats under conditions of ?-3 polyunsaturated fatty acids administration.
Carcinoma
Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual.
Carcinoma
Overexpression of cytochrome P450 1B1 in advanced non-small cell lung cancer: a potential therapeutic target.
Carcinoma
p53 gene mutations, and CYP1A1 and GSTM1 genotypes in pulmonary squamous cell carcinomas.
Carcinoma
p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines.
Carcinoma
p53, but not p16 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use.
Carcinoma
Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.
Carcinoma
Polimorfismos en los genes de la enzima alcohol deshidrogenasa (ADH1) y la citocromo P450 2E1 (CYP2E1) en pacientes con cirrosis y carcinoma hepatocelular.
Carcinoma
Polymorphic variation of Cyp1A1 is associated with the risk of gastric cardia cancer: a prospective case-cohort study of cytochrome P-450 1A1 and GST enzymes.
Carcinoma
Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma.
Carcinoma
Polymorphism in cytochrome P450 1A2 and their interaction with risk factors in determining risk of squamous cell lung carcinoma in men.
Carcinoma
Polymorphism in cytochrome P450 2A6 and glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome.
Carcinoma
Polymorphism in cytochrome P4501A1 is significantly associated with head and neck cancer risk.
Carcinoma
Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients.
Carcinoma
Polymorphisms and haplotypes of TLR4, TLR9 and CYP1A1 genes possibly interfere with high-risk human papillomavirus infection and cervical cancer susceptibility in Jharkhand, India.
Carcinoma
Polymorphisms in drug-metabolizing enzymes and risk to head and neck cancer: evidence for gene-gene and gene-environment interaction.
Carcinoma
Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe.
Carcinoma
Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses.
Carcinoma
Polymorphisms of the CYP1A1 and CYP2E1 genes in head and neck squamous cell carcinoma risk.
Carcinoma
Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population.
Carcinoma
Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose.
Carcinoma
Polymorphisms of the CYP1A1 and GSTM1 genes in relation to individual susceptibility to lung carcinoma in Chinese population.
Carcinoma
Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: impact on DNA adduct formation and prevention by polyphenols.
Carcinoma
Prenatal 3,3',4,4',5-pentachlorobiphenyl exposure modulates induction of rat hepatic CYP 1A1, 1B1, and AhR by 7,12-dimethylbenz[a]anthracene.
Carcinoma
Presentation with multiple cutaneous basal cell carcinomas: association of glutathione S-transferase and cytochrome P450 genotypes with clinical phenotype.
Carcinoma
Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells.
Carcinoma
Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways.
Carcinoma
Protein expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 in young patients with oral squamous cell carcinoma.
Carcinoma
PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides.
Carcinoma
Quantitative assessment of the influence of CYP1B1 polymorphisms and head and neck squamous cell carcinoma risk.
Carcinoma
Quercetin suppresses cytochrome P450 mediated ROS generation and NF?B activation to inhibit the development of 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinomas.
Carcinoma
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.
Carcinoma
Relevance of CYP3A5 Expression on the Clinical Outcome of Patients With Renal Cell Carcinoma.
Carcinoma
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Carcinoma
Risk of renal cell carcinoma and polymorphism in phase I xenobiotic metabolizing CYP1A1 and CYP2D6 enzymes.
Carcinoma
Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population.
Carcinoma
Role of the N-acetyltransferase 2 detoxification system in thyroid cancer susceptibility.
Carcinoma
Screening and analysis of pathogenic genes during DMBA-induced buccal mucosa carcinogenesis in golden hamsters.
Carcinoma
Selective Antitumor Effect of Shikonin Derived DMAKO-20 on Melanoma through CYP1B1.
Carcinoma
Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer.
Carcinoma
Study the polymorphism of CYP3A5 and CYP3A4 loci in Iranian population with laryngeal squamous cell carcinoma.
Carcinoma
Superoxide dismutase and cytochrome P450 isoenzymes might be associated with higher risk of renal cell carcinoma in male patients.
Carcinoma
Suppression of aryl hydrocarbon hydroxylase activity in human primary lung carcinoma x mouse hepatoma somatic cell hybrids.
Carcinoma
Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator.
Carcinoma
Synergistic association of CYP1A1 polymorphisms with increased susceptibility to squamous cell lung cancer in north Indian smokers.
Carcinoma
Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue.
Carcinoma
Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potential.
Carcinoma
Taxifolin Inhibits 7,12-Dimethylbenz(a)anthracene-induced Breast Carcinogenesis by Regulating AhR/CYP1A1 Signaling Pathway.
Carcinoma
The ovarian carcinoma risk with the polymorphisms of CYP1B1 come from the positive selection.
Carcinoma
The steroid hormone dehydroepiandrosterone inhibits CYP1A1 expression in vitro by a post-transcriptional mechanism.
Carcinoma
Tobacco carcinogen-metabolizing genes CYP1A1, GSTM1, and GSTT1 polymorphisms and their interaction with tobacco exposure influence the risk of head and neck cancer in Northeast Indian population.
Carcinoma
Transcriptomic analysis of an in vitro murine model of ovarian carcinoma: Functional similarity to the human disease and identification of prospective tumoral markers and targets.
Carcinoma
Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction.
Carcinoma
Using a combination of cytochrome P450 1B1 and beta-catenin for early diagnosis and prevention of colorectal cancer.
Carcinoma
Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines.
Carcinoma
[Effect of low doses of x-ray irradiation on the liver detoxication system in rats with transplanted Guerin's carcinoma].
Carcinoma
[First results on the influence of polymorphisms at glutathione S-transferase, cytochrome P450, and tumor necrosis factor gene loci on the development of multiple head and neck cancer]
Carcinoma
[Genetic polymorphism of cytochrome P4501A1 and susceptibility to laryngeal carcinoma]
Carcinoma
[Influence of glutathione s-transferase and cytochrome p450 polymorphisms on prognosis of head and neck cancer]
Carcinoma
[Initial results of glutathione-S-transferase GSTM1 and GSTT1 genotypes and genetic predisposition for laryngeal carcinoma]
Carcinoma
[Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma]
Carcinoma
[Smoking and induction of the enzyme aryl hydrocarbon hydroxylase in patients with laryngeal carcinomas and precancerous conditions]
Carcinoma
[Studies of the genes related to lung cancer susceptibility in Nanjing Han population, China.]
Carcinoma
[Study on the Difference of Gene Expression between Central and Peripheral Lung Squamous Cell Carcinoma Based on TCGA Database].
Carcinoma
[The induction of Guerin's carcinoma cytochrome p450 hydroxylase activity by retinoids].
Carcinoma in Situ
Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis.
Carcinoma in Situ
Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium.
Carcinoma, Basal Cell
Association of NAD(P)H:quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci.
Carcinoma, Basal Cell
Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome.
Carcinoma, Basal Cell
Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual.
Carcinoma, Basal Cell
Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma.
Carcinoma, Basal Cell
Presentation with multiple cutaneous basal cell carcinomas: association of glutathione S-transferase and cytochrome P450 genotypes with clinical phenotype.
Carcinoma, Basal Cell
Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction.
Carcinoma, Bronchogenic
Aryl hydrocarbon hydroxylase and bronchogenic carcinomas associated with smoking.
Carcinoma, Bronchogenic
Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma.
Carcinoma, Bronchogenic
Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP.
Carcinoma, Bronchogenic
Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells.
Carcinoma, Bronchogenic
Phase II study of 4-ipomeanol, a naturally occurring alkylating furan, in patients with advanced hepatocellular carcinoma.
Carcinoma, Bronchogenic
The effect of cigarette smoke on aryl hydrocarbon hydroxylase activity and cytochrome P450 content in rat liver and lung microsomes.
Carcinoma, Ductal
7-ethoxyresorufin O-deethylase (EROD) activity is not capable of reflecting the overall malignant potential of breast cancer tissue.
Carcinoma, Ductal
Characterization of cytochrome P450 enzymes in human breast tissue from reduction mammaplasties.
Carcinoma, Ductal
CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma.
Carcinoma, Ductal
Immunohistochemical demonstration of the expression of CYP2E1 in human breast tumour and non-tumour tissues.
Carcinoma, Ductal, Breast
GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer.
Carcinoma, Embryonal
Expression of the mouse P(1)450 gene during differentiation without foreign chemical stimulation.
Carcinoma, Endometrioid
Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma.
Carcinoma, Hepatocellular
2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
Carcinoma, Hepatocellular
2,3,7,8-Tetrachlorodibenzo-p-dioxin receptors regulate transcription of the cytochrome P1-450 gene.
Carcinoma, Hepatocellular
2-(4'-chlorophenyl)benzothiazole is a potent inducer of cytochrome P450IA1 in a human and a mouse cell line. Anomalous correlation between protein and mRNA induction.
Carcinoma, Hepatocellular
2-Phenylphenanthridinone and related compounds: aryl hydrocarbon receptor agonists and suicide inactivators of P4501A1.
Carcinoma, Hepatocellular
A CAR-responsive enhancer element locating approximately 31 kb upstream in the 5'-flanking region of rat cytochrome P450 (CYP) 3A1 gene.
Carcinoma, Hepatocellular
A fish hepatoma cell line (PLHC-1) as a tool to study cytotoxicity and CYP1A induction properties of cellulose and wood chip extracts.
Carcinoma, Hepatocellular
A genetic analysis of processes regulating cytochrome P4501A1 expression.
Carcinoma, Hepatocellular
A Link between cholesterol levels and phenobarbital induction of cytochromes P450.
Carcinoma, Hepatocellular
A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides.
Carcinoma, Hepatocellular
A silent mutation (2939G>A, exon 6; CYP2D6*59) leading to impaired expression and function of CYP2D6.
Carcinoma, Hepatocellular
A soluble NH(2)-terminally truncated catalytically active form of rat cytochrome P450 2E1 targeted to liver mitochondria(1).
Carcinoma, Hepatocellular
A technical mixture of 2,2',4,4'-tetrabromo diphenyl ether (BDE47) and brominated furans triggers aryl hydrocarbon receptor (AhR) mediated gene expression and toxicity.
Carcinoma, Hepatocellular
Aberrant CYP1A1 induction: discrepancy of CYP1A1 mRNA and aryl hydrocarbon hydroxylase activity in mutant cells of mouse hepatoma line, Hepa-1.
Carcinoma, Hepatocellular
Activation function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1.
Carcinoma, Hepatocellular
Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2).
Carcinoma, Hepatocellular
Ah receptor mediating induction of aryl hydrocarbon hydroxylase: detection in human lung by binding of 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin.
Carcinoma, Hepatocellular
AhR regulates the expression of human cytochrome P450 1A1 (CYP1A1) by recruiting Sp1.
Carcinoma, Hepatocellular
Alcohol-and-HIV-Induced Lysosomal Dysfunction Regulates Extracellular Vesicles Secretion in Vitro and in Liver-Humanized Mice.
Carcinoma, Hepatocellular
All-trans retinoic acid inhibits the recruitment of ARNT to DNA, resulting in the decrease of CYP1A1 mRNA expression in HepG2 cells.
Carcinoma, Hepatocellular
Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers.
Carcinoma, Hepatocellular
alpha-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation.
Carcinoma, Hepatocellular
AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.
Carcinoma, Hepatocellular
An autoregulatory loop controlling CYP1A1 gene expression: role of H(2)O(2) and NFI.
Carcinoma, Hepatocellular
Analysis of Ah gene locus by somatic cell hybridization: expression of Ah regulatory gene product for 2,3,7,8,-tetrachlorodibenzo-p-dioxin in mouse L-cell x mouse hepatoma cell hybrids.
Carcinoma, Hepatocellular
Antagonistic and agonistic effects of indigoids on the transformation of an aryl hydrocarbon receptor.
Carcinoma, Hepatocellular
Anticarcinogenic effect of brucine in diethylnitrosamine initiated and phenobarbital-promoted hepatocarcinogenesis in rats.
Carcinoma, Hepatocellular
Anticholestatic effects of bezafibrate in patients with primary biliary cirrhosis treated with ursodeoxycholic acid.
Carcinoma, Hepatocellular
Antigenic stimulation with cytochrome P450 2J expressed in mouse hepatocellular carcinoma cells regulates host anti-tumour immunity.
Carcinoma, Hepatocellular
Application of Statistical Experimental Design and Multivariate Data Analysis for Evaluation of Mixtures using Cytochrome P4501A Induction.
Carcinoma, Hepatocellular
Applications of the in vitro aryl hydrocarbon hydroxylase induction assay for determining "2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents": pyrolyzed brominated flame retardants.
Carcinoma, Hepatocellular
Arecoline inhibits the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 1A1 activation in human hepatoma cells.
Carcinoma, Hepatocellular
Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity.
Carcinoma, Hepatocellular
Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Carcinoma, Hepatocellular
Arsenic inhibits induction of cytochrome P450 1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatoma cells.
Carcinoma, Hepatocellular
Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. IV. Stimulation of the enzyme activity in established cell lines derived from rat or mouse hepatoma and from normal rat liver.
Carcinoma, Hepatocellular
Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Effects of various metabolic inhibitors on the enzyme activity in hepatoma cells.
Carcinoma, Hepatocellular
Aryl hydrocarbon receptor activation and cytochrome P450 1A induction by the mitogen-activated protein kinase inhibitor U0126 in hepatocytes.
Carcinoma, Hepatocellular
Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells.
Carcinoma, Hepatocellular
Assessment of Gold Nanoparticles-Inhibited Cytochrome P450 3A4 Activity and Molecular Mechanisms Underlying Its Cellular Toxicity in Human Hepatocellular Carcinoma Cell Line C3A.
Carcinoma, Hepatocellular
Association between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis.
Carcinoma, Hepatocellular
Association of CYP1A2 genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a high-risk region of China.
Carcinoma, Hepatocellular
Astaxanthin rich crude extract of Haematococcus pluvialis induces cytochrome P450 1A1 mRNA by activating aryl hydrocarbon receptor in rat hepatoma H4IIE cells
Carcinoma, Hepatocellular
Augmentation of 3-methylcholanthrene-induced bioactivation in the human hepatoma cell line HepG2 by the calcium channel blocker nicardipine.
Carcinoma, Hepatocellular
Basis for the loss of aryl hydrocarbon receptor gene expression in clones of a mouse hepatoma cell line.
Carcinoma, Hepatocellular
Benzo[a]pyrene-dependent activation of transcription factors NF-kappaB and AP-1 related to tumor promotion in hepatoma cell cultures.
Carcinoma, Hepatocellular
Binding of polycyclic aromatic hydrocarbons (PAHs) to teleost aryl hydrocarbon receptors (AHRs).
Carcinoma, Hepatocellular
Binding of polynuclear aromatic hydrocarbons to the rat 4S cytosolic binding protein: structure-activity relationships.
Carcinoma, Hepatocellular
Bioassay for determining 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TEs) in human hepatoma Hepg2 cells.
Carcinoma, Hepatocellular
Biochemical screening of highly toxic aromatic contaminants in river sediment and comparison of sensitivity of biological model systems.
Carcinoma, Hepatocellular
Biochemistry and enzyme induction in MC-29 virus-induced transplantable avian hepatoma.
Carcinoma, Hepatocellular
Biomonitoring of polycyclic aromatic hydrocarbons on hepatocellular carcinoma cell line.
Carcinoma, Hepatocellular
Biotransformation of 17 beta-hydroxy-11 beta-(4-dimethylaminophenyl)17 alpha-1-propynyl-estra-4,9-dien-3-one (RU486) in rat hepatoma variants.
Carcinoma, Hepatocellular
Black tea polyphenols, theaflavins, prevent cellular DNA damage by inhibiting oxidative stress and suppressing cytochrome P450 1A1 in cell cultures.
Carcinoma, Hepatocellular
Blockage of multidrug resistance-associated proteins potentiates the inhibitory effects of arsenic trioxide on CYP1A1 induction by polycyclic aromatic hydrocarbons.
Carcinoma, Hepatocellular
Camel milk modulates the expression of aryl hydrocarbon receptor-regulated genes, Cyp1a1, Nqo1, and Gsta1, in murine hepatoma Hepa 1c1c7 cells.
Carcinoma, Hepatocellular
Camel urine inhibits the cytochrome P450 1a1 gene expression through an AhR-dependent mechanism in Hepa 1c1c7 cell line.
Carcinoma, Hepatocellular
Can hepatoma cell lines be redifferentiated to be used in drug metabolism studies?
Carcinoma, Hepatocellular
Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells.
Carcinoma, Hepatocellular
CCAAT/enhancer-binding protein ? activation by capsaicin contributes to the regulation of CYP1A1 expression, mediated by the aryl hydrocarbon receptor.
Carcinoma, Hepatocellular
CCAAT/enhancer-binding protein alpha (C/EBPalpha) and hepatocyte nuclear factor 4alpha (HNF4alpha) synergistically cooperate with constitutive androstane receptor to transactivate the human cytochrome P450 2B6 (CYP2B6) gene: application to the development of a metabolically competent human hepatic cell model.
Carcinoma, Hepatocellular
Changes of CYP1A1, GST, and ALDH3 enzymes in hepatoma cell lines undergoing enhanced lipid peroxidation.
Carcinoma, Hepatocellular
Characterization of CYP1A1 and CYP1A3 gene expression in rainbow trout (Oncorhynchus mykiss).
Carcinoma, Hepatocellular
Characterization of cytochrome P450 2E1 induction in a rat hepatoma FGC-4 cell model by ethanol.
Carcinoma, Hepatocellular
Characterization of hamster CYP1A1 gene: inducible expression and negative regulation.
Carcinoma, Hepatocellular
Characterization of human CYP1A1/1A2 induction by DNA microarray and alpha-naphthoflavone.
Carcinoma, Hepatocellular
Characterization of the environmental quality of sediments from two estuarine systems based on different in-vitro bioassays.
Carcinoma, Hepatocellular
Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin.
Carcinoma, Hepatocellular
Cis-Nerolidol Induces Endoplasmic Reticulum Stress and Cell Death in Human Hepatocellular Carcinoma Cells through Extensive CYP2C19 and CYP1A2 Oxidation.
Carcinoma, Hepatocellular
Combined chemical and toxicological long-term monitoring for AhR agonists with SPMD-based virtual organisms in drinking water Danjiangkou Reservoir, China.
Carcinoma, Hepatocellular
Commiphora myrrha (Nees) Engl. resin extracts induce phase-I cytochrome P450 2C8, 2C9, 2C19, and 3A4 isoenzyme expressions in human hepatocellular carcinoma (HepG2) cells.
Carcinoma, Hepatocellular
Common genetic variations of the cytochrome P450 1A1 gene and risk of hepatocellular carcinoma in a Chinese population.
Carcinoma, Hepatocellular
Comparative studies on the effects of green tea extracts and individual tea catechins on human CYP1A gene expression.
Carcinoma, Hepatocellular
Comparison of expression of aldehyde dehydrogenase 3 and CYP1A1 in dominant and recessive aryl hydrocarbon hydroxylase-deficient mutant mouse hepatoma cells.
Carcinoma, Hepatocellular
Comparison of mouse and chick embryo liver and hepatoma cell lines as model systems used for enzymological estimation of toxicity potentials of organic pollutants.
Carcinoma, Hepatocellular
Comparison of Paeoniflorin and Albiflorin on Human CYP3A4 and CYP2D6.
Carcinoma, Hepatocellular
Comparison of TCDD and PCB CYP1A induction sensitivities in fresh hepatocytes from human donors, sprague-dawley rats, and rhesus monkeys and HepG2 cells.
Carcinoma, Hepatocellular
Competitive binding to the cytosolic 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor. Effects of structure on the affinities of substituted halogenated biphenyls--a QSAR analysis.
Carcinoma, Hepatocellular
Cooperative regulation of CYP3A5 gene transcription by NF-Y and Sp family members.
Carcinoma, Hepatocellular
Correlation of antimutagenic activity and suppression of CYP1A with the lipophilicity of alkyl gallates and other phenolic compounds.
Carcinoma, Hepatocellular
Correlation of PPM1A Downregulation with CYP3A4 Repression in the Tumor Liver Tissue of Hepatocellular Carcinoma Patients.
Carcinoma, Hepatocellular
CYP1A induction potential and the concentration of priority pollutants in marine sediment samples--in vitro evaluation using the PLHC-1 fish hepatoma cell line.
Carcinoma, Hepatocellular
CYP1A1 and CYP1A2 expression levels are differentially regulated in three-dimensional spheroids of liver cancer cells compared to two-dimensional monolayer cultures.
Carcinoma, Hepatocellular
CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines.
Carcinoma, Hepatocellular
CYP1A1-inducing potency in H4IIE cells and chemical composition of technical mixtures of polychlorinated biphenyls.
Carcinoma, Hepatocellular
CYP1A2 suppresses hepatocellular carcinoma through antagonizing HGF/MET signaling.
Carcinoma, Hepatocellular
CYP2E1 overexpression up-regulates both non-specific delta-aminolevulinate synthase and heme oxygenase-1 in the human hepatoma cell line HLE/2E1.
Carcinoma, Hepatocellular
CYP2E1 PstI/RsaI polymorphism and interaction with alcohol consumption in hepatocellular carcinoma susceptibility: evidence from 1,661 cases and 2,317 controls.
Carcinoma, Hepatocellular
CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling.
Carcinoma, Hepatocellular
CYP3A5 is unlikely to mediate anticancer drug resistance in hepatocellular carcinoma.
Carcinoma, Hepatocellular
CYP450 enzyme-specific enantioselective species-specific response for metalaxyl in in vitro hepatic cells.
Carcinoma, Hepatocellular
Cytochrome P-448 induction restores the propagation of .O2--induced lipid peroxidation in hepatoma microsomes.
Carcinoma, Hepatocellular
Cytochrome P450 (CYP1A) induction and DNA adducts in a rat hepatoma cell line (Fao), exposed to environmentally relevant concentrations of organic compounds, singly and in combinations.
Carcinoma, Hepatocellular
Cytochrome P450 1A1 (CYP1A1) Catalyzes Lipid Peroxidation of Oleic Acid-Induced HepG2 Cells.
Carcinoma, Hepatocellular
Cytochrome P450 1A1 gene regulation by UVB involves crosstalk between the aryl hydrocarbon receptor and nuclear factor kappaB.
Carcinoma, Hepatocellular
Cytochrome P450 1A1 genetic polymorphisms and risk of hepatocellular carcinoma among chronic hepatitis B carriers.
Carcinoma, Hepatocellular
Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells.
Carcinoma, Hepatocellular
Cytochrome P450 1A2 Metabolizes 17?-Estradiol to Suppress Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Cytochrome P450 1A2 overcomes nuclear factor kappa B-mediated sorafenib resistance in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Cytochrome P450 2A6 is associated with macrophage polarization and is a potential biomarker for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Cytochrome P450 2E1 and glutathione S-transferase M1 polymorphisms and susceptibility to hepatocellular carcinoma.
Carcinoma, Hepatocellular
Cytochrome P450 2E1 gene polymorphism and alcohol drinking on the risk of hepatocellular carcinoma: a meta-analysis.
Carcinoma, Hepatocellular
Cytochrome P450 2E1 increases the sensitivity of hepatoma cells to vitamin K2.
Carcinoma, Hepatocellular
Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis.
Carcinoma, Hepatocellular
Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells.
Carcinoma, Hepatocellular
Cytochrome P450 family members are associated with fast-growing hepatocellular carcinoma and patient survival: An integrated analysis of gene expression profiles.
Carcinoma, Hepatocellular
Cytochrome P450 induction by nitrated polycyclic aromatic hydrocarbons, azaarenes, and binary mixtures in fish hepatoma cell line PLHC-1.
Carcinoma, Hepatocellular
Cytochrome P450 isozyme distribution in normal and tumor-bearing hepatic tissue from rainbow trout (Salmo gairdneri).
Carcinoma, Hepatocellular
Cytochrome P4501A1 promotes G1 phase cell cycle progression by controlling aryl hydrocarbon receptor activity.
Carcinoma, Hepatocellular
Cytochrome P4502A6 (CYP2A6) expression in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A.
Carcinoma, Hepatocellular
Cytokine-mediated suppression of cytochrome P450 1A1 in Hepa-1c1c7 cells by pokeweed mitogen.
Carcinoma, Hepatocellular
Cytotoxic effects of benzbromarone and its 1'-hydroxy metabolite in human hepatocarcinoma FLC4 cells cultured on micro-space cell culture plates.
Carcinoma, Hepatocellular
Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells.
Carcinoma, Hepatocellular
Cytotoxicity of hexahelicene and its effect on the aryl hydrocarbon receptor pathway.
Carcinoma, Hepatocellular
Decreased expression of cytochrome P450 2E1 is associated with poor prognosis of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Determination of interleukin-4-responsive region in the human cytochrome P450 2E1 gene promoter.
Carcinoma, Hepatocellular
Development and application of test methods for the detection of dietary constituents which protect against heterocyclic aromatic amines.
Carcinoma, Hepatocellular
Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review.
Carcinoma, Hepatocellular
Dibenzoylmethane modulates aryl hydrocarbon receptor function and expression of cytochromes P50 1A1, 1A2, and 1B1.
Carcinoma, Hepatocellular
Differences in induction by xenobiotics in murine tissues and the Hepa1c1c7 cell line of mRNAs encoding glutathione transferase, quinone reductase, and CYP1A P450s.
Carcinoma, Hepatocellular
Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells.
Carcinoma, Hepatocellular
Differential drug-induced mRNA expression of human CYP3A4 compared to CYP3A5, CYP3A7 and CYP3A43.
Carcinoma, Hepatocellular
Differential effect of arecoline on the endogenous dioxin-responsive cytochrome P450 1A1 and on a stably transfected dioxin-responsive element-driven reporter in human hepatoma cells.
Carcinoma, Hepatocellular
Differential effects of dietary fatty acids on the regulation of CYP2E1 and protein kinase C in human hepatoma HepG2 cells.
Carcinoma, Hepatocellular
Differential effects of mercury, lead and copper on the constitutive and inducible expression of aryl hydrocarbon receptor (AHR)-regulated genes in cultured hepatoma Hepa 1c1c7 cells.
Carcinoma, Hepatocellular
Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs.
Carcinoma, Hepatocellular
Differential expression of cytochrome P4502E1 (CYP2E1) in Morris hepatomas and livers of tumor bearing rats.
Carcinoma, Hepatocellular
Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7.
Carcinoma, Hepatocellular
Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines.
Carcinoma, Hepatocellular
Diflubenzuron, a benzoyl-urea insecticide, is a potent inhibitor of TCDD-induced CYP1A1 expression in HepG2 cells.
Carcinoma, Hepatocellular
Diosmetin induces apoptosis by upregulating p53 via the TGF-? signal pathway in HepG2 hepatoma cells.
Carcinoma, Hepatocellular
Dioxin induces localized, graded changes in chromatin structure: implications for Cyp1A1 gene transcription.
Carcinoma, Hepatocellular
Dioxin suppresses benzo[a]pyrene-induced mutations and DNA adduct formation through cytochrome P450 1A1 induction and (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide inactivation in human hepatoma cells.
Carcinoma, Hepatocellular
Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation.
Carcinoma, Hepatocellular
Disruption of dioxin-inducible phase I and phase II gene expression patterns by cadmium, chromium, and arsenic.
Carcinoma, Hepatocellular
Dissecting the expression landscape of cytochromes P450 in hepatocellular carcinoma: towards novel molecular biomarkers.
Carcinoma, Hepatocellular
DNA binding by the heterodimeric Ah receptor. Relationship to dioxin-induced CYP1A1 transcription in vivo.
Carcinoma, Hepatocellular
DNA binding properties of the Ah receptor in wild-type and variant mouse hepatoma cells.
Carcinoma, Hepatocellular
DNA transfection of a gene repressing aryl hydrocarbon hydroxylase induction.
Carcinoma, Hepatocellular
DNA-mediated restoration of aryl hydrocarbon hydroxylase induction in a mouse hepatoma mutant defective in nuclear translocation of the Ah receptor.
Carcinoma, Hepatocellular
Docosahexaenoic acid induces apoptosis in CYP2E1-containing HepG2 cells by activating the c-Jun N-terminal protein kinase related mitochondrial damage.
Carcinoma, Hepatocellular
Down-regulation of aryl hydrocarbon receptor-regulated genes by tumor necrosis factor-alpha and lipopolysaccharide in murine hepatoma Hepa 1c1c7 cells.
Carcinoma, Hepatocellular
Down-regulation of cytochrome P450 2C8 by 3-methylcholanthrene in human hepatocellular carcinoma cell lines.
Carcinoma, Hepatocellular
Down-regulation of nuclear aryl hydrocarbon receptor DNA-binding and transactivation functions: requirement for a labile or inducible factor.
Carcinoma, Hepatocellular
Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Effect of a negative regulatory element (NRE) on the human CYP1A1 gene expression in breast carcinoma MCF-7 and hepatoma HepG2 cells.
Carcinoma, Hepatocellular
Effect of bixin and norbixin on the expression of cytochrome P450 in HepG2 cell line.
Carcinoma, Hepatocellular
Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells.
Carcinoma, Hepatocellular
Effect of some carcinogenic and non-carcinogenic polycyclic aromatic hydrocarbons on gap junction intercellular communication in hepatoma cell cultures.
Carcinoma, Hepatocellular
Effect of strain differences and tumor presence on microsomal drug metabolism in the guinea pig: brief communication.
Carcinoma, Hepatocellular
Effect of tamoxifen feeding on metabolic activation of tamoxifen by the liver of the rhesus monkey: does liver accumulation of inhibitory metabolites protect from tamoxifen-dependent genotoxicity and cancer?
Carcinoma, Hepatocellular
Effects of aflatoxin B?, fumonisin B? and their mixture on the aryl hydrocarbon receptor and cytochrome P450 1A induction.
Carcinoma, Hepatocellular
Effects of arachidonic acid and indomethacin on sister-chromatid exchange induction by polycyclic aromatic hydrocarbons in mammalian cell lines.
Carcinoma, Hepatocellular
Effects of benzimidazole derivatives on cytochrome P450 1A1 expression in a human hepatoma cell line.
Carcinoma, Hepatocellular
Effects of ethanol, dexamethasone and RU 486 on expression of cytochromes P450 2B, 2E, 3A and glutathione transferase pi in a rat hepatoma cell line (Fao).
Carcinoma, Hepatocellular
Effects of fibrates, anti-inflammatory drugs and antidepressants in the fish hepatoma cell line PLHC-1: cytotoxicity and interactions with cytochrome P450 1A.
Carcinoma, Hepatocellular
Effects of o,p'-DDT on the 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible CYP1A1 expression in murine Hepa-1c1c7 cells.
Carcinoma, Hepatocellular
Effects of structure on binding to the 2,3,7,8-TCDD receptor protein and AHH induction--halogenated biphenyls.
Carcinoma, Hepatocellular
Effects of substituents on the cytosolic receptor-binding avidities and aryl hydrocarbon hydroxylase induction potencies of 7-substituted 2,3-dichlorodibenzo-p-dioxins. A quantitative structure-activity relationship analysis.
Carcinoma, Hepatocellular
Efficient one-step selection of hepatoma cell variants of a variety of phenotypes by use of aflatoxin B1.
Carcinoma, Hepatocellular
Elevated glutathione level does not protect against chronic alcohol mediated apoptosis in recombinant human hepatoma cell line VL-17A over-expressing alcohol metabolizing enzymes - Alcohol dehydrogenase and Cytochrome P450 2E1.
Carcinoma, Hepatocellular
Emodin inhibits the growth of hepatoma cells: finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells.
Carcinoma, Hepatocellular
Enantioselectivity of bunitrolol 4-hydroxylation is reversed by the change of an amino acid residue from valine to methionine at position 374 of cytochrome P450-2D6.
Carcinoma, Hepatocellular
Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes.
Carcinoma, Hepatocellular
Establishment of a human hepatoma cell line, HLE/2E1, suitable for detection of p450 2E1-related cytotoxicity.
Carcinoma, Hepatocellular
Establishment of a p-nitrophenol oxidation-based assay for the analysis of CYP2E1 activity in intact hepatocytes in vitro.
Carcinoma, Hepatocellular
Establishment of cytochrome P450 3A4 and glutathione S-transferase A1-transfected human hepatoma cell line and functional analysis.
Carcinoma, Hepatocellular
Establishment of mouse and rat hepatoma cell clones showing stable expression of rabbit cytochrome P450 IA2.
Carcinoma, Hepatocellular
Estradiol metabolism by complementary deoxyribonucleic acid-expressed human cytochrome P450s.
Carcinoma, Hepatocellular
Ethanol enhances hepatitis C virus replication through lipid metabolism and elevated NADH/NAD+.
Carcinoma, Hepatocellular
Evaluation of a human hepatoma cell line as a target cell in genetic toxicology.
Carcinoma, Hepatocellular
Evaluation of CYP3A4 inhibition and hepatotoxicity using DMSO-treated human hepatoma HuH-7 cells.
Carcinoma, Hepatocellular
Evaluation of genipin on human cytochrome P450 isoenzymes and P-glycoprotein in vitro.
Carcinoma, Hepatocellular
Evidence for the involvement of cytochrome P-450-dependent monooxygenase(s) in the formation of genotoxic metabolites from N-hydroxyurea.
Carcinoma, Hepatocellular
Evidence that 2,3,7,8-tetrachlorodibenzo-p-dioxin induces NADPH cytochrome c (P-450) reductase in rat hepatoma cells in culture.
Carcinoma, Hepatocellular
Expression of cathepsin B and aryl hydrocarbon hydroxylase activities, and of apolipoprotein B in human hepatoma cells maintained long-term in a serum-free medium.
Carcinoma, Hepatocellular
Expression of cytochrome P450 1A1/2 and 3A4 in liver tissues of hepatocellular carcinoma cases and controls from Taiwan and their relationship to hepatitis B virus and aflatoxin B1-and 4-aminobiphenyl-DNA adducts.
Carcinoma, Hepatocellular
Expression of cytochrome P450 in LEC rats during the development of hereditary hepatitis and hepatoma.
Carcinoma, Hepatocellular
Expression of Cytochromes P-450 2E1, 3A4 and 1A1/1A2 in Growing and Confluent Human HepG2 Hepatoma Cells-Effect of Ethanol.
Carcinoma, Hepatocellular
Expression of cytochromes P-450 in rat hepatoma cells. Analysis by monoclonal antibodies specific for cytochromes P-450 from rat liver induced by 3-methylcholanthrene or phenobarbital.
Carcinoma, Hepatocellular
Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells.
Carcinoma, Hepatocellular
Failure of Ah receptor to mediate induction of cytochromes P450 in the CYP1 family in the human hepatoma line SK-Hep-1.
Carcinoma, Hepatocellular
Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.
Carcinoma, Hepatocellular
Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices.
Carcinoma, Hepatocellular
Fucoxanthin Attenuates Rifampin-Induced Cytochrome P450 3A4 (CYP3A4) and Multiple Drug Resistance 1 (MDR1) Gene Expression Through Pregnane X Receptor (PXR)-Mediated Pathways in Human Hepatoma HepG2 and Colon Adenocarcinoma LS174T Cells.
Carcinoma, Hepatocellular
Fumonisin B1 modulates expression of human cytochrome P450 1b1 in human hepatoma (Hepg2) cells by repressing Mir-27b.
Carcinoma, Hepatocellular
Functional activity of human hepatoma cells transfected with adenovirus-mediated hepatocyte nuclear factor (HNF)-4 gene.
Carcinoma, Hepatocellular
Functional alterations of the endoplasmic reticulum and the detoxification systems during diethyl-nitrosamine carcinogenesis in rat liver.
Carcinoma, Hepatocellular
Functional analysis of the human cytochrome P4501A1 (CYP1A1) gene enhancer.
Carcinoma, Hepatocellular
Functional analysis of the transcriptional promoter for the CYP1A1 gene.
Carcinoma, Hepatocellular
General review on in vitro hepatocyte models and their applications.
Carcinoma, Hepatocellular
Genetic analysis of aflatoxin B1 activation in rat hepatoma cells.
Carcinoma, Hepatocellular
Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1.
Carcinoma, Hepatocellular
Genetic polymorphisms of cytochrome P450 in patients with hepatitis C virus-associated hepatocellular carcinoma.
Carcinoma, Hepatocellular
Genetic Polymorphisms of Cytochrome P4501A1 (CYP1A1) and Glutathione S-Transferase P1 (GSTP1) and Risk of Hepatocellular Carcinoma Among Chronic Hepatitis C Patients in Egypt.
Carcinoma, Hepatocellular
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Genetic variants of ALDH2-rs671 and CYP2E1-rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population.
Carcinoma, Hepatocellular
Genistein affects expression of cytochrome P450 (CYP450) genes in hepatocellular carcinoma (HEPG2/C3A) cell line.
Carcinoma, Hepatocellular
Genomic consequences of cytochrome P450 2C9 overexpression in human hepatoma cells.
Carcinoma, Hepatocellular
Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor.
Carcinoma, Hepatocellular
Glucose inhibition of the induction of CYP2E1 mRNA expression by ethanol in FGC-4 cells.
Carcinoma, Hepatocellular
GSH/GSSG redox couple plays central role in aryl hydrocarbon receptor-dependent modulation of cytochrome P450 1A1.
Carcinoma, Hepatocellular
Halogenated biphenyls as AHH inducers: effects of different halogen substituents.
Carcinoma, Hepatocellular
Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms.
Carcinoma, Hepatocellular
HBx inhibits CYP2E1 gene expression via downregulating HNF4? in human hepatoma cells.
Carcinoma, Hepatocellular
Hepa-1 enzyme induction assay as an in vitro indicator of the CYP1A1-inducing potencies of laboratory rodent diets in vivo.
Carcinoma, Hepatocellular
HepaRG cells as human-relevant in vitro model to study the effects of inflammatory stimuli on cytochrome P450 isoenzymes.
Carcinoma, Hepatocellular
Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.
Carcinoma, Hepatocellular
Hepatic CYP1A2 activity in liver tumors and the implications for preoperative volume-function analysis.
Carcinoma, Hepatocellular
Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells.
Carcinoma, Hepatocellular
Hepatocellular carcinoma: gene expression profiling and regulation of xenobiotic-metabolizing cytochromes P450.
Carcinoma, Hepatocellular
High CYP2E1 activity correlates with hepatofibrogenesis induced by nitrosamines.
Carcinoma, Hepatocellular
High expression of cytochrome P450 2a-5 (coumarin 7-hydroxylase) in mouse hepatomas.
Carcinoma, Hepatocellular
Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells.
Carcinoma, Hepatocellular
How the potency of the steroid RU486 is related to P450 activities induced by dexamethasone and phenobarbital in rat hepatoma cells.
Carcinoma, Hepatocellular
Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin.
Carcinoma, Hepatocellular
Human cDNA-expressed cytochrome P450 IA2: mutagen activation and substrate specificity.
Carcinoma, Hepatocellular
Human CYP1B1-dependent genotoxicity of dioxin-like polychlorinated biphenyls in mammalian cells.
Carcinoma, Hepatocellular
Human CYP2E1-activated mutagenicity of dioxin-like PCBs 105 and 118-Experimental data consistent with molecular docking results.
Carcinoma, Hepatocellular
Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes.
Carcinoma, Hepatocellular
Identification and characterization of a mitochondrial targeting signal in rat cytochrome P450 2E1 (CYP2E1).
Carcinoma, Hepatocellular
Identification and characterization of genes associated with human hepatocellular carcinogenesis.
Carcinoma, Hepatocellular
Identification of a cell-specific transcription activation domain within the human Ah receptor nuclear translocator.
Carcinoma, Hepatocellular
Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors.
Carcinoma, Hepatocellular
Identification of oxidized mitochondrial proteins in alcohol-exposed human hepatoma cells and mouse liver.
Carcinoma, Hepatocellular
Identification of the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole, in cell culture medium, as a factor that controls the background aryl hydrocarbon receptor activity.
Carcinoma, Hepatocellular
Identifying hepatocellular carcinoma-related hub genes by bioinformatics analysis and CYP2C8 is a potential prognostic biomarker.
Carcinoma, Hepatocellular
IL-4-mediated transcriptional regulation of human CYP2E1 by two independent signaling pathways.
Carcinoma, Hepatocellular
Immunochemically detected nuclear envelope-associated cytochrome P-450 component(s) in rat hepatocyte culture lines.
Carcinoma, Hepatocellular
Immunohistochemical markers of CYP3A4 and CYP3A7: a new tool towards personalized pharmacotherapy of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Immunohistochemical study of CYP2E1 in hepatocellular carcinoma carcinogenesis: examination with newly prepared anti-human CYP2E1 antibody.
Carcinoma, Hepatocellular
Impact of Alternaria toxins on CYP1A1 expression in different human tumor cells and relevance for genotoxicity.
Carcinoma, Hepatocellular
In silico screening and analysis of nonsynonymous SNPs in human CYP1A2 to assess possible associations with pathogenicity and cancer susceptibility.
Carcinoma, Hepatocellular
In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces amphiregulin gene expression in the developing mouse ureter.
Carcinoma, Hepatocellular
In vitro toxicity and in silico docking analysis of two novel selective AH-receptor modulators.
Carcinoma, Hepatocellular
In vivo/in vitro comparison of the pharmacokinetics and pharmacodynamics of 3,3',4,4'-tetrachlorobiphenyl (PCB77).
Carcinoma, Hepatocellular
Increased cytotoxicity of carbon tetrachloride in a human hepatoma cell line overexpressing cytochrome P450 2E1.
Carcinoma, Hepatocellular
Increased effects of 2,5-dimethylcelecoxib on sensitivity of hepatocellular carcinoma cells to sorafenib via CYP3A5 expression and activation of AMPK.
Carcinoma, Hepatocellular
Increased expression of drug-metabolizing enzymes in human hepatocarcinoma FLC-4 cells cultured on micro-space cell culture plates.
Carcinoma, Hepatocellular
Increased oxidative stress and toxicity in ADH and CYP2E1 overexpressing human hepatoma VL-17A cells exposed to high glucose.
Carcinoma, Hepatocellular
Inducing effects of dioxin-like polychlorinated biphenyls on CYP1A in the human hepatoblastoma cell line HepG2, the rat hepatoma cell line H4IIE, and rat primary hepatocytes: comparison of relative potencies.
Carcinoma, Hepatocellular
Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol.
Carcinoma, Hepatocellular
Induction by phenobarbital in McA-RH7777 rat hepatoma cells of a polycyclic hydrocarbon inducible cytochrome P450.
Carcinoma, Hepatocellular
Induction of aryl hydrocarbon hydroxylase activity in cell cultures by aroclors, residues from yusho oil samples, and polychlorinated biphenyl residues from fish samples.
Carcinoma, Hepatocellular
Induction of aryl hydrocarbon hydroxylase and demonstration of a specific nuclear receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in two human hepatoma cell lines.
Carcinoma, Hepatocellular
Induction of CYP1A1 gene expression in H4-II-E rat hepatoma cells by benzo[e]pyrene.
Carcinoma, Hepatocellular
Induction of CYP1A1 gene expression in mouse hepatoma cells by benzo[e]pyrene, a ligand of the 4S polycyclic hydrocarbon-binding protein.
Carcinoma, Hepatocellular
Induction of cytochrome P-450 1A2 by oxidized tryptophan in Hepa lclc7 cells.
Carcinoma, Hepatocellular
Induction of cytochrome P450 1A1 by ketoconazole and itraconazole but not fluconazole in murine and human hepatoma cell lines.
Carcinoma, Hepatocellular
Induction of cytochrome P450 1A1 gene expression by a vitamin K3 analog in mouse hepatoma Hepa-1c1c7 cells.
Carcinoma, Hepatocellular
Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells.
Carcinoma, Hepatocellular
Induction of cytochrome P450 1A1 in human hepatoma HepG2 cells by 6-nitrochrysene.
Carcinoma, Hepatocellular
Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: mechanistic studies using radiolabeled congeners.
Carcinoma, Hepatocellular
Induction of cytochrome P4501A and endocrine disrupting effects of school incinerator residues.
Carcinoma, Hepatocellular
Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage.
Carcinoma, Hepatocellular
Induction of cytochrome P4501A1 by autoclavable culture medium change in HepG2 cells.
Carcinoma, Hepatocellular
Induction of cytochrome P4501A1 by ozone-oxidized tryptophan in Hepa lclc7 cells.
Carcinoma, Hepatocellular
Induction of cytochrome P450IA1 in mouse hepatoma cells by several chemicals. Phenobarbital and TCDD induce the same form of cytochrome P450.
Carcinoma, Hepatocellular
Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line.
Carcinoma, Hepatocellular
Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5.
Carcinoma, Hepatocellular
Induction of DNA damage by N-nitrosodiethylamine in rat hepatoma cells: correlation with cytochrome P450-mediated aldrin epoxidase activity.
Carcinoma, Hepatocellular
Induction of enzyme activity in cell culture: a rapid screen for detection of planar polychlorinated organic compounds.
Carcinoma, Hepatocellular
Induction of hepatic metabolic functions by a novel variant of hepatocyte nuclear factor 4?.
Carcinoma, Hepatocellular
Induction of zone-like liver function gradients in HepG2 cells by varying culture medium height.
Carcinoma, Hepatocellular
Influence of Mycoplasma arginini infection on the induction of aryl hydrocarbon hydroxylase by TCDD in rat hepatoma cell cultures.
Carcinoma, Hepatocellular
Inhibition of benzo[a]pyrene metabolism by insulin, FITC-insulin and an FITC-insulin-antibody conjugate in the human hepatoma cell line HepG2.
Carcinoma, Hepatocellular
Inhibition of calcitriol inactivating enzyme CYP24A1 gene expression by flavonoids in hepatocellular carcinoma cells under normoxia and hypoxia.
Carcinoma, Hepatocellular
Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.
Carcinoma, Hepatocellular
Inhibition of cytochrome P450 1A1 by antisense phosphorothioate oligonucleotide in Hepa lclc7 cells.
Carcinoma, Hepatocellular
Inhibition of gap junction intercellular communications in cell culture by polycyclic aromatic hydrocarbons (PAH) in the absence of PAH metabolism.
Carcinoma, Hepatocellular
Inhibitory effect of naringenin (citrus flavonone) on N-nitrosodiethylamine induced hepatocarcinogenesis in rats.
Carcinoma, Hepatocellular
Insulin down-regulates cytochrome P450 2B and 2E expression at the post-transcriptional level in the rat hepatoma cell line.
Carcinoma, Hepatocellular
Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population.
Carcinoma, Hepatocellular
Interaction between dose and susceptibility to environmental cancer: a short review.
Carcinoma, Hepatocellular
Interaction of diuron and related substituted phenylureas with the Ah receptor pathway.
Carcinoma, Hepatocellular
Interactions between CYP1A1 polymorphisms and cigarette smoking are associated with the risk of hepatocellular carcinoma: evidence from epidemiological studies.
Carcinoma, Hepatocellular
Interleukin-6 down regulates the expression of transcripts encoding cytochrome P450 IA1, IA2 and IIIA3 in human hepatoma cells.
Carcinoma, Hepatocellular
Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells.
Carcinoma, Hepatocellular
Involvement of aryl hydrocarbon receptor in the cytotoxicity of corannulene and its derivatives.
Carcinoma, Hepatocellular
Involvement of different pathways in the genotoxicity of nitropropanes in cultured mammalian cells.
Carcinoma, Hepatocellular
Involvement of pregnane x receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes.
Carcinoma, Hepatocellular
In vitro profiling of the potential endocrine disrupting activities affecting steroid and aryl hydrocarbon receptors of compounds and mixtures prevalent in human drinking water resources.
Carcinoma, Hepatocellular
Itraconazole cis-diastereoisomers activate aryl hydrocarbon receptor AhR and pregnane X receptor PXR and induce CYP1A1 in human cell lines and human hepatocytes.
Carcinoma, Hepatocellular
Janus kinase-dependent regulation of drug detoxifying protein expression by interleukin-22 in human hepatic cells.
Carcinoma, Hepatocellular
JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes.
Carcinoma, Hepatocellular
Ketoconazole Stereoisomers Differentially Induce Cytochrome P450 1A1 Between Human Hepatoma HepG2 and Mouse Hepatoma Hepa1c1c7 Cells.
Carcinoma, Hepatocellular
Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c1c7.
Carcinoma, Hepatocellular
Lack of association between the functional polymorphisms in the estrogen-metabolizing genes and risk for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Lack of association of cytochrome P450 2E1 genetic polymorphisms with the risk of human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SK-HEP-1 to dioxin.
Carcinoma, Hepatocellular
Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization.
Carcinoma, Hepatocellular
Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies.
Carcinoma, Hepatocellular
Loss of cyp1a1 messenger rna expression due to nonsense-mediated decay.
Carcinoma, Hepatocellular
Marked increase of CYP24A1 mRNA level in hepatocellular carcinoma cell lines following vitamin D administration.
Carcinoma, Hepatocellular
Measurement of Cytochrome P450 Enzyme Induction and Inhibition in Human Hepatoma Cells.
Carcinoma, Hepatocellular
Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: characterization of 6-[125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes.
Carcinoma, Hepatocellular
Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.
Carcinoma, Hepatocellular
Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo.
Carcinoma, Hepatocellular
Mechanism of dioxin action: receptor-enhancer interactions in intact cells.
Carcinoma, Hepatocellular
Mechanism of maintenance of liver-specific functions by DMSO in cultured rat hepatocytes.
Carcinoma, Hepatocellular
Mechanism-based in vitro screening of potential cancer chemopreventive agents.
Carcinoma, Hepatocellular
Mechanisms involved in lipid accumulation and apoptosis induced by 1-nitropyrene in Hepa1c1c7 cells.
Carcinoma, Hepatocellular
Mechanisms of down-regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells.
Carcinoma, Hepatocellular
Mercury modulates the CYP1A1 at transcriptional and posttranslational levels in human hepatoma HepG2 cells.
Carcinoma, Hepatocellular
Metabolic activation of the potent carcinogen dibenzo[a,h]anthracene by cDNA-expressed human cytochromes P450.
Carcinoma, Hepatocellular
Metabolic characteristics and enflurane defluorination of cytochrome P450-dependent monooxygenases in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Metabolic enzyme induction by HepG2 cells exposed to oxygenated and nonoxygenated polycyclic aromatic hydrocarbons.
Carcinoma, Hepatocellular
Metabolic Susceptibility of 2-Chlorothioxanthone and Its Toxic Effects on mRNA and Protein Expression and Activities of Human CYP1A2 and CYP3A4 Enzymes.
Carcinoma, Hepatocellular
Metabolism-based polycyclic aromatic acetylene inhibition of CYP1B1 in 10T1/2 cells potentiates aryl hydrocarbon receptor activity.
Carcinoma, Hepatocellular
Methodological remarks concerning the recent meta-analysis on CYP1A1 polymorphisms-smoking interaction and hepatocellular carcinoma risk.
Carcinoma, Hepatocellular
Methoxychlor suppresses the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible CYP1A1 expression in murine Hepa-1c1c7 cells.
Carcinoma, Hepatocellular
Metoronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes.
Carcinoma, Hepatocellular
MG-132 inhibits the TCDD-mediated induction of Cyp1a1 at the catalytic activity but not the mRNA or protein levels in Hepa 1c1c7 cells.
Carcinoma, Hepatocellular
Microfluidic geometric metering-based multi-reagent mixture generator for robust live cell screening array.
Carcinoma, Hepatocellular
Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats.
Carcinoma, Hepatocellular
Mixture effects between different azoles and ?-naphthoflavone on the CYP1A biomarker in a fish cell line.
Carcinoma, Hepatocellular
Modulation of aryl hydrocarbon receptor-regulated gene expression by arsenite, cadmium, and chromium.
Carcinoma, Hepatocellular
Modulation of aryl hydrocarbon receptor-regulated genes by acute administration of ammonium metavanadate in kidney, lung and heart of C57BL/6 mice.
Carcinoma, Hepatocellular
Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation.
Carcinoma, Hepatocellular
Modulation of carcinogen metabolizing enzymes by chromanone A; a new chromone derivative from algicolous marine fungus Penicillium sp.
Carcinoma, Hepatocellular
Modulation of cytochrome P4501-mediated bioactivation of benzo[a]pyrene by volatile allyl sulfides in human hepatoma cells.
Carcinoma, Hepatocellular
Modulation of cytochrome P4501A1 activity by ascorbigen in murine hepatoma cells.
Carcinoma, Hepatocellular
Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.
Carcinoma, Hepatocellular
Modulation of TCDD-mediated induction of cytochrome P450 1A1 by mercury, lead, and copper in human HepG2 cell line.
Carcinoma, Hepatocellular
Molecular basis for the transport of cytochrome P450 2E1 to the plasma membrane.
Carcinoma, Hepatocellular
Molecular basis of severe gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma.
Carcinoma, Hepatocellular
Molecular Links between Alcohol and Tobacco Induced DNA Damage, Gene Polymorphisms and Patho-physiological Consequences: A Systematic Review of Hepatic Carcinogenesis.
Carcinoma, Hepatocellular
Mouse dioxin-inducible cytosolic aldehyde dehydrogenase-3: AHD4 cDNA sequence, genetic mapping, and differences in mRNA levels.
Carcinoma, Hepatocellular
Mouse dioxin-inducible NAD(P)H: menadione oxidoreductase: NMO1 cDNA sequence and genetic differences in mRNA levels.
Carcinoma, Hepatocellular
MRNA levels of two different enzymes in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Multiparametric characterization by flow cytometry of flow-sorted subpopulations of a human hepatoma cell line useful for drug research.
Carcinoma, Hepatocellular
Multivariate modelling of polychlorinated biphenyl-induced CYP1A activity in the MH1C1 rat hepatoma cell line.
Carcinoma, Hepatocellular
Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline by complementary DNA-expressed human liver P-450.
Carcinoma, Hepatocellular
N-Hydroxylation of 4-Aminobiphenyl by CYP2E1 Produces Oxidative Stress in a Mouse Model of Chemically Induced Liver Cancer.
Carcinoma, Hepatocellular
Natural furocoumarins as inducers and inhibitors of cytochrome P450 1A1 in rat hepatocytes.
Carcinoma, Hepatocellular
Nicotine stimulates CYP1A1 expression in human hepatocellular carcinoma cells via AP-1, NF-?B, and AhR.
Carcinoma, Hepatocellular
Nitric oxide and interleukin-1? stimulate the proteasome-independent degradation of the retinoic acid hydroxylase CYP2C22 in primary rat hepatocytes.
Carcinoma, Hepatocellular
Nitric Oxide Mediated Degradation of CYP2A6 via the Ubiquitin-Proteasome Pathway in Human Hepatoma Cells.
Carcinoma, Hepatocellular
No role of protected region B of human cytochrome P4501A2 gene (CYP1A2) as an AP-1 response element.
Carcinoma, Hepatocellular
Novel transcriptional regulation of the human CYP3A7 gene by Sp1 and Sp3 through nuclear factor kappa B-like element.
Carcinoma, Hepatocellular
Nuclear transcription factor Oct-1 binds to the 5'-upstream region of CYP1A1 and negatively regulates its expression.
Carcinoma, Hepatocellular
Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: transcriptional activation of the human CYP1A1 gene.
Carcinoma, Hepatocellular
Occurrence of PCDD/PCDFs and PCBs in soil and comparison with CYP1A response in PLHC-1 cell line.
Carcinoma, Hepatocellular
Oct-1 transcription factor is a negative regulator of rat CYP1A1 expression via an octamer sequence in its negative regulatory element.
Carcinoma, Hepatocellular
Omeprazole alleviates benzo[a]pyrene cytotoxicity by inhibition of CYP1A1 activity in human and mouse hepatoma cells.
Carcinoma, Hepatocellular
Omeprazole transactivates human CYP1A1 and CYP1A2 expression through the common regulatory region containing multiple xenobiotic-responsive elements.
Carcinoma, Hepatocellular
Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus.
Carcinoma, Hepatocellular
Overexpression of CYP2E1 enhances sensitivity of hepG2 cells to fas-mediated cytotoxicity.
Carcinoma, Hepatocellular
Oxidative metabolism of bunitrolol by complementary DNA-expressed human cytochrome P450 isozymes in a human hepatoma cell line (Hep G2) using recombinant vaccinia virus.
Carcinoma, Hepatocellular
p38 Mitogen Activated Protein Kinase Regulates the Nuclear Receptor CAR to Activate the CYP2B6 Gene.
Carcinoma, Hepatocellular
Paclitaxel Nanoparticles Induce Apoptosis and Regulate TXR1, CYP3A4 and CYP2C8 in Breast Cancer and Hepatoma Cells.
Carcinoma, Hepatocellular
Palmatine activates AhR and upregulates CYP1A activity in HepG2 cells but not in human hepatocytes.
Carcinoma, Hepatocellular
Patterns of expression of cytochrome P450 genes in progression of hepatitis C virus-associated hepatocellular carcinoma.
Carcinoma, Hepatocellular
PCB isomers and congeners: induction of aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase enzyme activities in rat hepatoma cells.
Carcinoma, Hepatocellular
Peganum Harmala L. Differentially Modulates Cytochrome P450 Gene Expression in Human Hepatoma HepG2 Cells.
Carcinoma, Hepatocellular
Peganum harmala L. differentially modulates cytochrome P450 gene expression in human hepatoma HepG2 cells.
Carcinoma, Hepatocellular
Persistent induction of cytochrome P4501A1 in human hepatoma cells by 3-methylcholanthrene: evidence for sustained transcriptional activation of the CYP1A1 promoter.
Carcinoma, Hepatocellular
Pharmacokinetic interaction involving sorafenib and the calcium-channel blocker felodipine in a patient with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Phase II study of 4-ipomeanol, a naturally occurring alkylating furan, in patients with advanced hepatocellular carcinoma.
Carcinoma, Hepatocellular
Phenobarbital induces cytochrome P-450- and cytochrome P-448-dependent monooxygenases in rat hepatoma cells.
Carcinoma, Hepatocellular
Phenobarbital stimulation of cytochrome P-450 and aminopyrine N-demethylase in hyperplastic liver nodules during LD-ethionine carcinogenesis.
Carcinoma, Hepatocellular
Phenobarbital, dexamethasone and benzanthracene induce several cytochrome P450 mRNAs in rat hepatoma cells.
Carcinoma, Hepatocellular
Piperine impairs cytochrome P4501A1 activity by direct interaction with the enzyme and not by down regulation of CYP1A1 gene expression in the rat hepatoma 5L cell line.
Carcinoma, Hepatocellular
Plasma caffeine metabolite ratio (17X/137X) in vivo associated with G-2964A and C734A polymorphisms of human CYP1A2.
Carcinoma, Hepatocellular
Polybrominated dibenzo-p-dioxins and related compounds: quantitative in vivo and in vitro structure-activity relationships.
Carcinoma, Hepatocellular
Polychlorinated dibenzo-p-dioxins: quantitative in vitro and in vivo structure-activity relationships.
Carcinoma, Hepatocellular
Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity.
Carcinoma, Hepatocellular
Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells.
Carcinoma, Hepatocellular
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Carcinoma, Hepatocellular
Polymorphisms of the CYP1B1 gene and hepatocellular carcinoma risk in a Chinese population.
Carcinoma, Hepatocellular
Post-translational inhibition of cytochrome P-450 2E1 expression by chlomethiazole in Fao hepatoma cells.
Carcinoma, Hepatocellular
Posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by methylmercury in HepG2 cells: A role of heme oxygenase-1.
Carcinoma, Hepatocellular
Potentiating effect of graphene nanomaterials on aromatic environmental pollutant-induced cytochrome P450 1A expression in the topminnow fish hepatoma cell line PLHC-1.
Carcinoma, Hepatocellular
Probing the control elements of the CYP1A1 switching module in H4IIE hepatoma cells.
Carcinoma, Hepatocellular
Profiling cytochrome P450 family 4 gene expression in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells.
Carcinoma, Hepatocellular
Protein-DNA interactions at a dioxin-responsive enhancer. Analysis of six bona fide DNA-binding sites for the liganded Ah receptor.
Carcinoma, Hepatocellular
Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR.
Carcinoma, Hepatocellular
Pungent ginger components modulates human cytochrome P450 enzymes in vitro.
Carcinoma, Hepatocellular
Purification and characterization of recombinant rat hepatic CYP4F1.
Carcinoma, Hepatocellular
Quantitative structure-activity relationships: analysis of interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2-substituted analogues with rat, mouse, guinea pig, and hamster cytosolic receptor.
Carcinoma, Hepatocellular
Quercetin, Quercetin Glycosides and Taxifolin Differ in their Ability to Induce AhR Activation and CYP1A1 Expression in HepG2 Cells.
Carcinoma, Hepatocellular
Quercetin, Resveratrol, and Curcumin Are Indirect Activators of the Aryl Hydrocarbon Receptor (AHR).
Carcinoma, Hepatocellular
Rabbit cytochrome P450 4B1: A novel prodrug activating gene for pharmacogene therapy of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Rat CYP1A1 negative regulatory element: biological activity and interaction with a protein from liver and hepatoma cells.
Carcinoma, Hepatocellular
Re-expression of C/EBP alpha induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells.
Carcinoma, Hepatocellular
Regulation of CYP1A induction in hepatoma 27 depending on the site of transplantation.
Carcinoma, Hepatocellular
Regulation of CYP1A1 by indolo[3,2-b]carbazole in murine hepatoma cells.
Carcinoma, Hepatocellular
Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone.
Carcinoma, Hepatocellular
Regulation of Cyp1a1 induction by dioxin as a function of cell cycle phase.
Carcinoma, Hepatocellular
Regulation of CYP1A1 transcription via the metabolism of the tryptophan-derived 6-formylindolo[3,2-b]carbazole.
Carcinoma, Hepatocellular
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.
Carcinoma, Hepatocellular
Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction.
Carcinoma, Hepatocellular
Regulation of NAD(P)H:quinone oxidoreductase 1 gene expression by CYP1A1 activity.
Carcinoma, Hepatocellular
Regulation of the CYP1A1 gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin but not by beta-naphthoflavone or 3-methylcholanthrene is altered in hepatitis C virus replicon-expressing cells.
Carcinoma, Hepatocellular
Regulation of [Ah] gene battery enzymes and glutathione levels by 5,10-dihydroindeno[1,2-b]indole in mouse hepatoma cell lines.
Carcinoma, Hepatocellular
Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver.
Carcinoma, Hepatocellular
Regulatory sequence responsible for insulin destabilization of cytochrome P450 2B1 (CYP2B1) mRNA.
Carcinoma, Hepatocellular
Relationship between cytochrome P450 catalytic cycling and stability: fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) in hepatoma cells is abolished by inactivation of its electron donor NADPH-cytochrome P450 reductase.
Carcinoma, Hepatocellular
Relationship of ALDH2 rs671 and CYP2E1 rs2031920 with hepatocellular carcinoma susceptibility in East Asians: a meta-analysis.
Carcinoma, Hepatocellular
Relative Contributions of CYP1A2 and CYP2E1 to the Bioactivation and Clearance of 4-Aminobiphenyl in Adult Mice.
Carcinoma, Hepatocellular
Relative potencies of PAHs and PCBs based on the response of human cells.
Carcinoma, Hepatocellular
Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP).
Carcinoma, Hepatocellular
Restoration of hydroperoxide-dependent lipid peroxidation by 3-methylcholanthrene induction of cytochrome P-448 in hepatoma microsomes.
Carcinoma, Hepatocellular
Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the Aryl Hydrocarbon Receptor complex and RNA Polymerase II to the regulatory regions of the corresponding genes.
Carcinoma, Hepatocellular
Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor.
Carcinoma, Hepatocellular
Role of CYP3A4 in the regulation of the aryl hydrocarbon receptor by omeprazole sulphide.
Carcinoma, Hepatocellular
Role of cytochrome P450 enzyme induction in the metabolic activation of benzo[c]phenanthrene in human cell lines and mouse epidermis.
Carcinoma, Hepatocellular
Role of cytochrome P450 in the control of the production of erythropoietin.
Carcinoma, Hepatocellular
Role of DNA methylation-related chromatin remodeling in aryl hydrocarbon receptor-dependent regulation of T-2 toxin highly inducible Cytochrome P450 1A4 gene.
Carcinoma, Hepatocellular
Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes.
Carcinoma, Hepatocellular
Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator.
Carcinoma, Hepatocellular
Role of nitric oxide in downregulation of cytochrome P450 1a1 and NADPH: Quinone oxidoreductase 1 by tumor necrosis factor-alpha and lipopolysaccharide.
Carcinoma, Hepatocellular
RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Screening of fresh water fish extracts for enzyme-inducing substances by an aryl hydrocarbon hydroxylase induction bioassay technique.
Carcinoma, Hepatocellular
Selective fast degradation of cytochrome P-450 2E1 in serum-deprived hepatoma cells by a mechanism sensitive to inhibitors of vesicular transport.
Carcinoma, Hepatocellular
Selective induction of the CYP3A family by endosulfan and DNA-adduct formation in different hepatic and hepatoma cells.
Carcinoma, Hepatocellular
Selective suppression of the catalytic activity of cDNA-expressed cytochrome P4502B1 toward polycyclic hydrocarbons in the microsomal membrane: modification of this effect by specific amino acid substitutions.
Carcinoma, Hepatocellular
Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.
Carcinoma, Hepatocellular
Severely Impaired and Dysregulated Cytochrome P450 Expression and Activities in Hepatocellular Carcinoma: Implications for Personalized Treatment in Patients.
Carcinoma, Hepatocellular
Short and long term effects of cytoskeleton-disrupting drugs on cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells: suppression by the microtubule inhibitor nocodazole.
Carcinoma, Hepatocellular
Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells.
Carcinoma, Hepatocellular
Silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic activity: A study in human keratinocytes and human hepatoma cells.
Carcinoma, Hepatocellular
SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor.
Carcinoma, Hepatocellular
Single cell analysis of switch-like induction of CYP1A1 in liver cell lines.
Carcinoma, Hepatocellular
Single-step phototoxic selection procedure for isolating cells that possess aryl hydrocarbon hydroxylase.
Carcinoma, Hepatocellular
Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase.
Carcinoma, Hepatocellular
Sister-chromatid exchange induction by indirect mutagens/carcinogens, aryl hydrocarbon hydroxylase activity and benzo[alpha]pyrene metabolism in cultured human hepatoma cells.
Carcinoma, Hepatocellular
Sorafenib metabolism is significantly altered in the liver tumor tissue of hepatocellular carcinoma patient.
Carcinoma, Hepatocellular
Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity.
Carcinoma, Hepatocellular
Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: A PXR dependent mechanism.
Carcinoma, Hepatocellular
Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s.
Carcinoma, Hepatocellular
Structural and functional characterization of the 5'-flanking region of the rat and human cytochrome P450 2E1 genes: identification of a polymorphic repeat in the human gene.
Carcinoma, Hepatocellular
Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells.
Carcinoma, Hepatocellular
Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450.
Carcinoma, Hepatocellular
Substituted polychlorinated dibenzofuran receptor binding affinities and aryl hydrocarbon hydroxylase induction potencies--a QSAR analysis.
Carcinoma, Hepatocellular
Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells.
Carcinoma, Hepatocellular
Superinduction of Oxidized Tryptophan-Inducible Cytochrome P450 1A1 by Cycloheximide in Hepa lclc7 Cells.
Carcinoma, Hepatocellular
Suppression of aryl hydrocarbon hydroxylase activity in human primary lung carcinoma x mouse hepatoma somatic cell hybrids.
Carcinoma, Hepatocellular
Suppression of CYP1A1 expression by naringenin in murine Hepa-1c1c7 cells.
Carcinoma, Hepatocellular
Suppression of CYP2C9 by MicroRNA hsa-miR-128-3p in Human Liver Cells and Association with Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Suppression of cytochrome P450 (Cyp1a-1) induction in mouse hepatoma Hepa-1C1C7 cells by methoxsalen.
Carcinoma, Hepatocellular
Suppression of Cytochrome P450 1A1 Expression Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mouse Hepatoma Hepa-1c1c7 Cells Treated with Serum of (-)-Epigallocatechin-3-gallate- and Green Tea Extract-Administered Rats.
Carcinoma, Hepatocellular
Suppression of cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells by 12-O-tetradecanoylphorbol-13-acetate and inhibitors of protein kinase C.
Carcinoma, Hepatocellular
Suppression of TCDD-induced cytochrome P450 IA1 activity by staurosporine in mouse primary hepatocyte cultures and hepatoma cells.
Carcinoma, Hepatocellular
Suppressive effects of caraway (Carum carvi) extracts on 2, 3, 7, 8-tetrachloro-dibenzo-p-dioxin-dependent gene expression of cytochrome P450 1A1 in the rat H4IIE cells.
Carcinoma, Hepatocellular
Suspension-mediated induction of Hepa 1c1c7 Cyp1a-1 expression is dependent on the Ah receptor signal transduction pathway.
Carcinoma, Hepatocellular
Sustained induction of cytochrome P4501A1 in human hepatoma cells by co-exposure to benzo[a]pyrene and 7H-dibenzo[c,g]carbazole underlies the synergistic effects on DNA adduct formation.
Carcinoma, Hepatocellular
Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery.
Carcinoma, Hepatocellular
TCDD receptor ligands present in extracts of urban air particulate matter induce aryl hydrocarbon hydroxylase activity and cytochrome P-450c gene expression in rat hepatoma cells.
Carcinoma, Hepatocellular
tert-Butylhydroquinone is a novel aryl hydrocarbon receptor ligand.
Carcinoma, Hepatocellular
The Ah regulatory gene product. Survey of nineteen polycyclic aromatic compounds' and fifteen benzo[a]pyrene metabolites' capacity to bind to the cytosolic receptor.
Carcinoma, Hepatocellular
The Alternaria mycotoxins alternariol and alternariol methyl ether induce cytochrome P450 1A1 and apoptosis in murine hepatoma cells dependent on the aryl hydrocarbon receptor.
Carcinoma, Hepatocellular
The anti-hepatitis B virus therapeutic potential of anthraquinones derived from Aloe vera.
Carcinoma, Hepatocellular
The aromatic hydrocarbon receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin and variable levels of induced aryl hydrocarbon hydroxylase activity in clones of mouse hepatoma cells.
Carcinoma, Hepatocellular
The aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl induces distinct patterns of gene expression between hepatoma and glioma cells: chromatin remodeling as a mechanism for selective effects.
Carcinoma, Hepatocellular
The CYP2B1 proximal promoter contains a functional C/EBP regulatory element.
Carcinoma, Hepatocellular
The cytochrome P450 1A gene (CYP1A) from European flounder (Platichthys flesus), analysis of regulatory regions and development of a dual luciferase reporter gene system.
Carcinoma, Hepatocellular
The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons.
Carcinoma, Hepatocellular
The effect of dimethyl sulfoxide on the function of cytochrome P450 2D6 in HepG2 cells upon the co-expression with NADPH-cytochrome P450 reductase.
Carcinoma, Hepatocellular
The effect of interferon-? on the expression of cytochrome P450 3A4 in human hepatoma cells.
Carcinoma, Hepatocellular
The effect of transcatheter arterial chemoembolization on CYP1A2 activity in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
The effect of transcatheter arterial chemoembolization on phase II drug metabolism enzymes in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
The effects of inducing agents on cytochrome P450 and UDP-glucuronyltransferase activities in human HEPG2 hepatoma cells.
Carcinoma, Hepatocellular
The glycogen synthase kinase inhibitor 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763) is a partial agonist of the aryl hydrocarbon receptor.
Carcinoma, Hepatocellular
The highly bioactive molecule and signal substance 6-formylindolo[3,2-b]carbazole (FICZ) plays bi-functional roles in cell growth and apoptosis in vitro.
Carcinoma, Hepatocellular
The HNF1?-Regulated LncRNA HNF1?-AS1 Is Involved in the Regulation of Cytochrome P450 Expression in Human Liver Tissues and Huh7 Cells.
Carcinoma, Hepatocellular
The human CYP1A2 gene and induction by 3-methylcholanthrene. A region of DNA that supports AH-receptor binding and promoter-specific induction.
Carcinoma, Hepatocellular
The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2.
Carcinoma, Hepatocellular
The induction of the human hepatic CYP2E1 gene by interleukin 4 is transcriptional and regulated by protein kinase C.
Carcinoma, Hepatocellular
The inhibition effect of 2,3,7,8-tetrachlorinated dibenzo-p-dioxin-induced aryl hydrocarbon receptor activation in human hepatoma cells with the treatment of cadmium chloride.
Carcinoma, Hepatocellular
The JAK1/2 Inhibitor Ruxolitinib Reverses Interleukin-6-Mediated Suppression of Drug-Detoxifying Proteins in Cultured Human Hepatocytes.
Carcinoma, Hepatocellular
The mechanism of action of alpha-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.
Carcinoma, Hepatocellular
The murine Cyp1a-1 gene negatively regulates its own transcription and that of other members of the aromatic hydrocarbon-responsive [Ah] gene battery.
Carcinoma, Hepatocellular
The p38 MAPK Inhibitor SB203580 Induces Cytochrome P450 1A1 Gene Expression in Murine and Human Hepatoma Cell Lines through Ligand-Dependent Aryl Hydrocarbon Receptor Activation.
Carcinoma, Hepatocellular
The Synergistic Antitumor Effect of Tanshinone IIA Plus Adriamycin on Human Hepatocellular Carcinoma Xenograft in BALB/C Nude Mice and Their Influences on Cytochrome P450 CYP3A4 In Vivo.
Carcinoma, Hepatocellular
Three new alternative splicing variants of human cytochrome P450 2D6 mRNA in human extratumoral liver tissue.
Carcinoma, Hepatocellular
Time-dependent transcriptional induction of CYP1A1, CYP1A2 and CYP1B1 mRNAs by H+/K+ -ATPase inhibitors and other xenobiotics.
Carcinoma, Hepatocellular
trans-Acting factors, detoxication enzymes and hepatitis B virus replication in a novel set of human hepatoma cell lines.
Carcinoma, Hepatocellular
Transactivation domains facilitate promoter occupancy for the dioxin-inducible CYP1A1 gene in vivo.
Carcinoma, Hepatocellular
Transcription-dependent and transcription-independent nucleosome disruption induced by dioxin.
Carcinoma, Hepatocellular
Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid receptor coactivator 1.
Carcinoma, Hepatocellular
Transcriptional and post-translational regulation of CYP1A1 by primaquine.
Carcinoma, Hepatocellular
Transcriptional and posttranscriptional regulation of CYP1A1 by vanadium in human hepatoma HepG2 cells.
Carcinoma, Hepatocellular
Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol.
Carcinoma, Hepatocellular
Transcriptional and posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by lead in HepG2 cells: a role of heme oxygenase.
Carcinoma, Hepatocellular
Transcriptional regulation of the human CYP1B1 gene. Evidence for involvement of an aryl hydrocarbon receptor response element in constitutive expression.
Carcinoma, Hepatocellular
Transcriptome Analysis of WHV/c-myc Transgenic Mice Implicates Cytochrome P450 Enzyme 17A1 as a Promising Biomarker for Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Trout CYP1A3 Gene: Recognition of Fish DNA Motifs by Mouse Regulatory Proteins.
Carcinoma, Hepatocellular
Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors.
Carcinoma, Hepatocellular
Up-regulation of CYP1A1 by rutaecarpine is dependent on aryl hydrocarbon receptor- and calcium.
Carcinoma, Hepatocellular
Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment.
Carcinoma, Hepatocellular
Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.
Carcinoma, Hepatocellular
Use of bioassays and sediment polycyclic aromatic hydrocarbon concentrations to assess toxicity at coastal sites impacted by Hurricane Katrina.
Carcinoma, Hepatocellular
Use of effect-directed analysis for the identification of organic toxicants in surface flow constructed wetland sediments.
Carcinoma, Hepatocellular
Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines.
Carcinoma, Hepatocellular
Vinclozolin, a widely used fungizide, enhanced BaP-induced micronucleus formation in human derived hepatoma cells by increasing CYP1A1 expression.
Carcinoma, Hepatocellular
Water exposure assessment of aryl hydrocarbon receptor agonists in Three Gorges Reservoir, China using SPMD-based virtual organisms.
Carcinoma, Hepatocellular
Whole-cell biotransformation assay for investigation of the human drug metabolizing enzyme CYP3A7.
Carcinoma, Hepatocellular
[A case-control study on the association of hepatocellular carcinoma with genetic polymorphisms of CYP3A5 in a highly aflatoxin B1 contaminated Guangxi area.]
Carcinoma, Hepatocellular
[Ah receptor-independent inhibition of gap junction intercellular communications in hepatoma cell culture 27 by polycyclic aromatic hydrocarbons]
Carcinoma, Hepatocellular
[Association between aldehyde dehydrogenase-2/cytochrome P450 2E1 genetic polymorphism and habit of alcohol drinking and the susceptibility of hepatocellular carcinoma]
Carcinoma, Hepatocellular
[Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitro].
Carcinoma, Hepatocellular
[Induction of cytochrome P450 2A5 in transplanted mouse hepatoma]
Carcinoma, Hepatocellular
[Mechanism and clinical significance of HBx-mediated inhibition of CYP2E1 expression in the human HepG2 hepatoma cell line].
Carcinoma, Hepatocellular
[New perspectives in the use of human hepatocytes in the preclinical drug development process]
Carcinoma, Hepatocellular
[Study on the relationship between familial clustering of hepatocellular carcinoma and polymorphism of cytochrome P450 2E1 gene in Zhuang population, Guangxi]
Carcinoma, Hepatocellular
[Vitamin D metabolism and signaling in human hepatocellular carcinoma and surrounding non-tumorous liver].
Carcinoma, Intraductal, Noninfiltrating
Utilizing mobile networks for the detection of clinically relevant interactions between chemotherapy regimens and complementary and alternative medicines.
Carcinoma, Large Cell
Identification of a novel co-transcription of P450/1A1 with telomerase in A549.
Carcinoma, Non-Small-Cell Lung
A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population.
Carcinoma, Non-Small-Cell Lung
A regulatory variant in CYP2E1 affects the risk of lung squamous cell carcinoma.
Carcinoma, Non-Small-Cell Lung
Altered regulation of the cytochrome P4501A1 gene: novel inducer-independent gene expression in pulmonary carcinoma cell lines.
Carcinoma, Non-Small-Cell Lung
Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer.
Carcinoma, Non-Small-Cell Lung
Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of non-small cell lung cancer in Andhra Pradesh region of South India.
Carcinoma, Non-Small-Cell Lung
Changes in aromatase (CYP19) gene promoter usage in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Combined effects of serum trace metals and polymorphisms of CYP1A1 or GSTM1 on non-small cell lung cancer: A hospital based case-control study in China.
Carcinoma, Non-Small-Cell Lung
CYP1A1 Ile462Val polymorphism and the risk of non-small cell lung cancer in a Chinese population.
Carcinoma, Non-Small-Cell Lung
CYP2E1 polymorphism, cigarette smoking, p53 expression, and survival in non-small cell lung cancer: a long term follow-up study.
Carcinoma, Non-Small-Cell Lung
CYP4F2 and CYP3A5 gene polymorphisms and lung cancer in Chinese Han population.
Carcinoma, Non-Small-Cell Lung
Cytochrome P450 1B1 (CYP1B1) polymorphisms are associated with clinical outcome of docetaxel in non-small cell lung cancer (NSCLC) patients.
Carcinoma, Non-Small-Cell Lung
Cytochrome P450 2E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation.
Carcinoma, Non-Small-Cell Lung
Cytochrome P450 ?-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Cytochrome P450 expression (CYP) in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Cytochrome P450 in non-small cell lung cancer related to exogenous chemical metabolism.
Carcinoma, Non-Small-Cell Lung
Decreased expression of cytochrome p450 1B1 in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Determinants of Gefitinib toxicity in advanced non-small cell lung cancer (NSCLC): a pharmacogenomic study of metabolic enzymes and transporters.
Carcinoma, Non-Small-Cell Lung
Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Erlotinib treatment induces cytochrome P450 3A activity in non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Expression of aromatase CYP19 and its relationship with parameters in NSCLC.
Carcinoma, Non-Small-Cell Lung
Expression of cytochrome P450 2A13 in human non-small cell lung cancer and its clinical significance.
Carcinoma, Non-Small-Cell Lung
Expression of cytochrome P450 in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms in lung cancer patients from an environmentally polluted region of Poland: correlation with lung DNA adduct levels.
Carcinoma, Non-Small-Cell Lung
Increased cytochrome P450 and aryl hydrocarbon receptor in bronchial epithelium of heavy smokers with non-small cell lung carcinoma carries a poor prognosis.
Carcinoma, Non-Small-Cell Lung
Interaction of the CYP1A1 gene polymorphism and smoking in non-small cell lung cancer susceptibility.
Carcinoma, Non-Small-Cell Lung
Investigating the influence of relevant pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of orally administered docetaxel combined with ritonavir.
Carcinoma, Non-Small-Cell Lung
MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer (NSCLC) through down-regulation of CYP1B1.
Carcinoma, Non-Small-Cell Lung
Overexpression of cytochrome P450 1B1 in advanced non-small cell lung cancer: a potential therapeutic target.
Carcinoma, Non-Small-Cell Lung
p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Carcinoma, Non-Small-Cell Lung
Prognostic significance of germ line polymorphisms of the CYP1A1 and glutathione S-transferase genes in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Reduced CYP2D6 function is associated with gefitinib-induced rash in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Risk of non-small cell lung cancer and the cytochrome P4501A1 Ile462Val polymorphism.
Carcinoma, Non-Small-Cell Lung
The Effect of Rifampin on the Pharmacokinetics and Safety of Lorlatinib: Results of a Phase One, Open-Label, Crossover Study in Healthy Participants.
Carcinoma, Ovarian Epithelial
Association of caffeine intake and CYP1A2 genotype with ovarian cancer.
Carcinoma, Ovarian Epithelial
CYP1B1 enhances the resistance of epithelial ovarian cancer cells to paclitaxel in vivo and in vitro.
Carcinoma, Ovarian Epithelial
CYP1B1 expression in ovarian cancer in the laying hen Gallusdomesticus.
Carcinoma, Ovarian Epithelial
Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression.
Carcinoma, Ovarian Epithelial
Genetic variation of CYP3A5 influences paclitaxel/carboplatin-induced toxicity in Chinese epithelial ovarian cancer patients.
Carcinoma, Ovarian Epithelial
Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk.
Carcinoma, Papillary
Role of the N-acetyltransferase 2 detoxification system in thyroid cancer susceptibility.
Carcinoma, Papillary
Smoking and susceptibility to thyroid cancer: an inverse association with CYP1A1 allelic variants.
Carcinoma, Renal Cell
Association between cytochrome P450 1A1 (CYP1A1) gene polymorphisms and the risk of renal cell carcinoma: a meta-analysis.
Carcinoma, Renal Cell
CYP1A1 activity in renal cell carcinoma and in adjacent normal renal tissue.
Carcinoma, Renal Cell
CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma.
Carcinoma, Renal Cell
CYP3A5 and ABCB1 polymorphisms as predictors for sunitinib outcome in metastatic renal cell carcinoma.
Carcinoma, Renal Cell
Cytochrome P450 1B1 polymorphisms and risk of renal cell carcinoma in men.
Carcinoma, Renal Cell
Effect of the CYP3A5 and ABCB1 genotype on exposure, clinical response and manifestation of toxicities from sunitinib in Asian patients.
Carcinoma, Renal Cell
GSTT1, GSTM1, and CYP1B1 gene polymorphisms and susceptibility to sporadic renal cell cancer.
Carcinoma, Renal Cell
Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b5 Activity.
Carcinoma, Renal Cell
Important role of CYP2J2 in protein kinase inhibitor degradation: a possible role in intratumor drug disposition and resistance.
Carcinoma, Renal Cell
Induction of cytochrome P450 1B1 and catechol estrogen metabolism in ACHN human renal adenocarcinoma cells.
Carcinoma, Renal Cell
Loss of miR-200c up-regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma.
Carcinoma, Renal Cell
Polymorphisms of the CYP1B1 gene as risk factors for human renal cell cancer.
Carcinoma, Renal Cell
Relationship Between CYP1A1 Genetic Polymorphisms and Renal Cancer in China.
Carcinoma, Renal Cell
Relevance of CYP3A5 Expression on the Clinical Outcome of Patients With Renal Cell Carcinoma.
Carcinoma, Renal Cell
Retraction: Polymorphisms of the CYP1B1 Gene as Risk Factors for Human Renal Cell Cancer.
Carcinoma, Renal Cell
Risk of renal cell carcinoma and polymorphism in phase I xenobiotic metabolizing CYP1A1 and CYP2D6 enzymes.
Carcinoma, Renal Cell
Superoxide dismutase and cytochrome P450 isoenzymes might be associated with higher risk of renal cell carcinoma in male patients.
Carcinoma, Renal Cell
Suppression of cytochrome P450 1A1 and 4A1 gene expression in renal carcinomas of TSC2 gene mutant (Eker) rats.
Carcinoma, Renal Cell
Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potential.
Carcinoma, Renal Cell
Vitamin D hydroxylases CYP2R1, CYP27B1 and CYP24A1 in renal cell carcinoma.
Carcinoma, Small Cell
Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens.
Carcinoma, Small Cell
Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population.
Carcinoma, Squamous Cell
A genetic polymorphism in the CYP1B1 gene in patients with squamous cell carcinoma of the esophagus: an Iranian Mashhad cohort study recruited over 10 years.
Carcinoma, Squamous Cell
A regulatory variant in CYP2E1 affects the risk of lung squamous cell carcinoma.
Carcinoma, Squamous Cell
Activation and overexpression of the aryl hydrocarbon receptor contribute to cutaneous squamous cell carcinomas: an immunohistochemical study.
Carcinoma, Squamous Cell
Allelic variations in CYP2D6 gene and susceptibility to cervical cancer.
Carcinoma, Squamous Cell
Altered patterns of cutaneous xenobiotic metabolism in UVB-induced squamous cell carcinoma in SKH-1 hairless mice.
Carcinoma, Squamous Cell
Analysis of the role of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 gene in the risk of squamous cell carcinoma.
Carcinoma, Squamous Cell
Association and treatment response to capecitabine-based chemoradiotherapy with CYP2C9 polymorphism in head and neck cancer.
Carcinoma, Squamous Cell
Association of aryl hydrocarbon receptor and cytochrome P4501B1 expressions in human non-small cell lung cancers.
Carcinoma, Squamous Cell
Association of cigarette smoking and CYP1A1 polymorphisms with adenocarcinoma of the lung by grades of differentiation.
Carcinoma, Squamous Cell
Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma.
Carcinoma, Squamous Cell
Association of cytochrome P450 1B1 haplotypes with head and neck cancer risk.
Carcinoma, Squamous Cell
Association of cytochrome P450 2C9 polymorphism with locally advanced head and neck squamous cell carcinoma and response to concurrent cisplatin-based radical chemoradiation.
Carcinoma, Squamous Cell
Association of cytochrome P450 2E1 genetic polymorphisms with squamous cell carcinoma of the oesophagus.
Carcinoma, Squamous Cell
Association of polymorphism in cytochrome P450 2C9 with susceptibility to head and neck cancer and treatment outcome.
Carcinoma, Squamous Cell
Association of poor metabolizers of cytochrome P450 2C19 with head and neck cancer and poor treatment response.
Carcinoma, Squamous Cell
Association of Smoking and XPG, CYP1A1, OGG1, ERCC5, ERCC1, MMP2, and MMP9 Gene Polymorphisms with the early detection and occurrence of Laryngeal Squamous Carcinoma.
Carcinoma, Squamous Cell
Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line.
Carcinoma, Squamous Cell
Combined CYP1A1/GSTM1 at-risk genotypes are overrepresented in squamous cell lung carcinoma patients but underrepresented in elderly tumor-free subjects.
Carcinoma, Squamous Cell
Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer.
Carcinoma, Squamous Cell
Cyclin D1, glutathione S-transferase, and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: assessment of the importance of individual genes using multivariate analysis.
Carcinoma, Squamous Cell
CYP1A1 and CYP2D6 polymorphism and risk of lung cancer in a North Indian population.
Carcinoma, Squamous Cell
CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro, Brazil.
Carcinoma, Squamous Cell
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung.
Carcinoma, Squamous Cell
CYP1A1 Ile462Val Polymorphism Contributes to Lung Cancer Susceptibility among Lung Squamous Carcinoma and Smokers: A Meta-Analysis.
Carcinoma, Squamous Cell
CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell carcinoma.
Carcinoma, Squamous Cell
CYP1A1, GSTM1 and GSTT1 polymorphisms, tobacco and alcohol status and risk of head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population.
Carcinoma, Squamous Cell
CYP2A6 overexpression in human lung cancers correlates with a high malignant status.
Carcinoma, Squamous Cell
CYP2E1 G1532C, NQO1 Pro187Ser, and CYP1B1 Val432Leu polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck.
Carcinoma, Squamous Cell
Cytochrome P450 1B1 polymorphism drives cancer cell stemness and patient outcome in head-and-neck carcinoma.
Carcinoma, Squamous Cell
Cytochrome P450 2E1 and head and neck cancer: Interaction with genetic and environmental risk factors.
Carcinoma, Squamous Cell
Cytochrome P450 2E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation.
Carcinoma, Squamous Cell
Eldecalcitol (ED-71), an analog of 1?,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas.
Carcinoma, Squamous Cell
Epigenetic and genetic dissections of UV-induced global gene dysregulation in skin cells through multi-omics analyses.
Carcinoma, Squamous Cell
Gene-environment interaction: the role of SULT1A1 and CYP3A5 polymorphisms as risk modifiers for squamous cell carcinoma of the oesophagus.
Carcinoma, Squamous Cell
Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
Carcinoma, Squamous Cell
Genetic polymorphism of xenobiotic metabolising enzymes in Slovenian lung cancer patients.
Carcinoma, Squamous Cell
Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population.
Carcinoma, Squamous Cell
Genetic polymorphisms in Cytochrome P4501B1 and susceptibility to Head and Neck Cancer.
Carcinoma, Squamous Cell
Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males.
Carcinoma, Squamous Cell
Genetic polymorphisms in the Cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx.
Carcinoma, Squamous Cell
Genetic variants in CYP and GST genes, smoking and risk for head and neck cancers: a gene-environment interaction hospital-based case-control study among Canadian Caucasians.
Carcinoma, Squamous Cell
Glutathione S-transferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions.
Carcinoma, Squamous Cell
GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms in lung cancer patients from an environmentally polluted region of Poland: correlation with lung DNA adduct levels.
Carcinoma, Squamous Cell
GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma.
Carcinoma, Squamous Cell
Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.
Carcinoma, Squamous Cell
Immunohistochemical localization of cytochrome P450 2E1 in human pulmonary carcinoma and normal bronchial tissue.
Carcinoma, Squamous Cell
Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China.
Carcinoma, Squamous Cell
Influence of CYP1A1, GSTM1, GSTT1, and NQO1 genotypes and cumulative smoking dose on lung cancer risk in a Swedish population.
Carcinoma, Squamous Cell
Interaction of cytochrome P4501A1 genotypes with other risk factors and susceptibility to lung cancer.
Carcinoma, Squamous Cell
Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response.
Carcinoma, Squamous Cell
Leu432Val Polymorphism of CYP1B1 is Not Associated with Squamous Cell Carcinoma of Esophagus--a Case-Control Study from Kashmir, India.
Carcinoma, Squamous Cell
Meta-analyses of the effect of CYP1A1 and CYP2D6 polymorphisms on the risk of head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
New strategy for the identification of squamous carcinoma antigens that induce therapeutic immune responses in tumor-bearing mice.
Carcinoma, Squamous Cell
p53 gene mutations, and CYP1A1 and GSTM1 genotypes in pulmonary squamous cell carcinomas.
Carcinoma, Squamous Cell
Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.
Carcinoma, Squamous Cell
Polymorphism in cytochrome P450 1A2 and their interaction with risk factors in determining risk of squamous cell lung carcinoma in men.
Carcinoma, Squamous Cell
Polymorphism in cytochrome P450 2A6 and glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome.
Carcinoma, Squamous Cell
Polymorphism in cytochrome P4501A1 is significantly associated with head and neck cancer risk.
Carcinoma, Squamous Cell
Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients.
Carcinoma, Squamous Cell
Polymorphisms and haplotypes of TLR4, TLR9 and CYP1A1 genes possibly interfere with high-risk human papillomavirus infection and cervical cancer susceptibility in Jharkhand, India.
Carcinoma, Squamous Cell
Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe.
Carcinoma, Squamous Cell
Polymorphisms of the CYP1A1 and CYP2E1 genes in head and neck squamous cell carcinoma risk.
Carcinoma, Squamous Cell
Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population.
Carcinoma, Squamous Cell
Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: impact on DNA adduct formation and prevention by polyphenols.
Carcinoma, Squamous Cell
Quantitative assessment of the influence of CYP1B1 polymorphisms and head and neck squamous cell carcinoma risk.
Carcinoma, Squamous Cell
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.
Carcinoma, Squamous Cell
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Carcinoma, Squamous Cell
Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer.
Carcinoma, Squamous Cell
Synergistic association of CYP1A1 polymorphisms with increased susceptibility to squamous cell lung cancer in north Indian smokers.
Carcinoma, Squamous Cell
The frequency of cytochrome P450 2E1 polymorphisms in Black South Africans.
Carcinoma, Squamous Cell
Tobacco carcinogen-metabolizing genes CYP1A1, GSTM1, and GSTT1 polymorphisms and their interaction with tobacco exposure influence the risk of head and neck cancer in Northeast Indian population.
Carcinoma, Squamous Cell
[Applications of aryl hydrocarbon hydroxylase in diagnosis of lung cancer]
Carcinoma, Squamous Cell
[First results on the influence of polymorphisms at glutathione S-transferase, cytochrome P450, and tumor necrosis factor gene loci on the development of multiple head and neck cancer]
Carcinoma, Squamous Cell
[Genetic polymorphism of cytochrome P4501A1 and susceptibility to laryngeal carcinoma]
Carcinoma, Squamous Cell
[Influence of glutathione s-transferase and cytochrome p450 polymorphisms on prognosis of head and neck cancer]
Carcinoma, Squamous Cell
[Studies of the genes related to lung cancer susceptibility in Nanjing Han population, China.]
Carcinoma, Squamous Cell
[Study on the Difference of Gene Expression between Central and Peripheral Lung Squamous Cell Carcinoma Based on TCGA Database].
Carcinoma, Transitional Cell
Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.
Carcinoma, Transitional Cell
Aryl hydrocarbon hydroxylase induction levels in patients with malignant tumors associated with smoking.
Carcinoma, Transitional Cell
Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer.
Carcinoma, Transitional Cell
Cytochrome P450 isoenzyme mRNA expression pattern in human urinary bladder malignancies and normal urothelium.
Cardiomegaly
3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats.
Cardiomegaly
Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart.
Cardiomegaly
Alterations in cytochrome P450-derived arachidonic acid metabolism during pressure overload-induced cardiac hypertrophy.
Cardiomegaly
CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPK?2 and enhancing nuclear translocation of Akt1.
Cardiomegaly
Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line.
Cardiomegaly
Dasatinib induces gene expression of CYP1A1, CYP1B1, and cardiac hypertrophy markers (BNP, ?-MHC) in rat cardiomyocyte H9c2 cells.
Cardiomegaly
Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway.
Cardiomegaly
Early Changes in Cytochrome P450s and Their Associated Arachidonic Acid Metabolites Play a Crucial Role in the Initiation of Cardiac Hypertrophy Induced by Isoproterenol.
Cardiomegaly
Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy.
Cardiomegaly
Fluconazole Represses Cytochrome P450 1B1 and Its Associated Arachidonic Acid Metabolites in the Heart and Protects Against Angiotensin II-Induced Cardiac Hypertrophy.
Cardiomegaly
Identification of 19-(S/R)Hydroxyeicosatetraenoic Acid as the First Endogenous Noncompetitive Inhibitor of Cytochrome P450 1B1 with Enantioselective Activity.
Cardiomegaly
Impact of cigarette smoke exposure on the expression of cardiac hypertrophic genes, cytochrome P450 enzymes, and oxidative stress markers in rats.
Cardiomegaly
In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effects on fetal and adult cardiac gene expression and adult cardiac and renal morphology.
Cardiomegaly
Inhibition of Mid-chain HETEs Protects Against Angiotensin II-induced Cardiac Hypertrophy.
Cardiomegaly
Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats.
Cardiomegaly
Novel Synthetic Analogues of 19(S/R)-Hydroxyeicosatetraenoic Acid Exhibit Noncompetitive Inhibitory Effect on the Activity of Cytochrome P450 1A1 and 1B1.
Cardiomegaly
Resveratrol attenuates angiotensin II-induced cellular hypertrophy through the inhibition of CYP1B1 and the cardiotoxic mid-chain HETE metabolites.
Cardiomegaly
Soluble epoxide hydrolase inhibitor, TUPS, protects against isoprenaline-induced cardiac hypertrophy.
Cardiomegaly
The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats.
Cardiomegaly
The role of cytochrome P450 1B1 and its associated mid-chain hydroxyeicosatetraenoic acid metabolites in the development of cardiac hypertrophy induced by isoproterenol.
Cardiomyopathies
Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice.
Cardiomyopathies
Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity.
Cardiomyopathies
Knockdown of cytochrome P450 2E1 inhibits oxidative stress and apoptosis in the cTnT(R141W) dilated cardiomyopathy transgenic mice.
Cardiomyopathies
Severe acute cardiomyopathy associated with venlafaxine overdose and possible role of CYP2D6 and CYP2C19 polymorphisms.
Cardiomyopathy, Alcoholic
Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy.
Cardiomyopathy, Alcoholic
CYP2J2-derived EETs attenuated ethanol-induced myocardial dysfunction through inducing autophagy and reducing apoptosis.
Cardiomyopathy, Alcoholic
Inhibition of CYP2E1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction and apoptosis.
Cardiomyopathy, Dilated
Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice.
Cardiomyopathy, Dilated
Knockdown of cytochrome P450 2E1 inhibits oxidative stress and apoptosis in the cTnT(R141W) dilated cardiomyopathy transgenic mice.
Cardiomyopathy, Dilated
Metabolism of arachidonic acid by the cytochrome P450 enzyme in patients with chronic Keshan disease and dilated cardiomyopathy.
Cardiomyopathy, Dilated
Molecular chaperone, HSP60, and cytochrome P450 2E1 co-expression in dilated cardiomyopathy.
Cardiotoxicity
Acute arsenic toxicity alters cytochrome P450 and soluble epoxide hydrolase and their associated arachidonic acid metabolism in C57Bl/6 mouse heart.
Cardiotoxicity
Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats.
Cardiotoxicity
Acute Doxorubicin toxicity differentially alters cytochrome p450 expression and arachidonic Acid metabolism in rat kidney and liver.
Cardiotoxicity
Bortezomib: new indication. Second-line treatment of myeloma: limited efficacy, major risks.
Cardiotoxicity
Chronic Doxorubicin Cardiotoxicity Modulates Cardiac Cytochrome P450-Mediated Arachidonic Acid Metabolism in Rats.
Cardiotoxicity
Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore.
Cardiotoxicity
Cyp1 Inhibition Prevents Doxorubicin-Induced Cardiomyopathy in a Zebrafish Heart-Failure Model.
Cardiotoxicity
CYP1A in TCDD toxicity and in physiology-with particular reference to CYP dependent arachidonic acid metabolism and other endogenous substrates.
Cardiotoxicity
CYP1B1 inhibition attenuates doxorubicin-induced cardiotoxicity through a mid-chain HETEs-dependent mechanism.
Cardiotoxicity
CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system.
Cardiotoxicity
Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes.
Cardiotoxicity
Embryonic cardiotoxicity of weak aryl hydrocarbon receptor agonists and CYP1A inhibitor fluoranthene in the Atlantic killifish (Fundulus heteroclitus).
Cardiotoxicity
Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase.
Cardiotoxicity
Liposomal co-delivered oleanolic acid attenuates doxorubicin-induced multi-organ toxicity in hepatocellular carcinoma.
Cardiotoxicity
Major Cardiac-Psychiatric Drug-Drug Interactions: a Systematic Review of the Consistency of Drug Databases.
Cardiotoxicity
Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative.
Cardiotoxicity
Molecular toxicological alterations in the mouse hearts induced by sub-chronic thiazolidinedione drugs administration.
Cardiotoxicity
Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish.
Cardiotoxicity
QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations.
Cardiotoxicity
The metabolism of antihistamines and drug interactions: the role of cytochrome P450 enzymes.
Cardiotoxicity
The role of aryl hydrocarbon receptor signaling pathway in cardiotoxicity of acute lead intoxication in vivo and in vitro rat model.
Cardiotoxicity
The Role of Soluble Epoxide Hydrolase Enzyme on Daunorubicin-Mediated Cardiotoxicity.
Cardiotoxicity
The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish.
Cardiotoxicity
Thymoquinone reduces mitochondrial damage and death of cardiomyocytes induced by clozapine.
Cardiotoxicity
Using Genome-Wide Association Studies to Identify Genes Important in Serious Adverse Drug Reactions.
Cardiotoxicity
Utility of protein structures in overcoming ADMET-related issues of drug-like compounds.
Cardiotoxicity
Zebrafish cardiotoxicity: the effects of CYP1A inhibition and AHR2 knockdown following exposure to weak aryl hydrocarbon receptor agonists.
Cardiotoxicity
[Long QT and torsade de pointes in a patient with acquired human immunodeficiency virus infection in multitherapy with drugs affecting cytochrome P450]
Cardiotoxicity
`Cadmium induced cardiac inflammation in chicken (Gallus gallus) via modulating cytochrome P450 systems and Nrf2 mediated antioxidant defense.
Cardiovascular Diseases
A functional polymorphism in the CYP3A4 gene is associated with increased risk of coronary heart disease in the Chinese Han population.
Cardiovascular Diseases
Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.
Cardiovascular Diseases
Association of CYP1A1 polymorphisms with differential metabolic activation of 17beta-estradiol and estrone.
Cardiovascular Diseases
Association of CYP2C19 variants and epoxyeicosatrienoic acids on patients with microvascular angina.
Cardiovascular Diseases
Association of CYP3A4*1G and CYP3A5*3 With the 1-year Outcome of Acute Ischemic Stroke in the Han Chinese Population.
Cardiovascular Diseases
Biosynthesis of P450 products of arachidonic acid in humans: increased formation in cardiovascular disease.
Cardiovascular Diseases
Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats.
Cardiovascular Diseases
Clinical implications of pharmacogenetics of cytochrome P450 drug metabolizing enzymes.
Cardiovascular Diseases
Constitutive expression and inducibility of CYP1A1 in the H9c2 rat cardiomyoblast cells.
Cardiovascular Diseases
Contribution of CYP24A1 variants in coronary heart disease among the Chinese population.
Cardiovascular Diseases
CYP1B1 genotype and risk of cardiovascular disease, pulmonary disease, and cancer in 50,000 individuals.
Cardiovascular Diseases
CYP2C19 variants and epoxyeicosatrienoic acids in patients with microvascular angina.
Cardiovascular Diseases
CYP2J2 epoxygenase membrane anchor plays an important role in facilitating electron transfer from CPR.
Cardiovascular Diseases
CYP2J2-Derived EETs Attenuated Angiotensin II-Induced Adventitial Remodeling via Reduced Inflammatory Response.
Cardiovascular Diseases
Cytochrome P450 2C19*2 polymorphism in patients with stable coronary heart disease and risk for secondary cardiovascular disease events: results of a long-term follow-up study in routine clinical care.
Cardiovascular Diseases
Cytochrome p450 enzymes in the bioactivation of polyunsaturated Fatty acids and their role in cardiovascular disease.
Cardiovascular Diseases
Cytochrome P450 Pathway Contributes to Methanandamide-induced Vasorelaxation in Rat Aorta.
Cardiovascular Diseases
Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases.
Cardiovascular Diseases
Effects of myricetin, an antioxidant, on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats: possible role of cytochrome P450 3A4, cytochrome P450 2C9 and P-glycoprotein inhibition by myricetin.
Cardiovascular Diseases
Endothelium-specific CYP2J2 overexpression improves cardiac dysfunction by promoting angiogenesis via Jagged1/Notch1 signaling.
Cardiovascular Diseases
Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy.
Cardiovascular Diseases
Gender Differences in the Impact of CYP2C19 Polymorphisms and Low-Grade Inflammation on Coronary Microvascular Disorder.
Cardiovascular Diseases
Genetic and epigenetic polymorphisms of eNOS and CYP2D6 in mainland Chinese Tibetan, Mongolian, Uygur, and Han populations.
Cardiovascular Diseases
Genetic polymorphism of CYP2D6 in patients with cardiovascular disease -- a cohort study.
Cardiovascular Diseases
Genetic variation in the cytochrome P450 epoxygenase pathway and cardiovascular disease risk.
Cardiovascular Diseases
High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population.
Cardiovascular Diseases
Impact of a variable number tandem repeat in the CYP2C9 promoter on warfarin sensitivity and responsiveness in Jordanians with cardiovascular disease.
Cardiovascular Diseases
In men with erectile dysfunction, satisfaction with quality of erections correlates with erection hardness, treatment satisfaction, and emotional well-being.
Cardiovascular Diseases
Influence of CYP4F2, ApoE, and CYP2A6 gene polymorphisms on the variability of Warfarin dosage requirements and susceptibility to cardiovascular disease in Jordan.
Cardiovascular Diseases
Inhibition of Mid-chain HETEs Protects Against Angiotensin II-induced Cardiac Hypertrophy.
Cardiovascular Diseases
Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1.
Cardiovascular Diseases
Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases.
Cardiovascular Diseases
Modulation of cardiac cytochrome P450 in patients with heart failure.
Cardiovascular Diseases
Novel Synthetic Analogues of 19(S/R)-Hydroxyeicosatetraenoic Acid Exhibit Noncompetitive Inhibitory Effect on the Activity of Cytochrome P450 1A1 and 1B1.
Cardiovascular Diseases
PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding.
Cardiovascular Diseases
Pharmacogenetics of Anticoagulation and Clinical Events in Warfarin-Treated Patients: A Register-Based Cohort Study with Biobank Data and National Health Registries in Finland.
Cardiovascular Diseases
Polymorphisms of cytochrome P450 are potential candidates that could potentially help clinicians on the treatment of cardiovascular diseases among Asian populations.
Cardiovascular Diseases
Selective Dual Inhibitors of CYP19 and CYP11B2: Targeting Cardiovascular Diseases Hiding in the Shadow of Breast Cancer.
Cardiovascular Diseases
Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin, Implicated in Human Cardiovascular Diseases, Is Initiated by CYP27A1 via Bile Acid Pathway.
Cardiovascular Diseases
The association of cytochrome P450 1B1 Leu432Val polymorphism with biological markers of health and menopausal symptoms in Slovak midlife women.
Cardiovascular Diseases
The Implication of the Polymorphisms of COX-1, UGT1A6, and CYP2C9 among Cardiovascular Disease (CVD) Patients Treated with Aspirin.
Cardiovascular Diseases
The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease.
Cardiovascular Diseases
The relevance of CYP2D6 genetic polymorphism on chronic metoprolol therapy in cardiovascular patients.
Cardiovascular Diseases
The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins.
Cardiovascular Diseases
Transcriptional Regulation of Drug Metabolizing CYP Enzymes by Proinflammatory Wnt5A Signaling in Human Coronary Artery Endothelial Cells.
Cardiovascular Diseases
[Polymorphisms of genesencoding enzymes of the xenobiotic detoxification system and the risk of infectious endocarditis].
Cardiovascular Diseases
[The most important clinical interactions among medicines used in cardiologic practice]
Cardiovascular Diseases
[The role of genetic polymorphisms of cytochrome P450 in drug metabolism used in the treatment of cardiovascular diseases.]
Catalepsy
Pharmacokinetic factors in sex differences in Delta 9-tetrahydrocannabinol-induced behavioral effects in rats.
Catalepsy
Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: Effects on activity and drug responses.
Cataract
Acetaminophen cytotoxicity in mouse eye: mitochondria in anterior tissues are the primary target.
Cataract
Acetaminophen produces cataract in DBA2 mice by Ah receptor-independent induction of CYP1A2.
Cataract
Cataract formation by a semiquinone metabolite of acetaminophen in mice: possible involvement of Ca(2+)and calpain activation.
Cataract
Cerebrotendinous xanthomatosis (CTX): an association of pulverulent cataracts and pseudo-dominant developmental delay in a family with a splice site mutation in CYP27A1--a case report.
Cataract
Cerebrotendinous xanthomatosis, a metabolic disease with different neurological signs: two case reports.
Cataract
Chinese patient with cerebrotendinous xanthomatosis confirmed by genetic testing: A case report and literature review.
Cataract
Cytotoxic metabolite of acetaminophen, N-acetyl-p-benzoquinone imine, produces cataract in DBA2 mice.
Cataract
In vivo murine studies on the biochemical mechanism of naphthalene cataractogenesis.
Cataract
NGS-Based Diagnosis of Treatable Neurogenetic Disorders in Adults: Opportunities and Challenges.
Cataract
Phenotypes of Recessive Pediatric Cataract in a Cohort of Children with Identified Homozygous Gene Mutations (An American Ophthalmological Society Thesis).
Cataract
Prevention of acetaminophen-induced cataract by a combination of diallyl disulfide and N-acetylcysteine.
Cataract
The inhaled glucocorticoid fluticasone propionate efficiently inactivates cytochrome P450 3A5, a predominant lung P450 enzyme.
Celiac Disease
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Celiac Disease
Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance.
Central Nervous System Diseases
Genetic variants of drug metabolizing enzymes and drug transporter (ABCB1) as possible biomarkers for adverse drug reactions in an HIV/AIDS cohort in Zimbabwe.
Central Nervous System Diseases
Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures.
Central Nervous System Diseases
[Genetic polymorphism and susceptibility to occupational chronic manganism: a case-control study]
Central Serous Chorioretinopathy
Central serous chorioretinopathy induced by drugs metabolized by cytochrome P450 3A4.
Cerebellar Ataxia
Clinical and genetic characteristics of Chinese patients with cerebrotendinous xanthomatosis.
Cerebral Infarction
CYP1A1 and GSTM1/T1 genetic variation in predicting risk for cerebral infarction.
Cerebral Infarction
Interaction between ALOX5AP and CYP3A5 gene variants significantly increases the risk for cerebral infarctions in Chinese.
Cerebral Small Vessel Diseases
Role of soluble epoxide hydrolase in age-related vascular cognitive decline.
Cerebrovascular Disorders
20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease.
Cerebrovascular Disorders
Cytochrome P450 2C19 Polymorphism is Associated with Reduced Clopidogrel Response in Cerebrovascular Disease.
Cerebrovascular Disorders
Cytochrome P450 eicosanoids in cerebrovascular function and disease.
Cerebrovascular Disorders
Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) rs1558139, rs2108622 polymorphisms and susceptibility to several cardiovascular and cerebrovascular diseases.
Cerebrovascular Disorders
Genetic role of CYP4A11 polymorphisms in the risk of developing cardiovascular and cerebrovascular diseases.
Cervical Intraepithelial Neoplasia
Allelic variations in CYP2D6 gene and susceptibility to cervical cancer.
Cervical Intraepithelial Neoplasia
CYP1A1 gene polymorphism as a risk factor for cervical intraepithelial neoplasia and invasive cervical cancer.
Cervical Intraepithelial Neoplasia
Glutathione-S-transferase M1 and T1 and cytochrome P1A1 genetic polymorphisms and susceptibility to cervical intraepithelial neoplasia in Greek women.
Cervical Intraepithelial Neoplasia
Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking.
Cestode Infections
Fine-Scale Analysis of Parasite Resistance Genes in the Red Flour Beetle, Tribolium castaneum.
Chagas Disease
Antitrypanosomal Activity of Sterol 14?-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain.
Chagas Disease
Benznidazole and nifurtimox nitroreductase activity in liver microsomes from male rats preinduced with phenobarbital or 3-methylcholanthrene.
Chagas Disease
Identification of three cytochrome P450 genes in the Chagas' disease vector Triatoma infestans: Expression analysis in deltamethrin susceptible and resistant populations.
Chagas Disease
Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit.
Chemical and Drug Induced Liver Injury
A prospective study of the incidence of drug-induced liver injury by the modern volatile anaesthetics sevoflurane and desflurane.
Chemical and Drug Induced Liver Injury
Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury.
Chemical and Drug Induced Liver Injury
Association of genetic polymorphisms of CYP2E1, NAT2, GST and SLCO1B1 with the risk of anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis.
Chemical and Drug Induced Liver Injury
Bortezomib alleviates drug-induced liver injury by regulating CYP2E1 gene transcription.
Chemical and Drug Induced Liver Injury
Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats.
Chemical and Drug Induced Liver Injury
Characterization of THLE-CYP Cell Lines, Gene Expression Background and Relationship to CYP-enzyme Activity.
Chemical and Drug Induced Liver Injury
Correlation of CpG Island Methylation of the Cytochrome P450 2E1/2D6 Genes with Liver Injury Induced by Anti-Tuberculosis Drugs: A Nested Case-Control Study.
Chemical and Drug Induced Liver Injury
CYP2E1 and miRNA-378a-3p contribute to acetaminophen or tripterygium glycosides induced hepatotoxicity.
Chemical and Drug Induced Liver Injury
CYP2E1 polymorphism, acetylator profiles and drug-induced liver injury incidence of Indonesian tuberculosis patients.
Chemical and Drug Induced Liver Injury
CYP2E1 RsaI/PstI polymorphism and risk of anti-tuberculosis drug-induced liver injury: a meta-analysis.
Chemical and Drug Induced Liver Injury
CYP2E1, GSTM1, and GSTT1 genetic polymorphisms and their associations with susceptibility to antituberculosis drug-induced liver injury in Thai tuberculosis patients.
Chemical and Drug Induced Liver Injury
Cytochrome P450 2E1 Gene Polymorphisms/Haplotypes and Anti-Tuberculosis Drug-Induced Hepatitis in a Chinese Cohort.
Chemical and Drug Induced Liver Injury
Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis.
Chemical and Drug Induced Liver Injury
Cytochromes P450 and UDP-glucuronosyl-transferases as hepatocellular autoantigens.
Chemical and Drug Induced Liver Injury
Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver.
Chemical and Drug Induced Liver Injury
Establishment of a primary human hepatocyte spheroid system for evaluating metabolic toxicity using dacarbazine under conditions of CYP1A2 induction.
Chemical and Drug Induced Liver Injury
Formation of reactive metabolites and management of tyrosine kinase inhibitor-induced hepatotoxicity: a literature review.
Chemical and Drug Induced Liver Injury
Genetic and ethnic risk factors associated with drug hypersensitivity.
Chemical and Drug Induced Liver Injury
Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients.
Chemical and Drug Induced Liver Injury
High daily dose and being a substrate of cytochrome P450 enzymes are two important predictors of drug-induced liver injury.
Chemical and Drug Induced Liver Injury
High-Selectivity Fluorescent Reporter toward Peroxynitrite in a Coexisting Nonalcoholic Fatty Liver and Drug-Induced Liver Diseases Model.
Chemical and Drug Induced Liver Injury
Idiosyncratic Drug Induced Liver Injury, Cytochrome P450, Metabolic Risk Factors and Lipophilicity: Highlights and Controversies.
Chemical and Drug Induced Liver Injury
Initial dosage optimization of tacrolimus in Chinese pediatric patients undergoing kidney transplantation based on population pharmacokinetics and pharmacogenetics.
Chemical and Drug Induced Liver Injury
Involvement of cytochrome P450 1A1 and glutathione S-transferase P1 polymorphisms and promoter hypermethylation in the progression of anti-tuberculosis drug-induced liver injury: a case-control study.
Chemical and Drug Induced Liver Injury
In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries.
Chemical and Drug Induced Liver Injury
Lack of association between genetic polymorphisms of CYP3A4, CYP2C9, CYP2C19 and anti-tuberculosis drug-induced liver injury in community-based Chinese population.
Chemical and Drug Induced Liver Injury
Long-term clinical safety of Clindamycin and Rifampicin combination for the treatment of Hidradenitis suppurativa: a critically appraised topic.
Chemical and Drug Induced Liver Injury
NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis.
Chemical and Drug Induced Liver Injury
Plasma membrane cytochromes P450 as neoantigens and autoimmune targets in drug-induced hepatitis.
Chemical and Drug Induced Liver Injury
Polymorphisms of NAT2, CYP2E1, GST, and HLA related to drug-induced liver injury in indonesian tuberculosis patients.
Chemical and Drug Induced Liver Injury
Prediction of Drug-Induced Liver Injury in HepG2 Cells Cultured with Human Liver Microsomes.
Chemical and Drug Induced Liver Injury
Relationship of anti-tuberculosis drug-induced liver injury and genetic polymorphisms in CYP2E1 and GST.
Chemical and Drug Induced Liver Injury
Role of CYP2E1 immunoglobulin G4 subclass antibodies and complement in pathogenesis of idiosyncratic drug-induced hepatitis.
Chemical and Drug Induced Liver Injury
Role of Inflammatory and Oxidative Stress, Cytochrome P450 2E1, and Bile Acid Disturbance in Rat Liver Injury Induced by Isoniazid and Lipopolysaccharide Cotreatment.
Chemical and Drug Induced Liver Injury
Synonymous mutation rs2515641 affects CYP2E1 mRNA and protein expression and susceptibility to drug-induced liver injury.
Chemical and Drug Induced Liver Injury
The association between cytochrome P450 polymorphisms and anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis.
Chemical and Drug Induced Liver Injury
Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.
Chemical and Drug Induced Liver Injury
[Efficacy and safety of heptral, vitamin B6 and folic acid during toxic hepatitis induced by CCL4]
Chemical and Drug Induced Liver Injury
[Fatal toxic hepatitis in pregnancy. A discussion of the role of methyldopa]
Chemical and Drug Induced Liver Injury
[Pharmacological properties and clinical efficacy of dotinurad (URECE® tablets), a novel hypouricemic agent].
Chemical and Drug Induced Liver Injury
[POLYMORPHISM OF CYP2C9 GENE AND RISK OF HEPATOTOXICITY DEVELOPMENT DURING ANTIRETROVIRAL THERAPY.]
Chikungunya Fever
Molecular cloning and xenobiotic induction of seven novel cytochrome P450 monooxygenases in Aedes albopictus.
Chloracne
Chloracne: a case series on cutaneous expression of CYP1A1 as diagnostic biomarker.
Chloracne
Comparisons of estimated human body burdens of dioxinlike chemicals and TCDD body burdens in experimentally exposed animals.
Chloracne
Expression of AhR, CYP1A1, GSTA1, c-fos and TGF-alpha in skin lesions from dioxin-exposed humans with chloracne.
Chloracne
Therapeutic Agents with AHR Inhibiting and NRF2 Activating Activity for Managing Chloracne.
Cholangiocarcinoma
Association between genetic polymorphisms of CYP1A2, arylamine N-acetyltransferase 1 and 2 and susceptibility to cholangiocarcinoma.
Cholangiocarcinoma
Hepatic cytochrome P450 2A6 and 2E1 status in peri-tumor tissues of patients with Opisthorchis viverrini-associated cholangiocarcinoma.
Cholangiocarcinoma
Inhibitory Activities of Thai Medicinal Plants with Promising Activities Against Malaria and Cholangiocarcinoma on Human Cytochrome P450.
Cholangiocarcinoma
Resveratrol enhances the sensitivity of cholangiocarcinoma to chemotherapeutic agents.
Cholera
Expression of the steroidogenic acute regulatory protein mRNA in adrenal tumors and cultured adrenal cells.
Cholera
Inhibition of basal and stimulated progesterone synthesis by dichlorodiphenyldichloroethylene and methoxychlor in a stable pig granulosa cell line.
Cholera
Regulation of steroidogenesis in jc-410, a stable cell line of porcine granulosa origin.
Cholestasis
Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling.
Cholestasis
Altered Expression of Retinol Metabolism-Related Genes in an ANIT-Induced Cholestasis Rat Model.
Cholestasis
Bile acids produce a generalized reduction of the catalytic activity of cytochromes P450 and other hepatic microsomal enzymes in vitro: relevance to drug metabolism in experimental cholestasis.
Cholestasis
Chenodeoxycholic acid increases the induction of CYP1A1 in HepG2 and H4IIE cells.
Cholestasis
Cholestasis as a dominating symptom of patients with CYP27A1 mutations: An analysis of 17 Chinese infants.
Cholestasis
Cholic Acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice.
Cholestasis
Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis.
Cholestasis
CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid.
Cholestasis
Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease.
Cholestasis
Downregulation of male-specific cytochrome P450s 2C11 and 3A2 in bile duct-ligated male rats: importance to reduced hepatic content of cytochrome P450 in cholestasis.
Cholestasis
Effect of cholestasis produced by bile duct ligation on hepatic heme and hemoprotein metabolism in rats.
Cholestasis
Effects of microplastics (MPs) and tributyltin (TBT) alone and in combination on bile acids and gut microbiota crosstalk in mice.
Cholestasis
Estrogen-Induced Cholestasis Leads to Repressed CYP2D6 Expression in CYP2D6-Humanized Mice.
Cholestasis
Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia.
Cholestasis
Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis.
Cholestasis
Inhibitory effect of short-term bile duct ligation on hepatic cytochrome P450 of bile acid-depleted rats.
Cholestasis
Microsomal and peroxisomal fatty acid oxidation in liver of rats with bile duct ligation and two-thirds hepatectomy.
Cholestasis
No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis.
Cholestasis
Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis.
Cholestasis
Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
Cholestasis
Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis.
Cholestasis
Selective reduction of hepatic cytochrome P450 content in patients with intrahepatic cholestasis. A mechanism for impairment of microsomal drug oxidation.
Cholestasis
Severe Neonatal Cholestasis in Cerebrotendinous Xanthomatosis: Genetics, Immunostaining, Mass Spectrometry.
Cholestasis
The ileum-liver Farnesoid X Receptor signaling axis mediates the compensatory mechanism of 17?-ethynylestradiol-induced cholestasis via increasing hepatic biosynthesis of chenodeoxycholic acids in rats.
Cholestasis
Use of a low-density microarray for studying gene expression patterns induced by hepatotoxicants on primary cultures of rat hepatocytes.
Cholestasis
[Severe protracted cholestasis after general anesthesia in a patient with Alagille syndrome]
Cholestasis, Intrahepatic
Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis.
Cholestasis, Intrahepatic
Selective reduction of hepatic cytochrome P450 content in patients with intrahepatic cholestasis. A mechanism for impairment of microsomal drug oxidation.
Cholestasis, Intrahepatic
The Interaction of PPAR? and CYP7B1 with ER?, ? Impacted the Occurrence and Development of Intrahepatic Cholestasis in Pregnant Rats.
Cholestasis, Intrahepatic
[Association between CYP1A1 gene polymorphism and intrahepatic cholestasis of pregnancy]
Cholestasis, Intrahepatic
[Association of gene polymorphisms of CYP1B1 with intrahepatic cholestasis of pregnancy]
Cholestasis, Intrahepatic
[Interaction among peroxisome proliferators-activated receptor alpha, cytochrome P450 oxysterol 7?-hydroxylase and estrogen receptor and its association with intrahepatic cholestasis in pregnant rats].
Chorea
Methylphenidate-Induced Chorea Due to Possible Cytochrome P450 Metabolism Heterogeneity - A Rare Case.
Chorioamnionitis
The anti-inflammatory role of placental Hofbauer cells is altered in patients with chorioamnionitis: Are CYP2C8 and soluble epoxide hydrolase involved in immunomodulation?
Choriocarcinoma
17alpha-methyl testosterone is a competitive inhibitor of aromatase activity in Jar choriocarcinoma cells and macrophage-like THP-1 cells in culture.
Choriocarcinoma
2-(4'-chlorophenyl)benzothiazole is a potent inducer of cytochrome P450IA1 in a human and a mouse cell line. Anomalous correlation between protein and mRNA induction.
Choriocarcinoma
Characterization of a region upstream of exon I.1 of the human CYP19 (aromatase) gene that mediates regulation by retinoids in human choriocarcinoma cells.
Choriocarcinoma
Estrogen synthetase in choriocarcinoma cell culture. Stimulation by dibutyryl cyclic adenosine monophosphate and theophylline.
Choriocarcinoma
Estrogen synthetase stimulation by dibutyryl cyclic adenosine 3',5'-monophosphate in human choriocarcinoma cell culture: the relative biosynthetic rate of the nicotinamide adenine dinucleotide phosphate (reduced form)-cytochrome c reductase component.
Choriocarcinoma
Estrogen synthetase stimulation by hemin in human choriocarcinoma cell culture.
Choriocarcinoma
Identification and characterization of cis-acting regulatory elements for the expression of the human aromatase cytochrome P-450 gene.
Choriocarcinoma
Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family.
Choriocarcinoma
Macromolecular synthesis is required for stimulation of estrogen synthetase activity by dibutyryl cyclic AMP plus theophylline in choriocarcinoma cell culture.
Choriocarcinoma
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.
Choriocarcinoma
Relationship between aromatase activity and steroid receptor levels in ovarian tumors from postmenopausal women.
Choriocarcinoma
Stimulation of serotonergic 5-HT(2A) receptor signaling increases placental aromatase (CYP19) activity and expression in BeWo and JEG-3 human choriocarcinoma cells.
Choriocarcinoma
Trialkyltin compounds enhance human CG secretion and aromatase activity in human placental choriocarcinoma cells.
Choriocarcinoma
WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells.
Choroidal Neovascularization
Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization.
Choroidal Neovascularization
Cytochrome P450 Oxidase 2C Inhibition Adds to ?-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization.
Choroidal Neovascularization
Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis.
Choroidal Neovascularization
Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD).
Clonorchiasis
Influencing Factors for Cure of Clonorchiasis by Praziquantel Therapy: Infection Burden and CYP3A5 Gene Polymorphism.
Clostridium Infections
Long-term clinical safety of Clindamycin and Rifampicin combination for the treatment of Hidradenitis suppurativa: a critically appraised topic.
Cocarcinogenesis
Molecular non-genetic biomarkers of effect related to methyl thiophanate cocarcinogenesis: organ- and sex-specific cytochrome P450 induction in the rat.
Coinfection
Co-expression of human cytochrome P4501A1 (CYP1A1) variants and human NADPH-cytochrome P450 reductase in the baculovirus/insect cell system.
Coinfection
Coexpression of cytochrome P4502A6 and human NADPH-P450 oxidoreductase in the baculovirus system.
Coinfection
Comparative study of the effects of anti-tuberculosis drugs and antiretroviral drugs on CYP3A4 and P-glycoprotein.
Coinfection
Cytochrome P450 CYP2B6*6 distribution among Congolese individuals with HIV, Tuberculosis and Malaria infection.
Coinfection
Effect of concomitantly administered rifampin on the pharmacokinetics and safety of atazanavir administered twice daily.
Coinfection
Effect of First-Line Antituberculosis Therapy on Nevirapine Pharmacokinetics in Children Younger than Three Years Old.
Coinfection
Establishing Dosing Recommendations for Efavirenz in HIV/TB-Coinfected Children Younger Than 3 Years.
Coinfection
Expression and coupling of human cytochrome P450 2E1 and NADPH-cytochrome P450 oxidoreductase in dual expression and co-infection systems with baculovirus in insect cells.
Coinfection
In vivo phenotyping of cytochrome 450 isoforms involved in the metabolism of anti-HIV and anti-tubercular drugs in human using cocktail approach: An LC-MS/MS analysis.
Coinfection
Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes.
Colitis
Decreased drug penetration in inflamed tissue related to changed mucosal metabolism in experimental colitis.
Colitis
Disturbed bile secretion and cytochrome P450 function during the acute state of experimental colitis in rats.
Colitis
Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis.
Colitis
Effects of dextran sulfate sodium induced experimental colitis on cytochrome P450 activities in rat liver, kidney and intestine.
Colitis
Endotoxin-mediated disturbance of hepatic cytochrome P450 function and development of endotoxin tolerance in the rat model of dextran sulfate sodium-induced experimental colitis.
Colitis
From the Cover: PhIP/DSS-Induced Colon Carcinogenesis in CYP1A-Humanized Mice and the Possible Role of Lgr5+ Stem Cells.
Colitis
Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model.
Colitis
Hepatic early inflammation induces downregulation of hepatic cytochrome P450 expression and metabolic activity in the dextran sulfate sodium-induced murine colitis.
Colitis
Hepatic flavin-containing monooxygenase gene regulation in different mouse inflammation models.
Colitis
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Colitis
Intestinal epithelium-specific knockout of the cytochrome P450 reductase gene exacerbates dextran sulfate sodium-induced colitis.
Colitis
Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis.
Colitis
Review article: the potential mechanisms of action of rifaximin in the management of inflammatory bowel diseases.
Colitis
Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions.
Colitis
TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease.
Colitis, Ulcerative
ATP-binding cassette subfamily B member 1 1236C/T polymorphism significantly affects the therapeutic outcome of tacrolimus in patients with refractory ulcerative colitis.
Colitis, Ulcerative
Changes in the Pharmacokinetics of Phenytoin in Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice.
Colitis, Ulcerative
CYP3A5 genetic polymorphisms affect the pharmacokinetics and short-term remission in patients with ulcerative colitis treated with tacrolimus.
Colitis, Ulcerative
CYP3A5 Genotype as a Potential Pharmacodynamic Biomarker for Tacrolimus Therapy in Ulcerative Colitis in Japanese Patients.
Colitis, Ulcerative
Cytochrome P450 (CYP450,2D6*A), N-Acetyltransferase-2 (NAT2*7, A) and Multidrug Resistance 1 (MDR1 3435 T) Alleles Collectively Increase Risk of Ulcerative Colitis.
Colitis, Ulcerative
Expression of hepatic cytochrome P450 in a mouse model of ulcerative colitis changes with pathological conditions.
Colitis, Ulcerative
Expression of selected cytochrome P450 isoforms and of cooperating enzymes in colorectal tissues in selected pathological conditions.
Colitis, Ulcerative
Individualized treatment based on CYP3A5 single-nucleotide polymorphisms with tacrolimus in ulcerative colitis.
Colitis, Ulcerative
Polymorphism in the Retinoic Acid Metabolizing Enzyme CYP26B1 and the Development of Crohn's Disease.
Colitis, Ulcerative
Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism.
Colitis, Ulcerative
Relationship between CYP2A6 genetic polymorphism, as a marker of nicotine metabolism, and ulcerative colitis.
Colitis, Ulcerative
Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis.
Colitis, Ulcerative
Serum derived from ulcerative colitis mouse changes the metabolism of the fluorescent substrate by P450 depending on the degree of disease progression.
Colitis, Ulcerative
Tacrolimus Dose Optimization Strategy for Refractory Ulcerative Colitis Based on the Cytochrome P450 3A5 Polymorphism Prediction Using Trough Concentration after 24 Hours.
Colitis, Ulcerative
The effect of CYP3A5 genetic polymorphisms on adverse events in patients with ulcerative colitis treated with tacrolimus.
Colitis, Ulcerative
The impact of cytochrome P450 3A genetic polymorphisms on tacrolimus pharmacokinetics in ulcerative colitis patients.
Coloboma
Cyp1b1 Regulates Ocular Fissure Closure Through a Retinoic Acid-Independent Pathway.
Coloboma
Ultra-rare renal diseases diagnosed with whole-exome sequencing: Utility in diagnosis and management.
Colonic Neoplasms
3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease.
Colonic Neoplasms
Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes.
Colonic Neoplasms
Association between CYP24A1 polymorphisms and the risk of colonic polyps and colon cancer in a Chinese population.
Colonic Neoplasms
Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins.
Colonic Neoplasms
Colonic vitamin D metabolism: Implications for the pathogenesis of inflammatory bowel disease and colorectal cancer.
Colonic Neoplasms
CYP24A1 and CYP27B1 Polymorphisms Modulate Vitamin D Metabolism in Colon Cancer Cells.
Colonic Neoplasms
CYP24A1 splice variants-Implications for the antitumorigenic actions of 1,25-(OH)(2)D(3) in colorectal cancer.
Colonic Neoplasms
CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking.
Colonic Neoplasms
Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development.
Colonic Neoplasms
Differentiation-dependent induction of CYP1A1 in cultured rat small intestinal epithelial cells, colonocytes, and human colon carcinoma cells: basement membrane-mediated apoptosis.
Colonic Neoplasms
Duodenal 7-ethoxycoumarin-o-deethylase activity in colon-cancer patients.
Colonic Neoplasms
Effect of butyrate on aromatase cytochrome P450 levels in HT29, DLD-1 and LoVo colon cancer cells.
Colonic Neoplasms
Effect of chronic dietary ethanol consumption on colonic cancer in rats induced by 1,1-dimethylhydrazine.
Colonic Neoplasms
Effect of cytochrome P450 inducers on expression of oncogenes and a tumor suppressor gene in human colon cancer cells.
Colonic Neoplasms
Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells.
Colonic Neoplasms
Effects of diet and ethanol on the expression and localization of cytochromes P450 2E1 and P450 2C7 in the colon of male rats.
Colonic Neoplasms
Effects of indole-3-carbinol and phenethyl isothiocyanate on colon carcinogenesis induced by azoxymethane in rats.
Colonic Neoplasms
Epigenetic regulation of the 1,25-dihydroxyvitamin D(3) 24-hydroxylase (CYP24A1) in colon cancer cells.
Colonic Neoplasms
Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur.
Colonic Neoplasms
Expression Patterns of Xenobiotic-Metabolizing Enzymes in Tumor and Adjacent Normal Mucosa Tissues among Patients with Colorectal Cancer: The ColoCare Study.
Colonic Neoplasms
Fractionation of polyphenol-enriched apple juice extracts to identify constituents with cancer chemopreventive potential.
Colonic Neoplasms
Fucoxanthin Attenuates Rifampin-Induced Cytochrome P450 3A4 (CYP3A4) and Multiple Drug Resistance 1 (MDR1) Gene Expression Through Pregnane X Receptor (PXR)-Mediated Pathways in Human Hepatoma HepG2 and Colon Adenocarcinoma LS174T Cells.
Colonic Neoplasms
Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population.
Colonic Neoplasms
Genetic polymorphisms in the cytochrome P450 1A1, glutathione S-transferase M1 and T1, and susceptibility to colon cancer.
Colonic Neoplasms
Genetic Predictors of Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer.
Colonic Neoplasms
Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: Colon cancer family registry.
Colonic Neoplasms
Genistein affects expression of cytochrome P450 (CYP450) genes in hepatocellular carcinoma (HEPG2/C3A) cell line.
Colonic Neoplasms
Hydroxylated Chalcones as Aryl Hydrocarbon Receptor Agonists: Structure-Activity Effects.
Colonic Neoplasms
Identification and clinical validation of metastasis-associated biomarkers based on large-scale samples in colon-adenocarcinoma.
Colonic Neoplasms
Induction of colon adenocarcinomas in CD rats and lung adenomas in ICR mice by 6-nitrochrysene: comparison of carcinogenicity and aryl hydrocarbon hydroxylase induction in the target organs of each species.
Colonic Neoplasms
Innovational combination of hetero-bifunctional N-PEG quinoline scaffolds derivatives with improved anticancer activity against breast and colon cancer cell lines and P-glycoprotein, cytochrome p450 enzyme activity prediction.
Colonic Neoplasms
Intestinal bacterium-derived cyp27a1 prevents colon cancer cell apoptosis.
Colonic Neoplasms
Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure-Activity Relationships.
Colonic Neoplasms
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
Colonic Neoplasms
Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4.
Colonic Neoplasms
Molecular cloning of the guinea pig CYP1A2 gene 5'-flanking region: identification of functional aromatic hydrocarbon response element and characterization of CYP1A2 expression in GPC16 cells.
Colonic Neoplasms
Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells.
Colonic Neoplasms
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Colonic Neoplasms
Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24.
Colonic Neoplasms
Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers.
Colonic Neoplasms
Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavones.
Colonic Neoplasms
Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis.
Colonic Neoplasms
Ten polymorphisms of estrogen-metabolizing genes and a family history of colon cancer--an association study of multiple gene-gene interactions.
Colonic Neoplasms
The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol.
Colonic Neoplasms
Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.
Colonic Neoplasms
[Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitro].
Colonic Neoplasms
[Genetic polymorphism in cytochrome P450 2E1, salted food and colorectal cancer susceptibility: a case-control study]
Colonic Neoplasms
[Genetic polymorphisms in xenobiotic metabolizing enzymes as a determinant of susceptibility to environmental mutagens and carcinogens in humans]
Colorectal Neoplasms
5-Fluorouracil prodrug: role of anabolic and catabolic pathway modulation in therapy of colorectal cancer.
Colorectal Neoplasms
A candidate intronic CYP24A1 gene variant affects the risk of colorectal cancer.
Colorectal Neoplasms
A case-control study of CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in colorectal cancer.
Colorectal Neoplasms
A novel circular RNA hsa_circ_0060927 may serve as a potential diagnostic biomarker for human colorectal cancer.
Colorectal Neoplasms
A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population.
Colorectal Neoplasms
A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.
Colorectal Neoplasms
A Phase II study of clinical outcomes of 3-week cycles of irinotecan and S-1 in patients with previously untreated metastatic colorectal cancer: influence of the UGT1A1 and CYP2A6 polymorphisms on clinical activity.
Colorectal Neoplasms
A prospective study of cytochrome P450 1A1 polymorphisms and colorectal cancer risk in men.
Colorectal Neoplasms
A randomized clinical trial of the effects of supplemental calcium and vitamin D3 on markers of their metabolism in normal mucosa of colorectal adenoma patients.
Colorectal Neoplasms
Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8.
Colorectal Neoplasms
Analysis of the Functional Polymorphism in the Cytochrome P450 CYP2C8 Gene rs11572080 with Regard to Colorectal Cancer Risk.
Colorectal Neoplasms
Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk.
Colorectal Neoplasms
Association between allelic polymorphisms of metabolizing enzymes (CYP 1A1, CYP 1A2, CYP 2E1, mEH) and occurrence of colorectal cancer in Hungary.
Colorectal Neoplasms
Association between CYP1A1 2454A > G polymorphism and colorectal cancer risk: A meta-analysis.
Colorectal Neoplasms
Association between CYP1A1 polymorphism and colorectal cancer risk: a meta-analysis.
Colorectal Neoplasms
Association between CYP1A2 and CYP1B1 polymorphisms and colorectal cancer risk: a meta-analysis.
Colorectal Neoplasms
Association between cytochrome P450 2C9 gene polymorphisms and colorectal cancer susceptibility: evidence from 16 case-control studies.
Colorectal Neoplasms
Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of colorectal cancer: A hospital-based case-control study in Japan.
Colorectal Neoplasms
Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population.
Colorectal Neoplasms
Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan.
Colorectal Neoplasms
Association of CYP1A1, CYP1A2, GSTM1 and NAT2 Gene Polymorphisms with Colorectal Cancer and Smoking.
Colorectal Neoplasms
Association of CYP24A1 gene polymorphism with colorectal cancer in the Jiamusi population.
Colorectal Neoplasms
Association of CYP2C9 genotypes leading to high enzyme activity and colorectal cancer risk.
Colorectal Neoplasms
Association of GSTM1, GSTT1, GSTP1 and CYP2E1 Single Nucleotide Polymorphisms with Colorectal Cancer in Iran.
Colorectal Neoplasms
Associations between CYP1A1 rs1048943 A > G and rs4646903 T > C genetic variations and colorectal cancer risk: Proof from 26 case-control studies.
Colorectal Neoplasms
Associations of CYP2E1 rs2031920 and rs3813867 polymorphisms with colorectal cancer risk: a systemic review and meta-analysis.
Colorectal Neoplasms
Bi-functional induction of the quinone reductase and cytochrome P450 1A1 by youngiasides via Nrf2-ARE and AhR-XRE pathways.
Colorectal Neoplasms
Case-only study of interactions between metabolic enzymes and smoking in colorectal cancer.
Colorectal Neoplasms
Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.
Colorectal Neoplasms
Coexistence of copy number increases of ZNF217 and CYP24A1 in colorectal cancers in a Chinese population.
Colorectal Neoplasms
Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-Results from the EPIC cohort study.
Colorectal Neoplasms
Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of Scotland.
Colorectal Neoplasms
Colorectal cancer risk in relation to genetic polymorphism of cytochrome P450 1A1, 2E1, and glutathione-S-transferase M1 enzymes.
Colorectal Neoplasms
Colorectal cancer specific cytochrome P450 2W1 (CYP2W1): intracellular localization, glycosylation, and catalytic activity.
Colorectal Neoplasms
Combinations of cytochrome P450 gene polymorphisms enhancing the risk for sporadic colorectal cancer related to red meat consumption.
Colorectal Neoplasms
Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk.
Colorectal Neoplasms
CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients.
Colorectal Neoplasms
CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: A meta-analysis.
Colorectal Neoplasms
CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenoma.
Colorectal Neoplasms
CYP1B1 Asn453Ser polymorphism and colorectal cancer risk: a meta-analysis.
Colorectal Neoplasms
CYP1B1 Leu432Val polymorphism and colorectal cancer risk among Caucasians: a meta-analysis.
Colorectal Neoplasms
CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers.
Colorectal Neoplasms
CYP24A1 and CYP27B1 Polymorphisms Modulate Vitamin D Metabolism in Colon Cancer Cells.
Colorectal Neoplasms
CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells.
Colorectal Neoplasms
CYP24A1 Inhibition Facilitates the Antiproliferative Effect of 1,25(OH)2D3 Through Downregulation of the WNT/?-Catenin Pathway and Methylation-Mediated Regulation of CYP24A1 in Colorectal Cancer Cells.
Colorectal Neoplasms
CYP24A1 is a potential biomarker for the progression and prognosis of human colorectal cancer.
Colorectal Neoplasms
CYP24A1 splice variants-Implications for the antitumorigenic actions of 1,25-(OH)(2)D(3) in colorectal cancer.
Colorectal Neoplasms
CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk.
Colorectal Neoplasms
CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk.
Colorectal Neoplasms
CYP2D6 metabolism and patient outcome in the Austrian Breast and Colorectal Cancer Study Group trial (ABCSG) 8.
Colorectal Neoplasms
CYP2E1 polymorphisms and colorectal cancer risk: a HuGE systematic review and meta-analysis.
Colorectal Neoplasms
CYP2E1 PstI/RsaI polymorphism and colorectal cancer risk: a meta-analysis.
Colorectal Neoplasms
CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking.
Colorectal Neoplasms
CYP2E1 RsaI and 96-bp insertion genetic polymorphisms associated with risk for colorectal cancer.
Colorectal Neoplasms
CYP2E1 T7632A and 9-bp insertion polymorphisms and colorectal cancer risk: a meta-analysis based on 4,592 cases and 5,918 controls.
Colorectal Neoplasms
CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648) sensitivity in breast and colorectal cancer cells.
Colorectal Neoplasms
Cytochrome P450 1A1, 2E1 and GSTM1 gene polymorphisms and susceptibility to colorectal cancer in the Saudi population.
Colorectal Neoplasms
Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development.
Colorectal Neoplasms
Cytochrome P450 content in primary tumors and liver metastases of patients with metastatic colorectal cancer.
Colorectal Neoplasms
Cytochrome P450 monooxygenase/soluble epoxide hydrolase-mediated eicosanoid pathway in colorectal cancer and obesity-associated colorectal cancer.
Colorectal Neoplasms
Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
Colorectal Neoplasms
Design, Synthesis, and Biological Evaluation of Cytochrome P450 1B1 Targeted Molecular Imaging Probes for Colorectal Tumor Detection.
Colorectal Neoplasms
Detection of cytochrome P450 1B1 Bfr I polymorphism: genotype distribution in healthy German individuals and in patients with colorectal carcinoma.
Colorectal Neoplasms
Dietary Flavonoids, CYP1A1 Genetic Variants, and the Risk of Colorectal Cancer in a Korean population.
Colorectal Neoplasms
Dysregulation of vitamin D synthesis pathway genes in colorectal cancer: A case-control study.
Colorectal Neoplasms
Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans.
Colorectal Neoplasms
Effects of polymorphic cytochrome P450 2A6 genotypes on chemoprevention against colorectal tumors in single Japanese cohort using daily low-dose aspirin: insights into future personalized treatments.
Colorectal Neoplasms
Epigenetic regulation of the 1,25-dihydroxyvitamin D(3) 24-hydroxylase (CYP24A1) in colon cancer cells.
Colorectal Neoplasms
Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study.
Colorectal Neoplasms
Evaluation of Lynch syndrome modifier genes in 748 MMR mutation carriers.
Colorectal Neoplasms
Exploratory Genome-Wide Interaction Analysis of Nonsteroidal Anti-inflammatory Drugs and Predicted Gene Expression on Colorectal Cancer Risk.
Colorectal Neoplasms
Expression of CYP1B1 and B7-H3 significantly correlates with poor prognosis in colorectal cancer patients.
Colorectal Neoplasms
Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy.
Colorectal Neoplasms
Expression Patterns of Xenobiotic-Metabolizing Enzymes in Tumor and Adjacent Normal Mucosa Tissues among Patients with Colorectal Cancer: The ColoCare Study.
Colorectal Neoplasms
Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling.
Colorectal Neoplasms
Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines.
Colorectal Neoplasms
Genetic polymorphism in cytochrome P450 7A1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study.
Colorectal Neoplasms
Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer.
Colorectal Neoplasms
Genetic polymorphism of xenobiotic metabolising enzymes, diet and cancer susceptibility.
Colorectal Neoplasms
Genetic polymorphisms in cytochrome P450 and clinical outcomes of FOLFIRI chemotherapy in patients with metastatic colorectal cancer.
Colorectal Neoplasms
Genetic polymorphisms of CYP2E1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study.
Colorectal Neoplasms
Genetic polymorphisms of vitamin D metabolism genes and serum level of vitamin D in colorectal cancer.
Colorectal Neoplasms
Genetic polymorphisms of vitamin D receptor (VDR), CYP27B1 and CYP24A1 genes and the risk of colorectal cancer.
Colorectal Neoplasms
Genetic Predictors of Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer.
Colorectal Neoplasms
Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients.
Colorectal Neoplasms
Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome.
Colorectal Neoplasms
Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: Colon cancer family registry.
Colorectal Neoplasms
Genetic Variations in the Xenobiotic-Metabolizing Enzymes CYP1A1, CYP1A2, CYP2C9, CYP2C19 and Susceptibility to Colorectal Cancer Among Turkish People.
Colorectal Neoplasms
Genotyping of CYP3A5 polymorphisms among Bulgarian patients with sporadic colorectal cancer and controls.
Colorectal Neoplasms
Heterocyclic amine intake, smoking, cytochrome P450 1A2 and N-acetylation phenotypes, and risk of colorectal adenoma in a multiethnic population.
Colorectal Neoplasms
Impact of CYP24A1 overexpression on growth of colorectal tumour xenografts in mice fed with vitamin D and soy.
Colorectal Neoplasms
Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer.
Colorectal Neoplasms
Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans.
Colorectal Neoplasms
Inhibitory Effect of 5-Fluorouracil on Cytochrome P450 2C9 Activity in Cancer Patients.
Colorectal Neoplasms
Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention.
Colorectal Neoplasms
Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3.
Colorectal Neoplasms
Keratinocyte Growth Factor Regulation of Aryl Hydrocarbon Receptor Activation in Colorectal Cancer Cells.
Colorectal Neoplasms
Meta-analysis of association studies of CYP1A1 genetic polymorphisms with digestive tract cancer susceptibility in Chinese.
Colorectal Neoplasms
Meta-analysis of cytochrome P-450 2C9 polymorphism and colorectal cancer risk.
Colorectal Neoplasms
miR-30a promoter variation contributes to the increased risk of colorectal cancer in an Iranian population.
Colorectal Neoplasms
No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARdelta and PPARgamma act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma.
Colorectal Neoplasms
No modification of the beneficial effect of NSAIDs on colorectal cancer by CYP2C9 genotype.
Colorectal Neoplasms
Novel long noncoding RNAs upregulation may have synergistic effects on the CYP24A1 and PFDN4 biomarker role in human colorectal cancer.
Colorectal Neoplasms
Novel markers of susceptibility to carcinogens in diet: associations with colorectal cancer.
Colorectal Neoplasms
Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Colorectal Neoplasms
Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.
Colorectal Neoplasms
Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk.
Colorectal Neoplasms
Polymorphisms of cytochrome P450 1A2 and N-acetyltransferase genes, meat consumption, and risk of colorectal cancer.
Colorectal Neoplasms
Potential of Teucrium chamaedrys L. to modulate apoptosis and biotransformation in colorectal carcinoma cells.
Colorectal Neoplasms
PPAR? plays an important role in the migration activity, and the expression of CYP2S1 and CYP1B1 in chrysin-treated HCT116 cells.
Colorectal Neoplasms
Prediction of Early Recurrence After Curative Resection of Colorectal Liver Metastasis and Subsequent S-1 Chemotherapy.
Colorectal Neoplasms
Quantitative assessment of the effect of cytochrome P450 2C9 gene polymorphism and colorectal cancer.
Colorectal Neoplasms
Quantitative Assessment of the Influence of Cytochrome P450 1A2 Gene Polymorphism and Colorectal Cancer Risk.
Colorectal Neoplasms
Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps.
Colorectal Neoplasms
Red meat intake, CYP2E1 and PPAR? polymorphisms, and colorectal cancer risk.
Colorectal Neoplasms
Red meat intake, CYP2E1 genetic polymorphisms, and colorectal cancer risk.
Colorectal Neoplasms
Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.
Colorectal Neoplasms
Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in colorectal cancer.
Colorectal Neoplasms
Relationship between metabolic enzyme polymorphism and colorectal cancer.
Colorectal Neoplasms
Relative Expression of Vitamin D Hydroxylases, CYP27B1 and CYP24A1, and of Cyclooxygenase-2 and Heterogeneity of Human Colorectal Cancer in Relation to Age, Gender, Tumor Location, and Malignancy: Results from Factor and Cluster Analysis.
Colorectal Neoplasms
Role of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population.
Colorectal Neoplasms
Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer.
Colorectal Neoplasms
The association of CYP2C9 gene polymorphisms with colorectal carcinoma in Han Chinese.
Colorectal Neoplasms
The CYP1A1 genotype may alter the association of meat consumption patterns and preparation with the risk of colorectal cancer in men and women.
Colorectal Neoplasms
The expression of CYP2W1 in colorectal primary tumors, corresponding lymph node metastases and liver metastases.
Colorectal Neoplasms
The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis.
Colorectal Neoplasms
Toxicological aspects of flavonoid interaction with biomacromolecules.
Colorectal Neoplasms
Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer.
Colorectal Neoplasms
Using a combination of cytochrome P450 1B1 and beta-catenin for early diagnosis and prevention of colorectal cancer.
Colorectal Neoplasms
Variant alleles of the CYP1B1 gene are associated with colorectal cancer susceptibility.
Colorectal Neoplasms
[Association between genetic polymorphisms of metabolic enzymes and susceptibility of colorectal cancer]
Colorectal Neoplasms
[Genetic polymorphism in cytochrome P450 2E1, salted food and colorectal cancer susceptibility: a case-control study]
Colorectal Neoplasms
[Validation of genetic polymorphisms associated to the toxicity of chemotherapy in colorectal cancer patients].
Colorectal Neoplasms, Hereditary Nonpolyposis
Evaluation of Lynch syndrome modifier genes in 748 MMR mutation carriers.
Colorectal Neoplasms, Hereditary Nonpolyposis
Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome.
Colorectal Neoplasms, Hereditary Nonpolyposis
Polymorphisms of xenobiotic-metabolizing genes and colorectal cancer risk in patients with lynch syndrome: A retrospective cohort study in Taiwan.
Coma
Dosing Recommendations for Quetiapine When Coadministered With HIV Protease Inhibitors.
Coma
Factors Predisposing to Coma and Delirium: Fentanyl and Midazolam Exposure; CYP3A5, ABCB1, and ABCG2 Genetic Polymorphisms; and Inflammatory Factors*.
Communicable Diseases
African variation at Cytochrome P450 genes: Evolutionary aspects and the implications for the treatment of infectious diseases.
Communicable Diseases
HepaRG cells as human-relevant in vitro model to study the effects of inflammatory stimuli on cytochrome P450 isoenzymes.
Communicable Diseases
Mechanism of hepatic cytochrome P450 modulation during Listeria monocytogenes infection in mice.
Communicable Diseases
Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.
Communicable Diseases
Modulatory effect of hyperthermia on hepatic microsomal cytochrome P450 in mice.
Communicable Diseases
Regulation of drug metabolism and disposition during inflammation and infection.
Communicable Diseases
Whole Exome Sequencing Among 26 Patients With Indeterminate Acute Liver Failure: A Pilot Study.
Confusion
CYP2D6 genotype predicts tamoxifen discontinuation and drug response: a secondary analysis of the KARISMA trial.
Confusion
Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver.
Confusion
Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group.
Congenital Abnormalities
AHR-related activities in a creosote-adapted population of adult atlantic killifish, Fundulus heteroclitus, two decades post-EPA superfund status at the Atlantic Wood Site, Portsmouth, VA USA.
Congenital Abnormalities
AHR2 morpholino knockdown reduces the toxicity of total particulate matter to zebrafish embryos.
Congenital Abnormalities
AHR2-Mediated Transcriptomic Responses Underlying the Synergistic Cardiac Developmental Toxicity of PAHs.
Congenital Abnormalities
Application of molecular endpoints in early life stage salmonid environmental biomonitoring.
Congenital Abnormalities
Characterization of the recalcitrant CYP1 phenotype found in Atlantic killifish (Fundulus heteroclitus) inhabiting a Superfund site on the Elizabeth River, VA.
Congenital Abnormalities
CYP1B1 knockdown does not alter synergistic developmental toxicity of polycyclic aromatic hydrocarbons in zebrafish (Danio rerio).
Congenital Abnormalities
Developmental and latent effects of diluted bitumen exposure on early life stages of sockeye salmon (Oncorhynchus nerka).
Congenital Abnormalities
DNA damage and health effects in juvenile haddock (Melanogrammus aeglefinus) exposed to PAHs associated with oil-polluted sediment or produced water.
Congenital Abnormalities
Effects of the polycyclic aromatic hydrocarbon heterocycles, carbazole and dibenzothiophene, on in vivo and in vitro CYP1A activity and polycyclic aromatic hydrocarbon-derived embryonic deformities.
Congenital Abnormalities
Environmental concentrations of benz[a]anthracene induce developmental defects and DNA damage and impair photomotor response in Japanese medaka larvae.
Congenital Abnormalities
Evaluation of environmental impact on natural populations of the Mediterranean killifish Aphanius fasciatus by quantitative RNA biomarkers.
Congenital Abnormalities
For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential.
Congenital Abnormalities
Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction.
Congenital Abnormalities
Is oxidative stress the mechanism of blue sac disease in retene-exposed trout larvae?
Congenital Abnormalities
Persistent effects on adult swim performance and energetics in zebrafish developmentally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Congenital Abnormalities
Phenotypic anchoring of gene expression after developmental exposure to aryl hydrocarbon receptor ligands in zebrafish.
Congenital Abnormalities
Polluted-site killifish (Fundulus heteroclitus) embryos are resistant to organic pollutant-mediated induction of CYP1A activity, reactive oxygen species, and heart deformities.
Congenital Abnormalities
Relationship between low midazolam metabolism by cytochrome P450 3A in mice and the high incidence of birth defects.
Congenital Abnormalities
Resistance to polycyclic aromatic hydrocarbon toxicity and associated bioenergetic consequences in a population of Fundulus heteroclitus.
Congenital Abnormalities
Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus.
Congenital Abnormalities
Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish.
Congenital Abnormalities
Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors.
Congenital Abnormalities
Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in developing red seabream (Pagrus major) embryo: an association of morphological deformities with AHR1, AHR2 and CYP1A expressions.
Congenital Abnormalities
Zebrafish cardiotoxicity: the effects of CYP1A inhibition and AHR2 knockdown following exposure to weak aryl hydrocarbon receptor agonists.
Congenital Microtia
Identification of a novel CYP26A1 mutation in a Chinese family with congenital microtia.
Conjunctivitis, Allergic
Ritonavir and Topical Ocular Corticosteroid Induced Cushing's Syndrome in an Adolescent with HIV-1 Infection.
Connective Tissue Diseases
Effect of CYP3A5 and ABCB1 polymorphisms on the interaction between tacrolimus and itraconazole in patients with connective tissue disease.
Connective Tissue Diseases
Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases.
Corneal Diseases
Genetics of Congenital Corneal Opacification-Impact on Diagnosis and Treatment.
Corneal Neovascularization
Inhibition of VEGF expression and corneal neovascularization by siRNA targeting cytochrome P450 4B1.
Corneal Opacity
CYP1B1-Related Anterior Segment Developmental Anomalies Novel Mutations for Infantile Glaucoma and Von Hippel's Ulcer Revisited.
Corneal Ulcer
CYP1B1 Cytopathy: Uncommon Phenotype of a Homozygous CYP1B1 Deletion as Internal Corneal Ulcer of Von Hippel.
Coronary Artery Disease
?2A-Adrenergic Receptor Polymorphism Potentiates Platelet Reactivity in Patients With Stable Coronary Artery Disease Carrying the Cytochrome P450 2C19*2 Genetic Variant.
Coronary Artery Disease
Are the T/C polymorphism of the CYP17 gene and the tetranucleotide repeat (TTTA) polymorphism of the CYP19 gene genetic markers for premature coronary artery disease in Caucasians?
Coronary Artery Disease
Association between cytochrome P450 2C19 polymorphism and clinical outcomes in Chinese patients with coronary artery disease.
Coronary Artery Disease
Association of CYP2C19, CYP3A5 and GPIIb/IIIa gene polymorphisms with Aspirin and Clopidogrel Resistance in a cohort of Indian patients with Coronary Artery Disease.
Coronary Artery Disease
Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease.
Coronary Artery Disease
Caffeine intake reduces incident atrial fibrillation at a population level.
Coronary Artery Disease
CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation.
Coronary Artery Disease
CYP2D6 (C2850T, G1846A, C100T) polymorphisms, haplotypes and MDR analysis in predicting coronary artery disease risk in north-west Indian population: A case-control study.
Coronary Artery Disease
Cytochrome P450 2C19 Polymorphism in Iranian Patients with Coronary Artery Disease.
Coronary Artery Disease
Cytochrome P450 2C19 polymorphism is associated with poor clinical outcomes in coronary artery disease patients treated with clopidogrel.
Coronary Artery Disease
Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease.
Coronary Artery Disease
Cytochrome P450 genes in coronary artery diseases: Codon usage analysis reveals genomic GC adaptation.
Coronary Artery Disease
Cytochrome P450-derived eicosanoids and vascular dysfunction in coronary artery disease patients.
Coronary Artery Disease
Cytochrome P450-derived epoxyeicosatrienoic acids and coronary artery disease in humans: a targeted metabolomics study.
Coronary Artery Disease
Diplotypes of CYP2C9 gene is associated with coronary artery disease in the Xinjiang Han population for women in China.
Coronary Artery Disease
Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes.
Coronary Artery Disease
Effects of cytochrome P450 2C19 and paraoxonase 1 polymorphisms on antiplatelet response to clopidogrel therapy in patients with coronary artery disease.
Coronary Artery Disease
Erratum to: The association between CYP1A1 genetic polymorphisms and coronary artery disease in the Uygur and Han of China.
Coronary Artery Disease
Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease.
Coronary Artery Disease
Gender-Specific Effect of CYP2C8*3 on the Risk of Essential Hypertension in Bulgarian Patients.
Coronary Artery Disease
Gene-gene interaction between PPARG and CYP1A1 gene on coronary artery disease in the Chinese Han Population.
Coronary Artery Disease
Genetic polymorphisms of the CYP1A1, GSTM1, and GSTT1 enzymes and their influence on cardiovascular risk and lipid profile in people who live near a natural gas plant.
Coronary Artery Disease
GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and susceptibility to smoking-related coronary artery disease: a case-only study.
Coronary Artery Disease
Impact of CYP2C8 and 2C9 polymorphisms on coronary artery disease and myocardial infarction in the LURIC cohort.
Coronary Artery Disease
Impact of CYP3A5 polymorphism on platelet reactivity at percutaneous coronary intervention and after 9 months of aspirin and clopidogrel therapy in Japanese patients with coronary artery disease.
Coronary Artery Disease
Impact of Genetic Variations of the CYP1A1, GSTT1, and GSTM1 Genes on the Risk of Coronary Artery Disease.
Coronary Artery Disease
Impact of interaction between CYP1A1 genetic polymorphisms and smoking on coronary artery disease in the Han of China.
Coronary Artery Disease
Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease.
Coronary Artery Disease
Lack of association between CYP1A1 T6235C polymorphism and coronary artery disease: evidence from a meta-analysis.
Coronary Artery Disease
Meta-Analysis of Cytochrome P450 2C19 Polymorphism and Risk of Adverse Clinical Outcomes Among Coronary Artery Disease Patients of Different Ethnic Groups Treated With Clopidogrel.
Coronary Artery Disease
Mutation in CYP27A1 identified in family with coronary artery disease.
Coronary Artery Disease
Polymorphism rs2762939 of CYP24A1 enzyme and coronary artery disease: angiographic results from a large prospective cohort of patients.
Coronary Artery Disease
Polymorphisms of cytochrome P450 1A1, cigarette smoking and risk of coronary artery disease.
Coronary Artery Disease
Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking.
Coronary Artery Disease
Relationship between cytochrome P450 2C19*17 genotype distribution, platelet aggregation and bleeding risk in patients with blood stasis syndrome of coronary artery disease treated with clopidogrel.
Coronary Artery Disease
Relationship between rs4674344 CYP27A1 gene polymorphism and coronary artery disease in a Polish population.
Coronary Artery Disease
Response to clopidogrel and of the cytochrome CYP2C19 gene polymorphism.
Coronary Artery Disease
Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.
Coronary Artery Disease
Role of CYP1A1 haplotypes in modulating susceptibility to coronary artery disease.
Coronary Artery Disease
Simvastatin intolerance genetic determinants: some features in ethnic Uzbek patients with coronary artery disease.
Coronary Artery Disease
Smoking-gene interaction and disease development: relevance to pancreatic cancer and atherosclerosis.
Coronary Artery Disease
The association between CYP1A1 genetic polymorphisms and coronary artery disease in the Uygur and Han of China.
Coronary Artery Disease
The CYP2C19 genotype does not impact the long-term prognosis of patients with coronary artery disease.
Coronary Artery Disease
[Association analysis of gene polymorphism in alcohol metabolizing enzymes with risk for coronary atherosclerosis]
Coronary Artery Disease
[Association between CYP1A1 genetic polymorphisms and coronary artery disease in Uygur population in Xinjiang, China].
Coronary Artery Disease
[Association of the MspI polymorphism of cytochrome P4501A1 gene and smoking to the susceptibility to coronary artery disease]
Coronary Artery Disease
[Relationship between ATP-binding cassette subfamily B member 1 and cytochrome P450 2C19 polymorphisms and the effect of clopidogrel post percutaneous coronary intervention in patients with acute coronary syndrome].
Coronary Disease
Association between CYP2C19*2/*3 Polymorphisms and Coronary Heart Disease.
Coronary Disease
Association of cytochrome P450 2C19 polymorphisms with coronary heart disease risk: A protocol for systematic review and meta analysis.
Coronary Disease
Contribution of CYP24A1 variants in coronary heart disease among the Chinese population.
Coronary Disease
CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndromes patients.
Coronary Disease
CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study.
Coronary Disease
Cytochrome P450 2C19*2 polymorphism in patients with stable coronary heart disease and risk for secondary cardiovascular disease events: results of a long-term follow-up study in routine clinical care.
Coronary Disease
Diversity of platelet function and genetic polymorphism in clopidogrel-treated Chinese patients.
Coronary Disease
Effect of Cytochrome P450 Family 2 Subfamily R Member 1 Variants on the Predisposition of Coronary Heart Disease in the Chinese Han Population.
Coronary Disease
Genotype Frequencies of CYP2C19, P2Y12 and GPIIIa Polymorphisms in Coronary Heart Disease Patients of Han Ethnicity, and Their Impact on Clopidogrel Responsiveness.
Coronary Disease
Identification of a CYP19 Gene Single-Nucleotide Polymorphism Associated with a Reduced Risk of Coronary Heart Disease.
Coronary Disease
Pharmacogenetic testing by polymorphic markers G1846A (CYP2D6*4) and C100T (CYP2D6*10) of the CYP2D6 gene in coronary heart disease patients taking ??-blockers in the Republic of Sakha (YAKUTIA).
Coronary Disease
Polymorphisms of CYP2C8, CYP2C9 and CYP2C19 and risk of coronary heart disease in Russian population.
Coronary Disease
Role of CYP1A1 (T6235C) polymorphism and cigarette smoking in the development of coronary heart disease in Tunisian population.
Coronary Disease
The association study between CYP20A1, CYP4F2, CYP2D6 gene polymorphisms and coronary heart disease risk in the Han population in southern China.
Coronary Stenosis
Effects of epoxyeicosatrienoic acids on polymorphonuclear leukocyte function.
Cough
Analysis of dextrorphan, a metabolite of dextromethorphan, using gas chromatography with electron-capture detection.
Cough
Effects of Ephedra Water Decoction and Cough Tablets containing Ephedra and Liquorice on CYP1A2 and the Pharmacokinetics of Theophylline in Rats.
Cough
Ephedra water decoction and cough tablets containing ephedra and liquorice induce CYP1A2 but not CYP2E1 hepatic enzymes in rats.
COVID-19
Clinically Significant Drug Interactions Between Psychotropic Agents and Repurposed COVID-19 Therapies.
COVID-19
CYP2D6 and CYP3A4 variants influence the risk and outcome of COVID-19 infection among rheumatoid arthritis patients maintained on hydroxychloroquine.
COVID-19
Drug-drug interactions between COVID-19 treatments and antipsychotics drugs: integrated evidence from 4 databases and a systematic review.
COVID-19
First-Degree Atrioventricular Block with Tachycardia from Paliperidone and Mirtazapine Overdose.
COVID-19
Genetic Polymorphisms Complicate COVID-19 Therapy: Pivotal Role of HO-1 in Cytokine Storm.
COVID-19
Impact of SARS-CoV-2 Infection (COVID-19) on Cytochromes P450 Activity Assessed by the Geneva Cocktail.
Craniocerebral Trauma
Head injury and cytochrome P-450 enzymes. Differential effect on mRNA and protein expression in the Fischer-344 rat.
Craniocerebral Trauma
Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration.
Craniofacial Abnormalities
Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations.
Crohn Disease
Genetic polymorphisms in biotransformation enzymes in Crohn's disease: association with microsomal epoxide hydrolase.
Crohn Disease
Iatrogenic cushing syndrome secondary to a probable interaction between voriconazole and budesonide.
Crohn Disease
Iatrogenic Cushing's syndrome related to the interaction between oral budesonide with fluvoxamine: a case report.
Crohn Disease
Polymorphism in the Retinoic Acid Metabolizing Enzyme CYP26B1 and the Development of Crohn's Disease.
Cryptococcosis
In Silico Structural Modeling and Analysis of Interactions of Tremellomycetes Cytochrome P450 Monooxygenases CYP51s with Substrates and Azoles.
Cryptorchidism
Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadias.
Cryptorchidism
Expression of anti-Müllerian hormone, CDKN1B, connexin 43, androgen receptor and steroidogenic enzymes in the equine cryptorchid testis.
Cushing Syndrome
Adrenal Insufficiency With Voriconazole and Inhaled/Intranasal Corticosteroids: Case Report and Systematic Review.
Cushing Syndrome
Aminoglutethimide suppresses adrenocorticotropin receptor expression in the NCI-h295 adrenocortical tumor cell line.
Cushing Syndrome
Cushing syndrome and severe adrenal suppression caused by fluticasone and protease inhibitor combination in an HIV-infected adolescent.
Cushing Syndrome
Effects of Ketoconazole on the Pharmacokinetics of Mifepristone, a Competitive Glucocorticoid Receptor Antagonist, in Healthy Men.
Cushing Syndrome
Fluticasone furoate induced iatrogenic Cushing syndrome in a pediatric patient receiving anti-retroviral therapy.
Cushing Syndrome
Iatrogenic Cushing syndrome due to drug interaction between inhaled fluticasone and cobicistat.
Cushing Syndrome
Iatrogenic Cushing Syndrome from Interaction Between Ritonavir and Oral Budesonide During Direct Acting Antiviral Hepatitis C Therapy.
Cushing Syndrome
Iatrogenic Cushing's syndrome related to the interaction between oral budesonide with fluvoxamine: a case report.
Cushing Syndrome
Inhaled budesonide induced Cushing's syndrome in cystic fibrosis patients, due to drug inhibition of cytochrome P450.
Cushing Syndrome
Preventing Cushing: Iatrogenic Cushing Syndrome due to Ritonavir-Fluticasone Interaction.
Cushing Syndrome
Ritonavir and Topical Ocular Corticosteroid Induced Cushing's Syndrome in an Adolescent with HIV-1 Infection.
Cystic Fibrosis
Activities of cytochrome P450 1A2, N-acetyltransferase 2, xanthine oxidase, and cytochrome P450 2D6 are unaltered in children with cystic fibrosis.
Cystic Fibrosis
An unusual cause of growth failure in cystic fibrosis: A salutary reminder of the interaction between glucocorticoids and cytochrome P450 inhibiting medication.
Cystic Fibrosis
Cytochrome P450 3A4 induction: lumacaftor versus ivacaftor potentially resulting in significantly reduced plasma concentration of ivacaftor.
Cystic Fibrosis
Disposition of drugs in cystic fibrosis. V. In vivo CYP2C9 activity as probed by (S)-warfarin is not enhanced in cystic fibrosis.
Cystic Fibrosis
Disposition of drugs in cystic fibrosis. VI. In vivo activity of cytochrome P450 isoforms involved in the metabolism of (R)-warfarin (including P450 3A4) is not enhanced in cystic fibrosis.
Cystic Fibrosis
Effect of cytochrome P450 2C19 genotype on voriconazole exposure in cystic fibrosis lung transplant patients.
Cystic Fibrosis
Impact of CYP3A5 phenotype on tacrolimus concentrations after sublingual and oral administration in lung transplant.
Cystic Fibrosis
Inhaled budesonide induced Cushing's syndrome in cystic fibrosis patients, due to drug inhibition of cytochrome P450.
Cystic Fibrosis
Pharmacokinetic interactions between ivacaftor and cytochrome P450 3A4 inhibitors in people with cystic fibrosis and healthy controls.
Cystic Fibrosis
Population pharmacokinetic modelling and design of a bayesian estimator for therapeutic drug monitoring of tacrolimus in lung transplantation.
Cystic Fibrosis
[Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases]
Cystinuria
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
Cystinuria
[Molecular and genetic technologies for the diagnosis of monogenic forms of urinary stone disease: clinical cases].
Cystitis
Plausible drug interaction between cyclophosphamide and voriconazole via inhibition of CYP2B6.
Cystitis
The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell Transplantation.
Cystitis, Interstitial
Differentiation associated changes in gene expression profiles of interstitial cystitis and control urothelial cells.
Cysts
CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women.
Cysts
RASopathic comedo-like or cystic lesions induced by Vemurafenib: A model of skin lesions similar but not identical to those induced by dioxins (MADISH).
Cysts
Spatially heterogeneous expression of aromatase P450 through promoter II is closely correlated with the level of steroidogenic factor-1 transcript in endometrioma tissues.
Cysts
Supraphysiological leptin levels shift the profile of steroidogenesis in porcine ovarian follicles toward progesterone and testosterone secretion through increased expressions of CYP11A1 and 17?-HSD: a tissue culture approach.
Cysts
The human Ah receptor: hints from dioxin toxicities to deregulated target genes and physiologic functions.
Dandruff
Cloning and Expression in Pichia pastoris of a New Cytochrome P450 Gene from a Dandruff-causing Malassezia globosa.
Death, Sudden, Cardiac
Advantages of azithromycin over erythromycin in improving the gastric emptying half-time in adult patients with gastroparesis.
Dehydration
Alteration of P450 distal pocket solvent leads to impaired proton delivery and changes in heme geometry.
Dehydration
Dehydration of alkyl- and arylaldoximes as a new cytochrome P450-catalyzed reaction: mechanism and stereochemical characteristics.
Dehydration
Effects of glucose supplementation on the pharmacokinetics of intravenous chlorzoxazone in rats with water deprivation for 72 h.
Dehydration
Effects of water deprivation on drug pharmacokinetics: correlation between drug metabolism and hepatic CYP isozymes.
Dehydration
Elicitor-induced association of isoflavone O-methyltransferase with endomembranes prevents the formation and 7-O-methylation of daidzein during isoflavonoid phytoalexin biosynthesis.
Dehydration
Fatty acid dioxygenase-cytochrome P450 fusion enzymes of filamentous fungal pathogens.
Dehydration
Fatty acid dioxygenase-cytochrome P450 fusion enzymes of the top 10 fungal pathogens in molecular plant pathology and human-pathogenic fungi.
Dehydration
Identification of genes associated with stress tolerance in moth bean [Vigna aconitifolia (Jacq.) Marechal], a stress hardy crop.
Dehydration
Lidocaine elimination and monoethylglycinexylidide formation in the dehydrated camel.
Dehydration
Mechanism of cytochrome P4503A4- and 2D6-catalyzed dehydrogenation of ezlopitant as probed with isotope effects using five deuterated analogs.
Dehydration
Pharmacokinetics of intravenous chlorzoxazone in rats with dehydration and rehydration: effects of food intakes.
Delirium
Delirium in a patient with toxic flecainide plasma concentrations: the role of a pharmacokinetic drug interaction with paroxetine.
Delirium
Delirium resolving upon switching from risperidone to quetiapine: implication of CYP2D6 genotype.
Delirium
Factors Predisposing to Coma and Delirium: Fentanyl and Midazolam Exposure; CYP3A5, ABCB1, and ABCG2 Genetic Polymorphisms; and Inflammatory Factors*.
Dementia
Clinical Response to Donepezil in Mild and Moderate Dementia: Relationship to Drug Plasma Concentration and CYP2D6 and APOE Genetic Polymorphisms.
Dementia
CYP2D6 gene polymorphism as a probable risk factor for Alzheimer's disease and Parkinson's disease with dementia.
Dementia
CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy Bodies or Alzheimer's disease.
Dementia
CYP2D6 polymorphisms in Alzheimer's disease, with and without extrapyramidal signs, showing no apolipoprotein E epsilon 4 effect modification.
Dementia
CYP2D6 Predicts Plasma Donepezil Concentrations in a Cohort of Thai Patients with Mild to Moderate Dementia.
Dementia
Cytochrome P450 (CYP450) Interactions Involving Atypical Antipsychotics are Common in Community-Dwelling Older Adults Treated for Behavioral and Psychological Symptoms of Dementia.
Dementia
Cytochrome P450 2D6 Phenotyping in an Elderly Population With Dementia and Response to Galantamine in Dementia: A Pilot Study.
Dementia
Genetic Editing and Pharmacogenetics in Current And Future Therapy Of Neurocognitive Disorders.
Dementia
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Dementia
Influence of Pathogenic and Metabolic Genes on the Pharmacogenetics of Mood Disorders in Alzheimer's Disease.
Dementia
Molecular pathology and pharmacogenomics in Alzheimer's disease: Polygenic-related effects of multifactorial treatments on cognition, anxiety and depression.
Dementia
No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian population.
Dementia
No evidence of an association between CYP2D6 polymorphisms among Japanese and dementia with Lewy bodies.
Dementia
Pharmacogenomics of Cognitive Dysfunction and Neuropsychiatric Disorders in Dementia.
Dementia
[Is it personalized treatment of dementia based on the CYP2D6 gene polymorphism possible?]
Dementia, Vascular
Influence of CYP2D6, CYP3A5, ABCB1, APOE polymorphisms and nongenetic factors on donepezil treatment in patients with Alzheimer's disease and vascular dementia.
Dengue
Insecticide resistance and underlying targets-site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistan.
Dengue
Molecular cloning and xenobiotic induction of seven novel cytochrome P450 monooxygenases in Aedes albopictus.
Dengue
Pyrethroid Resistance in Malaysian Populations of Dengue Vector Aedes aegypti Is Mediated by CYP9 Family of Cytochrome P450 Genes.
Dengue
The Cytochrome P450 gene CYP6P12 confers pyrethroid resistance in kdr-free Malaysian populations of the dengue vector Aedes albopictus.
Dent Disease
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
deoxyguanosine kinase deficiency
Targeted Next-Generation Sequencing in Diagnostic Approach to Monogenic Cholestatic Liver Disorders-Single-Center Experience.
Dermatitis
Decreased lymphocyte aryl hydrocarbon hydroxylase and glutathione S-transferase activities in patients with hand dermatitis.
Dermatitis
Trichloroethylene-induced hypersensitivity dermatitis was associated with hepatic metabolic enzyme genes and immune-related genes.
Dermatitis
[Relationship between gene polymorphism of CYP2E1, CYP1A1, IL-4 and medicamentosa-like der-matitis induced by trichloroethylene.]
Dermatitis, Allergic Contact
Decreased lymphocyte aryl hydrocarbon hydroxylase and glutathione S-transferase activities in patients with hand dermatitis.
Dermatitis, Atopic
A Promoter Polymorphism of the Vitamin D Metabolism Gene Cyp24a1 is Associated with Severe Atopic Dermatitis in Adults.
Dermatitis, Atopic
A rare variant in CYP27A1 and its association with atopic dermatitis with high serum total IgE.
Dermatitis, Atopic
Aryl hydrocarbon receptor expression in serum, peripheral blood mononuclear cells, and skin lesions of patients with atopic dermatitis and its correlation with disease severity.
Dermatitis, Atopic
Evaluation of Potential Disease-Mediated Drug-Drug Interaction in Patients With Moderate-to-Severe Atopic Dermatitis Receiving Dupilumab.
Dermatitis, Contact
17(S),18(R)-epoxyeicosatetraenoic acid generated by cytochrome P450 BM-3 from Bacillus megaterium inhibits the development of contact hypersensitivity via G-protein-coupled receptor 40-mediated neutrophil suppression.
Dermatitis, Contact
Cytochrome P450 1B1: a major P450 isoenzyme in human blood monocytes and macrophage subsets.
Dermatitis, Contact
Metabolic requirements for induction of contact hypersensitivity to immunotoxic polyaromatic hydrocarbons.
Dermatitis, Contact
Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1.
Dermatitis, Phototoxic
Major furocoumarins in grapefruit juice II: Phototoxicity, photogenotoxicity, and inhibitory potency vs. cytochrome P450 3A4 activity.
Dermatitis, Phototoxic
Single-step phototoxic selection procedure for isolating cells that possess aryl hydrocarbon hydroxylase.
Dermoid Cyst
Genetics of Congenital Corneal Opacification-Impact on Diagnosis and Treatment.
Diabetes Mellitus
A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese.
Diabetes Mellitus
Association Between the CYP2C9 Genotype and Hypoglycemia Among Patients With Type 2 Diabetes Receiving Sulfonylurea Treatment: A Meta-analysis.
Diabetes Mellitus
Association of CYP19A1 and CYP1A2 genetic polymorphisms with type 2 diabetes mellitus risk in the Chinese Han population.
Diabetes Mellitus
Association of Cytochrome P450 Genetic Variants with Clopidogrel Resistance and Outcomes in Acute Ischemic Stroke.
Diabetes Mellitus
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Diabetes Mellitus
Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration.
Diabetes Mellitus
Clopidogrel utilization in patients with coronary artery disease and diabetes mellitus: should we determine CYP2C19*2 genotype?
Diabetes Mellitus
Comparing the protective effects of three sulfur compounds against acrylonitrile-induced acute toxicity in CYP2E1-induced rats.
Diabetes Mellitus
Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism.
Diabetes Mellitus
CYP2C19 or CYP3A5 Genotyping Does Not Predict Clinical Response to Clopidogrel.
Diabetes Mellitus
Cytochrome P450 2C9 *2 and *3 polymorphisms and the dose and effect of sulfonylurea in type II diabetes mellitus.
Diabetes Mellitus
Derivation, Validation, and Prognostic Utility of a Prediction Rule for Nonresponse to Clopidogrel: The ABCD-GENE Score.
Diabetes Mellitus
Design, synthesis, biological evaluation and molecular dynamics studies of 4-thiazolinone derivatives as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
Diabetes Mellitus
Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans.
Diabetes Mellitus
Distribution of CYP2C8 and CYP2C9 amino acid substitution alleles in South Indian diabetes patients: A genotypic and computational protein phenotype study.
Diabetes Mellitus
Effect of CYP2C9 polymorphisms on prescribed dose and time-to-stable dose of sulfonylureas in primary care patients with Type 2 diabetes mellitus.
Diabetes Mellitus
Effect of type 2 diabetes mellitus on the pharmacokinetics and transplacental transfer of nifedipine in hypertensive pregnant women.
Diabetes Mellitus
Effects of Diabetes Mellitus on the Disposition of Tofacitinib, a Janus Kinase Inhibitor, in Rats.
Diabetes Mellitus
Evaluating the impact of type 2 diabetes mellitus on CYP450 metabolic activities: protocol for a case-control pharmacokinetic study.
Diabetes Mellitus
Evaluation of the Associations of GC and CYP2R1 Genes and Gene-Obesity Interactions with Type 2 Diabetes Risk in a Chinese Rural Population.
Diabetes Mellitus
Evaluation of the influence of diabetes mellitus on antipyrine metabolism and CYP1A2 and CYP2D6 activity.
Diabetes Mellitus
Frequency of CYP2C9 (*2, *3 and IVS8-109A>T) allelic variants, and their clinical implications, among Mexican patients with diabetes mellitus type 2 undergoing treatment with glibenclamide and metformin.
Diabetes Mellitus
Genetic Polymorphisms of Cytochrome p450 (2C9) Enzyme in Patients with Type 2 Diabetes Mellitus in Turkmen and Fars Ethnic Groups.
Diabetes Mellitus
In Silico Computations Of Selective Phytochemicals As Potential Inhibitors Against Major Biological Targets Of Diabetes Mellitus.
Diabetes Mellitus
Influence of CYP2C9 gene polymorphisms on response to glibenclamide in type 2 diabetes mellitus patients.
Diabetes Mellitus
Influence of genetic polymorphisms of CYP3A5 and ABCB1 on sirolimus pharmacokinetics, patient and graft survival and other clinical outcomes in renal transplant.
Diabetes Mellitus
Lymphocyte cytochrome P450 expression: inducibility studies in male Wistar rats.
Diabetes Mellitus
Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.
Diabetes Mellitus
Non-alcoholic Steatohepatitis (NASH) Drug Discovery - Building a Consensus on ADME Screening Tools and Clinical Pharmacology Strategies to Aid Candidate Development.
Diabetes Mellitus
Pharmacokinetic parameters of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, after intravenous and oral administration of chlorzoxazone to liver cirrhotic rats with diabetes mellitus.
Diabetes Mellitus
Pharmacokinetics of drugs in rats with diabetes mellitus induced by alloxan or streptozocin: comparison with those in patients with type I diabetes mellitus.
Diabetes Mellitus
Pharmacokinetics of theophylline in diabetes mellitus rats: induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation.
Diabetes Mellitus
Risk factors for post-transplant diabetes mellitus in renal transplant: Role of genetic variability in the CYP450-mediated arachidonic acid metabolism.
Diabetes Mellitus
Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus.
Diabetes Mellitus
The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects.
Diabetes Mellitus
The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPAR? on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes.
Diabetes Mellitus
Transcriptomic profiling as biological markers of depression - A pilot study in unipolar and bipolar women.
Diabetes Mellitus
Trigonella stellata reduced the deleterious effects of diabetes mellitus through alleviation of oxidative stress, antioxidant- and drug-metabolizing enzymes activities.
Diabetes Mellitus
[Maximal initial dose of simvastatin causing acute renal failure through rhabdomyolysis: risk factors, pathomechanism and therapy related to a case]
Diabetes Mellitus
[Perfusion and metabolism of liver and splanchnic nerve area under sevoflurane anesthesia]
Diabetes Mellitus, Experimental
Induction and suppression of renal and hepatic cytochrome P450-dependent monooxygenases by acute and chronic streptozotocin diabetes in hamsters.
Diabetes Mellitus, Experimental
[Status of the monooxygenase enzyme system in rat and rabbit organs in sugar diabetes and upon insulin administration]
Diabetes Mellitus, Type 1
Association of increased renal Cyp24a1 gene expression with low plasma 1,25-dihydroxyvitamin D levels in rats with streptozotocin-induced diabetes.
Diabetes Mellitus, Type 1
Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes.
Diabetes Mellitus, Type 1
Cytochrome P450IIE1 is elevated in lymphocytes from poorly controlled insulin-dependent diabetics.
Diabetes Mellitus, Type 1
EETs/sEH in diabetes and obesity-induced cardiovascular diseases.
Diabetes Mellitus, Type 1
Evaluation of the influence of diabetes mellitus on antipyrine metabolism and CYP1A2 and CYP2D6 activity.
Diabetes Mellitus, Type 1
Extrahepatic expression of P450 proteins in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Lymphocyte cytochrome P450-CYP2E1 expression in human IDDM subjects.
Diabetes Mellitus, Type 1
Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.
Diabetes Mellitus, Type 1
Taurine Is More Effective than Melatonin on Cytochrome P450 2E1 and Some Oxidative Stress Markers in Streptozotocin-Induced Diabetic Rats.
Diabetes Mellitus, Type 1
Tissue-specific effect of ascorbic acid supplementation on the expression of cytochrome P450 2E1 and oxidative stress in streptozotocin-induced diabetic rats.
Diabetes Mellitus, Type 1
Viral triggers for autoimmunity: Is the 'glass of molecular mimicry' half full or half empty?
Diabetes Mellitus, Type 1
Vitamin D Pathway Genetic Variation and Type 1 Diabetes: A Case-Control Association Study.
Diabetes Mellitus, Type 1
[Vitamin D3 availability and functional activity of peripheral blood phagocytes in experimental type 1 diabetes].
Diabetes Mellitus, Type 2
A Pilot Study towards the Impact of Type 2 Diabetes on the Expression and Activities of Drug Metabolizing Enzymes and Transporters in Human Duodenum.
Diabetes Mellitus, Type 2
A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese.
Diabetes Mellitus, Type 2
Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria.
Diabetes Mellitus, Type 2
Analysis of CYP2C9*2, CYP2C19*2, and CYP2D6*4 polymorphisms in patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Androgen receptor overexpression in prostate cancer in type 2 diabetes.
Diabetes Mellitus, Type 2
Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study.
Diabetes Mellitus, Type 2
Association Between the CYP2C9 Genotype and Hypoglycemia Among Patients With Type 2 Diabetes Receiving Sulfonylurea Treatment: A Meta-analysis.
Diabetes Mellitus, Type 2
Association of a polymorphism of CYP3A4 with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Association of CYP19A1 and CYP1A2 genetic polymorphisms with type 2 diabetes mellitus risk in the Chinese Han population.
Diabetes Mellitus, Type 2
Association of troglitazone-induced liver injury with mutation of the cytochrome P450 2C19 gene.
Diabetes Mellitus, Type 2
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Diabetes Mellitus, Type 2
Calpain-10 gene polymorphisms and type 2 diabetes in West Africans: the Africa America Diabetes Mellitus (AADM) Study.
Diabetes Mellitus, Type 2
Chronic Inflammatory Status Observed in Patients with Type 2 Diabetes Induces Modulation of Cytochrome P450 Expression and Activity.
Diabetes Mellitus, Type 2
Coffee intake and risk of obesity, metabolic syndrome and type 2 diabetes: a Mendelian randomization study.
Diabetes Mellitus, Type 2
CYP2C19 or CYP3A5 Genotyping Does Not Predict Clinical Response to Clopidogrel.
Diabetes Mellitus, Type 2
CYP2C8 and SLCO1B1 Variants and Therapeutic Response to Thiazolidinediones in Patients With Type 2 Diabetes.
Diabetes Mellitus, Type 2
CYP2C9*3 gene variant contributes independently to glycaemic control in patients with type 2 diabetes treated with glibenclamide.
Diabetes Mellitus, Type 2
CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients.
Diabetes Mellitus, Type 2
Design, synthesis, biological evaluation and molecular dynamics studies of 4-thiazolinone derivatives as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
Diabetes Mellitus, Type 2
Distribution of CYP2C8 and CYP2C9 amino acid substitution alleles in South Indian diabetes patients: A genotypic and computational protein phenotype study.
Diabetes Mellitus, Type 2
EETs/sEH in diabetes and obesity-induced cardiovascular diseases.
Diabetes Mellitus, Type 2
Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes.
Diabetes Mellitus, Type 2
Effect of CYP2C9 genetic polymorphisms on the efficacy and pharmacokinetics of glimepiride in subjects with type 2 diabetes.
Diabetes Mellitus, Type 2
Effect of CYP2C9 polymorphisms on prescribed dose and time-to-stable dose of sulfonylureas in primary care patients with Type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Effects of type 1 and type 2 diabetes on the pharmacokinetics of tramadol enantiomers in patients with neuropathic pain phenotyped as cytochrome P450 2D6 extensive metabolizers.
Diabetes Mellitus, Type 2
Evaluating the effect of type 2 diabetes mellitus on CYP450 enzymes and P-gp activities, before and after glycemic control: A protocol for a case-control pharmacokinetic study.
Diabetes Mellitus, Type 2
Evaluating the impact of type 2 diabetes mellitus on CYP450 metabolic activities: protocol for a case-control pharmacokinetic study.
Diabetes Mellitus, Type 2
Evaluation of the Associations of GC and CYP2R1 Genes and Gene-Obesity Interactions with Type 2 Diabetes Risk in a Chinese Rural Population.
Diabetes Mellitus, Type 2
Evaluation of the pharmacokinetic interaction between the dipeptidyl peptidase-4 inhibitor linagliptin and pioglitazone in healthy volunteers.
Diabetes Mellitus, Type 2
Genetic analysis of the NAT2 and CYP2D6 polymorphisms in white patients with non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Genetic Polymorphisms of Cytochrome p450 (2C9) Enzyme in Patients with Type 2 Diabetes Mellitus in Turkmen and Fars Ethnic Groups.
Diabetes Mellitus, Type 2
Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History.
Diabetes Mellitus, Type 2
Half-Life of Sulfonylureas in HNF1A and HNF4A Human MODY Patients is not Prolonged as Suggested by the Mouse Hnf1a(-/-) Model.
Diabetes Mellitus, Type 2
Identification of genes and pathways in esophageal adenocarcinoma using bioinformatics analysis.
Diabetes Mellitus, Type 2
Identification of key genes involved in type 2 diabetic islet dysfunction: a bioinformatics study.
Diabetes Mellitus, Type 2
Influence of CYP2C9 gene polymorphisms on response to glibenclamide in type 2 diabetes mellitus patients.
Diabetes Mellitus, Type 2
Influence of SLCO1B1 and CYP2C8 gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteers.
Diabetes Mellitus, Type 2
Inhibitory effects of type 2 diabetes serum components in P450 inhibition assays can potential diagnose asymptomatic diabetic mice.
Diabetes Mellitus, Type 2
Interaction between heavy smoking and CYP2A6 genotypes on type 2 diabetes and its possible pathways.
Diabetes Mellitus, Type 2
Loss-of-Function CYP2C9 Variants Improve Therapeutic Response to Sulfonylureas in Type 2 Diabetes: A Go-DARTS Study.
Diabetes Mellitus, Type 2
Loss-of-function CYP2C9 variants: finding the correct clinical role for Type 2 diabetes pharmacogenetic testing.
Diabetes Mellitus, Type 2
Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation: Findings From the Pregnancy and Childhood Epigenetics Consortium.
Diabetes Mellitus, Type 2
Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity.
Diabetes Mellitus, Type 2
Modulation of CYP450 Activities in Patients With Type 2 Diabetes.
Diabetes Mellitus, Type 2
NAT2 polymorphism associated with plasma glucose concentration in Canadian Oji-Cree.
Diabetes Mellitus, Type 2
Non-alcoholic Steatohepatitis (NASH) Drug Discovery - Building a Consensus on ADME Screening Tools and Clinical Pharmacology Strategies to Aid Candidate Development.
Diabetes Mellitus, Type 2
Ovarian function in women with non-insulin dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Personalized medicine in diabetes: the role of 'omics' and biomarkers.
Diabetes Mellitus, Type 2
Pharmacodynamic Effect of Cilostazol Plus Standard Clopidogrel Versus Double-Dose Clopidogrel in Patients With Type 2 Diabetes Undergoing Percutaneous Coronary Intervention.
Diabetes Mellitus, Type 2
Sex differences in the effect of cytochrome P450 2C19 polymorphisms on the risk of diabetic retinopathy: a retrospective longitudinal study in Japanese patients with type 2 diabetes.
Diabetes Mellitus, Type 2
The CYP19 gene and associations with androgens and abdominal obesity in premenopausal women.
Diabetes Mellitus, Type 2
The Effect of CYP2C9 Genotype Variants in Type 2 Diabetes on the Pharmacological Effectiveness of Sulfonylureas, Diabetic Retinopathy, and Nephropathy.
Diabetes Mellitus, Type 2
The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects.
Diabetes Mellitus, Type 2
The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPAR? on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes.
Diabetes Mellitus, Type 2
Thiazolidinediones for type 2 diabetes. No evidence exists that pioglitazone induces hepatic cytochrome P450 isoform CYP3A4.
Diabetes Mellitus, Type 2
Use of 4?-Hydroxycholesterol Plasma Concentrations as an Endogenous Biomarker of CYP3A Activity: Clinical Validation in Individuals With Type 2 Diabetes.
Diabetes Mellitus, Type 2
Vitamin D in Type 2 Diabetes: Genetic Susceptibility and the Response to Supplementation.
Diabetes, Gestational
Hypoglycemia and Glycemic Control With Glyburide in Women With Gestational Diabetes and Genetic Variants of Cytochrome P450 2C9 and/or OATP1B3.
Diabetes, Gestational
Knockdown of CYP1B1 suppresses the behavior of the extravillous trophoblast cell line HTR-8/SVneo under hyperglycemic condition.
Diabetes, Gestational
Placenta expression of vitamin D and related genes in pregnant women with gestational diabetes mellitus.
Diabetes, Gestational
The Role of Arachidonic and Linoleic Acid Derivatives in Pathological Pregnancies and the Human Reproduction Process.
Diabetic Cardiomyopathies
Role of Cytochrome p450 and Soluble Epoxide Hydrolase Enzymes and Their Associated Metabolites in the Pathogenesis of Diabetic Cardiomyopathy.
Diabetic Nephropathies
CYP24A1 exacerbated activity during diabetes contributes to kidney tubular apoptosis via caspase-3 increased expression and activation.
Diabetic Nephropathies
Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone.
Diabetic Nephropathies
Involvement of renal cytochromes P450 and arachidonic acid metabolites in diabetic nephropathy.
Diabetic Nephropathies
Targeted CYP2E1 quantification and its correlation to currently acceptable clinical biochemical indices.
Diabetic Nephropathies
Targeting oxidative stress and anti-oxidant defence in diabetic kidney disease.
Diabetic Neuropathies
Duloxetine: new indication. Depression and diabetic neuropathy: too many adverse effects.
Diabetic Retinopathy
Sex differences in the effect of cytochrome P450 2C19 polymorphisms on the risk of diabetic retinopathy: a retrospective longitudinal study in Japanese patients with type 2 diabetes.
Diabetic Retinopathy
The Effect of CYP2C9 Genotype Variants in Type 2 Diabetes on the Pharmacological Effectiveness of Sulfonylureas, Diabetic Retinopathy, and Nephropathy.
Diabetic Retinopathy
[Behavior of the olfactive function in patients affected by diabetic retinopathies]
DiGeorge Syndrome
A Case of 22q11.2 Deletion Syndrome with Peters Anomaly, Congenital Glaucoma, and Heterozygous Mutation in CYP1B1.
Digestive System Neoplasms
Characteristic CYP2A6 genetic polymorphisms detected by TA cloning-based sequencing in Chinese digestive system cancer patients with S-1 based chemotherapy.
Digestive System Neoplasms
Functional polymorphisms in the CYP2C19 gene contribute to digestive system cancer risk: evidence from 11,042 subjects.
Diplopia
Possible Genetic Determinants of Response to Phenytoin in a Group of Colombian Patients With Epilepsy.
Disorders of Excessive Somnolence
Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia.
Disorders of Sex Development
Evidence of endocrine alteration in the red mullet, Mullus barbatus from the NW Mediterranean.
Disorders of Sex Development
Hypothalamic-pituitary-ovarian axis during infancy, early and late prepuberty in an aromatase-deficient girl who is a compound heterocygote for two new point mutations of the CYP19 gene.
Disorders of Sex Development
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
Disorders of Sex Development
P450 Oxidoreductase deficiency: Analysis of mutations and polymorphisms.
Disorders of Sex Development
Sex differences in autophagy-mediated diseases: toward precision medicine.
Down Syndrome
Variants in CYP17 and CYP19 cytochrome P450 genes are associated with onset of Alzheimer's disease in women with down syndrome.
Drug Hypersensitivity
The metabolic rationale for a lack of cross-reactivity between sulfonamide antimicrobials and other sulfonamide-containing drugs.
Drug Hypersensitivity Syndrome
Presence of a single nucleotide polymorphism (RS3758581) in a boy with DRESS syndrome.
Drug Resistant Epilepsy
Influence of genetic variants of CYP2D6, CYP2C9, CYP2C19 and CYP3A4 on antiepileptic drug metabolism in pediatric patients with refractory epilepsy.
Drug Resistant Epilepsy
Possible role of CYP2C9 & CYP2C19 single nucleotide polymorphisms in drug refractory epilepsy.
Drug-Related Side Effects and Adverse Reactions
A candidate gene study of antiepileptic drug tolerability and efficacy identifies an association of CYP2C9 variants with phenytoin toxicity.
Drug-Related Side Effects and Adverse Reactions
A history of the roles of cytochrome P450 enzymes in the toxicity of drugs.
Drug-Related Side Effects and Adverse Reactions
A new simple diagnostic assay for the identification of the major CYP2D6 genotypes by DNA sequencing analysis.
Drug-Related Side Effects and Adverse Reactions
A Review of the Important Role of CYP2D6 in Pharmacogenomics.
Drug-Related Side Effects and Adverse Reactions
A service improvement project to review prescribing information provided by general practitioners for new referrals to a UK National Health Service hospital pain clinic: potential implications of CYP2D6 enzyme inhibition.
Drug-Related Side Effects and Adverse Reactions
A Single Site Population Study to Investigate CYP2D6 Phenotype of Patients with Persistent Non-Malignant Pain.
Drug-Related Side Effects and Adverse Reactions
Adverse drug reactions following nonresponse in a depressed patient with CYP2D6 deficiency and low CYP 3A4/5 activity.
Drug-Related Side Effects and Adverse Reactions
Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers.
Drug-Related Side Effects and Adverse Reactions
Allele and genotype frequencies of CYP2B6 in a Turkish population.
Drug-Related Side Effects and Adverse Reactions
Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages.
Drug-Related Side Effects and Adverse Reactions
An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics.
Drug-Related Side Effects and Adverse Reactions
An update on CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.
Drug-Related Side Effects and Adverse Reactions
Analysis of Elevated Levels of Nandrolone Decanoate Induced Cytochrome- P450 Alterations in Mice.
Drug-Related Side Effects and Adverse Reactions
Antipsychotic prescribing practices following withdrawal of concomitant carbamazepine.
Drug-Related Side Effects and Adverse Reactions
Application of support vector machines to in silico prediction of cytochrome p450 enzyme substrates and inhibitors.
Drug-Related Side Effects and Adverse Reactions
Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia.
Drug-Related Side Effects and Adverse Reactions
Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy.
Drug-Related Side Effects and Adverse Reactions
Associations of CYP2C9 and CYP2C19 Pharmacogenetic Variation with Phenytoin-Induced Cutaneous Adverse Drug Reactions.
Drug-Related Side Effects and Adverse Reactions
Autoantibodies against cytochrome P450s in sera of children treated with immunosuppressive drugs.
Drug-Related Side Effects and Adverse Reactions
Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins.
Drug-Related Side Effects and Adverse Reactions
Chimeric cytochrome P450 3A4 used for in vitro prediction of food-drug interactions.
Drug-Related Side Effects and Adverse Reactions
Clinical and toxicological relevance of CYP2C9: drug-drug interactions and pharmacogenetics.
Drug-Related Side Effects and Adverse Reactions
Clinical consequences of cytochrome P450 2C9 polymorphisms.
Drug-Related Side Effects and Adverse Reactions
Clinical evidence of pharmacokinetic changes in thalidomide therapy.
Drug-Related Side Effects and Adverse Reactions
Clinical Utility and Economic Impact of CYP2D6 Genotyping.
Drug-Related Side Effects and Adverse Reactions
Co-administration of statins with cytochrome P450 3A4 inhibitors in a UK primary care population.
Drug-Related Side Effects and Adverse Reactions
Compound I reactivity defines alkene oxidation selectivity in cytochrome P450cam.
Drug-Related Side Effects and Adverse Reactions
Correlation of CYP2B6, CYP2C19, ABCC4 and SOD2 genotype with outcomes in allogeneic blood and marrow transplant patients.
Drug-Related Side Effects and Adverse Reactions
CYP1B1 expression is induced by docetaxel: effect on cell viability and drug resistance.
Drug-Related Side Effects and Adverse Reactions
CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations-Implication for Drug Safety, Dosing, and Individualized Therapy.
Drug-Related Side Effects and Adverse Reactions
CYP2C9 and ABCG2 polymorphisms as risk factors for developing adverse drug reactions in renal transplant patients taking fluvastatin: a case-control study.
Drug-Related Side Effects and Adverse Reactions
CYP2C9 and CYP2C19 Allele and Haplotype Distributions in Four Mestizo Populations from Western Mexico: An Interethnic Comparative Study.
Drug-Related Side Effects and Adverse Reactions
CYP2C9 Genetic Polymorphism is a Potential Predictive Marker for the Efficacy of Rosuvastatin Therapy.
Drug-Related Side Effects and Adverse Reactions
CYP2D6 *6/*6 genotype and drug interactions as cause of haloperidol-induced extrapyramidal symptoms.
Drug-Related Side Effects and Adverse Reactions
CYP2D6 and Antipsychotic Treatment Outcomes in Children and Youth: A Systematic Review.
Drug-Related Side Effects and Adverse Reactions
CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies.
Drug-Related Side Effects and Adverse Reactions
CYP2D6 genotypes in Puerto Rican psychiatry patients with intolerance of antidepressants and antipsychotics.
Drug-Related Side Effects and Adverse Reactions
CYP2D6 genotypes in revolving door patients with bipolar disorders: A case series.
Drug-Related Side Effects and Adverse Reactions
CYP2D6 genotyping for psychiatric patients treated with risperidone: considerations for cost-effectiveness studies.
Drug-Related Side Effects and Adverse Reactions
CYP2D6 genotyping in paediatric patients with autism treated with risperidone: a preliminary cohort study.
Drug-Related Side Effects and Adverse Reactions
CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System-Results From the ADRED Study.
Drug-Related Side Effects and Adverse Reactions
CYP2D6 Metabolism in Frail Elderly Compared to Non-Frail Elderly: A Pilot Feasibility Study.
Drug-Related Side Effects and Adverse Reactions
CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload.
Drug-Related Side Effects and Adverse Reactions
Cytochrome P450 enzyme polymorphisms and adverse drug reactions.
Drug-Related Side Effects and Adverse Reactions
Cytochromes P450 and drug toxicity. Immunological consequences.
Drug-Related Side Effects and Adverse Reactions
Decreases in phenytoin hydroxylation activities catalyzed by liver microsomal cytochrome P450 enzymes in phenytoin-treated rats.
Drug-Related Side Effects and Adverse Reactions
Determination of CYP2D6, CYP2C9 and CYP2C19 genotypes with Tag-It mutation detection assays.
Drug-Related Side Effects and Adverse Reactions
Development and validation of a rapid and reliable real-time PCR method for CYP3A5 genotyping.
Drug-Related Side Effects and Adverse Reactions
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Drug-Related Side Effects and Adverse Reactions
Development of NanoART for HIV Treatment: Minding the Cytochrome P450 (CYP) Enzymes.
Drug-Related Side Effects and Adverse Reactions
Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes.
Drug-Related Side Effects and Adverse Reactions
Differential time-dependent inactivation of P450 3A4 and P450 3A5 by raloxifene: a key role for C239 in quenching reactive intermediates.
Drug-Related Side Effects and Adverse Reactions
Distribution of CYP2D6 and CYP2C19 Polymorphisms Associated with Poor Metabolizer Phenotype in Five Amerindian Groups and Western Mestizos from Mexico.
Drug-Related Side Effects and Adverse Reactions
Distribution of CYP2D6 polymorphism in the Middle Eastern region.
Drug-Related Side Effects and Adverse Reactions
Does obtaining CYP2D6 and CYP2C19 pharmacogenetic testing predict antidepressant response or adverse drug reactions?
Drug-Related Side Effects and Adverse Reactions
Drug extrapyramidal side effects. CYP2D6 genotypes and phenotypes.
Drug-Related Side Effects and Adverse Reactions
Drug extrapyramidal side-effects or not: is there a dextromethorphan phenotype difference?
Drug-Related Side Effects and Adverse Reactions
Drug metabolism genotypes and their association with adverse drug reactions in selected populations: a pilot study of methodology.
Drug-Related Side Effects and Adverse Reactions
Drug-drug interactions and cooperative effects detected in electrochemically driven human cytochrome P450 3A4.
Drug-Related Side Effects and Adverse Reactions
Drug-induced liver graft toxicity caused by cytochrome P450 poor metabolism.
Drug-Related Side Effects and Adverse Reactions
Drugs impact on CYP-450 enzyme family: A pharmacogenetical study of response variation.
Drug-Related Side Effects and Adverse Reactions
Dynamics and persistence of CYP2D6 inhibition by paroxetine.
Drug-Related Side Effects and Adverse Reactions
Efavirenz and CYP2B6 Polymorphism: Implications for Drug Toxicity and Resistance.
Drug-Related Side Effects and Adverse Reactions
Effect of sodium alterations on hepatic cytochrome P450 3A2 and 2C11 and renal function in rats.
Drug-Related Side Effects and Adverse Reactions
Effects of 24 CYP2D6 variants found in Chinese population on the metabolism of clonidine in vitro.
Drug-Related Side Effects and Adverse Reactions
Evaluation of 24 CYP2D6 Variants on the Metabolism of Nebivolol in vitro.
Drug-Related Side Effects and Adverse Reactions
Evaluation of Phenotypic and Genotypic Variations of Drug Metabolising Enzymes and Transporters in Chronic Pain Patients Facing Adverse Drug Reactions or Non-Response to Analgesics: A Retrospective Study.
Drug-Related Side Effects and Adverse Reactions
Evaluation of the Effects of Cytochrome P450 Non-synonymous Single-nucleotide Polymorphisms on DBZ Metabolism and Inhibition Potential.
Drug-Related Side Effects and Adverse Reactions
Expression of autoantibodies to specific cytochromes P450 in a case of disulfiram hepatitis.
Drug-Related Side Effects and Adverse Reactions
Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness.
Drug-Related Side Effects and Adverse Reactions
Factors affecting the development of adverse drug reactions to ?-blockers in hospitalized cardiac patient population.
Drug-Related Side Effects and Adverse Reactions
Fast Screening Technology for Drug Emergency Management: Predicting Suspicious SNPs for ADR with Information Theory-based Models.
Drug-Related Side Effects and Adverse Reactions
Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9.
Drug-Related Side Effects and Adverse Reactions
Frequency of mutated allele CYP2D6*4 in the Turkish population.
Drug-Related Side Effects and Adverse Reactions
From Genotype to Phenotype: Cytochrome P450 2D6-Mediated Drug Clearance in Humans.
Drug-Related Side Effects and Adverse Reactions
Functional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation Activities.
Drug-Related Side Effects and Adverse Reactions
Functional Characterization of Wild-type and 49 CYP2D6 Allelic Variants for N-desmethyltamoxifen 4-hydroxylation Activity.
Drug-Related Side Effects and Adverse Reactions
Functional role of Ile264 in CYP2C8: mutations affect haem incorporation and catalytic activity.
Drug-Related Side Effects and Adverse Reactions
Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia.
Drug-Related Side Effects and Adverse Reactions
Genetic polymorphism and toxicology--with emphasis on cytochrome p450.
Drug-Related Side Effects and Adverse Reactions
Genetic polymorphism of cytochrome P450 2C9 in diphenylhydantoin-induced cutaneous adverse drug reactions.
Drug-Related Side Effects and Adverse Reactions
Genetic polymorphisms of drug metabolism. Possible implications during development.
Drug-Related Side Effects and Adverse Reactions
Genetic predisposition to acute gastrointestinal bleeding after NSAIDs use.
Drug-Related Side Effects and Adverse Reactions
Genetic Variants of Cytochrome CYP2D6 in Two Mixed Chilean Populations.
Drug-Related Side Effects and Adverse Reactions
Genetics and variability in opioid response.
Drug-Related Side Effects and Adverse Reactions
Genome-based biomarkers for adverse drug effects, patient enrichment and prediction of drug response, and their incorporation into clinical trial design.
Drug-Related Side Effects and Adverse Reactions
Hepatic cytochrome P450 regulation in disease states.
Drug-Related Side Effects and Adverse Reactions
HMG-CoA reductase inhibitors: assessing differences in drug interactions and safety profiles.
Drug-Related Side Effects and Adverse Reactions
Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms.
Drug-Related Side Effects and Adverse Reactions
Human NAD(P)H:quinone Oxidoreductase 1 (NQO1)-Mediated Inactivation of Reactive Quinoneimine Metabolites of Diclofenac and Mefenamic Acid.
Drug-Related Side Effects and Adverse Reactions
Identification of CYP2D6 null variants among long-stay, chronic psychiatric inpatients: is it strictly necessary?
Drug-Related Side Effects and Adverse Reactions
Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance.
Drug-Related Side Effects and Adverse Reactions
Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia.
Drug-Related Side Effects and Adverse Reactions
Impact of Efavirenz Metabolism on Loss to Care in Older HIV+ Africans.
Drug-Related Side Effects and Adverse Reactions
Importance of cytochrome P450 (CYP450) in adverse drug reactions due to drug-drug interactions: a PharmacoVigilance study in France.
Drug-Related Side Effects and Adverse Reactions
In human therapy, is the drug-drug interaction or the adverse drug reaction the issue?
Drug-Related Side Effects and Adverse Reactions
In Silico Prediction of CYP2C8 Inhibition with Machine-Learning Methods.
Drug-Related Side Effects and Adverse Reactions
Inactivation of CYP3A4 by Benzbromarone in Human Liver Microsomes.
Drug-Related Side Effects and Adverse Reactions
Influence of short-term use of dexamethasone on the pharmacokinetics of ifosfamide in patients.
Drug-Related Side Effects and Adverse Reactions
Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals.
Drug-Related Side Effects and Adverse Reactions
Intravenous carbamazepine: a new formulation of a familiar drug.
Drug-Related Side Effects and Adverse Reactions
Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis.
Drug-Related Side Effects and Adverse Reactions
Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group.
Drug-Related Side Effects and Adverse Reactions
Long-term administration of escitalopram in patients with social anxiety disorder in Japan.
Drug-Related Side Effects and Adverse Reactions
Maternal-fetal and neonatal pharmacogenomics: a review of current literature.
Drug-Related Side Effects and Adverse Reactions
Measurement of voriconazole in serum and plasma.
Drug-Related Side Effects and Adverse Reactions
Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure-Activity Relationships and Discovery Strategies to Mitigate Drug-Drug Interaction Risks.
Drug-Related Side Effects and Adverse Reactions
Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions.
Drug-Related Side Effects and Adverse Reactions
Monoclonal antibodies specific and inhibitory to human cytochromes P450 2C8, 2C9, and 2C19.
Drug-Related Side Effects and Adverse Reactions
Multiple adverse drug reactions and genetic polymorphism testing: A case report with negative result.
Drug-Related Side Effects and Adverse Reactions
Multiplex genotyping of cytochrome p450 single-nucleotide polymorphisms by use of MALDI-TOF mass spectrometry.
Drug-Related Side Effects and Adverse Reactions
Neuroleptic malignant syndrome in an adolescent with CYP2D6 deficiency.
Drug-Related Side Effects and Adverse Reactions
New cytochrome P450 mechanisms: implications for understanding molecular basis for drug toxicity at the level of the cytochrome.
Drug-Related Side Effects and Adverse Reactions
No evidence of increased adverse drug reactions in cytochrome P450 CYP2D6 poor metabolizers treated with fluoxetine or nortriptyline.
Drug-Related Side Effects and Adverse Reactions
Optimising Seniors' Metabolism of Medications and Avoiding Adverse Drug Events Using Data on How Metabolism by Their P450 Enzymes Varies with Ancestry and Drug-Drug and Drug-Drug-Gene Interactions.
Drug-Related Side Effects and Adverse Reactions
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Drug-Related Side Effects and Adverse Reactions
Overcoming Taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin.
Drug-Related Side Effects and Adverse Reactions
Pharmacogenetic Prediction of Individual Variability in Drug Response Based on CYP2D6, CYP2C9 and CYP2C19 Genetic Polymorphisms.
Drug-Related Side Effects and Adverse Reactions
Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin.
Drug-Related Side Effects and Adverse Reactions
Pharmacogenetic testing of CYP2D6 in patients with aripiprazole-related extrapyramidal symptoms: a case-control study.
Drug-Related Side Effects and Adverse Reactions
Pharmacogenetics of Anticoagulation and Clinical Events in Warfarin-Treated Patients: A Register-Based Cohort Study with Biobank Data and National Health Registries in Finland.
Drug-Related Side Effects and Adverse Reactions
Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future.
Drug-Related Side Effects and Adverse Reactions
Pharmacogenetics: implementing personalized medicine.
Drug-Related Side Effects and Adverse Reactions
Physical Performance and Quality of Life in Older Adults: Is There Any Association between Them and Potential Drug Interactions in Polymedicated Octogenarians.
Drug-Related Side Effects and Adverse Reactions
Physiologically based pharmacokinetic (PBPK) modeling for prediction of celecoxib pharmacokinetics according to CYP2C9 genetic polymorphism.
Drug-Related Side Effects and Adverse Reactions
Physiologically Based Pharmacokinetic Modelling to Describe the Pharmacokinetics of Risperidone and 9-Hydroxyrisperidone According to Cytochrome P450 2D6 Phenotypes.
Drug-Related Side Effects and Adverse Reactions
Pitavastatin therapy in polymedicated patients is associated with a low risk of drug-drug interactions: analysis of real-world and phase 3 clinical trial data.
Drug-Related Side Effects and Adverse Reactions
Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance.
Drug-Related Side Effects and Adverse Reactions
Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I.
Drug-Related Side Effects and Adverse Reactions
Polymorphisms and phenotypic analysis of cytochrome P450 2D6 in the Tibetan population.
Drug-Related Side Effects and Adverse Reactions
Polymorphisms of CYP2C19 and CYP2D6 in Israeli ethnic groups.
Drug-Related Side Effects and Adverse Reactions
Prediction By Pharmacogenetics Of Safety And Efficacy Of Non-Steroidal Anti-Inflammatory Drugs: A Review.
Drug-Related Side Effects and Adverse Reactions
Prediction of human cytochrome P450 2B6-substrate interactions using hierarchical support vector regression approach.
Drug-Related Side Effects and Adverse Reactions
Prevalence of CYP2C9 polymorphisms in the south of Europe.
Drug-Related Side Effects and Adverse Reactions
Psychotropic medications and cytochrome P450 2D6: pharmacokinetic considerations in the elderly.
Drug-Related Side Effects and Adverse Reactions
Quantum mechanics/molecular mechanics modeling of regioselectivity of drug metabolism in cytochrome P450 2C9.
Drug-Related Side Effects and Adverse Reactions
Re: no evidence of increased adverse drug reactions in cytochrome P450 CYP2D6 poor metabolizers treated with fluoxetine or nortriptyline.
Drug-Related Side Effects and Adverse Reactions
Risperidone-associated adverse drug reactions and CYP2D6 polymorphisms in a South African cohort.
Drug-Related Side Effects and Adverse Reactions
Role of cytochrome P450 polymorphisms in the development of pulmonary drug toxicity: a case-control study in the Netherlands.
Drug-Related Side Effects and Adverse Reactions
Screening for genotypic and phenotypic variations in CYP450 activity in patients with therapeutic problems in a psychiatric setting, a retrospective study.
Drug-Related Side Effects and Adverse Reactions
Serotonin syndrome induced by low-dose venlafaxine.
Drug-Related Side Effects and Adverse Reactions
Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice.
Drug-Related Side Effects and Adverse Reactions
Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity.
Drug-Related Side Effects and Adverse Reactions
Significant inhibitory impact of dibenzyl trisulfide and extracts of Petiveria alliacea on the activities of major drug-metabolizing enzymes in vitro: An assessment of the potential for medicinal plant-drug interactions.
Drug-Related Side Effects and Adverse Reactions
Simultaneous measurement of 23 isoforms from the human cytochrome P450 families 1 to 3 by quantitative reverse transcriptase-polymerase chain reaction.
Drug-Related Side Effects and Adverse Reactions
Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9.
Drug-Related Side Effects and Adverse Reactions
The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation.
Drug-Related Side Effects and Adverse Reactions
The development of drug metabolising enzymes and their influence on the susceptibility to adverse drug reactions in children.
Drug-Related Side Effects and Adverse Reactions
The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects.
Drug-Related Side Effects and Adverse Reactions
The enhancement of cardiotoxicity that results from inhibiton of CYP 3A4 activity and hERG channel by berberine in combination with statins.
Drug-Related Side Effects and Adverse Reactions
The Human Cytochrome P450 Allele Nomenclature Committee Web Site : Submission Criteria, Procedures, and Objectives.
Drug-Related Side Effects and Adverse Reactions
The human cytochrome P450 Allele Nomenclature Committee Web site: submission criteria, procedures, and objectives.
Drug-Related Side Effects and Adverse Reactions
The impact of drug interactions on adverse effects of oral oxycodone in male geriatric patients.
Drug-Related Side Effects and Adverse Reactions
The Importance of CYP2E1 in the Pathogenesis of Alcoholic Liver Disease and Drug Toxicity and the Role of the Proteasome.
Drug-Related Side Effects and Adverse Reactions
The influence of CYP3A5 polymorphisms on haloperidol treatment in patients with alcohol addiction.
Drug-Related Side Effects and Adverse Reactions
The predictive value of ABCB1, ABCG2, CYP3A4/5 and CYP2D6 polymorphisms for risperidone and aripiprazole plasma concentrations and the occurrence of adverse drug reactions.
Drug-Related Side Effects and Adverse Reactions
The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity.
Drug-Related Side Effects and Adverse Reactions
The role of genetic polymorphisms in cytochrome P450 and effects of tuberculosis co-treatment on the predictive value of CYP2B6 SNPs and on efavirenz plasma levels in adult HIV patients.
Drug-Related Side Effects and Adverse Reactions
The role of sex, age and genetic polymorphisms of CYP enzymes on the pharmacokinetics of anticholinergic drugs.
Drug-Related Side Effects and Adverse Reactions
The Roles of Long Noncoding RNAs HNF1?-AS1 and HNF4?-AS1 in Drug Metabolism and Human Diseases.
Drug-Related Side Effects and Adverse Reactions
Transfer learning enables prediction of CYP2D6 haplotype function.
Drug-Related Side Effects and Adverse Reactions
Trimipramine pharmacokinetics after intravenous and oral administration in carriers of CYP2D6 genotypes predicting poor, extensive and ultrahigh activity.
Drug-Related Side Effects and Adverse Reactions
Update on Allele Nomenclature for Human Cytochromes P450 and the Human Cytochrome P450 Allele (CYP-Allele) Nomenclature Database.
Drug-Related Side Effects and Adverse Reactions
Utilization of pharmacogenomics and therapeutic drug monitoring for opioid pain management.
Drug-Related Side Effects and Adverse Reactions
Variation in the CYP2D6 genotype is not associated with carvedilol dose changes in patients with heart failure.
Drug-Related Side Effects and Adverse Reactions
Warfarin Dosing in a Patient with CYP2C9(?)3(?)3 and VKORC1-1639 AA Genotypes.
Drug-Related Side Effects and Adverse Reactions
Whole-cell biotransformation assay for investigation of the human drug metabolizing enzyme CYP3A7.
Drug-Related Side Effects and Adverse Reactions
[Effects of Reduning injection on activity of hepatic microsomal CYP450 isozymes in rats].
Drug-Related Side Effects and Adverse Reactions
[Genetic polymorphism of drug metabolizing enzymes: new mutations in CYP2D6 and CYP2A6 genes in Japanese]
Drug-Related Side Effects and Adverse Reactions
[Genetic polymorphisms in drug-metabolizing enzymes]
Ductus Arteriosus, Patent
Cimetidine-associated patent ductus arteriosus is mediated via a cytochrome P450 mechanism independent of H2 receptor antagonism.
Ductus Arteriosus, Patent
Polymorphisms in CYP2C9 are associated with response to indomethacin among neonates with patent ductus arteriosus.
Duodenal Ulcer
Polymorphisms and the pocketbook: the cost-effectiveness of cytochrome P450 2C19 genotyping in the eradication of Helicobacter pylori infection associated with duodenal ulcer.
Duodenogastric Reflux
Cytochrome P450 1B1 expression in rat esophageal tumorigenesis promoted by gastric and duodenal reflux.
Dwarfism
Arabidopsis thaliana RALF1 opposes brassinosteroid effects on root cell elongation and lateral root formation.
Dwarfism
The DWF4 gene of Arabidopsis encodes a cytochrome P450 that mediates multiple 22alpha-hydroxylation steps in brassinosteroid biosynthesis.
Dyskinesias
A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia.
Dyskinesias
Abnormal movements and tardive dyskinesia in smokers and nonsmokers with schizophrenia genotyped for cytochrome P450 2D6.
Dyskinesias
Association between cytochrome P4502D6 (CYP2D6) genotype, antipsychotic exposure, and abnormal involuntary movement scale (AIMS) score.
Dyskinesias
Long-term safety and efficacy of deutetrabenazine for the treatment of tardive dyskinesia.
Dyskinesias
Methylphenidate-Induced Chorea Due to Possible Cytochrome P450 Metabolism Heterogeneity - A Rare Case.
Dyskinesias
The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation.
Dyslipidemias
Cyclocarya paliurus Leaves Tea Improves Dyslipidemia in Diabetic Mice: A Lipidomics-Based Network Pharmacology Study.
Dyslipidemias
Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis.
Dyslipidemias
Effect of pigeon pea (Cajanus cajan L.) on high-fat diet-induced hypercholesterolemia in hamsters.
Dyslipidemias
Low myopathy rates associated with statins as monotherapy or combination therapy with interacting drugs in a group model health maintenance organization.
Dyslipidemias
Non-alcoholic Steatohepatitis (NASH) Drug Discovery - Building a Consensus on ADME Screening Tools and Clinical Pharmacology Strategies to Aid Candidate Development.
Dyslipidemias
Ovariectomy-Induced Hepatic Lipid and Cytochrome P450 Dysmetabolism Precedes Serum Dyslipidemia.
Dyslipidemias
Rhabdomyolysis in an HIV-Infected Patient on Anti-Retroviral Therapy Precipitated by High-Dose Pravastatin.
Dystonia
Acute pharmacogenetic dystonic reactions in a family with the CYP2D6 *41 allele: a case report.
Dystonia
Metoclopramide-Induced Acute Dystonic Reactions May Be Associated With the CYP2D6 Poor Metabolizer Status and Pregnancy-Related Hormonal Changes.
Dystonia
[Acute dyskinetic syndrome during chloropromazine treatment of a female patient with CYP2D6 poor metabolism phenotype]
Echinococcosis
[Associations of the genotypes of the CYP1A1 gene with predisposition to hydatid disease caused by Echinococcus granulosus strain G1]
Ectropion
Molecular Characterization Of Newborn Glaucoma Including A Distinct Aniridic Phenotype.
Embolic Stroke
Effect of race/ethnicity on the efficacy of warfarin : potential implications for prevention of stroke in patients with atrial fibrillation.
Embolic Stroke
Warfarin loading dose guided by pharmacogenetics is effective and safe in cardioembolic stroke patients - a randomized, prospective study.
Embolism
Adverse Interaction between Capecitabine and Warfarin Resulting in Altered Coagulation Parameters: A Review of the Literature Starting from a Case Report.
Embolism
Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation.
Embolism and Thrombosis
Adverse Interaction between Capecitabine and Warfarin Resulting in Altered Coagulation Parameters: A Review of the Literature Starting from a Case Report.
Empyema
CYP1A1, GCLC, AGT, AGTR1 gene-gene interactions in community-acquired pneumonia pulmonary complications.
Encephalitis
Identification of cytochrome P450 isoforms involved in the metabolism of Syl930, a selective S1PR1 agonist acting as a potential therapeutic agent for autoimmune encephalitis.
End Stage Liver Disease
Effects of plasma from patients with acute on chronic liver failure on function of cytochrome P450 in immortalized human hepatocytes.
Endocrine System Diseases
The single-nucleotide polymorphism rs743572 of CYP17A1 shows significant association with polycystic ovary syndrome: a meta-analysis.
Endometrial Hyperplasia
Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies.
Endometrial Hyperplasia
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Endometrial Hyperplasia
CYP1A1 gene polymorphism and risk of endometrial hyperplasia and endometrial carcinoma.
Endometrial Hyperplasia
Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation.
Endometrial Hyperplasia
Functional investigation on aromatase in endometrial hyperplasia in polycystic ovary syndrome cases.
Endometrial Hyperplasia
In situ estrogen metabolism in proliferative endometria from untreated women with polycystic ovarian syndrome with and without endometrial hyperplasia.
Endometrial Hyperplasia
[Aromatase (P450AROM) mRNA expression in normal, hyperplastic and malignant endometrium and aromatase activity in endometrial cancer tissue culture]
Endometrial Neoplasms
7,12-Dimethylbenzanthracene induces apoptosis in RL95-2 human endometrial cancer cells: ligand-selective activation of cytochrome P450 1B1.
Endometrial Neoplasms
A remark about CYP1A1 Thr461Asn genotype frequencies in a recent endometrial cancer case-control study.
Endometrial Neoplasms
Altered expression of lysophosphatidic acid receptors, in association with the synthesis of estrogens and androgens in type 1 endometrial cancer biology.
Endometrial Neoplasms
Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies.
Endometrial Neoplasms
Association between cytochrome P450 1A1 MspI polymorphism and endometrial cancer risk: a meta-analysis.
Endometrial Neoplasms
Association of CYP1B1 gene polymorphisms and the positive expression of estrogen alpha and estrogen beta with endometrial cancer risk.
Endometrial Neoplasms
Association of CYP1B1 gene polymorphisms with susceptibility to endometrial cancer: a meta-analysis.
Endometrial Neoplasms
Benzo[a]pyrene induces apoptosis in RL95-2 human endometrial cancer cells by cytochrome P450 1A1 activation.
Endometrial Neoplasms
Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes.
Endometrial Neoplasms
CYP17 and CYP19 genetic polymorphisms in endometrial cancer: association with intratumoral aromatase activity.
Endometrial Neoplasms
CYP19 gene expression and aromatase activity in endometrial cancer tissue: importance of the type of the disease.
Endometrial Neoplasms
CYP1A1 gene polymorphism and risk of endometrial hyperplasia and endometrial carcinoma.
Endometrial Neoplasms
CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility.
Endometrial Neoplasms
CYP1B1 gene polymorphisms have higher risk for endometrial cancer, and positive correlations with estrogen receptor alpha and estrogen receptor beta expressions.
Endometrial Neoplasms
Cytochrome P450 1A1 gene polymorphisms and endometrial cancer risk: a meta-analysis.
Endometrial Neoplasms
Cytochrome P450 1A1, cigarette smoking, and risk of endometrial cancer (United States).
Endometrial Neoplasms
Cytochrome P450 1B1 and catechol-O-methyltransferase genetic polymorphisms and endometrial cancer risk in Chinese women.
Endometrial Neoplasms
Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms and endometrial cancer susceptibility.
Endometrial Neoplasms
Cytochrome P450 1B1 gene polymorphisms and postmenopausal endometrial cancer risk.
Endometrial Neoplasms
Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity.
Endometrial Neoplasms
Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: Lower levels of CYP1B1 and increased expression of S-COMT.
Endometrial Neoplasms
Expression of enzyme associated with steroid hormone synthesis and local production of steroid hormone in endometrial carcinoma cells.
Endometrial Neoplasms
Expression profile of CYP1A1 and CYP1B1 enzymes in endometrial tumors.
Endometrial Neoplasms
Functional significance of cytochrome P450 1B1 in endometrial carcinogenesis.
Endometrial Neoplasms
Genetic factors in catechol estrogen metabolism in relation to the risk of endometrial cancer.
Endometrial Neoplasms
Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility.
Endometrial Neoplasms
Hormonal imbalance in two types of endometrial cancer and genetic polymorphism of steroidogenic enzymes.
Endometrial Neoplasms
Importance of CYP1A1 polymorphism and its transcriptional regulation in ovarian and endometrial cancer.
Endometrial Neoplasms
Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial cancer risk: a meta-analysis.
Endometrial Neoplasms
Letter regarding Li et al. entitled "Quantitative assessment of the association between CYP1A1 A4889G polymorphism and endometrial cancer risk"
Endometrial Neoplasms
No Association Between the CYP1B1 C4326G Polymorphism and Endometrial Cancer Risk: a Meta-analysis.
Endometrial Neoplasms
Polymorphism of the ERalpha and CYP1B1 genes in endometrial cancer in a Polish subpopulation.
Endometrial Neoplasms
Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk.
Endometrial Neoplasms
Preventive Efficacy of Vanillic Acid on Regulation of Redox Homeostasis, Matrix Metalloproteinases and Cyclin D1 in Rats Bearing Endometrial Carcinoma.
Endometrial Neoplasms
Progesterone potentiates the growth inhibitory effects of calcitriol in endometrial cancer via suppression of CYP24A1.
Endometrial Neoplasms
Prostaglandin E2 triggers cytochrome P450 17? hydroxylase overexpression via signal transducer and activator of transcription 3 phosphorylation and promotes invasion in endometrial cancer.
Endometrial Neoplasms
Quantitative assessment of the association between CYP1A1 A4889G polymorphism and endometrial cancer risk.
Endometrial Neoplasms
Retraction: CYP1B1 Gene Polymorphisms Have Higher Risk for Endometrial Cancer, and Positive Correlations with Estrogen Receptor ? and Estrogen Receptor ? Expressions.
Endometrial Neoplasms
Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma.
Endometrial Neoplasms
Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer.
Endometrial Neoplasms
Short heterodimer partner (SHP) orphan nuclear receptor inhibits the transcriptional activity of aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT).
Endometrial Neoplasms
Susceptibility to endometrial cancer: influence of allelism at p53, glutathione S-transferase (GSTM1 and GSTT1) and cytochrome P-450 (CYP1A1) loci.
Endometrial Neoplasms
The aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) heterodimer interacts with naturally occurring estrogen response elements.
Endometrial Neoplasms
The influence of single nucleotide polymorphisms on the association between dietary acrylamide intake and endometrial cancer risk.
Endometrial Neoplasms
The polymorphisms of the CYP17 and CYP19 genes in endometrial cancer patients.
Endometrial Neoplasms
The postmenopausal ovary as an androgen-producing gland; hypothesis on the etiology of endometrial cancer.
Endometrial Neoplasms
The T/C polymorphism of the CYP17 gene and G/A polymorphism of the CYP19 gene in endometrial cancer.
Endometrial Neoplasms
[A polymorphism study of the CYP19 gene in endometrial cancer patients]
Endometrial Neoplasms
[Aromatase (P450AROM) mRNA expression in normal, hyperplastic and malignant endometrium and aromatase activity in endometrial cancer tissue culture]
Endometrial Neoplasms
[Genetic polymorphism of steroidogenic enzymes and steroid receptor level in tumors of the reproductive system]
Endometrial Neoplasms
[Preliminary study of gene expression profiling in human type I and II endometrial carcinoma]
Endometrial Neoplasms
[The risk of endometrial cancer appearance and CYP19 and COMT gene polymorphism]
Endometriosis
An Analysis of ESR2 and CYP19A1 Gene Expression Levels in Women With Endometriosis.
Endometriosis
Aromatase Inhibitors for Endometriosis-Associated Infertility; Do We Have Sufficient Evidence?
Endometriosis
Aromatase P450 messenger RNA expression in eutopic endometrium is not a specific marker for pelvic endometriosis.
Endometriosis
Association between endometriosis and genetic polymorphisms of the estradiol-synthesizing enzyme genes HSD17B1 and CYP19.
Endometriosis
Association between single nucleotide polymorphism of the CYP19A1 and ESR2 genes and endometriosis.
Endometriosis
Association of CYP1A1 (cytochrome P450) MspI polymorphism in women with endometriosis.
Endometriosis
Association of endometriosis risk and genetic polymorphisms involving biosynthesis of sex steroids and their receptors: an updating meta-analysis.
Endometriosis
Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japanese women.
Endometriosis
Association study between CYP17 gene polymorphism and endometriosis risk: A meta-analysis.
Endometriosis
Common variants in the CYP2C19 gene are associated with susceptibility to endometriosis.
Endometriosis
COMT 158G/A and CYP1B1 432C/G polymorphisms increase the risk of endometriosis and adenomyosis: a meta-analysis.
Endometriosis
CYP17, CYP1A1 and COMT polymorphisms and the risk of adenomyosis and endometriosis in Taiwanese women.
Endometriosis
CYP17A1 rs743572 polymorphism might contribute to endometriosis susceptibility: evidences from a case-control study.
Endometriosis
CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women.
Endometriosis
Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity.
Endometriosis
Detection of endometriosis using immunocytochemistry of P450 Aromatase expressions in eutopic endometrial cells obtained from menstrual sloughing: a diagnostic study.
Endometriosis
Differential expression of upstream stimulatory factor (USF) 2 variants in eutopic endometria from women with endometriosis: estradiol regulation.
Endometriosis
Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: A source of excessive hydroxy-estrogens and ROS?
Endometriosis
Effect of letrozole on estradiol production and P450 aromatase messenger RNA expression of cultured luteinized granulosa cells from women with and without endometriosis.
Endometriosis
Effect of Yikun Neiyi Wan on the expression of aromatase P450, COX-2, and ER related receptor in endometrial cells in vitro from patients with endometriosis.
Endometriosis
Elevated expression of CYP1A1 and gamma-SYNUCLEIN in human ectopic (ovarian) endometriosis compared with eutopic endometrium.
Endometriosis
Endometrial aromatase mRNA as a possible screening tool for advanced endometriosis and adenomyosis.
Endometriosis
Endometriosis as a detrimental condition for granulosa cell steroidogenesis and development: From molecular alterations to clinical impact.
Endometriosis
Estrogen production in endometriosis and use of aromatase inhibitors to treat endometriosis.
Endometriosis
Expression of Ah receptor and dioxin-related genes in human uterine endometrium in women with or without endometriosis.
Endometriosis
Expression of AhR and ARNT mRNA in cultured human endometrial explants exposed to TCDD.
Endometriosis
Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis.
Endometriosis
Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium.
Endometriosis
Expression of dioxin-related transactivating factors and target genes in human eutopic endometrial and endometriotic tissues.
Endometriosis
FSH receptor, KL1/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis.
Endometriosis
Functional analyses of endometriosis-related polymorphisms in the estrogen synthesis and metabolism-related genes.
Endometriosis
Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue.
Endometriosis
Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in eutopic endometrium from women with endometriosis, adenomyosis, or leiomyomas.
Endometriosis
Gonadotropin-Releasing Hormone Agonist Reduces Aromatase Cytochrome P450 and Cyclooxygenase-2 in Ovarian Endometrioma and Eutopic Endometrium of Patients with Endometriosis.
Endometriosis
GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and their relationship with advanced stages of endometriosis in South Indian women.
Endometriosis
High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome.
Endometriosis
Human arylhydrocarbon receptor repressor (AHRR) gene: genomic structure and analysis of polymorphism in endometriosis.
Endometriosis
IGF-I stimulates ER? and aromatase expression via IGF1R/PI3K/AKT-mediated transcriptional activation in endometriosis.
Endometriosis
Immunohistochemical localization of aromatase and apoptosis-associated proteins in ovarian serous cystadenocarcinoma arising from ovarian endometriosis.
Endometriosis
Increased expression of IgE-dependent histamine-releasing factor in endometriotic implants.
Endometriosis
Interaction between cytochrome P450 gene polymorphisms and serum organochlorine TEQ levels in the risk of endometriosis.
Endometriosis
Is cytochrome P450 3A4 regulated by menstrual cycle hormones in control endometrium and endometriosis?
Endometriosis
Linkage and association studies of the relationship between endometriosis and genes encoding the detoxification enzymes GSTM1, GSTT1 and CYP1A1.
Endometriosis
Liver receptor homologue-1 and steroidogenic factor-1 expression in cultured granulosa cells from patients with endometriosis: A preliminary study.
Endometriosis
Low-penetrance genes are associated with increased susceptibility to endometriosis.
Endometriosis
Metformin Suppresses Prostaglandin E2-Induced Cytochrome P450 Aromatase Gene Expression and Activity via Stimulation of AMP-Activated Protein Kinase in Human Endometriotic Stromal Cells.
Endometriosis
Pharmacological treatment of endometriosis: experience with aromatase inhibitors.
Endometriosis
Polymorphic variants of CYP17 and CYP19A and risk of infertility in endometriosis.
Endometriosis
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Endometriosis
Polymorphisms and haplotypes of the gene encoding the estrogen-metabolizing CYP19 gene in Korean women: no association with advanced-stage endometriosis.
Endometriosis
Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium.
Endometriosis
Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells.
Endometriosis
Regulation of aromatase P450 expression in endometriotic and endometrial stromal cells by CCAAT/enhancer binding proteins (C/EBPs): decreased C/EBPbeta in endometriosis is associated with overexpression of aromatase.
Endometriosis
Relationship between MspI polymorphism of CYP1A1 gene and the risk of endometriosis in an Iranian population: A case-control study.
Endometriosis
Role of cytochrome P450 2C19 polymorphisms and body mass index in endometriosis: A case-control study.
Endometriosis
Serum dioxin-like compounds and aromatase (CYP19) expression in endometriotic tissues.
Endometriosis
Single nucleotide polymorphisms and haplotypes of the genes encoding the CYP1B1 in Korean women: no association with advanced endometriosis.
Endometriosis
Smad3/4 Binding to Promoter II of P450arom So As to Regulate Aromatase Expression in Endometriosis.
Endometriosis
Spatially heterogeneous expression of aromatase P450 through promoter II is closely correlated with the level of steroidogenic factor-1 transcript in endometrioma tissues.
Endometriosis
Stimulation of aromatase P450 promoter (II) activity in endometriosis and its inhibition in endometrium are regulated by competitive binding of steroidogenic factor-1 and chicken ovalbumin upstream promoter transcription factor to the same cis-acting element.
Endometriosis
Ten estrogen-related polymorphisms and endometriosis: a study of multiple gene-gene interactions.
Endometriosis
The association between CYP19 polymorphism and endometriosis risk: a system review and meta-analysis.
Endometriosis
The association of endometriosis risk and genetic polymorphisms involving dioxin detoxification enzymes: A systematic review.
Endometriosis
The cytochrome P4501A1 gene polymorphisms and endometriosis: a meta-analysis.
Endometriosis
Valproic acid-induced histone acetylation suppresses CYP19 gene expression and inhibits the growth and survival of endometrial stromal cells.
Endometriosis
[Association between gene mutation of cytochrome P450 1A1 in exon 7 A4889G locus and susceptibility to endometriosis]
Endometriosis
[Association of the CYP19 gene polymorphism with genetic susceptibility to endometriosis].
Endometriosis
[Association of the CYP1B1 gene polymorphism with susceptibility to endometriosis]
Endometriosis
[Comparison of steroid metabolism markers in endometrium of women with endometriosis, endometrial hyperplasia and without pathological changes of endometrium]
Endometriosis
[Diagnostic value of the detection of aromatase cytochrome P450 and CA125 for endometriosis]
Endometriosis
[Expressions of aromatase P450 and estrogen receptor in eutopic and ectopic endometrium in endometriosis and their correlation with endometriosis]
Endometriosis
[Molecular biological features of ectopic and eutopic endometrium in genital endometriosis].
Endometriosis
[P450Arom and estrogenic microenvironment of eutopic endometria in endometriosis]
Endometriosis
[Susceptibility to endometriosis in women of Han Nationality in Guangdong Province associated with Msp I polymorphisms of cytochrome P450 1A1 gene]
Endotoxemia
Apoptosis of enterocytes and nitration of junctional complex proteins promote alcohol-induced gut leakiness and liver injury.
Endotoxemia
Changes of midazolam pharmacokinetics in Wistar rats treated with lipopolysaccharide: relationship between total CYP and CYP3A2.
Endotoxemia
CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis.
Endotoxemia
Down-regulation of cytochrome P450 mRNAs and proteins in mice lacking a functional NOS2 gene.
Endotoxemia
Down-regulation of the expression of three major rat liver cytochrome P450S by endotoxin in vivo occurs independently of nitric oxide production.
Endotoxemia
Endotoxemia in rats is associated with induction of the P4504A subfamily and suppression of several other forms of cytochrome P450.
Endotoxemia
Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia.
Endotoxemia
Microsomal Ethanol-Oxidizing System: Success Over 50 Years and an Encouraging Future.
Endotoxemia
Obesity and Inflammation and Altered Clopidogrel Pharmacokinetics and Pharmacodynamics.
Enterocolitis
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Eosinophilia
Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes.
Eosinophilia
The toxicity potential of pharmaceuticals found in the Douro River estuary (Portugal): evaluation of impacts on fish liver, by histopathology, stereology, vitellogenin and CYP1A immunohistochemistry, after sub-acute exposures of the zebrafish model.
Eosinophilic Esophagitis
Active Eosinophilic Esophagitis Is Associated with Impaired Elimination of Budesonide by Cytochrome P450 3A Enzymes.
Epilepsies, Myoclonic
In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism.
Epilepsies, Myoclonic
Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group.
Epilepsies, Myoclonic
Stiripentol: new preparation. Severe myoclonic epilepsy of infancy: promising.
Epilepsy
A case of cerebrotendinous xanthomatosis presenting with epilepsy as an initial symptom with a novel V413D mutation in the CYP27A1 gene.
Epilepsy
An association between the rs1799853 and rs1057910 polymorphisms of CYP2C9, the rs4244285 polymorphism of CYP2C19 and the prevalence rates of drug-resistant epilepsy in children.
Epilepsy
Antioxidants, enzyme induction, and chronic pancreatitis: a reappraisal following studies in patients on anticonvulsants.
Epilepsy
Association of CYP2C9, CYP2A6, ACSM2A, and CPT1A gene polymorphisms with adverse effects of valproic acid in Chinese patients with epilepsy.
Epilepsy
Association of polymorphisms of CYP2C9, CYP2C19, and ABCB1, and activity of P-glycoprotein with response to anti-epileptic drugs.
Epilepsy
Associations between CYP3A4, CYP3A5 and SCN1A polymorphisms and carbamazepine metabolism in epilepsy: A meta-analysis.
Epilepsy
Citalopram and Cannabidiol: In Vitro and In Vivo Evidence of Pharmacokinetic Interactions Relevant to the Treatment of Anxiety Disorders in Young People.
Epilepsy
Clinical relevance of genetic polymorphism in CYP2C9 gene to pharmacodynamics and pharmacokinetics of phenytoin in epileptic patients: validatory pharmacogenomic approach to pharmacovigilance.
Epilepsy
Combination treatment of epilepsy with ketogenic diet and concurrent pharmacological inhibition of cytochrome P450 2E1.
Epilepsy
CYP2C9 (*2&*3) and CYP2C19 (*2&*3) polymorphisms among children with nonlesional epilepsy: a single-center study.
Epilepsy
CYP2C9 polymorphism in patients with epilepsy: genotypic frequency analyzes and phenytoin adverse reactions correlation.
Epilepsy
CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy.
Epilepsy
CYP3A5?3 and C3435T MDR1 Polymorphisms in Prognostication of Drug-Resistant Epilepsy in Children and Adolescents.
Epilepsy
Dosage recommendation of phenytoin for patients with epilepsy with different CYP2C9/CYP2C19 polymorphisms.
Epilepsy
Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy.
Epilepsy
Effects of EPHX1, SCN1A and CYP3A4 genetic polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy.
Epilepsy
Effects of polymorphisms in six candidate genes on phenytoin maintenance therapy in Han Chinese patients.
Epilepsy
Effects of UGT1A6, UGT2B7, and CYP2C9 genotypes on plasma concentrations of valproic acid in Chinese children with epilepsy.
Epilepsy
Genetic contribution of CYP1A1 variant on treatment outcome in epilepsy patients: a functional and interethnic perspective.
Epilepsy
Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy.
Epilepsy
Genetic polymorphisms in sex hormone metabolizing genes and drug response in women with epilepsy.
Epilepsy
Genetic polymorphisms of CYP3A5, CHRM2, and ZNF498 and their association with epilepsy susceptibility: a pharmacogenetic and case-control study.
Epilepsy
Gephyrin and CYP2C9 Genetic Polymorphisms in Patients with Pharmacoresistant Epilepsy.
Epilepsy
Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures.
Epilepsy
Impact of CYP2C19 and CYP2C9 gene polymorphisms on sodium valproate plasma concentration in patients with epilepsy.
Epilepsy
Individualized phenytoin therapy for Japanese pediatric patients with epilepsy based on CYP2C9 and CYP2C19 genotypes.
Epilepsy
Influence of age and co-medication on the steady-state pharmacokinetics of valproic acid in Tunisian patients with epilepsy.
Epilepsy
Influence of genetic variants of CYP2D6, CYP2C9, CYP2C19 and CYP3A4 on antiepileptic drug metabolism in pediatric patients with refractory epilepsy.
Epilepsy
Inhibitory effect of valproic acid on cytochrome P450 2C9 activity in epilepsy patients.
Epilepsy
Liver enzyme induction and serum lipid levels after replacement of carbamazepine with oxcarbazepine.
Epilepsy
Modulation of androgen and estrogen receptor expression by antiepileptic drugs and steroids in hippocampus of patients with temporal lobe epilepsy.
Epilepsy
Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms.
Epilepsy
Neurovascular Drug Biotransformation Machinery in Focal Human Epilepsies: Brain CYP3A4 Correlates with Seizure Frequency and Antiepileptic Drug Therapy.
Epilepsy
Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.
Epilepsy
Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells.
Epilepsy
Pattern of P450 expression at the human blood-brain barrier: Roles of epileptic condition and laminar flow.
Epilepsy
Pharmacogenetic evaluation of ABCB1, Cyp2C9, Cyp2C19 and methylene tetrahydrofolate reductase polymorphisms in teratogenicity of anti-epileptic drugs in women with epilepsy.
Epilepsy
Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach.
Epilepsy
Phenoconversion of CYP2C9 in epilepsy limits the predictive value of CYP2C9 genotype in optimizing valproate therapy.
Epilepsy
Possible role of CYP2C9 & CYP2C19 single nucleotide polymorphisms in drug refractory epilepsy.
Epilepsy
Profound reduction in the tamoxifen active metabolite endoxifen in a patient on phenytoin for epilepsy compared with a CYP2D6 genotype matched cohort.
Epilepsy
Reproductive dysfunction in women with epilepsy: antiepileptic drug effects on sex-steroid hormones.
Epilepsy
Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels.
Epilepsy
The association of adjusted plasma valproic acid concentration with CYP2C9 gene polymorphism in patients with epilepsy: a systematic review and meta-analysis.
Epilepsy
The Effect of Genetic Polymorphisms of Cytochrome P450 CYP2C9, CYP2C19, and CYP2D6 on Drug-Resistant Epilepsy in Turkish Children.
Epilepsy
The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics.
Epilepsy
The influence of cytochrome oxidase CYP2A6, CYP2B6, and CYP2C9 polymorphisms on the plasma concentrations of valproic acid in epileptic patients.
Epilepsy
The influence of folate serum levels on depressive mood and mental processing in patients with epilepsy treated with enzyme-inducing anti-epileptic drugs.
Epilepsy
[Association between genetic polymorphisms of CYP2C19 and CYP2C9 and phenytoin serum concentration]
Epilepsy
[Development of rapid genotyping methods for single nucleotide polymorphisms of cytochrome P450 2C9 (CYP2C9) and cytochrome P450 2C19 (CYP2C19) and their clinical application in pediatric patients with epilepsy].
Epilepsy, Temporal Lobe
Modulation of androgen and estrogen receptor expression by antiepileptic drugs and steroids in hippocampus of patients with temporal lobe epilepsy.
Epistaxis
Topical timolol for treatment of epistaxis in hereditary haemorrhagic telangiectasia associated with bradycardia: a look at CYP2D6 metabolising variants.
Erectile Dysfunction
Effects of Lemon and Seville Orange Juices on the Pharmacokinetic Properties of Sildenafil in Healthy Subjects.
Erectile Dysfunction
Erectile dysfunction drugs altered the activities of antioxidant enzymes, oxidative stress and the protein expressions of some cytochrome P450 isozymes involved in the steroidogenesis of steroid hormones.
Erectile Dysfunction
In men with erectile dysfunction, satisfaction with quality of erections correlates with erection hardness, treatment satisfaction, and emotional well-being.
Erectile Dysfunction
The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study.
Erectile Dysfunction
The effects of steady-state erythromycin and azithromycin on the pharmacokinetics of sildenafil in healthy volunteers.
Esophageal Neoplasms
Association between CYP1A1 polymorphisms and esophageal cancer: a meta-analysis.
Esophageal Neoplasms
Association of CYP1A1 MspI polymorphism in the esophageal cancer risk: a meta-analysis in the Chinese population.
Esophageal Neoplasms
Association studies of CYP1A1 and GSTM1 polymorphisms with esophageal cancer risk: evidence-based meta-analyses.
Esophageal Neoplasms
Association Studies of CYP1A1 Exon7 Polymorphism and -GSTM1 Interaction with Esophageal Cancer Risk: a Meta-Analysis in the Chinese Population.
Esophageal Neoplasms
Associations between CYP1A1 and CYP2E1 polymorphisms and susceptibility to esophageal cancer in Chaoshan and Taihang areas of China.
Esophageal Neoplasms
Correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer among the Kazakh ethnic group in Xinjiang.
Esophageal Neoplasms
Cumulative Evidence for Associations between Genetic Variants and Risk of Esophageal Cancer.
Esophageal Neoplasms
CYP1A1 genetic polymorphisms and risk for esophageal cancer: a case-control study in central China.
Esophageal Neoplasms
CYP1A1 Msp1 T/C polymorphism in esophageal cancer: no association and risk modulation.
Esophageal Neoplasms
CYP1A1, CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus.
Esophageal Neoplasms
CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: study of population from a high- incidence area in north China.
Esophageal Neoplasms
CYP2E1 Rsa I/Pst I polymorphism and esophageal cancer risk: a meta-analysis based on 1,088 cases and 2,238 controls.
Esophageal Neoplasms
Cytochrome P450 1A1 (CYP1A1) polymorphism and susceptibility to esophageal cancer: an updated meta-analysis of 27 studies.
Esophageal Neoplasms
Cytochrome P450 1B1, a novel chemopreventive target for benzo[a]pyrene-initiated human esophageal cancer.
Esophageal Neoplasms
Cytochrome P450 2E1 RsaI/PstI polymorphism and risk of esophageal cancer: A meta-analysis of 17 case-control studies.
Esophageal Neoplasms
Cytochromes P4502E1 and P4501A1 genotypes and susceptibility to cirrhosis or upper aerodigestive tract cancer in alcoholic caucasians.
Esophageal Neoplasms
Depentylation of [3H-pentyl]methyl-n-amylnitrosamine by rat esophageal and liver microsomes and by rat and human cytochrome P450 isoforms.
Esophageal Neoplasms
Esophageal cancer proliferation is mediated by cytochrome P450 2C9 (CYP2C9).
Esophageal Neoplasms
Esophageal cancer risk by ALDH2 and ADH2 polymorphisms and alcohol consumption: exploration of gene-environment and gene-gene interactions.
Esophageal Neoplasms
Frequencies of poor metabolizers of cytochrome P450 2C19 in esophagus cancer, stomach cancer, lung cancer and bladder cancer in Chinese population.
Esophageal Neoplasms
Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population.
Esophageal Neoplasms
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility.
Esophageal Neoplasms
Genetic susceptibility to esophageal cancer due to CYP1A1 gene variant rs4646903 in tobacco addicted patients of Pashtun ethnicity: a case control study in Khyber Pakhtunkhwa province of Pakistan.
Esophageal Neoplasms
GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma.
Esophageal Neoplasms
Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China.
Esophageal Neoplasms
Meta-analysis of association studies of CYP1A1 genetic polymorphisms with digestive tract cancer susceptibility in Chinese.
Esophageal Neoplasms
Phase I/II enzyme gene polymorphisms and esophageal cancer risk: a meta-analysis of the literature.
Esophageal Neoplasms
Polymorphic expression of the glutathione S-transferase P1 gene and its susceptibility to Barrett's esophagus and esophageal carcinoma.
Esophageal Neoplasms
Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population.
Esophageal Neoplasms
Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in Xinjiang, China.
Esophageal Neoplasms
Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal cancer in Xi'an.
Esophageal Neoplasms
Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases T1, P1, and M1 and cytochrome P450 2E1.
Esophageal Neoplasms
Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer.
Esophageal Neoplasms
Transcriptional activity of the tandem repeat polymorphism in the 5'-flanking region of the human CYP2E1 gene.
Esophageal Neoplasms
[Genetic polymorphisms of cytochrome P450 2E1 and glutathione S-transferase P1 and susceptibility to esophageal cancer]
Esophageal Neoplasms
[Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma]
Esophageal Neoplasms
[Study on the association of cytochrome P450 polymorphisms and the risk of esophageal cancer: a meta-analysis.]
Esophageal Squamous Cell Carcinoma
Association of combined CYP2E1 gene polymorphism with the risk for esophageal squamous cell carcinoma in Huai'an population, China.
Esophageal Squamous Cell Carcinoma
Association of Genetic Variants of CYP2C19 and CYP2D6 with Esophageal Squamous Cell Carcinoma Risk in Northern India, Kashmir.
Esophageal Squamous Cell Carcinoma
Cumulative Evidence for Associations between Genetic Variants and Risk of Esophageal Cancer.
Esophageal Squamous Cell Carcinoma
CYP1A1 and CYP2E1 genotypes and risk of esophageal squamous cell carcinoma in a high-incidence region, Kashmir.
Esophageal Squamous Cell Carcinoma
CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: study of population from a high- incidence area in north China.
Esophageal Squamous Cell Carcinoma
CYP2C9 inhibits the invasion and migration of esophageal squamous cell carcinoma via downregulation of HDAC.
Esophageal Squamous Cell Carcinoma
Esophageal cancer proliferation is mediated by cytochrome P450 2C9 (CYP2C9).
Esophageal Squamous Cell Carcinoma
Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review).
Esophageal Squamous Cell Carcinoma
Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males.
Esophageal Squamous Cell Carcinoma
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility.
Esophageal Squamous Cell Carcinoma
GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma.
Esophageal Squamous Cell Carcinoma
Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation.
Esophageal Squamous Cell Carcinoma
Polymorphic variation of Cyp1A1 is associated with the risk of gastric cardia cancer: a prospective case-cohort study of cytochrome P-450 1A1 and GST enzymes.
Esophageal Squamous Cell Carcinoma
[Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma]
Esophagitis, Peptic
Cytochrome P450 2C19 polymorphism influences the preventive effect of lansoprazole on the recurrence of erosive reflux esophagitis.
Esophagitis, Peptic
Genetic polymorphisms of CYP2C19 and IL1B have no influence on esomeprazole treatment for mild erosive esophagitis.
Esophagitis, Peptic
Role of cytochrome P450 2C19 genetic polymorphisms in the therapeutic efficacy of omeprazole in Iranian patients with erosive reflux esophagitis.
Essential Hypertension
A Novel Polymorphism of the CYP19 Gene is Associated with Essential Hypertension in China.
Essential Hypertension
Association of CYP2D6 and ADRB1 genes with hypotensive and antichronotropic action of betaxolol in patients with arterial hypertension.
Essential Hypertension
Association of CYP3A5 Gene Polymorphisms and Amlodipine-Induced Peripheral Edema in Chinese Han Patients with Essential Hypertension.
Essential Hypertension
Association of Cytochrome P450 2C9*3 and Angiotensin II Receptor 1 (1166A>C) Gene Polymorphisms With the Antihypertensive Effect of Irbesartan.
Essential Hypertension
Associations between ADRB1 and CYP2D6 gene polymorphisms and the response to ?-blocker therapy in hypertension.
Essential Hypertension
CYP2E1 gene promoter polymorphism -1293G>C increases the risk of essential hypertension in men with alcohol abuse.
Essential Hypertension
Cytochrome P450 1A1 (CYP1A1) T6325C polymorphism might modulate essential hypertension-associated stroke risk.
Essential Hypertension
Effects of genetic factors on the pharmacokinetics and pharmacodynamics of amlodipine in primary hypertensive patients.
Essential Hypertension
Effects of polymorphism of the beta(1) adrenoreceptor and CYP2D6 on the therapeutic effects of metoprolol.
Essential Hypertension
Gender-Specific Effect of CYP2C8*3 on the Risk of Essential Hypertension in Bulgarian Patients.
Essential Hypertension
Sex-specific role of CYP24A1 rs2762939 in the risk of essential hypertension based on the serum vitamin D and total renin concentrations.
Essential Hypertension
The Association of ADRB1 and CYP2D6 Polymorphisms With Antihypertensive Effects and Analysis of Their Contribution to Hypertension Risk.
Essential Hypertension
The CYP2C9 genotype predicts the blood pressure response to irbesartan: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA) trial.
Essential Hypertension
The expression level of myocardial ?1-adrenergic receptor affects metoprolol antihypertensive effects: a novel mechanism for interindividual difference.
Essential Hypertension
The influence of CYP2D6 phenotype on the clinical response of nebivolol in patients with essential hypertension.
Essential Tremor
Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor.
Esthesioneuroblastoma, Olfactory
[Esthesioneuroblastoma: a case report and literature review]
Esthesioneuroblastoma, Olfactory
[Esthesioneuroblastoma: A single institution's experience and general literature review].
Exanthema
Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash.
Exanthema
Pharmacogenomics and COVID-19: clinical implications of human genome interactions with repurposed drugs.
Exanthema
Polymorphisms of Drug-Metabolizing Enzymes and Transporters Contribute to the Individual Variations of Erlotinib Steady State Trough Concentration, Treatment Outcomes, and Adverse Reactions in Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer Patients.
Exanthema
Reduced CYP2D6 function is associated with gefitinib-induced rash in patients with non-small cell lung cancer.
Exophthalmos
[EXOPHTHALMOS, EXCEPTIONAL REVELATORY SIGN OF A TUMOR OF THE OLFACTIVE PLACODE. ESTHESIONEUROEPITHELIOMA. HISTOLOGICAL RELATION OF THIS TUMOR TO NERVOUS RETINAL TUMORS.]
Exophthalmos
[Influence of CYP3A4, CYP3A5, and NR3C1 genes polymorphism on the effectiveness of glucocorticoid therapy in patients with endocrine ophthalmopathy].
Eye Diseases
Exome sequencing in developmental eye disease leads to identification of causal variants in GJA8, CRYGC, PAX6 and CYP1B1.
Eye Diseases
Neural crest derivatives in ocular development: discerning the eye of the storm.
Familial Primary Pulmonary Hypertension
Evaluation of drug-drug interaction potential of beraprost sodium mediated by P450 in vitro.
Fanconi Anemia
The FANCG Fanconi anemia protein interacts with CYP2E1: possible role in protection against oxidative DNA damage.
Fascioliasis
Induction of drug metabolizing enzymes in the liver of rats infested with Fasciola hepatica.
Fascioliasis
The effects of fascioliasis on the activities of some drug-metabolizing enzymes in desert sheep liver.
Fatty Liver
Alcohol steatosis and cytotoxicity: The role of cytochrome P4502E1 and autophagy.
Fatty Liver
Altered activity of cytochrome P450 in alcoholic fatty liver exposed to ischemia/reperfusion.
Fatty Liver
Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis.
Fatty Liver
Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice.
Fatty Liver
Chronic Ethanol Consumption and Generation of Etheno-DNA Adducts in Cancer-Prone Tissues.
Fatty Liver
Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis.
Fatty Liver
CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model.
Fatty Liver
Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis.
Fatty Liver
CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis.
Fatty Liver
Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1? in vivo.
Fatty Liver
Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications.
Fatty Liver
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Fatty Liver
Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver.
Fatty Liver
Defining a relationship between dietary fatty acids and the cytochrome P450 system in a mouse model of fatty liver disease.
Fatty Liver
Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet.
Fatty Liver
Diet-induced non-alcoholic fatty liver disease affects expression of major cytochrome P450 genes in a mouse model.
Fatty Liver
Dietary carbohydrate intake plays an important role in preventing alcoholic fatty liver in the rat.
Fatty Liver
Dietary restriction of energy and sugar results in a reduction in human cytochrome P450 2E1 activity.
Fatty Liver
Dietary trans 10, cis 12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver.
Fatty Liver
Does steatohepatitis impair liver regeneration? A study in a dietary model of non-alcoholic steatohepatitis in rats.
Fatty Liver
Effect of a stilbene glycoside-rich extract from Polygoni Multiflori Radix on experimental non-alcoholic fatty liver disease based on principal component and orthogonal partial least squares discriminant analysis.
Fatty Liver
Effects of binge ethanol on lipid homeostasis and oxidative stress in a rat model of nonalcoholic fatty liver disease.
Fatty Liver
Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis.
Fatty Liver
Extracellular matrix and cytochrome P450 gene expression can distinguish steatohepatitis from steatosis in mice.
Fatty Liver
Gene expression on liver toxicity induced by administration of haloperidol in rats with severe fatty liver.
Fatty Liver
Genetic Association and Gene-Gene Interaction Reveal Genetic Variations in ADH1B, GSTM1 and MnSOD Independently Confer Risk to Alcoholic Liver Diseases in India.
Fatty Liver
Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.
Fatty Liver
Genetic polymorphisms of the hepatic pathways of fatty liver disease after living donor liver transplantation.
Fatty Liver
Genetic variations of superoxide dismutase 2 and cytochrome P450 2E1 in non-alcoholic steatohepatitis.
Fatty Liver
Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis.
Fatty Liver
Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.
Fatty Liver
Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis.
Fatty Liver
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.
Fatty Liver
Hepatoprotective Effect of Seed Coat ofEuryale ferox Extract in Non-alcoholic Fatty Liver Disease Induced by High-fat Diet in Mice by Increasing IRs-1 and Inhibiting CYP2E1.
Fatty Liver
Identification of Compounds in Coleus forskohlii Extract Involved in the Induction of Hepatic CYP and Fatty Liver in Mice.
Fatty Liver
Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver.
Fatty Liver
Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation.
Fatty Liver
Influence of inducers and inhibitors of cytochrome P450 on the hepatotoxicity of hydrazine in vivo.
Fatty Liver
Inhibition of cytochrome P4502E1 by chlormethiazole attenuated acute ethanol-induced fatty liver.
Fatty Liver
Kynurenine-Induced Aryl Hydrocarbon Receptor Signaling in Mice Causes Body Mass Gain, Liver Steatosis, and Hyperglycemia.
Fatty Liver
Lack of common mutation in the alfa-subunit of the mitochondrial trifunctional protein and the polymorphism of CYP2E1 in three Japanese women with acute fatty liver of pregnancy/HELLP syndrome.
Fatty Liver
Molecular basis for a functional role of cytochrome P450 2E1 in non-alcoholic steatohepatitis.
Fatty Liver
Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model.
Fatty Liver
Non-alcoholic steatohepatitis: impaired antipyrine metabolism and hypertriglyceridaemia may be clues to its pathogenesis.
Fatty Liver
Oxidative stress and regulation of anti-oxidant enzymes in cytochrome P4502E1 transgenic mouse model of non-alcoholic fatty liver.
Fatty Liver
Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis.
Fatty Liver
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients.
Fatty Liver
Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress.
Fatty Liver
Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts.
Fatty Liver
PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease.
Fatty Liver
Protective effects of saponins from the root of Platycodon grandiflorum against fatty liver in chronic ethanol feeding via the activation of AMP-dependent protein kinase.
Fatty Liver
Reduction in hepatic cytochrome P-450 is correlated to the degree of liver fat content in animal models of steatosis in the absence of inflammation.
Fatty Liver
Regulation of the cytochrome P450 epoxyeicosanoid pathway is associated with distinct histologic features in pediatric non-alcoholic fatty liver disease.
Fatty Liver
Relationship between genetic polymorphism of cytochrome P450IIE1 and fatty liver.
Fatty Liver
Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients.
Fatty Liver
Reversal of obesity and liver steatosis in mice via inhibition of aryl hydrocarbon receptor and altered gene expression of CYP1B1, PPAR?, SCD1, and osteopontin.
Fatty Liver
Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity.
Fatty Liver
Role of CYP2E1 in the pathogenesis of alcoholic liver disease: modifications by cAMP and ubiquitin-proteasome pathway.
Fatty Liver
Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1.
Fatty Liver
Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets.
Fatty Liver
Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, nonalcoholic steatohepatitis obese women.
Fatty Liver
Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis.
Fatty Liver
Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice.
Fatty Liver
The CYP2E1 knockout delivers another punch: first ASH, now NASH. Alcoholic steatohepatitis. Nonalcoholic steatohepatitis.
Fatty Liver
The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease.
Fatty Liver
The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts.
Fatty Liver
Total sesquiterpene glycosides from Loquat (Eriobotrya japonica) leaf alleviate high-fat diet induced non-alcoholic fatty liver disease through cytochrome P450 2E1 inhibition.
Fatty Liver
Transcriptional Repression of CYP3A4 by Increased miR-200a-3p and miR-150-5p Promotes Steatosis in vitro.
Fatty Liver
Validated liquid chromatography-tandem mass spectrometry method for determination of totally nine probe metabolites of cytochrome P450 enzymes and UDP-glucuronosyltransferases.
Fatty Liver
Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models.
Fatty Liver
[Experimental study on inhibitory effect of Chinese herbal compound on hepatocyte cytochrome P450 II E1 expression in rat model of nonalcoholic fatty liver]
Fatty Liver, Alcoholic
?-Imidazolyl-alkyl derivatives as new preclinical drug candidates for treating non-alcoholic steatohepatitis.
Fatty Liver, Alcoholic
A new approach to drug therapy in non-alcoholic steatohepatitis (NASH).
Fatty Liver, Alcoholic
Altered activity of cytochrome P450 in alcoholic fatty liver exposed to ischemia/reperfusion.
Fatty Liver, Alcoholic
Correction: Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis.
Fatty Liver, Alcoholic
CYP1A2 contributes to alcohol-induced abnormal lipid metabolism through the PTEN/AKT/SREBP-1c pathway.
Fatty Liver, Alcoholic
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice.
Fatty Liver, Alcoholic
Dietary carbohydrate intake plays an important role in preventing alcoholic fatty liver in the rat.
Fatty Liver, Alcoholic
Does steatohepatitis impair liver regeneration? A study in a dietary model of non-alcoholic steatohepatitis in rats.
Fatty Liver, Alcoholic
Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis.
Fatty Liver, Alcoholic
Ethanol and liver: recent advances in the mechanisms of ethanol-induced hepatosteatosis.
Fatty Liver, Alcoholic
Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis.
Fatty Liver, Alcoholic
Pioglitazone, quercetin and hydroxy citric acid effect on cytochrome P450 2E1 (CYP2E1) enzyme levels in experimentally induced non alcoholic steatohepatitis (NASH).
Fatty Liver, Alcoholic
Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium.
Fatty Liver, Alcoholic
The CYP2E1 knockout delivers another punch: first ASH, now NASH. Alcoholic steatohepatitis. Nonalcoholic steatohepatitis.
Fatty Liver, Alcoholic
The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.
Fatty Liver, Alcoholic
The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat.
Fatty Liver, Alcoholic
Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition.
Febrile Neutropenia
Pharmacogenomics variation in drug metabolizing enzymes and transporters in relation to docetaxel toxicity in Lebanese breast cancer patients: paving the way for OMICs in low and middle income countries.
Fetal Alcohol Spectrum Disorders
ADH2 and CYP2E1 genetic polymorphisms: risk factors for alcohol-related birth defects.
Fetal Alcohol Spectrum Disorders
Expression of CYP2E1 during embryogenesis and fetogenesis in human cephalic tissues: implications for the fetal alcohol syndrome.
Fetal Alcohol Spectrum Disorders
Loop-Mediated Isothermal Amplification and Polymerase Chain Reaction Methods for Specific and Rapid Detection of Rhodococcus fascians.
Fetal Growth Retardation
A case-control study of CYP1A1, GSTT1 and GSTM1 gene polymorphisms, pregnancy smoking and fetal growth restriction.
Fetal Growth Retardation
A polymorphism in the CYP17 gene and intrauterine fetal growth restriction.
Fetal Growth Retardation
Alterations of placental cytochrome P450 1A1 and P-glycoprotein in tobacco-induced intrauterine growth retardation in rats.
Fetal Growth Retardation
Association of maternal xenobiotic-metabolizing gene polymorphisms with risk of fetal growth restriction.
Fetal Growth Retardation
Binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to AH receptor in placentas from normal versus abnormal pregnancy outcomes.
Fetal Growth Retardation
Drinking water contaminants, gene polymorphisms, and fetal growth.
Fetal Growth Retardation
Growth retardation of fetal rats exposed to nicotine in utero: possible involvement of CYP1A1, CYP2E1, and P-glycoprotein.
Fetal Growth Retardation
Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression.
Fetal Growth Retardation
The Function of Cytochrome P450 1A1 Enzyme (CYP1A1) and Aryl Hydrocarbon Receptor (AhR) in the Placenta.
Fetal Growth Retardation
The impact of intrauterine growth restriction on cytochrome P450 enzyme expression and activity.
Fibroma
Activation of CncC pathway by ROS burst regulates cytochrome P450 CYP6AB12 responsible for ?-cyhalothrin tolerance in Spodoptera litura.
Fibroma
The expression of P450 genes mediating fenpropathrin resistance is regulated by CncC and Maf in Tetranychus cinnabarinus (Boisduval).
Fibroma
Transcription factors, CncC and Maf, regulate expression of CYP6BQ genes responsible for deltamethrin resistance in Tribolium castaneum.
Fibromyalgia
Development and validation of a chemical hydrolysis method for dextromethorphan and dextrophan determination in urine samples: application to the assessment of CYP2D6 activity in fibromyalgia patients.
Fibrosarcoma
Indigofera aspalathoides protection against 20-methylcholanthrene-induced experimental fibrosarcoma growth after transplantation in rats - role of xenobiotic drug metabolizing enzymes.
Fibrosarcoma
Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by bergamottin via the inhibition of protein kinase Cdelta/p38 mitogen-activated protein kinase and JNK/nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression.
Focal Nodular Hyperplasia
CYP1A1 alleles in women with focal nodular hyperplasia of the liver (FNH).
Focal Nodular Hyperplasia
Expression of xenobiotic and steroid hormone metabolizing enzymes in hepatocellular tumors of the non-cirrhotic liver.
Folic Acid Deficiency
Effects of folic acid supplementation on the pharmacokinetics and anticoagulant effect of warfarin: an open-label, prospective study of long-term administration in adults.
Follicular Cyst
Dominant bovine ovarian follicular cysts express increased levels of messenger RNAs for luteinizing hormone receptor and 3 beta-hydroxysteroid dehydrogenase delta(4),delta(5) isomerase compared to normal dominant follicles.
Foot Ulcer
Effects of Radix Astragali and Radix Rehmanniae, the components of an anti-diabetic foot ulcer herbal formula, on metabolism of model CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms.
Fractures, Spontaneous
Femoral Osteomyelitis Presenting as a Pathologic Fracture in a 53 Year Old Male: A Rare Case Report.
Frontotemporal Dementia
Debrisoquine hydroxylase gene polymorphism frequencies in patients with amyotrophic lateral sclerosis.
Gallbladder Neoplasms
Association between the CYP1A1 T3801C polymorphism and risk of cancer: evidence from 268 case-control studies.
Gallbladder Neoplasms
Association of CYP1A1 Msp1 polymorphism with tobacco-related risk of gallbladder cancer in a north Indian population.
Gallbladder Neoplasms
Carcinogen Metabolism Pathway and Tumor Suppressor Gene Polymorphisms and Gallbladder Cancer Risk in North Indians: A Hospital-Based Case-Control Study.
Gallbladder Neoplasms
CYP1A1, GSTM1, GSTT1 and TP53 Polymorphisms and Risk of Gallbladder Cancer in Bolivians.
Gallbladder Neoplasms
Effect of genetic predisposition on the risk of gallbladder cancer in Hungary.
Gallbladder Neoplasms
Genetic polymorphisms of cytochrome P450 1A1 and risk of gallbladder cancer.
Gallbladder Neoplasms
Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese.
Gallbladder Neoplasms
Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China.
Gallstones
Association of genetic variants of xenobiotic and estrogen metabolism pathway (CYP1A1 and CYP1B1) with gallbladder cancer susceptibility.
Gastritis
GSTT1, GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population.
Gastritis, Atrophic
Frequent CYP1A1 expression in gastric cancers and their related lesions.
Gastritis, Atrophic
Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a Chinese population.
Gastroesophageal Reflux
Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny.
Gastroesophageal Reflux
Influence of cytochrome P450 2C19 genetic polymorphism and dosage of rabeprazole on accuracy of proton-pump inhibitor testing in Chinese patients with gastroesophageal reflux disease.
Gastroesophageal Reflux
Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers.
Gastroesophageal Reflux
[CLINICAL AND ENDOSCOPIC CHARACTERISTICS OF THE GASTRODUODENAL MUCOSAL LESIONS IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION WITH DIFFERENT BODY MASS STATUS].
Gastroesophageal Reflux
[How to choose correct proton pump inhibitors to patients with GERD?]
Gastrointestinal Diseases
Effect of azole antifungals ketoconazole and fluconazole on the pharmacokinetics of dexloxiglumide.
Gastrointestinal Diseases
Why oral opioids may not be effective in a subset of chronic pain patients.
Gastrointestinal Neoplasms
Extrahepatic cytochrome P450 epoxygenases: pathophysiology and clinical significance in human gastrointestinal cancers.
Gastrointestinal Neoplasms
RsaI but not DraI polymorphism in CYP2E1 gene increases the risk of gastrointestinal cancer in Malaysians: a case-control study.
Gastrointestinal Stromal Tumors
Biliary excretion of imatinib mesylate and its metabolite CGP 74588 in humans.
Gastrointestinal Stromal Tumors
Disposition of imatinib and its metabolite CGP74588 in a patient with chronic myelogenous leukemia and short-bowel syndrome.
Gastrointestinal Stromal Tumors
Genetic polymorphisms in ABCG2 and CYP1A2 are associated with imatinib dose reduction in patients treated for gastrointestinal stromal tumors.
Gastrointestinal Stromal Tumors
Influence of CYP2C8 polymorphisms on imatinib steady-state trough level in chronic myeloid leukemia and gastrointestinal stromal tumor patients.
Gastrointestinal Stromal Tumors
Influence of Cytochrome P450, ABC and SLC Gene Polymorphisms on Imatinib Therapy Outcome of Patients with Gastrointestinal Stromal Tumours (GIST).
Gastrointestinal Stromal Tumors
Sunitinib: new drug. For some gastrointestinal stromal tumours.
Gaucher Disease
A pooled analysis of adverse events in 393 adults with Gaucher disease type 1 from four clinical trials of oral eliglustat: Evaluation of frequency, timing, and duration.
Gaucher Disease
Allelic and phenotypic characterization of CYP2D6 and its encoded P450 cytochrome enzyme in a serie of Spanish type 1 Gaucher disease patients.
Gaucher Disease
Clinical response to eliglustat in treatment-naïve patients with Gaucher disease type 1: Post-hoc comparison to imiglucerase-treated patients enrolled in the International Collaborative Gaucher Group Gaucher Registry.
Gaucher Disease
Comorbidities and pharmacotherapies in patients with Gaucher disease type 1: The potential for drug-drug interactions.
Gaucher Disease
Effects of paroxetine, ketoconazole, and rifampin on the metabolism of eliglustat, an oral substrate reduction therapy for Gaucher disease type 1.
Gaucher Disease
How a concentration-effect analysis of data from the eliglustat thorough electrocardiographic study was used to support dosing recommendations.
Gaucher Disease
Impact of hepatic and renal impairment on the pharmacokinetics and tolerability of eliglustat therapy for Gaucher disease type 1.
Gaucher Disease
Long-term adverse event profile from four completed trials of oral eliglustat in adults with Gaucher disease type 1.
Gaucher Disease
Management and monitoring recommendations for the use of eliglustat in adults with type 1 Gaucher disease in Europe.
Gaucher Disease
Metabolizing profile of the cytochrome pathway CYP2D6, CYP3A4 and the ABCB 1 transporter in Spanish patients affected by Gaucher disease.
Gaucher Disease
Outcomes after 18 Months of Eliglustat Therapy in Treatment-Naïve Adults with Gaucher Disease Type 1: The Phase 3 ENGAGE Trial.
Genetic Diseases, Inborn
25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D.
Genetic Diseases, Inborn
Cerebrotendinous Xanthomatosis ataxia responsive to CDCA and Riluzole.
Genetic Diseases, Inborn
CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functions.
Genetic Diseases, Inborn
Disposition of drugs in cystic fibrosis. V. In vivo CYP2C9 activity as probed by (S)-warfarin is not enhanced in cystic fibrosis.
Genetic Diseases, Inborn
High Prevalence of Kidney Cysts in Patients With CYP24A1 Deficiency.
Genetic Diseases, Inborn
In Search of New Therapeutics-Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond.
Genetic Diseases, Inborn
Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat.
Genetic Diseases, Inborn
Towards Accurate Genotype-Phenotype Correlations in the CYP2D6 Gene.
Genital Diseases, Female
Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk.
Gilbert Disease
Correction of venlafaxine- and duloxetine-induced transaminase elevations with desvenlafaxine in a patient with Gilbert's syndrome.
Gilbert Disease
Disposition of propafenone in a poor metabolizer of CYP2D6 with Gilbert's syndrome.
Gilbert Disease
Effect of cimetidine on the metabolism of cholephilic dyes in Gilbert's syndrome.
Gingival Hyperplasia
Association of galactose single-point test levels and phenytoin metabolic polymorphisms with gingival hyperplasia in patients receiving long-term phenytoin therapy.
Gingival Overgrowth
How genetic variation was analyzed in phenytoin-induced gingival enlargement using single-nucleotide polymorphism of candidate gene CYP2C9?
Glaucoma
A Case of 22q11.2 Deletion Syndrome with Peters Anomaly, Congenital Glaucoma, and Heterozygous Mutation in CYP1B1.
Glaucoma
A clinical and molecular genetic study of German patients with primary congenital glaucoma.
Glaucoma
A clinical and molecular genetics study of primary congenital glaucoma in South Korea.
Glaucoma
A novel frameshift founder mutation in the cytochrome P450 1B1 (CYP1B1) gene is associated with primary congenital glaucoma in Morocco.
Glaucoma
A novel methodology for enhanced and consistent heterologous expression of unmodified human cytochrome P450 1B1 (CYP1B1).
Glaucoma
A novel truncating mutation of cytochrome P4501B1 (CYP1B1) gene in primary infantile glaucoma.
Glaucoma
A polymorphism in the CYP1B1 promoter is functionally associated with primary congenital glaucoma.
Glaucoma
A spectrum of CYP1B1 mutations associated with primary congenital glaucoma in families of Pakistani descent.
Glaucoma
An integrative data mining approach to identifying adverse outcome pathway signatures.
Glaucoma
Analysis of CYP1B1 sequence alterations in patients with primary open-angle glaucoma of Saudi origin.
Glaucoma
Axenfeld-Rieger Syndrome Associated with Congenital Glaucoma and Cytochrome P4501B1 Gene Mutations.
Glaucoma
Biallelic CPAMD8 Variants Are a Frequent Cause of Childhood and Juvenile Open-Angle Glaucoma.
Glaucoma
Bioinformatics analysis of CYP1B1 mutation hotspots in Chinese primary congenital glaucoma patients.
Glaucoma
Candidate Gene Analysis Identifies Mutations in CYP1B1 and LTBP2 in Indian Families with Primary Congenital Glaucoma.
Glaucoma
Carrier frequency of CYP1B1 mutations in the United States (an American Ophthalmological Society thesis).
Glaucoma
Characterization of the biochemical and structural phenotypes of four CYP1B1 mutations observed in individuals with primary congenital glaucoma.
Glaucoma
Clinical application of NGS-based SNP haplotyping for the preimplantation genetic diagnosis of primary open angle glaucoma.
Glaucoma
Clinical variability of CYP1B1 gene variants in Pakistani primary congenital glaucoma families.
Glaucoma
Clinical Variability of Primary Congenital Glaucoma in a Spanish Family With Cyp1b1 Gene Mutations.
Glaucoma
Complex genetics of glaucoma: defects in CYP1B1, and not MYOC, cause pathogenesis in an early-onset POAG patient with double variants at both loci.
Glaucoma
Compound heterozygous mutations in CYP1B1 gene leads to severe primary congenital glaucoma phenotype.
Glaucoma
Contribution of CYP1B1 mutations and founder effect to primary congenital glaucoma in Mexico.
Glaucoma
Corneal enlargement without optic disk cupping in children with recessive CYP1B1 mutations.
Glaucoma
Correlations of genotype with phenotype in Indian patients with primary congenital glaucoma.
Glaucoma
CYP1B1 and MYOC mutations in 116 Chinese patients with primary congenital glaucoma.
Glaucoma
CYP1B1 and MYOC variants in neonatal-onset versus infantile-onset primary congenital glaucoma.
Glaucoma
CYP1B1 copy number variation is not a major contributor to primary congenital glaucoma.
Glaucoma
CYP1B1 Cytopathy: Uncommon Phenotype of a Homozygous CYP1B1 Deletion as Internal Corneal Ulcer of Von Hippel.
Glaucoma
CYP1B1 gene analysis and phenotypic correlation in Portuguese children with primary congenital glaucoma.
Glaucoma
CYP1B1 Gene Analysis in Primary Congenital Glaucoma Brazilian Patients: Novel Mutations and Association With Poor Prognosis.
Glaucoma
CYP1B1 gene analysis in primary congenital glaucoma in Indonesian and European patients.
Glaucoma
CYP1B1 Gene and Phenotypic Correlation in Patients From Northeastern Brazil With Primary Congenital Glaucoma.
Glaucoma
CYP1B1 gene mutations with incomplete penetrance in a Chinese pedigree with primary congenital glaucoma: a case report and review of literatures.
Glaucoma
CYP1B1 genotype influences the phenotype in primary congenital glaucoma and surgical treatment.
Glaucoma
Cyp1b1 Mediates Periostin Regulation of Trabecular Meshwork Development by Suppression of Oxidative Stress.
Glaucoma
CYP1B1 mutation profile of Iranian primary congenital glaucoma patients and associated haplotypes.
Glaucoma
CYP1B1 mutational screening in a Portuguese cohort of primary congenital glaucoma patients.
Glaucoma
CYP1B1 Mutations are a Major Contributor to Juvenile-Onset Open Angle Glaucoma in Saudi Arabia.
Glaucoma
CYP1B1 Mutations in Individuals With Primary Congenital Glaucoma and Residing in Denmark.
Glaucoma
CYP1B1 mutations in Spanish patients with primary congenital glaucoma: phenotypic and functional variability.
Glaucoma
Cyp1b1 Regulates Ocular Fissure Closure Through a Retinoic Acid-Independent Pathway.
Glaucoma
CYP1B1, MYOC, and LTBP2 mutations in primary congenital glaucoma patients in the United States.
Glaucoma
CYP1B1-Related Anterior Segment Developmental Anomalies Novel Mutations for Infantile Glaucoma and Von Hippel's Ulcer Revisited.
Glaucoma
Cytochrome oxidase 2D6 gene polymorphism in primary open-angle glaucoma with various effects to ophthalmic timolol.
Glaucoma
Cytochrome P450 1B1 gene mutations in Japanese patients with primary congenital glaucoma(1).
Glaucoma
Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[a]anthracene.
Glaucoma
Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines.
Glaucoma
Disease gene candidates revealed by expression profiling of retinal ganglion cell development.
Glaucoma
Disease-causing mutations in proteins: structural analysis of the CYP1B1 mutations causing primary congenital glaucoma in humans.
Glaucoma
Effect of two mutations of human CYP1B1, G61E and R469W, on stability and endogenous steroid substrate metabolism.
Glaucoma
Embryonic expression of the optineurin (glaucoma) gene in different stages of mouse development.
Glaucoma
Evaluation of the CYP1B1 gene as a candidate gene in beagles with primary open-angle glaucoma (POAG).
Glaucoma
Exome Sequencing in a Swiss Childhood Glaucoma Cohort Reveals CYP1B1 and FOXC1 Variants as Most Frequent Causes.
Glaucoma
Expanding the clinical spectrum of COL1A1 mutations in different forms of glaucoma.
Glaucoma
Expression of cytochrome P450 (CYP) enzymes in human non-pigmented ciliary epithelial cells; induction of CYP1B1 expression by TCDD.
Glaucoma
Founder mutations of CYP1B1 gene in patients with congenital glaucoma from the United States and Brazil.
Glaucoma
Functional and Structural Analyses of CYP1B1 Variants Linked to Congenital and Adult-Onset Glaucoma to Investigate the Molecular Basis of These Diseases.
Glaucoma
Functional characterization of eight rare missense CYP1B1 variants involved in congenital glaucoma and their association with null genotypes.
Glaucoma
Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis.
Glaucoma
Generation of a human iPSC line from a patient with congenital glaucoma caused by mutation in CYP1B1 gene.
Glaucoma
Genetic heterogeneity and minor CYP1B1 involvement in the molecular basis of primary congenital glaucoma in Gypsies.
Glaucoma
Genetic homogeneity for inherited congenital microcoria loci in an Asian Indian pedigree.
Glaucoma
Genotype and phenotype correlations in congenital glaucoma: CYP1B1 mutations, goniodysgenesis, and clinical characteristics.
Glaucoma
Genotype-phenotype correlation in Moroccan patients with primary congenital glaucoma.
Glaucoma
Genotype/phenotype correlation in primary congenital glaucoma patients from different ethnic groups of the Israeli population.
Glaucoma
Genotype/Phenotype Correlation in Primary Congenital Glaucoma Patients in the Lebanese Population: A Pilot Study.
Glaucoma
Glaucoma in iran and contributions of studies in iran to the understanding of the etiology of glaucoma.
Glaucoma
Glaucoma-associated CYP1B1 mutations share similar haplotype backgrounds in POAG and PACG phenotypes.
Glaucoma
Globally, CYP1B1 mutations in primary congenital glaucoma are strongly structured by geographic and haplotype backgrounds.
Glaucoma
Goniodysgenesis variability and activity of CYP1B1 genotypes in primary congenital glaucoma.
Glaucoma
Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma.
Glaucoma
Heterozygous loss of function variants in CYP1B1 predispose to primary open angle glaucoma.
Glaucoma
High diagnostic yield of clinically unidentifiable syndromic growth disorders by targeted exome sequencing.
Glaucoma
Homozygous p.G61E mutation in a consanguineous Pakistani family with co-existence of juvenile-onset open angle glaucoma and primary congenital glaucoma.
Glaucoma
Identification of a single ancestral CYP1B1 mutation in Slovak Gypsies (Roms) affected with primary congenital glaucoma.
Glaucoma
Identification of novel CYP1B1 gene mutations in patients with primary congenital and primary open-angle glaucoma.
Glaucoma
Identification of novel mutations causing familial primary congenital glaucoma in Indian pedigrees.
Glaucoma
Identification of R368H as a predominant CYP1B1 allele causing primary congenital glaucoma in Indian patients.
Glaucoma
Identities and frequencies of variants in CYP1B1 causing primary congenital glaucoma in Pakistan.
Glaucoma
In silico analysis of five missense mutations in CYP1B1 gene in Pakistani families affected with primary congenital glaucoma.
Glaucoma
Investigating Genetic Factors Contributing to Variable Expressivity of Class I 17p13.3 Microduplication.
Glaucoma
Investigation of CYP1B1 Gene Involvement in Primary Congenital Glaucoma in Iraqi Children.
Glaucoma
Investigation of CYP1B1 mutations in Chinese patients with primary congenital glaucoma.
Glaucoma
Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis.
Glaucoma
Leu432Val polymorphism in CYP1B1 as a susceptible factor towards predisposition to primary open-angle glaucoma.
Glaucoma
Modification of ocular defects in mouse developmental glaucoma models by tyrosinase.
Glaucoma
Molecular analysis of CYP1B1 in Omani patients with primary congenital glaucoma: a pilot study.
Glaucoma
Molecular analysis of the CYP1B1 gene: identification of novel truncating mutations in patients with primary congenital glaucoma.
Glaucoma
Molecular basis for involvement of CYP1B1 in MYOC upregulation and its potential implication in glaucoma pathogenesis.
Glaucoma
Molecular characterisation of congenital glaucoma in a consanguineous Canadian community: a step towards preventing glaucoma related blindness.
Glaucoma
Molecular characterization of Axenfeld-Rieger spectrum and other anterior segment dysgeneses in a sample of Mexican patients.
Glaucoma
Molecular Characterization Of Newborn Glaucoma Including A Distinct Aniridic Phenotype.
Glaucoma
Multiple CYP1B1 mutations and incomplete penetrance in an inbred population segregating primary congenital glaucoma suggest frequent de novo events and a dominant modifier locus.
Glaucoma
Mutation analysis of seven known glaucoma-associated genes in Chinese patients with glaucoma.
Glaucoma
Mutation spectrum of CYP1B1 and MYOC genes in Korean patients with primary congenital glaucoma.
Glaucoma
Mutation spectrum of the CYP1B1 gene for congenital glaucoma in the Japanese population.
Glaucoma
Mutation spectrum of the CYP1B1 gene in Indian primary congenital glaucoma patients.
Glaucoma
Mutational analysis of CYP1B1 gene in Iranian pedigrees with glaucoma reveals known and novel mutations.
Glaucoma
Mutational analysis of the CYP1B1 gene in Pakistani primary congenital glaucoma patients: Identification of four known and a novel causative variant at the 3' splice acceptor site of intron 2.
Glaucoma
Mutational spectrum of the CYP1B1 gene in Iranain primary congenital glaucoma family.
Glaucoma
Mutational spectrum of the CYP1B1 gene in Pakistani patients with primary congenital glaucoma: novel variants and genotype-phenotype correlations.
Glaucoma
Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme.
Glaucoma
Mutations in CYP1B1, the gene for cytochrome P4501B1, are the predominant cause of primary congenital glaucoma in Saudi Arabia.
Glaucoma
Novel compound heterozygous mutations in CYP1B1 identified in a Chinese family with developmental glaucoma.
Glaucoma
Novel CYP1B1 mutations and a possible prognostic use for surgical management of congenital glaucoma.
Glaucoma
Novel CYP1B1 mutations in consanguineous Pakistani families with primary congenital glaucoma.
Glaucoma
Novel cytochrome P450 1B1 (CYP1B1) mutations in patients with primary congenital glaucoma in France.
Glaucoma
Novel cytochrome P4501B1 (CYP1B1) gene mutations in Japanese patients with primary congenital glaucoma.
Glaucoma
Null cyp1b1 Activity in Zebrafish Leads to Variable Craniofacial Defects Associated with Altered Expression of Extracellular Matrix and Lipid Metabolism Genes.
Glaucoma
Occurrence of MYOC and CYP1B1 variants in juvenile open angle glaucoma Brazilian patients.
Glaucoma
Ocular cytochrome P450s and transporters: roles in disease and endobiotic and xenobiotic disposition.
Glaucoma
Overview of Cytochrome P450 1B1 gene mutations in patients with primary congenital glaucoma.
Glaucoma
P.Gly61Glu and P.Arg368His Mutations in CYP1B1 that Cause Congenital Glaucoma may be Relatively Frequent in Certain Regions of Gilan Province, Iran.
Glaucoma
Phenotype and Genotype Correlation in Iranian Primary Congenital Glaucoma Patients.
Glaucoma
Phylogenetic evaluation of the CYP1B1 gene in patients with primary congenital glaucoma.
Glaucoma
Prevalence of CYP1B1 mutations in Australian patients with primary congenital glaucoma.
Glaucoma
Primary congenital glaucoma and Rieger's anomaly: extended haplotypes reveal founder effects for eight distinct CYP1B1 mutations.
Glaucoma
Primary congenital glaucoma caused by the homozygous F261L CYP1B1 mutation and paternal isodisomy of chromosome 2.
Glaucoma
Primary congenital glaucoma due to paternal uniparental isodisomy of chromosome 2 and CYP1B1 deletion.
Glaucoma
Primary congenital glaucoma in Vietnam: analysis and identification of novel CYP1B1 variants.
Glaucoma
Primary congenital glaucoma: a novel single-nucleotide deletion and varying phenotypic expression for the 1,546-1,555dup mutation in the GLC3A (CYP1B1) gene in 2 families of different ethnic origin.
Glaucoma
Primary congenital glaucoma: three case reports on novel mutations and combinations of mutations in the GLC3A (CYP1B1) gene.
Glaucoma
Research progress on human genes involved in the pathogenesis of glaucoma (Review).
Glaucoma
Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients.
Glaucoma
Screening Glaucoma Genes in Adult Glaucoma suggests a multiallelic contribution of CYP1B1 to Open Angle Glaucoma Phenotypes.
Glaucoma
Screening of common CYP1B1 mutations in Iranian POAG patients using a microarray-based PrASE protocol.
Glaucoma
Screening of CYP1B1 and LTBP2 genes in Saudi families with primary congenital glaucoma: genotype-phenotype correlation.
Glaucoma
Screening of CYP1B1 and MYOC in Moroccan families with primary congenital glaucoma: three novel mutations in CYP1B1.
Glaucoma
Screening of CYP1B1 Arg368His as predominant mutation in North Indian primary open angle glaucoma and juvenile onset glaucoma patients.
Glaucoma
Screening of the LTBP2 gene in 214 Chinese sporadic CYP1B1-negative patients with primary congenital glaucoma.
Glaucoma
Sequence analysis of MYOC and CYP1B1 in a Chinese pedigree of juvenile glaucoma with goniodysgenesis.
Glaucoma
Sex Bias in Primary Congenital Glaucoma Patients with and without CYP1B1 Mutations.
Glaucoma
Single amino acid mutations, but not common polymorphisms, decrease the activity of CYP1B1 against (-)benzo[a]pyrene-7R-trans-7,8-dihydrodiol.
Glaucoma
Single nucleotide polymorphism of MYOC affected the severity of primary open angle glaucoma.
Glaucoma
Structural assessment of PITX2, FOXC1, CYP1B1, and GJA1 genes in patients with Axenfeld-Rieger syndrome with developmental glaucoma.
Glaucoma
Sturge-Weber Syndrome With Congenital Glaucoma and Cytochrome P450 (CYP1B1) Gene Mutations.
Glaucoma
Survey of familial glaucoma shows a high incidence of cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) mutations in non-consanguineous congenital forms in a Spanish population.
Glaucoma
Targeted deletion of Cyp1b1 in pericytes results in attenuation of retinal neovascularization and trabecular meshwork dysgenesis.
Glaucoma
Targeted Screening for Predominant CYP1B1 Mutations in Primary Congenital Glaucoma.
Glaucoma
The Identification and Stereochemistry Analysis of a Novel Mutation p.(D367Tfs*61) in the CYP1B1 Gene: A Case Report.
Glaucoma
The loss of microglia activities facilitates glaucoma progression in association with CYP1B1 gene mutation (p.Gly61Glu).
Glaucoma
The p.Gly61Glu Mutation in CYP1B1 Affects the Extracellular Matrix in Glaucoma Patients.
Glaucoma
The TIGR gene, pathogenic mechanisms, and other recent advances in glaucoma genetics.
Glaucoma
The transcription factor gene FOXC1 exhibits a limited role in primary congenital glaucoma.
Glaucoma
Two novel variants in CYP1B1 gene: a major contributor of autosomal recessive primary congenital glaucoma with allelic heterogeneity in Pakistani patients.
Glaucoma
Ultrastructural Abnormalities of the Trabecular Meshwork Extracellular Matrix in Cyp1b1-Deficient Mice.
Glaucoma
Unusual Association of Aniridia with Aicardi-Goutières Syndrome-Related Congenital Glaucoma in a Tertiary Care Center.
Glaucoma
Variable Expressivity and High Penetrance of CYP1B1 Mutations Associated with Primary Congenital Glaucoma.
Glaucoma
Whole exome sequencing identifies multiple diagnoses in congenital glaucoma with systemic anomalies.
Glaucoma
[Analysis of the CYP1B1 gene mutation in primary congenital glaucoma patients of Hubei Han nationality]
Glaucoma
[Coding sequence analysis of CYP1B1 exon III in the Polish population of patients with primary congenital and juvenile glaucoma]
Glaucoma
[Construction of CYP1B1 gene haplotypes predisposing to primary congenital glaucoma through allele-specific PCR/restriction fragment length polymorphism analysis].
Glaucoma
[From congenital glaucoma to chronic open angle glaucoma in adulthood: a clinical and genetic continuum].
Glaucoma
[Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg]
Glaucoma
[Homozygous E387K (1159G>A) mutation of the CYP1B1 gene in a Roma boy affected with primary congenital glaucoma. Case report].
Glaucoma
[Two variants in MYOC and CYP1B1 genes in a Chinese family with primary angle-closure glaucoma.]
Glaucoma, Angle-Closure
A polymorphism in the CYP1B1 promoter is functionally associated with primary congenital glaucoma.
Glaucoma, Angle-Closure
Association of eNOS polymorphisms with primary angle-closure glaucoma.
Glaucoma, Angle-Closure
[Two variants in MYOC and CYP1B1 genes in a Chinese family with primary angle-closure glaucoma.]
Glaucoma, Open-Angle
A novel MYOC heterzygous mutation identified in a Chinese Uygur pedigree with primary open-angle glaucoma.
Glaucoma, Open-Angle
A polymorphism in the CYP1B1 promoter is functionally associated with primary congenital glaucoma.
Glaucoma, Open-Angle
Analysis of CYP1B1 sequence alterations in patients with primary open-angle glaucoma of Saudi origin.
Glaucoma, Open-Angle
Association between CYP1A1m1 gene polymorphism and primary open-angle glaucoma.
Glaucoma, Open-Angle
Association of a common coding polymorphism (N453S) of the cytochrome P450 1B1 (CYP1B1) gene with optic disc cupping and visual field alteration in French patients with primary open-angle glaucoma.
Glaucoma, Open-Angle
Association of single nucleotide polymorphisms in the CYP1B1 gene with the risk of primary open-angle glaucoma: a meta-analysis.
Glaucoma, Open-Angle
Biallelic CPAMD8 Variants Are a Frequent Cause of Childhood and Juvenile Open-Angle Glaucoma.
Glaucoma, Open-Angle
Clinical application of NGS-based SNP haplotyping for the preimplantation genetic diagnosis of primary open angle glaucoma.
Glaucoma, Open-Angle
CYP1B1 Mutations are a Major Contributor to Juvenile-Onset Open Angle Glaucoma in Saudi Arabia.
Glaucoma, Open-Angle
CYP1B1 mutations in French patients with early-onset primary open-angle glaucoma.
Glaucoma, Open-Angle
Detection of mutations in MYOC, OPTN, NTF4, WDR36 and CYP1B1 in Chinese juvenile onset open-angle glaucoma using exome sequencing.
Glaucoma, Open-Angle
Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene.
Glaucoma, Open-Angle
Evaluation of the CYP1B1 gene as a candidate gene in beagles with primary open-angle glaucoma (POAG).
Glaucoma, Open-Angle
Functional analysis of CYP1B1 mutations and association of heterozygous hypomorphic alleles with primary open-angle glaucoma.
Glaucoma, Open-Angle
Functional and Structural Analyses of CYP1B1 Variants Linked to Congenital and Adult-Onset Glaucoma to Investigate the Molecular Basis of These Diseases.
Glaucoma, Open-Angle
Gene expression profiles of human trabecular meshwork cells induced by triamcinolone and dexamethasone.
Glaucoma, Open-Angle
Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma.
Glaucoma, Open-Angle
Heterozygous loss of function variants in CYP1B1 predispose to primary open angle glaucoma.
Glaucoma, Open-Angle
Identification of novel CYP1B1 gene mutations in patients with primary congenital and primary open-angle glaucoma.
Glaucoma, Open-Angle
Leu432Val polymorphism in CYP1B1 as a susceptible factor towards predisposition to primary open-angle glaucoma.
Glaucoma, Open-Angle
Molecular basis for involvement of CYP1B1 in MYOC upregulation and its potential implication in glaucoma pathogenesis.
Glaucoma, Open-Angle
Mutation spectrum of CYP1B1 in Chinese patients with primary open-angle glaucoma.
Glaucoma, Open-Angle
Mutation spectrum of the CYP1B1 gene for congenital glaucoma in the Japanese population.
Glaucoma, Open-Angle
Mutations in the CYP1B1 gene may contribute to juvenile-onset open-angle glaucoma.
Glaucoma, Open-Angle
No association of genetic polymorphisms in CYP1B1 with primary open-angle glaucoma: a meta- and gene-based analysis.
Glaucoma, Open-Angle
Occurrence of CYP1B1 Mutations in Juvenile Open-Angle Glaucoma With Advanced Visual Field Loss.
Glaucoma, Open-Angle
Occurrence of MYOC and CYP1B1 variants in juvenile open angle glaucoma Brazilian patients.
Glaucoma, Open-Angle
Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients.
Glaucoma, Open-Angle
Role of CYP1B1, p.E229K and p.R368H mutations among 120 families with sporadic juvenile onset open-angle glaucoma.
Glaucoma, Open-Angle
Roles of CYP2C19 Gene Polymorphisms in Susceptibility to POAG and Individual Differences in Drug Treatment Response.
Glaucoma, Open-Angle
Screening Glaucoma Genes in Adult Glaucoma suggests a multiallelic contribution of CYP1B1 to Open Angle Glaucoma Phenotypes.
Glaucoma, Open-Angle
Screening of common CYP1B1 mutations in Iranian POAG patients using a microarray-based PrASE protocol.
Glaucoma, Open-Angle
Screening of CYP1B1 Arg368His as predominant mutation in North Indian primary open angle glaucoma and juvenile onset glaucoma patients.
Glaucoma, Open-Angle
Sequence analysis of MYOC and CYP1B1 in a Chinese pedigree of primary open-angle glaucoma.
Glaucoma, Open-Angle
Single nucleotide polymorphism of MYOC affected the severity of primary open angle glaucoma.
Glaucoma, Open-Angle
Tag SNPs detect association of the CYP1B1 gene with primary open angle glaucoma.
Glaucoma, Open-Angle
The p.Gly61Glu Mutation in CYP1B1 Affects the Extracellular Matrix in Glaucoma Patients.
Glaucoma, Open-Angle
[From gene to disease; primary open-angle glaucoma and three known genes: MYOC, CYP1B1 and OPTN]
Glaucoma, Open-Angle
[Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg]
Glioblastoma
Antiangiogenic effect of inhibitors of cytochrome P450 on rats with glioblastoma multiforme.
Glioblastoma
Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target.
Glioblastoma
Glutathione S-Transferases and Cytochrome P450 Enzyme Expression in Patients with Intracranial Tumors: Preliminary Report of 55 Patients.
Glioblastoma
MGMT- and P450 3A-inhibitors do not sensitize glioblastoma cell cultures against nitrosoureas.
Glioblastoma
miR-204 functions as a tumor suppressor gene, at least partly by suppressing CYP27A1 in glioblastoma.
Glioblastoma
P450 enzyme inducing and non-enzyme inducing antiepileptics in glioblastoma patients treated with standard chemotherapy.
Glioblastoma
Primary neural stem/progenitor cells expressing endostatin or cytochrome P450 for gene therapy of glioblastoma.
Glioblastoma
Rabbit cytochrome P450 4B1: A novel prodrug activating gene for pharmacogene therapy of hepatocellular carcinoma.
Glioblastoma
Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potential.
Glioblastoma
Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system.
Glioblastoma
[Apoptosis and differentiation induced with TCLA in rat glioblastoma cells in vitro]
Glioma
?-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function.
Glioma
A population-based case-control study of the CYP2D6 and GSTT1 polymorphisms and malignant brain tumors.
Glioma
ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.
Glioma
Accumulation of mitochondrial P450MT2, NH(2)-terminal truncated cytochrome P4501A1 in rat brain during chronic treatment with beta-naphthoflavone. A role in the metabolism of neuroactive drugs.
Glioma
Amplification and expression of splice variants of the gene encoding the P450 cytochrome 25-hydroxyvitamin D(3) 1,alpha-hydroxylase (CYP 27B1) in human malignant glioma.
Glioma
An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors.
Glioma
Augmentation of chemotherapy-triggered glioma cell apoptosis by blockade of arachidonic acid metabolism-the potential role of ceramide accumulation.
Glioma
CYP19 expression is induced by 2,3,7,8-tetrachloro-dibenzo-para-dioxin in human glioma cells.
Glioma
Effect of Nicotine on CYP2B1 Expression in a Glioma Animal Model and Analysis of CYP2B6 Expression in Pediatric Gliomas.
Glioma
Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene.
Glioma
Expression and induction of cytochrome P-450 1A1 and P-450 2D subfamily in the rat glioma C6 cell line.
Glioma
Expression, induction and regulation of the cytochrome P450 monooxygenase system in the rat glioma C6 cell line.
Glioma
Gene therapy for malignant gliomas using replication incompetent retroviral and adenoviral vectors encoding the cytochrome P450 2B1 gene together with cyclophosphamide.
Glioma
Genetic polymorphisms in glutathione S-transferase mu and theta, N-acetyltransferase, and CYP1A1 and risk of gliomas.
Glioma
Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors.
Glioma
Glutamate affects the CYP1B1- and CYP2U1-mediated hydroxylation of arachidonic acid metabolism via astrocytic mGlu5 receptor.
Glioma
Glutathione S-transferases and cytochrome P450 detoxifying enzyme distribution in human cerebral glioma.
Glioma
Identification of cytochromes P450 1A2, 2A1, 2C7, 2E1 in rat glioma C6 cell line by RT-PCR and specific restriction enzyme digestion.
Glioma
Identification of inducible mixed function oxidase system in rat glioma C6 cell line.
Glioma
Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1.
Glioma
Novel Functional Association of Serine Palmitoyltransferase Subunit 1-A Peptide in Sphingolipid Metabolism with Cytochrome P4501A1 Transactivation and Proliferative Capacity of the Human Glioma LN18 Brain Tumor Cell Line.
Glioma
P450 enzyme-inducing and non-enzyme-inducing antiepileptic drugs for seizure prophylaxis after glioma resection surgery: a meta-analysis.
Glioma
Perioperative levetiracetam for prevention of seizures in supratentorial brain tumor surgery.
Glioma
Phase I/II trial of pyrazoloacridine and carboplatin in patients with recurrent glioma: a North Central Cancer Treatment Group trial.
Glioma
Physiological role of the N-terminal processed P4501A1 targeted to mitochondria in erythromycin metabolism and reversal of erythromycin-mediated inhibition of mitochondrial protein synthesis.
Glioma
Prodrug-activating Gene Therapy with Rabbit Cytochrome P450 4B1/4-Ipomeanol or 2-Aminoanthracene System in Glioma Cells.
Glioma
The aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl induces distinct patterns of gene expression between hepatoma and glioma cells: chromatin remodeling as a mechanism for selective effects.
Glioma
Towards a complete picture of splice variants of the gene for 25-hydroxyvitamin D31alpha-hydroxylase in brain and skin cancer.
Glioma
Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen.
Gliosarcoma
Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy.
Gliosarcoma
Enantioselective metabolism and cytotoxicity of R-Ifosfamide and S-Ifosfamide by tumor cell-expressed cytochromes P450.
Gliosarcoma
Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11.
Gliosarcoma
Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model.
Gliosarcoma
Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy.
Gliosarcoma
Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors.
Gliosarcoma
Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene.
Gliosarcoma
Sustained P450 expression and prodrug activation in bolus cyclophosphamide-treated cultured tumor cells. Impact of prodrug schedule on P450 gene-directed enzyme prodrug therapy.
Glomerulonephritis, Membranous
Clinical observation on the effect of Wuzhi soft capsule on FK506 concentration in membranous nephropathy patients.
Glomerulonephritis, Membranous
Cytochrome P450 2B1 mediates complement-dependent sublytic injury in a model of membranous nephropathy.
Glomerulonephritis, Membranous
Effects of CYP3A5 Polymorphisms on Efficacy and Safety of Tacrolimus Therapy in Patients with Idiopathic Membranous Nephropathy.
Glucose Intolerance
CYP1B1 deficiency ameliorates obesity and glucose intolerance induced by high fat diet in adult C57BL/6J mice.
Glucose Intolerance
Effect of a high-calorie diet and constant light exposure on female reproduction, metabolism and immune inflammation: A comparative study of different mouse models.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa.
Glucosephosphate Dehydrogenase Deficiency
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Glucosephosphate Dehydrogenase Deficiency
Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa.
glucuronosyltransferase deficiency
cDNA cloning and characterization of feline CYP1A1 and CYP1A2.
glutathione transferase deficiency
Environmental tobacco smoke, genetic susceptibility, and risk of lung cancer in never-smoking women.
glutathione transferase deficiency
Genetic polymorphism of drug-metabolizing enzymes and susceptibility to oral cancer.
glutathione transferase deficiency
Urinary 1-hydroxypyrene level relative to vehicle exhaust exposure mediated by metabolic enzyme polymorphisms.
Goiter, Nodular
Aberrant DNA methylation of drug metabolism and transport genes in nodular goiter.
Goiter, Nodular
[DIO2, TPO, CYP1A1 AND CYP1A2 gene polymorphism in women with thyroid disease].
Gonadal Dysgenesis
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
Gonadal Dysgenesis
Roles of forkhead box protein L2 (foxl2) during gonad differentiation and maintenance in a fish, the olive flounder (Paralichthys olivaceus).
Gout
Colchicine-antimicrobial drug interactions: what pharmacists need to know in treating gout.
Gout
Frequency of CYP2C9 polymorphisms in polynesian people and potential relevance to management of gout with benzbromarone.
Gout
Main contribution of UGT1A1 and CYP2C9 in the metabolism of UR-1102, a novel agent for the treatment of gout.
Gout
Mediation analysis to understand genetic relationships between habitual coffee intake and gout.
Gout
Repurposing of Drugs for Antibacterial Activities on Selected ESKAPE Bacteria Staphylococcus aureus and Pseudomonas aeruginosa.
Gout
[Association of single nucleotide polymorphisms of cytochrome P450 gene with susceptibility to gout in ethnic Han males from coastal regions of Shandong province].
Graft vs Host Disease
Cytochrome P450 1A2 is a target antigen in hepatitic graft-versus-host disease.
Graft vs Host Disease
Impact of CYP3A5, POR, and CYP2C19 Polymorphisms on Trough Concentration to Dose Ratio of Tacrolimus in Allogeneic Hematopoietic Stem Cell Transplantation.
Granuloma
Alterations of hepatic microsomal enzymes in the early phase of murine schistosomiasis.
Granulosa Cell Tumor
Expression of P450 Aromatase in Granulosa Cell Tumors and Sertoli-Stromal Cell Tumors of the Ovary: Which Cells Are Responsible for Estrogenesis?
Granulosa Cell Tumor
Immunohistochemical studies of steroidogenic enzymes (aromatase, 17 alpha-hydroxylase and cholesterol side-chain cleavage cytochromes P-450) in sex cord-stromal tumors of the ovary.
Granulosa Cell Tumor
Immunolocalization of aromatase P-450 in ovarian tissue from pregnant and nonpregnant mares and in ovarian tumours.
Granulosa Cell Tumor
Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads.
Graves Disease
Genetic polymorphisms associated with cigarette smoking and the risk of Graves' disease.
Graves Disease
MATERNAL GRAVES DISEASE AND ABNORMAL CYP2D6 GENOTYPE WITH FETAL HYPERTHYROIDISM.
Gynecomastia
Dominant transmission of prepubertal gynecomastia due to serum estrone excess: hormonal, biochemical, and genetic analysis in a large kindred.
Gynecomastia
Genetic variants of estrogen beta and leptin receptors may cause gynecomastia in adolescent.
Gynecomastia
Multiple structural and functional abnormalities in the p450 aromatase expressing transgenic male mice are ameliorated by a p450 aromatase inhibitor.
Gynecomastia
Studies on the interactions between drug and estrogen. II. On the inhibitory effect of 29 drugs reported to induce gynecomastia on the oxidation of estradiol at C-2 or C-17.
Hallucinations
Venlafaxine-propafenone interaction resulting in hallucinations and psychomotor agitation.
Hallucinations
[Antituberculosis drugs toxicity in patients treated for latent tuberculosis infection.]
Hamartoma
Aryl Hydrocarbon Receptor Activation in Acne Vulgaris Skin: A Case Series from the Region of Naples, Italy.
Hamartoma
The cutaneous lesions of dioxin exposure: lessons from the poisoning of Victor Yushchenko.
Hand-Foot Syndrome
Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity.
Hand-Foot Syndrome
[Validation of genetic polymorphisms associated to the toxicity of chemotherapy in colorectal cancer patients].
Head and Neck Neoplasms
Association and treatment response to capecitabine-based chemoradiotherapy with CYP2C9 polymorphism in head and neck cancer.
Head and Neck Neoplasms
Association of CYP1A1 and CYP2D6 gene polymorphisms with head and neck cancer in Tunisian patients.
Head and Neck Neoplasms
Association of cytochrome P450 1B1 haplotypes with head and neck cancer risk.
Head and Neck Neoplasms
Association of polymorphism in cytochrome P450 2C9 with susceptibility to head and neck cancer and treatment outcome.
Head and Neck Neoplasms
Association of poor metabolizers of cytochrome P450 2C19 with head and neck cancer and poor treatment response.
Head and Neck Neoplasms
Combined effect of smoking and polymorphisms in tobacco carcinogen-metabolizing enzymes CYP1A1 and GSTM1 on the head and neck cancer risk in North Indians.
Head and Neck Neoplasms
CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer.
Head and Neck Neoplasms
Cytochrome P450 2E1 and head and neck cancer: Interaction with genetic and environmental risk factors.
Head and Neck Neoplasms
Cytochrome P450 interactions in human cancers: new aspects considering CYP1B1.
Head and Neck Neoplasms
Effects of cytochrome P450 1A1 and uridine-diphosphate-glucuronosyltransferase 1A1 allelic polymorphisms on the risk of development and the prognosis of head and neck cancers.
Head and Neck Neoplasms
Expression of xenobiotic metabolizing genes in head and neck cancer tissues.
Head and Neck Neoplasms
Functional CYP1A1 genetic variants, alone and in combination with smoking, contribute to development of head and neck cancers.
Head and Neck Neoplasms
Genetic polymorphism of N-acetyltransferase-2, glutathione S-transferase-M1, and cytochromes P450IIE1 and P450IID6 in the susceptibility to head and neck cancer.
Head and Neck Neoplasms
Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer.
Head and Neck Neoplasms
Glutathione S-transferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions.
Head and Neck Neoplasms
GSTM1, GSTT1, GSTP1, CYP1A1, and NAT1 polymorphisms, tobacco use, and the risk of head and neck cancer.
Head and Neck Neoplasms
Hypermethylation of carcinogen metabolism genes, CYP1A1, CYP2A13 and GSTM1 genes in head and neck cancer.
Head and Neck Neoplasms
Impact of CYP2D6 activity and cachexia progression on enantiomeric alteration of plasma tramadol and its demethylated metabolites and their relationships with central nervous system symptoms in head and neck cancer patients.
Head and Neck Neoplasms
Improvement of cyclophosphamide activation by CYP2B6 mutants: from in silico to ex vivo.
Head and Neck Neoplasms
Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India.
Head and Neck Neoplasms
Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response.
Head and Neck Neoplasms
Interactions Among Genetic Variants in Tobacco Metabolizing Genes and Smoking Are Associated with Head and Neck Cancer Susceptibility in North Indians.
Head and Neck Neoplasms
Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer.
Head and Neck Neoplasms
Meta-analyses of the effect of cytochrome P450 2E1 gene polymorphism on the risk of head and neck cancer.
Head and Neck Neoplasms
Mutational analysis of xenobiotic metabolizing genes (CYP1A1 and GSTP1) in sporadic head and neck cancer patients.
Head and Neck Neoplasms
Polymorphism in cytochrome P450 2A6 and glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome.
Head and Neck Neoplasms
Polymorphism in cytochrome P4501A1 is significantly associated with head and neck cancer risk.
Head and Neck Neoplasms
Polymorphisms in the human cytochrome P450 and arylamine N-acetyltransferase: susceptibility to head and neck cancers.
Head and Neck Neoplasms
Re: Association of polymorphism in cytochrome P450 2C9 with susceptibility to head and neck cancer and treatment outcome: Pragmatic use of Hardy-Weinberg equilibrium and statistical interaction analysis.
Head and Neck Neoplasms
Relevance of glutathione S-transferase M1 and cytochrome P450 1A1 genetic polymorphisms to the development of head and neck cancers.
Head and Neck Neoplasms
Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer.
Head and Neck Neoplasms
The association of the CYP1A1 Ile462Val polymorphism with head and neck cancer risk: evidence based on a cumulative meta-analysis.
Head and Neck Neoplasms
The cytochrome P450 2D6 (CYP2D6) gene polymorphism among breast and head and neck cancer patients.
Head and Neck Neoplasms
The PstI/RsaI and DraI polymorphisms of CYP2E1 and head and neck cancer risk: a meta-analysis based on 21 case-control studies.
Head and Neck Neoplasms
The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells.
Head and Neck Neoplasms
Tobacco carcinogen-metabolizing genes CYP1A1, GSTM1, and GSTT1 polymorphisms and their interaction with tobacco exposure influence the risk of head and neck cancer in Northeast Indian population.
Head and Neck Neoplasms
[First results on the influence of polymorphisms at glutathione S-transferase, cytochrome P450, and tumor necrosis factor gene loci on the development of multiple head and neck cancer]
Head and Neck Neoplasms
[Influence of glutathione s-transferase and cytochrome p450 polymorphisms on prognosis of head and neck cancer]
Head Injuries, Penetrating
[Disorders of olfactory function in penetrating head injuries sustained during war]
Healthcare-Associated Pneumonia
Functional polymorphisms in the CYP1A1, ACE, and IL-6 genes contribute to susceptibility to community-acquired and nosocomial pneumonia.
Healthcare-Associated Pneumonia
Genetic susceptibility to nosocomial pneumonia, acute respiratory distress syndrome and poor outcome in patients at risk of critical illness.
Hearing Loss
Acute and Chronic Molecular Signatures and Associated Symptoms of Blast Exposure in Military Breachers.
Hearing Loss
Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers.
Heart Arrest
Cardiac Arrest and Therapeutic Hypothermia Interaction with Isoform-specific Cytochrome P450 Drug Metabolism.
Heart Arrest
Dynamic determination of functional liver capacity with the LiMAx test in post-cardiac arrest patients undergoing targeted temperature management-A prospective trial.
Heart Arrest
Effect of Hypothermia and Targeted Temperature Management on Drug Disposition and Response Following Cardiac Arrest: A Comprehensive Review of Preclinical and Clinical Investigations.
Heart Arrest
Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system.
Heart Arrest
Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest.
Heart Arrest
Therapeutic hypothermia-induced pharmacokinetic alterations on CYP2E1 chlorzoxazone-mediated metabolism in a cardiac arrest rat model*
Heart Arrest
Therapeutic hypothermia-induced pharmacokinetic alterations on CYP2E1 chlorzoxazone-mediated metabolism in a cardiac arrest rat model.
Heart Block
Complete Heart Block Secondary to Flecainide Toxicity: Is It Time for CYP2D6 Genotype Testing?
Heart Block
First-Degree Atrioventricular Block with Tachycardia from Paliperidone and Mirtazapine Overdose.
Heart Defects, Congenital
Associations and interaction effects of maternal smoking and genetic polymorphisms of cytochrome P450 genes with risk of congenital heart disease in offspring: A case-control study.
Heart Defects, Congenital
Genetic and clinical determinants influencing warfarin dosing in children with heart disease.
Heart Diseases
Evaluation of effects of polymorphism for metabolic enzymes on pharmacokinetics of carvedilol by population pharmacokinetic analysis.
Heart Diseases
Genetic and clinical determinants influencing warfarin dosing in children with heart disease.
Heart Diseases
Knockdown of cytochrome P450 2E1 inhibits oxidative stress and apoptosis in the cTnT(R141W) dilated cardiomyopathy transgenic mice.
Heart Diseases
Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes.
Heart Diseases
Pharmacokinetics of dl-praeruptorin A after single-dose intravenous administration to rats with liver cirrhosis.
Heart Diseases
Polymorphisms in genes encoding acetylsalicylic acid metabolizing enzymes are unrelated to upper gastrointestinal health in cardiovascular patients on acetylsalicylic acid.
Heart Failure
2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy.
Heart Failure
Altered pharmacokinetics and excessive hypotensive effect of candesartan in a patient with the CYP2C91/3 genotype.
Heart Failure
An investigation of CYP2D6 genotype and response to metoprolol CR/XL during dose titration in patients with heart failure: a MERIT-HF substudy.
Heart Failure
Cilostazol: new drug. Intermittent claudication: too little efficacy, too many risks.
Heart Failure
CYP2D6 Genetic Variation and Beta-Blocker Maintenance Dose in Patients with Heart Failure.
Heart Failure
CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPK?2 and enhancing nuclear translocation of Akt1.
Heart Failure
Cytochrome P-450 and hepatic drug biotransformation during progressive cardiac disease in cardiomyopathic hamsters.
Heart Failure
Cytochrome P450 2C9 is involved in flow-dependent vasodilation of peripheral conduit arteries in healthy subjects and in patients with chronic heart failure.
Heart Failure
Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway.
Heart Failure
Early Changes in Cytochrome P450s and Their Associated Arachidonic Acid Metabolites Play a Crucial Role in the Initiation of Cardiac Hypertrophy Induced by Isoproterenol.
Heart Failure
Effect of fluoxetine on carvedilol pharmacokinetics, CYP2D6 activity, and autonomic balance in heart failure patients.
Heart Failure
Evaluation and Clinical Implication of Zhenwu Decoction on Seven Cytochrome P450 Enzyme in Chronic Heart Failure Rats.
Heart Failure
Frequency of genetic polymorphism for adrenergic receptor beta and cytochrome p450 2D6 enzyme, and effects on tolerability of beta-blocker therapy in heart failure with reduced ejection fraction patients: The Beta GenTURK study.
Heart Failure
Genetic Variation of Hepatic Enzymes Influence on ?-Blocker Dose in Patients With Reduced Ejection Fraction Heart Failure.
Heart Failure
Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone.
Heart Failure
Impact of CYP3A5 genotype on tolvaptan pharmacokinetics and their relationships with endogenous markers of CYP3A activity and serum sodium level in heart failure patients.
Heart Failure
Increased risk of congestive heart failure in patients with acetaminophen poisoning: A nationwide cohort study.
Heart Failure
Knockdown of cytochrome P450 2E1 inhibits oxidative stress and apoptosis in the cTnT(R141W) dilated cardiomyopathy transgenic mice.
Heart Failure
Modulation of cardiac and hepatic cytochrome P450 enzymes during heart failure.
Heart Failure
Molecular chaperone, HSP60, and cytochrome P450 2E1 co-expression in dilated cardiomyopathy.
Heart Failure
Novel Synthetic Analogues of 19(S/R)-Hydroxyeicosatetraenoic Acid Exhibit Noncompetitive Inhibitory Effect on the Activity of Cytochrome P450 1A1 and 1B1.
Heart Failure
Relation of ADRB1, CYP2D6, and UGT1A1 polymorphisms with dose of, and response to, carvedilol or metoprolol therapy in patients with chronic heart failure.
Heart Failure
Stereoselective metabolism of racemic carvedilol by UGT1A1 and UGT2B7, and effects of mutation of these enzymes on glucuronidation activity.
Heart Failure
Variation in the CYP2D6 genotype is not associated with carvedilol dose changes in patients with heart failure.
Heart Failure
[Polymorphisms of genesencoding enzymes of the xenobiotic detoxification system and the risk of infectious endocarditis].
Heart Failure, Diastolic
The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction.
Heart Failure, Systolic
An investigation of CYP2D6 genotype and response to metoprolol CR/XL during dose titration in patients with heart failure: a MERIT-HF substudy.
Heart Failure, Systolic
CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure.
Heart Valve Diseases
Prevalence of CYP2C9 and VKORC1 mutation in patients with valvular heart disease in northern Thailand.
Hemangioma
Effect of 22 Novel Cytochrome P450 2D6 (CYP2D6) Variants Found in the Chinese Population on Hemangeol Metabolism In Vitro.
Hemangioma
Genotyping for CYP2D6 in Patients with Infantile Hemangiomas Refractory to Topical Timolol.
Hemangioma
Influence of Cytochrome P450 2D6 Polymorphisms on the Efficacy of Oral Propranolol in Treating Infantile Hemangioma.
Hemangioma, Cavernous, Central Nervous System
Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1.
Hematologic Neoplasms
Aberrant DNA methylation of key genes and Acute Lymphoblastic Leukemia.
Hematologic Neoplasms
Effect of CYP3A4, CYP3A5, and ABCB1 Polymorphisms on Intravenous Tacrolimus Exposure and Adverse Events in Adult Allogeneic Stem Cell Transplant Patients.
Hematologic Neoplasms
Identification of a new HLA-A*0201-restricted cryptic epitope from CYP1B1.
Hematologic Neoplasms
Pharmacogenetics of cyclophosphamide in patients with hematological malignancies.
Hematologic Neoplasms
Voriconazole and its clinical potential in the prophylaxis of systemic fungal infection in patients with hematologic malignancies: a perspective review.
Hematuria
CYP1A1 expression and organochlorine pesticides level in the etiology of bladder cancer in North Indian population.
Hemochromatosis
Effect of hemochromatosis on hepatic cytochrome P450 and antipyrine metabolism in humans.
Hemochromatosis
Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans.
Hemochromatosis
Role of iron in alcoholic liver disease: introduction and summary of the symposium.
Hemochromatosis
[Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs].
Hemorrhagic Stroke
Metabolomic profiling of fatty acid biomarkers for intracerebral hemorrhage stroke.
Hepatic Encephalopathy
Influence of different substrates in detoxification activity of adult rat hepatocytes in long-term culture: implications for transplantation.
Hepatic Insufficiency
Albumin is a secret factor involved in multidirectional interactions among the serotoninergic, immune and endocrine systems that supervises the mechanism of CYP1A and CYP3A regulation in the liver.
Hepatic Insufficiency
Altered cytokine profile under control of the serotonergic system determines the regulation of CYP2C11 and CYP3A isoforms.
Hepatic Insufficiency
Olanzapine prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current.
Hepatic Insufficiency
The impact of serotonergic system dysfunction on the regulation of P4501A isoforms during liver insufficiency and consequences for thyroid hormone homeostasis.
Hepatic Insufficiency
[Pharmacokinetics and pharmacodynamics: interactions and adverse effects. Comparison with other echinocandins]
Hepatitis
Anti-liver microsomes autoantibodies and dihydralazine-induced hepatitis: specificity of autoantibodies and inductive capacity of the drug.
Hepatitis
Anti-LKM-1 antibodies determined by use of recombinant P450 2D6 in ELISA and western blot and their association with anti-HCV and HCV-RNA.
Hepatitis
Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera.
Hepatitis
Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2.
Hepatitis
Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease.
Hepatitis
Autoantibodies associated with volatile anesthetic hepatitis found in the sera of a large cohort of pediatric anesthesiologists.
Hepatitis
Chronic active hepatitis associated with vitiligo, nail dystrophy, alopecia and a new variant of LKM antibodies.
Hepatitis
Correlation of induced drug metabolism with titer of duck hepatitis virus in chickens.
Hepatitis
CYP2A5 Induction and Hepatocellular Stress: An Adaptive Response to Perturbations of Heme Homeostasis.
Hepatitis
Cytochrome P450 2A6 is associated with macrophage polarization and is a potential biomarker for hepatocellular carcinoma.
Hepatitis
Cytochrome P450 2A6: a new hepatic autoantigen in patients with chronic hepatitis C virus infection.
Hepatitis
Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications.
Hepatitis
Cytochrome P450 enzymes and UDP-glucuronosyltransferases as hepatocellular autoantigens.
Hepatitis
Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases.
Hepatitis
Cytochromes P450 and UDP-glucuronosyl-transferases as hepatocellular autoantigens.
Hepatitis
Cytochromes P450 and uridine triphosphate-glucuronosyltransferases: model autoantigens to study drug-induced, virus-induced, and autoimmune liver disease.
Hepatitis
Dihydralazine-induced inactivation of cytochrome P450 enzymes in rat liver microsomes.
Hepatitis
Distinct time courses of increase in cytochromes P450 1A2, 2A5 and glutathione S-transferases during the progressive hepatitis associated with Helicobacter hepaticus.
Hepatitis
Drug metabolism in liver disease: activity of hepatic microsomal metabolizing enzymes.
Hepatitis
Drug-induced liver injury associated with antiretroviral therapy that includes HIV-1 protease inhibitors.
Hepatitis
Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.
Hepatitis
Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons.
Hepatitis
Expression of autoantibodies to specific cytochromes P450 in a case of disulfiram hepatitis.
Hepatitis
Expression of Cytochrome P450 2A5 in a C57BL/6J Mouse Model of Nonalcoholic Fatty Liver Disease.
Hepatitis
Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.
Hepatitis
Expression of cytochrome P450 in LEC rats during the development of hereditary hepatitis and hepatoma.
Hepatitis
Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients.
Hepatitis
Hepatic cytochrome P450 and related drug biotransformation during an outbreak of mouse hepatitis virus in a colony of Swiss BALB/c mice.
Hepatitis
Hepatoprotection by dimethyl sulfoxide. III. Role of inhibition of the bioactivation and covalent bonding of chloroform.
Hepatitis
Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis.
Hepatitis
Identification of a 43-kDa protein in human liver cytosol that binds to the 3'-untranslated region of CYP2A6 mRNA.
Hepatitis
Identification of a Shared Cytochrome p4502E1 Epitope Found in Anesthetic Drug-Induced and Viral Hepatitis.
Hepatitis
Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis.
Hepatitis
Increased oxidative DNA damage and hepatocyte overexpression of specific cytochrome P450 isoforms in hepatitis of mice infected with Helicobacter hepaticus.
Hepatitis
Individuals having variant genotypes of cytochrome P450 2C19 are at increased risk of developing primary liver cancer in Han populations, without infection with the hepatitis virus.
Hepatitis
Interaction of heterogeneous nuclear ribonucleoprotein A1 with cytochrome P450 2A6 mRNA: implications for post-transcriptional regulation of the CYP2A6 gene.
Hepatitis
Interactions of dihydralazine with cytochromes P4501A: a possible explanation for the appearance of anti-cytochrome P4501A2 autoantibodies.
Hepatitis
Interferon therapy in LKM-1 positive patients with chronic hepatitis C: follow-up by a quantitative radioligand assay for CYP2D6 antibody detection.
Hepatitis
Interindividual variability in P450-dependent generation of neoantigens in halothane hepatitis.
Hepatitis
Lack of surface expression for the B-cell autoepitope of cytochrome P450 IID6 evidenced by flow cytometry.
Hepatitis
Liver VDR, CYP2R1 and CYP27A1 expression: Relationship with liver histology and vitamin D3 levels in patients with NASH or HCV hepatitis.
Hepatitis
LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase.
Hepatitis
LKM1 autoantibodies in chronic hepatitis C infection: a case of molecular mimicry?
Hepatitis
Mechanism-based inactivation of cytochrome P450s 1A2 and 3A4 by dihydralazine in human liver microsomes.
Hepatitis
Mice with liver composed of human hepatocytes as an animal model for drug testing.
Hepatitis
Mild hepatitis at recommended doses of acetaminophen in patients with evidence of constitutionally enhanced cytochrome P450 system activity.
Hepatitis
Minimal effect of cytokine-independent hepatitis induced by anti-Fas antibodies on hepatic cytochrome P450 gene expression in mice.
Hepatitis
Opposite behaviors of reactive metabolites of tienilic acid and its isomer toward liver proteins: use of specific anti-tienilic acid-protein adduct antibodies and the possible relationship with different hepatotoxic effects of the two compounds.
Hepatitis
Overexpression of cytochrome P-450 isoforms involved in aflatoxin B1 bioactivation in human liver with cirrhosis and hepatitis.
Hepatitis
Patients with type II autoimmune hepatitis express functionally intact cytochrome P-450 db1 that is inhibited by LKM-1 autoantibodies in vitro but not in vivo.
Hepatitis
Polymorphisms in CYP2E1, GSTM1 and GSTT1 and anti-tuberculosis drug-induced hepatotoxicity.
Hepatitis
Recurrent episodes of acute hepatitis associated with LKM-1 (cytochrome P450 2D6) antibodies in identical twin brothers.
Hepatitis
Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced hepatitis.
Hepatitis
Role of CYP2E1 gene polymorphisms association with hepatitis risk in Northeast India.
Hepatitis
Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets.
Hepatitis
Suppression of cytochrome P450 gene expression in the livers of mice with concanavalin A-induced hepatitis.
Hepatitis
Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury.
Hepatitis
The topography of trifluoroacetylated protein antigens in liver microsomal fractions from halothane treated rats.
Hepatitis
Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid.
Hepatitis
Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.
Hepatitis
Vesicular transport of newly synthesized cytochromes P4501A to the outside of rat hepatocyte plasma membranes.
Hepatitis
Voriconazole-Induced Hepatitis via Simvastatin- and Lansoprazole-Mediated Drug Interactions: A Case Report and Review of the Literature.
Hepatitis
[HEV capsid protein interacts with CYP 2A6 and decreases its coumarin 7-hydroxylation activity]
Hepatitis
[Monooxigenase activity in liver diseases (study based on data of antipyrine metabolism)]
Hepatitis
[Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs].
Hepatitis A
Enzymes as target antigens of liver-specific autoimmunity: the case of cytochromes P450s.
Hepatitis A
Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions.
Hepatitis B
Altered Levels of Cytochrome P450 Genes in Hepatitis B or C Virus-infected Liver Identified by Oligonucleotide Microarray.
Hepatitis B
Autologous NeoHep Derived from Chronic Hepatitis B Virus Patients' Blood Monocytes by Upregulation of c-MET Signaling.
Hepatitis B
Autologous NeoHep Derived From Chronic Hepatitis B Virus Patients' Blood Monocytes by Upregulation of cMET Signaling.
Hepatitis B
Comparison of Circulating, Hepatocyte Specific Messenger RNA and microRNA as Biomarkers for Chronic Hepatitis B and C.
Hepatitis B
Curative Effects of ZHENG-Based Fuzheng-Huayu Tablet on Hepatitis B Caused Cirrhosis Related to CYP1A2 Genetic Polymorphism.
Hepatitis B
Expression of cytochrome P450 1A1/2 and 3A4 in liver tissues of hepatocellular carcinoma cases and controls from Taiwan and their relationship to hepatitis B virus and aflatoxin B1-and 4-aminobiphenyl-DNA adducts.
Hepatitis B
Genetic polymorphisms of CYP2E1 and DNA repair genes HOGG1 and XRCC1: Association with hepatitis B related advanced liver disease and cancer.
Hepatitis B
Hepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis.
Hepatitis B
Liver cancer-related gene CYP2E1 expression in HBV transgenic mice with acute liver injury.
Hepatitis B
Microsomal function in hepatitis B surface antigen healthy carriers: assessment of cytochrome P450 1A2 activity by the 14C-caffeine breath test.
Hepatitis B
Overexpression of cytochrome P-450 isoforms involved in aflatoxin B1 bioactivation in human liver with cirrhosis and hepatitis.
Hepatitis B
The question of ethnic variability and the Darwinian significance of physiological neonatal jaundice in East Asian populations.
Hepatitis B, Chronic
Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infection.
Hepatitis B, Chronic
Comparison of Circulating, Hepatocyte Specific Messenger RNA and microRNA as Biomarkers for Chronic Hepatitis B and C.
Hepatitis B, Chronic
Curative Effects of ZHENG-Based Fuzheng-Huayu Tablet on Hepatitis B Caused Cirrhosis Related to CYP1A2 Genetic Polymorphism.
Hepatitis B, Chronic
Cytochrome P450 1A1 genetic polymorphisms and risk of hepatocellular carcinoma among chronic hepatitis B carriers.
Hepatitis B, Chronic
Cytochrome P450 Genes (CYP2E1 and CYP1A1) Variants and Susceptibility to Chronic Hepatitis B Virus Infection.
Hepatitis B, Chronic
HBx inhibits CYP2E1 gene expression via downregulating HNF4? in human hepatoma cells.
Hepatitis B, Chronic
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Hepatitis B, Chronic
Immunoreactivity to various human cytochrome P450 proteins of sera from patients with autoimmune hepatitis, chronic hepatitis B, and chronic hepatitis C.
Hepatitis B, Chronic
[Relationship between the genetic polymorphism of CYP3A5 gene and the clinical response to Bicyclol in chronic hepatitis B]
Hepatitis C
ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms do not affect methadone maintenance treatment in HCV-positive patients.
Hepatitis C
Association of CYP2B6 Single-Nucleotide Polymorphisms Altering Efavirenz Metabolism With Hepatitis C Virus (HCV) Treatment Relapse Among Human Immunodeficiency Virus/HCV-Coinfected African Americans Receiving Ledipasvir/Sofosbuvir in the ION-4 Trial.
Hepatitis C
Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors.
Hepatitis C
Clinical pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplantation.
Hepatitis C
Comparison of Circulating, Hepatocyte Specific Messenger RNA and microRNA as Biomarkers for Chronic Hepatitis B and C.
Hepatitis C
CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer.
Hepatitis C
CYP24A1 genetic variants in the vitamin D metabolic pathway are involved in the outcomes of hepatitis C virus infection among high-risk Chinese population.
Hepatitis C
Development of cytochrome P450 2D6-specific LKM-autoantibodies following liver transplantation for Wilson's disease -- possible association with a steroid-resistant transplant rejection episode.
Hepatitis C
Differences in anti-LKM-1 autoantibody immunoreactivity to CYP2D6 antigenic sites between hepatitis C virus-negative and -positive patients.
Hepatitis C
Distribution of Polymorphisms in Cytochrome P450 2B6, Histocompatibility Complex P5, Chemokine Coreceptor 5, and Interleukin 28B Genes in Inhabitants from the Central Area of Argentina.
Hepatitis C
Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.
Hepatitis C
Effect of interferon alpha-ribavirin bitherapy on cytochrome P450 1A2 and 2D6 and N-acetyltransferase-2 activities in patients with chronic active hepatitis C.
Hepatitis C
Epitope mapping of cytochrome P4502D6 autoantigen in patients with chronic hepatitis C during alpha-interferon treatment.
Hepatitis C
Genetic polymorphisms of cytochrome P450 in patients with hepatitis C virus-associated hepatocellular carcinoma.
Hepatitis C
Genetic polymorphisms of enzymes related to oral tegafur/uracil therapeutic efficacy in patients with hepatocellular carcinoma.
Hepatitis C
Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells.
Hepatitis C
Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1.
Hepatitis C
Impact of CYP2R1, CYP27A1 and CYP27B1 genetic polymorphisms controlling vitamin D metabolism on susceptibility to hepatitis C virus infection in a high-risk Chinese population.
Hepatitis C
Impact of low-dose ritonavir on danoprevir pharmacokinetics: results of computer-based simulations and a clinical drug-drug interaction study.
Hepatitis C
Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1.
Hepatitis C
Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: In vitro and in vivo correlation.
Hepatitis C
Interferon therapy in LKM-1 positive patients with chronic hepatitis C: follow-up by a quantitative radioligand assay for CYP2D6 antibody detection.
Hepatitis C
LKM1 autoantibodies in chronic hepatitis C infection: a case of molecular mimicry?
Hepatitis C
Minor contribution of CYP3A5 to the metabolism of hepatitis C protease inhibitor paritaprevir in vitro.
Hepatitis C
Molecular mimicry of human cytochrome P450 by hepatitis C virus at the level of cytotoxic T cell recognition.
Hepatitis C
Overexpression of cytochrome P-450 isoforms involved in aflatoxin B1 bioactivation in human liver with cirrhosis and hepatitis.
Hepatitis C
Overlapping but distinct specificities of anti-liver-kidney microsome antibodies in autoimmune hepatitis type II and hepatitis C revealed by recombinant native CYP2D6 and novel peptide epitopes.
Hepatitis C
Patterns of expression of cytochrome P450 genes in progression of hepatitis C virus-associated hepatocellular carcinoma.
Hepatitis C
Regulation of the CYP1A1 gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin but not by beta-naphthoflavone or 3-methylcholanthrene is altered in hepatitis C virus replicon-expressing cells.
Hepatitis C
Ribavirin pharmacokinetics and interleukin 28B plus cytochrome P450 27B1 single-nucleotide polymorphisms as predictors of response to pegylated interferon/ribavirin treatment in patients infected with hepatitis C virus genotype 1/4.
Hepatitis C
Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.
Hepatitis C
Sera of children with hepatitis C infection and anti-liver-kidney microsome-1 antibodies recognize different CYP2D6 epitopes than adults with LKM+/HCV+ sera.
Hepatitis C
Serum autoantibodies against cytochrome P450 2E1 (CYP2E1) predict severity of necroinflammation of recurrent hepatitis C.
Hepatitis C
Successful telaprevir treatment in combination of cyclosporine against recurrence of hepatitis C in the Japanese liver transplant patients.
Hepatitis C
The aryl hydrocarbon receptor-cytochrome P450 1A1 pathway controls lipid accumulation and enhances the permissiveness for hepatitis C virus assembly.
Hepatitis C
The interactions of age, sex, body mass index, genetics, and steroid weight-based doses on tacrolimus dosing requirement after adult kidney transplantation.
Hepatitis C
Two-way interaction study between ritonavirboosted danoprevir, a potent HCV protease inhibitor, and ketoconazole in healthy subjects.
Hepatitis C, Chronic
A major CYP2D6 autoepitope in autoimmune hepatitis type 2 and chronic hepatitis C is a three-dimensional structure homologous to other cytochrome P450 autoantigens.
Hepatitis C, Chronic
A new approach to cytochrome CYP2D6 antibody detection in autoimmune hepatitis type-2 (AIH-2) and chronic hepatitis C virus (HCV) infection: a sensitive and quantitative radioligand assay.
Hepatitis C, Chronic
A randomised study of the effect of danoprevir/ritonavir or ritonavir on substrates of cytochrome P450 (CYP) 3A and 2C9 in chronic hepatitis C patients using a drug cocktail.
Hepatitis C, Chronic
Comparison of cytochrome P4502E1 (CYP2E1) activity and hepatic and lymphocyte mRNA expression in patients with chronic hepatitis C.
Hepatitis C, Chronic
CYP2D6 polymorphism and the presence of anti-LKM-1 in patients with chronic hepatitis C.
Hepatitis C, Chronic
Cytochrome P450 2A6: a new hepatic autoantigen in patients with chronic hepatitis C virus infection.
Hepatitis C, Chronic
Cytochrome P4502E1 (CYP2E1) expression in peripheral blood lymphocytes: evaluation in hepatitis C and diabetes.
Hepatitis C, Chronic
Cytochromes P450 and UDP-glucuronosyl-transferases as hepatocellular autoantigens.
Hepatitis C, Chronic
Cytochromes P450 and uridine triphosphate-glucuronosyltransferases: model autoantigens to study drug-induced, virus-induced, and autoimmune liver disease.
Hepatitis C, Chronic
Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients.
Hepatitis C, Chronic
Differences in antigenic sites, recognized by anti-liver-kidney microsome-1 (LKM-1) autoantibody, between HCV-positive and HCV-negative sera in Japanese patients.
Hepatitis C, Chronic
Dose reduction effective in alleviating symptoms of saquinavir toxicity.
Hepatitis C, Chronic
Drug-drug interactions in the treatment of HCV among people who inject drugs.
Hepatitis C, Chronic
Effect of interferon alpha-ribavirin bitherapy on cytochrome P450 1A2 and 2D6 and N-acetyltransferase-2 activities in patients with chronic active hepatitis C.
Hepatitis C, Chronic
Effect of nuclear receptor downregulation on hepatic expression of cytochrome P450 and transporters in chronic hepatitis C in association with fibrosis development.
Hepatitis C, Chronic
Effect of telaprevir on the metabolism and hepatic uptake of tacrolimus (FK506).
Hepatitis C, Chronic
Effects of multiple-dose pegylated interferon alfa-2b on the activity of drug-metabolizing enzymes in persons with chronic hepatitis C.
Hepatitis C, Chronic
Genetic Polymorphisms of Cytochrome P4501A1 (CYP1A1) and Glutathione S-Transferase P1 (GSTP1) and Risk of Hepatocellular Carcinoma Among Chronic Hepatitis C Patients in Egypt.
Hepatitis C, Chronic
Immunoreactivity to various human cytochrome P450 proteins of sera from patients with autoimmune hepatitis, chronic hepatitis B, and chronic hepatitis C.
Hepatitis C, Chronic
Influence of chronic hepatitis C infection on cytochrome P450 3a4 activity using midazolam as an in vivo probe substrate.
Hepatitis C, Chronic
Interferon therapy in LKM-1 positive patients with chronic hepatitis C: follow-up by a quantitative radioligand assay for CYP2D6 antibody detection.
Hepatitis C, Chronic
Key residues of a major cytochrome P4502D6 epitope are located on the surface of the molecule.
Hepatitis C, Chronic
Liver function parameters in HIV/HCV co-infected patients treated with amprenavir and ritonavir and correlation with plasma levels.
Hepatitis C, Chronic
Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection.
Hepatitis C, Chronic
Ombitasvir/Paritaprevir/Ritonavir Plus Dasabuvir: A Review in Chronic HCV Genotype 1 Infection.
Hepatitis C, Chronic
Role of CYP2D6 polymorphism in predicting liver fibrosis progression rate in Caucasian patients with chronic hepatitis C.
Hepatitis C, Chronic
Steatosis in chronic hepatitis C: association with increased messenger RNA expression of collagen I, tumor necrosis factor-alpha and cytochrome P450 2E1.
Hepatitis C, Chronic
Viral induction of autoimmunity: mechanisms and examples in hepatology.
Hepatitis C, Chronic
[CLINICAL AND ENDOSCOPIC CHARACTERISTICS OF THE GASTRODUODENAL MUCOSAL LESIONS IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION WITH DIFFERENT BODY MASS STATUS].
Hepatitis, Alcoholic
A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease.
Hepatitis, Alcoholic
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice.
Hepatitis, Alcoholic
Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis.
Hepatitis, Alcoholic
[Genetic susceptibility to the development of acute alcoholic hepatitis: role of genetic mutations in dehydrogenase alcohol, aldehyde dehydrogenase and cytochrome P450 2E1]
Hepatitis, Autoimmune
A major CYP2D6 autoepitope in autoimmune hepatitis type 2 and chronic hepatitis C is a three-dimensional structure homologous to other cytochrome P450 autoantigens.
Hepatitis, Autoimmune
A new approach to cytochrome CYP2D6 antibody detection in autoimmune hepatitis type-2 (AIH-2) and chronic hepatitis C virus (HCV) infection: a sensitive and quantitative radioligand assay.
Hepatitis, Autoimmune
A new epitope of CYP2D6 recognized by liver kidney microsomal autoantibody from japanese patients with autoimmune hepatitis.
Hepatitis, Autoimmune
Anti-liver-kidney microsome antibody type 1 recognizes human cytochrome P450 db1.
Hepatitis, Autoimmune
Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2.
Hepatitis, Autoimmune
Autoantibodies associated with acute rejection after liver transplantation for type-2 autoimmune hepatitis.
Hepatitis, Autoimmune
Autoantibody detection in type 2 autoimmune hepatitis using a chimera recombinant protein.
Hepatitis, Autoimmune
Cytochrome P4502B follows a vesicular route to the plasma membrane in cultured rat hepatocytes.
Hepatitis, Autoimmune
Cytochromes P450 and UDP-glucuronosyl-transferases as hepatocellular autoantigens.
Hepatitis, Autoimmune
Detection of anti-LKM-1(anti-CYP2D6) by an enzyme-linked immunosorbent assay in adult patients with chronic liver diseases.
Hepatitis, Autoimmune
Detection on immunoblot of new proteins from the microsomal fraction recognized by anti-liver-kidney microsome antibodies type 1.
Hepatitis, Autoimmune
Development of cytochrome P450 2D6-specific LKM-autoantibodies following liver transplantation for Wilson's disease -- possible association with a steroid-resistant transplant rejection episode.
Hepatitis, Autoimmune
Differences in anti-LKM-1 autoantibody immunoreactivity to CYP2D6 antigenic sites between hepatitis C virus-negative and -positive patients.
Hepatitis, Autoimmune
Differences in antigenic sites, recognized by anti-liver-kidney microsome-1 (LKM-1) autoantibody, between HCV-positive and HCV-negative sera in Japanese patients.
Hepatitis, Autoimmune
Enzymes as target antigens of liver-specific autoimmunity: the case of cytochromes P450s.
Hepatitis, Autoimmune
Epitope mapping of cytochrome P4502D6 autoantigen in patients with chronic hepatitis C during alpha-interferon treatment.
Hepatitis, Autoimmune
Epitope mapping of human CYP1A2 in dihydralazine-induced autoimmune hepatitis.
Hepatitis, Autoimmune
Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model.
Hepatitis, Autoimmune
Frequency and significance of anti-glutathione S-transferase autoantibody (anti-GST A1-1) in autoimmune hepatitis.
Hepatitis, Autoimmune
Heterogeneity of liver/kidney microsomal antibody type 1 in autoimmune hepatitis and hepatitis C virus related liver disease.
Hepatitis, Autoimmune
Identification of the main epitope on human cytochrome P450 IID6 recognized by anti-liver kidney microsome antibody.
Hepatitis, Autoimmune
Immunoreactivity to various human cytochrome P450 proteins of sera from patients with autoimmune hepatitis, chronic hepatitis B, and chronic hepatitis C.
Hepatitis, Autoimmune
Key residues of a major cytochrome P4502D6 epitope are located on the surface of the molecule.
Hepatitis, Autoimmune
LKM-1 sera from autoimmune hepatitis patients that recognize ERp57, carboxylesterase 1 and CYP2D6.
Hepatitis, Autoimmune
LKM1 autoantibodies in chronic hepatitis C infection: a case of molecular mimicry?
Hepatitis, Autoimmune
Molecular mimicry of human cytochrome P450 by hepatitis C virus at the level of cytotoxic T cell recognition.
Hepatitis, Autoimmune
Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis.
Hepatitis, Autoimmune
Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model.
Hepatitis, Autoimmune
Organ-specific and non-organ-specific autoantibodies in children and young adults with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Hepatitis, Autoimmune
Overlapping but distinct specificities of anti-liver-kidney microsome antibodies in autoimmune hepatitis type II and hepatitis C revealed by recombinant native CYP2D6 and novel peptide epitopes.
Hepatitis, Autoimmune
Study of CYP2D6 gene in children with autoimmune hepatitis and P450 IID6 autoantibodies.
Hepatitis, Autoimmune
Target proteins in human autoimmunity: cytochromes P450 and UDP- glucuronosyltransferases.
Hepatitis, Autoimmune
Terbinafine-induced acute autoimmune hepatitis in the setting of hepatitis B virus infection.
Hepatitis, Autoimmune
Viral triggers for autoimmunity: Is the 'glass of molecular mimicry' half full or half empty?
Hepatitis, Autoimmune
[Establishment of a mouse model of autoimmune hepatitis induced by human CYP2D6].
Hepatitis, Chronic
Anti-LKM-1 antibodies determined by use of recombinant P450 2D6 in ELISA and western blot and their association with anti-HCV and HCV-RNA.
Hepatitis, Chronic
Chronic active hepatitis associated with vitiligo, nail dystrophy, alopecia and a new variant of LKM antibodies.
Hepatitis, Chronic
Effect of interferon alpha-ribavirin bitherapy on cytochrome P450 1A2 and 2D6 and N-acetyltransferase-2 activities in patients with chronic active hepatitis C.
Hepatitis, Chronic
In vivo metabolic activity of CYP2C19 and CYP3A in relation to CYP2C19 genetic polymorphism in chronic liver disease.
Hepatitis, Chronic
Lack of surface expression for the B-cell autoepitope of cytochrome P450 IID6 evidenced by flow cytometry.
Hepatitis, Chronic
LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase.
Hepatitis, Chronic
Patients with type II autoimmune hepatitis express functionally intact cytochrome P-450 db1 that is inhibited by LKM-1 autoantibodies in vitro but not in vivo.
Hepatitis, Chronic
Regulation of cytochrome P450 IID by acute phase mediators in C3H/HeJ mice.
Hepatoblastoma
Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells.
Hepatoblastoma
Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells.
Hepatoblastoma
Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7.
Hepatoblastoma
Differential expression of glutamine synthetase and cytochrome P450 isoforms in human hepatoblastoma.
Hepatoblastoma
HepG2-1A2 C2 and C7: Lentivirus vector-mediated stable and functional overexpression of cytochrome P450 1A2 in human hepatoblastoma cells.
Hepatoblastoma
Inducing effects of dioxin-like polychlorinated biphenyls on CYP1A in the human hepatoblastoma cell line HepG2, the rat hepatoma cell line H4IIE, and rat primary hepatocytes: comparison of relative potencies.
Hepatoblastoma
Metabolic activity testing can underestimate acute drug cytotoxicity as revealed by HepG2 cell clones overexpressing cytochrome P450 2C19 and 3A4.
Hepatoblastoma
Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells.
Hepatoblastoma
Optimization of Albumin Secretion and Metabolic Activity of Cytochrome P450 1A1 of Human Hepatoblastoma HepG2 Cells in Multicellular Spheroids by Controlling Spheroid Size.
Hepatoblastoma
Role of nitroreductases but not cytochromes P450 in the metabolic activation of 1-nitropyrene in the HepG2 human hepatoblastoma cell line.
Hepatoblastoma
Selective poisoning of Ctnnb1-mutated hepatoma cells in mouse liver tumors by a single application of acetaminophen.
Hepatoblastoma
Structure-dependent genotoxic potencies of selected pyrrolizidine alkaloids in metabolically competent HepG2 cells.
Hepatoblastoma
Transcriptional control of human cytochrome P1-450 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human tissue culture cell lines.
Hepatoblastoma
Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines.
Hepatolenticular Degeneration
Development of cytochrome P450 2D6-specific LKM-autoantibodies following liver transplantation for Wilson's disease -- possible association with a steroid-resistant transplant rejection episode.
Hepatolenticular Degeneration
Hepatic drug-metabolizing enzymes and drug transporters in Wilson's disease patients with liver failure.
Hepatomegaly
Biochemical and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in immature male and female chickens.
Hepatomegaly
CYP1A2 is not required for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunosuppression.
Hepatomegaly
Early hepatic changes induced in rats by two hepatocarcinogenic organohalogen pesticides: bromopropylate and DDT.
Hepatomegaly
Experimental studies on pharmacology, metabolism and toxicology with tiadenol-disulfoxide. Dissociation of lipid lowering effects and the induction of peroxisomal and microsomal drug-metabolizing enzymes.
Hepatomegaly
Fenofibrate, a ligand for PPARalpha, inhibits aromatase cytochrome P450 expression in the ovary of mouse.
Hepatomegaly
Interactive effects of methyl tertiary-butyl ether (MTBE) and tertiary-amyl methyl ether (TAME), ethanol and some drugs: Triglyceridemia, liver toxicity and induction of CYP (2E1, 2B1) and phase II enzymes in female Wistar rats.
Hepatomegaly
Loss of tumor-promoting activity of unleaded gasoline in N-nitrosodiethylamine-initiated ovariectomized B6C3F1 mouse liver.
Hepatomegaly
Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1.
Hepatomegaly
Toxicological approach for elucidation of clobazam-induced hepatomegaly in male rats.
Hepatomegaly
Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver.
Hepatomegaly
[Changes in the hydroxylating function and structure of the hepatic endoplasmic reticulum of the rat as affected by long-term kordiamin administration]
Hepatorenal Syndrome
Cytochrome P450 metabolites of arachidonic acid in the control of renal function.
Herpes Simplex
Differential cytotoxicity and bystander effect of the rabbit cytochrome P450 4B1 enzyme gene by two different prodrugs: implications for pharmacogene therapy.
Herpes Simplex
Enhanced green fluorescent protein fusion proteins of herpes simplex virus type 1 thymidine kinase and cytochrome P450 4B1: applications for prodrug-activating gene therapy.
Herpes Simplex
Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.
Herpes Simplex
Identification of the main epitope on human cytochrome P450 IID6 recognized by anti-liver kidney microsome antibody.
Herpes Simplex
Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies.
Herpes Simplex
Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene.
Herpes Simplex
Response of the ileum transcriptome to fructo-oligosaccharides in Taiping chickens.
Herpes Simplex
Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity.
Herpes Zoster
A homodimer model can resolve the conundrum as to how cytochrome P450 oxidoreductase and cytochrome b5 compete for the same binding site on cytochrome P450c17.
Herpes Zoster
A novel cell layer without corticosteroid-synthesizing enzymes in rat adrenal cortex: histochemical detection and possible physiological role.
Herpes Zoster
Adrenic acid metabolites as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors.
Herpes Zoster
Calf adrenocortical fasciculata cells secrete aldosterone when placed in primary culture.
Herpes Zoster
Cellular and Molecular Impact of Vitrification Versus Slow Freezing on Ovarian Tissue.
Herpes Zoster
Cloning and expression of a rat cytochrome P-450 11 beta-hydroxylase/aldosterone synthase (CYP11B2) cDNA variant.
Herpes Zoster
Cloning and expression of the rat adrenal cytochrome P-450 11B3 (CYP11B3) enzyme cDNA: preferential 18-hydroxylation over 11 beta-hydroxylation of DOC.
Herpes Zoster
Colocalization of P450 Aromatase and Oxytocin Immunostaining in the Rat Hypothalamus.
Herpes Zoster
Development of adrenal zonation in fetal rats defined by expression of aldosterone synthase and 11beta-hydroxylase.
Herpes Zoster
Differential effects of adrenocorticotropin in vivo on cytochromes P4502D16 and P450c17 in the guinea pig adrenal cortex.
Herpes Zoster
Effects of age and adrenocorticotropin on microsomal enzymes in guinea pig adrenal inner and outer cortices.
Herpes Zoster
Effects of cyclopenta[c]phenanthrene and its derivatives on zona radiata protein, ERalpha, and CYP1A mRNA expression in liver of rainbow trout (Oncorhynchus mykiss Walbaum).
Herpes Zoster
Effects of dietary soy and estrous cycle on adrenal cytochrome p450 1B1 expression and DMBA metabolism in adrenal glands and livers in female Sprague-Dawley rats.
Herpes Zoster
Effects of long term stimulation of ACTH and angiotensin II-secretions on the rat adrenal cortex.
Herpes Zoster
Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria.
Herpes Zoster
Estrogenic effects of selected hydroxy polychlorinated biphenyl congeners in primary culture of Atlantic Salmon (Salmo salar) hepatocytes.
Herpes Zoster
Evaluation of ecotoxicological effects of endocrine disrupters during a four-year survey of the Mediterranean population of swordfish (Xiphias gladius).
Herpes Zoster
Gender and gonadal status differences in zona reticularis expression in marmoset monkey adrenals: Cytochrome b5 localization with respect to cytochrome P450 17,20-lyase activity.
Herpes Zoster
Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.
Herpes Zoster
Immunocytochemical analyses of dehydroepiandrosterone sulfotransferase in cultured human fetal adrenal cells.
Herpes Zoster
Immunohistochemical localization of CYP1A, vitellogenin and Zona radiata proteins in the liver of swordfish (Xiphias gladius L.) taken from the Mediterranean Sea, South Atlantic, South Western Indian and Central North Pacific Oceans.
Herpes Zoster
Induction of steroidogenic enzymes by potassium in cultured rat zona glomerulosa cells depends on calcium influx and intact protein synthesis.
Herpes Zoster
Light and electron microscopic immunohistochemistry of the localization of adrenal steroidogenic enzymes.
Herpes Zoster
Maturational changes in CYP2D16 expression and xenobiotic metabolism in adrenal glands from male and female guinea pigs.
Herpes Zoster
Mitochondrial redox components of human adrenocortical steroid hydroxylases under physiological conditions and in focal hyperplasia of the zone fasciculata.
Herpes Zoster
Molecular Analysis of Endocrine Disruption in Hornyhead Turbot at Wastewater Outfalls in Southern California Using a Second Generation Multi-Species Microarray.
Herpes Zoster
Multisteroid analysis in children with terminal aldosterone biosynthesis defects.
Herpes Zoster
Potential toxicological hazard due to endocrine-disrupting chemicals on Mediterranean top predators: state of art, gender differences and methodological tools.
Herpes Zoster
Regulation of aldosterone synthase cytochrome P450 (CYP11B2) and 11 beta-hydroxylase cytochrome P450 (CYP11B1) expression in rat adrenal zona glomerulosa cells by low sodium diet and angiotensin II receptor antagonists.
Herpes Zoster
Risk of herpes zoster in patients prescribed inhaled corticosteroids: a cohort study.
Herpes Zoster
Target cells for cytochrome p450-catalysed irreversible binding of 7,12-dimethylbenz[a]anthracene (DMBA) in rodent adrenal glands.
Herpes Zoster
Targeted salmon gene array (SalArray): a toxicogenomic tool for gene expression profiling of interactions between estrogen and aryl hydrocarbon receptor signalling pathways.
Herpes Zoster
The expression of CYP1A, vitellogenin and zona radiata proteins in Atlantic salmon (Salmo salar) after oral dosing with two commercial PBDE flame retardant mixtures: absence of short-term responses.
Herpes Zoster
The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation.
Herpes Zoster
Transcriptional response of honey bee larvae infected with the bacterial pathogen Paenibacillus larvae.
Herpes Zoster
Zonal expression of endothelial nitric oxide synthase in sheep and rhesus adrenal cortex.
Hirschsprung Disease
Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population.
Histiocytoma
An Excess of CYP24A1, Lack of CaSR, and a Novel lncRNA Near the PTH Gene Characterize an Ectopic PTH-Producing Tumor.
HIV Infections
CYP1A1 and 1B1-mediated metabolic pathways of dolutegravir, an HIV integrase inhibitor.
HIV Infections
CYP2B6 genotype-directed dosing is required for optimal efavirenz exposure in children 3-36 months with HIV infection.
HIV Infections
Effect of CYP2B6 Gene Polymorphisms on Efavirenz Plasma Concentrations in Chinese Patients with HIV Infection.
HIV Infections
Effect of Seville orange juice and grapefruit juice on indinavir pharmacokinetics.
HIV Infections
Effect of zidovudine therapy in patients with HIV infection on endogenous interferon plasma levels and the hepatic cytochrome P450 enzyme system.
HIV Infections
Exploring CYP2B6 activity by measuring the presence ofnevirapine hydroxy metabolites in plasma.
HIV Infections
Pharmacokinetics and Placental Transfer of Bupivacaine Enantiomers in HIV-Infected Parturient Women on Antiretroviral Therapy.
HIV Infections
Pilot study evaluating the interaction between paclitaxel and protease inhibitors in patients with human immunodeficiency virus-associated Kaposi's sarcoma: an Eastern Cooperative Oncology Group (ECOG) and AIDS Malignancy Consortium (AMC) trial.
HIV Infections
Pyridine-substituted desoxyritonavir is a more potent inhibitor of cytochrome P450 3A4 than ritonavir.
HIV Infections
Tribal ethnicity and CYP2B6 genetics in Ugandan and Zimbabwean populations in the UK: implications for efavirenz dosing in HIV infection.
Hodgkin Disease
Drug interactions between antineoplastic and antiretroviral therapies: Implications and management for clinical practice.
Hodgkin Disease
WebHERV: A Web Server for the Computational Investigation of Gene Expression Associated With Endogenous Retrovirus-Like Sequences.
Hookworm Infections
Hepatic microsomal cytochrome P450 system during experimental hookworm infection.
Huntington Disease
Differences in proteomic profiles between yak and three cattle strains provide insights into molecular mechanisms underlying high-altitude adaptation.
Hydatidiform Mole
Quantitative evaluation of human placental aromatase in abnormal pregnancy--anencephalus and hydatidiform mole.
Hydronephrosis
Localization of cytochrome P450 1A1 in a specific region of hydronephrotic kidney of rat neonates lactationally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Hydrophthalmos
Axenfeld-Rieger Syndrome Associated with Congenital Glaucoma and Cytochrome P4501B1 Gene Mutations.
Hydrophthalmos
Sturge-Weber Syndrome With Congenital Glaucoma and Cytochrome P450 (CYP1B1) Gene Mutations.
Hyperaldosteronism
Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria.
Hyperaldosteronism
Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin.
Hyperalgesia
3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.
Hyperalgesia
Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain.
Hyperalgesia
The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain.
Hyperandrogenism
Association between CYP19 gene SNP rs2414096 polymorphism and polycystic ovary syndrome in Chinese women.
Hyperandrogenism
Current developments in the molecular genetics of the polycystic ovary syndrome.
Hyperandrogenism
Effects of testosterone on PPAR? and P450arom expression in polycystic ovary syndrome patients and related mechanisms.
Hyperandrogenism
Impact of rs2414096 polymorphism of CYP19 gene on susceptibility of polycystic ovary syndrome and hyperandrogenism in Kashmiri women.
Hyperandrogenism
Pathogenesis of polycystic ovary syndrome: evidence for a genetically determined disorder of ovarian androgen production.
Hyperandrogenism
Polycystic ovary syndrome: evidence for a primary disorder of ovarian steroidogenesis.
Hyperandrogenism
Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS.
Hyperandrogenism
SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients.
Hyperandrogenism
Transcutaneous electrical acupoint stimulation alleviates the hyperandrogenism of polycystic ovarian syndrome rats by regulating the expression of P450arom and CTGF in the ovaries.
Hyperandrogenism
[Effect of anti-Müllerian hormone on P450 aromatase mRNA expression in cultured human luteinized granulose cells]
Hypercalcemia
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
Hypercalcemia
25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D.
Hypercalcemia
25-Hydroxyvitamin D3 24-Hydroxylase: A Key Regulator of 1,25(OH)2D3 Catabolism and Calcium Homeostasis.
Hypercalcemia
A Case of "Late Onset" Idiopathic Infantile Hypercalcemia Secondary to Mutations in The CYP24A1 Gene.
Hypercalcemia
A novel CYP24A1 genotype associated to a clinical picture of hypercalcemia, nephrolithiasis and low bone mass.
Hypercalcemia
A rapid screening of a recurrent CYP24A1 pathogenic variant opens the way to molecular testing for Idiopathic Infantile Hypercalcemia (IIH).
Hypercalcemia
A Young Woman with Recurrent Gestational Hypercalcemia and Acute Pancreatitis Due to CYP24A1 Deficiency.
Hypercalcemia
Analysis of vitamin D3 metabolites in survivors of infantile idiopathic hypercalcemia caused by CYP24A1 mutation or SLC34A1 mutation.
Hypercalcemia
Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia.
Hypercalcemia
Biallelic mutations in CYP24A1 or SLC34A1 as a cause of infantile idiopathic hypercalcemia (IIH) with vitamin D hypersensitivity: molecular study of 11 historical IIH cases.
Hypercalcemia
Calcioic acid: In vivo detection and quantification of the terminal C24-oxidation product of 25-hydroxyvitamin D3 and related intermediates in serum of mice treated with 24,25-dihydroxyvitamin D3.
Hypercalcemia
Calcium and bone homeostasis in heterozygous carriers of CYP24A1 mutations: A cross-sectional study.
Hypercalcemia
Calcium pyrophosphate deposition disease revealing a hypersensitivity to vitamin D.
Hypercalcemia
Clinical and biochemical phenotypes of adults with monoallelic and biallelic CYP24A1 mutations: evidence of gene dose effect.
Hypercalcemia
CYP24A1 and SLC34A1 genetic defects associated with idiopathic infantile hypercalcemia: from genotype to phenotype.
Hypercalcemia
CYP24A1 and SLC34A1 Pathogenic Variants Are Uncommon in a Canadian Cohort of Children with Hypercalcemia or Hypercalciuria.
Hypercalcemia
CYP24A1 loss of function: Clinical phenotype of monoallelic and biallelic mutations.
Hypercalcemia
CYP24A1 Mutations in a Cohort of Hypercalcemic Patients: Evidence for a Recessive Trait.
Hypercalcemia
CYP24A1 Variants in Two Chinese Patients with Idiopathic Infantile Hypercalcemia.
Hypercalcemia
CYP3A4 induction by Rifampin: An Alternative Pathway for Vitamin D Inactivation in Patients with CYP24A1 Mutations.
Hypercalcemia
Differential diagnosis of vitamin D-related hypercalcemia using serum vitamin D metabolite profiling.
Hypercalcemia
Discordant Clinical Course of Vitamin-D-Hydroxylase (CYP24A1) Associated Hypercalcemia in Two Adult Brothers With Nephrocalcinosis.
Hypercalcemia
Do the Heterozygous Carriers of a CYP24A1 Mutation Display a Different Biochemical Phenotype Than Wild Types?
Hypercalcemia
Duplex high resolution melting analysis (dHRMA) to detect two hot spot CYP24A1 pathogenic variants (PVs) associated to idiopathic infantile hypercalcemia (IIH).
Hypercalcemia
Erratum to: A novel CYP24A1 genotype associated to a clinical picture of hypercalcemia, nephrolithiasis and low bone mass.
Hypercalcemia
External Quality Assessment of 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) assays.
Hypercalcemia
Family History is Important to Identify Patients with Monogenic Causes of Adult-Onset Chronic Kidney Disease.
Hypercalcemia
Genetic defect in CYP24A1, the vitamin D 24-hydroxylase gene, in a patient with severe infantile hypercalcemia.
Hypercalcemia
Girl with idiopathic childhood hypercalcemia reveals new disease-causing CYP24A1 mutation.
Hypercalcemia
Hereditary Hypercalcemia Caused by a Homozygous Pathogenic Variant in the CYP24A1 Gene: A Case Report and Review of the Literature.
Hypercalcemia
Hypercalcemia due to all trans retinoic acid in the treatment of acute promyelocytic leukemia potentiated by voriconazole.
Hypercalcemia
Hypercalcemia, Hypercalciuria, and Elevated Calcitriol Concentrations with Autosomal Dominant Transmission Due to CYP24A1 Mutations: Effects of Ketoconazole Therapy.
Hypercalcemia
Iatrogenic vitamin D toxicity in an infant - a case report and review of literature.
Hypercalcemia
Idiopathic infantile hypercalcemia: mutations in SLC34A1 and CYP24A1 in two siblings and fathers.
Hypercalcemia
Improved Screening Test for Idiopathic Infantile Hypercalcemia Confirms Residual Levels of Serum 24,25-(OH)
Hypercalcemia
Infantile hypercalcemia with novel compound heterozygous mutation in SLC34A1 encoding renal sodium-phosphate cotransporter 2a: a case report.
Hypercalcemia
Intravenous pamidronate in the treatment of severe idiopathic infantile hypercalcemia.
Hypercalcemia
Kidney function and influence of sunlight exposure in patients with impaired 24-hydroxylation of vitamin D due to CYP24A1 mutations.
Hypercalcemia
Lightwood Syndrome Revisited with a Novel Mutation in CYP24 and Vitamin D Supplement Recommendations.
Hypercalcemia
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
Hypercalcemia
Loss-of-function mutations of CYP24A1, the vitamin D 24- hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis.
Hypercalcemia
Maternal and infantile hypercalcemia caused by vitamin-D-hydroxylase mutations and vitamin D intake.
Hypercalcemia
Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations.
Hypercalcemia
Molecular characterization of a recurrent 10.9?kb CYP24A1 deletion in Idiopathic Infantile Hypercalcemia.
Hypercalcemia
Mutational Spectrum of CYP24A1 Gene in a Cohort of Italian Patients with Idiopathic Infantile Hypercalcemia.
Hypercalcemia
Novel CYP24A1 Mutation in a Young Male Patient with Nephrolithiasis: Case Report.
Hypercalcemia
Promise of vitamin D analogues in the treatment of hyperproliferative conditions.
Hypercalcemia
Re: A Rapid Screening of a Recurrent CYP24A1 Pathogenic Variant Opens the Way to Molecular Testing for Idiopathic Infantile Hypercalcemia (IIH).
Hypercalcemia
Severe hypercalcemic crisis in an infant with idiopathic infantile hypercalcemia caused by mutation in CYP24A1 gene.
Hypercalcemia
Sources of variation evaluation of 24,25(OH)2D levels and the ratio of 25OHD to 24,25(OH)2D in apparently healthy Chinese adults: a multicenter cross-sectional study.
Hypercalcemia
Targeted delivery of 1,25-dihydroxyvitamin D3 to colon tissue and identification of a major 1,25-dihydroxyvitamin D3 glycoside from Solanumglaucophyllum plant leaves.
Hypercalcemia
Therapy-Resistant Hypercalcemia in a Patient with Inactivating CYP24A1 Mutation and Recurrent Nephrolithiasis: Beware of Concomitant Hyperparathyroidism.
Hypercalcemia
Three Sisters With Heterozygous Gene Variants of CYP24A1: Maternal Hypercalcemia, New-Onset Hypertension, and Neonatal Hypoglycemia.
Hypercalcemia
Ultra-rare renal diseases diagnosed with whole-exome sequencing: Utility in diagnosis and management.
Hypercalcemia
Vitamin D receptor activation reduces VCaP xenograft tumor growth and counteracts ERG activity despite induction of TMPRSS2:ERG.
Hypercalcemia
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.
Hypercalcemia
When a maternal heterozygous mutation of the CYP24A1 gene leads to infantile hypercalcemia through a maternal uniparental disomy of chromosome 20.
Hypercalcemia
[Molecular and genetic technologies for the diagnosis of monogenic forms of urinary stone disease: clinical cases].
Hypercholesterolemia
Association of polymorphism in the cytochrome CYP2D6 and the efficacy and tolerability of simvastatin.
Hypercholesterolemia
Construction of a novel expression vector in Pseudonocardia autotrophica and its application to efficient biotransformation of compactin to pravastatin, a specific HMG-CoA reductase inhibitor.
Hypercholesterolemia
Contribution of arachidonic acid metabolites to reduced norepinephrine-induced contractions in hypercholesterolemic rabbit aortas.
Hypercholesterolemia
CYP3A53A allele is associated with reduced lowering-lipid response to atorvastatin in individuals with hypercholesterolemia.
Hypercholesterolemia
Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice.
Hypercholesterolemia
Differential expression of hepatic genes involved in cholesterol homeostasis in high- and low-responding strains of laboratory opossums.
Hypercholesterolemia
Enhancement of hepatic drug biotransformation rate by polychlorinated biphenyls in rats fed cholesterol-rich diet.
Hypercholesterolemia
GENERATION OF HUMAN CHIRAL METABOLITES OF SIMVASTATIN AND LOVASTATIN BY BACTERIAL CYP102A1 MUTANTS.
Hypercholesterolemia
Importance of endothelium-derived hyperpolarizing factor in human arteries.
Hypercholesterolemia
Increased carbon tetrachloride-induced liver injury and fibrosis in FGFR4-deficient mice.
Hypercholesterolemia
Overexpression of cholesterol 7?-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis.
Hypercholesterolemia
Proteomic analysis for the impact of hypercholesterolemia on expressions of hepatic drug transporters and metabolizing enzymes.
Hypercholesterolemia
Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin.
Hypercholesterolemia
Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid.
Hypercholesterolemia
Unusual genetic variants associated with hypercholesterolemia in Argentina.
Hyperemia
Dependency of cortical functional hyperemia to forepaw stimulation on epoxygenase and nitric oxide synthase activities in rats.
Hyperglycemia
Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis.
Hyperglycemia
Differential regulation of hepatic cytochrome P450 monooxygenases in streptozotocin-induced diabetic rats.
Hyperglycemia
Effect of hyperinsulinemia and type 2 diabetes-like hyperglycemia on expression of hepatic cytochrome p450 and glutathione s-transferase isoforms in a New Zealand obese-derived mouse backcross population.
Hyperglycemia
Effect of insulin-mimetic vanadyl sulfate on cytochrome P450 2E1-dependent p-nitrophenol hydroxylation in the liver microsomes of streptozotocin-induced type 1 diabetic rats.
Hyperglycemia
Effects of dapagliflozin in combination with insulin on cytochrome P450 activities in a diabetes type 1 rat model.
Hyperglycemia
In Vitro Evidence for Chronic Alcohol and High Glucose Mediated Increased Oxidative Stress and Hepatotoxicity.
Hyperglycemia
Knockdown of CYP1B1 suppresses the behavior of the extravillous trophoblast cell line HTR-8/SVneo under hyperglycemic condition.
Hyperglycemia
Kynurenine-Induced Aryl Hydrocarbon Receptor Signaling in Mice Causes Body Mass Gain, Liver Steatosis, and Hyperglycemia.
Hyperglycemia
Pharmacological regulation of cytochrome P450 metabolites of arachidonic acid attenuates cardiac injury in diabetic rats.
Hyperglycemia
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.
Hyperglycemia
The antidiabetic and hepatoprotective effects of magnolol on diabetic rats induced by high-fat diet and streptozotocin.
Hyperglycemia
The effects of diabetes with hyperlipidemia on P450 expression in APA hamster livers.
Hyperhomocysteinemia
Cytochrome P450 (CYP) 2J2 gene transfection attenuates MMP-9 via inhibition of NF-kappabeta in hyperhomocysteinemia.
Hyperhomocysteinemia
Echinocystic acid ameliorates hyperhomocysteinemia-induced vascular endothelial cell injury through regulating NF-?B and CYP1A1.
Hyperinsulinism
Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis.
Hyperinsulinism
Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.
Hyperinsulinism
Differential hepatic gene expression in a polygenic mouse model with insulin resistance and hyperglycemia: evidence for a combined transcriptional dysregulation of gluconeogenesis and fatty acid synthesis.
Hyperinsulinism
Effect of hyperinsulinemia and type 2 diabetes-like hyperglycemia on expression of hepatic cytochrome p450 and glutathione s-transferase isoforms in a New Zealand obese-derived mouse backcross population.
Hyperinsulinism
Hyperinsulinemia shifted energy supply from glucose to ketone bodies in early nonalcoholic steatohepatitis from high-fat high-sucrose diet induced Bama minipigs.
Hyperinsulinism
Insulin-lowering treatment reduces aromatase activity in response to follicle-stimulating hormone in women with polycystic ovary syndrome.
Hyperlipidemias
A study to evaluate herb-drug interaction underlying mechanisms: An investigation of ginsenosides attenuating the effect of warfarin on cardiovascular diseases.
Hyperlipidemias
Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status.
Hyperlipidemias
Cyclosporine-induced changes in drug metabolizing enzymes in hyperlipemic rabbit kidneys could explain its toxicity.
Hyperlipidemias
CYP2C9 Genetic Polymorphism is a Potential Predictive Marker for the Efficacy of Rosuvastatin Therapy.
Hyperlipidemias
Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance.
Hyperlipidemias
Effect of a high-calorie diet and constant light exposure on female reproduction, metabolism and immune inflammation: A comparative study of different mouse models.
Hyperlipidemias
Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes.
Hyperlipidemias
GENERATION OF HUMAN CHIRAL METABOLITES OF SIMVASTATIN AND LOVASTATIN BY BACTERIAL CYP102A1 MUTANTS.
Hyperlipidemias
Higher chlorzoxazone clearance in obese children compared with nonobese peers.
Hyperlipidemias
Hyperlipidemia exacerbates cerebral injury through oxidative stress, inflammation and neuronal apoptosis in MCAO/reperfusion rats.
Hyperlipidemias
Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk.
Hyperlipidemias
Linderae Radix Ethanol Extract Alleviates Diet-Induced Hyperlipidemia by Regulating Bile Acid Metabolism Through gut Microbiota.
Hyperlipidemias
Pharmacokinetics of a cytochrome P450 2E1 probe, chlorzoxazone, and its 6-hydroxy metabolite in poloxamer 407-induced hyperlipidemic rats.
Hyperlipidemias
The antidiabetic and hepatoprotective effects of magnolol on diabetic rats induced by high-fat diet and streptozotocin.
Hyperlipidemias
The effects of diabetes with hyperlipidemia on P450 expression in APA hamster livers.
Hyperlipoproteinemia Type II
Effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor pravastatin on urinary 6 beta-hydroxycortisol excretion: a preliminary study.
Hyperlipoproteinemia Type II
Genes Potentially Associated with Familial Hypercholesterolemia.
Hyperlipoproteinemia Type II
Late response to rosuvastatin and statin-related myalgia due to SLCO1B1, SLCO1B3, ABCB11, and CYP3A5 variants in a patient with Familial Hypercholesterolemia: a case report.
Hyperoxaluria, Primary
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
Hyperparathyroidism
Iatrogenic vitamin D toxicity in an infant - a case report and review of literature.
Hyperparathyroidism
Skeletal toxicity resulting from exposure of growing male rats to coplanar PCB 126 is associated with disruption of calcium homeostasis and the GH-IGF-1 axis and direct effects on bone formation.
Hyperparathyroidism
Therapy-Resistant Hypercalcemia in a Patient with Inactivating CYP24A1 Mutation and Recurrent Nephrolithiasis: Beware of Concomitant Hyperparathyroidism.
Hyperparathyroidism, Primary
Gestational hypercalcemia: Prevalence and biochemical profile.
Hyperparathyroidism, Primary
Ketoconazole reduces elevated serum levels of 1,25-dihydroxyvitamin D in hypercalcemic sarcoidosis.
Hyperparathyroidism, Secondary
E-pharmacophore filtering and molecular dynamics simulation studies in the discovery of potent drug-like molecules for chronic kidney disease.
Hyperparathyroidism, Secondary
Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-?B signaling pathway in secondary hyperparathyroidism.
Hyperparathyroidism, Secondary
Recent developments for introducing a hexafluoroisopropanol unit into the Vitamin D side chain.
Hyperphosphatemia
FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF23 signaling and regulating FGF23 expression in bone.
Hyperprolactinemia
CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects.
Hyperprolactinemia
CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine.
Hyperprolactinemia
Effects of aripiprazole on circadian prolactin secretion related to pharmacogenetics in healthy volunteers.
Hyperprolactinemia
Hyperprolactinemia in Children and Adolescents with Use of Risperidone: Clinical and Molecular Genetics Aspects.
Hyperprolactinemia
Impact of the CYP2D6 phenotype on hyperprolactinemia development as an adverse event of treatment with atypical antipsychotic agents in pediatric patients.
Hyperprolactinemia
Stimulatory effects of hyperprolactinemia on aldosterone secretion in ovariectomized rats.
Hyperprolactinemia
The effect of CYP2D6 variation on antipsychotic-induced hyperprolactinaemia: a systematic review and meta-analysis.
Hypersensitivity
A case of hypercalcemia Indications for 1,25-dihydroxyvitamin D prescription.
Hypersensitivity
Application of a pharmacogenetic test adoption model to six oncology biomarkers.
Hypersensitivity
Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity.
Hypersensitivity
Association of CYP1B1 with hypersensitivity induced by Taxane therapy in breast cancer patients.
Hypersensitivity
Biallelic mutations in CYP24A1 or SLC34A1 as a cause of infantile idiopathic hypercalcemia (IIH) with vitamin D hypersensitivity: molecular study of 11 historical IIH cases.
Hypersensitivity
Calcium pyrophosphate deposition disease revealing a hypersensitivity to vitamin D.
Hypersensitivity
Cutaneous metabolic activation of carvoxime, a self-activating, skin-sensitizing prohapten.
Hypersensitivity
CYP2B6 c.983T>C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations.
Hypersensitivity
Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications.
Hypersensitivity
Differential effects of 2C9*3 and 2C9*2 variants of cytochrome P-450 CYP2C9 on sensitivity to acenocoumarol.
Hypersensitivity
DNA damage by 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced p53-mediated apoptosis through activation of cytochrome P450/aryl hydrocarbon receptor.
Hypersensitivity
Expression and inducibility of antigens in severe combined immunodeficient mice recognized by human anti-P450 antibodies.
Hypersensitivity
Genetic variants of drug metabolizing enzymes and drug transporter (ABCB1) as possible biomarkers for adverse drug reactions in an HIV/AIDS cohort in Zimbabwe.
Hypersensitivity
Hepatic Cytochrome P450 Activity and Nitric Oxide Production During Multiple Ovalbumin Challenges.
Hypersensitivity
HLA Alleles and CYP2C9*3 as Predictors of Phenytoin Hypersensitivity in East Asians.
Hypersensitivity
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Hypersensitivity
Human anti-cytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions.
Hypersensitivity
Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)
Hypersensitivity
In men with erectile dysfunction, satisfaction with quality of erections correlates with erection hardness, treatment satisfaction, and emotional well-being.
Hypersensitivity
In silico identification of coffee genome expressed sequences potentially associated with resistance to diseases.
Hypersensitivity
Increased risk of erythema multiforme major with combination anticonvulsant and radiation therapies.
Hypersensitivity
Molecular cloning and expression of a novel cytochrome p450 from Turkey liver with aflatoxin b(1) oxidizing activity.
Hypersensitivity
NMDA sensitization and stimulation by peroxynitrite, nitric oxide, and organic solvents as the mechanism of chemical sensitivity in multiple chemical sensitivity.
Hypersensitivity
Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions.
Hypersensitivity
Nonenzymatic formation of a novel hydroxylated sulfamethoxazole derivative in human liver microsomes: implications for bioanalysis of sulfamethoxazole metabolites.
Hypersensitivity
Pharmacogenetic determinants of immediate and delayed reactions of drug hypersensitivity.
Hypersensitivity
Stable expression of human CYP2E1 in Chinese hamster cells: high sensitivity to N,N-dimethylnitrosamine in cytotoxicity testing.
Hypersensitivity
The Absence of CYP3A5*3 Is a Protective Factor to Anticonvulsants Hypersensitivity Reactions: A Case-Control Study in Brazilian Subjects.
Hypersensitivity
The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity.
Hypersensitivity
Topically injected adrenocorticotropic hormone induces mechanical hypersensitivity on a full-thickness cutaneous wound model in rats.
Hypersensitivity
Trichloroethylene-induced hypersensitivity dermatitis was associated with hepatic metabolic enzyme genes and immune-related genes.
Hypersensitivity
Unexpected acute pulmonary embolism in an old COVID-19 patient with warfarin overdose: a case report.
Hypersensitivity
[Identification of a novel CYP2C9 gene mutation (1400T>C) and assessment of its enzymatic activity in vitro].
Hypersensitivity
[Impact of pharmacogenetics on interindividual variability in the response to vitamin K antagonist therapy]
Hypersensitivity
[Relationship between gene polymorphism of CYP2E1, CYP1A1, IL-4 and medicamentosa-like der-matitis induced by trichloroethylene.]
Hypersensitivity
[Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs].
Hypertension
2,3',4,5'-TETRAMETHOXYSTILBENE PREVENTS DEOXYCORTICOSTERONE-SALT-INDUCED HYPERTENSION: CONTRIBUTION OF CYTOCHROME P4501B1.
Hypertension
2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Vascular Dysfunction That is Dependent on Perivascular Adipose and Cytochrome P4501A1 Expression.
Hypertension
2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice.
Hypertension
20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-?B Translocation and Promoter Binding.
Hypertension
20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease.
Hypertension
20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR.
Hypertension
20-Hydroxyeicosatetraenoic acid is not associated with circulating insulin in lean to overweight humans.
Hypertension
6?-hydroxytestosterone, a cytochrome P450 1B1 metabolite of testosterone, contributes to angiotensin II-induced hypertension and its pathogenesis in male mice.
Hypertension
6?-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone-Metabolite, Mediates Angiotensin II-Induced Renal Dysfunction in Male Mice.
Hypertension
6?-Hydroxytestosterone, a metabolite of testosterone generated by CYP1B1, contributes to vascular changes in angiotensin II-induced hypertension in male mice.
Hypertension
A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population.
Hypertension
A review of smoking cessation: potentially risky effects on prescribed medications.
Hypertension
A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese.
Hypertension
Abnormal pressure-natriuresis in hypertension: role of cytochrome P450 metabolites of arachidonic acid.
Hypertension
Activity of the Estrogen-Metabolizing Enzyme Cytochrome P450 1B1 Influences the Development of Pulmonary Arterial Hypertension.
Hypertension
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.
Hypertension
Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria.
Hypertension
Altered pharmacokinetics and excessive hypotensive effect of candesartan in a patient with the CYP2C91/3 genotype.
Hypertension
Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.
Hypertension
Angiotensin II-induced hypertension: contribution of Ras GTPase/Mitogen-activated protein kinase and cytochrome P450 metabolites.
Hypertension
Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease.
Hypertension
Arachidonic acid cytochrome P450 4F2 in hypertension: what can we learn from a transgenic mouse model??
Hypertension
Aripiprazole-induced atrial fibrillation in a patient with concomitant risk factors.
Hypertension
Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study.
Hypertension
Association Between CYP3A5 Polymorphisms and Blood Pressure in Kidney Transplant Recipients Receiving Calcineurin Inhibitors.
Hypertension
Association between daily cigarette consumption and hypertension moderated by CYP2A6 genotypes in Chinese male current smokers.
Hypertension
Association between hypertension and coffee drinking based on CYP1A2 rs762551 single nucleotide polymorphism in Taiwanese.
Hypertension
Association of coffee consumption and CYP1A2 polymorphism with risk of impaired fasting glucose in hypertensive patients.
Hypertension
Association of CYP2D6 and ADRB1 genes with hypotensive and antichronotropic action of betaxolol in patients with arterial hypertension.
Hypertension
Association of CYP3A5 Gene Polymorphisms and Amlodipine-Induced Peripheral Edema in Chinese Han Patients with Essential Hypertension.
Hypertension
Association of CYP3A5 polymorphisms with hypertension and antihypertensive response to verapamil.
Hypertension
Association of cytochrome P450 1B1 gene polymorphisms and environmental biomarkers with hypertension in Slovak midlife women.
Hypertension
Association of the CYP3A5 polymorphism (6986G>A) with blood pressure and hypertension.
Hypertension
Associations between ADRB1 and CYP2D6 gene polymorphisms and the response to ?-blocker therapy in hypertension.
Hypertension
Associations of genetic polymorphisms of the vitamin D pathway with blood pressure in a Han Chinese population.
Hypertension
Brain Testosterone-CYP1B1 (Cytochrome P450 1B1) Generated Metabolite 6?-Hydroxytestosterone Promotes Neurogenic Hypertension and Inflammation.
Hypertension
Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension.
Hypertension
Central CYP1B1 (Cytochrome P450 1B1)-Estradiol Metabolite 2-Methoxyestradiol Protects From Hypertension and Neuroinflammation in Female Mice.
Hypertension
Combined homozygous 21 hydroxylase with heterozygous P450 oxidoreductase mutation in a Saudi boy presented with hypertension.
Hypertension
Contribution of cytochrome P450 1B1 to hypertension and associated pathophysiology: A novel target for antihypertensive agents.
Hypertension
Contribution of cytochrome P450 metabolites of arachidonic acid to hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME.
Hypertension
Contribution of Ras GTPase/MAP kinase and cytochrome P450 metabolites to deoxycorticosterone-salt-induced hypertension.
Hypertension
Controlled hypertension, a transgenic toggle switch reveals differential mechanisms underlying vascular disease.
Hypertension
CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension.
Hypertension
CYP3A4 and CYP3A5 polymorphisms and blood pressure response to amlodipine among African-American men and women with early hypertensive renal disease.
Hypertension
CYP3A5 as a candidate gene for hypertension: no support from an unselected indigenous West African population.
Hypertension
CYP3A5 genotype is associated with diagnosis of hypertension in elderly patients: data from the DEBATE Study.
Hypertension
CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults.
Hypertension
CYP3A5 Genotype-Dependent Drug-Drug Interaction Between Tacrolimus and Nifedipine in Chinese Renal Transplant Patients.
Hypertension
CYP3A5 polymorphism and sensitivity of blood pressure to dietary salt in Japanese men.
Hypertension
Cytochrome P450 1A1 (CYP1A1) T6325C polymorphism might modulate essential hypertension-associated stroke risk.
Hypertension
Cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiology.
Hypertension
Cytochrome P450 1B1 contributes to increased blood pressure and cardiovascular and renal dysfunction in spontaneously hypertensive rats.
Hypertension
Cytochrome P450 1B1 contributes to renal dysfunction and damage caused by angiotensin II in mice.
Hypertension
Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice.
Hypertension
Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice.
Hypertension
Cytochrome P450 1B1 gene disruption minimizes deoxycorticosterone acetate-salt-induced hypertension and associated cardiac dysfunction and renal damage in mice.
Hypertension
Cytochrome P450 1B1 Is Critical for Neointimal Growth in Wire-Injured Carotid Artery of Male Mice.
Hypertension
Cytochrome P450 metabolites of arachidonic acid in the control of renal function.
Hypertension
Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system.
Hypertension
Cytochrome P4501A1 is required for vascular dysfunction and hypertension induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Hypertension
Decreased renal cytochrome P450 2C enzymes and impaired vasodilation are associated with angiotensin salt-sensitive hypertension.
Hypertension
Dexfenfluramine and the oestrogen metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension.
Hypertension
DISRUPTION OF THE CYTOCHROME P450 1B1 GENE EXACERBATES RENAL DYSFUNCTION AND DAMAGE ASSOCIATED WITH ANGIOTENSIN II-INDUCED HYPERTENSION IN FEMALE MICE.
Hypertension
Distributive characteristics of the CYP2C9 and AGTR1 genetic polymorphisms in Han Chinese hypertensive patients: a retrospective study.
Hypertension
Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes.
Hypertension
Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part II.
Hypertension
Effect of CYP3A51/3 polymorphism on blood pressure in renal transplant recipients.
Hypertension
Effect of marine collagen peptides on markers of metabolic nuclear receptors in type 2 diabetic patients with/without hypertension.
Hypertension
Effect of type 2 diabetes mellitus on the pharmacokinetics and transplacental transfer of nifedipine in hypertensive pregnant women.
Hypertension
Effects of Commonly Administered Agents and Genetics on Nebivolol Pharmacokinetics: Drug-Drug Interaction Studies.
Hypertension
Estrogen metabolism by cytochrome P450 1B1 modulates the hypertensive effect of angiotensin II in female mice.
Hypertension
Estrogen Signaling and Portopulmonary Hypertension: The Pulmonary Vascular Complications of Liver Disease Study (PVCLD2).
Hypertension
Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet.
Hypertension
First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia.
Hypertension
Functional characterization of CYP2C19 variants in nebivolol 4-hydroxlation in vitro.
Hypertension
Functional polymorphisms in the CYP3A4, CYP3A5, and CYP21A2 genes in the risk for hypertension in pregnancy.
Hypertension
Gene Delivery of a Cytochrome P450 Epoxygenase Ameliorates Monocrotaline-induced Pulmonary Artery Hypertension in Rats.
Hypertension
Gene-environment interactions of selected pharmacogenes in arterial hypertension.
Hypertension
Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats.
Hypertension
Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia.
Hypertension
Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition.
Hypertension
Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone.
Hypertension
Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy.
Hypertension
Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?
Hypertension
Hypertension-susceptibility gene prevalence in the Pacific Islands and associations with hypertension in Melanesia.
Hypertension
Identification of CYP1B1-specific candidate inhibitors using combination of in silico screening, integrated knowledge-based filtering, and molecular dynamics simulations.
Hypertension
Identification of Genetic Factors Underlying the Association between Sodium Intake Habits and Hypertension Risk.
Hypertension
IL6 suppression provides renal protection independent of blood pressure in a murine model of salt-sensitive hypertension.
Hypertension
Implications of cytochrome P450 interactions when prescribing medication for hypertension.
Hypertension
In vitro and in vivo drug-drug interaction of losartan and glimepiride in rats and its possible mechanism.
Hypertension
Incorporation of Gene-Environment Interaction Terms Improved the Predictive Accuracy of Tacrolimus Stable Dose Algorithms in Chinese Adult Renal Transplant Recipients.
Hypertension
Influence of CYP2D6 Polymorphism on the Pharmacokinetic/Pharmacodynamic Characteristics of Carvedilol in Healthy Korean Volunteers.
Hypertension
Influence of genetic polymorphisms of CYP3A5 and ABCB1 on sirolimus pharmacokinetics, patient and graft survival and other clinical outcomes in renal transplant.
Hypertension
Inhibition of renal outer medullary 20-HETE production produces hypertension in Lewis rats.
Hypertension
Interaction of drugs amlodipine and paroxetine with the metabolizing enzyme CYP2B4: a molecular dynamics simulation study.
Hypertension
Involvement of cytochrome P-450 1B1 in renal dysfunction, injury, and inflammation associated with angiotensin II-induced hypertension in rats.
Hypertension
Kidney dysfunction and hypertension: role for cadmium, p450 and heme oxygenases?
Hypertension
Lack of Pharmacokinetic Interactions Between Macitentan and a Combined Oral Contraceptive in Healthy Female Subjects.
Hypertension
Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases.
Hypertension
Machine learning algorithm-based risk prediction model of coronary artery disease.
Hypertension
Mutational analysis of CYP2C8 in hypertensive patients using denaturing high performance liquid chromatography.
Hypertension
No association of the CYP3A5*1 allele with blood pressure and left ventricular mass and geometry: the KORA/MONICA Augsburg echocardiographic substudy.
Hypertension
Nonesterified fatty acids in the pathogenesis of hypertension: theory and evidence.
Hypertension
Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide.
Hypertension
Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients - thinking of clinically relevant CYP2D6 interactions.
Hypertension
Pharmacokinetic interactions between indinavir plus ritonavir and calcium channel blockers.
Hypertension
Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Hypertension
Potential for early involvement of CYP isoforms in aspects of human cadmium toxicity.
Hypertension
Potential for pharmacokinetic interactions between ambrisentan and cyclosporine.
Hypertension
Potential role of CYP1B1 in the development and treatment of metabolic diseases.
Hypertension
Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking.
Hypertension
Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population.
Hypertension
Renal and hepatic accumulation of cadmium and lead in the expression of CYP4F2 and CYP2E1.
Hypertension
Renal cytochrome P4504A activity and salt sensitivity in spontaneously hypertensive rats.
Hypertension
Renal P450 metabolites of arachidonic acid and the development of hypertension in Dahl salt-sensitive rats.
Hypertension
Respiratory, cardiovascular and other physiological consequences of smoking cessation.
Hypertension
Revealing the contribution of Cytochrome P450 to salt-sensitive hypertension using DNA microarray.
Hypertension
Risk of tacrolimus toxicity in CYP3A5 nonexpressors treated with intravenous nicardipine after kidney transplantation.
Hypertension
Role of CYP450 in pharmacokinetics and pharmacogenetics of antihypertensive drugs.
Hypertension
Role of cytochrome P450 epoxygenase in regulating renal membrane transport and hypertension.
Hypertension
Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension.
Hypertension
Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.
Hypertension
Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension.
Hypertension
Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.
Hypertension
Testosterone Metabolite 6?-Hydroxytestosterone Contributes to Angiotensin II-Induced Abdominal Aortic Aneurysms in Apoe-/- Male Mice.
Hypertension
The absence of sympathoexcitation during the development of hypertension in Cyp1a1 Ren-2 transgenic rats.
Hypertension
The Association of ADRB1 and CYP2D6 Polymorphisms With Antihypertensive Effects and Analysis of Their Contribution to Hypertension Risk.
Hypertension
The CYP P450 arachidonic acid monooxygenases: from cell signaling to blood pressure regulation.
Hypertension
The endothelin receptor antagonist macitentan for the treatment of pulmonary arterial hypertension: A cross-species comparison of its cytochrome P450 induction pattern.
Hypertension
The inflammatory aspect of the microcirculation in hypertension: oxidative stress, leukocytes/endothelial interaction, apoptosis.
Hypertension
The Prevalence of CYP2C8, 2C9, 2J2, and soluble epoxide hydrolase polymorphisms in African Americans with hypertension.
Hypertension
The role of cytochrome P450 gene rs1126742 polymorphism and risk of hypertension: a systematic review and meta-analysis.
Hypertension
Three Sisters With Heterozygous Gene Variants of CYP24A1: Maternal Hypercalcemia, New-Onset Hypertension, and Neonatal Hypoglycemia.
Hypertension
Understanding the genetic basis for adverse drug effects: the calcineurin inhibitors.
Hypertension
Urinary 20-hydroxyeicosatetraenoic acid is associated with endothelial dysfunction in humans.
Hypertension
Vascular contributions to cognitive impairment and dementia: the emerging role of 20-HETE.
Hypertension
Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension.
Hypertension
Warfarin Anticoagulation Therapy in Caribbean Hispanics of Puerto Rico: A Candidate Gene Association Study.
Hypertension
[Association between cytochrome p4502c9 polymorphisms and losartan dosing in hypertensive patients].
Hypertension
[Efficacy and safety of bisoprolol in pregnant women with chronic arterial hypertension do not depend on genetic CYP2D6 polymorphism]
Hypertension
[Genetic aspects of individual sensitivity to betaxolol in patients with arterial hypertension]
Hypertension, Malignant
20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats.
Hypertension, Malignant
Fenofibrate Attenuates Malignant Hypertension by Suppression of the Renin-angiotensin System: A Study in Cyp1a1-Ren-2 Transgenic Rats.
Hypertension, Portal
Arachidonic acid metabolites and endothelial dysfunction of portal hypertension.
Hypertension, Portal
Inhibition of P-glycoprotein, multidrug resistance-associated protein 2 and cytochrome P450 3A4 improves the oral absorption of octreotide in rats with portal hypertension.
Hypertension, Pregnancy-Induced
A polymorphism in the CYP17 gene and intrauterine fetal growth restriction.
Hypertension, Pregnancy-Induced
Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension.
Hypertension, Pulmonary
20-HETE-Induced Mitochondrial Superoxide and Inflammatory Phenotype in Vascular Smooth Muscle is Prevented by Glucose-6-Phosphate Dehydrogenase Inhibition.
Hypertension, Pulmonary
Assessment of the effects of renal impairment and smoking on the pharmacokinetics of a single oral dose of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521).
Hypertension, Pulmonary
Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling.
Hypertension, Pulmonary
Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension.
Hypertension, Pulmonary
Effect of monocrotaline metabolites on glutathione levels in human and bovine pulmonary artery endothelial cells.
Hypertension, Pulmonary
Functional characterization of 27 CYP3A4 variants on macitentan metabolism in vitro.
Hypertension, Pulmonary
Gene Delivery of a Cytochrome P450 Epoxygenase Ameliorates Monocrotaline-induced Pulmonary Artery Hypertension in Rats.
Hypertension, Pulmonary
Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension.
Hypertension, Pulmonary
Oestradiol metabolism and androgen receptor genotypes are associated with right ventricular function.
Hypertension, Pulmonary
Pharmacokinetic interaction of riociguat with ketoconazole, clarithromycin, and midazolam.
Hypertension, Pulmonary
The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1.
Hypertension, Pulmonary
Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities.
Hypertension, Pulmonary
[Relationship between the converting ability of liver microsomes and monocrotaline-induced pulmonary hypertension in male, female and castrated male rats]
Hypertension, Renovascular
Fenofibrate Attenuates Hypertension in Goldblatt Hypertensive Rats: Role of 20-Hydroxyeicosatetraenoic Acid in the Nonclipped Kidney.
Hyperthyroidism
Acute hyperthyroidism alters adrenoceptor- and muscarinic receptor-mediated responses in isolated rat renal and femoral arteries.
Hyperthyroidism
Analysis of differentially expressed genes in hyperthyroid-induced hypertrophied heart by cDNA microarray.
Hyperthyroidism
Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity.
Hyperthyroidism
Effects of methimazole on Drosophila glucolipid metabolism in vitro and in vivo.
Hyperthyroidism
Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: A targeted metabolomic approach.
Hyperthyroidism
Enhancement of lindane-induced liver oxidative stress and hepatotoxicity by thyroid hormone is reduced by gadolinium chloride.
Hyperthyroidism
MATERNAL GRAVES DISEASE AND ABNORMAL CYP2D6 GENOTYPE WITH FETAL HYPERTHYROIDISM.
Hyperthyroidism
Role of thyroid state on induction by ciprofibrate of laurate hydroxylase and peroxisomal enzymes in rat liver microsomes.
Hypertrophy, Left Ventricular
Left Ventricular Hypertrophy: Roles of Mitochondria CYP1B1 and Melatonergic Pathways in Co-Ordinating Wider Pathophysiology.
Hypertrophy, Left Ventricular
The CYP2C9 genotype predicts the blood pressure response to irbesartan: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA) trial.
Hypoalbuminemia
Effect of hypoalbuminemia on the disposition of theophylline. Comparative study with Sprague-Dawley rats and a mutant Sprague-Dawley hyperlipidemic strain with hypoalbuminemia.
Hypoalbuminemia
Revalidation of CoaguChek XS plus system for INR monitoring in Taiwanese patients: effects of clinical and genetic factors.
Hypoglycemia
Association Between the CYP2C9 Genotype and Hypoglycemia Among Patients With Type 2 Diabetes Receiving Sulfonylurea Treatment: A Meta-analysis.
Hypoglycemia
Association of KCNJ11 E23K gene polymorphism with hypoglycemia in sulfonylurea-treated Type 2 diabetic patients.
Hypoglycemia
Hypoglycemia and Glycemic Control With Glyburide in Women With Gestational Diabetes and Genetic Variants of Cytochrome P450 2C9 and/or OATP1B3.
Hypoglycemia
Impact of clinical factors and CYP2C9 variants for the risk of severe sulfonylurea-induced hypoglycemia.
Hypoglycemia
Pharmacoepidemiologic and in Vitro Evaluation of Potential Drug-Drug Interactions of Sulfonylureas with Fibrates and Statins.
Hypoglycemia
Pharmacogenetics of hypoglycemia associated with sulfonylurea therapy in usual clinical care.
Hypoglycemia
Presence of CYP2C9*3 allele increases risk for hypoglycemia in Type 2 diabetic patients treated with sulfonylureas.
Hypoglycemia
TCF7L2 rs7903146 C>T gene polymorphism is not associated with hypoglycemia in sulfonylurea-treated type 2 diabetic patients.
Hypoglycemia
The CYP2C9 polymorphism: from enzyme kinetics to clinical dose recommendations.
Hypoglycemia
The Genetics of Adverse Drug Outcomes in Type 2 Diabetes: A Systematic Review.
Hypoglycemia
Three Sisters With Heterozygous Gene Variants of CYP24A1: Maternal Hypercalcemia, New-Onset Hypertension, and Neonatal Hypoglycemia.
Hypoglycemia
[Status of the monooxygenase enzyme system in rat and rabbit organs in sugar diabetes and upon insulin administration]
Hypogonadism
Aromatase deficiency in a female who is compound heterozygote for two new point mutations in the P450arom gene: impact of estrogens on hypergonadotropic hypogonadism, multicystic ovaries, and bone densitometry in childhood.
Hypogonadism
Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction.
Hypogonadism
Correlation between serum P450arom and sex hormones in males with late-onset hypogonadism: a pilot study.
Hypogonadism
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
Hypokalemia
Quetiapine, QTc interval prolongation, and torsade de pointes: a review of case reports.
Hypokalemia
Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.
Hypokalemia
Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.
Hypokinesia
[The state of the monooxygenase enzymatic system of the rat liver in hypokinesia]
Hypophosphatemia, Familial
Transcriptional and physiological responses to chronic ACTH treatment by the mouse kidney.
Hypospadias
Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadias.
Hypospadias
Delayed diagnosis of adrenal insufficiency in a patient with severe penoscrotal hypospadias due to two novel P450 side-change cleavage enzyme (CYP11A1) mutations (p.R360W; p.R405X).
Hypospadias
Exploiting gene-environment interaction to detect adverse health effects of environmental chemicals on the next generation.
Hypospadias
Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter.
Hypospadias
Maternal genetic polymorphisms in CYP1A1, GSTM1 and GSTT1 and the risk of hypospadias.
Hypospadias
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
Hypospadias
Polymorphism in CYP1A1, GSTM 1, GSTT1 genes and organochlorine pesticides in the etiology of hypospadias.
Hypospadias
Polymorphisms in the P450 c17 (17-Hydroxylase/17, 20-Lyase) Gene: Association with Estradiol and Testosterone Concentration in Hypospadias.
Hypotension
5,6-?-DHTL, a stable metabolite of arachidonic acid, is a potential substrate for paraoxonase 1.
Hypotension
Co-prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study.
Hypotension
Combining Antidepressants with ?-Blockers: Evidence of a Clinically Significant CYP2D6 Drug Interaction.
Hypotension
Effect of potassium channel and cytochrome P450 inhibition on transient hypotension and survival during lipopolysaccharide-induced endotoxic shock in the rat.
Hypotension
Inhibition by nitric oxide of cytochrome P450 4A activity contributes to endotoxin-induced hypotension in rats.
Hypotension
Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide.
Hypotension
Paraoxonase 1 in endothelial cells impairs vasodilation induced by arachidonic acid lactone metabolite.
Hypotension
Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production.
Hypotension
[Clinical survey of tizanidine-induced adverse effects--impact of concomitant drugs providing cytochrome P450 1A2 modification--].
Hypotension
[Psychopharmacological treatment of patients complicated with cardiovascular disease].
Hypothyroidism
Effect of thyroid hormone status and concomitant medication on statin induced adverse effects in hyperlipidemic patients.
Hypothyroidism
Hepatic P450 expression in hypothyroid rats: differential responsiveness of male-specific P450 forms 2a (IIIA2), 2c (IIC11), and RLM2 (IIA2) to thyroid hormone.
Hypothyroidism
Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase.
Hypothyroidism
Role of thyroid state on induction by ciprofibrate of laurate hydroxylase and peroxisomal enzymes in rat liver microsomes.
Hypothyroidism
THE EFFECTS OF MATERNAL HYPOTHYROIDISM ON THE IMMUNOREACTIVITY OF CYTOCHROME P450 AROMATASE IN THE POSTNATAL RAT TESTICLES.
Hypoxia-Ischemia, Brain
Effect of Hypothermia and Targeted Temperature Management on Drug Disposition and Response Following Cardiac Arrest: A Comprehensive Review of Preclinical and Clinical Investigations.
Ichthyosis, Lamellar
Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3.
Ileus
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Infarction, Middle Cerebral Artery
Cytochrome P450 CYP2E1 Suppression Ameliorates Cerebral Ischemia Reperfusion Injury.
Infarction, Middle Cerebral Artery
Hyperbaric oxygenation and 20-HETE inhibition reduce stroke volume in female diabetic Sprague-Dawley rats.
Infarction, Middle Cerebral Artery
Reduction of thyroid hormones triggers down-regulation of hepatic CYP2B through nuclear receptors CAR and TR in a rat model of acute stroke.
Infarction, Middle Cerebral Artery
Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium.
Infarction, Middle Cerebral Artery
Soluble epoxide hydrolase: a novel therapeutic target in stroke.
Infections
A comparison of available and investigational antibiotics for complicated skin infections and treatment-resistant Staphylococcus aureus and enterococcus.
Infections
A new approach to cytochrome CYP2D6 antibody detection in autoimmune hepatitis type-2 (AIH-2) and chronic hepatitis C virus (HCV) infection: a sensitive and quantitative radioligand assay.
Infections
A study of hepatic mitochondrial respiration and microsomal cytochrome P450 content in mice infected with the liver fluke Fasciola hepatica.
Infections
A virus-directed enzyme prodrug therapy (VDEPT) strategy for lung cancer using a CYP2B6/NADPH-cytochrome P450 reductase fusion protein.
Infections
Absence of CYP2B6 promoter -82T>C mutation in Chinese as an additional factor for slow metabolism of drugs commonly used in infections.
Infections
Activation of promutagens in a human bronchial epithelial cell line stably expressing human cytochrome P450 1A2.
Infections
Activity of liver microsomal enzymes during the chronic phase of murine schistosomiasis.
Infections
Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1.
Infections
Ah receptor and NF-kappaB interactions: mechanisms and physiological implications.
Infections
Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: implications for impaired immune function during disease.
Infections
Alteration of drug biotransformation and elimination during infection and inflammation.
Infections
Altered decidual and placental catabolism of vitamin D may contribute to the aetiology of spontaneous miscarriage.
Infections
An integrated in vitro model for simultaneous assessment of drug uptake, metabolism, and efflux.
Infections
Antihepatotoxic properties of uridine-diphosphoglucose in liver fluke infection. Experimental fascioliasis in the rat.
Infections
Antitrypanosomal Activity of Sterol 14?-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain.
Infections
Aryl hydrocarbon receptor is required for immune response in Epinephelus coioides and Danio rerio infected by Pseudomonas plecoglossicida.
Infections
Association of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana.
Infections
Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease.
Infections
Baculovirus expression of human P450 2E1 and cytochrome b5: spectral and catalytic properties and effect of b5 on the stoichiometry of P450 2E1-catalyzed reactions.
Infections
Basis for the loss of aryl hydrocarbon receptor gene expression in clones of a mouse hepatoma cell line.
Infections
Biochemical properties of the products of cytochrome P450 genes (PDA) encoding pisatin demethylase activity in nectria haematococca
Infections
Broad but distinct role of pregnane x receptor on the expression of individual cytochrome p450s in human hepatocytes.
Infections
Catalytic characterization and cytokine mediated regulation of cytochrome P450 4Fs in rat hepatocytes.
Infections
Changes in the expression of cytochrome P450 isozymes and related carcinogen metabolizing enzyme activities in Schistosoma mansoni-infected mice.
Infections
Characterization of the mouse olfactory glutathione S-transferases during the acute phase response.
Infections
Clinical pharmacology profile of boceprevir, a hepatitis C virus NS3 protease inhibitor: focus on drug-drug interactions.
Infections
Co-expression of human cytochrome P4501A1 (CYP1A1) variants and human NADPH-cytochrome P450 reductase in the baculovirus/insect cell system.
Infections
Coexpression of cytochrome P4502A6 and human NADPH-P450 oxidoreductase in the baculovirus system.
Infections
Coxsackievirus B3 infection and PBDE exposure causes organ-specific effects on CYP-gene expression in the mouse.
Infections
Cyclophosphamide treatment-induced leukopenia rates in ANCA-associated vasculitis are influenced by variant CYP450 2C9 genotypes.
Infections
CYP1A1 mediates the suppression of major inflammatory cytokines in pulmonary alveolar macrophage (PAM) cell lines caused by Mycoplasma hyponeumoniae.
Infections
CYP1A1 Relieves Lipopolysaccharide-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells.
Infections
CYP24A1 genetic variants in the vitamin D metabolic pathway are involved in the outcomes of hepatitis C virus infection among high-risk Chinese population.
Infections
CYP27A1 inhibits bladder cancer cells proliferation by regulating cholesterol homeostasis.
Infections
CYP2D6 and CYP3A4 variants influence the risk and outcome of COVID-19 infection among rheumatoid arthritis patients maintained on hydroxychloroquine.
Infections
CYP2E1 genetic polymorphism with dietary, tobacco, alcohol habits, H. pylori infection status and susceptibility to stomach cancer in Mizoram, India.
Infections
CYPome of the conifer pathogen Heterobasidion irregulare: Inventory, phylogeny, and transcriptional analysis of the response to biocontrol.
Infections
Cytochrome P450 (CYP2D6) Genotype is Associated with Elevated Systolic Blood Pressure in Preterm Infants after Discharge from the Neonatal Intensive Care Unit.
Infections
Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in reactive arthritis.
Infections
Cytochrome P450 4F subfamily: at the crossroads of eicosanoid and drug metabolism.
Infections
Cytochrome P450 CYP2B6*6 distribution among Congolese individuals with HIV, Tuberculosis and Malaria infection.
Infections
Cytochrome P450 Genes (CYP2E1 and CYP1A1) Variants and Susceptibility to Chronic Hepatitis B Virus Infection.
Infections
Cytochrome P450 isoforms. Regulation during infection, inflammation and by cytokines.
Infections
Cytochrome P450 Monooxygenases CYP6AY3 and CYP6CW1 Regulate Rice Black-Streaked Dwarf Virus Replication in Laodelphax striatellus (Fallén).
Infections
Cytochrome P450 regulation and drug biotransformation during inflammation and infection.
Infections
Decrease in brain cytochrome P450 enzyme activities during infection and inflammation of the central nervous system.
Infections
Decreased tacrolimus plasma concentrations during HCV therapy: a drug-drug interaction or is there an alternative explanation?
Infections
Detection of auto-antibodies against cytochrome P4502E1 (CYP2E1) in chronic hepatitis C.
Infections
Development of human cytochrome P450-expressing cell lines: application in mutagenicity testing of ochratoxin A.
Infections
Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection.
Infections
Different levels of Schistosoma mansoni infection increased the mutagenicity of benzo(a)pyrene, the activity of aryl hydrocarbon hydroxylase and the formation of hepatic microsomal hydrogen peroxide.
Infections
Different levels of Schistosoma mansoni infection induce changes in drug-metabolizing enzymes.
Infections
Differential effects of recombinant interferon alpha on constitutive and inducible cytochrome P450 isozymes in mouse liver.
Infections
Disseminated mycobacterium avium-intracellulare complex (MAC) infection in the era of effective antiretroviral therapy: is prophylaxis still indicated?
Infections
Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients?
Infections
Down-regulation of phenobarbital-induced cytochrome P4502B mRNAs and proteins by endotoxin in mice: independence from nitric oxide production by inducible nitric oxide synthase.
Infections
Down-regulation of the hepatic cytochrome P450 by an acute inflammatory reaction: implication of mediators in human and animal serum and in the liver.
Infections
Effect of CYP2B6 Gene Polymorphisms on Efavirenz Plasma Concentrations in Chinese Patients with HIV Infection.
Infections
Effect of CYP2C19 and MDR1 polymorphisms on cure rate in patients with acid-related disorders with Helicobacter pylori infection.
Infections
Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.
Infections
Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes.
Infections
Effect of Pharmacogenetics Variations on Praziquantel Plasma Concentrations and Schistosomiasis Treatment Outcomes Among Infected School-Aged Children in Tanzania.
Infections
Effect of rifampicin and clarithromycin on the CYP3A activity in patients with Mycobacterium avium complex.
Infections
Effect of Traumatic Brain Injury, Erythropoietin, and Anakinra on Hepatic Metabolizing Enzymes and Transporters in an Experimental Rat Model.
Infections
Effects of bacterial lipopolysaccharide on phenobarbital-induced CYP2B expression in mice.
Infections
Effects of coxsackievirus B3 infection on the acute-phase protein metallothionein and on cytochrome P-4501A1 involved in the detoxification processes of TCDD in the mouse.
Infections
Effects of CYP3A5 Polymorphisms on Efficacy and Safety of Tacrolimus Therapy in Patients with Idiopathic Membranous Nephropathy.
Infections
Effects of experimental dicrocoeliosis on oxidative drug metabolism in hamster liver.
Infections
Efficient complementary DNA directed expression of human fetal liver cytochrome P450 (CYP3A7) in insect cells using baculovirus.
Infections
Establishment of a novel radioligand assay using eukaryotically expressed cytochrome P4502D6 for the measurement of liver kidney microsomal type 1 antibody in patients with autoimmune hepatitis and hepatitis C virus infection.
Infections
Estrogen Metabolism-Associated CYP2D6 and IL6-174G/C Polymorphisms in Schistosoma haematobium Infection.
Infections
Ethanol-related cytotoxicity catalyzed by CYP2E1-dependent generation of reactive oxygen intermediates in transduced HepG2 cells.
Infections
Evaluation of Luminogenic Substrates as Probe Substrates for Bacterial Cytochrome P450 Enzymes: Application to Mycobacterium tuberculosis.
Infections
Expanding the canon: Non-classical mosquito genes at the interface of arboviral infection.
Infections
Exposure to sublethal doses of fipronil and thiacloprid highly increases mortality of honeybees previously infected by Nosema ceranae.
Infections
Expression of cytochromes P450 4F4 and 4F5 in infection and injury models of inflammation.
Infections
EXPRESSION OF UDP-GLUCURONOSYLTRANSFERASE ISOFORM mRNAS DURING INFLAMMATION AND INFECTION IN MOUSE LIVER AND KIDNEY.
Infections
Factors involved in the down-regulation of cytochrome P450 during Listeria monocytogenes infection.
Infections
Field studies of aflatoxin exposure, metabolism and induction of genetic alterations in relation to HBV infection and hepatocellular carcinoma in The Gambia and Thailand.
Infections
Fungal Lanosterol 14?-demethylase: A target for next-generation antifungal design.
Infections
Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes.
Infections
Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection.
Infections
Genetic polymorphisms of the cancer related gene and Helicobacter pylori infection in Japanese gastric cancer patients. An age and gender matched case-control study.
Infections
Genome and transcriptome analysis of the latent pathogen Lasiodiplodia theobromae, an emerging threat to the cacao industry.
Infections
Genome-Wide Identification and Analysis of Chitinase GH18 Gene Family in Mycogone perniciosa.
Infections
Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: associations with tumor progression, age and human papillomavirus infection.
Infections
Glutathione Transferase and Cytochrome P450 (General Oxidase) Activity Levels in Candidatus Liberibacter Asiaticus-Infected and Uninfected Asian Citrus Psyllid (Hemiptera: Psyllidae)
Infections
Gut Transcription in Helicoverpa zea is Dynamically Altered in Response to Baculovirus Infection.
Infections
HBV/HCV Infection, Alcohol, Tobacco and Genetic Polymorphisms for Hepatocellular Carcinoma in Nagoya, Japan.
Infections
Helicobacter pylori infection, but not genetic polymorphism of CYP2E1, is highly prevalent in gastric cancer patients younger than 40 years.
Infections
Hepatic and renal cytochrome p450 gene regulation during citrobacter rodentium infection in wild-type and toll-like receptor 4 mutant mice.
Infections
Hepatic cytochrome P450 and related drug biotransformation during an outbreak of mouse hepatitis virus in a colony of Swiss BALB/c mice.
Infections
Hepatic microsomal cytochrome P450 system during experimental hookworm infection.
Infections
Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China.
Infections
Herbal extracts used for upper respiratory tract infections: are there clinically relevant interactions with the cytochrome P450 enzyme system?
Infections
Heterogeneity of liver/kidney microsomal antibody type 1 in autoimmune hepatitis and hepatitis C virus related liver disease.
Infections
High Plasma Efavirenz Concentration and CYP2B6 Polymorphisms in Thai HIV-1 Infections.
Infections
Human CYP1A1 allelic variants: baculovirus expression and purification, hydrodynamic, spectral, and catalytical properties and their potency in the formation of all-trans-retinoic acid.
Infections
Iatrogenic hypercortisolism complicating triamcinolone acetonide injections in patients with HIV on ritonavir-boosted protease inhibitors.
Infections
Identification and expression profile of the soil moisture and Ralstonia solanacearum response CYPome in ginger (Zingiber officinale).
Infections
Identification of Differentially Expressed Proteins in Sugarcane in Response to Infection by Xanthomonas albilineans Using iTRAQ Quantitative Proteomics.
Infections
Identification of Genes Expressed Differentially in Grapefruit Infected with Candidatus Liberibacter asiaticus in the Late Stage of Disease
Infections
Immune response following liver transplantation compared to kidney transplantation: usefulness of monitoring peripheral blood CD4+ adenosine triphosphate activity and cytochrome P450 3A5 genotype assay.
Infections
Impact of CYP2R1, CYP27A1 and CYP27B1 genetic polymorphisms controlling vitamin D metabolism on susceptibility to hepatitis C virus infection in a high-risk Chinese population.
Infections
In planta transcriptome analysis reveals tissue-specific expression of pathogenicity genes and microRNAs during rice-Magnaporthe interactions.
Infections
In Planta Variation of Volatile Biosynthesis: An Alternative Biosynthetic Route to the Formation of the Pathogen-Induced Volatile Homoterpene DMNT via Triterpene Degradation in Arabidopsis Roots.
Infections
In Vitro Susceptibility Testing of Bedaquiline against Mycobacterium avium Complex.
Infections
Individuals having variant genotypes of cytochrome P450 2C19 are at increased risk of developing primary liver cancer in Han populations, without infection with the hepatitis virus.
Infections
Induction of cytochrome P450 2A6 expression in humans by the carcinogenic parasite infection, opisthorchiasis viverrini.
Infections
Infection of rats with Taenia taeniformis metacestodes increases hepatic CYP450, induces the activity of CYP1A1, CYP2B1 and COH isoforms and increases the genotoxicity of the procarcinogens benzo[a]pyrene, cyclophosphamide and aflatoxin B(1).
Infections
Influence of chronic hepatitis C infection on cytochrome P450 3a4 activity using midazolam as an in vivo probe substrate.
Infections
Influence of Mycoplasma arginini infection on the induction of aryl hydrocarbon hydroxylase by TCDD in rat hepatoma cell cultures.
Infections
Influencing Factors for Cure of Clonorchiasis by Praziquantel Therapy: Infection Burden and CYP3A5 Gene Polymorphism.
Infections
Integrin Receptors Play a Key Role in the Regulation of Hepatic Cytochrome P450 3A.
Infections
Key residues of a major cytochrome P4502D6 epitope are located on the surface of the molecule.
Infections
Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners.
Infections
Listeriosis downregulates hepatic cytochrome P450 enzymes in sublethal murine infection.
Infections
Liver glutathione and cytochrome P450 activity in experimental infection: study of the relative effects of infectious stress and malnutrition.
Infections
Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection.
Infections
Liver receptor homolog-1 stimulates the progesterone biosynthetic pathway during follicle-stimulating hormone-induced granulosa cell differentiation.
Infections
Long-term clinical safety of Clindamycin and Rifampicin combination for the treatment of Hidradenitis suppurativa: a critically appraised topic.
Infections
Long-term enhancement of cytochrome P450 2B1/2 expression in rat hepatocyte spheroids through adenovirus-mediated gene transfer.
Infections
Mechanism of hepatic cytochrome P450 modulation during Listeria monocytogenes infection in mice.
Infections
Mechanism of impairment of cytochrome P450-dependent metabolism in hamster liver during leishmaniasis.
Infections
Medication use and medical comorbidity in patients with chronic hepatitis C from a US commercial claims database: high utilization of drugs with interaction potential.
Infections
Modulation of expression and activity of cytochrome P450s and alteration of praziquantel kinetics during murine schistosomiasis.
Infections
Modulation of hepatic cytochrome P450 during Listeria monocytogenes infection of the brain.
Infections
Modulation of hepatic cytochrome P450s by citrobacter rodentium infection in interleukin-6- and interferon-{gamma}-null mice.
Infections
Molecular Characterization and Functional Analysis of Three Pathogenesis-Related Cytochrome P450 Genes from Bursaphelenchus xylophilus (Tylenchida: Aphelenchoidoidea).
Infections
Mouse Forkhead L2 (FOXL2) maintains repression of FSH-dependent genes in the granulosa cell.
Infections
Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation.
Infections
Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli.
Infections
No Clinical Impact of CYP3A5 Gene Polymorphisms on the Pharmacokinetics and/or Efficacy of Maraviroc in Healthy Volunteers and HIV-1-Infected Subjects.
Infections
Ombitasvir/Paritaprevir/Ritonavir Plus Dasabuvir: A Review in Chronic HCV Genotype 1 Infection.
Infections
Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus.
Infections
Overexpression of CYP2E1 enhances sensitivity of hepG2 cells to fas-mediated cytotoxicity.
Infections
PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding.
Infections
Pharmacogenetic associations with cytochrome P450 in antiretroviral therapy: what does the future hold?
Infections
Pharmacogenetic Markers of CYP2B6 Associated with Efavirenz Plasma Concentrations in HIV-1 infected Thai Adults.
Infections
Pharmacokinetics/pharmacodynamics of chloroquine and artemisinin-based combination therapy with primaquine.
Infections
Plasmodium berghei (ANKA): infection induces CYP2A5 and 2E1 while depressing other CYP isoforms in the mouse liver.
Infections
Polymorphism of CYPIA1 and GSTM1 genes associated with susceptibility of gastric cancer in Shandong Province of China.
Infections
Polymorphisms and haplotypes of TLR4, TLR9 and CYP1A1 genes possibly interfere with high-risk human papillomavirus infection and cervical cancer susceptibility in Jharkhand, India.
Infections
Polymorphisms and the pocketbook: the cost-effectiveness of cytochrome P450 2C19 genotyping in the eradication of Helicobacter pylori infection associated with duodenal ulcer.
Infections
Possible isozyme-specific effects of experimental malaria infection with Plasmodium berghei on cytochrome P450 activity in rat liver microsomes.
Infections
Prevalence of CYP2D6 Genotypes and Predicted Phenotypes in a Cohort of Cambodians at High Risk for Infections with Plasmodium vivax.
Infections
Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene.
Infections
Real time PCR detection of common CYP2D6 genetic variants and its application in a Karen population study.
Infections
Regulation of hepatic cytochrome P450 expression in mice with intestinal or systemic infections of citrobacter rodentium.
Infections
Regulation of NAD(P)H:quinone oxidoreductase 1 gene expression by CYP1A1 activity.
Infections
Regulation of the CYP1A1 gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin but not by beta-naphthoflavone or 3-methylcholanthrene is altered in hepatitis C virus replicon-expressing cells.
Infections
Repression of Hepatic Cytochrome P450 2D Expression in Mice during Babesia microti Infection.
Infections
Response of the ileum transcriptome to fructo-oligosaccharides in Taiping chickens.
Infections
Rhabdomyolysis in an HIV-Infected Patient on Anti-Retroviral Therapy Precipitated by High-Dose Pravastatin.
Infections
Ritonavir and Topical Ocular Corticosteroid Induced Cushing's Syndrome in an Adolescent with HIV-1 Infection.
Infections
Role of nitric oxide in the inhibition of cytochrome P450 in the liver of mice infected with Chlamydia trachomatis.
Infections
Role of the pepper cytochrome P450 gene CaCYP450A in defense responses against microbial pathogens.
Infections
Secondary metabolism pathway polymorphisms and plasma efavirenz concentrations in HIV-infected adults with CYP2B6 slow metabolizer genotypes.
Infections
Selective Modulation of Hepatic Cytochrome P450 and Flavin Monooxygenase 3 Expression during Citrobacter rodentium Infection in Severe Combined Immune-Deficient Mice.
Infections
Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen.
Infections
Sera of children with hepatitis C infection and anti-liver-kidney microsome-1 antibodies recognize different CYP2D6 epitopes than adults with LKM+/HCV+ sera.
Infections
Short communication: Vitamin D status and responses in dairy cows naturally infected with Mycobacterium avium ssp. paratuberculosis.
Infections
Short-term inhibitory effects of nitric oxide on cytochrome P450-mediated drug metabolism: time dependency and reversibility profiles in isolated perfused rat livers.
Infections
Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
Infections
Studies on drug metabolizing enzymes during arteether treatment of Plasmodium yoelii nigeriensis infected mice cerebral microvessels.
Infections
Suppression of cytochrome P450- and UDP glucuronosyl transferase-dependent enzyme activities by proinflammatory cytokines and possible role of nitric oxide in primary cultures of pig hepatocytes.
Infections
Temporal Transcription Profiling of Sweet Orange in Response to PthA4-Mediated Xanthomonas citri subsp. citri Infection.
Infections
The effect of ivermectin alone and in combination with cobicistat or elacridar in experimental Schistosoma mansoni infection in mice.
Infections
The Enhanced Immune Protection in Small Abalone Haliotis diversicolor Against a Secondary Infection With Vibrio harveyi.
Infections
The relative importance of Ah versus H-2 genotype on Trichinella resistance following exposure to 3-methylcholanthrene.
Infections
The role of cytokines in the depression of CYP1A activity using cultured astrocytes as an in vitro model of inflammation in the central nervous system.
Infections
The structure of Mycobacterium tuberculosis CYP125: Molecular basis for cholesterol binding in a P450 needed for host infection.
Infections
Time-dependent amplified pharmacokinetic and pharmacodynamic responses of rabeprazole in cytochrome P450 2C19 poor metabolizers.
Infections
TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease.
Infections
Tocilizumab: new drug. Rheumatoid arthritis: another 'mab', no therapeutic advantage.
Infections
Transcriptional regulation of the grape cytochrome P450 monooxygenase gene CYP736B expression in response to Xylella fastidiosa infection.
Infections
Transcriptional Responses of the Trichoplusia ni Midgut to Oral Infection by the Baculovirus Autographa californica Multiple Nucleopolyhedrovirus.
Infections
Transcriptomic responses of water buffalo liver to infection with the digenetic fluke Fasciola gigantica.
Infections
Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study.
Infections
Up- and down-modulation of liver cytochrome P450 activities and associated events in two murine malaria models.
Infections
Up-regulation of glutathione S-transferases alpha by interleukin 4 in human hepatocytes in primary culture.
Infections
Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver.
Infections
Viral infection induces different detoxification enzyme activities in insecticide-resistant and -susceptible brown planthopper Nilaparvata lugens strains.
Infections
Vitamin-D: An innate antiviral agent suppressing Hepatitis C virus in human hepatocytes.
Infections
Voriconazole metabolism is influenced by severe inflammation: a prospective study.
Infections
Xenobiotic-metabolizing enzymes in carp (Cyprinus carpio) liver, spleen, and head kidney following experimental Listeria monocytogenes infection.
Infections
[CYP2D6*1, CYP2D6*10 co-expressed with CYPOR in Bac-to-Bac expression system and activity determination].
Infections
[Non aromatic hydrocarbon receptor dependent regulatory mechanism of cytochrome P4501A1 and its role in infection and inflammation].
Infections
[Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced influenza-virus-associated encephalopathy]
Infertility
Association between single nucleotide polymorphism of the CYP19A1 and ESR2 genes and endometriosis.
Infertility
Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility.
Infertility
Association of FSH receptor and CYP19A1 gene variations with sterility and ovarian hyperstimulation syndrome.
Infertility
CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women.
Infertility
Cytochrome P-450 1B1 Leu432Val Polymorphism Does Not Show Association With Breast Cancer in Northern Iranian Women With a History of Infertility.
Infertility
Effect of Lepidium meyenii (maca) on testicular function of mice with chemically and physically induced subfertility.
Infertility
Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis.
Infertility
FSH receptor, KL1/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis.
Infertility
Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues.
Infertility
Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue.
Infertility
Genetic Polymorphism of CYP2D6 and Clomiphene Concentrations in Infertile Patients with Ovulatory Dysfunction Treated with Clomiphene Citrate.
Infertility
Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites.
Infertility
High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome.
Infertility
Interactions between urinary 4-tert-octylphenol levels and metabolism enzyme gene variants on idiopathic male infertility.
Infertility
Liver receptor homologue-1 and steroidogenic factor-1 expression in cultured granulosa cells from patients with endometriosis: A preliminary study.
Infertility
Scrambled and fried: Cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress.
Infertility
Smoking status modifies the relation between CYP1A1*2C gene polymorphism and idiopathic male infertility: the importance of gene-environment interaction analysis for genetic studies of the disease.
Infertility
[Diagnostic value of the detection of aromatase cytochrome P450 and CA125 for endometriosis]
Infertility, Female
Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues.
Infertility, Male
Association between 3801T>C polymorphism of CYP1A1 and idiopathic male infertility risk: a systematic review and meta-analysis.
Infertility, Male
Association between CYP1A1 rs4646903 T > C genetic variations and male infertility risk: A meta-analysis.
Infertility, Male
Association between CYP1A1 rs4646903 T > C genetic variations and male infertility risk: A meta-analysis: Erratum.
Infertility, Male
Association of CYP1A1*2A polymorphism with male infertility in Indian population.
Infertility, Male
Association of MTHFR, NFKB1, NFKBIA, DAZL and CYP1A1 gene polymorphisms with risk of idiopathic male infertility in a Han Chinese population.
Infertility, Male
Combined effects of urinary phytoestrogens metabolites and polymorphisms in metabolic enzyme gene on idiopathic male infertility.
Infertility, Male
Disturbed testicular expression of the estrogen-metabolizing enzymes CYP1A1 and COMT in infertile men with primary spermatogenic failure: possible negative implications on Sertoli cells.
Infertility, Male
Effect of CYP1A1 gene polymorphism and psychological distress on seminal analysis parameters.
Infertility, Male
Estrogen promotes Leydig cell engulfment by macrophages in male infertility.
Infertility, Male
Polymorphisms in CYP1A1 gene are associated with male infertility in a Chinese population.
Infertility, Male
Polymorphisms in CYP1B1 modify the risk of idiopathic male infertility with abnormal semen quality.
Infertility, Male
Quantitative analysis of CCR5 chemokine receptor and cytochrome P450 aromatase transcripts in swim-up spermatozoa isolated from fertile and infertile men.
Infertility, Male
Smoking status modifies the relation between CYP1A1*2C gene polymorphism and idiopathic male infertility: the importance of gene-environment interaction analysis for genetic studies of the disease.
Infertility, Male
Targeted Mutagenesis of a Conserved Anther-Expressed P450 Gene Confers Male Sterility in Monocots.
Infertility, Male
The Cytochrome P4501A1 gene polymorphisms and idiopathic male infertility risk: a meta-analysis.
Infertility, Male
Transcriptome analysis identified aberrant gene expression in pollen developmental pathways leading to CGMS in cotton (Gossypium hirsutum L.).
Infertility, Male
Transgenic mice expressing p450 aromatase as a model for male infertility associated with chronic inflammation in the testis.
Infertility, Male
Two duplicate CYP704B1 homologous genes BnMs1 and BnMs2 are required for pollen exine formation and tapetal development in Brassica napus.
Infertility, Male
Using Transcriptome Analysis to Screen for Key Genes and Pathways Related to Cytoplasmic Male Sterility in Cotton (Gossypium hirsutum L.).
Infertility, Male
[CYP1A1 rs4646422 gene polymorphisms not correlated with male infertility in Chinese Han population].
Inflammatory Bowel Diseases
Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis.
Inflammatory Bowel Diseases
Endotoxin-mediated disturbance of hepatic cytochrome P450 function and development of endotoxin tolerance in the rat model of dextran sulfate sodium-induced experimental colitis.
Inflammatory Bowel Diseases
Genetic Polymorphisms of CYP2D6 Oxidation in Patients with Inflammatory Bowel Disease.
Inflammatory Bowel Diseases
Significance of the genetic polymorphism of CYP2D6 and NAT2 in patients with inflammatory bowel diseases.
Inflammatory Bowel Diseases
TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease.
Inflammatory Breast Neoplasms
Inflammatory breast cancer: Activation of the aryl hydrocarbon receptor and its target CYP1B1 correlates closely with Wnt5a/b-?-catenin signalling, the stem cell phenotype and disease progression.
Influenza, Human
Effect of age and degree of immune activation on cytochrome P450 3A4 activity after influenza immunization.
Influenza, Human
Effect of immobilization, cold and cold-restraint stress on liver monooxygenase activity and lipid peroxidation of influenza virus-infected mice.
Influenza, Human
Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1.
Influenza, Human
Influenza immunization does not predominantly alter levels of phenytoin, and cytochrome P-450 enzymes in epileptic patients receiving phenytoin monotherapy.
Influenza, Human
[Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced influenza-virus-associated encephalopathy]
Insulin Resistance
20-HETE Interferes with Insulin Signaling and Contributes to Obesity-Driven Insulin Resistance.
Insulin Resistance
20-Hydroxyeicosatetraenoic acid is not associated with circulating insulin in lean to overweight humans.
Insulin Resistance
A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese.
Insulin Resistance
Acupuncture does not ameliorate metabolic disturbances in the P450 aromatase inhibitor-induced rat model of polycystic ovary syndrome.
Insulin Resistance
Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice.
Insulin Resistance
Associations between plasma clozapine/N-desmethylclozapine ratio, insulin resistance and cognitive performance in patients with co-morbid obesity and ultra-treatment resistant schizophrenia.
Insulin Resistance
Author Correction: Effect of BI-1 on insulin resistance through regulation of CYP2E1.
Insulin Resistance
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Insulin Resistance
Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis.
Insulin Resistance
CHIP(-/-)-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications.
Insulin Resistance
CYP2E1 Impairs GLUT4 Gene Expression and Function: NRF2 as a Possible Mediator.
Insulin Resistance
Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance.
Insulin Resistance
Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.
Insulin Resistance
Cytochrome P450 activity and endothelial dysfunction in insulin resistance.
Insulin Resistance
Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans.
Insulin Resistance
Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA?treated HepG2 cells.
Insulin Resistance
Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis.
Insulin Resistance
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.
Insulin Resistance
High-calorie diet inflates steatogenic effects of valproic acid in mice.
Insulin Resistance
Impact of CYP1A2 and CYP2D6 polymorphisms on drug metabolism and on insulin and lipid elevations and insulin resistance in clozapine-treated patients.
Insulin Resistance
Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role.
Insulin Resistance
Inhibition of CYP2E1 attenuates myocardial dysfunction in a murine model of insulin resistance through NLRP3-mediated regulation of mitophagy.
Insulin Resistance
Inhibition of CYP4A Reduces Hepatic Endoplasmic Reticulum Stress and Features of Diabetes in Mice.
Insulin Resistance
Insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells.
Insulin Resistance
Insulin-lowering treatment reduces aromatase activity in response to follicle-stimulating hormone in women with polycystic ovary syndrome.
Insulin Resistance
Metformin, Estrogen Replacement Therapy and Gonadotropin Inhibition Fail to Improve Insulin Sensitivity in a Girl with Aromatase Deficiency.
Insulin Resistance
Overexpression of cholesterol 7?-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis.
Insulin Resistance
Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease.
Insulin Resistance
Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation.
Insulin Resistance
Reliability of total overnight salivary caffeine assessment (TOSCA) for liver function evaluation in compensated cirrhotic patients.
Insulin Resistance
Resveratrol attenuates excessive ethanol exposure induced insulin resistance in rats via improving NAD(+) /NADH ratio.
Insulin Resistance
Role of CYP2C9 polymorphism in phenytoin-related metabolic abnormalities and subclinical atherosclerosis in young adult epileptic patients.
Insulin Resistance
The antidiabetic and hepatoprotective effects of magnolol on diabetic rats induced by high-fat diet and streptozotocin.
Insulin Resistance
The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats.
Insulin Resistance
The preventive effects of aspirin on preeclampsia based on network pharmacology and bioinformatics.
Insulin Resistance
The Role of Arachidonic and Linoleic Acid Derivatives in Pathological Pregnancies and the Human Reproduction Process.
Insulin Resistance
The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases.
Insulin Resistance
Transcriptome sequencing identifies key pathways and genes involved in gastric adenocarcinoma.
Intellectual Disability
Cerebrotendinous xanthomatosis, a metabolic disease with different neurological signs: two case reports.
Intermittent Claudication
Cilostazol: new drug. Intermittent claudication: too little efficacy, too many risks.
Invasive Fungal Infections
Effects of CYP3A4 polymorphisms on the plasma concentration of voriconazole.
Invasive Fungal Infections
Impact of CYP2C19 Genotype and Drug Interactions on Voriconazole Plasma Concentrations: A Spain Pharmacogenetic-Pharmacokinetic Prospective Multicenter Study.
Invasive Fungal Infections
Impact of CYP2C19 Phenotype and Drug-Drug Interactions on Voriconazole Concentration in Pediatric Patients.
Invasive Fungal Infections
Novel insights into the complex pharmacokinetics of voriconazole: a review of its metabolism.
Iron Deficiencies
Effects of different degrees of iron deficiency on cytochrome P450 complex and pentose phosphate pathway dehydrogenases in the rat.
Iron Deficiencies
[Effect of dietary iron deficiency on the activity of the monooxygenase system of rat liver microsomes and its induction by phenobarbital]
Iron Overload
Effects of phlebotomy therapy on cytochrome P450 2e1 activity and oxidative stress markers in dysmetabolic iron overload syndrome: a randomized trial.
Iron Overload
Hepatotoxicity induced by iron overload and alcohol. Studies on the role of chelatable iron, cytochrome P450 2E1 and lipid peroxidation.
Iron Overload
Hyperinsulinemia shifted energy supply from glucose to ketone bodies in early nonalcoholic steatohepatitis from high-fat high-sucrose diet induced Bama minipigs.
Iron Overload
Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans.
Iron Overload
Role of CYP1A1, ABCG2, CYP24A1 and VDR gene polymorphisms on the evaluation of cardiac iron overload in thalassaemia patients.
Iron Overload
Role of iron in alcoholic liver disease: introduction and summary of the symposium.
Ischemic Attack, Transient
Does CYP2C19 polymorphisms affect neurological deterioration in stroke/TIA patients?: A systematic review and meta-analysis of prospective cohort studies.
Ischemic Attack, Transient
Effect of ticagrelor with clopidogrel on high on-treatment platelet reactivity in acute stroke or transient ischemic attack (PRINCE) trial: Rationale and design.
Ischemic Attack, Transient
Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack.
Ischemic Stroke
20-HETE synthesis inhibition promotes cerebral protection after intracerebral hemorrhage without inhibiting angiogenesis.
Ischemic Stroke
Association between CYP2C9 polymorphisms and ischemic stroke following endovascular neurointervention.
Ischemic Stroke
Association between cytochrome P450 promoter polymorphisms and ischemic stroke.
Ischemic Stroke
Association between genetic polymorphisms of cytochrome P450 2C19 and the risk of cerebral ischemic stroke in Chinese.
Ischemic Stroke
Association of CYP1A1 Gene Polymorphism with Ischemic Stroke in South Indian Population.
Ischemic Stroke
Association of CYP3A4*1G and CYP3A5*3 With the 1-year Outcome of Acute Ischemic Stroke in the Han Chinese Population.
Ischemic Stroke
Association of Cytochrome P450 Genetic Variants with Clopidogrel Resistance and Outcomes in Acute Ischemic Stroke.
Ischemic Stroke
Association of cytochrome P4502E1 and NAD(P)H:quinone oxidoreductase 1 genetic polymorphisms with susceptibility to large artery atherosclerotic ischemic stroke: a case-control study in the Turkish population.
Ischemic Stroke
Astrocytic cytochrome P450 4A/20-hydroxyeicosatetraenoic acid contributes to angiogenesis in the experimental ischemic stroke.
Ischemic Stroke
Clopidogrel preventive effect based on cytochrome P450 2C19 genotype in ischaemic stroke: protocol for multicentre observational study.
Ischemic Stroke
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.
Ischemic Stroke
CYP2B6 Polymorphisms Are Associated with Ischemic Stroke Risk in a Chinese Han Population.
Ischemic Stroke
CYP2C8 rs17110453 and EPHX2 rs751141 two-locus interaction increases susceptibility to ischemic stroke.
Ischemic Stroke
Cytochrome P450 Genetic Variants and Their Metabolite Levels Associated with Plaque Stability in Patients with Ischemic Stroke.
Ischemic Stroke
Cytochrome P4501A1 genotypes and smoking- and hypertension-related ischemic stroke risk.
Ischemic Stroke
Effect of CYP2C9 *11/*11 genotype on initial and long-term warfarin dose requirement and therapeutic response.
Ischemic Stroke
Effects of Triflusal and Clopidogrel on the Secondary Prevention of Stroke Based on Cytochrome P450 2C19 Genotyping.
Ischemic Stroke
Genetic Polymorphisms of ALOX5AP and CYP3A5 Increase Susceptibility to Ischemic Stroke and Are Associated with Atherothrombotic Events in Stroke Patients.
Ischemic Stroke
Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke.
Ischemic Stroke
Genotypes of vitamin K epoxide reductase, gamma-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients.
Ischemic Stroke
Increased P450 aromatase levels in post-menopausal women after acute ischemic stroke.
Ischemic Stroke
Influence of cytochrome P450 2C9*2 and 2C9*3 variants on the risk of ischemic stroke: a cross-sectional case-control study.
Ischemic Stroke
Influences of an NR1I2 polymorphism on heterogeneous antiplatelet reactivity responses to clopidogrel and clinical outcomes in acute ischemic stroke patients.
Ischemic Stroke
Interaction among CYP2C8, EPHX2, and CYP4A11 Gene Variants Significantly Increases the Risk for Ischemic Stroke in Chinese Populations.
Ischemic Stroke
Interactions Among CYP2C8, EPHX2, and CYP4A11 Variants and CYP Plasma Metabolite Levels in Ischemic Stroke.
Ischemic Stroke
Interactive Association Between CYP2C9 rs2860905 Polymorphism and Atrial Fibrillation on Ischemic Stroke in Taiwan Biobank Participants.
Ischemic Stroke
Metabolomic profiling of fatty acid biomarkers for intracerebral hemorrhage stroke.
Ischemic Stroke
Protocol for the comparison of triflusal and clopidogrel in secondary prevention of stroke based on cytochrome P450 2C19 genotyping (MASETRO study): A multicenter, randomized, open-label, parallel-group trial.
Ischemic Stroke
The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population.
Ischemic Stroke
The association of CYP1A1 genetic polymorphisms and additional gene-gene interaction with ischemic stroke in the eastern Han of China.
Jaw Cysts
Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome.
Keloid
Enhanced expression of membrane transporter and drug resistance in keloid fibroblasts.
Keratosis, Actinic
Activation and overexpression of the aryl hydrocarbon receptor contribute to cutaneous squamous cell carcinomas: an immunohistochemical study.
Ketosis
Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.
Ketosis
Pretranslational activation of cytochrome P450IIE during ketosis induced by a high fat diet.
Ketosis
The effects of non-esterified fatty acids and ?-hydroxybutyrate on the hepatic CYP2E1 in cows with clinical ketosis.
Kidney Calculi
A rapid screening of a recurrent CYP24A1 pathogenic variant opens the way to molecular testing for Idiopathic Infantile Hypercalcemia (IIH).
Kidney Calculi
Kidney function and influence of sunlight exposure in patients with impaired 24-hydroxylation of vitamin D due to CYP24A1 mutations.
Kidney Calculi
Loss-of-function mutations of CYP24A1, the vitamin D 24- hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis.
Kidney Calculi
Maternal and infantile hypercalcemia caused by vitamin-D-hydroxylase mutations and vitamin D intake.
Kidney Diseases
CYP2C9 genotype and pharmacodynamic responses to losartan in patients with primary and secondary kidney diseases.
Kidney Diseases
CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients.
Kidney Diseases
CYP3A4 and CYP3A5 polymorphisms and blood pressure response to amlodipine among African-American men and women with early hypertensive renal disease.
Kidney Diseases
Cytochrome P450-2E1 is involved in aging-related kidney damage in mice through increased nitroxidative stress.
Kidney Diseases
Down-regulation of hepatic CYP3A and CYP2C mediated metabolism in rats with moderate chronic kidney disease.
Kidney Diseases
Effect of renal impairment on the pharmacokinetics of bupropion and its metabolites.
Kidney Diseases
Enhanced induction of Cyp24a1 by FGF23 but low serum 24,25-dihydroxyvitamin D in CKD: implications for therapy.
Kidney Diseases
Epoxyeicosatrienoic acids: a double-edged sword in cardiovascular diseases and cancer.
Kidney Diseases
Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies.
Kidney Diseases
Proton Pump Inhibitor-Induced Galactorrhea in a Kidney Transplant Recipient: A Friend or Foe?
Kidney Diseases
The Antioxidative Role of Natural Compounds from a Green Coconut Mesocarp Undeniably Contributes to Control Diabetic Complications as Evidenced by the Associated Genes and Biochemical Indexes.
Kidney Diseases
The Uremic Toxin Indoxyl-3-Sulfate Induces CYP1A2 In Primary Human Hepatocytes.
Kidney Diseases
Ultra-rare renal diseases diagnosed with whole-exome sequencing: Utility in diagnosis and management.
Kidney Diseases
Use of Enantiomeric Bupropion and Hydroxybupropion to Assess CYP2B6 Activity in Glomerular Kidney Diseases.
Kidney Diseases, Cystic
20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.
Kidney Failure, Chronic
Assessment of individual CYP2D6 activity in extensive metabolizers with renal failure: comparison of sparteine and dextromethorphan.
Kidney Failure, Chronic
Association of CYP3A5 polymorphisms and parathyroid hormone with blood level of tacrolimus in patients with end-stage renal disease.
Kidney Failure, Chronic
Clinical determinants of calcineurin inhibitor disposition: a mechanistic review.
Kidney Failure, Chronic
CYP2D6, GST-M1 and GST-T1 enzymes: expression in parathyroid gland and association with the parathyroid hormone concentration during early renal replacement therapy.
Kidney Failure, Chronic
CYP3A5 polymorphism affects the increase in CYP3A activity after living kidney transplantation in patients with end stage renal disease.
Kidney Failure, Chronic
Down-regulation of hepatic cytochrome p450 in chronic renal failure: role of uremic mediators.
Kidney Failure, Chronic
Downregulation of hepatic cytochrome P450 in chronic renal failure.
Kidney Failure, Chronic
Downregulation of intestinal cytochrome p450 in chronic renal failure.
Kidney Failure, Chronic
Effect of uremic serum and uremic toxins on drug metabolism in human microsomes.
Kidney Failure, Chronic
Effects of chronic renal failure on kidney drug transporters and cytochrome p450 in rats.
Kidney Failure, Chronic
Effects of decreased vitamin D and accumulated uremic toxin on human CYP3A4 activity in patients with end-stage renal disease.
Kidney Failure, Chronic
Effects of serum from patients with chronic renal failure on rat hepatic cytochrome P450.
Kidney Failure, Chronic
End-stage renal disease reduces the expression of drug-metabolizing cytochrome P450s.
Kidney Failure, Chronic
Impaired Vitamin D Signaling Is Associated With Frequent Development of Renal Cell Tumor in End-stage Kidney Disease.
Kidney Failure, Chronic
Influence of the CYP2D6 polymorphism and hemodialysis on codeine disposition in patients with end-stage renal disease.
Kidney Failure, Chronic
Levels of vitamin D receptor and CYP24A1 in patients with end-stage renal disease.
Kidney Failure, Chronic
Long-term outcome of the survivors of infantile hypercalcaemia with CYP24A1 and SLC34A1 mutations.
Kidney Failure, Chronic
Possibility of Decrease in CYP1A2 Function in Patients With End-Stage Renal Disease.
Kidney Failure, Chronic
Role of parathyroid hormone in the downregulation of liver cytochrome P450 in chronic renal failure.
Kidney Failure, Chronic
The effect of chronic renal failure on drug metabolism and transport.
Kidney Failure, Chronic
Upregulation of cytochrome P450 1A2 in chronic renal failure: does oxidized tryptophan play a role?
Kidney Failure, Chronic
Utilizing physiologically based pharmacokinetic modeling to predict theoretically conceivable extreme elevation of serum flecainide concentration in an anuric hemodialysis patient with cirrhosis.
Kidney Neoplasms
Aryl hydrocarbon receptor activation by aminoflavone: new molecular target for renal cancer treatment.
Kidney Neoplasms
Association of CYP1B1 L432V polymorphism with urinary cancer susceptibility: a meta-analysis.
Kidney Neoplasms
CYP24A1 rs1570669 Variant Has a Protective Effect against Tumors of the Urinary System.
Kidney Neoplasms
Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells.
Kidney Neoplasms
Relationship Between CYP1A1 Genetic Polymorphisms and Renal Cancer in China.
Kwashiorkor
Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test.
Kwashiorkor
The pharmacokinetics of caffeine in Nigerian children suffering from malaria and kwashiorkor.
lactase deficiency
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Laryngeal Neoplasms
Association between CYP1B1 gene polymorphisms and risk factors and susceptibility to laryngeal cancer.
Laryngeal Neoplasms
CYP1A1 rs1048943 and rs4646903 polymorphisms associated with laryngeal cancer susceptibility among Asian populations: a meta-analysis.
Laryngeal Neoplasms
Functionally active duplications of the CYP2D6 gene are more prevalent among larynx and lung cancer patients.
Laryngeal Neoplasms
Genotype of Null Polymorphisms in Genes GSTM1, GSTT1, CYP1A1, and CYP1A1*2A (rs4646903 T>C)/CYP1A1*2C (rs1048943 A>G) in Patients with Larynx Cancer in Southeast Spain.
Laryngeal Neoplasms
Laryngeal cancer, aryl hydrocarbon hydroxylase inducibility and smoking. A follow-up study.
Laryngeal Neoplasms
Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses.
Laryngeal Neoplasms
Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract.
Laryngeal Neoplasms
The association of the CYP1A1 Ile462Val polymorphism with head and neck cancer risk: evidence based on a cumulative meta-analysis.
Laryngeal Neoplasms
The polymorphism of CYP2E1 Rsa I/Pst I gene and susceptibility to respiratory system cancer: a systematic review and meta-analysis of 34 studies.
Laryngeal Neoplasms
[Genetic polymorphism of cytochrome P4501A1 and susceptibility to laryngeal carcinoma]
Laryngeal Neoplasms
[Relationship between susceptibility and prognosis of laryngeal cancer and genetic polymorphisms in CYP1A1 and GSTM1]
Laryngeal Neoplasms
[Role of aryl hydrocarbon hydroxylase in developing laryngeal cancer among smokers]
Latent Tuberculosis
CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis.
Leiomyoma
Association of polymorphisms and haplotypes in the cytochrome P450 1B1 gene with uterine leiomyoma: A case control study.
Leiomyoma
Catechol-o-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells.
Leiomyoma
Combination effect of cytochrome P450 1A1 gene polymorphisms on uterine leiomyoma: A case-control study.
Leiomyoma
CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women.
Leiomyoma
CYP24A1 expression analysis in uterine leiomyoma regarding MED12 mutation profile.
Leiomyoma
Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity.
Leiomyoma
Ectopic expression of CYP24A1 circular RNA hsa_circ_0060927 in uterine leiomyomas.
Leiomyoma
Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis.
Leiomyoma
Expression of the CYP19 gene and its product aromatase cytochrome P450 in human uterine leiomyoma tissues and cells in culture.
Leiomyoma
Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in eutopic endometrium from women with endometriosis, adenomyosis, or leiomyomas.
Leiomyoma
Haplotypes of CYP1B1 and CCDC57 genes in an Afro-Caribbean female population with uterine leiomyoma.
Leiomyoma
High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome.
Leiomyoma
Human uterine leiomyoma contains low levels of 1, 25 dihdroxyvitamin D3, and shows dysregulated expression of vitamin D metabolizing enzymes.
Leiomyoma
In situ estrogen synthesized by aromatase P450 in uterine leiomyoma cells promotes cell growth probably via an autocrine/intracrine mechanism.
Leiomyoma
Inhibition of in situ expression of aromatase P450 in leiomyoma of the uterus by leuprorelin acetate.
Leiomyoma
Is genetic polymorphism of ER-alpha, CYP1A1, and CYP1B1 a risk factor for uterine leiomyoma?
Leiomyoma
Lack of Association Between ESR1 and CYP1A1 Gene Polymorphisms and Susceptibility to Uterine Leiomyoma in Female Patients of Iranian Descent.
Leiomyoma
Leu/Val SNP polymorphism of CYP1B1 and risk of uterine leiomyoma in a Black population.
Leiomyoma
Overexpression of aromatase P450 in leiomyoma tissue is driven primarily through promoter I.4 of the aromatase P450 gene (CYP19).
Leiomyoma
Polymorphisms of CYP17A1, CYP19, and androgen in Brazilian women with uterine leiomyomas.
Leiomyoma
Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium.
Leiomyoma
The role of MSP I CYP1A1 gene polymorphism in the development of uterine fibroids.
Leiomyoma
Uterine leiomyomas express a molecular pattern that lowers retinoic acid exposure.
Leiomyoma
[Effects of metformin on the expression of estrogen synthetase and ER mRNA in uterine leiomyoma tissues].
Leiomyosarcoma
Steroid hormones modulate expression of cytochrome P450 enzymes in male hamster reproductive tract and leiomyosarcomas.
Leishmaniasis
Mechanism of impairment of cytochrome P450-dependent metabolism in hamster liver during leishmaniasis.
Leishmaniasis, Visceral
Impact of visceral leishmaniasis and curative chemotherapy on cytochrome P450 activity in Brazilian patients.
Leprosy
An enlarged, adaptable active site in CYP164 family P450 enzymes, the sole P450 in Mycobacterium leprae.
Leprosy
Influence of Genetic Ancestry on INDEL Markers of NFK?1, CASP8, PAR1, IL4 and CYP19A1 Genes in Leprosy Patients.
Leprosy
Metabolism of thalidomide in human microsomes, cloned human cytochrome P-450 isozymes, and Hansen's disease patients.
Leprosy
Polymorphisms in the CYP2E1 and GSTM1 genes as possible protection factors for leprosy patients.
Leukemia
Active repression by unliganded retinoid receptors in development: less is sometimes more.
Leukemia
all-trans-Retinoic acid-induced expression and regulation of retinoic acid 4-hydroxylase (CYP26) in human promyelocytic leukemia.
Leukemia
Aryl hydrocarbon hydroxylase inducibility among primary relatives of children with leukemia or solid tumors.
Leukemia
Association between CYP1A1 Ile462Val variation and acute leukemia risk: meta-analyses including 2164 cases and 4160 controls.
Leukemia
Association between CYP2B6 polymorphism and acute leukemia in a Han population of Northwest China.
Leukemia
Association of CYP3A5*3 and CYP1A1*2C Polymorphism with Development of Acute Myeloid Leukemia in Egyptian Patients
Leukemia
Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia.
Leukemia
Chemoprotective Effect of Daphnetin Against Benzene-induced Leukemia via Alteration of CYP2E1.
Leukemia
Comparison of cytochrome P450- and peroxidase-dependent metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in human cell lines: formation of stable DNA adducts and absence of a detectable increase in apurinic sites.
Leukemia
Cytochrome P-450 family 1 in rat embryo cell culture immortalized by Rausher leukemia virus.
Leukemia
Cytochrome P450 1A1 polymorphism and childhood leukemia: an analysis of matched pairs case-control genotype data.
Leukemia
Cytochrome P450 1B1 promotes cancer cell survival via specificity protein 1 (Sp1)-mediated suppression of death receptor 4.
Leukemia
Detection of CYP2E1, a genetic biomarker of susceptibility to benzene metabolism toxicity in immortal human lymphocytes derived from the Han Chinese Population.
Leukemia
Effects of cytochrome P450 family 3 subfamily A member 5 gene polymorphisms on daunorubicin metabolism and adverse reactions in patients with acute leukemia.
Leukemia
Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures.
Leukemia
Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility.
Leukemia
Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers.
Leukemia
Genotype-Environment Interaction Analysis of NQO1, CYP2E1, and NAT2 Polymorphisms and the Risk of Childhood Acute Lymphoblastic Leukemia: A Report From the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia.
Leukemia
GSTT1 and CYP2E1 polymorphisms and trihalomethanes in drinking water: effect on childhood leukemia.
Leukemia
Homologs of Drosophila Fushi-Tarazu factor 1 map to mouse chromosome 2 and human chromosome 9q33.
Leukemia
Identification and characterization of a phenyl-thiazolyl-benzoic acid derivative as a novel RAR/RXR agonist.
Leukemia
Meta-analysis of cytochrome P4501A1 MspI gene polymorphism and childhood acute leukemia.
Leukemia
No association between cytochrome P450 2D6 gene polymorphism and risk of acute leukemia: evidence based on a meta-analysis.
Leukemia
Novel insights into etiologies of leukemia: a HuGE review and meta-analysis of CYP1A1 polymorphisms and leukemia risk.
Leukemia
Parental smoking, CYP1A1 genetic polymorphisms and childhood leukemia (Québec, Canada).
Leukemia
Pedigree analysis of aryl hydrocarbon hydroxylase inducibility in acute leukemia of childhood.
Leukemia
Polymorphisms in CYP1B1, CYP3A5, GSTT1, and SULT1A1 Are Associated with Early Age Acute Leukemia.
Leukemia
Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment.
Leukemia
Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells.
Leukemia
Role of CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 genes in the susceptibility to acute leukemias.
Leukemia
The constitutive androstane receptor is a novel therapeutic target facilitating cyclophosphamide-based treatment of hematopoietic malignancies.
Leukemia
The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia.
Leukemia
The significant role of redox system in myeloid leukemia: from pathogenesis to therapeutic applications.
Leukemia
Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms.
Leukemia
[Polymorphisms of CYP3A5 Gene in Acute Leukemia Patients and Their Role in Chemotherapy and Prognosis.]
Leukemia
[Preliminary study on polymorphism of GSTM1, CYP2E1 and NQO1 genes and risk factors of children leukemia]
Leukemia
[Relation of GSTP1 and CTP2E1 Polymorphisms with Susceptibility to Acute Leukemia.]
Leukemia
[Relationship between the CYP3A5 genetic polymorphism and susceptibility to and prognosis of childhood acute leukemia]
Leukemia
[Study on the relationship between polymorphisms of Cyp1A1, GSTM1, GSTT1 genes and the susceptibility to acute leukemia in the general population of Hunan province]
Leukemia
[The relationship between cytochrome P450, subfamily IIIA, polypeptide 5 gene and drug resistance in leukemia cell lines]
Leukemia, Lymphocytic, Chronic, B-Cell
Cytochrome P450 Allele CYP3A7*1C Associates with Adverse Outcomes in Chronic Lymphocytic Leukemia, Breast, and Lung Cancer.
Leukemia, Lymphocytic, Chronic, B-Cell
Dose adjustment of venetoclax when co-administered with posaconazole: clinical drug-drug interaction predictions using a PBPK approach.
Leukemia, Lymphocytic, Chronic, B-Cell
Effect of Azithromycin on Venetoclax Pharmacokinetics in Healthy Volunteers: Implications for Dosing Venetoclax with P-gp Inhibitors.
Leukemia, Lymphocytic, Chronic, B-Cell
Genetic polymorphisms in the metabolic pathway and non-Hodgkin lymphoma survival.
Leukemia, Lymphocytic, Chronic, B-Cell
Pharmacovigilance during ibrutinib therapy for chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) in routine clinical practice.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Association of Genetic Polymorphisms in the Influx Transporter SLCO1B3 and the Efflux Transporter ABCB1 With Imatinib Pharmacokinetics in Patients With Chronic Myeloid Leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Association of The Common CYP1A1*2C Variant (Ile462Val Polymorphism) with Chronic Myeloid Leukemia (CML) in Patients Undergoing Imatinib Therapy.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Biliary excretion of imatinib mesylate and its metabolite CGP 74588 in humans.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
CYP1A1, GST gene polymorphisms and risk of chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cytochrome P450 2C19 gene polymorphisms (CYP2C19*2 and CYP2C19*3) in chronic myeloid leukemia patients: in vitro and in silico studies.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Disposition of imatinib and its metabolite CGP74588 in a patient with chronic myelogenous leukemia and short-bowel syndrome.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Do polymorphisms in MDR1 and CYP3A5 genes influence the risk of cytogenetic relapse in patients with chronic myeloid leukemia on imatinib therapy?
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Functional polymorphism of CYP2B6 G15631T is associated with hematologic and cytogenetic response in chronic myeloid leukemia patients treated with imatinib.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Genetic polymorphism of CYP3A5 in Indian chronic myeloid leukemia patients.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Genetic polymorphisms of CYP1A1 and risk of leukemia: a meta-analysis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Impact of SLC22A1 and CYP3A5 genotypes on imatinib response in chronic myeloid leukemia: A systematic review and meta-analysis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
In Vivo Cytochrome P450 3A Isoenzyme Activity and Pharmacokinetics of Imatinib in Relation to Therapeutic Outcome in Patients With Chronic Myeloid Leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Influence of CYP1A1, GST polymorphisms and susceptibility risk of chronic myeloid leukemia in Syrian population.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Influence of CYP2C8 polymorphisms on imatinib steady-state trough level in chronic myeloid leukemia and gastrointestinal stromal tumor patients.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Influence of enzyme and transporter polymorphisms on trough imatinib concentration and clinical response in chronic myeloid leukemia patients.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Influence of MDR1 and CYP3A5 genetic polymorphisms on trough levels and therapeutic response of imatinib in newly diagnosed patients with chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
MDR1 and cytochrome P450 gene-expression profiles as markers of chemosensitivity in human chronic myelogenous leukemia cells treated with cisplatin and Ru(III) metallocomplexes.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Polymorphism analysis of CYP3A5 in myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
SLC22A1-ABCB1 haplotype profiles predict imatinib pharmacokinetics in Asian patients with chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Cytochrome P4501A1, glutathione S-transferase M1 and T1 gene polymorphisms in chronic myeloid leukemia].
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Effect of MDR1 and CYP3A5 gene polymorphisms on outcomes of patients receiving imatinib treatment for chronic myeloid leukemia].
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Relation between single Nucleotide Polymorphisms of CYP3A5 Gene and MDR1 Gene Loci and Risk of CML Cytogenetic Relapse].
Leukemia, Myeloid
Antifungal prophylaxis and novel drugs in acute myeloid leukemia: the midostaurin and posaconazole dilemma.
Leukemia, Myeloid
Cytochrome P450 (CYP) expression in human myeloblastic and lymphoid cell lines.
Leukemia, Myeloid, Acute
All-Trans Retinoic Acid Activity in Acute Myeloid Leukemia: Role of Cytochrome P450 Enzyme Expression by the Microenvironment.
Leukemia, Myeloid, Acute
APC2 and CYP1B1 methylation changes in the bone marrow of acute myeloid leukemia patients during chemotherapy.
Leukemia, Myeloid, Acute
Association between the CYP1A1 T3801C polymorphism and risk of cancer: evidence from 268 case-control studies.
Leukemia, Myeloid, Acute
Association of cytochrome P450, glutathione S-transferase and N-acetyl transferase 2 gene polymorphisms with incidence of acute myeloid leukemia.
Leukemia, Myeloid, Acute
Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia.
Leukemia, Myeloid, Acute
CYP1A1 MspI polymorphism and acute myeloid leukemia risk: meta-analyses based on 5018 subjects.
Leukemia, Myeloid, Acute
CYP1A1 polymorphisms modify overall survival in acute myeloid leukemia patients.
Leukemia, Myeloid, Acute
Dose adjustment of venetoclax when co-administered with posaconazole: clinical drug-drug interaction predictions using a PBPK approach.
Leukemia, Myeloid, Acute
Genetic polymorphisms of CYP1A1 and risk of leukemia: a meta-analysis.
Leukemia, Myeloid, Acute
Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility.
Leukemia, Myeloid, Acute
Management of Venetoclax-Posaconazole Interaction in Acute Myeloid Leukemia Patients: Evaluation of Dose Adjustments.
Leukemia, Myeloid, Acute
Over-expression of CYP2E1 mRNA and protein: implications of xenobiotic induced damage in patients with de novo acute myeloid leukemia with inv(16)(p13.1q22); CBF?-MYH11.
Leukemia, Myeloid, Acute
Polymorphisms and haplotypes of the CYP2B6 detoxification gene in the predisposition of Acute Myeloid Leukemia (AML) and induction of its cytogenetic abnormalities.
Leukemia, Myeloid, Acute
Polymorphisms of CYP1A1 and glutathione S-transferase and susceptibility to adult acute myeloid leukemia.
Leukemia, Myeloid, Acute
Prognostic Value of a CYP2B6 Gene Polymorphism in Patients with Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
The G?¹?T CYP2B6 germline polymorphism affects the risk of acute myeloid leukemia and is associated with specific chromosomal abnormalities.
Leukemia, Myeloid, Acute
Venetoclax plus cytochrome P450 inhibitors without ramp-up strategy led to low risk of tumor lysis syndrome in acute myeloid leukemia.
Leukemia, Myeloid, Acute
[Study on the relationship between polymorphisms of Cyp1A1, GSTM1, GSTT1 genes and the susceptibility to acute leukemia in the general population of Hunan province]
Leukemia, Promyelocytic, Acute
Active repression by unliganded retinoid receptors in development: less is sometimes more.
Leukemia, Promyelocytic, Acute
Identification and characterization of a phenyl-thiazolyl-benzoic acid derivative as a novel RAR/RXR agonist.
Leukemia, T-Cell
Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver.
Leukemia, T-Cell
Polymorphic genetic variations of Cytochrome P450 19A1 and T-cell leukemia 1A genes in the Tamil population.
Leukopenia
Antituberculosis Drug-Induced Adverse Events in the Liver, Kidneys, and Blood: Clinical Profiles and Pharmacogenetic Predictors.
Leukopenia
Association of vitamin D pathway genes polymorphisms with pulmonary tuberculosis susceptibility in a Chinese population.
Leukopenia
Cyclophosphamide treatment-induced leukopenia rates in ANCA-associated vasculitis are influenced by variant CYP450 2C9 genotypes.
Leukopenia
Drug related genetic polymorphisms affecting adverse reactions to methotrexate, vinblastine, doxorubicin and cisplatin in patients with urothelial cancer.
Leukopenia
Genetic polymorphisms of CYP2B6 affect the pharmacokinetics/pharmacodynamics of cyclophosphamide in Japanese cancer patients.
Leukopenia
Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity.
Leukoplakia
Polymorphism in CYP1A1 and CYP2E1 genes and susceptibility to leukoplakia in Indian tobacco users.
Leukoplakia
Prevalence of CYP1A1 and GST polymorphisms in the population of northeastern India and susceptibility of oral cancer.
Leukoplakia
Role of CYP2E1 genetic polymorphism in the development of oral leukoplakia among tobacco users in North Indian population.
Leukoplakia, Oral
Carnosol, a Constituent of Zyflamend, Inhibits Aryl Hydrocarbon Receptor-Mediated Activation of CYP1A1 and CYP1B1 Transcription and Mutagenesis.
Leukoplakia, Oral
Genetic polymorphisms of carcinogen metabolizing enzymes are associated with oral leukoplakia development and p53 overexpression.
Leukoplakia, Oral
Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation.
Leukoplakia, Oral
Role of CYP2E1 genetic polymorphism in the development of oral leukoplakia among tobacco users in North Indian population.
Lewy Body Disease
Alternative splicing patterns of CYP2D genes in human brain and neurodegenerative disorders.
Lewy Body Disease
CYP2D6 polymorphisms in Alzheimer's disease, with and without extrapyramidal signs, showing no apolipoprotein E epsilon 4 effect modification.
Lewy Body Disease
Genetic polymorphism of cytochrome P450 2D6 in idiopathic Parkinson disease and diffuse Lewy body disease.
Lewy Body Disease
No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian population.
Leydig Cell Tumor
Elevated levels of the Steroidogenic Factor-1 are associated with over-expression of CYP19 in an Estrogen producing testicular Leydig cell tumour.
Leydig Cell Tumor
Primary amenorrhea revealing an occult progesterone-secreting ovarian tumor.
Li-Fraumeni Syndrome
p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling.
Lichen Planus, Oral
Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk.
Lichen Planus, Oral
Cytochrome P450 2D6 polymorphism and drug utilization in patients with oral lichen planus.
Lichen Planus, Oral
Oral lichen planus and intake of drugs metabolized by polymorphic cytochrome P450 enzymes.
Lichen Planus, Oral
Subgrouping of patients with oral lichen planus according to cytochrome P450 enzyme phenotype and genotype.
Lipid Metabolism Disorders
Transcriptome analysis in normal human liver cells exposed to 2, 3, 3', 4, 4', 5 - Hexachlorobiphenyl (PCB 156).
Lipid Metabolism Disorders
Transcriptome analysis of the effects of chitosan on the hyperlipidemia and oxidative stress in high-fat diet fed mice.
Lissencephaly
Genome-wide association analysis of panicle exsertion and uppermost internode in rice (Oryza sativa L.).
Listeriosis
Factors involved in the down-regulation of cytochrome P450 during Listeria monocytogenes infection.
Listeriosis
Listeriosis downregulates hepatic cytochrome P450 enzymes in sublethal murine infection.
Liver Abscess, Amebic
Antipyrine clearance, aminopyrine N-demethylase, and bilirubin UDP-glucuronyl transferase activity in patients with amoebic liver abscess.
Liver Cirrhosis
2-(Allylthio)pyrazine, a cancer chemopreventive agent, inhibits liver fibrosis induced by dimethylnitrosamine in rats: role of inhibition of transforming growth factor-beta1 expression.
Liver Cirrhosis
A proteomic analysis of thioacetamide-induced hepatotoxicity and cirrhosis in rat livers.
Liver Cirrhosis
Ascorbic acid supplementation down-regulates the alcohol induced oxidative stress, hepatic stellate cell activation, cytotoxicity and mRNA levels of selected fibrotic genes in guinea pigs.
Liver Cirrhosis
Beneficial effects of Vitis coignetiae Pulliat leaves on nonalcoholic steatohepatitis in a rat model.
Liver Cirrhosis
Chemical induced inflammation of the liver breaks tolerance and results in autoimmune hepatitis in Balb/c mice.
Liver Cirrhosis
Chemical profile of Swertia mussotii Franch and its potential targets against liver fibrosis revealed by cross-platform metabolomics.
Liver Cirrhosis
Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease.
Liver Cirrhosis
Cytochrome P450 2D6 polymorphism is a molecular genetic marker of liver cirrhosis progression.
Liver Cirrhosis
Cytochrome p450 dysregulations in thioacetamide-induced liver cirrhosis in rats and the counteracting effects of hepatoprotective agents.
Liver Cirrhosis
Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis.
Liver Cirrhosis
Cytochromes P4502E1 and P4501A1 genotypes and susceptibility to cirrhosis or upper aerodigestive tract cancer in alcoholic caucasians.
Liver Cirrhosis
Date fruits inhibit hepatocyte apoptosis and modulate the expression of hepatocyte growth factor, cytochrome P450 2E1 and heme oxygenase-1 in carbon tetrachloride-induced liver fibrosis.
Liver Cirrhosis
Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients.
Liver Cirrhosis
Detecting serum and urine metabolic profile changes of CCl4-liver fibrosis in rats at 12 weeks based on gas chromatography-mass spectrometry.
Liver Cirrhosis
Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases.
Liver Cirrhosis
Differential Effect of Liver Cirrhosis on the Pregnane X Receptor-Mediated Induction of CYP3A1 and 3A2 in the Rat.
Liver Cirrhosis
Dysregulation of UDP-glucuronosyltransferases in CCl4 induced liver injury rats.
Liver Cirrhosis
Effect of the CYP2E1 genotype on vinyl chloride monomer-induced liver fibrosis among polyvinyl chloride workers.
Liver Cirrhosis
Effects of zedoary turmeric oil on P450 activities in rats with liver cirrhosis induced by thioacetamide.
Liver Cirrhosis
Ethanol-inducible cytochrome P4502E1: genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease.
Liver Cirrhosis
Fatal rhabdomyolysis in a patient with liver cirrhosis after switching from simvastatin to fluvastatin.
Liver Cirrhosis
Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity.
Liver Cirrhosis
Genetic Variants of Alcohol Metabolizing Enzymes and Alcohol-Related Liver Cirrhosis Risk.
Liver Cirrhosis
Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis.
Liver Cirrhosis
Hepato-protective role of itraconazole mediated cytochrome p450 pathway inhibition in liver fibrosis.
Liver Cirrhosis
Immunohistochemical study of CYP2E1 in hepatocellular carcinoma carcinogenesis: examination with newly prepared anti-human CYP2E1 antibody.
Liver Cirrhosis
Impaired androgen 16 alpha-hydroxylation in hepatic microsomes from carbon tetrachloride-cirrhotic male rats.
Liver Cirrhosis
Liver dysfunction markedly decreases the inhibition of cytochrome P450 1A2-mediated theophylline metabolism by fluvoxamine.
Liver Cirrhosis
Long-term administration of tacrolimus and everolimus prevents high cholesterol-high fructose-induced steatosis in C57BL/6J mice by inhibiting de-novo lipogenesis.
Liver Cirrhosis
Melatonin serum levels and metabolic clearance rate in patients with liver cirrhosis.
Liver Cirrhosis
Metabolism of the A1 adenosine receptor PET ligand [18F]CPFPX by CYP1A2: implications for bolus/infusion PET studies.
Liver Cirrhosis
Metabolomics combined with network pharmacology exploration reveals the modulatory properties of Astragali Radix extract in the treatment of liver fibrosis.
Liver Cirrhosis
Overexpression of P-glycoprotein, MRP2, and CYP3A4 impairs intestinal absorption of octreotide in rats with portal hypertension.
Liver Cirrhosis
Pharmacokinetic parameters of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, after intravenous and oral administration of chlorzoxazone to liver cirrhotic rats with diabetes mellitus.
Liver Cirrhosis
Pharmacokinetics of dl-praeruptorin A after single-dose intravenous administration to rats with liver cirrhosis.
Liver Cirrhosis
Polyamine biosynthesis and monooxygenase enzyme activity in rat liver cirrhosis and regeneration.
Liver Cirrhosis
Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics.
Liver Cirrhosis
Reliability of total overnight salivary caffeine assessment (TOSCA) for liver function evaluation in compensated cirrhotic patients.
Liver Cirrhosis
Role of CYP2D6 polymorphism in predicting liver fibrosis progression rate in Caucasian patients with chronic hepatitis C.
Liver Cirrhosis
Role of CYP2E1 in the metabolism of ethanol in patients with liver cirrhosis.
Liver Cirrhosis
Severe liver cirrhosis markedly reduces AhR-mediated induction of cytochrome P450 in rats by decreasing the transcription of target genes.
Liver Cirrhosis
The effect of liver cirrhosis on the regulation and expression of drug metabolizing enzymes.
Liver Cirrhosis
The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes.
Liver Cirrhosis
Vitamin D serum level is associated with Child-Pugh score and metabolic enzyme imbalances, but not viral load in chronic hepatitis B patients.
Liver Cirrhosis
[Drug-induced pneumonitis in a patient treated with venlafaxine and propanolol]
Liver Cirrhosis
[Effect of Fuzheng Huayu recipe on CYP450 isozymes in normal and liver fibrosis rats].
Liver Cirrhosis
[Study on CYP1A2, CYP2C9/10 and CYP2C19 activities in rats to create liver cirrhosis by using multi-factor complex].
Liver Cirrhosis
[The influence of genetic polymorphism of CYP2E1 on the development of alcohol liver cirrhosis]
Liver Cirrhosis, Alcoholic
Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study.
Liver Cirrhosis, Alcoholic
Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population.
Liver Cirrhosis, Alcoholic
Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis.
Liver Cirrhosis, Alcoholic
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice.
Liver Cirrhosis, Alcoholic
Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases.
Liver Cirrhosis, Alcoholic
Free radical mechanisms in immune reactions associated with alcoholic liver disease.
Liver Cirrhosis, Alcoholic
Genetic Polymorphisms of Genes Coding to Alcohol-Metabolizing Enzymes in Western Mexicans: Association of CYP2E1*c2/CYP2E1*5B Allele with Cirrhosis and Liver Function.
Liver Cirrhosis, Alcoholic
Induction of blood lymphocyte cytochrome P450 2E1 in early stage alcoholic liver cirrhosis.
Liver Cirrhosis, Alcoholic
Molecular Mechanisms Involved in the Interaction Effects of Alcohol and HCV in Liver Cirrhosis.
Liver Cirrhosis, Alcoholic
Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis.
Liver Cirrhosis, Alcoholic
Polymorphism in glutathione-S-transferases: a risk factor in alcoholic liver cirrhosis.
Liver Cirrhosis, Alcoholic
Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics.
Liver Cirrhosis, Biliary
13C-methacetin breath test correlates with clinical indices of liver disease severity in patients with primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Differential alteration of cytochrome P450 isoenzymes in two experimental models of cirrhosis.
Liver Cirrhosis, Biliary
Multidrug resistance 1 genotype and disposition of budesonide in early primary biliary cirrhosis.
Liver Cirrhosis, Biliary
No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis.
Liver Cirrhosis, Experimental
Pharmacokinetics of dl-praeruptorin A after single-dose intravenous administration to rats with liver cirrhosis.
Liver Cirrhosis, Experimental
Pharmacokinetics of oltipraz in diabetic rats with liver cirrhosis.
Liver Diseases
?-Imidazolyl-alkyl derivatives as new preclinical drug candidates for treating non-alcoholic steatohepatitis.
Liver Diseases
A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma.
Liver Diseases
A study on the pharmacokinetics of chlorzoxazone in healthy Thai volunteers.
Liver Diseases
Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against cytochrome P450 2E1-dependent toxicity in HepG2 cells.
Liver Diseases
Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver.
Liver Diseases
Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease.
Liver Diseases
Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis.
Liver Diseases
Apoptosis of enterocytes and nitration of junctional complex proteins promote alcohol-induced gut leakiness and liver injury.
Liver Diseases
Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population.
Liver Diseases
Association of CYP2C9, CYP2A6, ACSM2A, and CPT1A gene polymorphisms with adverse effects of valproic acid in Chinese patients with epilepsy.
Liver Diseases
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Liver Diseases
Case Report: Ursodeoxycholic acid treatment in Niemann-Pick disease type C; clinical experience in four cases.
Liver Diseases
Changes in caffeine, lidocaine and trimethadione metabolism in carbon tetrachloride-intoxicated rats as assessed by a "cocktail" study.
Liver Diseases
Clinical importance of non-genetic and genetic cytochrome P450 function tests in liver disease.
Liver Diseases
Comparing the protective effects of three sulfur compounds against acrylonitrile-induced acute toxicity in CYP2E1-induced rats.
Liver Diseases
Comparison of Circulating, Hepatocyte Specific Messenger RNA and microRNA as Biomarkers for Chronic Hepatitis B and C.
Liver Diseases
Comparison of the polymorphic regions of the cytochrome P450 CYP2E1 gene of humans and patas and cynomolgus monkeys.
Liver Diseases
CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer.
Liver Diseases
CYP1A1 and MT1K are congener specific biomarker genes for liver diseases induced by PCBs.
Liver Diseases
CYP1A2 is a predictor of HCC recurrence in HCV-related chronic liver disease: A retrospective multicentric validation study.
Liver Diseases
CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model.
Liver Diseases
Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis.
Liver Diseases
CYP2C19 Polymorphisms and Therapeutic Drug Monitoring of Voriconazole: Are We Ready for Clinical Implementation of Pharmacogenomics?
Liver Diseases
CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.
Liver Diseases
CYP2E1 and Oxidant Stress in Alcoholic and Non-Alcoholic Fatty Liver Disease.
Liver Diseases
CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload.
Liver Diseases
CYP3A suppression during diet-induced nonalcoholic fatty liver disease is independent of PXR regulation.
Liver Diseases
Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice.
Liver Diseases
Cytochrome P450 1A2 is a hepatic autoantigen in autoimmune polyglandular syndrome type 1.
Liver Diseases
Cytochrome P450 2A5 Constitutive Expression and Induction by Heavy Metals Is Dependent on Redox-Sensitive Transcription Factor Nrf2 in Liver.
Liver Diseases
Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects.
Liver Diseases
Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.
Liver Diseases
Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications.
Liver Diseases
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Liver Diseases
Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis.
Liver Diseases
Cytochrome P450-2E1 promotes aging-related hepatic steatosis, apoptosis and fibrosis through increased nitroxidative stress.
Liver Diseases
Cytochrome P4502E1 (CYP2E1) expression in peripheral blood lymphocytes: evaluation in hepatitis C and diabetes.
Liver Diseases
Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases.
Liver Diseases
Cytochromes P450 and uridine triphosphate-glucuronosyltransferases: model autoantigens to study drug-induced, virus-induced, and autoimmune liver disease.
Liver Diseases
Defining a relationship between dietary fatty acids and the cytochrome P450 system in a mouse model of fatty liver disease.
Liver Diseases
Delphi Consensus Recommendations on Management of Dosing, Adverse Events, and Comorbidities in the Treatment of Idiopathic Pulmonary Fibrosis with Nintedanib.
Liver Diseases
Depression of peripheral blood monocyte aryl hydrocarbon hydroxylase activity in patients with liver disease: possible involvement of macrophage factors.
Liver Diseases
Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans.
Liver Diseases
Diet-induced non-alcoholic fatty liver disease affects expression of major cytochrome P450 genes in a mouse model.
Liver Diseases
Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection.
Liver Diseases
Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases.
Liver Diseases
Differential alteration of cytochrome P450 isoenzymes in two experimental models of cirrhosis.
Liver Diseases
Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease.
Liver Diseases
Differential Effect of Liver Cirrhosis on the Pregnane X Receptor-Mediated Induction of CYP3A1 and 3A2 in the Rat.
Liver Diseases
Dihydropyrimidine dehydrogenase activity and fluorouracil pharmacokinetics with liver damage induced by bile duct ligation in rats.
Liver Diseases
Donor graft does not affect the P450 2C19 genotype expressed in peripheral blood in recipients of living donor liver transplantation.
Liver Diseases
Drug metabolism in liver disease: activity of hepatic microsomal metabolizing enzymes.
Liver Diseases
Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase.
Liver Diseases
Effect of the CYP3A4 inhibitor erythromycin on the pharmacokinetics of lignocaine and its pharmacologically active metabolites in subjects with normal and impaired liver function.
Liver Diseases
Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism.
Liver Diseases
Effects of Short- and Long-Term Soy Protein Feeding on Hepatic Cytochrome P450 Expression in Obese Nonalcoholic Fatty Liver Disease Rat Model.
Liver Diseases
Establishing population distribution of drug-metabolizing enzyme activities for the use of salivary caffeine as a dynamic liver function marker in a Singaporean Chinese population.
Liver Diseases
Establishment of an ex Vivo Model of Nonalcoholic Fatty Liver Disease Using a Tissue-Engineered Liver.
Liver Diseases
Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes.
Liver Diseases
Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation.
Liver Diseases
Expression of Cytochrome P450 2A5 in a C57BL/6J Mouse Model of Nonalcoholic Fatty Liver Disease.
Liver Diseases
Expression of genes involved in xenobiotic metabolism and transport in end-stage liver disease: up-regulation of ABCC4 and CYP1B1.
Liver Diseases
Expression of P450 and nuclear receptors in normal and end-stage Chinese livers.
Liver Diseases
Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1.
Liver Diseases
Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease.
Liver Diseases
Genetic polymorphism of human CYP2E1: characterization of two variant alleles.
Liver Diseases
Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.
Liver Diseases
Genetic polymorphisms of CYP2E1 and DNA repair genes HOGG1 and XRCC1: Association with hepatitis B related advanced liver disease and cancer.
Liver Diseases
Genetic Polymorphisms of Cytochrome P4501A1 (CYP1A1) and Glutathione S-Transferase P1 (GSTP1) and Risk of Hepatocellular Carcinoma Among Chronic Hepatitis C Patients in Egypt.
Liver Diseases
Genetic polymorphisms of the hepatic pathways of fatty liver disease after living donor liver transplantation.
Liver Diseases
Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.
Liver Diseases
Hepatitis C virus infection associated with liver-kidney microsomal antibody type 1 (LKM1) autoantibodies in children.
Liver Diseases
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.
Liver Diseases
Hepatoprotective Effect of Seed Coat ofEuryale ferox Extract in Non-alcoholic Fatty Liver Disease Induced by High-fat Diet in Mice by Increasing IRs-1 and Inhibiting CYP2E1.
Liver Diseases
High-Selectivity Fluorescent Reporter toward Peroxynitrite in a Coexisting Nonalcoholic Fatty Liver and Drug-Induced Liver Diseases Model.
Liver Diseases
Higher chlorzoxazone clearance in obese children compared with nonobese peers.
Liver Diseases
Histone Methyltransferase G9a Regulates Expression of Nuclear Receptors and Cytochrome P450 Enzymes in HepaRG Cells at Basal Level and in Fatty Acid Induced Steatosis.
Liver Diseases
Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine.
Liver Diseases
Impaired irinotecan biotransformation in hepatic microsomal fractions from patients with chronic liver disease.
Liver Diseases
In vitro cytochrome p450 activity decreases in children with high pediatric end-stage liver disease scores.
Liver Diseases
In vivo metabolic activity of CYP2C19 and CYP3A in relation to CYP2C19 genetic polymorphism in chronic liver disease.
Liver Diseases
Increased cytochrome P-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-alpha.
Liver Diseases
Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role.
Liver Diseases
Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1.
Liver Diseases
Independent patterns of cytochrome P450 gene expression in liver and blood in patients with suspected liver disease.
Liver Diseases
Induction of cytochrome P450 enzymes and generation of protein-aldehyde adducts are associated with sex-dependent sensitivity to alcohol-induced liver disease in micropigs.
Liver Diseases
Inflammation-induced phenoconversion of polymorphic drug metabolizing enzymes: hypothesis with implications for personalized medicine.
Liver Diseases
Influence of chronic hepatitis C infection on cytochrome P450 3a4 activity using midazolam as an in vivo probe substrate.
Liver Diseases
Influence of clinicopathological variables on CYP protein expression in human liver.
Liver Diseases
Influence of liver disease and environmental factors on hepatic monooxygenase activity in vitro.
Liver Diseases
Influence of rifampin on serum markers of cholesterol and bile acid synthesis in men.
Liver Diseases
Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers.
Liver Diseases
Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population.
Liver Diseases
Interaction of heterogeneous nuclear ribonucleoprotein A1 with cytochrome P450 2A6 mRNA: implications for post-transcriptional regulation of the CYP2A6 gene.
Liver Diseases
Interleukin-1, platelet derived growth factor, free radicals and monocyte aryl hydrocarbon hydroxylase activity in liver disease. Role of cell communication.
Liver Diseases
Investigation of the genetic markers associated with alcoholic liver diseases.
Liver Diseases
Laboratory and clinical outcomes of pharmacogenetic vs. clinical protocols for warfarin initiation in orthopedic patients.
Liver Diseases
Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice.
Liver Diseases
Liver dysfunction markedly decreases the inhibition of cytochrome P450 1A2-mediated theophylline metabolism by fluvoxamine.
Liver Diseases
Liver-enriched transcription factor expression relates to chronic hepatic failure in humans.
Liver Diseases
Localization of CYP4B1 in the rat nasal cavity and analysis of CYPs as secreted proteins.
Liver Diseases
Measurement and diagnostic use of hepatic cytochrome P450 metabolism of oleic acid in liver disease.
Liver Diseases
Mining for Oxysterols in Cyp7b1-/- Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5.
Liver Diseases
Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors.
Liver Diseases
Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis.
Liver Diseases
Monocyte aryl hydrocarbon hydroxylase (AHH) activity mimics Kupffer cell and hepatocyte AHH activity in an animal model of liver disease.
Liver Diseases
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Diseases
Nanoformulated SOD1 ameliorates the combined NASH and alcohol-associated liver disease partly via regulating CYP2E1 expression in adipose tissue and liver.
Liver Diseases
Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model.
Liver Diseases
Nonalcoholic Fatty Liver Disease (NAFLD) and Hepatic Cytochrome P450 (CYP) Enzymes.
Liver Diseases
Normal-release and controlled-release oxycodone: pharmacokinetics, pharmacodynamics, and controversy.
Liver Diseases
Optimizing combination of liver-enriched transcription factors and nuclear receptors simultaneously favors ammonia and drug metabolism in liver cells.
Liver Diseases
Overexpression of CYP2E1 in Mitochondria Sensitizes HepG2 Cells to the Toxicity Caused by Depletion of Glutathione.
Liver Diseases
Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease.
Liver Diseases
P450 enzymes. Inhibition mechanisms, genetic regulation and effects of liver disease.
Liver Diseases
Patients with type II autoimmune hepatitis express functionally intact cytochrome P-450 db1 that is inhibited by LKM-1 autoantibodies in vitro but not in vivo.
Liver Diseases
Pharmacokinetic assessment of nevirapine and metabolites in human immunodeficiency virus type 1-infected patients with hepatic fibrosis.
Liver Diseases
Pharmacological Mechanisms Underlying the Hepatoprotective Effects of Ecliptae herba on Hepatocellular Carcinoma.
Liver Diseases
Population Pharmacokinetic/Pharmacodynamic Analyses of Avatrombopag in Patients With Chronic Liver Disease and Optimal Dose Adjustment Guide With Concomitantly Administered CYP3A and CYP2C9 Inhibitors.
Liver Diseases
Potential role of gut microbiota, the proto-oncogene PIKE (Agap2) and cytochrome P450 CYP2W1 in promotion of liver cancer by alcoholic and nonalcoholic fatty liver disease and protection by dietary soy protein.
Liver Diseases
Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis.
Liver Diseases
Proceedings: The relation between cytochrome P450 in liver biopsies and drug metabolism in patients with liver disease and in morphine addiction.
Liver Diseases
Quantitation of cytochrome P450 mRNAs in patients with suspected liver diseases as assessed by reverse transcriptase-polymerase chain reaction.
Liver Diseases
Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism.
Liver Diseases
Regulation of the cytochrome P450 epoxyeicosanoid pathway is associated with distinct histologic features in pediatric non-alcoholic fatty liver disease.
Liver Diseases
Relationship between antipyrine metabolism and acetylation phenotype in health and chronic liver diseases.
Liver Diseases
Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients.
Liver Diseases
Reliability of total overnight salivary caffeine assessment (TOSCA) for liver function evaluation in compensated cirrhotic patients.
Liver Diseases
Role of CYP2E1 gene polymorphisms association with hepatitis risk in Northeast India.
Liver Diseases
Role of iron in alcoholic liver disease: introduction and summary of the symposium.
Liver Diseases
RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma.
Liver Diseases
Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6.
Liver Diseases
Severe liver cirrhosis markedly reduces AhR-mediated induction of cytochrome P450 in rats by decreasing the transcription of target genes.
Liver Diseases
Severe Neonatal Cholestasis in Cerebrotendinous Xanthomatosis: Genetics, Immunostaining, Mass Spectrometry.
Liver Diseases
Single copy of variant CYP2A6 alleles does not confer susceptibility to liver dysfunction in patients treated with coumarin.
Liver Diseases
Sorafenib-induced liver failure: a case report and review of the literature.
Liver Diseases
TA allele of rs2070673 in the CYP2E1 gene is associated with lobular inflammation and nonalcoholic steatohepatitis in patients with biopsy-proven nonalcoholic fatty liver disease.
Liver Diseases
Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice.
Liver Diseases
The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease.
Liver Diseases
The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.
Liver Diseases
The RsaI polymorphism of CYP2E1 and susceptibility to alcoholic liver disease in Caucasians: effect on age of presentation and dependence on alcohol dehydrogenase genotype.
Liver Diseases
Total sesquiterpene glycosides from Loquat (Eriobotrya japonica) leaf alleviate high-fat diet induced non-alcoholic fatty liver disease through cytochrome P450 2E1 inhibition.
Liver Diseases
Transcriptional Repression of CYP3A4 by Increased miR-200a-3p and miR-150-5p Promotes Steatosis in vitro.
Liver Diseases
Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease.
Liver Diseases
Two cytochromes P450 are major hepatocellular autoantigens in autoimmune polyglandular syndrome type 1.
Liver Diseases
Vitamin D serum level is associated with Child-Pugh score and metabolic enzyme imbalances, but not viral load in chronic hepatitis B patients.
Liver Diseases
Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models.
Liver Diseases
[Influence of electroacupuncture on hepatic cytochrome P450 1 A 1 expression and lipid peroxidation in nonalcoholic fatty liver rats]
Liver Diseases
[The eye as target of adverse ocular drug reactions. Focus on systemic antiinfective therapy].
Liver Diseases
[The role of cytochrome P450 in nonalcoholic fatty liver induced by high-fat diet: a gene expression profile analysis].
Liver Diseases, Alcoholic
Characterization of novel cytochrome P450 2E1 knockout rat model generated by CRISPR/Cas9.
Liver Diseases, Alcoholic
Clomethiazole inhibits cytochrome P450 2E1 and improves alcoholic liver disease.
Liver Diseases, Alcoholic
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis.
Liver Diseases, Alcoholic
CYP2E1 expression in human lymphocytes from various ethnic populations.
Liver Diseases, Alcoholic
CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload.
Liver Diseases, Alcoholic
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice.
Liver Diseases, Alcoholic
Cytochrome P450 2E1 expression induces hepatocyte resistance to cell death from oxidative stress.
Liver Diseases, Alcoholic
Cytochrome P4502E1 inducibility and hydroxyethyl radical formation among alcoholics.
Liver Diseases, Alcoholic
Cytochrome P4502E1 primes macrophages to increase TNF-alpha production in response to lipopolysaccharide.
Liver Diseases, Alcoholic
Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases.
Liver Diseases, Alcoholic
Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome P4502E1.
Liver Diseases, Alcoholic
Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase.
Liver Diseases, Alcoholic
Effect of ALDH2 and CYP2E1 gene polymorphisms on drinking behavior and alcoholic liver disease in Japanese male workers.
Liver Diseases, Alcoholic
Effects of dietary fat composition on activities of the microsomal ethanol oxidizing system and ethanol-inducible cytochrome P450 (CYP2E1) in the liver of rats chronically fed ethanol.
Liver Diseases, Alcoholic
Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5.
Liver Diseases, Alcoholic
Estrogen-related receptor ? controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol.
Liver Diseases, Alcoholic
Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2.
Liver Diseases, Alcoholic
Expression of the peroxisome proliferator-activated receptor gene is decreased in experimental alcoholic liver disease.
Liver Diseases, Alcoholic
Genetic polymorphism of cytochrome P450. Functional consequences and possible relationship to disease and alcohol toxicity.
Liver Diseases, Alcoholic
Genetic repeat polymorphism in the regulating region of CYP2E1: frequency and relationship with enzymatic activity in alcoholics.
Liver Diseases, Alcoholic
Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis.
Liver Diseases, Alcoholic
Human lymphocyte cytochrome P450 2E1, a putative marker for alcohol-mediated changes in hepatic chlorzoxazone activity.
Liver Diseases, Alcoholic
Influence of royal jelly on mouse hepatic gene expression and safety assessment with a DNA microarray.
Liver Diseases, Alcoholic
Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole.
Liver Diseases, Alcoholic
Intragastric ethanol infusion model for cellular and molecular studies of alcoholic liver disease.
Liver Diseases, Alcoholic
Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats.
Liver Diseases, Alcoholic
Mutations in the exons and exon-intron junction regions of human cytochrome P-4502E1 gene and alcoholism.
Liver Diseases, Alcoholic
Mutations in the Exons and Exon-Intron Junction Regions of Human Cytochrome P-4502E1 Gene and Alcoholism.
Liver Diseases, Alcoholic
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Diseases, Alcoholic
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Liver Diseases, Alcoholic
Polymorphism in the cytochrome P450 2E1 gene and the risk of alcoholic liver disease.
Liver Diseases, Alcoholic
Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage.
Liver Diseases, Alcoholic
Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling.
Liver Diseases, Alcoholic
Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system.
Liver Diseases, Alcoholic
Role of CYP2E1 in the pathogenesis of alcoholic liver disease: modifications by cAMP and ubiquitin-proteasome pathway.
Liver Diseases, Alcoholic
Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity.
Liver Diseases, Alcoholic
Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1.
Liver Diseases, Alcoholic
Role of iron in alcoholic liver disease: introduction and summary of the symposium.
Liver Diseases, Alcoholic
ROR? switches transcriptional mode of ERR? that results in transcriptional repression of CYP2E1 under ethanol-exposure.
Liver Diseases, Alcoholic
SUMOylation regulates cytochrome P450 2E1 expression and activity in alcoholic liver disease.
Liver Diseases, Alcoholic
Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells.
Liver Diseases, Alcoholic
The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice.
Liver Diseases, Alcoholic
The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.
Liver Diseases, Alcoholic
The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model.
Liver Diseases, Alcoholic
The Importance of CYP2E1 in the Pathogenesis of Alcoholic Liver Disease and Drug Toxicity and the Role of the Proteasome.
Liver Diseases, Alcoholic
The RsaI polymorphism of CYP2E1 and susceptibility to alcoholic liver disease in Caucasians: effect on age of presentation and dependence on alcohol dehydrogenase genotype.
Liver Diseases, Alcoholic
Use of dietary saturated fatty acids and vitamin E in the treatment of alcoholic liver disease.
Liver Diseases, Alcoholic
Use of molecular simulation for mapping conformational CYP2E1 epitopes.
Liver Diseases, Alcoholic
Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models.
Liver Diseases, Alcoholic
[Relationship among hepatocyte apoptosis, P450 2E1 and oxidative stress in alcoholic liver disease of rats]
Liver Failure
Alginate-encapsulated human hepatoblastoma cells in an extracorporeal perfusion system improve some systemic parameters of liver failure in a xenogeneic model.
Liver Failure
Decellularized Liver Matrix-Modified Cryogel Scaffolds as Potential Hepatocyte Carriers in Bioartificial Liver Support Systems and Implantable Liver Constructs.
Liver Failure
Hepatic Failure From Pennyroyal Tea Interaction With Medications Metabolized by the Cytochrome P450 Enzymes.
Liver Failure
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Liver Failure
IgG3 is the dominant subtype of anti-isoniazid antibodies in patients with isoniazid-induced liver failure.
Liver Failure
Involvement of cytochrome P450 in cisplatin treatment: implications for toxicity.
Liver Failure
Tolterodine: a new antimuscarinic agent for the treatment of the overactive bladder.
Liver Failure, Acute
A non-hepatotropic parasite infection increases mortality in the acetaminophen-induced acute liver failure murine model: possible roles for IL-5 and IL-6.
Liver Failure, Acute
Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1.
Liver Failure, Acute
Alginate-encapsulated human hepatoblastoma cells in an extracorporeal perfusion system improve some systemic parameters of liver failure in a xenogeneic model.
Liver Failure, Acute
Bile Acid Signaling Is Involved in the Neurological Decline in a Murine Model of Acute Liver Failure.
Liver Failure, Acute
Melatonin protects against apoptosis-inducing factor (AIF)-dependent cell death during acetaminophen-induced acute liver failure.
Liver Failure, Acute
Myristica fragrans Kernels Prevent Paracetamol-Induced Hepatotoxicity by Inducing Anti-Apoptotic Genes and Nrf2/HO-1 Pathway.
Liver Failure, Acute
Protection against acetaminophen-induced acute liver failure by omentum adipose tissue derived stem cells through the mediation of Nrf2 and cytochrome P450 expression.
Liver Failure, Acute
Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in rats.
Liver Failure, Acute
Sanghuangporus sanghuang Mycelium Prevents Paracetamol-Induced Hepatotoxicity through Regulating the MAPK/NF-?B, Keap1/Nrf2/HO-1, TLR4/PI3K/Akt, and CaMKK?/LKB1/AMPK Pathways and Suppressing Oxidative Stress and Inflammation.
Liver Neoplasms
Bioinformatic analysis reveals CYP2C9 as a potential prognostic marker for HCC and liver cancer cell lines suitable for its mechanism study.
Liver Neoplasms
Cellular Metabolism in High-Throughput In Vitro Reporter Gene Assays and Implications for the Quantitative In Vitro-In Vivo Extrapolation.
Liver Neoplasms
CYP1A1 and CYP1A2 expression levels are differentially regulated in three-dimensional spheroids of liver cancer cells compared to two-dimensional monolayer cultures.
Liver Neoplasms
CYP2C8 regulated by GAS5/miR-382-3p exerts anti-cancerous properties in liver cancer.
Liver Neoplasms
CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload.
Liver Neoplasms
CYP2E1 RsaI/PstI polymorphism and liver cancer risk among east Asians: a HuGE review and meta-analysis.
Liver Neoplasms
Cytochrome P450 1A2 Metabolizes 17?-Estradiol to Suppress Hepatocellular Carcinoma.
Liver Neoplasms
Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: induction of cytochrome P-450 3A4.
Liver Neoplasms
Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism.
Liver Neoplasms
Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients.
Liver Neoplasms
Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes.
Liver Neoplasms
Hypoxia as a modulator of cytochromes P450: Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia.
Liver Neoplasms
Immunohistochemical study of CYP2E1 in hepatocellular carcinoma carcinogenesis: examination with newly prepared anti-human CYP2E1 antibody.
Liver Neoplasms
In vitro metabolism of aflatoxin B1 by normal and tumorous liver tissue from Thailand.
Liver Neoplasms
Increased effects of 2,5-dimethylcelecoxib on sensitivity of hepatocellular carcinoma cells to sorafenib via CYP3A5 expression and activation of AMPK.
Liver Neoplasms
Individuals having variant genotypes of cytochrome P450 2C19 are at increased risk of developing primary liver cancer in Han populations, without infection with the hepatitis virus.
Liver Neoplasms
Inhibition of calcitriol inactivating enzyme CYP24A1 gene expression by flavonoids in hepatocellular carcinoma cells under normoxia and hypoxia.
Liver Neoplasms
Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer.
Liver Neoplasms
Molecular basis of severe gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma.
Liver Neoplasms
N-Hydroxylation of 4-Aminobiphenyl by CYP2E1 Produces Oxidative Stress in a Mouse Model of Chemically Induced Liver Cancer.
Liver Neoplasms
Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway.
Liver Neoplasms
Pharmacological blockage of CYP2E1 and alcohol-mediated liver cancer: is the time ready?
Liver Neoplasms
Potential role of gut microbiota, the proto-oncogene PIKE (Agap2) and cytochrome P450 CYP2W1 in promotion of liver cancer by alcoholic and nonalcoholic fatty liver disease and protection by dietary soy protein.
Liver Neoplasms
Role of iron in alcoholic liver disease: introduction and summary of the symposium.
Liver Neoplasms
STAT3 & Cytochrome P450 2C9: a novel signaling pathway in liver cancer stem cells.
Liver Neoplasms
Sulfated extract of Abelmoschus esculentus: A potential cancer chemopreventive agent.
Liver Neoplasms
The effect of serum from liver cancer patients on the growth and function of primary and immortalised hepatocytes.
Liver Neoplasms
The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis.
Liver Neoplasms
The regulation mechanism of AhR activated by benzo[a]pyrene for CYP expression are different between 2D and 3D culture of human lung cancer cells.
Liver Neoplasms
The ubiquitin-proteasome 26s pathway in liver cell protein turnover: effect of ethanol and drugs.
Liver Neoplasms
Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines.
Liver Neoplasms
[Inhibitory effect of ellipticine (dimethyl-5,11-(6H) pyrido (4,3-b) carbazole on the induction of liver cancer by BT6 (N,N-dimethyl-p-(benzothiazolylazo) analine) and its effect on the levels of cytochrome P450 and arginase activity]
Liver Neoplasms
[Liver Tissue-specific Genes IGFALS,CYP3A4,SLC22A1 and CYP2E1 May be Associated with Poor Prognosis of Liver Cancer].
Liver Neoplasms, Experimental
Microsomal monooxygenase system in Morris hepatoma: purification and characterization of cytochromes P-450 from Morris hepatoma 5123D of 3-methylcholanthrene-treated rats.
Liver Neoplasms, Experimental
Properties of aryl hydrocarbon hydroxylase in microsomes of Morris hepatoma 5123D and the host liver.
Long QT Syndrome
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Low Tension Glaucoma
Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis.
Lung Diseases
Analyses of bronchial bulky DNA adduct levels and CYP2C9, GSTP1 and NQO1 genotypes in a Hungarian study population with pulmonary diseases.
Lung Diseases
Comparison of pulmonary DNA adduct levels, measured by 32P-postlabelling and aryl hydrocarbon hydroxylase activity in lung parenchyma of smokers and ex-smokers.
Lung Diseases
CYP1B1 genotype and risk of cardiovascular disease, pulmonary disease, and cancer in 50,000 individuals.
Lung Diseases
Decreased Cyp2E1 mRNA expression in human leucocytes in patients with fibrotic and inflammatory lung diseases.
Lung Diseases
Differential effects of the particle core and organic extract of diesel exhaust particles.
Lung Diseases
Hyperoxia-induced changes in estradiol metabolism in postnatal airway smooth muscle.
Lung Diseases
Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population.
Lung Diseases
Polymorphism in CYP1A1 and CYP2D6 genes: possible association with susceptibility to lung cancer.
Lung Diseases
The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finnish study population.
Lung Diseases
[Study on the association between genetic polymorphism of CYP2E1, GSTM1 and susceptibility of lung cancer.]
Lung Diseases, Interstitial
Cytochrome P450 polymorphisms and drug-induced interstitial lung disease.
Lung Diseases, Interstitial
Exacerbation of benzene pneumotoxicity in connexin 32 knockout mice: enhanced proliferation of CYP2E1-immunoreactive alveolar epithelial cells.
Lung Diseases, Interstitial
Gefitinib: new preparation. Non small-cell lung cancer: stricter assessment needed.
Lung Diseases, Interstitial
Relationship between drug-induced interstitial lung diseases and cytochrome P450 polymorphisms.
Lung Diseases, Obstructive
Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls.
Lung Diseases, Obstructive
[The CYP1B1 and CYP2F1 genes polymorphisms frequency in three ethnic groups of Bashkortostan and chronic obstructive pulmonary disease patients]
Lung Injury
?-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice.
Lung Injury
Apoptosis and Bax expression are increased by coal dust in the polycyclic aromatic hydrocarbon-exposed lung.
Lung Injury
Aryl hydrocarbon receptor is necessary to protect fetal human pulmonary microvascular endothelial cells against hyperoxic injury: Mechanistic roles of antioxidant enzymes and RelB.
Lung Injury
Attenuation of oxygen-induced abnormal lung maturation in rats by retinoic acid: possible role of cytochrome P4501A enzymes.
Lung Injury
Augmented oxygen-mediated transcriptional activation of cytochrome P450 (CYP)1A expression and increased susceptibilities to hyperoxic lung injury in transgenic mice carrying the human CYP1A1 or mouse 1A2 promoter in vivo.
Lung Injury
Comparison of the arachidonic acid and NADPH-dependent microsomal metabolism of naphthalene and 2-methylnaphthalene and the effect of indomethacin on the bronchiolar necrosis.
Lung Injury
Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury.
Lung Injury
Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury.
Lung Injury
Ethanol metabolism, oxidative stress, and endoplasmic reticulum stress responses in the lungs of hepatic alcohol dehydrogenase deficient deer mice after chronic ethanol feeding.
Lung Injury
Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice.
Lung Injury
Genetic polymorphisms in the cytochromes P-450 (1A1, 2E1), microsomal epoxide hydrolase and glutathione S-transferase M1, T1, and P1 genes, and their relationship with chronic bronchitis and relapsing pneumonia in children.
Lung Injury
High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4.
Lung Injury
Hyperoxia-mediated transcriptional activation of cytochrome P4501A1 (CYP1A1) and decreased susceptibility to oxygen-mediated lung injury in newborn mice.
Lung Injury
Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene.
Lung Injury
Knockout of cytochrome P450 1A1 enhances lipopolysaccharide-induced acute lung injury in mice by targeting NF-?B activation.
Lung Injury
Lung injury induced by pyrrolizidine alkaloids depends on metabolism by hepatic cytochrome P450s and blood transport of reactive metabolites.
Lung Injury
Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury.
Lung Injury
Mice Deficient in the Gene for Cytochrome P450 (CYP)1A1 Are More Susceptible Than Wild-Type to Hyperoxic Lung Injury: Evidence for Protective Role of CYP1A1 Against Oxidative Stress.
Lung Injury
Mice Lacking the Cytochrome P450 1B1 Gene Are Less Susceptible to Hyperoxic Lung Injury Than Wild Type.
Lung Injury
Modulation of Pulmonary Cytochrome P4501A1 Expression by Hyperoxia and Inhaled Nitric Oxide in the Newborn Rat: Implications for Lung Injury.
Lung Injury
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
Lung Injury
Newborn mice lacking the gene for Cyp1a1 are more susceptible to oxygen-mediated lung injury, and are rescued by postnatal ?-napthoflavone (BNF) administration: Implications for bronchopulmonary dysplasia (BPD) in premature infants.
Lung Injury
Omeprazole attenuates hyperoxic injury in H441 cells via the aryl hydrocarbon receptor.
Lung Injury
Omeprazole Attenuates Hyperoxic Lung Injury in Mice via Aryl hydrocarbon Receptor Activation, and is Associated with Increased Expression of Cytochrome P4501A Enzymes.
Lung Injury
Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-inducer, beta-naphthoflavone (BNF), and differential sex-specific effects.
Lung Injury
Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole.
Lung Injury
Prenatal administration of the cytochrome P4501A inducer, ?-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: Implications for bronchopulmonary dysplasia (BPD) in premature infants.
Lung Injury
Regulation of cytochrome P4501A1 expression by hyperoxia in human lung cell lines: Implications for hyperoxic lung injury.
Lung Injury
Regulation of pulmonary and hepatic cytochrome P4501A expression in the rat by hyperoxia: implications for hyperoxic lung injury.
Lung Injury
Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome.
Lung Injury
Sex-specific differences in hyperoxic lung injury in mice: Role of cytochrome P450 (CYP)1A.
Lung Injury
Sheep lung cytochrome P4501A1 (CYP1A1): cDNA cloning and transcriptional regulation by oxygen tension.
Lung Injury
Toxic Acetaminophen Exposure Induces Distal Lung ER Stress, Proinflammatory Signaling, and Emphysematous Changes in the Adult Murine Lung.
Lung Injury
[The CYP1B1 and CYP2F1 genes polymorphisms frequency in three ethnic groups of Bashkortostan and chronic obstructive pulmonary disease patients]
Lung Neoplasms
11Beta-hydroxysteroid dehydrogenase 1 expression in squamous cell carcinomas of the head and neck.
Lung Neoplasms
A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.
Lung Neoplasms
A case-control study of cytochrome P450 1A1, glutathione S-transferase M1, cigarette smoking and lung cancer susceptibility (Massachusetts, United States)
Lung Neoplasms
A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population.
Lung Neoplasms
A possible role for dihydrodiol dehydrogenase in the formation of benzo[a]pyrene-DNA adducts in lung cancer cells and tumor tissues.
Lung Neoplasms
A race-specific genetic polymorphism in the CYP1A1 gene is not associated with lung cancer in African Americans.
Lung Neoplasms
A regulatory variant in CYP2E1 affects the risk of lung squamous cell carcinoma.
Lung Neoplasms
A specific African-American CYP1A1 polymorphism is associated with adenocarcinoma of the lung.
Lung Neoplasms
Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation.
Lung Neoplasms
Altered regulation of the cytochrome P4501A1 gene: novel inducer-independent gene expression in pulmonary carcinoma cell lines.
Lung Neoplasms
An Rsa I polymorphism in the CYP2E1 gene does not affect lung cancer risk in a Japanese population.
Lung Neoplasms
Analysis of CYP1A1 exon 7 polymorphisms by PCR-SSCP in a Brazilian population and description of two novel gene variations.
Lung Neoplasms
Analysis of CYP2D6 expression in human lung: implications for the association between CYP2D6 activity and susceptibility to lung cancer.
Lung Neoplasms
Analysis of cytochrome P450 2E1 genetic polymorphisms in relation to human lung cancer.
Lung Neoplasms
Antioxidant and antitumor efficacy of Luteolin, a dietary flavone on benzo(a)pyrene-induced experimental lung carcinogenesis.
Lung Neoplasms
Antiproliferative and antioxidant potential of beta-ionone against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
Lung Neoplasms
Aryl hydrocarbon hydroxylase activity in human lung tissue: in relation to cigarette smoking and lung cancer.
Lung Neoplasms
Aryl hydrocarbon hydroxylase activity in pulmonary alveolar macrophages and lymphocytes from lung cancer and noncancer patients: a correlation with family histories of cancer.
Lung Neoplasms
Aryl hydrocarbon hydroxylase activity in pulmonary macrophages and blood lymphocytes. Asbestos-exposed cigarette smokers with and without lung cancer.
Lung Neoplasms
Aryl hydrocarbon hydroxylase activity in pulmonary macrophages and lymphocytes from lung cancer and noncancer patients.
Lung Neoplasms
Aryl hydrocarbon hydroxylase in human bronchial epithelium and blood monocyte.
Lung Neoplasms
Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls.
Lung Neoplasms
Aryl hydrocarbon hydroxylase inducibility and lymphoblast formation in lung cancer patients.
Lung Neoplasms
Aryl hydrocarbon hydroxylase inducibility in lung cancer patients undergoing radiotherapy.
Lung Neoplasms
Assessment of cancer susceptibility in humans by use of genetic polymorphisms in carcinogen metabolism.
Lung Neoplasms
Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population.
Lung Neoplasms
Association between a cytochrome P450 CYPIA1 genotype and incidence of lung cancer.
Lung Neoplasms
Association between Cancer Risk and Drug Metabolizing Enzyme Gene (CYP2A6, CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1) Polymorphisms in Japanese Cases of Lung Cancer.
Lung Neoplasms
Association between CYP2A13 polymorphisms and lung cancer: A protocol for systematic review and meta-analysis.
Lung Neoplasms
Association between CYP2A6 genetic polymorphisms and lung cancer: a meta-analysis of case-control studies.
Lung Neoplasms
Association between CYP2E1 genetic polymorphisms and lung cancer risk: a meta-analysis.
Lung Neoplasms
Association between genetic polymorphisms of the cytochromes P-450 (1A1, 2D6, and 2E1) and the susceptibility to pancreatic cancer.
Lung Neoplasms
Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and glutathione S-transferase P1 and CYP1A1 polymorphisms.
Lung Neoplasms
Association Between Polymorphisms in COMT, PLCH1, and CYP17A1, and Non-Small-Cell Lung Cancer Risk in Chinese Nonsmokers.
Lung Neoplasms
Association between the combined effects of GSTM1 present/null and CYP1A1 MspI polymorphisms with lung cancer risk: an updated meta-analysis.
Lung Neoplasms
Association between the CYP1A1 gene polymorphism and susceptibility to emphysema and lung cancer.
Lung Neoplasms
Association Between the CYP1B1 Polymorphisms and Lung Cancer Risk: A Meta-Analysis.
Lung Neoplasms
Association between the CYP2E1 polymorphisms and lung cancer risk: a meta-analysis.
Lung Neoplasms
Association of aryl hydrocarbon receptor and cytochrome P4501B1 expressions in human non-small cell lung cancers.
Lung Neoplasms
Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma.
Lung Neoplasms
Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer.
Lung Neoplasms
Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of non-small cell lung cancer in Andhra Pradesh region of South India.
Lung Neoplasms
Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer.
Lung Neoplasms
Association of CYP1B1 Leu432Val Polymorphism and Lung Cancer Risk: An Updated Meta-Analysis.
Lung Neoplasms
Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study.
Lung Neoplasms
Association of CYP2A6*4 with susceptibility of lung cancer: a meta-analysis.
Lung Neoplasms
Association of CYP2E1 and NAT2 polymorphisms with lung cancer susceptibility among Mongolian and Han populations in the Inner Mongolian region.
Lung Neoplasms
Association of CYP3A4, CYP3A5 polymorphisms with lung cancer risk in Bangladeshi population.
Lung Neoplasms
Association of functionally important polymorphisms in cytochrome P4501B1 with lung cancer.
Lung Neoplasms
Association of genetic polymorphisms CYP2A6*2 rs1801272 and CYP2A6*9 rs28399433 with tobacco-induced lung Cancer: case-control study in an Egyptian population.
Lung Neoplasms
Association of Ile462Val (Exon 7) polymorphism of cytochrome P450 IA1 with lung cancer in the Asian population: further evidence from a case-control study in Okinawa.
Lung Neoplasms
Association of the G134A and G184C Polymorphisms in the CYP1A1 Gene with Lung Cancer Incidence.
Lung Neoplasms
Associations between cytochrome P4502E1 genotype, mutagen sensitivity, cigarette smoking and susceptibility to lung cancer.
Lung Neoplasms
Associations of CYP1A1, GSTM1 and GSTT1 Polymorphisms with Lung Cancer Susceptibility in a Northern Indian Population.
Lung Neoplasms
Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens.
Lung Neoplasms
Associations of CYP1A2 Polymorphisms with the Risk Haplotypes in Lung Cancer in the Slovak Population.
Lung Neoplasms
Benzylmorpholine Analogs as Selective Inhibitors of Lung Cytochrome P450 2A13 for the Chemoprevention of Lung Cancer in Tobacco Users.
Lung Neoplasms
Carcinogen-induced tissue vitamin A depletion. Potential protective advantages of beta-carotene.
Lung Neoplasms
Cell type-specific differences in metabolic activation of N-nitrosodiethylamine by human lung cancer cell lines.
Lung Neoplasms
Changes in aromatase (CYP19) gene promoter usage in non-small cell lung cancer.
Lung Neoplasms
Characterization of common CYP1B1 variants with different capacity for benzo[a]pyrene-7,8-dihydrodiol epoxide formation from benzo[a]pyrene.
Lung Neoplasms
Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers.
Lung Neoplasms
Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq.
Lung Neoplasms
Chemopreventive effect of piperine on mitochondrial TCA cycle and phase-I and glutathione-metabolizing enzymes in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice.
Lung Neoplasms
Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1.
Lung Neoplasms
Combinations of cytochrome P-450 genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study.
Lung Neoplasms
Combinations of the Variant Genotypes of CYP1A1, GSTM1 and GSTT1 are Associated with an Increased Lung Cancer Risk in North Indian Population: a Case-Control Study.
Lung Neoplasms
Combined CYP1A1/GSTM1 at-risk genotypes are overrepresented in squamous cell lung carcinoma patients but underrepresented in elderly tumor-free subjects.
Lung Neoplasms
Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer.
Lung Neoplasms
Combined effect of GSTM1, GSTT1 and GSTP1 polymorphisms on histological subtypes of lung cancer.
Lung Neoplasms
Combined effects of CYP1A1 MspI and GSTM1 genetic polymorphisms on risk of lung cancer: an updated meta-analysis.
Lung Neoplasms
Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility.
Lung Neoplasms
Combined effects of serum trace metals and polymorphisms of CYP1A1 or GSTM1 on non-small cell lung cancer: A hospital based case-control study in China.
Lung Neoplasms
Comparison of cytochrome P450 2A6 polymorphism frequencies in Caucasians and African-Americans using a new one-step PCR-RFLP genotyping method.
Lung Neoplasms
Comparison of pulmonary DNA adduct levels, measured by 32P-postlabelling and aryl hydrocarbon hydroxylase activity in lung parenchyma of smokers and ex-smokers.
Lung Neoplasms
Concomitant occurence of multiple autoantibodies against human cytochromes P450.
Lung Neoplasms
Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR.
Lung Neoplasms
Correlation between gene polymorphisms of CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 and susceptibility to lung cancer.
Lung Neoplasms
Correlation between lung cancer prevalence and activities of aryl hydrocarbon hydroxylase and glutathione S-transferase in human lung tissues.
Lung Neoplasms
Correlation between P450 CYP1A1 inducibility, MspI genotype and lung cancer incidence.
Lung Neoplasms
Correlation of CYP1A1, GSTP1 and GSTM1 gene polymorphisms and lung cancer risk among smokers.
Lung Neoplasms
Correlation of inducibility of aryl hydrocarbon hydroxylase with susceptibility to 3-methylcholanthrene-induced lung cancers.
Lung Neoplasms
Current evidence on the relationship between CYP1B1 polymorphisms and lung cancer risk: a meta-analysis.
Lung Neoplasms
Current evidence on the relationship between three polymorphisms in the CYP1A2 gene and the risk of cancer.
Lung Neoplasms
CYP 1A1 polymorphism and risk of lung cancer in relation to tobacco smoking: a case-control study in China.
Lung Neoplasms
CYP 450 polymorphisms as risk factors for early onset lung cancer: gender specific differences.
Lung Neoplasms
CYP1A1 *2B and *4 polymorphisms are associated with lung cancer susceptibility in Mexican patients.
Lung Neoplasms
CYP1A1 and CYP1B1 Polymorphism and Lung Cancer Risk in Relation to Tobacco Smoking.
Lung Neoplasms
CYP1A1 and CYP1B1 polymorphisms and risk of lung cancer among never smokers: a population-based study.
Lung Neoplasms
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
Lung Neoplasms
CYP1A1 and CYP2D6 polymorphism and risk of lung cancer in a North Indian population.
Lung Neoplasms
CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro, Brazil.
Lung Neoplasms
CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis.
Lung Neoplasms
CYP1A1 and GSTM1 genetic polymorphisms in lung cancer populations exposed to arsenic in drinking water.
Lung Neoplasms
CYP1A1 and GSTM1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis.
Lung Neoplasms
CYP1A1 and GSTM1 polymorphisms in relation to lung cancer risk in Chinese women.
Lung Neoplasms
CYP1A1 exon7 polymorphism is associated with lung cancer risk among the female population and among smokers: a meta-analysis.
Lung Neoplasms
CYP1A1 gene polymorphisms and smoking status as modifier factors for lung cancer risk.
Lung Neoplasms
CYP1A1 gene polymorphisms increase lung cancer risk in a high-incidence region of Spain: a case control study.
Lung Neoplasms
CYP1A1 genetic polymorphisms, tobacco smoking and lung cancer risk in a French Caucasian population.
Lung Neoplasms
CYP1A1 genotype-selective inhibition of benzo[a]pyrene activation by quercetin.
Lung Neoplasms
CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Shanghai, China.
Lung Neoplasms
CYP1A1 I462V polymorphism is associated with reduced genotoxicity in yeast despite positive association with increased cancer risk.
Lung Neoplasms
CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer: a meta-analysis based on 32 studies.
Lung Neoplasms
CYP1A1 Ile462Val polymorphism and the risk of non-small cell lung cancer in a Chinese population.
Lung Neoplasms
CYP1A1 Ile462Val Polymorphism Contributes to Lung Cancer Susceptibility among Lung Squamous Carcinoma and Smokers: A Meta-Analysis.
Lung Neoplasms
CYP1A1 levels in lung tissue of tobacco smokers and polymorphisms of CYP1A1 and aromatic hydrocarbon receptor.
Lung Neoplasms
CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndromes patients.
Lung Neoplasms
CYP1A1 MspI and exon7 gene polymorphisms and lung cancer risk: an updated meta-analysis and review.
Lung Neoplasms
CYP1A1 MspI polymorphism and susceptibility to lung cancer in the Chinese population: an updated meta-analysis and review.
Lung Neoplasms
CYP1A1 MspI polymorphisms and lung cancer risk: an updated meta-analysis involving 20,209 subjects.
Lung Neoplasms
CYP1A1 polymorphisms and risk of lung cancer in non-smoking Chinese women: influence of environmental tobacco smoke exposure and GSTM1/T1 genetic variation.
Lung Neoplasms
CYP1A1 Polymorphisms and Risk of Lung Cancer in the Ethnic Kashmiri Population.
Lung Neoplasms
CYP1A1 T3801 C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controls.
Lung Neoplasms
CYP1A1 variants and smoking-related lung cancer in San Francisco Bay area Latinos and African Americans.
Lung Neoplasms
CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people.
Lung Neoplasms
CYP1A1, GSTM1 and GSTT1 polymorphisms and lung cancer: a pooled analysis of gene-gene interactions.
Lung Neoplasms
CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations.
Lung Neoplasms
CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratification.
Lung Neoplasms
CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population.
Lung Neoplasms
CYP1A2 rs2069514 polymorphism and lung cancer susceptibility: a meta-analysis.
Lung Neoplasms
CYP1A2 rs762551 polymorphism contributes to risk of lung cancer: A meta-analysis.
Lung Neoplasms
CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women.
Lung Neoplasms
CYP2A6 deletion polymorphism is associated with decreased susceptibility of lung cancer in Asian smokers: a meta-analysis.
Lung Neoplasms
CYP2A6 genetic polymorphism is associated with decreased susceptibility to squamous cell lung cancer in Japanese smokers.
Lung Neoplasms
CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study.
Lung Neoplasms
CYP2A6 Genotype and Smoking Behavior in Current Smokers Screened for Lung Cancer.
Lung Neoplasms
CYP2A6 overexpression in human lung cancers correlates with a high malignant status.
Lung Neoplasms
CYP2A6 polymorphism reveals differences in Japan and the existence of a specific variant in Ovambo and Turk populations.
Lung Neoplasms
CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers--findings from two independent populations.
Lung Neoplasms
CYP2A6, CYP1A1, and CYP2D6 polymorphisms in lung cancer patients from Central South China.
Lung Neoplasms
CYP2D6 gene polymorphism in caucasian smokers: lung cancer susceptibility and phenotype-genotype relationships.
Lung Neoplasms
CYP2D6 genotype and lung cancer risk according to histologic type and tobacco exposure.
Lung Neoplasms
CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles.
Lung Neoplasms
CYP2D6 T188C variant is associated with lung cancer risk in the Chinese population.
Lung Neoplasms
CYP2E1 and GSTM1 gene polymorphisms, environmental factors, and the susceptibility to lung cancer.
Lung Neoplasms
CYP2E1 polymorphism, cigarette smoking, p53 expression, and survival in non-small cell lung cancer: a long term follow-up study.
Lung Neoplasms
CYP2E1 rs2031920, COMT rs4680 Polymorphisms, Cigarette Smoking, Alcohol Use and Lung Cancer Risk in a Japanese Population.
Lung Neoplasms
CYP2E1 Rsa ?/Pst ? polymorphism and lung cancer susceptibility: a meta-analysis involving 10,947 subjects.
Lung Neoplasms
CYP2E1 Rsa ?/Pst ? polymorphism and lung cancer susceptibility: A meta-analysis involving 10,947 subjects.
Lung Neoplasms
CYP2E1 Rsa I/Pst I polymorphism is associated with lung cancer risk among Asians.
Lung Neoplasms
CYP4F2 and CYP3A5 gene polymorphisms and lung cancer in Chinese Han population.
Lung Neoplasms
Cytochrome P450 1A1 exon 7 polymorphism and susceptibility to lung cancer in the Chinese population: an updated meta-analysis and review.
Lung Neoplasms
Cytochrome P450 1A1 MspI polymorphism and urinary 1-hydroxypyrene concentrations in coke-oven workers.
Lung Neoplasms
Cytochrome P450 1B1 (CYP1B1) polymorphisms are associated with clinical outcome of docetaxel in non-small cell lung cancer (NSCLC) patients.
Lung Neoplasms
Cytochrome P450 2A isoenzymes in freshly prepared blood lymphocytes isolated from rats and validation as a biomarker for clinical studies in humans.
Lung Neoplasms
Cytochrome P450 2A6 deletion polymorphism and risk of lung cancer: a meta-analysis.
Lung Neoplasms
Cytochrome P450 2A6 whole-gene deletion (CYP2A6*4) polymorphism reduces risk of lung cancer: A meta-analysis.
Lung Neoplasms
Cytochrome P450 2E1 DraI polymorphisms in lung cancer in minority populations.
Lung Neoplasms
Cytochrome P450 2E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation.
Lung Neoplasms
Cytochrome P450 2E1 RsaI/PstI and DraI Polymorphisms Are Risk Factors for Lung Cancer in Mongolian and Han Population in Inner Mongolia.
Lung Neoplasms
Cytochrome P450 ?-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer.
Lung Neoplasms
Cytochrome P450 Allele CYP3A7*1C Associates with Adverse Outcomes in Chronic Lymphocytic Leukemia, Breast, and Lung Cancer.
Lung Neoplasms
Cytochrome P450 CYP2D6 gene polymorphism and lung cancer susceptibility in Caucasians.
Lung Neoplasms
Cytochrome P450 in non-small cell lung cancer related to exogenous chemical metabolism.
Lung Neoplasms
Cytochrome P450-isoenzyme 1A1 in susceptibility to tobacco-related lung cancer.
Lung Neoplasms
Cytochrome P4501A2 (CYP1A2) activity and lung cancer risk: a preliminary study among Chinese women in Singapore.
Lung Neoplasms
Cytochrome P4502C9 genotype in Southeast Anatolia and possible relation with some serum tumour markers and cytokines.
Lung Neoplasms
Cytochrome P4502E1 genetic polymorphisms and lung cancer in a Taiwanese population.
Lung Neoplasms
Cytotoxicity and genotoxicity of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol in CYP1A1-expressing human fibroblasts quantitatively correlate with CYP1A1 expression level.
Lung Neoplasms
Detection of CYP1A1 gene polymorphism using designed RFLP and distributions of CYP1A1 genotypes in Japanese.
Lung Neoplasms
Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes.
Lung Neoplasms
Determinants of Gefitinib toxicity in advanced non-small cell lung cancer (NSCLC): a pharmacogenomic study of metabolic enzymes and transporters.
Lung Neoplasms
Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.
Lung Neoplasms
Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes.
Lung Neoplasms
Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility--a review.
Lung Neoplasms
Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk.
Lung Neoplasms
Differences in Toxicological and Pharmacological Responses Mediated by Polymorphic Cytochromes P450 and Related Drug-Metabolizing Enzymes.
Lung Neoplasms
Differential Distribution of CYP2A6 and CYP2A13 in the Human Respiratory Tract.
Lung Neoplasms
Direct genotyping of Cytochrome P450 2A6 whole gene deletion from human blood samples by the SmartAmp method.
Lung Neoplasms
Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: A focus on nicotinic receptors and nicotine metabolizing enzyme.
Lung Neoplasms
Dissociation between aryl hydrocarbon hydroxylase activity in cultured pulmonary macrophages and blood lymphocytes from lung cancer patients.
Lung Neoplasms
DNA haplotype dependency of debrisoquine 4-hydroxylase (CYP2D6) expression among extensive metabolisers.
Lung Neoplasms
DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung.
Lung Neoplasms
Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients.
Lung Neoplasms
Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption.
Lung Neoplasms
Early changes in gene expression induced by tobacco smoke: Evidence for the importance of estrogen within lung tissue.
Lung Neoplasms
Effect of combined genetic polymorphisms on lung cancer risk in northern Thai women.
Lung Neoplasms
Effect of CYP1A1 MSPI Polymorphism on the Relationship Between TP53 Mutation and CDKN2A Hypermethylation in Non-small Cell Lung Cancer.
Lung Neoplasms
Effect of transforming growth factor-beta1 on expression of aryl hydrocarbon receptor and genes of Ah gene battery: clues for independent down-regulation in A549 cells.
Lung Neoplasms
Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers.
Lung Neoplasms
Effects of CYP3A5 genetic polymorphism and smoking on the prognosis of non-small-cell lung cancer.
Lung Neoplasms
Environmental factors and aryl hydrocarbon hydroxylase activity (CYP1A1 phenotype) in human lymphocytes.
Lung Neoplasms
Environmental tobacco smoke, genetic susceptibility, and risk of lung cancer in never-smoking women.
Lung Neoplasms
Erlotinib treatment induces cytochrome P450 3A activity in non-small cell lung cancer patients.
Lung Neoplasms
Estrogen receptor alpha promotes smoking-carcinogen-induced lung carcinogenesis via cytochrome P450 1B1.
Lung Neoplasms
Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol.
Lung Neoplasms
Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/Nrf2 pathway.
Lung Neoplasms
Ethnic susceptibility to lung cancer: differences in CYP2E1, CYP1A1 and GSTM1 genetic polymorphisms between French Caucasian and Chilean populations.
Lung Neoplasms
Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers.
Lung Neoplasms
Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients.
Lung Neoplasms
Evidence of gene gene interactions in lung carcinogenesis in a large pooled analysis.
Lung Neoplasms
Evidence-based prevention (EBP): A review of cytochrome P450 expression in the bronchial epithelium and new approach to lung cancer prevention.
Lung Neoplasms
Evidence-based prevention (EBP): approach to lung cancer prevention based on cytochrome 1A1 and cytochrome 2E1 polymorphism.
Lung Neoplasms
Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer.
Lung Neoplasms
Expression of aromatase CYP19 and its relationship with parameters in NSCLC.
Lung Neoplasms
Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas.
Lung Neoplasms
Expression of cytochrome P450 2A13 in human non-small cell lung cancer and its clinical significance.
Lung Neoplasms
Expression of pulmonary cytochrome P4501A1 and carcinogen DNA adduct formation in high risk subjects for tobacco-related lung cancer.
Lung Neoplasms
Finding Genes Discriminating Smokers from Non-smokers by Applying a Growing Self-organizing Clustering Method to Large Airway Epithelium Cell Microarray Data.
Lung Neoplasms
Four polymorphisms in the cytochrome P450 1A2 (CYP1A2) gene and lung cancer risk: a meta-analysis.
Lung Neoplasms
Frequencies of poor metabolizers of cytochrome P450 2C19 in esophagus cancer, stomach cancer, lung cancer and bladder cancer in Chinese population.
Lung Neoplasms
Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population.
Lung Neoplasms
Functional characterization of the human CYP1A1 negative regulatory element: modulation of Ah receptor mediated transcriptional activity.
Lung Neoplasms
Functionally active duplications of the CYP2D6 gene are more prevalent among larynx and lung cancer patients.
Lung Neoplasms
Gefitinib: new preparation. Non small-cell lung cancer: stricter assessment needed.
Lung Neoplasms
Gene polymorphism of cytochrome P450 significantly affects lung cancer susceptibility.
Lung Neoplasms
Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone.
Lung Neoplasms
Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in non-small cell lung cancer.
Lung Neoplasms
Genetic cancer susceptibility and DNA adducts: studies in smokers, tobacco chewers, and coke oven workers.
Lung Neoplasms
Genetic determinants of CYP2A6 activity across racial/ethnic groups with different risks of lung cancer and effect on their smoking intensity.
Lung Neoplasms
Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai cohort study.
Lung Neoplasms
Genetic Mutation of p53 and Suppression of the miR-17?92 Cluster Are Synthetic Lethal in Non-Small Cell Lung Cancer due to Upregulation of Vitamin D Signaling.
Lung Neoplasms
Genetic Polymorphism of CYP2A6 and Its Relationship with Nicotine Metabolism in Male Bataknese Smokers Suffered from Lung Cancer in Indonesia.
Lung Neoplasms
Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk.
Lung Neoplasms
Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers.
Lung Neoplasms
Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County.
Lung Neoplasms
Genetic polymorphism of cytochrome P4502E1 in a Swedish population. Relationship to incidence of lung cancer.
Lung Neoplasms
Genetic polymorphism of cytochromes P450 1A1, 2D6 and 2E1: regulation and toxicological significance.
Lung Neoplasms
Genetic polymorphism of cytochromes P450: interethnic differences and relationship to incidence of lung cancer.
Lung Neoplasms
Genetic polymorphism of the CYP1A1, CYP2E1, GSTM1 and GSTT1 genes and lung cancer susceptibility in a north indian population.
Lung Neoplasms
Genetic polymorphism of xenobiotic metabolising enzymes in Slovenian lung cancer patients.
Lung Neoplasms
Genetic polymorphism of xenobiotic metabolizing enzymes among Chinese lung cancer patients.
Lung Neoplasms
Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1 metabolic genes and risk of lung cancer in Asturias.
Lung Neoplasms
Genetic polymorphisms in CYP1B1, GSTA1, NQO1 and NAT2 and the risk of lung cancer.
Lung Neoplasms
Genetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene: implications for interindividual differences in nicotine metabolism.
Lung Neoplasms
Genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes and lung cancer risk.
Lung Neoplasms
Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population.
Lung Neoplasms
Genetic polymorphisms of drug-metabolizing enzymes and lung cancer susceptibility.
Lung Neoplasms
Genetic polymorphisms of human cytochrome P450 CYP1A1 in an Egyptian population and tobacco-induced lung cancer.
Lung Neoplasms
Genetic polymorphisms of NAD(P)H quinone oxidoreductase, CYP1A1 and microsomal epoxide hydrolase and lung cancer risk in Nanjing, China.
Lung Neoplasms
Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies.
Lung Neoplasms
Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers.
Lung Neoplasms
Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: a study on host factors in relation to age at onset, gender and histological cancer types.
Lung Neoplasms
Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior.
Lung Neoplasms
Genotyping of the CYP2D6 gene in Norwegian lung cancer patients and controls.
Lung Neoplasms
Genotyping of wild-type cytochrome P450 2A6 and whole-gene deletion using human blood samples and a multiplex real-time polymerase chain reaction method with dual-labeled probes.
Lung Neoplasms
Germ line polymorphisms of p53 and CYP1A1 genes involved in human lung cancer.
Lung Neoplasms
GSTM1 and CYP1A1 Polymorphisms, Tobacco, Air Pollution, and Lung Cancer: A Study in Rural Thailand.
Lung Neoplasms
GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms in lung cancer patients from an environmentally polluted region of Poland: correlation with lung DNA adduct levels.
Lung Neoplasms
Haplotypes in the 5'-untranslated region of the CYP1A2 gene are inversely associated with lung cancer risk but do not correlate with caffeine metabolism.
Lung Neoplasms
Human CYP1A1 (cytochrome P(1)450) gene: lack of association between the Msp I restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population.
Lung Neoplasms
Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls.
Lung Neoplasms
Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo.
Lung Neoplasms
Human lung microsomal cytochrome P4501A1 (CYP1A1) activities: impact of smoking status and CYP1A1, aryl hydrocarbon receptor, and glutathione S-transferase M1 genetic polymorphisms.
Lung Neoplasms
Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism.
Lung Neoplasms
Immunohistochemical detection of pulmonary cytochrome P450IA and metabolic activities associated with P450IA1 and P450IA2 isozymes in lung cancer patients.
Lung Neoplasms
In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility.
Lung Neoplasms
Increased expression of cytochrome P4501B1 in peripheral leukocytes from lung cancer patients.
Lung Neoplasms
Induction of cytochrome P450 3A4 by docetaxel in peripheral mononuclear cells and its expression in lung cancer.
Lung Neoplasms
Influence of a mutation reducing the catalytic activity of the cytochrome P450 CYP2D6 on lung cancer susceptibility.
Lung Neoplasms
Influence of antioxidants and the CYP1A1 isoleucine to valine polymorphism on the smoking--lung cancer association.
Lung Neoplasms
Influence of CYP1A1, GSTM1, GSTT1, and NQO1 genotypes and cumulative smoking dose on lung cancer risk in a Swedish population.
Lung Neoplasms
Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans.
Lung Neoplasms
Influence of polymorphism at p53, CYP1A1 and GSTM1 loci on p53 mutation and association of p53 mutation with prognosis in lung cancer.
Lung Neoplasms
Interaction between CYP1A2-T2467DELT polymorphism and smoking in adenocarcinoma and squamous cell carcinoma of the lung.
Lung Neoplasms
Interaction between dose and susceptibility to environmental cancer: a short review.
Lung Neoplasms
Interaction of CYP1B1, cigarette-smoke carcinogen metabolism, and lung cancer risk.
Lung Neoplasms
Interaction of cytochrome P4501A1 genotypes with other risk factors and susceptibility to lung cancer.
Lung Neoplasms
Interaction of the CYP1A1 gene polymorphism and smoking in non-small cell lung cancer susceptibility.
Lung Neoplasms
Interactions between cytotoxic chemotherapy and antiretroviral treatment in human immunodeficiency virus-infected patients with lung cancer.
Lung Neoplasms
Interactions between detoxifying enzyme polymorphisms and susceptibility to cancer.
Lung Neoplasms
Interactions between genetic predisposition and environmental toxicants for development of lung cancer.
Lung Neoplasms
Interactive effect of genetic polymorphism of glutathione S-transferase M1 and smoking on squamous cell lung cancer risk in Korea.
Lung Neoplasms
Interactive potential of genetic polymorphism in Xenobiotic metabolising and DNA repair genes for predicting lung cancer predisposition and overall survival in North Indians.
Lung Neoplasms
Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation.
Lung Neoplasms
Inverse association of vitamin D3 levels with lung cancer mediated by genetic variation.
Lung Neoplasms
Investigating the influence of relevant pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of orally administered docetaxel combined with ritonavir.
Lung Neoplasms
Lack of associations among cancer and albumin adducts, ras p21 oncoprotein levels, and CYP1A1, CYP2D6, NAT1, and NAT2 in a nested case-control study of lung cancer within the physicians' health study.
Lung Neoplasms
Large interindividual variations in metabolism of benzo(alpha)pyrene by peripheral lung tissue from lung cancer patients.
Lung Neoplasms
Localization of CYP1A1 mRNA in human lung by in situ hybridization: comparison with immunohistochemical findings.
Lung Neoplasms
Lung cancer and CYP2D6 (the debrisoquine polymorphism): sources of heterogeneity in the proposed association.
Lung Neoplasms
Lung cancer risk in African-Americans in relation to a race-specific CYP1A1 polymorphism.
Lung Neoplasms
Lung cancer risk in relation to nicotinic acetylcholine receptor, CYP2A6 and CYP1A1 genotypes in the Bangladeshi population.
Lung Neoplasms
Lung cancer risk in relation to the CYP2C9 genetic polymorphism among Caucasians in Los Angeles County.
Lung Neoplasms
Lung cancer risk in relation to the CYP2E1 Rsa I genetic polymorphism among African-Americans and Caucasians in Los Angeles County.
Lung Neoplasms
Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway.
Lung Neoplasms
MDR1 single nucleotide polymorphisms predict response to vinorelbine-based chemotherapy in patients with non-small cell lung cancer.
Lung Neoplasms
Meta-analysis of correlation between the CYP1A2 -3860 G > A polymorphism and lung cancer risk.
Lung Neoplasms
Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson's disease.
Lung Neoplasms
Metabolic cytochrome P450 genotypes and assessment of individual susceptibility to lung cancer.
Lung Neoplasms
Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation - a mammalian cell-based mutagenesis approach.
Lung Neoplasms
Metabolic gene polymorphisms and lung cancer risk in non-smokers An update of the GSEC study.
Lung Neoplasms
Metabolic Pathway of Icotinib In Vitro: The Differential Roles of CYP3A4, CYP3A5, and CYP1A2 on Potential Pharmacokinetic Drug-Drug Interaction.
Lung Neoplasms
Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans.
Lung Neoplasms
Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines.
Lung Neoplasms
Methodological issues in the interpretation of studies of the CYP2D6 genotype in relation to lung cancer risk.
Lung Neoplasms
MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer (NSCLC) through down-regulation of CYP1B1.
Lung Neoplasms
Mitogen-activated lymphocytes: a good model for characterising lung CYP1A1 inducibility.
Lung Neoplasms
Modulation of lung molecular biomarkers by beta-carotene in the Physicians' Health Study.
Lung Neoplasms
Molecular epidemiological study of non-small-cell lung cancer from an environmentally polluted region of Poland.
Lung Neoplasms
Molecular epidemiology: a new perspective for the study of toxic exposures in man. A consideration of the influence of genetic susceptibility factors on risk in different lung cancer histologies.
Lung Neoplasms
Molecular modeling of cytochrome P450 1A1: enzyme-substrate interactions and substrate binding affinities.
Lung Neoplasms
Mutant genes of cytochrome P-450IID6, glutathione S-transferase class Mu, and arylamine N-acetyltransferase in lung cancer patients.
Lung Neoplasms
NAT2 and CYP1A2 polymorphisms and lung cancer risk in relation to smoking status.
Lung Neoplasms
NAT2 fast acetylator genotype is associated with an increased risk of lung cancer among never-smoking women in Taiwan.
Lung Neoplasms
New opportunities in cancer risk evaluation using PCR-based DNA analysis for CYP2D6.
Lung Neoplasms
Nicotine Metabolism and Smoking: Ethnic Differences in the Role of P450 2A6.
Lung Neoplasms
Nicotine metabolism in three ethnic/racial groups with different risks of lung cancer.
Lung Neoplasms
Note of clarification of data on the association between CYP2E1 RsaI polymorphism and lung cancer risk.
Lung Neoplasms
Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.
Lung Neoplasms
Overexpression of cytochrome P450 1B1 in advanced non-small cell lung cancer: a potential therapeutic target.
Lung Neoplasms
p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated patients with non-small cell lung cancer.
Lung Neoplasms
p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms.
Lung Neoplasms
Particulate matter less than 10??m (PM10) activates cancer related genes in lung epithelial cells.
Lung Neoplasms
Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Lung Neoplasms
Pharmacogenetics of solid tumors: directed therapy in breast, lung, and colorectal cancer: a paper from the 2008 william beaumont hospital symposium on molecular pathology.
Lung Neoplasms
Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects.
Lung Neoplasms
Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics.
Lung Neoplasms
Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.
Lung Neoplasms
Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis.
Lung Neoplasms
Pleomorphic (giant and/or spindle cell) carcinoma of lung shows a high percentage of variant CYP1A12.
Lung Neoplasms
Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population.
Lung Neoplasms
Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2.
Lung Neoplasms
Polycyclic aromatic hydrocarbon-DNA adducts and the CYP1A1 restriction fragment length polymorphism.
Lung Neoplasms
Polycyclic aromatic hydrocarbon-DNA adducts in human placenta and modulation by CYP1A1 induction and genotype.
Lung Neoplasms
Polymorphic CYP genes and disease predisposition--what have the studies shown so far?
Lung Neoplasms
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Lung Neoplasms
Polymorphism analysis of the CYP1A1 locus in Koreans: presence of the solitary m2 allele.
Lung Neoplasms
Polymorphism in CYP1A1 and CYP2D6 genes: possible association with susceptibility to lung cancer.
Lung Neoplasms
Polymorphism in CYP24A1 Is Associated with Lung Cancer Risk: A Case-Control Study in Chinese Female Nonsmokers.
Lung Neoplasms
Polymorphism in cytochrome P450 1A2 and their interaction with risk factors in determining risk of squamous cell lung carcinoma in men.
Lung Neoplasms
Polymorphism of cytochrome p450, glutathione-s-transferase and N-acetyltransferases: influence on lung cancer susceptibility.
Lung Neoplasms
Polymorphism of metabolizing genes and lung cancer histology: prevalence of CYP2E1 in adenocarcinoma.
Lung Neoplasms
Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer.
Lung Neoplasms
Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients.
Lung Neoplasms
Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years.
Lung Neoplasms
Polymorphisms in GSTM1, CYP1A1, CYP2E1, and CYP2D6 are Associated with Susceptibility and Chemotherapy Response in Non-small-cell Lung Cancer Patients.
Lung Neoplasms
Polymorphisms in the human CYP1A1 gene as susceptibility factors for lung cancer: exon-7 mutation (4889 A to G), and a T to C mutation in the 3'-flanking region.
Lung Neoplasms
Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer.
Lung Neoplasms
Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.
Lung Neoplasms
Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population.
Lung Neoplasms
Polymorphisms of the GSTM1 and CYP2D6 genes associated with susceptibility to lung cancer in Chinese.
Lung Neoplasms
Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States).
Lung Neoplasms
Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes.
Lung Neoplasms
Possible risk modification by CYP1A1, GSTM1 and GSTT1 gene polymorphisms in lung cancer susceptibility in a South Indian population.
Lung Neoplasms
Potentially estrogenic polychlorinated biphenyls congeners serum levels and its relation with lung cancer.
Lung Neoplasms
Pregnane X receptors regulate CYP2C8 and P-glycoprotein to impact on the resistance of NSCLC cells to Taxol.
Lung Neoplasms
Profiling gene expression of whole cytochrome P450 superfamily in human bronchial and peripheral lung tissues: Differential expression in non-small cell lung cancers.
Lung Neoplasms
Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule.
Lung Neoplasms
Prognostic significance of germ line polymorphisms of the CYP1A1 and glutathione S-transferase genes in patients with non-small cell lung cancer.
Lung Neoplasms
Protease inhibitors exposure is not related to lung cancer risk in HIV smoker patients: a nested case-control study.
Lung Neoplasms
Pulmonary CYP2A13 levels are associated with early occurrence of lung cancer-Its implication in mutagenesis of non-small cell lung carcinoma.
Lung Neoplasms
Pulmonary drug-metabolizing enzyme in alveolar macrophages in relation to cigarette smoking.
Lung Neoplasms
Pulmonary expression of CYP2A13 and ABCB1 is regulated by FOXA2 and their genetic interaction is associated with lung cancer.
Lung Neoplasms
Rapid detection of single nucleotide polymorphisms related with lung cancer susceptibility of Chinese population.
Lung Neoplasms
Re: London,S.J. et al. (1997) Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County. Carcinogenesis, 18, 1203-1214.
Lung Neoplasms
Re: S. J. London et al., Lung cancer risk in African-Americans in relation to a race-specific CYP1A1 polymorphism. Cancer Res., 55: 6035-6037, 1995.
Lung Neoplasms
Reassessment of the relationship between aryl hydrocarbon hydroxylase and lung cancer.
Lung Neoplasms
Reduced CYP2D6 function is associated with gefitinib-induced rash in patients with non-small cell lung cancer.
Lung Neoplasms
Relation between inducibility of CYP1A1, GSTM1 and lung cancer in a French population.
Lung Neoplasms
Relationship between ambient air pollution and DNA damage in Polish mothers and newborns.
Lung Neoplasms
Relationship between CYP1B1 polymorphisms (c.142C > G, c.355G > T, c.1294C > G) and lung cancer risk in Polish smokers.
Lung Neoplasms
Relationship Between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 Variation and Smoking Behaviors and Lung Cancer Risk.
Lung Neoplasms
Relevance of metabolic polymorphisms to human carcinogenesis: evaluation of epidemiologic evidence.
Lung Neoplasms
Restriction fragment length polymorphism of the human CYP2E1 (cytochrome P450IIE1) gene and susceptibility to lung cancer: possible relevance to low smoking exposure.
Lung Neoplasms
Retraction: CYP1A2 rs2069514 polymorphism and lung cancer susceptibility: a meta-analysis.
Lung Neoplasms
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Lung Neoplasms
Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of environmental tobacco smoke and lung cancer: a case-control study in Japanese nonsmoking women.
Lung Neoplasms
Risk of non-small cell lung cancer and the cytochrome P4501A1 Ile462Val polymorphism.
Lung Neoplasms
Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population.
Lung Neoplasms
Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non-small-Cell Lung Cancer Receiving Erlotinib Treatment.
Lung Neoplasms
Role of estrogen receptor in regulation of polycyclic aromatic hydrocarbon metabolic activation in lung.
Lung Neoplasms
Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP.
Lung Neoplasms
Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers.
Lung Neoplasms
Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma.
Lung Neoplasms
Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytes.
Lung Neoplasms
Sex differences in lung CYP1A1 expression and DNA adduct levels among lung cancer patients.
Lung Neoplasms
Sex differences in risk of lung cancer: Expression of genes in the PAH bioactivation pathway in relation to smoking and bulky DNA adducts.
Lung Neoplasms
Smoking and peripheral type of cancer are related to high levels of pulmonary cytochrome P450IA in lung cancer patients.
Lung Neoplasms
Smoking habit and genetic factors associated with lung cancer in a population highly exposed to arsenic.
Lung Neoplasms
Smoking-associated bulky DNA adducts in bronchial tissue related to CYP1A1 MspI and GSTM1 genotypes in lung patients.
Lung Neoplasms
Structure and polymorphisms of human aryl hydrocarbon receptor repressor (AhRR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer.
Lung Neoplasms
Structure, Function, Regulation and Polymorphism of Human Cytochrome P450 2A6.
Lung Neoplasms
Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands.
Lung Neoplasms
Study design and genetic susceptibility factors in the risk assessment of chemical carcinogens.
Lung Neoplasms
Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK.
Lung Neoplasms
Susceptibility of lung cancer with polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 genotypes in the population of Inner Mongolia region.
Lung Neoplasms
Susceptibility to lung cancer and genetic polymorphisms in the alcohol metabolite-related enzymes alcohol dehydrogenase 3, aldehyde dehydrogenase 2, and cytochrome P450 2E1 in the Japanese population.
Lung Neoplasms
Susceptibility to lung cancer in light smokers associated with CYP1A1 polymorphisms in Mexican- and African-Americans.
Lung Neoplasms
Synergistic association of CYP1A1 polymorphisms with increased susceptibility to squamous cell lung cancer in north Indian smokers.
Lung Neoplasms
Synergistic association of PTGS2 and CYP2E1 genetic polymorphisms with lung cancer risk in northeastern Chinese.
Lung Neoplasms
Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer.
Lung Neoplasms
The correlation of combined OGG1, CYP1A1 and GSTP1 gene variants and risk of lung cancer of male Iraqi waterpipe tobacco smokers.
Lung Neoplasms
The CYP1B1 Leu432Val polymorphism contributes to lung cancer risk: Evidence from 6501 subjects.
Lung Neoplasms
The CYP3A4*1B allele increases risk for small cell lung cancer: effect of gender and smoking dose.
Lung Neoplasms
The cytochrome P450 enzyme CYP24A1 increases proliferation of mutant KRAS-dependent lung adenocarcinoma independently of its catalytic activity.
Lung Neoplasms
The effect of cigarette smoke on aryl hydrocarbon hydroxylase activity and cytochrome P450 content in rat liver and lung microsomes.
Lung Neoplasms
The effect of CYP1A1 polymorphisms on the risk of lung cancer: a global meta-analysis based on 71 case-control studies.
Lung Neoplasms
The effect of CYP1A1, GSTT1 and GSTM1 polymorphisms on the risk of lung cancer: A case-control study.
Lung Neoplasms
The Effect of Rifampin on the Pharmacokinetics and Safety of Lorlatinib: Results of a Phase One, Open-Label, Crossover Study in Healthy Participants.
Lung Neoplasms
The effects of quercetin on antioxidant status and tumor markers in the lung and serum of mice treated with benzo(a)pyrene.
Lung Neoplasms
The heme-binding region polymorphism of cytochrome P450IA1 (CypIA1), rather than the RsaI polymorphism of IIE1 (CypIIE1), is associated with lung cancer in Rio de Janeiro.
Lung Neoplasms
The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finnish study population.
Lung Neoplasms
The Impact of IL-16 3'UTR Polymorphism rs859 on Lung Carcinoma Susceptibility among Chinese Han Individuals.
Lung Neoplasms
The interaction between smoking and CYP1A1 MspI polymorphism on lung cancer: a meta-analysis in the Chinese population.
Lung Neoplasms
The polymorphism of CYP2E1 Rsa I/Pst I gene and susceptibility to respiratory system cancer: a systematic review and meta-analysis of 34 studies.
Lung Neoplasms
The regulation mechanism of AhR activated by benzo[a]pyrene for CYP expression are different between 2D and 3D culture of human lung cancer cells.
Lung Neoplasms
The relationship between aryl hydrocarbon hydroxylase activity and DNA adducts measured by (32)P-postlabelling assay in lymphocytes of lung cancer patients.
Lung Neoplasms
The relationship between CYP1A1 aryl hydrocarbon hydroxylase activity and lung cancer in a Japanese population.
Lung Neoplasms
The role of CYP1A1 Msp1 gene polymorphisms on lung cancer development in Turkey.
Lung Neoplasms
The sparteine/debrisoquine (CYP2D6) oxidation polymorphism and the risk of lung cancer: a meta-analysis.
Lung Neoplasms
Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women.
Lung Neoplasms
Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells.
Lung Neoplasms
Transplacental lung carcinogenesis: a pharmacogenetic mouse model for the modulatory role of cytochrome P450 1A1 on lung cancer initiation.
Lung Neoplasms
Treatment of lung cancer patients and concomitant use of drugs interacting with cytochrome P450 isoenzymes.
Lung Neoplasms
Updated meta-analysis of the association between CYP2E1 RsaI/PstI polymorphisms and lung cancer risk in Chinese population.
Lung Neoplasms
Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms.
Lung Neoplasms
Variation in CYP2A6 and nicotine metabolism among two American Indian tribal groups differing in smoking patterns and risk for tobacco-related cancer.
Lung Neoplasms
[A case control study on the impact of CYP450 MSPI and GST-M1 polymorphisms on the risk of lung cancer]
Lung Neoplasms
[A case-control study on the association between genetic polymorphisms of metabolizing enzymes CYP2D6 and susceptibility to lung cancer.]
Lung Neoplasms
[A case-control study on the impact of cytochrome P450 2E1 and 1A1 gene polymorphisms on the risk of lung can- cer of the Han nationality in Guangzhou district.]
Lung Neoplasms
[A role of aryl hydrocarbon hydroxylase inducibility in susceptibility to lung carcinogenesis]
Lung Neoplasms
[Allelic distribution of the CYP1A1 in lung cancer patients, middle-aged tissue donors and in elderly people without cancer]
Lung Neoplasms
[Application of molecular biology to occupational health field--the frequency of gene polymorphism of cytochrome P450 1A1 and glutathione S-transferase M1 in patients with lung, oral and urothelial cancer]
Lung Neoplasms
[Aryl hydrocarbon hydroxylase level as a possible risk indicator of susceptibility to lung cancer]
Lung Neoplasms
[Association of CYP1A1 Ile462Val polymorphisms with susceptibility to small cell lung cancer].
Lung Neoplasms
[Association of cytochrome P-450 1A1 (CYP1A1) gene polymorphism to smoking status and hematologic findings]
Lung Neoplasms
[Combined effects of genetic polymorphisms in cytochrome P450s and GSTM1 on lung cancer susceptibility]
Lung Neoplasms
[CYP1A1 Gene and GSTM1 Gene Polymorphism and the Combined Effects and Risk of Lung Cancer: A meta-analysis].
Lung Neoplasms
[CYP1A1 polymorphisms, lack of glutathione S-transferase M1 (GSTM1), cooking oil fumes and lung cancer risk in non-smoking women].
Lung Neoplasms
[Evidence based prevention (EBP): evidence-based approach to prevention of lung cancer by application of cytochrome 2E1 polymorphism]
Lung Neoplasms
[Frequency of CYP2A6 gene deletion and its relation to risk of lung cancer.]
Lung Neoplasms
[Genetic and phenotypic polymorphisms in carcinogen-metabolizing enzymes and cancer susceptibility]
Lung Neoplasms
[Genetic determination of aryl hydrocarbon hydroxylase activity and its significance in the etiology of lung cancer]
Lung Neoplasms
[Individual susceptibility to occupational carcinogens: the evidence from biomonitoring and molecular epidemiology studies]
Lung Neoplasms
[Metabolic polymorphisms and the cancer risk: the evaluation of epidemiological studies]
Lung Neoplasms
[Polymorphisms of the CYP1A1 and GSTM1 genes and their combined effects on individual susceptibility to lung cancer in a Chinese population]
Lung Neoplasms
[Preliminary study on the expression of aromatase P450 mRNA in human lung cancer tissues.]
Lung Neoplasms
[Relation between cytochrome P450 2D6 and lung cancer susceptibility caused by smoking]
Lung Neoplasms
[Relationship between CYP1A1 and GSTM1 genetic polymorphisms and lung cancer susceptibility in population of Inner Mongolia.]
Lung Neoplasms
[Relationship between genetic polymorphism of metabolizing enzymes and lung cancer susceptibility.]
Lung Neoplasms
[Role of ancestral genotypes of the genes of xenobiotics biotransformation in susceptibility to lung cancer among Mayak workers].
Lung Neoplasms
[Studies of the genes related to lung cancer susceptibility in Nanjing Han population, China.]
Lung Neoplasms
[Study on the association between genetic polymorphism of CYP2E1, GSTM1 and susceptibility of lung cancer.]
Lung Neoplasms
[Study on the relationship between polymorphisms of CYP1A1 gene and susceptibility of lung cancer in Sichuan population.]
Lung Neoplasms
[Susceptibility to bronchial cancer: an example of genetic-environmental interaction]
Lung Neoplasms
[Susceptibility to lung cancer in Chinese is associated with genetic polymorphism in cytochrome P4502E1]
Lung Neoplasms
[The relationship between genetic polymorphism of metabolizing enzymes and the genetic susceptibility to lung cancer]
Lung Neoplasms
[The strategic use of genetic polymorphisms in carcinogen metabolizing enzyme for prevention of cancer]
Lupus Erythematosus, Systemic
Association between Functional CYP2D6 Polymorphisms and Susceptibility to Autoimmune Diseases: A Meta-Analysis.
Lupus Erythematosus, Systemic
Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population.
Lupus Erythematosus, Systemic
Association of Polymorphisms of Cytochrome P450 2D6 With Blood Hydroxychloroquine Levels in Patients With Systemic Lupus Erythematosus.
Lupus Erythematosus, Systemic
Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Cyclophosphamide boluses induce micronuclei expression in buccal mucosa cells of patients with systemic lupus erythematosus independent of cytochrome P450 2D6 status.
Lupus Erythematosus, Systemic
CYP2D6 polymorphism in systemic lupus erythematosus patients.
Lupus Erythematosus, Systemic
Cytochrome P450 and manganese superoxide dismutase genes polymorphisms in systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Cytochrome P450 Polymorphism as a Predictor of Ovarian Toxicity to Pulse Cyclophosphamide in Systemic Lupus Erythematosus.
Lupus Erythematosus, Systemic
Cytochrome P450 polymorphism as a predictor of ovarian toxicity to pulse cyclophosphamide in systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Genetic analysis of the cytochrome P450 CYP2D6 polymorphism in patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Genetic markers in CYP2C19 and CYP2B6 for prediction of cyclophosphamide's 4-hydroxylation, efficacy and side effects in Chinese patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Genetic polymorphism of CYP2D6 in patients with systemic lupus erythematosus and systemic sclerosis.
Lupus Erythematosus, Systemic
Genetic polymorphisms of CYP2D6 oxidation in patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Genetic polymorphisms of glutathione S-transferases and cytochrome P450 enzymes as susceptibility factors to systemic lupus erythematosus in southern Brazilian patients.
Lupus Erythematosus, Systemic
Initial dose optimization of tacrolimus for children with systemic lupus erythematosus based on the CYP3A5 polymorphism and coadministration with Wuzhi capsule.
Lupus Erythematosus, Systemic
Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice.
Lupus Erythematosus, Systemic
Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of cigarette smoking and systemic lupus erythematosus in a Japanese population.
Lupus Erythematosus, Systemic
Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3.
Lupus Erythematosus, Systemic
Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population.
Lupus Erythematosus, Systemic
The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.
Lupus Nephritis
Analysis of cytochrome P450 gene polymorphism in a lupus nephritis patient in whom tacrolimus blood concentration was markedly elevated after administration of azole antifungal agents.
Lupus Nephritis
Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritis.
Lupus Nephritis
Cytochrome P450 polymorphisms and the response of lupus nephritis to cyclophosphamide therapy.
Lupus Nephritis
Effects of CYP3A5 polymorphism and the tacrolimus 12?h concentration on tacrolimus-induced acute renal dysfunction in patients with lupus nephritis.
Lupus Nephritis
Epistatic interactions among CYP2C19*2, CYP3A4 and GSTP1 on the cyclophosphamide therapy in lupus nephritis patients.
Lupus Nephritis
Use of Enantiomeric Bupropion and Hydroxybupropion to Assess CYP2B6 Activity in Glomerular Kidney Diseases.
Lymphadenitis
Antitumor effects and mechanisms of 1,25(OH)2D3 in the Pfeiffer diffuse large B lymphoma cell line.
Lymphatic Metastasis
Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors.
Lymphatic Metastasis
CYP24A1 is a potential biomarker for the progression and prognosis of human colorectal cancer.
Lymphatic Metastasis
CYP27A1 and CYP24 expression as a function of malignant transformation in the colon.
Lymphatic Metastasis
CYP2A6 overexpression in human lung cancers correlates with a high malignant status.
Lymphatic Metastasis
Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
Lymphatic Metastasis
Inflammatory breast cancer: Activation of the aryl hydrocarbon receptor and its target CYP1B1 correlates closely with Wnt5a/b-?-catenin signalling, the stem cell phenotype and disease progression.
Lymphatic Metastasis
miR-30a promoter variation contributes to the increased risk of colorectal cancer in an Iranian population.
Lymphatic Metastasis
Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study.
Lymphatic Metastasis
Prognostic value of using glucosylceramide synthase and cytochrome P450 family 1 subfamily A1 expression levels for patients with triple-negative breast cancer following neoadjuvant chemotherapy.
Lymphatic Metastasis
Vitamin D-neutralizing CYP24A1 expression, oncogenic mutation states and histological findings of human papillary thyroid cancer.
Lymphatic Metastasis
[Study on the Difference of Gene Expression between Central and Peripheral Lung Squamous Cell Carcinoma Based on TCGA Database].
Lymphedema
CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients?
Lymphoma
Cytochrome P450 2B6*5 Increases Relapse after Cyclophosphamide-Containing Conditioning and Autologous Transplantation for Lymphoma.
Lymphoma
Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.
Lymphoma
Effect of the Cytochrome P450 2C19 Inhibitor Omeprazole on the Pharmacokinetics and Safety Profile of Bortezomib in Patients with Advanced Solid Tumours, Non-Hodgkin's Lymphoma or Multiple Myeloma.
Lymphoma
Effects of Strong CYP2C8 or CYP3A Inhibition and CYP3A Induction on the Pharmacokinetics of Brigatinib, an Oral Anaplastic Lymphoma Kinase Inhibitor, in Healthy Volunteers.
Lymphoma
Expression of CYP3A4 as a predictor of response to chemotherapy in peripheral T-cell lymphomas.
Lymphoma
Genetic polymorphisms and vincristine-induced peripheral neuropathy in patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone therapy.
Lymphoma
Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas.
Lymphoma
Human bronchial epithelial cells exposed in vitro to diesel exhaust particles exhibit alterations in cell rheology and cytotoxicity associated with decrease in antioxidant defenses and imbalance in pro- and anti-apoptotic gene expression.
Lymphoma
Pien Tze Huang Gan Bao attenuates carbon tetrachloride?induced hepatocyte apoptosis in rats, associated with suppression of p53 activation and oxidative stress.
Lymphoma
Safety Evaluation of a Proprietary Food-Grade, Dried Fermentate Preparation of Saccharomyces cerevisiae.
Lymphoma
The Effect of Rifampin on the Pharmacokinetics and Safety of Lorlatinib: Results of a Phase One, Open-Label, Crossover Study in Healthy Participants.
Lymphoma
[Effect and mechanism of liraglutide on the apoptosis of human hepatocellular carcinoma HepG2 cells induced with palmitic acid].
Lymphoma
[Study on mesenchymal stem cells mediated enzyme-prodrug gene CYP1A2 targeting anti-tumor effect]
Lymphoma, B-Cell
Antioxidant, anti-inflammatory and anti-apoptotic effects of hydro-ethanolic extract of Cyperus esculentus L. (tigernut) on lead acetate-induced testicular dysfunction in Wistar rats.
Lymphoma, B-Cell
Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration.
Lymphoma, B-Cell
Genetic polymorphisms and vincristine-induced peripheral neuropathy in patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone therapy.
Lymphoma, B-Cell
Irbesartan mitigates acute liver injury, oxidative stress, and apoptosis induced by acetaminophen in mice.
Lymphoma, B-Cell
Polymorphisms of drug-metabolizing enzymes CYP1A1, GSTT and GSTP contribute to the development of diffuse large B-cell lymphoma risk in the Saudi Arabian population.
Lymphoma, B-Cell
Synthesis and Evaluation of Novel Cholestanoheterocyclic Steroids as Anticancer Agents.
Lymphoma, B-Cell
[Effect and mechanism of liraglutide on the apoptosis of human hepatocellular carcinoma HepG2 cells induced with palmitic acid].
Lymphoma, Follicular
Genetic polymorphisms in the metabolic pathway and non-Hodgkin lymphoma survival.
Lymphoma, Large B-Cell, Diffuse
Polymorphisms of drug-metabolizing enzymes CYP1A1, GSTT and GSTP contribute to the development of diffuse large B-cell lymphoma risk in the Saudi Arabian population.
Lymphoma, Mantle-Cell
Effect of the Cytochrome P450 2C19 Inhibitor Omeprazole on the Pharmacokinetics and Safety Profile of Bortezomib in Patients with Advanced Solid Tumours, Non-Hodgkin's Lymphoma or Multiple Myeloma.
Lymphoma, Non-Hodgkin
Association of Non-Hodgkin lymphoma risk with CYP1A1, GSTM1 and GSTT1 gene variants, in tobacco addicted patients of Pashtun ethnicity of Khyber Pakhtunkhwa, Pakistan.
Lymphoma, Non-Hodgkin
Cytochrome P450 Genetic Variations Can Predict mRNA Expression, Cyclophosphamide 4-Hydroxylation, and Treatment Outcomes in Chinese Patients With Non-Hodgkin's Lymphoma.
Lymphoma, Non-Hodgkin
Effect of cytochrome P450 3A4 inducers on the pharmacokinetic, pharmacodynamic and safety profiles of bortezomib in patients with multiple myeloma or non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
Effect of the Cytochrome P450 2C19 Inhibitor Omeprazole on the Pharmacokinetics and Safety Profile of Bortezomib in Patients with Advanced Solid Tumours, Non-Hodgkin's Lymphoma or Multiple Myeloma.
Lymphoma, Non-Hodgkin
Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphoma.
Lymphoma, Non-Hodgkin
Genetic Variations in Xenobiotic Metabolic Pathway Genes, Personal Hair Dye Use, and Risk of Non-Hodgkin Lymphoma.
Lymphoma, Non-Hodgkin
[Activity and induction of CYP2B, CYP2C, and CYP3A in tissues of cyclophosphane-sensitive and resistant neoplasms and the liver of neoplasm-carrying mice]
Lymphoma, T-Cell
Effects of paclitaxel, docetaxel and their combinations on subcutaneous lymphomas in inbred Sprague-Dawley/Cub rats.
Lymphoma, T-Cell
Polymorphisms of drug-metabolizing genes and risk of non-Hodgkin lymphoma.
Lymphoproliferative Disorders
Raltegravir: new Drug. Alternative to enfuvirtide/darunavir in multidrug-resistant HIV.
Macular Degeneration
Associations between CYP2C8 rs10509681 and rs11572080 gene polymorphisms and age-related macular degeneration.
Macular Degeneration
Associations between Rs4244285 and Rs762551 gene polymorphisms and age-related macular degeneration.
Macular Degeneration
Cytochrome P450 2C Epoxygenases Mediate Photochemical Stress-induced Death of Photoreceptors.
Macular Degeneration
Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1.
Macular Degeneration
Post-translational Modification by an Isolevuglandin Diminishes Activity of the Mitochondrial Cytochrome P450 27A1.
Malabsorption Syndromes
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Malaria
A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing insecticide-treated bednet efficacy.
Malaria
Age-related pyrethroid resistance is not a function of P450 gene expression in the major African malaria vector, Anopheles funestus (Diptera: Culicidae).
Malaria
Allelic Variation of Cytochrome P450s Drives Resistance to Bednet Insecticides in a Major Malaria Vector.
Malaria
Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.
Malaria
An adult-specific CYP6 P450 gene is overexpressed in a pyrethroid-resistant strain of the malaria vector, Anopheles gambiae.
Malaria
An expression of an insect membrane-bound cytochrome P450 CYP6AA3 in the Escherichia coli in relation to insecticide resistance in a malarial vector.
Malaria
Analysis of Sepik populations of Papua New Guinea suggests an increase of CYP2C19 null allele frequencies during the colonization of Melanesia.
Malaria
Characterization of Anopheles minimus CYP6AA3 expressed in a recombinant baculovirus system.
Malaria
Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus.
Malaria
Cloning of cytochrome P450, CYP6P5, and CYP6AA2 from Anopheles minimus resistant to deltamethrin.
Malaria
Combined over-expression of two cytochrome P450 genes exacerbates the fitness cost of pyrethroid resistance in the major African malaria vector Anopheles funestus.
Malaria
Correction: Cytochrome P450 metabolic resistance (CYP6P9a) to pyrethroids imposes a fitness cost in the major African malaria vector Anopheles funestus.
Malaria
CYP2B6*6 genotype and high efavirenz plasma concentration but not nevirapine are associated with low lumefantrine plasma exposure and poor treatment response in HIV-malaria-coinfected patients.
Malaria
CYP2C8 status of patients with malaria influences selection of Plasmodium falciparum pfmdr1 alleles after amodiaquine-artesunate treatment.
Malaria
CYP2D6 activity and the risk of recurrence of Plasmodium vivax malaria in the Brazilian Amazon: a prospective cohort study.
Malaria
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region.
Malaria
CYP2D6 Genetic Variation and Its Implication for Vivax Malaria Treatment in Madagascar.
Malaria
CYP6 P450 Enzymes and ACE-1 Duplication Produce Extreme and Multiple Insecticide Resistance in the Malaria Mosquito Anopheles gambiae.
Malaria
Cytochrome 1A1 induction by primaquine in human hepatocytes and HepG2 cells: absence of binding to the aryl hydrocarbon receptor.
Malaria
Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed.
Malaria
Cytochrome P450 CYP2B6*6 distribution among Congolese individuals with HIV, Tuberculosis and Malaria infection.
Malaria
Cytochrome P450 metabolic resistance (CYP6P9a) to pyrethroids imposes a fitness cost in the major African malaria vector Anopheles funestus.
Malaria
Differential Impact of Nevirapine on Artemether-Lumefantrine Pharmacokinetics in Individuals Stratified by CYP2B6 c.516G>T Genotypes.
Malaria
Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus.
Malaria
Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes.
Malaria
Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women.
Malaria
Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase 2 genes on the metabolism of artemisinin-based combination therapies in malaria patients from Cambodia and Tanzania.
Malaria
Effects of genetic variation at the CYP2C19/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians.
Malaria
Evaluation of efficacy and safety of a herbal medicine used for the treatment of malaria.
Malaria
Functional characterization of 50 CYP2D6 allelic variants by assessing primaquine 5-hydroxylation.
Malaria
Genetic variability of CYP2B6 polymorphisms in southeast Iranian population: implications for malaria and HIV/AIDS treatment.
Malaria
Genome-wide and expression-profiling analyses suggest the main cytochrome P450 genes related to pyrethroid resistance in the malaria vector, Anopheles sinensis (Diptera Culicidae).
Malaria
HIV-Positive Nigerian Adults Harbor Significantly Higher Serum Lumefantrine Levels than HIV-Negative Individuals Seven Days after Treatment for Plasmodium falciparum Infection.
Malaria
Human cytochrome P450 2B6 genetic variability in Botswana: a case of haplotype diversity and convergent phenotypes.
Malaria
In vitro analysis of the interaction between Atovaquone and Proguanil against malaria liver stage.
Malaria
Influence of cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate-amodiaquine treatment of uncomplicated Plasmodium falciparum malaria in Zanzibar.
Malaria
Inhibitory Activities of Thai Medicinal Plants with Promising Activities Against Malaria and Cholangiocarcinoma on Human Cytochrome P450.
Malaria
Isolation and sequence analysis of P450 genes from a pyrethroid resistant colony of the major malaria vector Anopheles funestus.
Malaria
Malaria downmodulates mRNA expression and catalytic activities of CYP1A2, 2E1 and 3A11 in mouse liver.
Malaria
Mefloquine resistance reversal action of ketoconazole - a cytochrome P450 inhibitor, against mefloquine-resistant malaria.
Malaria
Microarray and RNAi analysis of P450s in Anopheles gambiae male and female steroidogenic tissues: CYP307A1 is required for ecdysteroid synthesis.
Malaria
Molecular analysis of multiple cytochrome P450 genes from the malaria vector, Anopheles gambiae.
Malaria
Molecular basis of permethrin and DDT resistance in an Anopheles funestus population from Benin.
Malaria
Multiple relapses of Plasmodium vivax malaria acquired from West Africa and association with poor metabolizer CYP2D6 variant: a case report.
Malaria
Novel insights into Plasmodium vivax therapeutic failure: CYP2D6 activity and time of exposure to malaria modulate the risk of recurrence.
Malaria
Over expression of a cytochrome P450 (CYP6P9) in a major African malaria vector, Anopheles Funestus, resistant to pyrethroids.
Malaria
Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
Malaria
Positional cloning of rp2 QTL associates the P450 genes CYP6Z1, CYP6Z3 and CYP6M7 with pyrethroid resistance in the malaria vector Anopheles funestus.
Malaria
Possible isozyme-specific effects of experimental malaria infection with Plasmodium berghei on cytochrome P450 activity in rat liver microsomes.
Malaria
Preliminary investigation of the contribution of CYP2A6, CYP2B6, and UGT1A9 polymorphisms on artesunate-mefloquine treatment response in Burmese patients with Plasmodium falciparum malaria.
Malaria
Prevalence of CYP2D6 Genotypes and Predicted Phenotypes in a Cohort of Cambodians at High Risk for Infections with Plasmodium vivax.
Malaria
Proguanil disposition and toxicity in malaria patients from Vanuatu with high frequencies of CYP2C19 mutations.
Malaria
Protective efficacy of Anopheles minimus CYP6P7 and CYP6AA3 against cytotoxicity of pyrethroid insecticides in Spodoptera frugiperda (Sf9) insect cells.
Malaria
Pyrethroid Resistance in the Major Malaria Vector Anopheles funestus is Exacerbated by Overexpression and Overactivity of the P450 CYP6AA1 Across Africa.
Malaria
Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines.
Malaria
Safety and tolerability of single low-dose primaquine in a low-intensity transmission area in South Africa: an open-label, randomized controlled trial.
Malaria
The cytochrome P450 CYP325A is a major driver of pyrethroid resistance in the major malaria vector Anopheles funestus in Central Africa.
Malaria
The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria.
Malaria
The effects of acute falciparum malaria on the disposition of caffeine and the comparison of saliva and plasma-derived pharmacokinetic parameters in adult Nigerians.
Malaria
The highly polymorphic CYP6M7 cytochrome P450 gene partners with the directionally selected CYP6P9a and CYP6P9b genes to expand the pyrethroid resistance front in the malaria vector Anopheles funestus in Africa.
Malaria
The interplay between tubulins and P450 cytochromes during Plasmodium berghei invasion of Anopheles gambiae midgut.
Malaria
The lncRNA-miRNA-mRNA ceRNA network in mural granulosa cells of patients with polycystic ovary syndrome: an analysis of Gene Expression Omnibus data.
Malaria
The oxylipin and endocannabidome responses in acute phase Plasmodium falciparum malaria in children.
Malaria
The P450 CYP6Z1 confers carbamate/pyrethroid cross-resistance in a major African malaria vector beside a novel carbamate-insensitive N485I acetylcholinesterase-1 mutation.
Malaria
The pharmacokinetics of caffeine in Nigerian children suffering from malaria and kwashiorkor.
Malaria
The Prevalence of CYP2B6 Gene Polymorphisms in Malaria-endemic Population of Timor in East Nusa Tenggara Indonesia.
Malaria
Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major malaria vector.
Malaria
Two functionally distinct CYP4G genes of Anopheles gambiae contribute to cuticular hydrocarbon biosynthesis.
Malaria
Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa.
Malaria
Up- and down-modulation of liver cytochrome P450 activities and associated events in two murine malaria models.
Malaria
[Deltamethrin resistance, metabolic detoxification enzyme and kdr mutation in Anopheles sinensis in region along Huaihe River in Anhui Province].
Malaria
[Microsomal monooxygenase inhibitors as promising agents for overcoming the drug resistance of the malaria parasite]
Malaria, Falciparum
Analysis of Sepik populations of Papua New Guinea suggests an increase of CYP2C19 null allele frequencies during the colonization of Melanesia.
Malaria, Falciparum
Distribution of human CYP2C8*2 allele in three different African populations.
Malaria, Falciparum
Influence of cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate-amodiaquine treatment of uncomplicated Plasmodium falciparum malaria in Zanzibar.
Malaria, Falciparum
Preliminary investigation of the contribution of CYP2A6, CYP2B6, and UGT1A9 polymorphisms on artesunate-mefloquine treatment response in Burmese patients with Plasmodium falciparum malaria.
Malaria, Vivax
Association of Impaired Cytochrome P450 2D6 Activity Genotype and Phenotype With Therapeutic Efficacy of Primaquine Treatment for Latent Plasmodium vivax Malaria.
Malaria, Vivax
Case report: recurrence of Plasmodium vivax malaria due to defective cytochrome P450 2D6 function in Pos Lenjang, Pahang, Malaysia.
Malaria, Vivax
CYP2D6 activity and the risk of recurrence of Plasmodium vivax malaria in the Brazilian Amazon: a prospective cohort study.
Malaria, Vivax
CYP2D6 Genetic Variation and Its Implication for Vivax Malaria Treatment in Madagascar.
Malaria, Vivax
CYP2D6 Polymorphisms and the Safety and Gametocytocidal Activity of Single-Dose Primaquine for Plasmodium falciparum.
Malaria, Vivax
Impact of CYP2D6 Genetic Variation on Radical Cure of Plasmodium vivax Malaria.
Malaria, Vivax
Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients.
Malaria, Vivax
Multiple relapses of Plasmodium vivax malaria acquired from West Africa and association with poor metabolizer CYP2D6 variant: a case report.
Malaria, Vivax
Novel insights into Plasmodium vivax therapeutic failure: CYP2D6 activity and time of exposure to malaria modulate the risk of recurrence.
Malaria, Vivax
Primaquine ineligibility in anti-relapse therapy of Plasmodium vivax malaria: the problem of G6PD deficiency and cytochrome P-450 2D6 polymorphisms.
Malaria, Vivax
Real time PCR detection of common CYP2D6 genetic variants and its application in a Karen population study.
Malaria, Vivax
Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial.
Malaria, Vivax
The association of CYP2D6 gene polymorphisms in the full-length coding region with higher recurrence rate of vivax malaria in Yunnan Province, China.
Malnutrition
Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis.
Malnutrition
Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test.
Malnutrition
Effect of protein and calorie malnutrition on drug metabolism in rat - in vitro.
Malnutrition
Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis.
Malnutrition
Liver glutathione and cytochrome P450 activity in experimental infection: study of the relative effects of infectious stress and malnutrition.
Malnutrition
Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine.
Malnutrition
The effect of obesity, macronutrients, fasting and nutritional status on drug-metabolizing cytochrome P450s: a systematic review of current evidence on human studies.
Malnutrition
Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition.
Malnutrition
[Activity of delta-aminolevulinic synthetase, cytochrome oxidase and levels of the mixed function oxidase system during experimental protein malnutrition. Response to re-alimentation]
Manganese Poisoning
Polymorphism of metabolic genes and susceptibility to occupational chronic manganism.
Mania
Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N?=?1345 young and elderly subjects.
Mania
Role of Pharmacogenetics in Improving the Safety of Psychiatric Care by Predicting the Potential Risks of Mania in CYP2D6 Poor Metabolizers Diagnosed With Bipolar Disorder.
Marfan Syndrome
Variants in ADRB1 and CYP2C9: Association with Response to Atenolol and Losartan in Marfan Syndrome.
Mastitis
CYP1A1 Relieves Lipopolysaccharide-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells.
Mastitis
Feeding supplemental 25-hydroxyvitamin D3 increases serum mineral concentrations and alters mammary immunity of lactating dairy cows.
Mastitis
Intramammary 1,25-dihydroxyvitamin D3 treatment increases expression of host-defense genes in mammary immune cells of lactating dairy cattle.
Mastitis
Widespread basal cytochrome P450 expression in extrahepatic bovine tissues and isolated cells.
Mastocytoma
Incorporation and distribution of epoxyeicosatrienoic acids into cellular phospholipids.
Medullary Sponge Kidney
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
Medulloblastoma
CYP1A1 and CYP1B1 expressions in medulloblastoma cells are AhR-independent and have no direct link with resveratrol-induced differentiation and apoptosis.
Medulloblastoma
Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target.
Medulloblastoma
Differential regulation of CYP1A1 and CYP1B1 expression in resveratrol-treated human medulloblastoma cells.
Medulloblastoma
Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia?inducible factor 1??mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation.
Melanoma
Antiproliferative Activity of Non-Calcemic Vitamin D Analogs on Human Melanoma Lines in Relation to VDR and PDIA3 Receptors.
Melanoma
Application of Homolgy Modeling to Generate CYP1A1 Mutants with Enhanced Activation of the Cancer Chemotherapeutic Prodrug Dacarbazine.
Melanoma
CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies.
Melanoma
CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism.
Melanoma
Cytochrome P450 CYP2D6 genotypes: association with hair colour, Breslow thickness and melanocyte stimulating hormone receptor alleles in patients with malignant melanoma.
Melanoma
Different h2 receptor antihistamines dissimilarly retard the growth of xenografted human melanoma cells in immunodeficient mice.
Melanoma
Genetic susceptibility to environmental carcinogenesis in Slovenian melanoma patients.
Melanoma
Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study.
Melanoma
Metabolic bioactivation and toxicity of ethyl 4-hydroxybenzoate in human SK-MEL-28 melanoma cells.
Melanoma
Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1.
Melanoma
No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case-control study.
Melanoma
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
Melanoma
On the relationship between VDR, ROR? and ROR? receptors expression and HIF1-? levels in human melanomas.
Melanoma
On the role of classical and novel forms of vitamin D in melanoma progression and management.
Melanoma
Rat CYP24A1 acts on 20-hydroxyvitamin D(3) producing hydroxylated products with increased biological activity.
Melanoma
Selective Antitumor Effect of Shikonin Derived DMAKO-20 on Melanoma through CYP1B1.
Melanoma
Structural toxicity relationship of 4-alkoxyphenols' cytotoxicity towards murine B16-F0 melanoma cell line.
Melanoma
Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer.
Melanoma
Targeted delivery of CYP2E1 recombinant adenovirus to malignant melanoma by bone marrow-derived mesenchymal stem cells as vehicles.
Melanoma
Vitamin D receptors (VDR), hydroxylases CYP27B1 and CYP24A1 and retinoid-related orphan receptors (ROR) level in human uveal tract and ocular melanoma with different melanization levels.
Melanosis
Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays.
Memory Disorders
CYP1B1 deiciency ameliorates learning and memory deficits caused by high fat diet in mice.
Meningeal Neoplasms
Expression Profile of Genes Related to Drug Metabolism in Human Brain Tumors.
Meningioma
Forkhead Box M1 promotes the growth and tube formation of human malignant meningioma cells via the aryl hydrocarbon receptor signaling pathway.
Meningioma
Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors.
Meningioma
Overexpression of aryl hydrocarbon receptor (AHR) signalling pathway in human meningioma.
Meningioma
Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci.
Meningioma
Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors.
Meningioma
[Intracranial approach in the excision of olfactive meningioma with nasal prolongation.]
Meningitis
Differential alterations in levels of hepatic microsomal cytochrome P450 isozymes following intracerebroventricular injection of bacterial lipopolysaccharide in rats.
Menorrhagia
Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking.
Mesothelioma
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
Mesothelioma
Expression of mRNA for several enzymes of xenobiotic detoxification in normal and spontaneously transformed mesothelial cells and mesothelioma cells of rats.
Mesothelioma, Malignant
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
Mesothelioma, Malignant
Metabolic genotypes as modulators of asbestos-related pleural malignant mesothelioma risk: a comparison of Finnish and Italian populations.
Metabolic Diseases
Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.
Metabolic Diseases
Differential inhibition of naringenin on human and rat cytochrome P450 2E1 activity.
Metabolic Diseases
Enalapril reverses high-fat diet-induced alterations in cytochrome P450-mediated eicosanoid metabolism.
Metabolic Diseases
Potential role of CYP1B1 in the development and treatment of metabolic diseases.
Metabolic Diseases
Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia.
Metabolic Diseases
Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health.
Metabolic Diseases
The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases.
Metabolic Diseases
Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models.
Metabolic Syndrome
17? Estradiol Modulates Perfusion Pressure and Expression of 5-LOX and CYP450 4A in the Isolated Kidney of Metabolic Syndrome Female Rats.
Metabolic Syndrome
Age-dependent features of CYP3A, CYP2C, and CYP2E1 functioning at metabolic syndrome.
Metabolic Syndrome
Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant.
Metabolic Syndrome
Coffee intake and risk of obesity, metabolic syndrome and type 2 diabetes: a Mendelian randomization study.
Metabolic Syndrome
Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes.
Metabolic Syndrome
Cytochrome P450 2E1 participation in the pathogenesis of experimental metabolic syndrome in guinea pigs.
Metabolic Syndrome
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11?-hydroxylase.
Metabolic Syndrome
Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis.
Metabolic Syndrome
In Vivo Exposures to Particulate Matter Collected from Saudi Arabia or Nickel Chloride Display Similar Dysregulation of Metabolic Syndrome Genes.
Metabolic Syndrome
Metformin, Estrogen Replacement Therapy and Gonadotropin Inhibition Fail to Improve Insulin Sensitivity in a Girl with Aromatase Deficiency.
Metabolic Syndrome
Physiogenomic analysis of CYP450 drug metabolism correlates dyslipidemia with pharmacogenetic functional status in psychiatric patients.
Metabolic Syndrome
Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors alpha/delta dual agonists.
Metabolic Syndrome
The Associations of Novel Vitamin D3 Metabolic Gene CYP27A1 Polymorphism, Adiponectin/Leptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males.
Metabolic Syndrome
The regulatory effect of genistein on P450 aromatase and follicle-stimulating hormone receptor in mouse experimental model of menopausal metabolic syndrome.
Metabolic Syndrome
[Resistance to antiplatelet drugs in patients with cerebrovascular disorders].
Methemoglobinemia
Decrease in 4-aminobiphenyl-induced methemoglobinemia in Cyp1a2(-/-) knockout mice.
Methemoglobinemia
Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia.
Metrorrhagia
Risk-Benefit Assessment of Ethinylestradiol Using a Physiologically Based Pharmacokinetic Modeling Approach.
Migraine Disorders
A Metabolism-Based Synergy for Total Coumarin Extract of Radix Angelicae Dahuricae and Ligustrazine on Migraine Treatment in Rats.
Migraine Disorders
Association of MDR1, CYP2D6, and CYP2C19 gene polymorphisms with prophylactic migraine treatment response.
Migraine Disorders
Cytochrome P450 2D6 and glutathione S-transferase M1 genotypes and migraine.
Migraine Disorders
Ergotism in Thailand caused by increased access to antiretroviral drugs: a global warning.
Migraine Disorders
Investigation of polymorphisms in genes involved in estrogen metabolism in menstrual migraine.
Migraine Disorders
The metabolism of zolmitriptan: effects of an inducer and an inhibitor of cytochrome p450 on its pharmacokinetics in healthy volunteers.
Miosis
A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans.
Miosis
Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.
Miosis
Mechanism of Efavirenz Influence on Methadone Pharmacokinetics and Pharmacodynamics.
Miosis
Preclinical toxicology studies with nizatidine, a new H2-receptor antagonist: acute, subchronic, and chronic toxicity evaluations.
Mitochondrial Diseases
A case of cerebrotendinous xanthomatosis mimicking the clinical phenotype of mitochondrial disease with a novel frame-shift mutation (c. 43_44 delGG) in CYP27A1 gene exon 1.
Mouth Neoplasms
Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.
Mouth Neoplasms
Alteration of the Risk of Oral Pre-Cancer and Cancer in North India Population by CYP1A1 Polymorphism Genotypes and
Haplotype
Mouth Neoplasms
Areca nut components stimulate ADAM17, IL-1?, PGE2 and 8-isoprostane production in oral keratinocyte: role of reactive oxygen species, EGF and JAK signaling.
Mouth Neoplasms
Association between GSTM1 and CYP1A1 polymorphisms and survival in oral cancer patients.
Mouth Neoplasms
Association of CYP1A1 and GSTM1 Polymorphisms With Oral Cancer Susceptibility: A Meta-Analysis.
Mouth Neoplasms
Association of CYP1A1 MspI polymorphism with oral cancer risk in Asian populations: a meta-analysis.
Mouth Neoplasms
Carcinoma of the oral cavity in relation to aryl hydrocarbon hydroxylase inducibility, smoking and dental status.
Mouth Neoplasms
Cigarette smoke condensate induces cytochromes P450 and aldo-keto reductases in oral cancer cells.
Mouth Neoplasms
CYP1A1 and GSTM1 polymorphisms and oral cancer risk: association studies via evidence-based meta-analyses.
Mouth Neoplasms
CYP1A1 genotypes and haplotypes and risk of oral cancer: A case-control study in South Indians.
Mouth Neoplasms
CYP1A1 polymorphism interactions with smoking status in oral cancer risk: evidence from epidemiological studies.
Mouth Neoplasms
CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka.
Mouth Neoplasms
CYP2E1 Rsa I/Pst I polymorphism contributes to oral cancer susceptibility: a meta-analysis.
Mouth Neoplasms
CYP2E1 RsaI/PstI polymorphisms contributed to oral cancer susceptibility: a meta-analysis.
Mouth Neoplasms
Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis including 1,515 cases and 2,233 controls.
Mouth Neoplasms
Elucidation of CYP2E1 5' regulatory RsaI/Pstl allelic variants and their role in risk for oral cancer.
Mouth Neoplasms
Frequency of the functionally relevant aryl hydrocarbon receptor repressor (AhRR) Pro185Ala SNP in Papua New Guinea.
Mouth Neoplasms
Gene polymorphisms, tobacco exposure and oral cancer susceptibility: a study from Gujarat, West India.
Mouth Neoplasms
Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancer.
Mouth Neoplasms
Genetic polymorphism of drug metabolizing enzymes (GSTM1 and CYP1A1) as risk factors for oral premalignant lesions and oral cancer.
Mouth Neoplasms
Genetic Polymorphisms of ADH1C and CYP2E1 and Risk of Oral Squamous Cell Carcinoma.
Mouth Neoplasms
Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer.
Mouth Neoplasms
Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1; environmental factors and risk of oral cancer.
Mouth Neoplasms
Genetic Polymorphisms of the CYP2E1 Gene do not Contribute to Oral Cancer Susceptibility in South Indians.
Mouth Neoplasms
Genetic Susceptibility to Oral Cancer due to Combined Effects of GSTT1, GSTM1 and CYP1A1 Gene Variants in Tobacco Addicted Patients of Pashtun Ethnicity of Khyber Pakhtunkhwa Province of Pakistan.
Mouth Neoplasms
Genetically high susceptibility to oral squamous cell carcinoma in terms of combined genotyping of CYP1A1 and GSTM1 genes.
Mouth Neoplasms
GSTM1, GSTT1 and CYP1A1 polymorphisms and risk of oral cancer: a case-control study in Jakarta, Indonesia.
Mouth Neoplasms
Influence of CYP1A1, CYP2E1, GSTM3 and NAT2 genetic polymorphisms in oral cancer susceptibility: results from a case-control study in Rio de Janeiro.
Mouth Neoplasms
Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells.
Mouth Neoplasms
Oral cancer susceptibility associated with the CYP1A1 and GSTM1 genotypes in Chilean individuals.
Mouth Neoplasms
p53, but not p16 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use.
Mouth Neoplasms
Polymorphisms of CYP1A1, GSTM1 and GSTT1 Loci as the Genetic Predispositions of Oral Cancers and Other Oral Pathologies: Tobacco and Alcohol as Risk Modifiers.
Mouth Neoplasms
Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: impact on DNA adduct formation and prevention by polyphenols.
Mouth Neoplasms
Prevalence of CYP1A1 and GST polymorphisms in the population of northeastern India and susceptibility of oral cancer.
Mouth Neoplasms
Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6.
Mouth Neoplasms
Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator.
Mouth Neoplasms
Systems-level differential gene expression analysis reveals new genetic variants of oral cancer.
Mouth Neoplasms
Vitamin D receptor, CYP27B1 and CYP24A1 genes polymorphisms association with oral cancer risk and survival.
Mouth Neoplasms
[Application of molecular biology to occupational health field--the frequency of gene polymorphism of cytochrome P450 1A1 and glutathione S-transferase M1 in patients with lung, oral and urothelial cancer]
Mouth Neoplasms
[Correlation between smoking and the polymorphisms of cytochrome P450 1A1-Msp I and glutathione S-transferase T1 genes and oral cancer].
Movement Disorders
Antipsychotic drug-induced movement disorders in schizophrenics in relation to CYP2D6 genotype.
Movement Disorders
Association between CYP2D6 genotype and tardive dyskinesia in Korean schizophrenics.
Movement Disorders
Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
Movement Disorders
CYP2D6 genotype and antipsychotic-induced extrapyramidal side effects in schizophrenic patients.
Movement Disorders
Fluoxetine-induced movement disorders and deficient CYP2D6 enzyme activity.
Movement Disorders
Non-functional CYP2D6 alleles and risk for neuroleptic-induced movement disorders in schizophrenic patients.
Movement Disorders
Pharmacogenetic assessment of antipsychotic-induced movement disorders: contribution of the dopamine D3 receptor and cytochrome P450 1A2 genes.
Movement Disorders
Pharmacogenetics of response to antipsychotics in patients with schizophrenia.
Movement Disorders
Risperidone-associated adverse drug reactions and CYP2D6 polymorphisms in a South African cohort.
Mucocutaneous Lymph Node Syndrome
CYP2E1 Gene Polymorphisms Related to the Formation of Coronary Artery Lesions in Kawasaki Disease.
Mucocutaneous Lymph Node Syndrome
Height, VKORC1 1173, and CYP2C9 Genotypes Determine Warfarin Dose for Pediatric Patients with Kawasaki Disease in Southwest China.
Multiple Chemical Sensitivity
Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR.
Multiple Myeloma
A SNP in CYP2C8 is not associated with the development of bisphosphonate-related osteonecrosis of the jaw in men with castrate-resistant prostate cancer.
Multiple Myeloma
Association between CYP2C8 (rs1934951) Polymorphism and Bisphosphonate-Related Osteonecrosis of the Jaws in Patients on Bisphosphonate Therapy: A Meta-Analysis.
Multiple Myeloma
Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma.
Multiple Myeloma
Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis.
Multiple Myeloma
Bortezomib: new indication. Second-line treatment of myeloma: limited efficacy, major risks.
Multiple Myeloma
CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma.
Multiple Myeloma
Dll1/Notch activation contributes to bortezomib resistance by upregulating CYP1A1 in multiple myeloma.
Multiple Myeloma
Effect of cytochrome P450 3A4 inducers on the pharmacokinetic, pharmacodynamic and safety profiles of bortezomib in patients with multiple myeloma or non-Hodgkin's lymphoma.
Multiple Myeloma
Effect of the Cytochrome P450 2C19 Inhibitor Omeprazole on the Pharmacokinetics and Safety Profile of Bortezomib in Patients with Advanced Solid Tumours, Non-Hodgkin's Lymphoma or Multiple Myeloma.
Multiple Myeloma
Influence of genetic polymorphisms in CYP3A4, CYP3A5, GSTP1, GSTM1, GSTT1 and MDR1 genes on survival and therapy-related toxicity in multiple myeloma.
Multiple Myeloma
Involvement of the arachidonic acid cytochrome P450 epoxygenase pathway in the proliferation and invasion of human multiple myeloma cells.
Multiple Myeloma
No influence of the polymorphisms CYP2C19 and CYP2D6 on the efficacy of cyclophosphamide, thalidomide, and bortezomib in patients with Multiple Myeloma.
Multiple Myeloma
Pharmacogenetics of medication-related osteonecrosis of the jaw: a systematic review and meta-analysis.
Multiple Myeloma
Rare naturally occurring immune responses to three epitopes from the widely expressed tumour antigens hTERT and CYP1B1 in multiple myeloma patients.
Multiple Sclerosis
Association between age at onset of multiple sclerosis and vitamin D level-related factors.
Multiple Sclerosis
CYP27A1, CYP24A1, and RXR-? Polymorphisms, Vitamin D, and Multiple Sclerosis: a Pilot Study.
Multiple Sclerosis
CYP4F Enzymes are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis.
Multiple Sclerosis
Enantioselectivity in the Metabolism of Cyclophosphamide in Patients With Multiple or Systemic Sclerosis.
Multiple Sclerosis
Expression of CYP24A1 and other multiple sclerosis risk genes in peripheral blood indicates response to vitamin D in homeostatic and inflammatory conditions.
Multiple Sclerosis
Genetic evidence for a pathogenic role for the vitamin D3 metabolizing enzyme CYP24A1 in multiple sclerosis.
Multiple Sclerosis
Interferon-beta treatment in patients with multiple sclerosis does not alter CYP2C19 or CYP2D6 activity.
Multiple Sclerosis
Multiple sclerosis and exposure to organic solvents, investigated by genetic polymorphisms of the GSTM1 and CYP2D6 enzyme systems.
Multiple Sclerosis
Therapeutic protein-drug interaction assessment for daclizumab high-yield process in patients with multiple sclerosis using a cocktail approach.
Multiple Sclerosis
VDR and CYP24A1 Expression Analysis in Iranian Relapsing-Remitting Multiple Sclerosis Patients.
Multiple Sclerosis
[Association between vitamin D status and CYP27b1 and CYP24A1 gene polymorphisms in patients with multiple sclerosis in the Altai region].
Multiple Sclerosis
[Association of vitamin D metabolism enzyme gene polymorphisms with multiple sclerosis risk: pilot study].
Multiple Sclerosis, Relapsing-Remitting
VDR and CYP24A1 Expression Analysis in Iranian Relapsing-Remitting Multiple Sclerosis Patients.
Multiple System Atrophy
A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism.
Multiple System Atrophy
CYP2D6-debrisoquine hydroxylase gene polymorphism in multiple system atrophy.
Muscle Cramp
Increased brain vitamin D receptor expression and decreased expression of cathelicidin antimicrobial peptide in individuals who died by suicide.
Muscular Diseases
A Pharmacogenomic Dissection of a Rosuvastatin-Induced Rhabdomyolysis Case Evokes the Polygenic Nature of Adverse Drug Reactions.
Muscular Diseases
Clinical implications of pharmacogenetic variation on the effects of statins.
Muscular Diseases
Combination lipid-lowering therapy with statins: safety issues in the postcerivastatin era.
Muscular Diseases
Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions.
Muscular Diseases
Effect of thyroid hormone status and concomitant medication on statin induced adverse effects in hyperlipidemic patients.
Muscular Diseases
HMG-CoA reductase inhibitors: assessing differences in drug interactions and safety profiles.
Muscular Diseases
Impact of pharmacogenetics on statin-induced myopathy in South-Indian subjects.
Muscular Diseases
Incidence of adverse events with HMG-CoA reductase inhibitors in liver transplant patients.
Muscular Diseases
Low myopathy rates associated with statins as monotherapy or combination therapy with interacting drugs in a group model health maintenance organization.
Muscular Diseases
Major Cardiac-Psychiatric Drug-Drug Interactions: a Systematic Review of the Consistency of Drug Databases.
Muscular Diseases
Risk management of simvastatin or atorvastatin interactions with CYP3A4 inhibitors.
Muscular Diseases
The role of cytochrome P450-mediated drug-drug interactions in determining the safety of statins.
Muscular Diseases
The SLCO1B1*5 Genetic Variant Is Associated With Statin-Induced Side Effects.
Myalgia
Incidence of adverse events with HMG-CoA reductase inhibitors in liver transplant patients.
Myalgia
Late response to rosuvastatin and statin-related myalgia due to SLCO1B1, SLCO1B3, ABCB11, and CYP3A5 variants in a patient with Familial Hypercholesterolemia: a case report.
Myasthenia Gravis
Dose optimisation of tacrolimus with therapeutic drug monitoring and CYP3A5 polymorphism in myasthenia gravis patients.
Mycetoma
Polymorphisms in catechol-O-methyltransferase and cytochrome p450 subfamily 19 genes predispose towards Madurella mycetomatis-induced mycetoma susceptibility.
Mycoplasma Infections
Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6.
Mycoses
Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus.
Mycoses
Host-induced gene silencing of cytochrome P450 lanosterol C14?-demethylase-encoding genes confers strong resistance to Fusarium species.
Mycoses
In Silico Structural Modeling and Analysis of Interactions of Tremellomycetes Cytochrome P450 Monooxygenases CYP51s with Substrates and Azoles.
Mycoses
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF.
Mycoses
Resistance to Fusarium Head Blight and Seedling Blight in Wheat Is Associated with Activation of a Cytochrome P450 Gene
Mycoses
Resistance to Fusarium head blight and seedling blight in wheat is associated with activation of a cytochrome p450 gene.
Mycoses
Voriconazole-induced Severe Hyperkalemia Precipitated by Multiple Drug Interactions.
Mydriasis
Two separate dose-dependent effects of paroxetine: mydriasis and inhibition of tramadol's O-demethylation via CYP2D6.
Myelodysplastic Syndromes
CYP2B6 gene single nucleotide polymorphisms and leukemia susceptibility.
Myocardial Infarction
A population-based study of the drug interaction between proton pump inhibitors and clopidogrel.
Myocardial Infarction
Allelic variants of cytochromes P450 2C modify the risk for acute myocardial infarction.
Myocardial Infarction
Aripiprazole-induced atrial fibrillation in a patient with concomitant risk factors.
Myocardial Infarction
Association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms with myocardial infarction in South Indian population.
Myocardial Infarction
Cigarette smoking might weaken the prognostic significance of cytochrome P450 2C19*2 polymorphism in acute myocardial infarction patients.
Myocardial Infarction
Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) registry.
Myocardial Infarction
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.
Myocardial Infarction
CYP1A2 polymorphism (C > A at position -163) in Ovambos, Koreans and Mongolians.
Myocardial Infarction
CYP2D6 is a major determinant of metoprolol disposition and effects in hospitalized Russian patients treated for acute myocardial infarction.
Myocardial Infarction
Cytochrome p450 2C enzymes contribute to peritransplant ischemic injury and cardiac allograft vasculopathy.
Myocardial Infarction
Cytochrome p450 2C inhibition reduces post-ischemic vascular dysfunction.
Myocardial Infarction
Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study.
Myocardial Infarction
Cytochrome P450 2C19 Polymorphism, Suboptimal Reperfusion and All-Cause Mortality in Patients with Acute Myocardial Infarction.
Myocardial Infarction
Cytochrome p450 gene variants, race, and mortality among clopidogrel-treated patients after acute myocardial infarction.
Myocardial Infarction
Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction.
Myocardial Infarction
Genetic variance in CYP2C8 and increased risk of myocardial infarction.
Myocardial Infarction
Genetic variation, ?-blockers, and perioperative myocardial infarction.
Myocardial Infarction
Impact of CYP2C8 and 2C9 polymorphisms on coronary artery disease and myocardial infarction in the LURIC cohort.
Myocardial Infarction
Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction - a prospective observational study.
Myocardial Infarction
Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel.
Myocardial Infarction
Influences of Smoking Status on Effectiveness of Cytochrome P450 Enzyme System Metabolized Medications in Reducing In-Hospital Death in 14 658 Patients With Acute Myocardial Infarction: Data From CPACS-3 Study.
Myocardial Infarction
Inhibition of cardiac cytochrome P450: a new approach to cardiac ischaemia and reperfusion damage.
Myocardial Infarction
Letter by Hnid and Chtioui regarding article, "Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Registry".
Myocardial Infarction
Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases.
Myocardial Infarction
Myocardial infarction following the combined recreational use of Viagra and cannabis.
Myocardial Infarction
Platelet inhibition by adjunctive cilostazol versus high maintenance-dose clopidogrel in patients with acute myocardial infarction according to cytochrome P450 2C19 genotype.
Myocardial Infarction
Sulfaphenazole Attenuates Myocardial Cell Apoptosis Accompanied With Cardiac Ischemia-Reperfusion by Suppressing the Expression of BimEL and Noxa.
Myocardial Infarction
Sulfaphenazole protects heart against ischemia-reperfusion injury and cardiac dysfunction by overexpression of iNOS leading to enhancement of nitric-oxide bioavailability and tissue oxygenation.
Myocardial Infarction
Switching from prasugrel to clopidogrel based on Cytochrome P450 2C19 genotyping in East Asian patients stabilized after acute myocardial infarction.
Myocardial Infarction
Synergistic effect of cytochrome P450 epoxygenase CYP2J2*7 polymorphism with smoking on the onset of premature myocardial infarction.
Myocardial Infarction
The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9.
Myocardial Infarction
Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction.
Myocardial Infarction
[Association of CYP2C19 and CYP3A5 gene polymorphisms with myocardial infarction].
Myocardial Ischemia
Cytochrome 2C19 and paraoxonase-1 polymorphisms and clopidogrel resistance in ischemic heart disease patients.
Myocardial Ischemia
Cytochrome p450 2C (CYP2C) in ischemic heart injury and vascular dysfunction.
Myocardial Ischemia
Cytochrome P450 and ischemic heart disease: current concepts and future directions.
Myocardial Ischemia
Cytochrome P450 and myocardial ischemia: potential pharmacological implication for cardioprotection.
Myocardial Ischemia
Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice.
Myocardial Ischemia
The relationship between plasma concentration of metoprolol and CYP2D6 genotype in patients with ischemic heart disease.
Myocardial Reperfusion Injury
Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity.
Myocardial Stunning
Cytochrome P450-2D6 Genotype Definition May Improve Therapy for Paroxysmal Atrial Fibrillation A Case of Syncope Following "Pill-in-the-Pocket" Quinidine plus Propafenone.
Myocarditis
Proteomics analyses for the global proteins in the brain tissues of different human prion diseases.
Myoclonus
Myoclonus After Dextromethorphan Administration in Peritoneal Dialysis (January) (FREE).
Myoclonus
Seizures and myoclonus associated with antidepressant treatment: assessment of potential risk factors, including CYP2D6 and CYP2C19 polymorphisms, and treatment with CYP2D6 inhibitors.
Myoma
Aromatase expression in the eutopic endometrium of myomatous uteri: the influence of the menstrual cycle and oral contraceptive use.
Myoma
Protein Expression of Estrogen Receptors ? and ? and Aromatase in Myometrium and Uterine Leiomyoma.
Myoma
Relationship between aromatase activity and steroid receptor levels in ovarian tumors from postmenopausal women.
Myoma
[Association of polymorph variants of CYP1A2 and CYP1A1 genes with reproductive and thyroid diseases in female workers of petrochemical industry].
Myotonic Dystrophy
Linkage relationships of the apolipoprotein C1 gene and a cytochrome P450 gene (CYP2A) to myotonic dystrophy.
Myotoxicity
Alcohol-associated rhabdomyolysis: ethanol induction of cytochrome P450 may potentiate myotoxicity.
Myotoxicity
Cerivastatin in vitro metabolism by CYP2C8 variants found in patients experiencing rhabdomyolysis.
Myotoxicity
Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance.
Myotoxicity
Severe Rhabdomyolysis due to Presumed Drug Interactions between Atorvastatin with Amlodipine and Ticagrelor.
Myotoxicity
Statin-Induced Myotoxicity: Pharmacokinetic Differences among Statins and the Risk of Rhabdomyolysis, with Particular Reference to Pitavastatin.
nadph-hemoprotein reductase deficiency
Mutations of human cytochrome P450 reductase differentially modulate heme oxygenase-1 activity and oligomerization.
nadph-hemoprotein reductase deficiency
P450 oxidoreductase deficiency: a new disorder of steroidogenesis affecting all microsomal P450 enzymes.
nadph-hemoprotein reductase deficiency
P450 Oxidoreductase deficiency: Analysis of mutations and polymorphisms.
nadph-hemoprotein reductase deficiency
Reply to Flück et al.: Alternative androgen pathway biosynthesis drives fetal female virilization in P450 oxidoreductase deficiency.
Nasal Polyps
The expression of 11?-hydroxysteroid dehydrogenase type 1 and 2 in nasal polyp-derived epithelial cells and its possible contribution to glucocorticoid activation in nasal polyp.
Nasopharyngeal Carcinoma
A Case-Control and a Family-Based Association Study Revealing an Association between CYP2E1 Polymorphisms and Nasopharyngeal Carcinoma Risk in Cantonese.
Nasopharyngeal Carcinoma
CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan.
Nasopharyngeal Carcinoma
CYP2E1 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis.
Nasopharyngeal Carcinoma
Cytochrome P450 2E1 polymorphism and nasopharyngeal carcinoma development in Thailand: a correlative study.
Nasopharyngeal Carcinoma
Expression of CYP2E1 in human nasopharynx and its metabolic effect in vitro.
Nasopharyngeal Carcinoma
Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China.
Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma and genetic polymorphisms of DNA repair enzymes XRCC1 and hOGG1.
Nasopharyngeal Carcinoma
No association between genetic polymorphisms of CYP1A1, GSTM1, GSTT1, GSTP1, NAT2, and nasopharyngeal carcinoma in Taiwan.
Nasopharyngeal Carcinoma
Polymorphisms of CYP2E1 rs2031920 is not Associated with Risk of Nasopharyngeal Carcinoma in Minangkabau Ethnic Group.
Nasopharyngeal Carcinoma
The association between gene polymorphisms and risk of nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients.
Nasopharyngeal Carcinoma
[Association of nasopharyngeal carcinoma risk with cytochrome P450 CYP1A1 gene polymorphisms]
Nasopharyngeal Carcinoma
[Cloning and sequence analysis of human embryonic nasopharyngeal epithelial CYP2E1 cDNA]
Nasopharyngeal Carcinoma
[Expression of cytochrome P450 enzymes in human nasopharyngeal carcinoma and non-cancerous nasopharynx tissue]
Nasopharyngeal Neoplasms
Association of nasopharyngeal cancer risk with genetic polymorphisms of drug-metabolizing enzyme genes GSTM1, GSTT1 and CYP1A1 (rs4646903 variant), in tobacco addicted patients of Pashtun ethnicity of Khyber Pakhtunkhwa Province of Pakistan.
Nasopharyngeal Neoplasms
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Nasopharyngeal Neoplasms
The polymorphism of CYP2E1 Rsa I/Pst I gene and susceptibility to respiratory system cancer: a systematic review and meta-analysis of 34 studies.
Nasopharyngeal Neoplasms
[Expression of human cytochrome P450 2E1 gene in embryonic nasopharynx, nasopharyngeal cancer cell lines and tissue]
Nasopharyngeal Neoplasms
[Stable expression of human cytochrome P450 2E1 cDNA in nasopharyngeal cancer cell line CNE-2]
Neonatal Abstinence Syndrome
Variations in Infant CYP2B6 Genotype Associated with the Need for Pharmacological Treatment for Neonatal Abstinence Syndrome in Infants of Methadone-Maintained Opioid-Dependent Mothers.
Neoplasm Metastasis
27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression.
Neoplasm Metastasis
ABCB1 and ABCC2 and the risk of distant metastasis in Thai breast cancer patients treated with tamoxifen.
Neoplasm Metastasis
Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2.
Neoplasm Metastasis
Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors.
Neoplasm Metastasis
Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population.
Neoplasm Metastasis
Attenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): From bench to clinic.
Neoplasm Metastasis
Chromosomal region 15q21.1 is a frequent target of allelic imbalance in advanced breast carcinomas.
Neoplasm Metastasis
CYP genes in osteosarcoma: Their role in tumorigenesis, pulmonary metastatic microenvironment and treatment response.
Neoplasm Metastasis
CYP1B1 Enhances Cell Proliferation and Metastasis through Induction of EMT and Activation of Wnt/?-Catenin Signaling via Sp1 Upregulation.
Neoplasm Metastasis
CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies.
Neoplasm Metastasis
CYP24A1 is a potential biomarker for the progression and prognosis of human colorectal cancer.
Neoplasm Metastasis
CYP27A1 and CYP24 expression as a function of malignant transformation in the colon.
Neoplasm Metastasis
CYP2A6 overexpression in human lung cancers correlates with a high malignant status.
Neoplasm Metastasis
Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer.
Neoplasm Metastasis
CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling.
Neoplasm Metastasis
CYP3A5 suppresses metastasis of lung adenocarcinoma through ATOH8/Smad1 axis.
Neoplasm Metastasis
CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis.
Neoplasm Metastasis
Cytochrome P450 1A1 (CYP1A1) polymorphism and susceptibility to esophageal cancer: an updated meta-analysis of 27 studies.
Neoplasm Metastasis
Cytochrome P450 2A6 is associated with macrophage polarization and is a potential biomarker for hepatocellular carcinoma.
Neoplasm Metastasis
Cytochrome P450 ?-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer.
Neoplasm Metastasis
Cytochrome P450 content in primary tumors and liver metastases of patients with metastatic colorectal cancer.
Neoplasm Metastasis
Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma.
Neoplasm Metastasis
Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
Neoplasm Metastasis
DNA polymorphism and risk of esophageal squamous cell carcinoma in a population of North Xinjiang, China.
Neoplasm Metastasis
Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion.
Neoplasm Metastasis
Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma.
Neoplasm Metastasis
Effects of ellagic Acid on angiogenic factors in prostate cancer cells.
Neoplasm Metastasis
Erlotinib-induced Hepatotoxicity-Clinical Presentation and Successful Management: A Case Report.
Neoplasm Metastasis
Gene Expression of CYP1A1 and its Possible Clinical Application in Thyroid Cancer Cases.
Neoplasm Metastasis
GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer.
Neoplasm Metastasis
Hepatic CYP1A2 activity in liver tumors and the implications for preoperative volume-function analysis.
Neoplasm Metastasis
Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation.
Neoplasm Metastasis
Hypomethylation of the XRE -1383 site is associated with the upregulation of CYP1A1 in gastric adenocarcinoma.
Neoplasm Metastasis
Identification of co-expression modules and pathways correlated with osteosarcoma and its metastasis.
Neoplasm Metastasis
Identification of cytochrome P450 enzymes in human colorectal metastases and the surrounding liver: a proteomic approach.
Neoplasm Metastasis
Impact of IGF-I and CYP19 gene polymorphisms on the survival of patients with metastatic prostate cancer.
Neoplasm Metastasis
Inflammatory breast cancer: Activation of the aryl hydrocarbon receptor and its target CYP1B1 correlates closely with Wnt5a/b-?-catenin signalling, the stem cell phenotype and disease progression.
Neoplasm Metastasis
Micro1278 Leads to Tumor Growth Arrest, Enhanced Sensitivity to Oxaliplatin and Vitamin D and Inhibits Metastasis via KIF5B, CYP24A1, and BTG2, Respectively.
Neoplasm Metastasis
MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer (NSCLC) through down-regulation of CYP1B1.
Neoplasm Metastasis
miR-30a promoter variation contributes to the increased risk of colorectal cancer in an Iranian population.
Neoplasm Metastasis
N,N-diethyl-2-[4-(phenylmethyl) phenoxy] ethanamine (DPPE; tesmilifene), a chemopotentiating agent with hormetic effects on DNA synthesis in vitro, may improve survival in patients with metastatic breast cancer.
Neoplasm Metastasis
No effect of thromboxane A2 on the attachment of tumor cell lines MDA MB 231, DU145, and U937 to the basement membrane in an in-vitro model.
Neoplasm Metastasis
On the relationship between VDR, ROR? and ROR? receptors expression and HIF1-? levels in human melanomas.
Neoplasm Metastasis
Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer.
Neoplasm Metastasis
Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study.
Neoplasm Metastasis
Prediction of Early Recurrence After Curative Resection of Colorectal Liver Metastasis and Subsequent S-1 Chemotherapy.
Neoplasm Metastasis
Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.
Neoplasm Metastasis
Prognostic value of using glucosylceramide synthase and cytochrome P450 family 1 subfamily A1 expression levels for patients with triple-negative breast cancer following neoadjuvant chemotherapy.
Neoplasm Metastasis
Relationship between CYP1A1 polymorphisms and invasion and metastasis of breast cancer.
Neoplasm Metastasis
Self-packed core shell nano liquid chromatography columns and silica-based monolithic trap columns for targeted proteomics.
Neoplasm Metastasis
Silencing TAK1 alters gene expression signatures in bladder cancer cells.
Neoplasm Metastasis
Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6.
Neoplasm Metastasis
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells.
Neoplasm Metastasis
The Consequences of Soluble Epoxide Hydrolase Deletion on Tumorigenesis and Metastasis in a Mouse Model of Breast Cancer.
Neoplasm Metastasis
The Pathogenic Effects of Fusobacterium nucleatum on the Proliferation, Osteogenic Differentiation, and Transcriptome of Osteoblasts.
Neoplasm Metastasis
The prognostic values of CYP2B6 genetic polymorphisms and metastatic sites for advanced breast cancer patients treated with docetaxel and thiotepa.
Neoplasm Metastasis
The role of aromatase and 17-beta-hydroxysteroid dehydrogenase type 1 mRNA expression in predicting the clinical outcome of human breast cancer.
Neoplasm Metastasis
Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung.
Neoplasm Metastasis
Vitamin D-neutralizing CYP24A1 expression, oncogenic mutation states and histological findings of human papillary thyroid cancer.
Neoplasm Metastasis
[Study on the Difference of Gene Expression between Central and Peripheral Lung Squamous Cell Carcinoma Based on TCGA Database].
Neoplasms
(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent.
Neoplasms
1-Methyl-D-tryptophan activates aryl hydrocarbon receptor, a pathway associated with bladder cancer progression.
Neoplasms
27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.
Neoplasms
7,12-Dimethylbenz[a]anthracene inhibition of steroid production in MA-10 mouse Leydig tumor cells is not directly linked to induction of CYP1B1.
Neoplasms
7-ethoxyresorufin O-deethylase (EROD) activity is not capable of reflecting the overall malignant potential of breast cancer tissue.
Neoplasms
Neoplasms
?-3 Polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice.
Neoplasms
?-3 Polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer.
Neoplasms
A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors.
Neoplasms
A clinical investigation of inhibitory effect of panobinostat on CYP2D6 substrate in patients with advanced cancer.
Neoplasms
A clinical protocol for treatment of canine mammary tumors using encapsulated, cytochrome P450 synthesizing cells activating cyclophosphamide: a phase I/II study.
Neoplasms
A Combined Molecular Docking/Dynamics Approach to Probe the Binding Mode of Cancer Drugs with Cytochrome P450 3A4.
Neoplasms
A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption.
Neoplasms
A comparative study of hepatic and colonic metabolic enzymes in inbred mouse lines before and after treatment with the colon carcinogen, 1,2-dimethylhydrazine.
Neoplasms
A comparison between lung carcinoma and a subcutaneous malignant tumor induced in rats by a 3,4-benzopyrene injection.
Neoplasms
A comparison of the pharmacokinetics and pharmacodynamics of docetaxel between African-American and Caucasian cancer patients: CALGB 9871.
Neoplasms
A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.
Neoplasms
A constitutive deficiency in the monooxygenase system of spontaneous mouse liver tumors.
Neoplasms
A cytochrome P450 2B6 meditated gene therapy strategy to enhance the effects of radiation or cyclophosphamide when combined with the bioreductive drug AQ4N.
Neoplasms
A discordance of the cytochrome P450 2C19 genotype and phenotype in patients with advanced cancer.
Neoplasms
A drug-drug interaction study to assess the effect of the CYP1A2 inhibitor fluvoxamine on the pharmacokinetics of dovitinib (TKI258) in patients with advanced solid tumors.
Neoplasms
A high throughput screening assay to screen for CYP2E1 metabolism and inhibition using a fluorogenic vivid p450 substrate.
Neoplasms
A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction.
Neoplasms
A hydroxylated flavonol, fisetin inhibits the formation of a carcinogenic estrogen metabolite.
Neoplasms
A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2.
Neoplasms
A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.
Neoplasms
A method for assaying aryl hydrocarbon hydroxylase in man using fibroblasts cultured in vitro from oral mucosa.
Neoplasms
A new opportunity for nanomedicines: Micellar cytochrome P450 inhibitors to improve drug efficacy in a cancer therapy model.
Neoplasms
A new role for tamoxifen in oestrogen receptor-negative breast cancer when it is combined with epigallocatechin gallate.
Neoplasms
A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis.
Neoplasms
A novel methodology for enhanced and consistent heterologous expression of unmodified human cytochrome P450 1B1 (CYP1B1).
Neoplasms
A novel mutant allele of the CYP2A6 gene (CYP2A6*11 ) found in a cancer patient who showed poor metabolic phenotype towards tegafur.
Neoplasms
A phase II study of perioperative S-1 combined with weekly docetaxel in patients with locally advanced gastric carcinoma: clinical outcomes and clinicopathological and pharmacogenetic predictors for survival.
Neoplasms
A possible modulatory influence of melatonin on representative phase I and II drug metabolizing enzymes in 9,10-dimethyl-1,2-benzanthracene induced rat mammary tumorigenesis.
Neoplasms
A possible role for dihydrodiol dehydrogenase in the formation of benzo[a]pyrene-DNA adducts in lung cancer cells and tumor tissues.
Neoplasms
A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis.
Neoplasms
A Reversed-Phase Mode LC-MS/MS Method Using a Polysaccharide Chiral Selector for Simultaneous Quantitation of Each Enantiomer of Tramadol and its Metabolites in Human Plasma and Evaluation of CYP-Mediated Stereoselective Demethylation.
Neoplasms
A review of gene-drug interactions for nonsteroidal anti-inflammatory drug use in preventing colorectal neoplasia.
Neoplasms
A risk assessment of atrazine use in California: human health and ecological aspects.
Neoplasms
A Simulation Study to Compare the Treatment Effect of Tamoxifen by CYP2D6 Genotypes and Third-Generation Aromatase Inhibitors.
Neoplasms
A steroidogenic factor-1-binding site and cyclic adenosine 3',5'-monophosphate response element-like elements are required for the activity of the rat aromatase promoter in rat Leydig tumor cell lines.
Neoplasms
A systematic review on hepatoprotective activity of quercetin against various drugs and toxic agents: Evidence from preclinical studies.
Neoplasms
A virus-directed enzyme prodrug therapy (VDEPT) strategy for lung cancer using a CYP2B6/NADPH-cytochrome P450 reductase fusion protein.
Neoplasms
Abemaciclib Does Not Have a Clinically Meaningful Effect on Pharmacokinetics of CYP1A2, CYP2C9, CYP2D6, and CYP3A4 Substrates in Patients with Cancer.
Neoplasms
Abiraterone and Ionizing Radiation Alter the Sphingolipid Homeostasis in Prostate Cancer Cells.
Neoplasms
Absence of a differential induction of cytochrome P450 2E1 by different alcoholic beverages in rats: implications for the aetiology of human oesophageal cancer.
Neoplasms
Activating Mutations of ESR1, BRCA1 and CYP19 Aromatase Genes Confer Tumor Response in Breast Cancers Treated with Antiestrogens.
Neoplasms
Activation of aflatoxin B1 by expression of human CYP1A2 polymorphisms in Saccharomyces cerevisiae.
Neoplasms
Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function.
Neoplasms
Activation of oxazaphosphorines by cytochrome P450: Application to gene-directed enzyme prodrug therapy for cancer.
Neoplasms
Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells.
Neoplasms
Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes.
Neoplasms
Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2.
Neoplasms
Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2.
Neoplasms
Activation of thio-tepa cytotoxicity toward human breast-cancer cells by hepatic cytochrome-p450.
Neoplasms
Adductomic signatures of benzene exposure provide insights into cancer induction.
Neoplasms
Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+.
Neoplasms
Adenovirus-mediated targeted gene therapy for breast cancer and for purging hematopoietic stem-cell sources.
Neoplasms
Adult granulosa cell tumors of the ovary: a retrospective study of 30 cases with respect to the expression of steroid synthesis enzymes.
Neoplasms
Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation.
Neoplasms
Alcohol and cancer: an overview with special emphasis on the role of acetaldehyde and cytochrome P450 2E1.
Neoplasms
Alcohol oxidizing enzymes and ethanol-induced cytotoxicity in rat pancreatic acinar AR42J cells.
Neoplasms
Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis.
Neoplasms
Aldosterone-producing adrenocortical carcinoma with prominent hepatic metastasis diagnosed by liver biopsy: a case report.
Neoplasms
Alleles of polymorphic sites that correspond to hyperactive variants of CYP1B1 protein are significantly less frequent in Japanese as compared to American and German populations.
Neoplasms
Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice.
Neoplasms
Alteration of the Risk of Oral Pre-Cancer and Cancer in North India Population by CYP1A1 Polymorphism Genotypes and
Haplotype
Neoplasms
Alteration of xenobiotic metabolizing enzymes by resveratrol in liver and lung of CD1 mice.
Neoplasms
Alterations in expression of CYP1A1 and NADPH-cytochrome P450 reductase during lung tumor development in SWR/J mice.
Neoplasms
Alterations in ubiquitin ligase Siah-2 and its corepressor N-CoR after P-MAPA immunotherapy and anti-androgen therapy: new therapeutic opportunities for non-muscle invasive bladder cancer.
Neoplasms
Altered cytochrome 2E1 and 3A P450-dependent drug metabolism in advanced ovarian cancer correlates to tumour-associated inflammation.
Neoplasms
Altered expression of cytochrome P450 enzymes involved in metabolism of androgens and vitamin D in the prostate as a risk factor for prostate cancer.
Neoplasms
Altered expression of cytochrome P450 mRNA during chemical-induced hepatocarcinogenesis and following partial hepatectomy.
Neoplasms
Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages.
Neoplasms
An early complement-dependent and TLR-4-independent phase in the pathogenesis of ethanol-induced liver injury in mice.
Neoplasms
An evaluation of the drug interaction potential of pazopanib, an oral vascular endothelial growth factor receptor tyrosine kinase inhibitor, using a modified cooperstown 5+1 cocktail in patients with advanced solid tumors.
Neoplasms
An Excess of CYP24A1, Lack of CaSR, and a Novel lncRNA Near the PTH Gene Characterize an Ectopic PTH-Producing Tumor.
Neoplasms
An Open-Label Study to Assess the Effect of Itraconazole and Rifampin on Parsaclisib Pharmacokinetics When Administered Orally in Healthy Participants.
Neoplasms
An original administration of ifosfamide given once every other week: a clinical and pharmacological study.
Neoplasms
An update on drug-drug interactions with biologics for the treatment of moderate-to-severe psoriasis.
Neoplasms
Analysis of ?-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital.
Neoplasms
Analysis of CYP2D6 expression in human lung: implications for the association between CYP2D6 activity and susceptibility to lung cancer.
Neoplasms
Analysis of CYP450 gene allelic variants can predict ifosfamide toxicity in Mexican paediatric patients.
Neoplasms
Analysis of cytochrome P450 2E1 genetic polymorphisms in relation to human lung cancer.
Neoplasms
Analysis of point mutation in exon 2 of CYP2E1 gene in renal cell/urothelial cancer patients in comparison with control population.
Neoplasms
Analysis of RNA from brush cytology detects changes in B2M, CYP1B1 and KRT17 levels with OSCC in tobacco users.
Neoplasms
Analyzing the differentially expressed genes and pathway cross-talk in aggressive breast cancer.
Neoplasms
Androgens inhibit aromatase expression through DAX-1: insights into the molecular link between hormone balance and Leydig cancer development.
Neoplasms
ANNALS EXPRESS: Influence of cytochrome P450 genotype on the plasma disposition of prochlorperazine metabolites and their relationships with clinical responses in cancer patients.
Neoplasms
Anti-Colorectal Cancer Mechanisms of Formononetin Identified by Network Pharmacological Approach.
Neoplasms
Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice.
Neoplasms
Anti-tumor activities of lipids and lipid analogues and their development as potential anticancer drugs.
Neoplasms
Anticancer activity of litchi fruit pericarp extract against human breast cancer in vitro and in vivo.
Neoplasms
Antimutagenic Effects of Selenium-Enriched Polysaccharides from Pyracantha fortuneana through Suppression of Cytochrome P450 1A Subfamily in the Mouse Liver.
Neoplasms
Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice.
Neoplasms
Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats.
Neoplasms
Antiproliferative and antioxidant potential of beta-ionone against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
Neoplasms
Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism.
Neoplasms
Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines.
Neoplasms
Antitumor activity of methoxymorpholinyl doxorubicin: potentiation by cytochrome P450 3A metabolism.
Neoplasms
Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPAR?-mediated lipogenic gene expression.
Neoplasms
Application of Homolgy Modeling to Generate CYP1A1 Mutants with Enhanced Activation of the Cancer Chemotherapeutic Prodrug Dacarbazine.
Neoplasms
Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration.
Neoplasms
Aromatase (CYP19) promoter gene polymorphism and risk of nonviral hepatitis-related hepatocellular carcinoma.
Neoplasms
Aromatase Acetylation Patterns and Altered Activity in Response to Sirtuin Inhibition.
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Aromatase activity induction in human adipose fibroblasts by retinoic acids via retinoic acid receptor ?.
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Aromatase and comparative response to its inhibitors in two types of endometrial cancer.
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Aromatase cytochrome P450 and estrogen and progesterone receptors in uterine sarcomas: correlation with clinical parameters.
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Aromatase cytochrome P450 enzyme expression in prolactinomas and its relationship to tumor behavior.
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Aromatase inhibition and experimental antitumor activity of FCE 24304, MDL 18962 and SH 489.
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Aromatic DNA adducts in coke-oven workers, in relation to exposure, lifestyle and genetic polymorphism of metabolic enzymes.
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Aryl hydrocarbon hydroxylase activity in chemically induced and toremifene-treated mammary tumors in rats.
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Aryl hydrocarbon hydroxylase activity in human lung tissue: in relation to cigarette smoking and lung cancer.
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Aryl hydrocarbon hydroxylase activity in pulmonary alveolar macrophages and lymphocytes from lung cancer and noncancer patients: a correlation with family histories of cancer.
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Aryl hydrocarbon hydroxylase activity in pulmonary macrophages and blood lymphocytes. Asbestos-exposed cigarette smokers with and without lung cancer.
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Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls.
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Aryl hydrocarbon hydroxylase inducibility among primary relatives of children with leukemia or solid tumors.
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Aryl hydrocarbon hydroxylase induction levels in patients with malignant tumors associated with smoking.
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Aryl hydrocarbon receptor plays a significant role in mediating airborne particulate-induced carcinogenesis in mice.
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Aryl hydrocarbon receptor-dependent cell cycle arrest in isolated mouse oval cells.
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Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice.
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Assessment of cancer susceptibility in humans by use of genetic polymorphisms in carcinogen metabolism.
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Assessment of effects of repeated oral doses of fedratinib on inhibition of cytochrome P450 activities in patients with solid tumors using a cocktail approach.
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Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo.
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Assessment of the drug interaction potential and single- and repeat-dose pharmacokinetics of the BRAF inhibitor dabrafenib.
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Association between CYP1A1 Ile462Val variation and acute leukemia risk: meta-analyses including 2164 cases and 4160 controls.
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Association between CYP2C8 (rs1934951) Polymorphism and Bisphosphonate-Related Osteonecrosis of the Jaws in Patients on Bisphosphonate Therapy: A Meta-Analysis.
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Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.
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Association between CYP2E1 genetic polymorphisms and urinary cancer risk: a meta-analysis.
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Association between genetic polymorphisms of CYP1A2, arylamine N-acetyltransferase 1 and 2 and susceptibility to cholangiocarcinoma.
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Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk: a case control study in Japan.
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Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and glutathione S-transferase P1 and CYP1A1 polymorphisms.
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Association between telomere length and CYP19 TTTA repetition polymorphism in healthy and breast cancer-diagnosed women.
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Association between the CYP1A1 A2455G polymorphism and risk of cancer: evidence from 272 case-control studies.
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Association between the CYP1A1 T3801C polymorphism and risk of cancer: evidence from 268 case-control studies.
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Association between the CYP1A2 polymorphisms and risk of cancer: a meta-analysis.
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Association between the CYP1B1 polymorphisms and risk of cancer: a meta-analysis.
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Association between the CYP3A4 and CYP3A5 polymorphisms and cancer risk: a meta-analysis and meta-regression.
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Association of a novel seven-gene expression signature with the disease prognosis in colon cancer patients.
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Association of ABCB1, 5-HT3B Receptor and CYP2D6 Genetic Polymorphisms with Ondansetron and Metoclopramide Antiemetic Response in Indonesian Cancer Patients Treated with Highly Emetogenic Chemotherapy.
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Association of aryl hydrocarbon receptor and cytochrome P4501B1 expressions in human non-small cell lung cancers.
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Association of cyclophosphamide drug-metabolizing enzyme polymorphisms and chemotherapy-related ovarian failure in breast cancer survivors.
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Association of CYP1A1 A4889G and T6235C polymorphisms with the risk of sporadic breast cancer in Brazilian women.
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Association of CYP1A1 polymorphisms with differential metabolic activation of 17beta-estradiol and estrone.
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Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue.
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Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer.
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Association of CYP1B1 L432V polymorphism with urinary cancer susceptibility: a meta-analysis.
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Association of CYP24A1 gene polymorphism with colorectal cancer in the Jiamusi population.
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Association of CYP2A6 gene deletion with cancers in Japanese elderly: an autopsy study.
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Association of CYP2A6 gene deletion with cigarette smoking status in Japanese adults.
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Association of CYP2D6 genotype and tamoxifen metabolites with breast cancer recurrence in a low-dose trial.
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Association of CYP2E1 gene polymorphism with predisposition to cancer development.
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Association of CYP3A4/5 genotypes and expression with the survival of patients with neuroblastoma.
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Association of CYP3A5 Expression and Vincristine Neurotoxicity in Pediatric Malignancies in Turkish Population.
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Association of Cytochrome CYP1A1 Gene Polymorphisms and Tobacco Smoking With the Risk of Breast Cancer in Women From Iraq.
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Association of cytochrome P450 2E1 genetic polymorphisms with squamous cell carcinoma of the oesophagus.
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Association of cytochrome P450 2E1 polymorphisms and head and neck squamous cell cancer.
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Association of genetic polymorphisms in CYP19 and CYP1A1 with the oestrogen receptor-positive breast cancer risk.
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Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women.
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Association of Genetic Variants of CYP2C19 and CYP2D6 with Esophageal Squamous Cell Carcinoma Risk in Northern India, Kashmir.
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Association of The Common CYP1A1*2C Variant (Ile462Val Polymorphism) with Chronic Myeloid Leukemia (CML) in Patients Undergoing Imatinib Therapy.
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Association of the CYP1A1 MspI and TNF?-308 polymorphisms with chronic obstructive pulmonary disease in Inner Mongolia.
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Association of the CYP1B1 Leu432Val polymorphism with the risk of prostate cancer: a meta-analysis.
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Association of the CYP24A1-rs2296241 polymorphism of the vitamin D catabolism enzyme with hormone-related cancer risk: a meta-analysis.
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Association studies of CYP1A1 and GSTM1 polymorphisms with esophageal cancer risk: evidence-based meta-analyses.
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Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population.
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Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race.
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Associations of ABCB1 3435C>T and IL-10-1082G>A polymorphisms with long-term sirolimus dose requirements in renal transplant patients.
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Associations of Biomarkers of Inflammation and Breast Cancer in the Breast Adipose Tissue of Women with Combined Measures of Adiposity.
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Atezolizumab plus bevacizumab combination enables an unresectable hepatocellular carcinoma resectable and links immune exclusion and tumor dedifferentiation to acquired resistance.
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Attenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): From bench to clinic.
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Baculovirus P35 protein: An overview of its applications across multiple therapeutic and biotechnological arenas.
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Basal cell carcinomas: association of allelic variants with a high-risk subgroup of patients with the multiple presentation phenotype.
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Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing.
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Benzo[a]pyrene-dependent activation of transcription factors NF-kappaB and AP-1 related to tumor promotion in hepatoma cell cultures.
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Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration.
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Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells.
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Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats.
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Biochemical characterization of in vivo alkylating agent resistance of a murine EMT-6 mammary carcinoma. Implication for systemic involvement in the resistance phenotype.
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Biochemistry and enzyme induction in MC-29 virus-induced transplantable avian hepatoma.
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Biological oxidations and P450 reactions. Recombinant mouse CYP1B1 expressed in Escherichia coli exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1B1.
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Biomarkers of susceptibility and effect in car painters exposed to organic solvents.
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Biomonitoring of exposure to urban air pollutants: analysis of sister chromatid exchanges and DNA lesions in peripheral lymphocytes of traffic policemen.
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Black tea polyphenols modulate xenobiotic-metabolizing enzymes, oxidative stress and adduct formation in a rat hepatocarcinogenesis model.
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Boschniakia rossica prevents the carbon tetrachloride-induced hepatotoxicity in rat.
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Breast cancer risk associated with CYP1A1 genetic polymorphisms in Japanese women.
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Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility.
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Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes.
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Caffeine Cytochrome P450 1A2 Metabolic Phenotype Does Not Predict the Metabolism of Heterocyclic Aromatic Amines in Humans.
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Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide.
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Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor.
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Cancer cachexia raises the plasma concentration of oxymorphone through the reduction of CYP3A but not CYP2D6 in oxycodone-treated patients.
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Cancer chemoprevention revisited: Cytochrome P450 family 1B1 as a target in the tumor and the microenvironment.
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Cancer chemopreventive and anti-inflammatory activities of chemically modified guar gum.
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Cancer stem cells and nanomedicine: new opportunities to combat multidrug resistance?
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Cancer, inflammation, and therapy: effects on cytochrome p450-mediated drug metabolism and implications for novel immunotherapeutic agents.
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Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN.
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Cannabis and anticancer drugs: societal usage and expected pharmacological interactions - a review.
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Carcinogen Metabolism Pathway and Tumor Suppressor Gene Polymorphisms and Gallbladder Cancer Risk in North Indians: A Hospital-Based Case-Control Study.
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Carvedilol serves as a novel CYP1B1 inhibitor, a systematic drug repurposing approach through structure-based virtual screening and experimental verification.
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Catalytic characterization and cytokine mediated regulation of cytochrome P450 4Fs in rat hepatocytes.
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Celery extract inhibits mouse CYP2A5 and human CYP2A6 activities via different mechanisms.
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Cellular levels of class 1 and class 3 aldehyde dehydrogenases and certain other drug-metabolizing enzymes in human breast malignancies.
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Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.
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Characteristic CYP2A6 genetic polymorphisms detected by TA cloning-based sequencing in Chinese digestive system cancer patients with S-1 based chemotherapy.
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Characterization and functional analysis of two common human cytochrome P450 1B1 variants.
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Characterization and prevalence of a polymorphism in the 3' untranslated region of cytochrome P4501A1 in cancer-prone Atlantic tomcod.
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Characterization of a human cell clone expressing cytochrome P450 for safe use in human somatic cell therapy.
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Characterization of a single peptide derived from cytochrome P450 1B1 that elicits spontaneous human leukocyte antigen (HLA)-A1 as well as HLA-B35 restricted CD8 T-cell responses in cancer patients.
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Characterization of common CYP1B1 variants with different capacity for benzo[a]pyrene-7,8-dihydrodiol epoxide formation from benzo[a]pyrene.
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Characterization of differences in substrate specificity among CYP1A1, CYP1A2 and CYP1B1: an integrated approach employing molecular docking and molecular dynamics simulations.
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Characterization of the isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution LC-MS, and quantitative HPLC analysis.
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Chemomodulatory effects of Azadirachta indica on the hepatic status of skin tumor bearing mice.
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Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice.
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Chemopreventive efficacy of anethole trithione, N-acetyl-L-cysteine, miconazole and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model.
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Chemopreventive potential of dietary bioflavonoids against 20-methylcholanthrene-induced tumorigenesis.
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Chemopreventive task of capsaicin against benzo(a)pyrene-induced lung cancer in Swiss albino mice.
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Chemoresistance in Malignant Intracranial Tumors: Longer Survival with Negative MDR1 Expression.
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Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53.
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Chronic moderate ethanol intake differentially regulates vitamin D hydroxylases gene expression in kidneys and xenografted breast cancer cells in female mice.
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Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1.
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Circulating 27-hydroxycholesterol and breast cancer tissue expression of CYP27A1, CYP7B1, LXR-?, and ER?: results from the EPIC-Heidelberg cohort.
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Clinical effects of A4889G and T6235C polymorphisms in cytochrome P-450 CYP1A1 for breast cancer patients treated with tamoxifen: implications for tumor aggressiveness and patient survival.
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Clinical implications of CYP2D6 genotyping in tamoxifen treatment for breast cancer.
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Clinical pharmacokinetics of tyrosine kinase inhibitors: focus on 4-anilinoquinazolines.
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Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5.
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Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue.
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Cloning and sequence analysis of the cDNA encoding P-450 aromatase (P450arom) from a rainbow trout (Oncorhynchus mykiss) ovary; relationship between the amount of P450arom mRNA and the production of oestradiol-17 beta in the ovary.
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Co-administration of obeticholic acid and simvastatin protects against high-fat diet-induced non-alcoholic steatohepatitis in mice.
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Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status.
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Collaboration between hepatic and intratumoral prodrug activation in a P450 prodrug-activation gene therapy model for cancer treatment.
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Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins.
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Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells.
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Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy.
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Combinations of cytochrome P-450 genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study.
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Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer.
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Combined effects of gender, skin type and polymorphic genes on clinical phenotype: use of rate of increase in numbers of basal cell carcinomas as a model system.
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Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility.
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Combined treatment with specific ligands for PPARgamma:RXR nuclear receptor system markedly inhibits the expression of cytochrome P450arom in human granulosa cancer cells.
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Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia.
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Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.
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Comparative Expression Analysis of Cytochrome P450 1A1, Cytochrome P450 1B1 and Nuclear Receptors in the Female Genital and Colorectal Tissues of Human and Pigtailed Macaque.
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Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines.
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Comparative proteomics among cytochrome p450 family 1 for differential substrate specificity.
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Comparative untargeted proteomic analysis of ADME proteins and tumor antigens for tumor cell lines.
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Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes.
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Comparison of the hepatic and renal effects of 1,4-dichlorobenzene in the rat and mouse.
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Comparison of the pharmacokinetics and pharmacodynamics of S-1 between Caucasian and East Asian patients.
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Comparison of the polymorphic regions of the cytochrome P450 CYP2E1 gene of humans and patas and cynomolgus monkeys.
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Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues.
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Complementarity of genotoxic and nongenotoxic predictors of rodent carcinogenicity.
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Comprehensive CYP2D6 genotype and adherence affect outcome in breast cancer patients treated with tamoxifen monotherapy.
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Computational identification and binding analysis of orphan human cytochrome P450 4X1 enzyme with substrates.
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Concomitance of oncogenic HPV types, CHEK2 gene mutations, and CYP1B1 gene polymorphism as an increased risk factor for malignancy.
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Concordance Between CYP2D6 Genotypes Obtained From Tumor-Derived and Germline DNA.
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Constitutive and inducible expression of cytochromes P4501A (CYP1A1 and CYP1A2) in normal prostate and prostate cancer cells.
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Constitutive expression of AhR and BRCA-1 promoter CpG hypermethylation as biomarkers of ER?-negative breast tumorigenesis.
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Constitutive regulation of CYP1B1 by the aryl hydrocarbon receptor (AhR) in pre-malignant and malignant mammary tissue.
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Contribution of ABCB1 and CYP2D6 genotypes to the outcome of tamoxifen adjuvant treatment in premenopausal women with breast cancer.
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Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors.
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Copper-mediated oxidative DNA damage induced by eugenol: possible involvement of O-demethylation.
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Correlation of polymorphic expression of CYP2D6 mRNA in bladder mucosa and tumor tissue to in vivo debrisoquine hydroxylase activity.
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Correlation of PPM1A Downregulation with CYP3A4 Repression in the Tumor Liver Tissue of Hepatocellular Carcinoma Patients.
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Correlation of xenobiotic-metabolizing enzymes, oxidative stress and NFkappaB signaling with histological grade and menopausal status in patients with adenocarcinoma of the breast.
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Correspondence re: C. Chen et al., CYP2D6 genotype and the incidence of anal and vulvar cancer. Cancer Epidemiol. Biomark. Prev., 8: 317-321, 1999.
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Correspondence re: letter to the editor by B. K. Tang and W. Kalow on CYP1A2 phenotyping using caffeine. Cancer Epidemiol. Biomarkers & Prev., 5: 231, 1996.
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Critical appraisal of the expression of cytochrome P450 enzymes in human lung and evaluation of the possibility that such expression provides evidence of potential styrene tumorigenicity in humans.
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Current evidence on the relationship between three polymorphisms in the CYP1A2 gene and the risk of cancer.
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CXCR4 promotes cisplatin-resistance of non-small cell lung cancer in a CYP1B1-dependent manner.
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Cyclamen Trochopteranthum: Cytotoxic activity and possible adverse interactions including drugs and carcinogens.
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Cyclin D1, glutathione S-transferase, and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: assessment of the importance of individual genes using multivariate analysis.
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Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study.
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CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer.
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CYP genes in osteosarcoma: Their role in tumorigenesis, pulmonary metastatic microenvironment and treatment response.
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CYP19 (aromatase cytochrome P450) gene expression in human malignant endometrial tumors.
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CYP19 gene expression and aromatase activity in endometrial cancer tissue: importance of the type of the disease.
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CYP19 genetic polymorphism haplotype AASA is associated with a poor prognosis in premenopausal women with lymph node-negative, hormone receptor-positive breast cancer.
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CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies.
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CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms and bladder cancer risk in a Turkish population.
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CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
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CYP1A1 and GSTM1 polymorphic genotypes in patients with prostate cancer in a Turkish population.
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CYP1A1 and GSTM1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis.
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CYP1A1 and GSTM1 polymorphisms and oral cancer risk: association studies via evidence-based meta-analyses.
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CYP1A1 gene polymorphism as a risk factor for cervical intraepithelial neoplasia and invasive cervical cancer.
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CYP1A1 gene polymorphisms: lack of association with breast cancer susceptibility in the southern region (Madurai) of India.
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CYP1A1 I462V polymorphism is associated with reduced genotoxicity in yeast despite positive association with increased cancer risk.
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CYP1A1 inducing potential of airborne particulate extracts collected during a 25-year period (1975-2000).
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CYP1A1 Msp1 T/C polymorphism in esophageal cancer: no association and risk modulation.
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CYP1A1 polymorphisms and the risk of upper aerodigestive tract cancers in an Indian population.
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CYP1A1 protein activity is associated with allelic variation in pterygium tissues and cells.
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CYP1A1 Relieves Lipopolysaccharide-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells.
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CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people.
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CYP1A1, CYP2E1, and GSTM1 Gene Polymorphisms and Susceptibility to Colorectal and Gastric Cancer Among Lebanese.
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CYP1A1, GSTM1, GSTT1 and TP53 Polymorphisms and Risk of Gallbladder Cancer in Bolivians.
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CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice.
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CYP1A2 rs762551 polymorphism contributes to cancer susceptibility: a meta-analysis from 19 case-control studies.
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CYP1A2 suppresses hepatocellular carcinoma through antagonizing HGF/MET signaling.
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CYP1B1 Activates Wnt/?-Catenin Signaling through Suppression of Herc5-Mediated ISGylation for Protein Degradation on ?-Catenin in HeLa Cells.
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CYP1B1 C4326G polymorphism and susceptibility to cervical cancer in Chinese Han women.
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CYP1B1 determines susceptibility to low doses of 7,12-dimethylbenz[a]anthracene-induced ovarian cancers in mice: correlation of CYP1B1-mediated DNA adducts with carcinogenicity.
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CYP1B1 Enhances Cell Proliferation and Metastasis through Induction of EMT and Activation of Wnt/?-Catenin Signaling via Sp1 Upregulation.
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CYP1B1 enhances the resistance of epithelial ovarian cancer cells to paclitaxel in vivo and in vitro.
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Cyp1b1 exerts opposing effects on intestinal tumorigenesis via exogenous and endogenous substrates.
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CYP1B1 expression in prostate is higher in the peripheral than in the transition zone.
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CYP1B1 expression is induced by docetaxel: effect on cell viability and drug resistance.
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CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention.
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CYP1B1 gene polymorphisms correlate with an increased risk of urinary bladder cancer in India.
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CYP1B1 genotype and risk of cardiovascular disease, pulmonary disease, and cancer in 50,000 individuals.
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CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma.
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Cyp1B1 mRNA expression in correlation to cotinine levels with respect to the Cyp1B1 L432V gene polymorphism.
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CYP1B1 Polymorphisms and K-ras Mutations in Patients with Pancreatic Ductal Adenocarcinoma.
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CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKC? activation and phosphorylation of XIAP.
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CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma.
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CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers.
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CYP24A1 and CYP27B1 Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence.
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Cyp24a1 attenuation limits progression of BrafV600E-induced papillary thyroid cancer cells and sensitizes them to BRAFV600E inhibitor PLX4720.
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CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies.
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CYP24A1 is a potential biomarker for the progression and prognosis of human colorectal cancer.
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CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma.
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CYP24A1 rs1570669 Variant Has a Protective Effect against Tumors of the Urinary System.
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CYP24A1 splice variants-Implications for the antitumorigenic actions of 1,25-(OH)(2)D(3) in colorectal cancer.
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CYP27A1 and CYP24 expression as a function of malignant transformation in the colon.
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CYP27A1 expression is associated with risk of late lethal estrogen receptor-positive breast cancer in postmenopausal patients.
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CYP2A5 Induction and Hepatocellular Stress: An Adaptive Response to Perturbations of Heme Homeostasis.
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CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk.
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CYP2A6 and the plasma level of 5-chloro-2, 4-dihydroxypyridine are determinants of the pharmacokinetic variability of tegafur and 5-fluorouracil, respectively, in Japanese patients with cancer given S-1.
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CYP2A6 genotyping methods and strategies using real-time and end point PCR platforms.
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CYP2A6 overexpression in human lung cancers correlates with a high malignant status.
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Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer.
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CYP2C8 and CYP2C9 polymorphisms in relation to tumour characteristics and early breast cancer related events among 652 breast cancer patients.
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CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population.
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CYP2C9 genotype does not affect risk of tobacco-related cancer in the general population.
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CYP2C9 inhibits the invasion and migration of esophageal squamous cell carcinoma via downregulation of HDAC.
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CYP2D6 gene variants in urban/admixed and Amerindian populations of Venezuela: pharmacogenetics and anthropological implications.
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CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen.
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CYP2D6 genetic polymorphisms are associated with susceptibility to pituitary tumors.
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CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women with Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial.
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CYP2D6 genotype in relation to tamoxifen efficacy in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial.
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CYP2D6 genotype predicts tamoxifen side effects but not cancer-free or survival benefits in postmenopausal ER+ and/or PgR+ breast cancers.
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CYP2E1 genotyping in renal cell/urothelial cancer patients in comparison with control populations.
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CYP2E1 polymorphism, cigarette smoking, p53 expression, and survival in non-small cell lung cancer: a long term follow-up study.
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CYP2E1 polymorphisms and gene-environment interactions in the risk of upper aerodigestive tract cancers among Indians.
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CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking.
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CYP2E1 RsaI/PstI polymorphism and gastric cancer susceptibility: meta-analyses based on 24 case-control studies.
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CYP2W1 is highly expressed in adrenal glands and is positively associated with the response to mitotane in adrenocortical carcinoma.
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CYP3A genotypes and treatment response in paediatric acute lymphoblastic leukaemia.
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CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans.
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CYP3A isoforms in Ewing's sarcoma tumours: an immunohistochemical study with clinical correlation.
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CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling.
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CYP3A5 genotype and its impact on vincristine pharmacokinetics and development of neuropathy in Kenyan children with cancer.
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CYP3A5 genotype and midazolam clearance in Australian patients receiving chemotherapy.
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CYP3A5 genotypes and risk of oesophageal cancer in two South African populations.
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CYP3A5 is unlikely to mediate anticancer drug resistance in hepatocellular carcinoma.
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CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma.
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CYP3A5*3 Affects Plasma Disposition of Noroxycodone and Dose Escalation in Cancer Patients Receiving Oxycodone.
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CYP3A5*3 and bilirubin predict midazolam population pharmacokinetics in Asian cancer patients.
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Cytochrome 450 metabolites of arachidonic acid (20-HETE, 11,12-EET and 14,15-EET) promote pheochromocytoma cell growth and tumor associated angiogenesis.
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Cytochrome P-450 and acetyltransferase expression as biomarkers of carcinogen-DNA adduct levels and human cancer susceptibility.
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Cytochrome P-450 isozyme pattern is related to individual susceptibility to diethylnitrosamine-induced liver cancer in rats.
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Cytochrome P1B1 (CYP1B1) polymorphisms and cancer risk: a meta-analysis of 52 studies.
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Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer.
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Cytochrome P450 1A1 and 1B1 promoter CpG island methylation regulates rat liver injury induced by isoniazid.
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Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6.
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Cytochrome P450 1A1 gene polymorphisms and digestive tract cancer susceptibility: a meta-analysis.
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Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis including 1,515 cases and 2,233 controls.
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Cytochrome P450 1A2 activity and incidence of thyroid disease and cancer after chronic or acute exposure to dioxins.
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Cytochrome P450 1A2 Metabolizes 17?-Estradiol to Suppress Hepatocellular Carcinoma.
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Cytochrome P450 1A2 overcomes nuclear factor kappa B-mediated sorafenib resistance in hepatocellular carcinoma.
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Cytochrome P450 1B1 (CYP1B1) gene polymorphisms as predictors of anticancer drug activity: studies with in vitro models.
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Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development.
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Cytochrome P450 1B1 and 2C9 Genotypes and Risk of Ischemic Vascular Disease, Cancer, and Chronic Obstructive Pulmonary Disease.
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Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation.
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Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target.
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Cytochrome P450 1B1 expression in rat esophageal tumorigenesis promoted by gastric and duodenal reflux.
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Cytochrome P450 1B1 inhibition suppresses tumorigenicity of prostate cancer via caspase-1 activation.
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Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer.
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Cytochrome P450 1B1 mRNA untranslated regions interact to inhibit protein translation.
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Cytochrome P450 1B1 polymorphism drives cancer cell stemness and patient outcome in head-and-neck carcinoma.
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Cytochrome P450 1B1 promotes cancer cell survival via specificity protein 1 (Sp1)-mediated suppression of death receptor 4.
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Cytochrome P450 1B1, a new keystone in gene-environment interactions related to human head and neck cancer?
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Cytochrome P450 1B1: a major P450 isoenzyme in human blood monocytes and macrophage subsets.
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Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance.
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Cytochrome P450 2E1 gene polymorphism and alcohol drinking on the risk of hepatocellular carcinoma: a meta-analysis.
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Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects.
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Cytochrome P450 2E1 is responsible for the initiation of 1,2-dichloropropane-induced liver damage.
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Cytochrome P450 2E1 polymorphism in gastric cancer in Brazil: case-control studies of Japanese Brazilians and non-Japanese Brazilians.
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Cytochrome P450 2E1 variable number tandem repeat polymorphisms and health risks: a genotype-phenotype study in cancers associated with drinking and/or smoking.
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Cytochrome P450 2W1 (CYP2W1) - ready for use as the biomarker and drug target for cancer?
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Cytochrome P450 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: impact on cancer therapy.
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Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes.
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Cytochrome P450 4A11 expression in tumor cells: A favorable prognostic factor for hepatocellular carcinoma patients.
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Cytochrome P450 Allele CYP3A7*1C Associates with Adverse Outcomes in Chronic Lymphocytic Leukemia, Breast, and Lung Cancer.
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Cytochrome P450 Bioconjugate as a Nanovehicle for Improved Chemotherapy Treatment.
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Cytochrome P450 content in primary tumors and liver metastases of patients with metastatic colorectal cancer.
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Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.
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Cytochrome P450 CYP1B1 protein expression: a novel mechanism of anticancer drug resistance.
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Cytochrome P450 CYP2D6 genotypes: association with hair colour, Breslow thickness and melanocyte stimulating hormone receptor alleles in patients with malignant melanoma.
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Cytochrome P450 enzyme-mediated auto-enhanced photodynamic cancer therapy of co-nanoassembly between clopidogrel and photosensitizer.
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Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer. Preface.
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Cytochrome P450 isoenzyme mRNA expression pattern in human urinary bladder malignancies and normal urothelium.
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Cytochrome P450 isoforms. Regulation during infection, inflammation and by cytokines.
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Cytochrome P450 isozyme distribution in normal and tumor-bearing hepatic tissue from rainbow trout (Salmo gairdneri).
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Cytochrome p450 metabolism of betel quid-derived compounds: implications for the development of prevention strategies for oral and pharyngeal cancers.
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Cytochrome P450 polymorphisms as risk factors for steroid hormone-related cancers.
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Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
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Cytochrome P450 reductase dependent inhibition of cytochrome P450 2B1 activity: Implications for gene directed enzyme prodrug therapy.
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Cytochrome p450 retinoic acid 4-hydroxylase inhibitors: potential agents for cancer therapy.
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Cytochrome P450- and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency.
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Cytochrome P450-based gene therapy for cancer treatment: from concept to the clinic.
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Cytochrome P4501A1 gene polymorphism and homozygous deletion of the glutathione S-transferase M1 gene in urothelial cancer patients.
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Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[a]anthracene.
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Cytochrome P4502C9 genotype in Southeast Anatolia and possible relation with some serum tumour markers and cytokines.
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Cytochrome P4502E1 (CYP2E1) Genetic Polymorphisms in a Lebanese Population: Frequency Distribution and Association with Morbid Diseases.
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Cytochrome P4502E1 genetic polymorphisms and risk of nasopharyngeal carcinoma: results from a case-control study conducted in Taiwan.
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Cytochrome P4502E1 inhibitor, chlormethiazole, decreases lipopolysaccharide-induced inflammation in rat Kupffer cells with ethanol treatment.
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Cytochromes P4502E1 and P4501A1 genotypes and susceptibility to cirrhosis or upper aerodigestive tract cancer in alcoholic caucasians.
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Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture.
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Dafachronic acid inhibits C. elegans germ cell proliferation in a DAF-12-dependent manner.
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DDE and PCB 153 independently induce aryl hydrocarbon receptor (AhR) expression in peripheral blood mononuclear cells.
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Debrisoquine 4-hydroxylase (CYP2D6) genetic polymorphisms and susceptibility to schizophrenia in Chinese patients from Taiwan.
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Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes.
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Decreased expression of cytochrome P450 2E1 is associated with poor prognosis of hepatocellular carcinoma.
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Decreased expression of cytochrome P450 protein in non-malignant colonic tissue of patients with colonic adenoma.
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Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients.
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Decreased hepatic drug metabolising enzyme activity in rats with nitrosamine-induced tumours.
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Depression of constitutive murine cytochromes P450 by staphylococcal enterotoxin B.
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Depression of hepatic drug metabolism in endotoxin-treated and sarcoma-bearing mice.
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Deregulation of signaling pathways controlling cell survival and proliferation in cancer cells alters induction of cytochrome P450 family 1 enzymes.
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Design and rational for the precision medicine guided treatment for cancer pain pragmatic clinical trial.
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Design and synthesis of ?-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation.
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Design and Synthesis of New ?-Naphthoflavones as Cytochrome P450 (CYP) 1B1 Inhibitors To Overcome Docetaxel-Resistance Associated with CYP1B1 Overexpression.
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Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2.
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Design, Synthesis and Binding Affinity Evaluation of Cytochrome P450 1B1 Targeted Chelators.
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Design, Synthesis, and Biological Evaluation of Cytochrome P450 1B1 Targeted Molecular Imaging Probes for Colorectal Tumor Detection.
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Design, synthesis, and enzymatic characterization of quinazoline-based CYP1A2 inhibitors.
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Detection of aromatase and estrogen receptors (ERalpha, ERbeta1, ERbeta2) in human Leydig cell tumor.
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Detection of Cytochrome P450 Polymorphisms in Breast Cancer Patients May Impact on Tamoxifen Therapy
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Detection of three genetic polymorphisms in the 5'-flanking region and intron 1 of human CYP1A2 in the Japanese population.
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Determination of clinically therapeutic endoxifen concentrations based on efficacy from human MCF7 breast cancer xenografts.
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Determination of CYP2D6 *3, *4, and *10 frequency in women with breast cancer in São Luís, Brazil, and its association with prognostic factors and disease-free survival.
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Developing a high-throughput system for the screening of cytochrome P450 1A1--inhibitory polyphenols.
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Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles.
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Development of an estrogen-dependent breast cancer co-culture model as a tool for studying endocrine disruptors.
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Development of benzochalcone derivatives as selective CYP1B1 inhibitors and anticancer agents.
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Developmental regulation and induction of cytochrome P450 2W1, an enzyme expressed in colon tumors.
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Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility--a review.
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Dibenzo[A,L]pyrene-induced genotoxic and carcinogenic responses are dramatically suppressed in aryl hydrocarbon receptor-deficient mice.
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Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.
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Dietary flavonoids in cancer therapy and prevention: substrates and inhibitors of cytochrome P450 CYP1 enzymes.
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Dietary phenethyl isothiocyanate alters gene expression in human breast cancer cells.
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Differences between Spaniards and Ecuadorians in CYP2A6 allele frequencies: comparison with other populations.
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Differences in cytochrome P450 2C19 (CYP2C19) expression in adjacent normal and tumor tissues in Chinese cancer patients.
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Different Dietary Proportions of Fish Oil Regulate Inflammatory Factors but Do Not Change Intestinal Tight Junction ZO-1 Expression in Ethanol-Fed Rats.
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Different h2 receptor antihistamines dissimilarly retard the growth of xenografted human melanoma cells in immunodeficient mice.
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Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs.
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Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.
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Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450.
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Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol.
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Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture.
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Differential effects of flavonoid compounds on tumor promoter-induced activation of the human CYP1A2 enhancer.
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Differential effects of omeprazole and lansoprazole enantiomers on aryl hydrocarbon receptor in human hepatocytes and cell lines.
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Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells.
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Differential expression of cytochrome p450 enzymes in normal and tumor tissues from childhood rhabdomyosarcoma.
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Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma.
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Differential induction of Cyp1a1, Cyp1b1, Ahd4, and Nmo1 in murine skin tumors and adjacent normal epidermis by ligands of the aryl hydrocarbon receptor.
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Differential metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 variants.
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Differential oxidant potential of carcinogenic and weakly carcinogenic estrogens: Involvement of metabolic activation and cytochrome P450.
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Differential regulation of CYP1A1 and CYP1B1 expression in resveratrol-treated human medulloblastoma cells.
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Differential regulation of cytochrome(s) P450 2B1/2 by phenobarbital in hepatic hyperplastic nodules induced by aflatoxin B1 or diethylnitrosamine plus 2-acetylaminofluorene in male F344 rats.
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Differential regulation of multidrug resistance-associated protein 2 (MRP2) and cytochromes P450 2B1/2 and 3A1/2 in phenobarbital-treated hepatocytes.
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Differential responses of sex steroid target tissues of rats treated with 4-hydroxyandrostenedione.
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Differential sensitivity to lung tumorigenesis following transplacental exposure of mice to polycyclic hydrocarbons, heterocyclic amines, and lung tumor promoters.
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Differential vitamin D 24-hydroxylase/CYP24A1 gene promoter methylation in endothelium from benign and malignant human prostate.
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Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm.
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Diminished CYP2E1 expression and formation of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1,1-dichloroethylene epoxide, in murine lung tumors.
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Diminished expression of CYP1A1 in urethane-induced lung tumors in strain A/J mice: analysis by in situ hybridization and immunohistochemical methods.
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Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
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Diosmetin Induces Cell Apoptosis by Regulating CYP1A1/CYP1A2 Due to p53 Activation in HepG2 Cells.
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Direct retroviral delivery of human cytochrome P450 2B6 for gene-directed enzyme prodrug therapy of cancer.
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Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines.
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Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).
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Discovery of heterocycle-containing ?-naphthoflavone derivatives as water-soluble, highly potent and selective CYP1B1 inhibitors.
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Discovery of inhibitors of MCF-7 tumor cell adhesion to endothelial cells and investigation on their mode of action.
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Disparate distribution of 16 candidate single nucleotide polymorphisms among racial and ethnic groups of pediatric heart transplant patients.
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Disposition of desipramine, a sensitive cytochrome P450 2D6 substrate, when coadministered with intravenous temsirolimus.
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Disposition of imatinib and its metabolite CGP74588 in a patient with chronic myelogenous leukemia and short-bowel syndrome.
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Distribution of soluble epoxide hydrolase, cytochrome P450 2C8, 2C9 and 2J2 in human malignant neoplasms.
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Diversified expression of aryl hydrocarbon receptor dependent genes in human laryngeal squamous cell carcinoma cell lines treated with ?-naphthoflavone.
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Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis.
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DMAKO-20 as a new multi-target anticancer prodrug activated by the tumor specific CYP1B1 enzyme.
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DNA damage by 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced p53-mediated apoptosis through activation of cytochrome P450/aryl hydrocarbon receptor.
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DNA methylation and gene expression profiling of ewing sarcoma primary tumors reveal genes that are potential targets of epigenetic inactivation.
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DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung.
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Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional multicentre study.
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Does cytochrome P450 1A1 MspI polymorphism increase acute lymphoblastic leukemia risk? Evidence from 2013 cases and 2903 controls.
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Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver.
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Down-regulation of aryl hydrocarbon receptor-regulated genes by tumor necrosis factor-alpha and lipopolysaccharide in murine hepatoma Hepa 1c1c7 cells.
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Down-regulation of cytochrome P450 1A1 gene promoter by oxidative stress. Critical contribution of nuclear factor 1.
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Down-regulation of hepatic CYP3A1 expression in a rat model of indomethacin-induced small intestinal ulcers.
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Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma.
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Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells.
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Drug interactions and pharmacogenetic factors contribute to variation in apixaban concentration in atrial fibrillation patients in routine care.
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Drug interactions between antineoplastic and antiretroviral therapies: Implications and management for clinical practice.
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Drug-metabolizing enzymes in pharyngeal mucosa and in oropharyngeal cancer tissue.
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Drug-virus interaction: effect of administration of recombinant adenoviruses on the pharmacokinetics of docetaxel in a rat model.
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Dual EGFR and ABL Tyrosine Kinase Inhibitor Treatment in a Patient with Concomitant EGFR-Mutated Lung Adenocarcinoma and BCR-ABL1-Positive CML.
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Dynamic Effects of CYP2D6 Genetic Variants in a Set of Poor Metaboliser Patients with Infiltrating Ductal Cancer Under Treatment with Tamoxifen.
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Dysregulated estrogen receptor signaling in the hypothalamic-pituitary-ovarian axis leads to ovarian epithelial tumorigenesis in mice.
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Dysregulation of Aromatase in Breast, Endometrial, and Ovarian Cancers: An Overview of Therapeutic Strategies.
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Early life exposure to a rodent carcinogen propiconazole fungicide induces oxidative stress and hepatocarcinogenesis in medaka fish.
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Effect of Chinese Herbal Monomer Hairy Calycosin on Nonalcoholic Fatty Liver Rats and its Mechanism.
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Effect of Co-administration of Ketoconazole, a Strong CYP3A Inhibitor, on the Pharmacokinetics, Safety and Tolerability of Navitoclax, a First-in-class Oral Bcl-2 Family Inhibitor, in Cancer Patients.
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Effect of common CYP3A4 and CYP3A5 variants on the pharmacokinetics of the cytochrome P450 3A phenotyping probe midazolam in cancer patients.
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Effect of CYP19 rs6493497 and rs7176005 haplotype status on in vivo aromatase transcription, plasma and tissue estrogen levels in postmenopausal women.
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Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes.
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Effect of CYP3A inhibitors on the pharmacokinetics of pevonedistat in patients with advanced solid tumours.
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Effect of cytochrome P450 inducers on expression of oncogenes and a tumor suppressor gene in human colon cancer cells.
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Effect of dioxin and 17?-estradiol on the expression of cytochrome P450 1A1 gene via an estrogen receptor dependent pathway in cellular and xenografted models.
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Effect of genetic polymorphisms in CYP3A4, CYP3A5, and m-TOR on everolimus blood exposure and clinical outcomes in cancer patients.
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Effect of germ-line genetic variation on breast cancer survival in a population-based study.
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Effect of iron chelator, hydroxyl radical scavenger and cytochrome P450 inhibitors on the cytotoxicity of cisplatin to tumor cells.
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Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in SENCAR mice.
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Effect of polymorphic metabolizing genes on micronucleus frequencies among benzene-exposed shoe workers in China.
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Effect of Pyrethrins on cytochrome P450 forms in cultured rat and human hepatocytes.
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Effect of strain differences and tumor presence on microsomal drug metabolism in the guinea pig: brief communication.
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Effect of thalidomide on endotoxin-induced decreases in activity and expression of hepatic cytochrome P450 3A2.
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Effect of the allelic variants of ABCB1, CYP2D6 and HTR3B on response of ramosetron to prevent chemotherapy-induced nausea and vomiting in Korean cancer patients.
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Effect of the Cytochrome P450 2C19 Inhibitor Omeprazole on the Pharmacokinetics and Safety Profile of Bortezomib in Patients with Advanced Solid Tumours, Non-Hodgkin's Lymphoma or Multiple Myeloma.
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Effect of tumor promoters on induction of aryl hydrocarbon hydroxylase in human lymphocytes.
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Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Tizanidine (a CYP1A2 Substrate) in Patients With BRAFV600 Mutation-Positive Malignancies.
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Effects of 5-methoxypsoralen (5-MOP) on arylamine N-acetyltransferase activity in the stomach and colon of rats and human stomach and colon tumor cell lines.
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Effects of Androgen Receptor Inhibition on Kanamycin-Induced Hearing Loss in Rats.
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Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines.
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Effects of arachidonic acid and indomethacin on sister-chromatid exchange induction by polycyclic aromatic hydrocarbons in mammalian cell lines.
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Effects of artificial sweeteners on the AhR- and GR-dependent CYP1A1 expression in primary human hepatocytes and human cancer cells.
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Effects of baicalein on the pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats: possible role of cytochrome p450 3A4 and P-glycoprotein inhibition by baicalein.
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Effects of beta-carotene supplementation on molecular markers of lung carcinogenesis in male smokers.
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Effects of carbon tetrachloride on oxidative stress, inflammatory response and hepatocyte apoptosis in common carp (Cyprinus carpio).
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Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism.
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Effects of curcumin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen, in rats: possible role of CYP3A4 and P-glycoprotein inhibition by curcumin.
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Effects of cytochrome P450 (CYP) 2A6 gene deletion and CYP2E1 genotypes on gastric adenocarcinoma.
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Effects of cytochrome P450 arachidonic acid epoxygenases on the proliferation of tumor cells.
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Effects of dietary and in vitro 2(3)-t-butyl-4-hydroxy-anisole and other phenols on hepatic enzyme activities in mice.
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Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers.
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Effects of Echinacea purpurea on Hepatic and Renal Toxicity Induced by Diethylnitrosamine in Rats.
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Effects of genetically different strains of mice on the microsomal activation of 2-aminofluorene.
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Effects of human blood levels of two PAH mixtures on the AHR signalling activation pathway and CYP1A1 and COMT target genes in granulosa non-tumor and granulosa tumor cell lines.
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Effects of hypoxia and limited diffusion in tumor cell microenvironment on bystander effect of P450 prodrug therapy.
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Effects of inflammatory cytokine gene polymorphisms on warfarin maintenance doses in Korean patients with mechanical cardiac valves.
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Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats.
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Effects of matrix components on aromatase activity in breast stromal cells in culture.
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Effects of Neonicotinoid Pesticides on Promoter-Specific Aromatase (CYP19) Expression in Hs578t Breast Cancer Cells and the Role of the VEGF Pathway.
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Effects of Oral Anorexiant Sibutramine on the Expression of Cytochromes P450s in Human Hepatocytes and Cancer Cell Lines.
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Effects of polychlorinated dibenzofurans on compounds in hepatic DNA of female Sprague-Dawley rats: structure dependence and mechanistic considerations.
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Effects of ready to drink teas on AhR- and PXR-mediated expression of cytochromes P450 CYP1A1 and CYP3A4 in human cancer cell lines and primary human hepatocytes
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Effects of selenium on chemical carcinogenesis : Comparative effects of antioxidants.
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Effects of the potential chemopreventive agent DMU-135 on adenoma development in the ApcMin+ mouse.
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Effects of Vernonia cinerea Compounds on Drug-metabolizing Cytochrome P450s in Human Liver Microsomes.
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Eicosanoid profiling in an orthotopic model of lung cancer progression by mass spectrometry demonstrates selective production of leukotrienes by inflammatory cells of the microenvironment.
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Eldecalcitol (ED-71), an analog of 1?,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas.
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Elevated levels of the Steroidogenic Factor-1 are associated with over-expression of CYP19 in an Estrogen producing testicular Leydig cell tumour.
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Elimination of major side effects due to ROS of therapeuticals through biotransformation control of the 57 cytochromes P450 isoenzymes.
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Elucidation of CYP2E1 5' regulatory RsaI/Pstl allelic variants and their role in risk for oral cancer.
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Elucidation of molecular targets of mammary cancer chemoprevention in the rat by organoselenium compounds using cDNA microarray.
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Emamectin benzoate induced enzymatic and transcriptional alternation in detoxification mechanism of predatory beetle Paederus fuscipes (Coleoptera: Staphylinidae) at the sublethal concentration.
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Embryonic atrazine exposure elicits proteomic, behavioral, and brain abnormalities with developmental time specific gene expression signatures.
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Enantioselective metabolism and cytotoxicity of R-Ifosfamide and S-Ifosfamide by tumor cell-expressed cytochromes P450.
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Enantioselectivity in the cytochrome P450-dependent conversion of tegafur to 5-fluorouracil in human liver microsomes.
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Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy and are safe and efficacious: data from two clinical trials in pancreatic cancer.
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Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond.
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Engineered mesenchymal stem cells as vectors in a suicide gene therapy against preclinical murine models for solid tumors.
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Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediation.
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Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11.
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Enhanced bystander cytotoxicity of P450 gene-directed enzyme prodrug therapy by expression of the antiapoptotic factor p35.
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Enhanced cancer growth in mice administered daily human-equivalent doses of some H1-antihistamines: predictive in vitro correlates.
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Enhanced decomposition of oxyferrous cytochrome P450CIA1 (P450cam) by the chemopreventive agent 3-t-butyl-4-hydroxyanisole.
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Enhanced induction of cytochrome P450 enzymes and CAR binding in TNF (p55(-/-)/p75(-/-)) double receptor knockout mice following phenobarbital treatment.
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Enhanced liver tumor promotion but not liver initiation activity in rats subjected to combined administration of omeprazole and ?-naphthoflavone.
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Enhancement of hepatocarcinogenesis and induction of specific cytochrome P450-dependent monooxygenase activities by the barbiturates allobarbital, aprobarbital, pentobarbital, secobarbital and 5-phenyl- and 5-ethylbarbituric acids.
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Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model.
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Enhancer elements in the mouse CYP1A2 gene: a comparative sequencing among different inbred mouse strains.
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Environmental tobacco smoke, genetic susceptibility, and risk of lung cancer in never-smoking women.
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Enzymes Oxidizing the Azo Dye 1-Phenylazo-2-Naphthol (Sudan I) and their Contribution to its Genotoxicity and Carcinogenicity.
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Enzymic and interindividual differences in the human metabolism of heterocyclic amines.
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Epigenetic inactivation of the dioxin-responsive cytochrome P4501A1 gene in human prostate cancer.
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Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity.
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Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression.
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Epoxyeicosatrienoic Acids Attenuate Reactive Oxygen Species level, Mitochondrial Dysfunction, Caspase Activation and Apoptosis in Carcinoma Cells Treated with Arsenic Trioxide.
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ER? phenotype, estrogen level, and benzo[a]pyrene exposure modulate tumor growth and metabolism of lung adenocarcinoma cells.
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ERCC1 and CYP1B1 polymorphisms as predictors of response to neoadjuvant chemotherapy in estrogen positive breast tumors.
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Estradiol 17? and Its Metabolites Stimulate Cell Proliferation and Antagonize Ascorbic Acid-Suppressed Cell Proliferation in Human Ovarian Cancer Cells.
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Estradiol-mediated suppression of CYP1B1 expression in mouse MA-10 Leydig cells is independent of protein kinase A and estrogen receptor.
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Estrogen receptor alpha promotes smoking-carcinogen-induced lung carcinogenesis via cytochrome P450 1B1.
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Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk.
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Ethnic and genetic differences in metabolism genes and risk of toxicity and cancer.
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Ethnic variation in the CYP2E1 gene: polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese.
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Ethnic-related differences in the frequency distribution of genetic polymorphisms in the CYP1A1 and CYP1B1 genes in Japanese and Caucasian populations.
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Evaluation of a real-time polymerase chain reaction method for the quantification of CYP1B1 gene expression in MCF-7 human breast carcinoma cells.
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Evaluation of CYP1A1 and CYP2B1/2 m-RNA induction in rat liver slices using the NanoString technology: a novel tool for drug discovery lead optimization.
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Evaluation of Drug-Drug Interactions of Rucaparib and CYP1A2, CYP2C9, CYP2C19, CYP3A, and P-gp Substrates in Patients With an Advanced Solid Tumor.
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Evaluation of the Effects of Repeat-Dose Dabrafenib on the Single-Dose Pharmacokinetics of Rosuvastatin (OATP1B1/1B3 Substrate) and Midazolam (CYP3A4 Substrate).
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Evaluation of the likelihood of a selective CHK1 inhibitor (LY2603618) to inhibit CYP2D6 with desipramine as a probe substrate in cancer patients.
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Evaluation of the pharmacokinetic drug interaction potential of tivantinib (ARQ 197) using cocktail probes in patients with advanced solid tumours.
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Everolimus-induced nephrotic syndrome precipitated by interaction with voriconazole in a patient with Hodgkin's lymphoma.
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Evidence of a genetic relationship between susceptibility to 3-methyl-cholanthrene-induced subcutaneous tumors and inducibility of aryl hydrocarbon hydroxylase.
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Evidence of gene gene interactions in lung carcinogenesis in a large pooled analysis.
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Evidence that genetic variants of metabolic detoxication and cell cycle control are not related to gallbladder cancer risk in Chilean women.
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Exhaled breath and oral cavity VOCs as potential biomarkers in oral cancer patients.
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Expanding the view of breast cancer metabolism: Promising molecular targets and therapeutic opportunities.
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Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene.
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Exploring the relationship between lifestyles, diets and genetic adaptations in humans.
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Exposure of human skin to benzo[a]pyrene: Role of CYP1A1 and aryl hydrocarbon receptor in oxidative stress generation.
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Expression and chromosomal localization of the cytochrome P1-450 gene in human mitogen-stimulated lymphocytes.
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Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors.
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Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines.
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Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis.
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Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas.
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Expression of CYP1C1 and CYP1A in Fundulus heteroclitus during PAH-induced carcinogenesis.
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Expression of cytochrome P 450 3A enzymes in human lung: a combined RT-PCR and immunohistochemical analysis of normal tissue and lung tumours.
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Expression of cytochrome P450 1B1 and catechol-O-methyltransferase in breast tissue and their associations with breast cancer risk.
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Expression of cytochrome P450 arachidonic acid epoxygenase 2J2 in human tumor tissues and cell lines.
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Expression of cytochrome P450 genes in CD34+ hematopoietic stem and progenitor cells.
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Expression of cytochrome P450 in tumor tissues and its association with cancer development.
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Expression of cytochrome P4502E1 in human liver: Relationship between genotype and phenotype in Chinese.
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Expression of cytochromes P450 3A and P-glycoprotein in human large intestine in paired tumour and normal samples.
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Expression of Genes for Methylxanthine Pathway-Associated Enzymes Accompanied by Sex Steroid Receptor Status Impacts Breast Carcinoma Progression.
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Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue.
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Expression of glutathione S-transferases in fetal lung and liver tissue from parental strains and F1 crosses between C57BL/6 and BALB/c F1 mice following in utero exposure to 3-methylcholanthrene.
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Expression of P450 Aromatase in Granulosa Cell Tumors and Sertoli-Stromal Cell Tumors of the Ovary: Which Cells Are Responsible for Estrogenesis?
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Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy.
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Expression of the aryl hydrocarbon receptor pathway and cyclooxygenase-2 in dog tumors.
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Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis.
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Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death.
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Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer.
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Expression of two cytochromes P450 involved in carcinogen activation in a human colon cell line.
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Expression of xenobiotic and steroid hormone metabolizing enzymes in human breast carcinomas.
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Expression of xenobiotic-metabolizing enzymes by primary and secondary hepatic tumors in man.
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Expression Patterns of Xenobiotic-Metabolizing Enzymes in Tumor and Adjacent Normal Mucosa Tissues among Patients with Colorectal Cancer: The ColoCare Study.
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Expression profiling of CYP1B1 in oral squamous cell carcinoma: counterintuitive downregulation in tumors.
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Expressions of cytochrome P450, UDP-glucuronosyltranferase, and transporter genes in monolayer carcinoma cells change in subcutaneous tumors grown as xenografts in immunodeficient nude mice.
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Extra-hepatic isozymes from the CYP1 and CYP2 families as potential chemotherapeutic targets.
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Features of the Copy Number Variation of Certain Genes in Tumor Cells in Patients with Serous Ovarian Adenocarcinoma.
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Fetal mouse Cyp1b1 and transplacental carcinogenesis from maternal exposure to dibenzo(a,l)pyrene.
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Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.
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Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells.
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Formation of a novel topotecan metabolite in the hormone-independent human prostate carcinoma cell lines DU-145 and PC-3.
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Forskolin up-regulates aromatase (CYP19) activity and gene transcripts in the human adrenocortical carcinoma cell line H295R.
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FOXO1 Negates the Cooperative Action of FOXL2C134W and SMAD3 in CYP19 Expression in HGrC1 Cells by Sequestering SMAD3.
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Frequencies of poor metabolizers of cytochrome P450 2C19 in esophagus cancer, stomach cancer, lung cancer and bladder cancer in Chinese population.
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Frequency of common CYP1B1 polymorphic variations in Delhi population of Northern India.
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Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population.
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Frequency of the functionally relevant aryl hydrocarbon receptor repressor (AhRR) Pro185Ala SNP in Papua New Guinea.
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Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy.
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Functional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation Activities.
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Functional characterization of the human CYP1A1 negative regulatory element: modulation of Ah receptor mediated transcriptional activity.
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Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors.
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Functional polymorphisms in the CYP2C19 gene contribute to digestive system cancer risk: evidence from 11,042 subjects.
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Functional PstI/RsaI Polymorphism in CYP2E1 Is Associated with the Development, Progression and Poor Outcome of Gastric Cancer.
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Functional PstI/RsaI Polymorphisms in the CYP2E1 Gene among South Indian Populations.
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Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer.
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Functionally active duplications of the CYP2D6 gene are more prevalent among larynx and lung cancer patients.
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Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.
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Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling.
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Future prospects of personalized chemotherapy in gastric cancer patients: results of a prospective randomized pilot study.
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Gene expression analysis on the dicyclanil-induced hepatocellular tumors in mice.
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Gene Expression of CYP1A1 and its Possible Clinical Application in Thyroid Cancer Cases.
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Gene expression of vitamin D metabolic enzymes at baseline and in response to vitamin D treatment in thyroid cancer cell lines.
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Gene expression profiles of CYP24A1 and CYP27B1 in malignant and normal breast tissues.
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Gene therapy for malignant gliomas using replication incompetent retroviral and adenoviral vectors encoding the cytochrome P450 2B1 gene together with cyclophosphamide.
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Gene variants associated with acne vulgaris presentation and severity: a systematic review and meta-analysis.
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Gene-environment interactions associated with CYP1A1 MspI and GST polymorphisms and the risk of upper aerodigestive tract cancers in an Indian population.
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Gene-environment interactions in determining differences in genetic susceptibility to cancer in subsites of the head and neck.
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Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes.
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Genetic analysis of colon tumors induced by a dietary carcinogen PhIP in CYP1A humanized mice: Identification of mutation of ?-catenin/Ctnnb1 as the driver gene for the carcinogenesis.
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Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone.
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Genetic Association of CYP1B1 4326 C>G Polymorphism with Disease-Free Survival in TNBC Patients Undergoing TAC Chemotherapy Regimen.
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Genetic associations between CYP24A1 polymorphisms and predisposition of cancer: A meta-analysis.
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Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
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Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia.
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Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzle.
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Genetic network and gene set enrichment analysis to identify biomarkers related to cigarette smoking and lung cancer.
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Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): Population distribution of CYP2D6 activity.
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Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers.
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Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk.
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Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers.
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Genetic polymorphism of CYP2D6 influences susceptibility to papillary thyroid cancer.
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Genetic polymorphism of CYP2D6, GSTM1 and NAT2 and susceptibility to haematological neoplasias.
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Genetic polymorphism of cytochrome P450 1A1 (Cyp1A1) and glutathione transferases (M1, T1 and P1) among Africans.
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Genetic polymorphism of cytochromes P450 1A1, 2D6 and 2E1: regulation and toxicological significance.
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Genetic polymorphism of cytochromes P450: interethnic differences and relationship to incidence of lung cancer.
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Genetic polymorphism of drug metabolizing enzymes (CYP2E1, GSTP1) and susceptibility to bladder cancer in North India.
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Genetic polymorphism of drug metabolizing enzymes (GSTM1 and CYP1A1) as risk factors for oral premalignant lesions and oral cancer.
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Genetic polymorphism of drug-metabolizing enzymes and susceptibility to oral cancer.
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Genetic polymorphism of estrogen metabolizing enzymes in siberian women with breast cancer.
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Genetic polymorphism of GSTM1, CYP2E1 and CYP2D6 in Egyptian bladder cancer patients.
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Genetic polymorphism of metabolic enzymes P450 (CYP) as a susceptibility factor for drug response, toxicity, and cancer risk.
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Genetic polymorphism of xenobiotic metabolising enzymes in Slovenian lung cancer patients.
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Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population.
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Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review).
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Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer.
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Genetic polymorphisms in ABCG2 and CYP1A2 are associated with imatinib dose reduction in patients treated for gastrointestinal stromal tumors.
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Genetic polymorphisms in CYP3A5, CYP3A4 and NQO1 in children who developed therapy-related myeloid malignancies.
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Genetic polymorphisms in human xenobiotica metabolizing enzymes as susceptibility factors in toxic response.
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Genetic polymorphisms in promoter and intronic regions of CYP1A2 gene in Roma and Hungarian population samples.
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Genetic polymorphisms in the cytochrome P450 1A1, glutathione S-transferase M1 and T1, and susceptibility to colon cancer.
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Genetic polymorphisms in the vitamin D pathway in relation to lung cancer risk and survival.
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Genetic polymorphisms of CYP1A1, GSTM1 and P53 genes in a unique Siberian population of Tundra Nentsi and its pharmacogenetic importance.
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Genetic polymorphisms of CYP2B6 affect the pharmacokinetics/pharmacodynamics of cyclophosphamide in Japanese cancer patients.
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Genetic Polymorphisms of CYP2D6 Oxidation in Patients with Inflammatory Bowel Disease.
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Genetic polymorphisms of CYP2D6, GSTM1, and GSTT1 genes and bladder cancer risk in North India.
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Genetic polymorphisms of CYP2E1 and DNA repair genes HOGG1 and XRCC1: Association with hepatitis B related advanced liver disease and cancer.
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Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India.
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Genetic polymorphisms of cytochrome P450 in patients with hepatitis C virus-associated hepatocellular carcinoma.
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Genetic polymorphisms of cytochrome P4501A1 and oesophageal squamous-cell carcinoma in Taiwan.
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Genetic polymorphisms of human cytochrome P450 CYP1A1 in an Egyptian population and tobacco-induced lung cancer.
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Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer.
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Genetic sequence variants in vitamin D metabolism pathway genes, serum vitamin D level and outcome in head and neck cancer patients.
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Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: a study on host factors in relation to age at onset, gender and histological cancer types.
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Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients.
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Genetic variants of CYP2D6 gene and cancer risk: a HuGE systematic review and meta-analysis.
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Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia.
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Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish women.
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Genetically modified macrophages expressing hypoxia regulated cytochrome P450 and P450 reductase for the treatment of cancer.
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Genetics of CYP1A1: coamplification of specific alleles by polymerase chain reaction and association with breast cancer.
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Genetics of susceptibility of mice to inhibition of interferon induction by benzo-(a)-pyrene.
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Genistein affects expression of cytochrome P450 (CYP450) genes in hepatocellular carcinoma (HEPG2/C3A) cell line.
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Genistein decreases basal hepatic cytochrome P450 1A1 protein expression and activity in Swiss Webster mice.
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Genistein-induced changes in gene expression in Panc 1 cells at physiological concentrations of genistein.
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Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.
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Genomic Sequencing of Cancer-related Genes in Sinonasal Squamous Cell Carcinoma and Coexisting Inverted Papilloma.
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Genotoxic and inflammatory effects of organic extracts from traffic-related particulate matter in human lung epithelial A549 cells: The role of quinones.
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Genotype of Null Polymorphisms in Genes GSTM1, GSTT1, CYP1A1, and CYP1A1*2A (rs4646903 T>C)/CYP1A1*2C (rs1048943 A>G) in Patients with Larynx Cancer in Southeast Spain.
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Genotype/phenotype comparisons: a probe for the effect of disease progression on drug metabolism.
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Genotypes for the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human longevitY. Role of CYP2D6 and CYP2C19 in longevity.
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Genotyping of the CYP1A1 and GSTM1 genes in esophageal carcinoma patients with special reference to smoking.
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Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: associations with tumor progression, age and human papillomavirus infection.
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Ginkgo biloba extract EGb 761-mediated inhibition of aromatase for the treatment of hormone-dependent breast cancer.
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Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis.
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Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis.
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Glutathione S-Transferases and Cytochrome P450 Enzyme Expression in Patients with Intracranial Tumors: Preliminary Report of 55 Patients.
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Glutathione-S-transferase M1 and T1 and cytochrome P1A1 genetic polymorphisms and susceptibility to cervical intraepithelial neoplasia in Greek women.
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GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer.
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Growth and characterization of N-methyl-N-nitrosourea-induced mammary tumors in intact and ovariectomized rats.
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GSTM1 and CYP2D6 genotype frequencies in patients with pituitary tumours: effects on P53, ras and gsp.
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GSTM1 enzyme concentration and enzyme activity in correlation to the genotype of detoxification enzymes in squamous cell carcinoma of the oral cavity.
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GSTT1, GSTM1, and CYP1B1 gene polymorphisms and susceptibility to sporadic renal cell cancer.
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Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.
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Has the era of individualised medicine arrived for antifungals? A review of antifungal pharmacogenomics.
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Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.
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Helicobacter hepaticus-Induced Liver Tumor Promotion Is Associated with Increased Serum Bile Acid and a Persistent Microbial-Induced Immune Response.
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Helicobacter pylori infection, but not genetic polymorphism of CYP2E1, is highly prevalent in gastric cancer patients younger than 40 years.
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Hepatic CYP1A2 activity in liver tumors and the implications for preoperative volume-function analysis.
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Hepatic cytochrome P450 3A drug metabolism is reduced in cancer patients who have an acute-phase response.
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Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.
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Hepatic cytochrome P450 gene regulation during endotoxin-induced inflammation in nuclear receptor knockout mice.
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Hepatitis B virus downregulates vitamin D receptor levels in hepatoma cell lines, thereby preventing vitamin D-dependent inhibition of viral transcription and production.
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Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells.
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Hepatocellular carcinoma: gene expression profiling and regulation of xenobiotic-metabolizing cytochromes P450.
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Hepatoprotective effect of gastrodin against alcohol-induced liver injury in mice.
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Hepatoprotective effect of methylsulfonylmethane against carbon tetrachloride-induced acute liver injury in rats.
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Hepatoprotective effects of hoveniae semen cum fructus extracts in ethanol intoxicated mice.
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Hepatoprotective Effects of Steamed and Freeze-Dried Mature Silkworm Larval Powder against Ethanol-Induced Fatty Liver Disease in Rats.
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Hepatotoxicity prevention in Acetaminophen-induced HepG2 cells by red betel (Piper crocatum Ruiz and Pav) extract from Indonesia via antioxidant, anti-inflammatory, and anti-necrotic.
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Hereditary Hypercalcemia Caused by a Homozygous Pathogenic Variant in the CYP24A1 Gene: A Case Report and Review of the Literature.
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Heterologous expression of human cytochrome P450 2S1 in Escherichia coli and investigation of its role in metabolism of benzo[a]pyrene and ellipticine.
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High Coffee Intake, but Not Caffeine, is Associated with Reduced Estrogen Receptor Negative and Postmenopausal Breast Cancer Risk with No Effect Modification by CYP1A2 Genotype.
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High dose lycopene supplementation increases hepatic cytochrome P4502E1 protein and inflammation in alcohol-fed rats.
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High TGFbeta1, estrogen receptor, and aromatase gene expression in a large cell calcifying sertoli cell tumor (LCCSCT): implications for the mechanism of oncogenesis.
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High-throughput evaluation of CYP1A1 and 2B1 induction in rat liver slices using a semi-automated system.
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Higher CYP2E1 Activity Correlates with Hepatocarcinogenesis Induced by Diethylnitrosamine.
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Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells.
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Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of human cytochrome P450 CYP2D6 gene.
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Host determinants of DNA alkylation and DNA repair activity in human colorectal tissue: O(6)-methylguanine levels are associated with GSTT1 genotype and O(6)-alkylguanine-DNA alkyltransferase activity with CYP2D6 genotype.
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Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin.
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Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.
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Human CYP1B1 and anticancer agent metabolism: mechanism for tumor-specific drug inactivation?
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Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid.
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Human Cytochrome P450 2E1 Mutations that Alter Mitochondrial Targeting Efficiency and Susceptibility to Ethanol-induced Toxicity in Cellular Models.
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Human Cytochrome P450 2W1 Is Not Expressed in Adrenal Cortex and Is Only Rarely Expressed in Adrenocortical Carcinomas.
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Human cytochrome P450 liability studies of trans-dihydronarciclasine: a readily available, potent, and selective cancer cell growth inhibitor.
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Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls.
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Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription.
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Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.
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Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo.
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Human relevance framework for rodent liver tumors induced by the insecticide sulfoxaflor.
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Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators.
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Hyperglycemic Ins2AkitaLdlr-/- mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease.
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Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation.
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Hyperlipidemia exacerbates cerebral injury through oxidative stress, inflammation and neuronal apoptosis in MCAO/reperfusion rats.
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Hypermethylation of carcinogen metabolism genes, CYP1A1, CYP2A13 and GSTM1 genes in head and neck cancer.
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Hypopharyngeal cancer risk in Japanese: Genetic polymorphisms related to the metabolism of alcohol- and tobacco-associated carcinogens.
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Hypoxia as a modulator of cytochromes P450: Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia.
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Iatrogenic vitamin D toxicity in an infant - a case report and review of literature.
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Identification of 19-(S/R)Hydroxyeicosatetraenoic Acid as the First Endogenous Noncompetitive Inhibitor of Cytochrome P450 1B1 with Enantioselective Activity.
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Identification of a less toxic vinca alkaloid derivative for use as a chemotherapeutic agent, based on in silico structural insights and metabolic interactions with CYP3A4 and CYP3A5.
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Identification of biomarkers predicting the chemotherapeutic outcomes of capecitabine and oxaliplatin in patients with gastric cancer.
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Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families.
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Identification of CYP1B1-specific candidate inhibitors using combination of in silico screening, integrated knowledge-based filtering, and molecular dynamics simulations.
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Identification of genetic variations associated with drug resistance in non-small cell lung cancer patients undergoing systemic treatment.
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Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository.
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Identification of key genes in endometrioid endometrial adenocarcinoma via TCGA database.
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Identification of leads for antiproliferative activity on MDA-MB-435 human breast cancer cells through pharmacophore and CYP1A1-mediated metabolism.
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Identification of PGRMC1 as a Candidate Oncogene for Head and Neck Cancers and Its Involvement in Metabolic Activities.
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Identification of Potent and Selective CYP1A1 Inhibitors via Combined Ligand and Structure-Based Virtual Screening and Their in Vitro Validation in Sacchrosomes and Live Human Cells.
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Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1.
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Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.
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Immortalized human corneal epithelial cells for ocular toxicity and inflammation studies.
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Immunoglobulin light chain, Blimp-1 and cytochrome P4501B1 peptides as potential vaccines for AL amyloidosis.
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Immunohistochemical demonstration of the expression of CYP2E1 in human breast tumour and non-tumour tissues.
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Immunohistochemical detection of CYP2E1 and 2-S-glutathionyl acetate in murine lung tumors: diminished formation of reactive intermediates of 1,1-dichloroethylene.
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Immunohistochemical evaluation of cytochrome P450 (CYP) and p53 in breast cancer.
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Immunohistochemical localization of cytochrome P450 2E1 in human pulmonary carcinoma and normal bronchial tissue.
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Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1.
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Immunohistochemical studies of steroidogenic enzymes (aromatase, 17 alpha-hydroxylase and cholesterol side-chain cleavage cytochromes P-450) in sex cord-stromal tumors of the ovary.
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Immunohistochemical study of CYP2E1 in hepatocellular carcinoma carcinogenesis: examination with newly prepared anti-human CYP2E1 antibody.
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Immunolocalization of aromatase P-450 in ovarian tissue from pregnant and nonpregnant mares and in ovarian tumours.
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Immunopharmacology 2011: an updated report of clinical achievements and perspectives.
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Immunosuppressive effects of 3-methylcholanthrene given intratracheally in various inbred strains of mice.
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Impact of AhR, CYP1A1 and GSTM1 genetic polymorphisms on TP53 R273G mutations in individuals exposed to polycyclic aromatic hydrocarbons.
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Impact of Alternaria toxins on CYP1A1 expression in different human tumor cells and relevance for genotoxicity.
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Impact of CYP genotype and inflammatory markers on the plasma concentrations of tramadol and its demethylated metabolites and drug tolerability in cancer patients.
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Impact of CYP1A1, GSTM1, and GSTT1 polymorphisms in overall and specific prostate cancer survival.
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Impact of CYP24A1 overexpression on growth of colorectal tumour xenografts in mice fed with vitamin D and soy.
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Impact of CYP2D6 Pharmacogenomic Status on Pain Control Among Opioid-Treated Oncology Patients.
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Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy.
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Impact of CYP3A5 and ABCB1 Gene Polymorphisms on Fentanyl Pharmacokinetics and Clinical Responses in Cancer Patients Undergoing Conversion to a Transdermal System.
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Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies.
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Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China.
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Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrome P450-based cancer gene therapy model.
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Impacts of Cytochrome P450 2D6 (CYP2D6) Genetic Polymorphism in Tamoxifen Therapy for Breast Cancer.
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Impaired cholesterol metabolism in the mouse model of cystic fibrosis. A preliminary study.
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Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy.
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Impaired tamoxifen metabolism reduces survival in familial breast cancer patients.
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Impaired Vitamin D Signaling Is Associated With Frequent Development of Renal Cell Tumor in End-stage Kidney Disease.
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Implications of cytochrome P450 genetic polymorphisms on the toxicity of antitumor agents.
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Importance of CYP1A1 polymorphism and its transcriptional regulation in ovarian and endometrial cancer.
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Important role of CYP2J2 in protein kinase inhibitor degradation: a possible role in intratumor drug disposition and resistance.
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Improvement of cyclophosphamide activation by CYP2B6 mutants: from in silico to ex vivo.
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In silico and biochemical analyses identify quinone reductase 2 as a target of piceatannol.
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In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.
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In silico identification and screening of CYP24A1 inhibitors: 3D QSAR pharmacophore mapping and molecular dynamics analysis.
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In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide.
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In silico screening and analysis of nonsynonymous SNPs in human CYP1A2 to assess possible associations with pathogenicity and cancer susceptibility.
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In vitro and in vivo primate evaluation of carbon-11-etomidate and carbon-11-metomidate as potential tracers for PET imaging of the adrenal cortex and its tumors.
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In Vitro and In Vivo Study on the Toxic Effects of Propiconazole Fungicide in the Pathogenesis of Liver Fibrosis.
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In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin.
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In vitro assessment of inhibition by natural polyphenols of metabolic activation of procarcinogens by human CYP1A1.
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In vitro biotransformation and genotoxicity of the drinking water disinfection byproduct bromodichloromethane: DNA binding mediated by glutathione transferase theta 1-1.
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In vitro cancer chemopreventive properties of polysaccharide extract from the brown alga, Sargassum latifolium.
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In vitro inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced activity by alpha-naphthoflavone and 6-methyl-1,3,8-trichlorodibenzofuran using an aryl hydrocarbon (Ah)-responsive construct.
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In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus.
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In vitro inhibitory effects of ganoderic acid A on human liver cytochrome P450 enzymes.
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In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility.
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In vitro metabolism of aflatoxin B1 by normal and tumorous liver tissue from Thailand.
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In vitro prostaglandin H synthase- and monooxygenase-mediated binding of aflatoxin B1 to DNA in guinea-pig tissue microsomes.
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In vivo effect of molybdenum on benzo(a)pyrene metabolism in liver and lung rat microsomes.
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In-depth proteome analysis of the rubber particle of Hevea brasiliensis (para rubber tree).
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Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer.
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Increased CYP24A1 expression is associated with BRAF(V600E) mutation and advanced stages in papillary thyroid carcinoma.
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Increased expression of CYP24A1 correlates with advanced stages of prostate cancer and can cause resistance to vitamin D3-based therapies.
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Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer.
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Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats.
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Individualization of cancer therapy based on cytochrome P450 polymorphism: a pharmacogenetic approach.
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Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I).
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Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction.
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Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol.
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Induction of apoptosis by a stilbene analog involves Bax translocation regulated by p38 MAPK and Akt.
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Induction of aryl hydrocarbon hydroxylase and forestomach tumors ben benzo(a)pyrene.
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Induction of aryl hydrocarbon hydroxylase in mouse tissues from a high and low cancer strain and their F 1 hybrids.
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Induction of cyclooxygenase-2 by tumor promoters in transformed and cytochrome P450 2E1-expressing hepatocytes.
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Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity.
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Induction of cytochrome P-450 1A1 by omeprazole in human HepG2 cells is protein tyrosine kinase-dependent and is not inhibited by alpha-naphthoflavone.
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Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage.
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Induction of fibroblast growth factor-9 and interleukin-1alpha gene expression by motorcycle exhaust particulate extracts and benzo(a)pyrene in human lung adenocarcinoma cells.
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Induction of mono-oxygenase activity in prostaglandin H synthase-competent ovine seminal vesicle cell cultures by 2,3,7,8-Tetrachlorodibenzo-p-dioxin.
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Induction of mutations in Ki-ras and INK4a in liver tumors of mice exposed in utero to 3-methylcholanthrene.
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Induction via Functional Protein Stabilization of Hepatic Cytochromes P450 upon gp78/Autocrine Motility Factor Receptor (AMFR) Ubiquitin E3-ligase Genetic Ablation in Mice: Therapeutic and Toxicological Relevance.
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Infection with carcinogenic helminth parasites and its production of metabolites induces the formation of DNA-adducts.
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Inflammation-induced phenoconversion of polymorphic drug metabolizing enzymes: hypothesis with implications for personalized medicine.
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Inflammatory breast cancer: Activation of the aryl hydrocarbon receptor and its target CYP1B1 correlates closely with Wnt5a/b-?-catenin signalling, the stem cell phenotype and disease progression.
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Influence of antioxidants and the CYP1A1 isoleucine to valine polymorphism on the smoking--lung cancer association.
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Influence of arylamine N-acetyltransferase, sex, and age on 4-aminobiphenyl-induced in vivo mutant frequencies and spectra in mouse liver.
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Influence of beta-naphthoflavone on 7,12-dimethylbenz(a)anthracene metabolism, DNA adduction, and tumorigenicity in rainbow trout.
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Influence of CYP2C8 polymorphisms on imatinib steady-state trough level in chronic myeloid leukemia and gastrointestinal stromal tumor patients.
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Influence of Cytochrome P450, ABC and SLC Gene Polymorphisms on Imatinib Therapy Outcome of Patients with Gastrointestinal Stromal Tumours (GIST).
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Influence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and disease.
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Influence of the Cyp1B1 L432V gene polymorphism and exposure to tobacco smoke on Cyp1B1 mRNA expression in human leucocytes.
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Inhibin and activin differentially regulate androgen production and 17 alpha-hydroxylase expression in human ovarian thecal-like tumor cells.
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Inhibition of 17?-estradiol activation by CYP1A1: Genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols.
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Inhibition of 3-methylcholanthrene-induced skin tumorigenicity in BALB/c mice by chronic oral feeding of trace amounts of ellagic acid in drinking water.
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Inhibition of aldose reductase ameliorates alcoholic liver disease by activating AMPK and modulating oxidative stress and inflammatory cytokines.
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Inhibition of apoptosis in rat hepatocytes treated with 'non-dioxin-like' polychlorinated biphenyls.
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Inhibition of aromatase activity and of endocrine-responsive tumor growth by 10-propargylestr-4-ene-3, 17-dione and its 17-propionate derivative.
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Inhibition of calcitriol inactivating enzyme CYP24A1 gene expression by flavonoids in hepatocellular carcinoma cells under normoxia and hypoxia.
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Inhibition of Carcinogen-Activating Cytochrome P450 Enzymes by Xenobiotic Chemicals in Relation to Antimutagenicity and Anticarcinogenicity.
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Inhibition of estrogen-induced kidney carcinogenesis in Syrian hamsters by modulators of estrogen metabolism.
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Inhibition of glutathione S-transferase P1-1 in mouse lung epithelial cells by the tumor promoter 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone (BHT-quinone methide): protein adducts investigated by electrospray mass spectrometry.
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Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC-MS/MS method for the analysis of estradiol product formation.
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Inhibition of rat hepatic CYP2E1 by quinacrine: molecular modeling investigation and effects on 4-(methyl nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced mutagenicity.
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Inhibition of rat liver cytochrome P450 isozymes by isothiocyanates and their conjugates: a structure-activity relationship study.
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Inhibitors and Prodrugs Targeting CYP1: a Novel Approach in Cancer Prevention and Therapy.
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Inhibitory Effect of 5-Fluorouracil on Cytochrome P450 2C9 Activity in Cancer Patients.
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Inhibitory effect of soluble EP2 receptor on ovarian tumor growth in nude mice and utility of TMPRSS4 as a combinatorial molecular target.
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Inhibitory effect of TMK688 on skin tumor initiation caused by 7,12-dimethylbenz[a]anthracene in relation to inhibition of aryl hydrocarbon hydroxylase activity and Cyp1a1 mRNA induction.
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Inhibitory effects of chrysoeriol on DNA adduct formation with benzo[a]pyrene in MCF-7 breast cancer cells.
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Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075).
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Injection of encapsulated cells producing an ifosfamide-activating cytochrome P450 for targeted chemotherapy to pancreatic tumors.
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Inoculation of human tumor cells alters the basal expression but not the inducibility of Cyp enzymes in tumor-bearing mouse liver.
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Integrated Proteomics and Bioinformatics to Identify Potential Prognostic Biomarkers in Hepatocellular Carcinoma.
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Inter-ethnic differences in genetic polymorphisms of xenobiotic-metabolizing enzymes (CYP1A1, CYP2D6, NAT1 and NAT2) in healthy populations: correlation with the functional in silico prediction.
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Interaction between CYP 2C19*3 polymorphism and smoking in relation to laryngeal carcinoma in the Chinese Han population.
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Interaction between cytochrome P-450 2E1 polymorphisms and environmental factors with risk of esophageal and stomach cancers in Chinese.
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Interaction between dietary acrylamide intake and genetic variants for estrogen receptor-positive breast cancer risk.
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Interaction between smoking history and gene expression levels impacts survival of breast cancer patients.
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Interaction of cytochrome P4501A1 genotypes with other risk factors and susceptibility to lung cancer.
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Interaction of heterogeneous nuclear ribonucleoprotein A1 with cytochrome P450 2A6 mRNA: implications for post-transcriptional regulation of the CYP2A6 gene.
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Interaction of N-(2-Hydroxypropyl)methacrylamide Copolymer-Doxorubicin Conjugates with Human Liver Microsomal Cytochromes P450: Comparison with Free Doxorubicin.
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Interactions between prostaglandin E(2), liver receptor homologue-1, and aromatase in breast cancer.
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Interactions of Alectinib with Human ATP-Binding Cassette Drug Efflux Transporters and Cytochrome P450 Biotransformation Enzymes: Effect on Pharmacokinetic Multidrug Resistance.
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Interactions of renal cytochrome P450 (CYP), angiotensin (AII) and tumor necrosis factor-alpha (TNF): implications for ion transport.
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Interest and attitudes of patients, cancer physicians, medical students and cancer researchers towards a spectrum of genetic tests relevant to breast cancer patients.
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Interindividual differences in nicotine metabolism and genetic polymorphisms of human CYP2A6.
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Interindividual variations in aprepitant plasma pharmacokinetics in cancer patients receiving cisplatin-based chemotherapy for the first time.
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Interleukin-1? and tumor necrosis factor-? affect cytochrome P450 expression in cynomolgus macaque hepatocytes.
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Interleukin-1alpha and tumor necrosis factor alpha modulate cytochrome P450 activities in carp (Cyprinus carpio).
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Interleukin-1beta, interleukin-6, tumour necrosis factor-alpha and interferon-gamma released by a viral infection and an aseptic inflammation reduce CYP1A1, 1A2 and 3A6 expression in rabbit hepatocytes.
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Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3.
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Interleukins-12 and -23 do not alter expression or activity of multiple cytochrome p450 enzymes in cryopreserved human hepatocytes.
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Interstrain differences in susceptibility to liver carcinogenesis initiated by N-nitrosodiethylamine and its promotion by phenobarbital in C57BL/6NCr, C3H/HeNCrMTV- and DBA/2NCr mice.
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Intratumoral activation of cyclophosphamide by retroviral transfer of the cytochrome P450 2B1 in a pancreatic tumor model. Combination with the HSVtk/GCV system.
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Intratumoral Sterol-27-Hydroxylase (CYP27A1) Expression in Relation to Cholesterol Synthesis and Vitamin D Signaling and Its Association with Lethal Prostate Cancer.
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Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies.
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Intrinsic hepatic phenotype associated with the Cyp1a2 gene as shown by cDNA expression microarray analysis of the knockout mouse.
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Investigation into the antioxidant role of arginine in the treatment and the protection for intralipid-induced non-alcoholic steatohepatitis.
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Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver.
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Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development.
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Involvement of the arachidonic acid cytochrome P450 epoxygenase pathway in the proliferation and invasion of human multiple myeloma cells.
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Irbesartan mitigates acute liver injury, oxidative stress, and apoptosis induced by acetaminophen in mice.
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Irinotecan pharmacokinetic and pharmacogenomic alterations induced by methylselenocysteine in human head and neck xenograft tumors.
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Is an alternative drug delivery system needed for docetaxel? The role of controlling epimerization in formulations and beyond.
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Is aryl hydrocarbon hydroxylase activity a new prognostic indicator for breast cancer?
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Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes.
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Joint effects of inflammation and androgen metabolism on prostate cancer severity.
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Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1.
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Ki-ras mutations are an early event and correlate with tumor stage in transplacentally-induced murine lung tumors.
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Kidney injury and alterations of inflammatory cytokine expressions in mice following long-term exposure to cerium chloride.
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Labeled 3-aryl-4-indolylmaleimide derivatives and their potential as angiogenic PET biomarkers.
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Lack of any association between functionally significant CYP2D6 polymorphisms and clinical outcomes in early breast cancer patients receiving adjuvant tamoxifen treatment.
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Lack of association among polymorphic xenobiotic-metabolizing enzyme genotypes and the occurrence and progression of oral carcinoma in a Brazilian population.
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Lack of association between CYP2A5 induction and apoptosis in mouse primary hepatocytes.
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Lack of association between polymorphisms in the CYP1A2 gene and risk of cancer: evidence from meta-analyses.
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Lack of Association of CYP1A1 Polymorphism with Prostate Cancer Susceptibility of Tunisian Men.
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Lack of association of CYP1A1-MspI SNP and GSTM1 null genotypes with cancer in a Brazilian family with unusually high cancer incidence.
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Lack of associations among cancer and albumin adducts, ras p21 oncoprotein levels, and CYP1A1, CYP2D6, NAT1, and NAT2 in a nested case-control study of lung cancer within the physicians' health study.
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Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver.
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Lessons for pharmacogenomics studies: association study between CYP2D6 genotype and tamoxifen response.
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Let-7b inhibits human cancer phenotype by targeting cytochrome P450 epoxygenase 2J2.
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Liposome mediated-CYP1A1 gene silencing nanomedicine prepared using lipid film-coated proliposomes as a potential treatment strategy of lung cancer.
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Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action.
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Lobatin B inhibits NPM/ALK and NF-?B attenuating anaplastic-large-cell-lymphomagenesis and lymphendothelial tumour intravasation.
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Localization and expression of adrenocorticotropic hormone receptor mRNA in normal and neoplastic human adrenal cortex.
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Localization of Cytochrome P4502E1 Enzyme in Normal and Cancerous Gastric Mucosa and Association with Its Genetic Polymorphism in Unoperated and Remnant Stomach.
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Localized aberrant expression of cytochrome P450 aromatase in primary and metastatic malignant tumors of human liver.
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Long-chain carboxychromanols are the major metabolites of tocopherols and tocotrienols in A549 lung epithelial cells but not HepG2 cells.
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Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells.
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Long-term exposure of 4-hydroxyestradiol induces the cancer cell characteristics via upregulating CYP1B1 in MCF-10A cells.
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Loss of alanine-glyoxylate and serine-pyruvate aminotransferase expression accelerated the progression of hepatocellular carcinoma and predicted poor prognosis.
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Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.
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Loss of miR-200c up-regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma.
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Loss of tumor-promoting activity of unleaded gasoline in N-nitrosodiethylamine-initiated ovariectomized B6C3F1 mouse liver.
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Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: possible mechanisms.
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Low hepatic glutathione S-transferase and increased hepatic DNA adduction contribute to increased tumorigenicity of aflatoxin B1 in newborn and partially hepatectomized mice.
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Low synthesis of retinoic acid due to impaired cytochrome P450 1a1 expression in mouse xeroderma pigmentosum fibroblasts.
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Lower levels of urinary 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) in humans with higher CYP1A2 activity.
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Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway.
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Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation.
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Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.
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Maltol Improves APAP-Induced Hepatotoxicity by Inhibiting Oxidative Stress and Inflammation Response via NF-?B and PI3K/Akt Signal Pathways.
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Mapping in pig of genes involved in sexual differentiation: AMH, WT1, FTZF1, SOX2, SOX9, AHC, and placental and embryonic CYP19.
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Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes.
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Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant Therapy.
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Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice.
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Mechanism Comparison of Gemcitabine and Dasatinib-Resistant Pancreatic Cancer by Integrating mRNA and miRNA Expression Profiles.
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Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.
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Mechanisms of alcohol-associated cancers: introduction and summary of the symposium.
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Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.
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Mechanisms of down-regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells.
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Membrane topology and search for potential redox partners of colon cancer-specific cytochrome P450 2W1.
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Meta-analyses of the effect of cytochrome P450 2E1 gene polymorphism on the risk of head and neck cancer.
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Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review.
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Meta-analysis of association studies of CYP1A1 genetic polymorphisms with digestive tract cancer susceptibility in Chinese.
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Metabolic activation of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and DNA adduct formation depends on p53: Studies in Trp53(+/+),Trp53(+/-) and Trp53(-/-) mice.
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Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1.
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Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1.
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Metabolic behavior prediction of pazopanib by cytochrome P450 (CYP) 3A4 by molecular docking.
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Metabolic characteristics and enflurane defluorination of cytochrome P450-dependent monooxygenases in human hepatocellular carcinoma.
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Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans.
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Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells.
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Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human CYP1B1 genetic variants.
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Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human placental microsomes.
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Metabolism of benzo(a)pyrene in animals with high aryl hydrocarbon hydroxylase levels and high rates of spontaneous cancer.
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Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1.
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Metabolism of the soyabean isoflavone daidzein by CYP1A2 and the extra-hepatic CYPs 1A1 and 1B1 affects biological activity.
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Metal-mediated DNA damage induced by curcumin in the presence of human cytochrome P450 isozymes.
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Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.
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Methylation patterns of genes coding for drug-metabolizing enzymes in tamoxifen-resistant breast cancer tissues.
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MGMT- and P450 3A-inhibitors do not sensitize glioblastoma cell cultures against nitrosoureas.
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Micro1278 Leads to Tumor Growth Arrest, Enhanced Sensitivity to Oxaliplatin and Vitamin D and Inhibits Metastasis via KIF5B, CYP24A1, and BTG2, Respectively.
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Microencapsulated, CYP2B1-transfected cells activating ifosfamide at the site of the tumor: the magic bullets of the 21st century.
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MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer (NSCLC) through down-regulation of CYP1B1.
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Microsomal metabolites of the aryl hydrocarbon hydroxylase and tumour inhibitor 7,8-benzoflavone.
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Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors.
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Mining the NCI screening database: explorations of agents involved in cell cycle regulation.
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Minor contribution of cytochrome P450 3A activity on fentanyl exposure in palliative care cancer patients.
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miR-204 functions as a tumor suppressor gene, at least partly by suppressing CYP27A1 in glioblastoma.
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miR-30a promoter variation contributes to the increased risk of colorectal cancer in an Iranian population.
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Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells.
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Mode of action analysis for pesticide-induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk.
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Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation.
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Modeling receptor-mediated processes with dioxin: implications for pharmacokinetics and risk assessment.
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Modification of DENA-induced hepatocarcinogenesis by CCl4 cirrhosis. Comparison of the marker enzyme patterns.
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Modification of paclitaxel metabolism in a cancer patient by induction of cytochrome P450 3A4.
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Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: a key factor in controlling hypoxia-selective drug release.
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Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors.
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Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options.
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Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line.
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Modulation of hepatic cytochrome P450s by citrobacter rodentium infection in interleukin-6- and interferon-{gamma}-null mice.
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Modulation of human cytochrome P450 1B1 expression by 2,4,3',5'-tetramethoxystilbene.
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Modulation of xenobiotic-metabolizing enzymes by ethanolic neem leaf extract during hamster buccal pouch carcinogenesis.
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Molecular aspects and chemoprevention of dimethylaminoazobenzene-induced hepatocarcinogenesis: A review.
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Molecular basis of severe gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma.
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Molecular cloning and expression of novel alternatively spliced cytochrome P450 2E1 mRNAs in humans.
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Molecular dynamics simulation studies for DNA sequence recognition by reactive metabolites of anticancer compounds.
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Molecular genetic analysis of the cytochrome P450-debrisoquine hydroxylase locus and association with cancer susceptibility.
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Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment.
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Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine.
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Molecular mechanism of kidney injury of mice caused by exposure to titanium dioxide nanoparticles.
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Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implications for human lung cancer.
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Molecular pathways involved in the improvement of non-alcoholic fatty liver disease.
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Monitoring Cyp2b10 mRNA expression at cessation of 2-year carcinogenesis bioassay in mouse liver provides evidence for a carcinogenic mechanism devoid of human relevance: The dalcetrapib experience.
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Mono-(2-ethylhexyl) phthalate induces NR4A subfamily and GIOT-1 gene expression, and suppresses CYP19 expression in human granulosa-like tumor cell line KGN.
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Monodictyochromes A and B, Dimeric Xanthone Derivatives from the Marine Algicolous Fungus Monodictys putredinis.
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Mouse lung tumors exhibit specific Ki-ras mutations following transplacental exposure to 3-methylcholanthrene.
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MspI and Ile462Val polymorphisms in CYP1A1 and overall cancer risk: a meta-analysis.
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Multi-omics characterization and validation of MSI-related molecular features across multiple malignancies.
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Multifunctionalized biocatalytic P22 nanoreactor for combinatory treatment of ER+ breast cancer.
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Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies.
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Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual.
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Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: main effect of indole-3-carbinol.
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Multiplex PCR with confronting two-pair primers for CYP1A1 Ile462Val, GSTM1, GSTT1, and NQO1 C609T.
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Mutagenicity of cytochrome P450 2E1 substrates in the Ames test with the metabolic competent S. typhimurium strain YG7108pin3ERb5.
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Mutation and protein expression analysis of CYP1A1 gene-a study on female breast cancer cases from India.
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N,N',N''-triethylenethiophosphoramide (thio-TEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents.
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N,N-diethyl-2-[4-(phenylmethyl) phenoxy] ethanamine (DPPE; tesmilifene), a chemopotentiating agent with hormetic effects on DNA synthesis in vitro, may improve survival in patients with metastatic breast cancer.
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n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
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N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis.
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N-Hydroxylation of 4-Aminobiphenyl by CYP2E1 Produces Oxidative Stress in a Mouse Model of Chemically Induced Liver Cancer.
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Natural anticarcinogens, carcinogens, and changing patterns in cancer: some speculation.
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Natural Cancer Therapy and Prevention Targeted on Cancer Cells and Cancer Stem Cells Based on the Cytochrome P45O Enzyme CYP1B1: A Commentary.
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Naturally occurring coumarins inhibit human cytochromes P450 and block benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene DNA adduct formation in MCF-7 cells.
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Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism.
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Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase.
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New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments.
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New CYP2A6 gene deletion and conversion variants in a population of Black African descent.
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New cytochrome P450 isoforms as cancer biomarkers and targets for chemopreventive and chemotherapeutic agents.
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New ifosfamide analogs designed for lower associated neurotoxicity and nephrotoxicity with modified alkylating kinetics leading to enhanced in vitro anticancer activity.
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New opportunities in cancer risk evaluation using PCR-based DNA analysis for CYP2D6.
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New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol.
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NF-?B and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice.
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Nitric oxide-independent suppression of P450 2C11 expression by interleukin-1beta and endotoxin in primary rat hepatocytes.
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No association between polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the risk of gastric adenocarcinoma in the European prospective investigation into cancer and nutrition.
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No effect of thromboxane A2 on the attachment of tumor cell lines MDA MB 231, DU145, and U937 to the basement membrane in an in-vitro model.
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Nonparametric expectation maximisation (NPEM) population pharmacokinetic analysis of caffeine disposition from sparse data in adult caucasians: systemic caffeine clearance as a biomarker for cytochrome P450 1A2 activity.
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Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.
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Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells.
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Novel single nucleotide polymorphisms (SNPs) of CYP2W1 gene in Chinese Uygur and Han populations.
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Novel Synthetic Analogues of 19(S/R)-Hydroxyeicosatetraenoic Acid Exhibit Noncompetitive Inhibitory Effect on the Activity of Cytochrome P450 1A1 and 1B1.
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Nutrition and the prevention and treatment of cancer: association of cytochrome P450 CYP1B1 with the role of fruit and fruit extracts.
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Oestrogen-receptors (ER) are likely to be promiscuous: wider role for oestrogens and mimics.
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Of humans and hamsters: A comparative evaluation of carcinogen activation, DNA damage, cell proliferation, apoptosis, invasion, and angiogenesis in oral cancer patients and hamster buccal pouch carcinomas.
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Oltipraz inhibits 3-methylcholanthrene induction of CYP1A1 by CCAAT/enhancer-binding protein activation.
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Omega-6-derived oxylipin changes in serum of patients with hepatitis B virus-related liver diseases.
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On the mechanism of hepatocarcinogenesis of benzodiazepines: evidence that diazepam and oxazepam are CYP2B inducers in rats, and both CYP2B and CYP4A inducers in mice.
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On the relationship between VDR, ROR? and ROR? receptors expression and HIF1-? levels in human melanomas.
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Oncogenic and cell survival properties of the retinoic acid metabolizing enzyme, CYP26A1.
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Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus.
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Oral and oropharyngeal cancer, aryl hydrocarbon hydroxylase inducibility and smoking. A follow-up study.
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Oral anticoagulation with warfarin is significantly influenced by steroids and CYP2C9 polymorphisms in children with cancer.
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Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct.
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Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm.
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Oral paclitaxel and concurrent cyclosporin A: targeting clinically relevant systemic exposure to paclitaxel.
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Oral sodium phenylbutyrate in patients with recurrent malignant gliomas: a dose escalation and pharmacologic study.
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Origin of an ovarian steroid cell tumor causing isosexual pseudoprecocious puberty demonstrated by the expression of adrenal steroidogenic enzymes and adrenocorticotropin receptor.
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Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and SF-1 expressions.
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Ovarian Tumors With Functioning Stroma: A Clinicopathologic Study With Special Reference to Serum Estrogen Level, Stromal Morphology, and Aromatase Expression.
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Overcoming Taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin.
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Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis.
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Overexpression of cytochrome P450 1B1 in advanced non-small cell lung cancer: a potential therapeutic target.
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Overexpression of the cytochrome p450 activator hpr6 (heme-1 domain protein/human progesterone receptor) in tumors.
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Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.
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Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor.
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Oxidations of 17beta-estradiol and estrone and their interconversions catalyzed by liver, mammary gland and mammary tumor after acute and chronic treatment of rats with indole-3-carbinol or beta-naphthoflavone.
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P-glycoprotein associated with diabetes mellitus and survival of patients with pancreatic cancer: 8-year follow-up.
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P450 CYP1B1 mediated fluorescent tumor markers: a potentially useful approach for photodynamic therapy, diagnosis and establishing surgical margins.
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P450 genes: evolution, regulation, and relationship to human cancer and pharmacogenetics.
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P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer.
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P450 induction alters paclitaxel pharmacokinetics and tissue distribution with multiple dosing.
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p53 gene mutations, and CYP1A1 and GSTM1 genotypes in pulmonary squamous cell carcinomas.
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p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated patients with non-small cell lung cancer.
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p53, but not p16 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use.
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Pan-fried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans.
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Participation of CYP2C8 in retinoic acid 4-hydroxylation in human hepatic microsomes.
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Pathway Crosstalk Analysis of Microarray Gene Expression Profile in Human Hepatocellular Carcinoma.
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Pathway-dependent inhibition of paclitaxel hydroxylation by kinase inhibitors and assessment of drug-drug interaction potentials.
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Patterns of expression of cytochrome P450 genes in progression of hepatitis C virus-associated hepatocellular carcinoma.
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Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T.
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Peroxidase-dependent bioactivation and oxidation of DNA and protein in benzo[a]pyrene-initiated micronucleus formation.
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Peroxisome proliferator-induced hepatocarcinogenesis: levels of activating and detoxifying enzymes in hepatocellular carcinomas induced by ciprofibrate.
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Perspective of structural flexibility on selective inhibition towards CYP1B1 over CYP1A1 by ?-naphthoflavone analogs.
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PGRMC2, a yet uncharacterized protein with potential as tumor suppressor, migration inhibitor, and regulator of cytochrome P450 enzyme activity.
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Pharmacogenetic variants and response to neoadjuvant single-agent doxorubicin or docetaxel: a study in locally advanced breast cancer patients participating in the NCT00123929 phase 2 randomized trial.
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Pharmacogenetics and regulation of human cytochrome P450 1B1: implications in hormone-mediated tumor metabolism and a novel target for therapeutic intervention.
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Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes.
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Pharmacogenomics to Predict Tumor Therapy Response: A Focus on ATP-Binding Cassette Transporters and Cytochromes P450.
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Pharmacokinetic (PK) drug interaction studies of cabozantinib: Effect of CYP3A inducer rifampin and inhibitor ketoconazole on cabozantinib plasma PK and effect of cabozantinib on CYP2C8 probe substrate rosiglitazone plasma PK.
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Pharmacokinetic drug interactions of gefitinib with rifampicin, itraconazole and metoprolol.
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Pharmacokinetic studies with recombinant cytokines. Scientific issues and practical considerations.
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Pharmacokinetics of 5-fluorouracil in mutant Nagase analbuminemic rats: faster metabolism of 5-fluorouracil via CYP1A.
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Pharmacokinetics of S-1 and CYP2A6 genotype in Japanese patients with advanced cancer.
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Pharmacologic and phenotypic study of docetaxel in patients with ovarian or primary peritoneal cancer.
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Pharmacological Targets and the Biological Mechanisms of Formononetin for Alzheimer's Disease: A Network Analysis.
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Phase I and pharmacological study of the pulmonary cytotoxin 4-ipomeanol on a single dose schedule in lung cancer patients: hepatotoxicity is dose limiting in humans.
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Phase I study of cabazitaxel plus cisplatin in patients with advanced solid tumors: study to evaluate the impact of cytochrome P450 3A inhibitors (aprepitant, ketoconazole) or inducers (rifampin) on the pharmacokinetics of cabazitaxel.
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Phase I study of MetXia-P450 gene therapy and oral cyclophosphamide for patients with advanced breast cancer or melanoma.
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Phase I/II clinical trial of encapsulated, cytochrome P450 expressing cells as local activators of cyclophosphamide to treat spontaneous canine tumours.
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Phase II study of 4-ipomeanol, a naturally occurring alkylating furan, in patients with advanced hepatocellular carcinoma.
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Phase II study of S-1 combined with oxaliplatin as therapy for patients with metastatic biliary tract cancer: influence of the CYP2A6 polymorphism on pharmacokinetics and clinical activity.
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Phenobarbital increases DNA adduct and metabolites formed by ochratoxin A: role of CYP 2C9 and microsomal glutathione-S-transferase.
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Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion.
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Pheochromocytoma and sub-clinical Cushing's syndrome during pregnancy: diagnosis, medical pre-treatment and cure by laparoscopic unilateral adrenalectomy.
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Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo.
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Phytoestrogen exposure correlation with plasma estradiol in postmenopausal women in European Prospective Investigation of Cancer and Nutrition-Norfolk may involve diet-gene interactions.
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Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1.
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Phytotherapeutic approach: a new hope for polycyclic aromatic hydrocarbons induced cellular disorders, autophagic and apoptotic cell death.
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Pleiotropic Functions of Cytochrome P450 Monooxygenase-Derived Eicosanoids in Cancer.
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Pleomorphic (giant and/or spindle cell) carcinoma of lung shows a high percentage of variant CYP1A12.
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Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population.
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Polymorphic variation of Cyp1A1 is associated with the risk of gastric cardia cancer: a prospective case-cohort study of cytochrome P-450 1A1 and GST enzymes.
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Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma.
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Polymorphism in CYP1A1 and CYP2D6 genes: possible association with susceptibility to lung cancer.
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Polymorphism in CYP24A1 Is Associated with Lung Cancer Risk: A Case-Control Study in Chinese Female Nonsmokers.
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Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers.
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Polymorphism of metabolizing genes and lung cancer histology: prevalence of CYP2E1 in adenocarcinoma.
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Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients.
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Polymorphisms in drug-metabolizing enzymes and risk to head and neck cancer: evidence for gene-gene and gene-environment interaction.
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Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol.
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Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men.
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Polymorphisms in the CYP1B1 gene are associated with increased risk of prostate cancer.
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Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk.
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Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses.
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Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese.
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Polymorphisms of cytochrome P450 1A1, glutathione S-transferases M1 and T1 in a Turkish population.
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Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer.
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Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study.
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Polymorphisms of genes encoding drug transporters or cytochrome P450 enzymes and association with clinical response in cancer patients: a systematic review.
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Polymorphisms of the CYP1A1 and CYP2E1 genes in head and neck squamous cell carcinoma risk.
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Polymorphisms of the CYP1A1 and GSTM1 genes in relation to individual susceptibility to lung carcinoma in Chinese population.
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Polymorphisms of the CYP1A1, CYP2E1 and XRCC1 genes and cancer risk in a Southern Italian population: a case-control study.
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Polymorphisms of tumor necrosis factor-alpha, interleukin-10, cytochrome P450 3A5 and ABCB1 in Chinese liver transplant patients treated with immunosuppressant tacrolimus.
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Polymorphisms related to estrogen and xenobiotic metabolism in healthy Turkish women.
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Poor metabolizer genotype status of CYP2C19 is a risk factor for developing gastric cancer in Japanese patients with Helicobacter pylori infection.
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Poor Metabolizers at the Cytochrome P450 2C19 Loci Is at Increased Risk of Developing Cancer in Asian Populations.
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Population pharmacokinetics and pharmacogenetics of vincristine in paediatric patients treated for solid tumour diseases.
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Population pharmacokinetics and pharmacokinetics/pharmacodynamics of bendamustine in pediatric patients with relapsed/refractory acute leukemia.
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Population Pharmacokinetics of Phenytoin Based on NONMEN in Patients with Intracranial Tumor during the First Week of Post-craniotomy.
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Possible role of riboflavin deficiency in epithelial neoplasia. 3. Induction of microsomal aryl hydrocarbon hydroxylase.
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Post-initiation treatment of rats with indole-3-carbinol or beta-naphthoflavone does not suppress 7, 12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis.
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Potent antitumor and antineoplastic efficacy of baicalein on benzo(a)pyrene-induced experimental pulmonary tumorigenesis.
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Potent inhibition of human cytochrome P450 1 enzymes by dimethoxyphenylvinyl thiophene.
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Potent inhibitory effects of suicide inhibitors of P450 isozymes on 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene initiated skin tumors.
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Potential contribution of cytochrome P450 2B6 to hepatic 4-hydroxycyclophosphamide formation in vitro and in vivo.
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Potential differences in breast cancer risk factors based on CYP1A1 MspI and African-American-specific genotypes.
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Potential for estrogen synthesis and action in human normal and neoplastic thyroid tissues.
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Potential pathogenetic link between angiomyofibroblastoma and superficial myofibroblastoma in the female lower genital tract based on a novel MTG1-CYP2E1 fusion.
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Potential role of gut microbiota, the proto-oncogene PIKE (Agap2) and cytochrome P450 CYP2W1 in promotion of liver cancer by alcoholic and nonalcoholic fatty liver disease and protection by dietary soy protein.
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Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene.
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Preclinical studies of amixicile, a systemic therapeutic developed for treatment of Clostridium difficile infections that also shows efficacy against Helicobacter pylori.
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Prediction of paclitaxel resistance in breast cancer: is CYP1B1*3 a new factor of influence?
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Prediction of the drug-drug interaction potential of the ?1-acid glycoprotein bound, CYP3A4/CYP2C9 metabolized oncology drug, erdafitinib.
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Predominance of a cell population less sensitive to carcinogenesis in neoplastic cells of 3-methylcholanthrene-induced tumors in mouse aggregation chimeras.
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Preferential inducibility of CYP1A1 and CYP1A2 by TCDD: differential regulation in primary human hepatocytes versus transformed human cells.
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Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia.
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Prenylflavonoids from hops inhibit the metabolic activation of the carcinogenic heterocyclic amine 2-amino-3-methylimidazo[4, 5-f]quinoline, mediated by cDNA-expressed human CYP1A2.
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Pretranslational down-regulation of cytochromes P450 2C11 and 3A2 in male rat liver by tumor necrosis factor alpha.
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Pretreatment with black tea polyphenols modulates xenobiotic-metabolizing enzymes in an experimental oral carcinogenesis model.
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Prevalence of five pharmacologically most important CYP2C9 and CYP2C19 allelic variants in the population from the Republic of Srpska in Bosnia and Herzegovina.
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Preventive medical services not covered by public health insurance at Daiko Medical Center in Japan, 2004-2011.
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Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells.
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Primary gene-engineered neural stem/progenitor cells demonstrate tumor-selective migration and antitumor effects in glioma.
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Principal xenobiotic-metabolizing enzyme systems in human head and neck squamous cell carcinoma.
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Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds.
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Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking.
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Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene.
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Prodrugs: effective solutions for solubility, permeability and targeting challenges.
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Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.
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Progesterone potentiates the growth inhibitory effects of calcitriol in endometrial cancer via suppression of CYP24A1.
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Progesterone receptor inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanisms.
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Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes.
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Progestins inhibit calcitriol-induced CYP24A1 and synergistically inhibit ovarian cancer cell viability: An opportunity for chemoprevention.
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Prognostic significance of germ line polymorphisms of the CYP1A1 and glutathione S-transferase genes in patients with non-small cell lung cancer.
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Prognostic value of using glucosylceramide synthase and cytochrome P450 family 1 subfamily A1 expression levels for patients with triple-negative breast cancer following neoadjuvant chemotherapy.
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Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking.
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Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient mice.
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Promoter Hypermethylation Profiling Identifies Subtypes of Head and Neck Cancer with Distinct Viral, Environmental, Genetic and Survival Characteristics.
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Promotion of mouse lung tumors by bioaccumulated polychlorinated aromatic hydrocarbons.
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Promotion of preneoplastic lesions and induction of CYP2B by unleaded gasoline vapor in female B6C3F1 mouse liver.
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Properties of aryl hydrocarbon hydroxylase in microsomes of Morris hepatoma 5123D and the host liver.
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Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways.
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Proteasomal degradation of human CYP1B1: effect of the Asn453Ser polymorphism on the post-translational regulation of CYP1B1 expression.
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Protective effect of a polysaccharide from Anoectochilus roxburghii against carbon tetrachloride-induced acute liver injury in mice.
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Protective effects of combined Losartan and Nilotinib on carbon tetrachloride (CCl4)-induced liver fibrosis in rats.
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Protective Effects of Silymarin, Alone or in Combination with Chlorogenic Acid and/or Melatonin, Against Carbon Tetrachloride-induced Hepatotoxicity.
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Protein kinase A-dependent synergism between GATA factors and the nuclear receptor, liver receptor homolog-1, regulates human aromatase (CYP19) PII promoter activity in breast cancer cells.
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Pulmotoxicological effects caused by long-term titanium dioxide nanoparticles exposure in mice.
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Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors.
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Quantitation of P450 aromatase immunoreactivity in human ovary during the menstrual cycle: relationship between the enzyme activity and immunointensity.
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Quantitative assessment of the influence of cytochrome P450 2C19 gene polymorphisms and digestive tract cancer risk.
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Quantitative PCR assay for cytochromes P450 2B and 3A induction in rat precision-cut liver slices: correlation study with induction in vivo.
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Quinazolinone derivative BNUA-3 ameliorated [NDEA+2-AAF]-induced liver carcinogenesis in SD rats by modulating AhR-CYP1B1-Nrf2-Keap1 pathway.
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Rabbit cytochrome P450 4B1: A novel prodrug activating gene for pharmacogene therapy of hepatocellular carcinoma.
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Radiosynthesis of [(124)I]Iodometomidate and Biological Evaluation Using Small-Animal PET.
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Rare naturally occurring immune responses to three epitopes from the widely expressed tumour antigens hTERT and CYP1B1 in multiple myeloma patients.
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Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism.
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Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.
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Re: London,S.J. et al. (1997) Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County. Carcinogenesis, 18, 1203-1214.
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Re: S. J. London et al., Lung cancer risk in African-Americans in relation to a race-specific CYP1A1 polymorphism. Cancer Res., 55: 6035-6037, 1995.
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Real-time reverse transcription PCR assay of CYP19 expression: application to a well-defined series of post-menopausal breast carcinomas.
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Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen.
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Recombinant antibody piezoimmunosensors for the detection of cytochrome P450 1B1.
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Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1.
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Recombinant tumor necrosis factor depresses cytochrome P450-dependent microsomal drug metabolism in mice.
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Recurrent gene amplifications in human type I endometrial adenocarcinoma detected by fluorescence in situ hybridization.
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Reduction in 7,12-dimethylbenz[a]anthracene-induced hepatic cytochrome-P450 1A1 expression following soy consumption in female rats is mediated by degradation of the aryl hydrocarbon receptor.
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Refinement of an ovarian cancer tumour suppressor gene locus on chromosome arm 22q and mutation analysis of CYP2D6, SREBP2 and NAGA.
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Regional mapping of short tandem repeats on human chromosome 10: cytochrome P450 gene CYP2E, D10S196, D10S220, and D10S225.
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Regulation of aromatase gene expression in purified germ cells of adult male rats: effects of transforming growth factor beta, tumor necrosis factor alpha, and cyclic adenosine 3',5'-monosphosphate.
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Regulation of CYP19 gene expression in primary human osteoblasts: effects of vitamin D and other treatments.
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Regulation of Cytochrome P450 1B1 Expression by Luteinizing Hormone in Mouse MA-10 and Rat R2C Leydig Cells: Role of Protein Kinase A.
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Regulation of cytochrome P450 gene expression in human colon and breast tumour xenografts.
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Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.
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Relationship between aromatase activity and steroid receptor levels in ovarian tumors from postmenopausal women.
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Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in colorectal cancer.
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Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in Xinjiang, China.
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Relationship between the debrisoquine hydroxylase polymorphism and cancer susceptibility.
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Relationship between the plasma fentanyl and serum 4?-hydroxycholesterol based on CYP3A5 genotype and gender in patients with cancer pain.
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Relative Contributions of CYP1A2 and CYP2E1 to the Bioactivation and Clearance of 4-Aminobiphenyl in Adult Mice.
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Relative Expression of Vitamin D Hydroxylases, CYP27B1 and CYP24A1, and of Cyclooxygenase-2 and Heterogeneity of Human Colorectal Cancer in Relation to Age, Gender, Tumor Location, and Malignancy: Results from Factor and Cluster Analysis.
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Relevance of glutathione S-transferase M1 and cytochrome P450 1A1 genetic polymorphisms to the development of head and neck cancers.
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Renal Transcriptomics Reveals the Carcinogenic Mechanism of Ethyl Carbamate in Musalais.
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Repeated immunization with plasmid DNA formulated in poly(lactide-co-glycolide) microparticles is well tolerated and stimulates durable T cell responses to the tumor-associated antigen cytochrome P450 1B1.
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Resveratrol enhances the sensitivity of cholangiocarcinoma to chemotherapeutic agents.
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Rethinking tamoxifen in the management of melanoma: New answers for an old question.
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Retinoic acid antagonizes basal as well as coal tar and glucocorticoid-induced cytochrome P4501A1 expression in human skin.
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Retraction: Polymorphisms of the CYP1B1 Gene as Risk Factors for Human Renal Cell Cancer.
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Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy.
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Review article: the potential mechanisms of action of rifaximin in the management of inflammatory bowel diseases.
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Review of studies on metabolic genes and cancer in populations of African descent.
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Right and left-sided colon cancers - specificity of molecular mechanisms in tumorigenesis and progression.
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Risk genes in head and neck cancer: a systematic review and meta-analysis of last 5 years.
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Risk of testicular germ cell cancer in relation to variation in maternal and offspring cytochrome p450 genes involved in catechol estrogen metabolism.
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RNA-sequencing studies identify genes differentially regulated during inflammation-driven lung tumorigenesis and targeted by chemopreventive agents.
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Role and importance of polymorphisms with respect to DNA methylation for the expression of CYP2E1 enzyme.
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Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract.
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Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11alpha in prostate cancer risk and aggressiveness.
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Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells.
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Role of CYP1A2 1F polymorphism in cancer risk: evidence from a meta-analysis of 46 case-control studies.
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Role of CYP4F2 as a novel biomarker regulating malignant phenotypes of liver cancer cells via the Nrf2 signaling axis.
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Role of cytochrome P450 1a1 and 1b1 in the metabolic activation of 7,12-dimethylbenz[a]anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation.
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Role of cytochrome P450 activity in the fate of anticancer agents and in drug resistance: focus on tamoxifen, paclitaxel and imatinib metabolism.
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Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity.
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Role of cytokines in the lipopolysaccharide-evoked depression of cytochrome P450 in the brain and liver.
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Role of endoplasmic reticulum stress in lipopolysaccharide-inhibited mouse granulosa cell estradiol production.
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Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium.
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Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation.
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Role of host susceptibility to toxicity and cancer caused by pesticides: cytochromes P450.
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Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP.
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Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma.
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Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers.
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Role of nitric oxide and nuclear factor-kappaB in the CYP2E1 potentiation of tumor necrosis factor alpha hepatotoxicity in mice.
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Role of nitric oxide in downregulation of cytochrome P450 1a1 and NADPH: Quinone oxidoreductase 1 by tumor necrosis factor-alpha and lipopolysaccharide.
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Role of phenobarbital-inducible cytochrome P450s as a source of active oxygen species in DNA-oxidation.
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Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytes.
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Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
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Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction.
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Role of the maternal environment in determining susceptibility to transplacentally induced chemical carcinogenesis in mouse fetuses.
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Role of the progesterone receptor (PR) in the regulation of inflammatory response pathways and aromatase in the breast.
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Role of tumor necrosis factor-alpha in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin.
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Role of xenobiotic metabolism in cancer: involvement of transcriptional and miRNA regulation of P450s.
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Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms.
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RRM1, TUBB3, TOP2A, CYP19A1, CYP2D6: Difference between mRNA and protein expression in predicting prognosis of breast cancer patients.
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RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma.
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S-1 plus irinotecan and oxaliplatin for the first-line treatment of patients with metastatic colorectal cancer: a prospective phase II study and pharmacogenetic analysis.
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S-Warfarin Limited Sampling Models to Estimate Area Under the Concentration Versus Time Curve for Cytochrome P450 2C9 Baseline Activity and Following Induction.
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S2R(Pgrmc1): the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling.
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Salutary clinical response of prostate cancer to antiandrogen withdrawal: assessment of flutamide in an in vitro paradigm predictive of tumor growth enhancement.
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Samarium enriches antitumor activity of ZnO nanoparticles via downregulation of CXCR4 receptor and cytochrome P450.
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Selection of cytochrome p450 genes for use in prodrug activation-based cancer gene therapy.
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Selective Antitumor Effect of Shikonin Derived DMAKO-20 on Melanoma through CYP1B1.
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Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions.
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Selective poisoning of Ctnnb1-mutated hepatoma cells in mouse liver tumors by a single application of acetaminophen.
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Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen.
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Self-packed core shell nano liquid chromatography columns and silica-based monolithic trap columns for targeted proteomics.
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Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.
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Sequence Polymorphism in Xenobiotic Metabolising Genes in Iraqi Colorectal Cancer Patients.
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Serous borderline ovarian tumor with functioning stroma in a postmenopausal woman: immunohistochemical analysis of steroidogenic pathway.
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Serum perfluorooctanoic acid and hepatic enzymes, lipoproteins, and cholesterol: a study of occupationally exposed men.
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Serum, plasma and paraffin-embedded tissues as sources of DNA for studying cancer susceptibility genes.
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Sex hormone modulation of both induction and inhibition of CYP1A by genistein in HepG2/C3A cells.
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Sex- and strain-specific induction of renal tumors by ochratoxin A in rats correlates with DNA adduction.
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Sheep gene mapping: assignment of ALDOB, CYP19, WT and SOX2 by somatic cell hybrid analysis.
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Sheep lung cytochrome P4501A1 (CYP1A1): cDNA cloning and transcriptional regulation by oxygen tension.
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Side effects associated with ultrarapid cytochrome P450 2D6 genotype among women with early stage breast cancer treated with tamoxifen.
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Significance of steroidogenic enzymes in the pathogenesis of hyperfunctioning and non-hyperfunctioning adrenal tumor.
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Significant association between CYP1A1 T3801C polymorphism and cervical neoplasia risk: a systematic review and meta-analysis.
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Significant genotype difference in the CYP2E1 PstI polymorphism of indigenous groups in Sabah, Malaysia with Asian and non-Asian populations.
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Significant transcriptional down-regulation of the human MDR1 gene by beta-naphthoflavone: a proposed hypothesis linking potent CYP gene induction to MDR1 inhibition.
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Simple and accurate visual detection of single nucleotide polymorphism based on colloidal gold nucleic acid strip biosensor and primer-specific PCR.
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Single or Multiple Access Channels to the CYP450s Active Site? An Answer from Free Energy Simulations of the Human Aromatase Enzyme.
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Single-cell analyses of transcriptional heterogeneity in squamous cell carcinoma of urinary bladder.
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Skin response to a carcinogen involves the xenobiotic receptor pregnane X receptor.
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Small agarose microcapsules with cell-enclosing hollow core for cell therapy: Transplantation of ifosfamide-activating cells to the mice with pre-established subcutaneous tumor.
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Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer.
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Smoking-associated bulky DNA adducts in bronchial tissue related to CYP1A1 MspI and GSTM1 genotypes in lung patients.
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SNP analysis combined with protein structure prediction defines structure-functional relationships in cancer related cytochrome P450 estrogen metabolism.
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Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation.
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Spectral Modification and Catalytic Inhibition of Human Cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by Four Chemopreventive Organoselenium Compounds.
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Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity.
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Steatosis in chronic hepatitis C: association with increased messenger RNA expression of collagen I, tumor necrosis factor-alpha and cytochrome P450 2E1.
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Steroid 21-hydroxylase mutations and 21-hydroxylase messenger ribonucleic acid expression in human adrenocortical tumors.
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Steroid hormone synthesis by the ovarian stroma surrounding epithelial ovarian tumors: a potential mechanism in ovarian tumorigenesis.
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Steroid hormone-dependent overexpression of cytochromes P450 2A in liver tumors of TGF alpha transgenic male mice.
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Steroid hormones modulate expression of cytochrome P450 enzymes in male hamster reproductive tract and leiomyosarcomas.
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Steroid metabolism gene polymorphisms and their implications on breast and ovarian cancer prognosis.
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Stimulation of Diethylnitrosamine Metabolism Reduces Its General Toxic and Hepatocarcinogenic Effects.
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Strain-related differences in mouse lung gene expression over a two-year period of inhalation exposure to styrene: Relevance to human risk assessment.
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Structural diversity of anti-pancreatic cancer capsimycins identified in mangrove-derived Streptomyces xiamenensis 318 and post-modification via a novel cytochrome P450 monooxygenase.
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Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands.
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Study of the frequencies of CYP1A1 gene polymorphisms and glutathione S-transferase mu1 gene in primary breast cancers: an update with an additional 114 cases.
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Subsieve-size agarose capsules enclosing ifosfamide-activating cells: a strategy toward chemotherapeutic targeting to tumors.
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SUMOylation of AhR modulates its activity and stability through inhibiting its ubiquitination.
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Suppression of CYP2C9 by MicroRNA hsa-miR-128-3p in Human Liver Cells and Association with Hepatocellular Carcinoma.
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Suppression of hepatic drug metabolism by the interferon inducer, polyriboinosinic acid:polyribocitidylic acid.
Neoplasms
Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by bergamottin via the inhibition of protein kinase Cdelta/p38 mitogen-activated protein kinase and JNK/nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression.
Neoplasms
Suppressive effects of caraway (Carum carvi) extracts on 2, 3, 7, 8-tetrachloro-dibenzo-p-dioxin-dependent gene expression of cytochrome P450 1A1 in the rat H4IIE cells.
Neoplasms
Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6.
Neoplasms
Susceptibility of C57BL/6 mice to tumorigenicity induced by dimethylnitrosamine and 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine in the neonatal bioassay.
Neoplasms
Susceptibility to childhood acute lymphoblastic leukemia: influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 genetic polymorphisms.
Neoplasms
Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases T1, P1, and M1 and cytochrome P450 2E1.
Neoplasms
Susceptibility to multiple cutaneous basal cell carcinomas: significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender.
Neoplasms
Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator.
Neoplasms
Sustained P450 expression and prodrug activation in bolus cyclophosphamide-treated cultured tumor cells. Impact of prodrug schedule on P450 gene-directed enzyme prodrug therapy.
Neoplasms
Synthesis and anticancer evaluation of novel triazole linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives as inhibitors of cell survival proteins and inducers of apoptosis in MCF-7 breast cancer cells.
Neoplasms
Synthesis and evaluation of azole-substituted tetrahydronaphthalenes as inhibitors of P450 arom, P450 17, and P450 TxA2.
Neoplasms
Synthesis and Evaluation of Novel Cholestanoheterocyclic Steroids as Anticancer Agents.
Neoplasms
Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites.
Neoplasms
Synthesis and structure-activity relationship studies of ?-naphthoflavone derivatives as CYP1B1 inhibitors.
Neoplasms
Synthesis of novel hybrid hetero-steroids: Molecular docking study augmented anti-proliferative properties against cancerous cells.
Neoplasms
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
Neoplasms
Synthesis, molecular modelling and CYP24A1 inhibitory activity of novel of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides.
Neoplasms
Synthetic Models Related to Methoxalen and Menthofuran-Cytochrome P450 (CYP) 2A6 Interactions. Benzofuran and Coumarin Derivatives as Potent and Selective Inhibitors of CYP2A6.
Neoplasms
T-2 toxin upregulates the expression of human cytochrome P450 1A1 (CYP1A1) by enhancing NRF1 and Sp1 interaction.
Neoplasms
Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer.
Neoplasms
Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue.
Neoplasms
Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450.
Neoplasms
Targeted delivery of CYP2E1 recombinant adenovirus to malignant melanoma by bone marrow-derived mesenchymal stem cells as vehicles.
Neoplasms
Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potential.
Neoplasms
Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development.
Neoplasms
Targeting cytochrome P450-dependent cancer cell mitochondria: cancer associated CYPs and where to find them.
Neoplasms
Targeting drug-metabolizing enzymes for effective chemoprevention and chemotherapy.
Neoplasms
The anti-tumorigenic properties of peroxisomal proliferator-activated receptor alpha are arachidonic acid epoxygenase-mediated.
Neoplasms
The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN) mice and pure enzymes.
Neoplasms
The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver.
Neoplasms
The antitumour activity of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole in human gastric cancer models is mediated by AhR signalling.
Neoplasms
The Association Between a Functional CYP1A1 Polymorphism and Colorectal Neoplasia Risk in Post Menopausal Women.
Neoplasms
The association study between CYP24A1 gene polymorphisms and risk of liver, lung and gastric cancer in a Chinese population.
Neoplasms
The associations between CYP24A1 polymorphisms and cancer susceptibility: A meta-analysis and trial sequential analysis.
Neoplasms
The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1.
Neoplasms
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells.
Neoplasms
The chronic spleen injury of mice following long-term exposure to titanium dioxide nanoparticles.
Neoplasms
The Consequences of Soluble Epoxide Hydrolase Deletion on Tumorigenesis and Metastasis in a Mouse Model of Breast Cancer.
Neoplasms
The contribution of cholesterol and epigenetic changes to the pathophysiology of breast cancer.
Neoplasms
The CYP19 TTTA repeat polymorphism is related to the prognosis of premenopausal stage I-II and operable stage III breast cancers.
Neoplasms
The CYP1A1 Ile462Val polymorphism and platinum resistance of epithelial ovarian neoplasms.
Neoplasms
The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.
Neoplasms
The CYP2A6*4 allele is determinant of S-1 pharmacokinetics in Japanese patients with non-small-cell lung cancer.
Neoplasms
The CYP2D6 extensive metabolizer genotype is associated with increased risk for bladder cancer.
Neoplasms
The cytochrome P450 enzyme CYP24A1 increases proliferation of mutant KRAS-dependent lung adenocarcinoma independently of its catalytic activity.
Neoplasms
The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production.
Neoplasms
The cytotoxicity of mitomycin C and adriamycin in genetically engineered V79 cell lines and freshly isolated rat hepatocytes.
Neoplasms
The down-regulation of the CYP2C19 gene is associated with aggressive tumor potential and the poorer recurrence-free survival of hepatocellular carcinoma.
Neoplasms
The effect of cigarette smoke on aryl hydrocarbon hydroxylase activity and cytochrome P450 content in rat liver and lung microsomes.
Neoplasms
The effect of exposure to crude oil on the immune system. Health implications for people living near oil exploration activities.
Neoplasms
The effect of genetic polymorphisms in the vinyl chloride metabolic pathway on mutagenic risk.
Neoplasms
The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis.
Neoplasms
The effects of anti-inflammatory agents on skin tumor initiation and aryl hydrocarbon hydroxylase.
Neoplasms
The effects of antioxidants on skin tumor initiation and aryl hydrocarbon hydroxylase.
Neoplasms
The effects of benzoflavones on polycyclic hydrocarbon metabolism and skin tumor initiation.
Neoplasms
The Effects of Intestinal LPS Exposure on Inflammatory Responses in a Porcine Enterohepatic Co-culture System.
Neoplasms
The ERR?-VDR axis promotes calcitriol degradation and estrogen signaling in breast cancer cells, while VDR-CYP24A1-ERR? overexpression correlates with poor prognosis in patients with basal-like breast cancer.
Neoplasms
The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer.
Neoplasms
The experimental antitumor agents Phortress and doxorubicin are equiactive against human-derived breast carcinoma xenograft models.
Neoplasms
The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue.
Neoplasms
The Expression Profiles of ADME Genes in Human Cancers and Their Associations with Clinical Outcomes.
Neoplasms
The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p.
Neoplasms
The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation.
Neoplasms
The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-?B-driven tumour intravasation.
Neoplasms
The human immunodeficiency virus protease inhibitor ritonavir is potentially active against urological malignancies.
Neoplasms
The immunohistochemical localization of drug-metabolizing enzymes in prostate cancer.
Neoplasms
The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen.
Neoplasms
The impact of p53 function on the metabolic activation of the carcinogenic air pollutant 3-nitrobenzanthrone and its metabolites 3-aminobenzanthrone and N-hydroxy-3-aminobenzanthrone in human cells.
Neoplasms
The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.
Neoplasms
The Inactivation of Human CYP2E1 by Phenethyl Isothiocyanate, a Naturally Occurring Chemopreventive Agent, and Its Oxidative Bioactivation.
Neoplasms
The inducible isoform of CREM (inducible cAMP early repressor, ICER) is a repressor of CYP19 rat ovarian promoter.
Neoplasms
The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo.
Neoplasms
The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis.
Neoplasms
The interleukin-2 receptor down-regulates the expression of cytochrome P450 in cultured rat hepatocytes.
Neoplasms
The involvement of secondary signaling molecules in cytochrome P-450 1A1-mediated inducible nitric oxide synthase expression in benzo(a)pyrene-treated rat polymorphonuclear leukocytes.
Neoplasms
The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.
Neoplasms
The modulatory properties of Si Jun Zi Tang enhancing anticancer of gefitinib by an integrating approach.
Neoplasms
The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748.
Neoplasms
The overexpression of int-5/Aromatase, a novel MMTV integration locus gene, is responsible for D2 mammary tumor cell proliferation.
Neoplasms
The Pathogenic Effects of Fusobacterium nucleatum on the Proliferation, Osteogenic Differentiation, and Transcriptome of Osteoblasts.
Neoplasms
The phospholipidosis-lnducing potential of the chemopotentiating drug, N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE, tesmilifene) correlates with its stimulation of phosphatidylserine synthesis and exposure on the plasma membrane in MCF-7 breast cancer cells.
Neoplasms
The polymorphism of CYP2E1 Rsa I/Pst I gene and susceptibility to respiratory system cancer: a systematic review and meta-analysis of 34 studies.
Neoplasms
The potential role of transcription factor aryl hydrocarbon receptor in downregulation of hepatic cytochrome P-450 during sepsis.
Neoplasms
The Preventive Effects of Quercetin on Preterm Birth Based on Network Pharmacology and Bioinformatics.
Neoplasms
The preventive factors for aspirin-induced peptic ulcer: aspirin ulcer and corpus atrophy.
Neoplasms
The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction.
Neoplasms
The prognostic value of differentially expressed CYP3A subfamily members for hepatocellular carcinoma.
Neoplasms
The Protective Effects of Water Extracts of Compound Turmeric Recipe on Acute Alcoholism: An Experimental Research Using a Mouse Model.
Neoplasms
The PstI/RsaI and DraI polymorphisms of CYP2E1 and head and neck cancer risk: a meta-analysis based on 21 case-control studies.
Neoplasms
The redox protein thioredoxin-1 regulates the constitutive and inducible expression of the estrogen metabolizing cytochromes P450 1B1 and 1A1 in MCF-7 human breast cancer cells.
Neoplasms
The renal medullary thick ascending limb as a model for understanding lipid mediators in sepsis.
Neoplasms
The role of aromatase and 17-beta-hydroxysteroid dehydrogenase type 1 mRNA expression in predicting the clinical outcome of human breast cancer.
Neoplasms
The role of aryl hydrocarbon hydroxylase in skin tumor initiation by 7,12-dimethylbenz(a)anthracene and 1,2,5,6-dibenzanthracene using DNA binding and thymidine-3H incorporation into DNA as criteria.
Neoplasms
The role of CYP2D6*4 variant in bladder cancer susceptibility in Tunisian patients.
Neoplasms
The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.
Neoplasms
The role of cytochrome P450 in cytotoxic bioactivation: future therapeutic directions.
Neoplasms
The role of cytochrome P450 in tumour development and progression and its potential in therapy.
Neoplasms
The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.
Neoplasms
The role of epidermal aryl hydrocarbon hydroxylase in the covalent binding of polycyclic hydrocarbon to DNA and its relationship to tumor initiation.
Neoplasms
The role of ethnicity in cancer susceptibility gene polymorphisms: the example of CYP1A1.
Neoplasms
The role of heterocyclic aromatic amines in colorectal cancer: the evidence from epidemiologic studies.
Neoplasms
The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells.
Neoplasms
The Selectivity of Austocystin D Arises from Cell-Line-Specific Drug Activation by Cytochrome P450 Enzymes.
Neoplasms
The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells.
Neoplasms
The synthesis of chalcones as anticancer prodrugs and their bioactivation in CYP1 expressing breast cancer cells.
Neoplasms
The transcriptomic responses of the ark shell, Anadara broughtonii, to sulfide and hypoxia exposure.
Neoplasms
The upregulating effect of dexamethasone on tumor necrosis factor production is mediated by a nitric oxide-producing cytochrome P450.
Neoplasms
The use of quantitative histological and molecular data for risk assessment and biologically based model development.
Neoplasms
Therapeutic-antagonists of oestrogens can be produced for cancer and other therapies using cytochromes P450 (CYP).
Neoplasms
Theta class glutathione S-transferase GSTT1 genotypes and susceptibility to cervical neoplasia: interactions with GSTM1, CYP2D6 and smoking.
Neoplasms
Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms.
Neoplasms
Time and dose-dependent modulation of phase 1 and phase 2 gene expression in response to treatment of MCF-7 cells with a natural anti-cancer agent.
Neoplasms
Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein.
Neoplasms
Tissue-selective regulation of aromatase expression by calcitriol: implications for breast cancer therapy.
Neoplasms
Tissue-specific induction of the carcinogen inducible cytochrome P450 isoform, P450IAI, in colonic epithelium.
Neoplasms
Tocilizumab: new drug. Rheumatoid arthritis: another 'mab', no therapeutic advantage.
Neoplasms
Toward individualized treatment: prediction of anticancer drug disposition and toxicity with pharmacogenetics.
Neoplasms
Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.
Neoplasms
Toxicogenomic evaluation of liver responses induced by acrylamide and glycidamide in male mouse liver.
Neoplasms
Transcript profiling of enzymes involved in detoxification of xenobiotics and reactive oxygen in human normal and simian virus 40 T antigen-immortalized oral keratinocytes.
Neoplasms
Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer.
Neoplasms
Transcriptome-based identification of new anti-anti-inflammatory and vasodilating properties of the n-3 fatty acid docosahexaenoic acid in vascular endothelial cell under proinflammatory conditions.
Neoplasms
Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung.
Neoplasms
Trends in co-prescribing of antidepressants and tamoxifen among women with breast cancer, 2004-2010.
Neoplasms
Truncal site and detoxifying enzyme polymorphisms significantly reduce time to presentation of further primary cutaneous basal cell carcinoma.
Neoplasms
Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction.
Neoplasms
Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers.
Neoplasms
Tumor necrosis factor as a potent inhibitor of adrenocorticotropin-induced cortisol production and steroidogenic P450 enzyme gene expression in cultured human fetal adrenal cells.
Neoplasms
Tumor necrosis factor-alpha activates transcription of inducible repressor form of 3',5'-cyclic adenosine 5'-monophosphate-responsive element binding modulator and represses P450 aromatase and inhibin alpha-subunit expression in rat ovarian granulosa cells by a p44/42 mitogen-activated protein kinase-dependent mechanism.
Neoplasms
Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver "stem-like" cells.
Neoplasms
Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression.
Neoplasms
Tumor promotion by an anticonvulsant agent, phenytoin, in mouse liver: correlation with CYP2B induction.
Neoplasms
Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer.
Neoplasms
Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver.
Neoplasms
Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine.
Neoplasms
Tumor-selective drug activation: a GDEPT approach utilizing cytochrome P450 1A1 and AQ4N.
Neoplasms
Tumors in brown bullheads in the Chesapeake Bay watershed: analysis of survey data from 1992 through 2006.
Neoplasms
Tumour Microenvironment: Roles of the Aryl Hydrocarbon Receptor, O-GlcNAcylation, Acetyl-CoA and Melatonergic Pathway in Regulating Dynamic Metabolic Interactions across Cell Types-Tumour Microenvironment and Metabolism.
Neoplasms
Tumour necrosis factor-? (TNF-?) enhances dietary carcinogen-induced DNA damage in colorectal cancer epithelial cells through activation of JNK signaling pathway.
Neoplasms
Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b.
Neoplasms
Tumour suppressor protein p53 regulates the stress activated bilirubin oxidase cytochrome P450 2A6.
Neoplasms
Typical airborne quinones modulate oxidative stress and cytokine expression in lung epithelial A549 cells.
Neoplasms
U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.
Neoplasms
Understanding Disease-Drug Interactions in Cancer Patients: Implications for Dosing Within the Therapeutic Window.
Neoplasms
Unexpected association between induction of immunity to the universal tumor antigen CYP1B1 and response to next therapy.
Neoplasms
Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway.
Neoplasms
Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients.
Neoplasms
Use of cell therapy as a means of targeting chemotherapy to inoperable pancreatic cancer.
Neoplasms
Use of duplex PCR-CTPP methods for CYP2E1RsaI/IL-2 T-330G and IL-1B C-31T/TNF-A T-1031C polymorphisms.
Neoplasms
Use of proteomics to identify mechanisms of hepatocellular carcinoma with the CYP2D6*10 polymorphism and identification of ANGPTL6 as a new diagnostic and prognostic biomarker.
Neoplasms
Use of replication-conditional adenovirus as a helper system to enhance delivery of P450 prodrug-activation genes for cancer therapy.
Neoplasms
Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads.
Neoplasms
Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines.
Neoplasms
Using bioinformatic approaches to identify pathways targeted by human leukemogens.
Neoplasms
Using salmonid microarrays to understand the dietary modulation of carcinogenesis in rainbow trout.
Neoplasms
Validation of model of cytochrome P450 2D6: an in silico tool for predicting metabolism and inhibition.
Neoplasms
Variant alleles of the CYP1B1 gene are associated with colorectal cancer susceptibility.
Neoplasms
Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China.
Neoplasms
Variation in CYP2A6 and nicotine metabolism among two American Indian tribal groups differing in smoking patterns and risk for tobacco-related cancer.
Neoplasms
Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors.
Neoplasms
VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells.
Neoplasms
Venetoclax plus cytochrome P450 inhibitors without ramp-up strategy led to low risk of tumor lysis syndrome in acute myeloid leukemia.
Neoplasms
Vincristine pharmacodynamics and pharmacogenetics in children with cancer: A limited-sampling, population modelling approach.
Neoplasms
Virilizing oncocytic adrenocortical carcinoma: clinical and immunohistochemical studies.
Neoplasms
Vitamin D receptor activation reduces VCaP xenograft tumor growth and counteracts ERG activity despite induction of TMPRSS2:ERG.
Neoplasms
Vitamin D Signaling Pathways Confer the Susceptibility of Esophageal Squamous Cell Carcinoma in a Northern Chinese Population.
Neoplasms
Vitamin D-neutralizing CYP24A1 expression, oncogenic mutation states and histological findings of human papillary thyroid cancer.
Neoplasms
Weight of evidence evaluation of potential human cancer risks from exposure to polychlorinated biphenyls: an update based on studies published since 2003.
Neoplasms
Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A.
Neoplasms
Xenobiotic metabolizing and antioxidant enzymes in normal and neoplastic human breast tissue.
Neoplasms
Xenobiotic metabolizing enzymes in genetically and chemically initiated mouse liver tumors.
Neoplasms
Xenobiotic-metabolising enzymes in patients with adenocarcinoma of the breast: Correlation with clinical stage and menopausal status.
Neoplasms
Xenobiotic-metabolizing enzymes and cancer risk: correspondence between genotype and phenotype.
Neoplasms
Xenobiotics and xenoestrogens in fish: modulation of cytochrome P450 and carcinogenesis.
Neoplasms
Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole.
Neoplasms
[9-Nitro- and 9-amino-ellipticines and derivatives: synthesis and pharmacologic properties]
Neoplasms
[A comparative study of induction regulation in cytochromes family 1 P450 in cell cultures at different stages of tumor transformation]
Neoplasms
[Activity and induction of CYP2B, CYP2C, and CYP3A in tissues of cyclophosphane-sensitive and resistant neoplasms and the liver of neoplasm-carrying mice]
Neoplasms
[Allelic distribution of the CYP1A1 in lung cancer patients, middle-aged tissue donors and in elderly people without cancer]
Neoplasms
[Apoptosis and differentiation induced with TCLA in rat glioblastoma cells in vitro]
Neoplasms
[Application of molecular biology to occupational health field--the frequency of gene polymorphism of cytochrome P450 1A1 and glutathione S-transferase M1 in patients with lung, oral and urothelial cancer]
Neoplasms
[Association between genetic polymorphisms of metabolic enzymes and susceptibility of colorectal cancer]
Neoplasms
[Clinical pharmacology and pharmacoepidemiology for medication safety in clinical settings].
Neoplasms
[Combined tumor chemotherapy/gene therapy based on the activation of antineoplastic agents by genetic constructions of cytochromes p450]
Neoplasms
[Construction of CYP2E1 recombinant adenovirus vector and its anti-tumor effects].
Neoplasms
[Effect of low doses of x-ray irradiation on the liver detoxication system in rats with transplanted Guerin's carcinoma].
Neoplasms
[EXOPHTHALMOS, EXCEPTIONAL REVELATORY SIGN OF A TUMOR OF THE OLFACTIVE PLACODE. ESTHESIONEUROEPITHELIOMA. HISTOLOGICAL RELATION OF THIS TUMOR TO NERVOUS RETINAL TUMORS.]
Neoplasms
[Expression of cytochrome P450 enzymes in human nasopharyngeal carcinoma and non-cancerous nasopharynx tissue]
Neoplasms
[Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitro].
Neoplasms
[First results on the influence of polymorphisms at glutathione S-transferase, cytochrome P450, and tumor necrosis factor gene loci on the development of multiple head and neck cancer]
Neoplasms
[Genetic and phenotypic polymorphisms in carcinogen-metabolizing enzymes and cancer susceptibility]
Neoplasms
[Genetic polymorphism of steroidogenic enzymes and steroid receptor level in tumors of the reproductive system]
Neoplasms
[Genetic polymorphisms of cytochrome P450 2E1 and glutathione S-transferase P1 and susceptibility to esophageal cancer]
Neoplasms
[Growth inhibition and multidrug resistance-reversing effect of tanshinone I A on human breast cancer cell with estrogen receptor negative]
Neoplasms
[Immunologic and genetic markers of exposure to aromatic hydrocarbons in workers].
Neoplasms
[Increase of general toxic effects and decrease of hepatocarcinogenic effects of diethylnitrosamine administered to mice in conjunction with isopropanol].
Neoplasms
[Influence of genetic polymorphism of CYP1A1 and GSTM1 on the levels of urinary 1-hydroxypyrene]
Neoplasms
[Influence of glutathione s-transferase and cytochrome p450 polymorphisms on prognosis of head and neck cancer]
Neoplasms
[Inhibitory effect of flavonoids from Scutellariae Radix on human cytochrome P450 1A].
Neoplasms
[Interindividual variation of pharmacokinetic disposition of and clinical responses to opioid analgesics in cancer pain patients].
Neoplasms
[Malignant tumor's of nasal fossae: anatomoclinic's study and a new classification: study about 21 cases]
Neoplasms
[Mechanism of the mutagenic/carcinogenic action of cigarette smoke at the pulmonary level: enzymatic induction, activation and detoxification]
Neoplasms
[Progress in the study of heterogeneous nuclear ribonucleoprotein and its relation with diseases]
Neoplasms
[Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma]
Neoplasms
[Relationship between the gene polymorphisms of oxidative metabolism enzyme of exogenous chemicals and the susceptibility to neoplasms].
Neoplasms
[Role of aryl hydrocarbon hydroxylase in developing laryngeal cancer among smokers]
Neoplasms
[Study on the relationship between familial clustering of hepatocellular carcinoma and polymorphism of cytochrome P450 2E1 gene in Zhuang population, Guangxi]
Neoplasms
[Susceptibility to bronchial cancer: an example of genetic-environmental interaction]
Neoplasms
[The induction of Guerin's carcinoma cytochrome p450 hydroxylase activity by retinoids].
Neoplasms
[The strategic use of genetic polymorphisms in carcinogen metabolizing enzyme for prevention of cancer]
Neoplasms
[Tumor development and monooxygenase activity in the liver of mice exposed to the combined action of N-nitrosodimethylamine and benz(a)pyrene]
Neoplasms, Germ Cell and Embryonal
Risk of testicular germ cell cancer in relation to variation in maternal and offspring cytochrome p450 genes involved in catechol estrogen metabolism.
Neoplasms, Second Primary
Genetic sequence variants in vitamin D metabolism pathway genes, serum vitamin D level and outcome in head and neck cancer patients.
Neoplasms, Squamous Cell
Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue.
Neoplasms, Squamous Cell
Association of cytochrome P450 2E1 polymorphisms and head and neck squamous cell cancer.
Neoplasms, Squamous Cell
Cytochrome P450 1B1, a new keystone in gene-environment interactions related to human head and neck cancer?
Neoplasms, Squamous Cell
Cytochrome p450 and glutathione transferase expression in squamous cell cancer.
Neoplasms, Squamous Cell
Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in Xinjiang, China.
Neoplasms, Squamous Cell
Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6.
Nephritis, Interstitial
Long-term clinical safety of Clindamycin and Rifampicin combination for the treatment of Hidradenitis suppurativa: a critically appraised topic.
Nephrocalcinosis
1,25-(OH)2D-24 Hydroxylase (CYP24A1) Deficiency as a Cause of Nephrolithiasis.
Nephrocalcinosis
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
Nephrocalcinosis
A novel CYP24A1 genotype associated to a clinical picture of hypercalcemia, nephrolithiasis and low bone mass.
Nephrocalcinosis
A rapid screening of a recurrent CYP24A1 pathogenic variant opens the way to molecular testing for Idiopathic Infantile Hypercalcemia (IIH).
Nephrocalcinosis
A Young Woman with Recurrent Gestational Hypercalcemia and Acute Pancreatitis Due to CYP24A1 Deficiency.
Nephrocalcinosis
Calcium and bone homeostasis in heterozygous carriers of CYP24A1 mutations: A cross-sectional study.
Nephrocalcinosis
Erratum: Medullary nephrocalcinosis in an adult patient with idiopathic infantile hypercalcaemia and a novel CYP24A1 mutation.
Nephrocalcinosis
Idiopathic infantile hypercalcemia: mutations in SLC34A1 and CYP24A1 in two siblings and fathers.
Nephrocalcinosis
Kidney function and influence of sunlight exposure in patients with impaired 24-hydroxylation of vitamin D due to CYP24A1 mutations.
Nephrocalcinosis
Loss-of-function mutations of CYP24A1, the vitamin D 24- hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis.
Nephrocalcinosis
Medullary nephrocalcinosis in an adult patient with idiopathic infantile hypercalcaemia and a novel CYP24A1 mutation.
Nephrocalcinosis
Mutational Spectrum of CYP24A1 Gene in a Cohort of Italian Patients with Idiopathic Infantile Hypercalcemia.
Nephrocalcinosis
Novel CYP24A1 Mutation in a Young Male Patient with Nephrolithiasis: Case Report.
Nephrocalcinosis
Re: Loss-of-Function Mutations of CYP24A1, the Vitamin D 24-hydroxylase Gene, Cause Long-standing Hypercalciuric Nephrolithiasis and Nephrocalcinosis.
Nephrocalcinosis
Successful treatment of hypercalcaemia associated with a CYP24A1 mutation with fluconazole.
Nephrocalcinosis
The hypercalcaemia of CYP24A1 inactivation: new ways to improve diagnosis and treatment.
Nephrolithiasis
1,25-(OH)2D-24 Hydroxylase (CYP24A1) Deficiency as a Cause of Nephrolithiasis.
Nephrolithiasis
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
Nephrolithiasis
A Case of "Late Onset" Idiopathic Infantile Hypercalcemia Secondary to Mutations in The CYP24A1 Gene.
Nephrolithiasis
A Case Report of Compound Heterozygous CYP24A1 Mutations Leading to Nephrolithiasis Successfully Treated with Ketoconazole.
Nephrolithiasis
A novel CYP24A1 genotype associated to a clinical picture of hypercalcemia, nephrolithiasis and low bone mass.
Nephrolithiasis
A Young Woman with Recurrent Gestational Hypercalcemia and Acute Pancreatitis Due to CYP24A1 Deficiency.
Nephrolithiasis
Clinical and biochemical phenotypes of adults with monoallelic and biallelic CYP24A1 mutations: evidence of gene dose effect.
Nephrolithiasis
CYP24A1 loss of function: Clinical phenotype of monoallelic and biallelic mutations.
Nephrolithiasis
Erratum to: A novel CYP24A1 genotype associated to a clinical picture of hypercalcemia, nephrolithiasis and low bone mass.
Nephrolithiasis
Hypercalcemia, Hypercalciuria, and Elevated Calcitriol Concentrations with Autosomal Dominant Transmission Due to CYP24A1 Mutations: Effects of Ketoconazole Therapy.
Nephrolithiasis
Iatrogenic vitamin D toxicity in an infant - a case report and review of literature.
Nephrolithiasis
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
Nephrolithiasis
Loss-of-function mutations of CYP24A1, the vitamin D 24- hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis.
Nephrolithiasis
Mutational Spectrum of CYP24A1 Gene in a Cohort of Italian Patients with Idiopathic Infantile Hypercalcemia.
Nephrolithiasis
Novel CYP24A1 Mutation in a Young Male Patient with Nephrolithiasis: Case Report.
Nephrolithiasis
Re: Loss-of-Function Mutations of CYP24A1, the Vitamin D 24-hydroxylase Gene, Cause Long-standing Hypercalciuric Nephrolithiasis and Nephrocalcinosis.
Nephrolithiasis
Single-nucleotide polymorphisms in the UDP-glucuronosyltransferase 1A-3' untranslated region are associated with atazanavir-induced nephrolithiasis in patients with HIV-1 infection: a pharmacogenetic study.
Nephrolithiasis
Successful treatment of hypercalcaemia associated with a CYP24A1 mutation with fluconazole.
Nephrolithiasis
Therapy-Resistant Hypercalcemia in a Patient with Inactivating CYP24A1 Mutation and Recurrent Nephrolithiasis: Beware of Concomitant Hyperparathyroidism.
Nephrosis
Contribution of down-regulation of intestinal and hepatic cytochrome P450 3A to increased absorption of cyclosporine A in a rat nephrosis model.
Nephrotic Syndrome
Correction to: CYP3A5 and CYP3A7 genetic polymorphisms affect tacrolimus concentration in pediatric patients with nephrotic syndrome.
Nephrotic Syndrome
Cytochrome P450 2B1 mediates oxidant injury in puromycin-induced nephrotic syndrome.
Nephrotic Syndrome
Cytochrome-P450 2B1 gene silencing attenuates puromycin aminonucleoside-induced cytotoxicity in glomerular epithelial cells.
Nephrotic Syndrome
Diltiazem on tacrolimus exposure and dose sparing in Chinese pediatric primary nephrotic syndrome: impact of CYP3A4, CYP3A5, ABCB1, and SLCO1B3 polymorphisms.
Nephrotic Syndrome
Dosage Optimization Based on Population Pharmacokinetic Analysis of Tacrolimus in Chinese Patients with Nephrotic Syndrome.
Nephrotic Syndrome
Impaired testicular cytochrome P450 side-chain-cleavage (P450scc) and steroidogenic acute regulatory (StAR) protein expression in rats with nephrotic syndrome.
Nephrotic Syndrome
MDR-1 and CYP3A5 Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome: Impact on Susceptibility and Response to Steroids (Preliminary Results).
Nephrotic Syndrome
Optimization of initial dosing scheme of tacrolimus in pediatric refractory nephrotic syndrome patients based on CYP3A5 genotype and coadministration with wuzhi-capsule.
Nephrotic Syndrome
Steroidogenic impairment due to reduced ovarian transcription of cytochrome P450 side-chain-cleavage (P450scc) and steroidogenic acute regulatory protein (StAR) during experimental nephrotic syndrome.
Nervous System Diseases
Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders.
Nervous System Diseases
Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of human cytochrome P450 CYP2D6 gene.
Nervous System Diseases
Psychotropic drugs and CYP2D6 in late-life psychiatric and neurological disorders. What do we know?
Neural Tube Defects
Pharmacogenetic screening for susceptibility to fetal malformations in women.
Neuralgia
Effects of type 1 and type 2 diabetes on the pharmacokinetics of tramadol enantiomers in patients with neuropathic pain phenotyped as cytochrome P450 2D6 extensive metabolizers.
Neuralgia
Impact of fraction unbound, CYP3A, and CYP2D6 in vivo activities, and other potential covariates to the clearance of tramadol enantiomers in patients with neuropathic pain.
Neuralgia
Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain.
Neuralgia
Severe Vincristine-induced Neuropathic Pain in a CYP3A5 Nonexpressor With Reduced CYP3A4/5 Activity: Case Study.
Neuralgia
The gene regulatory network in different brain regions of neuropathic pain mouse models.
Neuralgia
[Desvenlafaxine and neuropathic pain: additional clinical benefits of a second generation serotonin-noradrenaline reuptake inhibitor].
Neuralgia, Postherpetic
CYP2D6*4 polymorphism, tramadol treatment and its clinical impact in patients with postherpetic neuralgia.
Neuroblastoma
?-Naphtoflavone and Ethanol Induce Cytochrome P450 and Protect towards MPP? Toxicity in Human Neuroblastoma SH-SY5Y Cells.
Neuroblastoma
Acetaminophen induces human neuroblastoma cell death through NFKB activation.
Neuroblastoma
Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics.
Neuroblastoma
Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells.
Neuroblastoma
Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells.
Neuroblastoma
P450 inhibitor ketoconazole increased the intratumor drug levels and antitumor activity of fenretinide in human neuroblastoma xenograft models.
Neurocysticercosis
Albendazole metabolism in patients with neurocysticercosis: antipyrine as a multifunctional marker drug of cytochrome P450.
Neurodegenerative Diseases
?-Naphthoflavone and Ethanol Reverse Mitochondrial Dysfunction in A Parkinsonian Model of Neurodegeneration.
Neurodegenerative Diseases
ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders.
Neurodegenerative Diseases
APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson's disease in a Japanese population.
Neurodegenerative Diseases
Brain sterol flux mediated by cytochrome P450 46A1 affects membrane properties and membrane-dependent processes.
Neurodegenerative Diseases
CYP7B1: novel mutations and magnetic resonance spectroscopy abnormalities in hereditary spastic paraplegia type 5A.
Neurodegenerative Diseases
Cytochrome P450 eicosanoids in cerebrovascular function and disease.
Neurodegenerative Diseases
Cytochrome P450 in the central nervous system as a therapeutic target in neurodegenerative diseases.
Neurodegenerative Diseases
Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration.
Neurodegenerative Diseases
Drugs and Scaffold That Inhibit Cytochrome P450 27A1 In Vitro and In Vivo.
Neurodegenerative Diseases
Excretion, Metabolism and Cytochrome P450 Inhibition of Methyl 3,4-Dihydroxybenzoate (MDHB): A Potential Candidate to Treat Neurodegenerative Diseases.
Neurodegenerative Diseases
Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice.
Neurodegenerative Diseases
Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration.
Neurodegenerative Diseases
Localization of NADPH cytochrome P450 oxidoreductase in rat brain by immunohistochemistry and in situ hybridization and a comparison with the distribution of neuronal NADPH-diaphorase staining.
Neurodegenerative Diseases
Metabolism of xenobiotics in the central nervous system: implications and challenges.
Neurodegenerative Diseases
The lack of Irs2 induces changes in the immunocytochemical expression of aromatase in the mouse retina.
Neuroinflammatory Diseases
Central CYP1B1 (Cytochrome P450 1B1)-Estradiol Metabolite 2-Methoxyestradiol Protects From Hypertension and Neuroinflammation in Female Mice.
Neuroinflammatory Diseases
Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases.
Neuroinflammatory Diseases
Cytochrome P450 eicosanoids in cerebrovascular function and disease.
Neuroinflammatory Diseases
Neuroinflammation is able to downregulate cytochrome P450 epoxygenases 2J3 and 2C11 in the rat brain.
Neuroleptic Malignant Syndrome
A case study: neuroleptic malignant syndrome with risperidone and CYP2D6 gene variation.
Neuroleptic Malignant Syndrome
CYP2D6 gene deletion allele in patients with neuroleptic malignant syndrome: preliminary report.
Neuroleptic Malignant Syndrome
CYP2D6 genotype and possible susceptibility to the neuroleptic malignant syndrome.
Neuroleptic Malignant Syndrome
CYP2D6 Hhal genotype and the neuroleptic malignant syndrome (NMS)
Neuroleptic Malignant Syndrome
Effects of CYP2D6 polymorphisms on neuroleptic malignant syndrome.
Neuroleptic Malignant Syndrome
Lack of association in Japanese patients between neuroleptic malignant syndrome and a debrisoquine 4-hydroxylase genotype with low enzyme activity.
Neuroleptic Malignant Syndrome
Mutation involving cytochrome P450IID6 in two Japanese patients with neuroleptic malignant syndrome.
Neuroleptic Malignant Syndrome
Neuroleptic malignant syndrome and hydroxylase gene mutations: no association with CYP2D6A or CYP2D6B.
Neuroleptic Malignant Syndrome
Neuroleptic malignant syndrome in an adolescent with CYP2D6 deficiency.
Neurologic Manifestations
c.1263+1G>A Is a Latent Hotspot for CYP27A1 Mutations in Chinese Patients With Cerebrotendinous Xanthomatosis.
Neurologic Manifestations
Cerebrotendinous Xanthomatosis ataxia responsive to CDCA and Riluzole.
Neurologic Manifestations
Chenodeoxycholic Acid: An Update on Its Therapeutic Applications.
Neuroma, Acoustic
Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors.
Neutropenia
A physiologically based pharmacokinetic - pharmacodynamic modelling approach to predict incidence of neutropenia as a result of drug-drug interactions of paclitaxel in cancer patients.
Neutropenia
Comparison of docetaxel/cisplatin dosages of 75/60 and 60/60 mg/m(2) for the treatment of non-small cell lung cancer.
Neutropenia
Dose-finding study on adjuvant chemotherapy with S-1 plus oxaliplatin for gastric cancer.
Neutropenia
Drug-related genetic polymorphisms affecting severe chemotherapy-induced neutropenia in breast cancer patients: A hospital-based observational study.
Neutropenia
Pharmacogenetic determinants of outcomes on triplet hepatic artery infusion and intravenous cetuximab for liver metastases from colorectal cancer (European trial OPTILIV, NCT00852228).
Neutropenia
Plausible drug interaction between cyclophosphamide and voriconazole via inhibition of CYP2B6.
Neutropenia
Pretreatment H2 receptor antagonists that differ in P450 modulation activity: comparative effects on paclitaxel clearance rates and neutropenia.
Neutropenia
Prospective evaluation of the drug-metabolizing enzyme polymorphisms and toxicity profile of docetaxel in Korean patients with operable lymph node-positive breast cancer receiving adjuvant chemotherapy.
Neutropenia
Randomized pharmacokinetic and pharmacodynamic study of docetaxel: dosing based on body-surface area compared with individualized dosing based on cytochrome P450 activity estimated using a urinary metabolite of exogenous cortisol.
Neutropenia
Role of pharmacogenetics on adjuvant chemotherapy-induced neutropenia in Chinese breast cancer patients.
Neutropenia
[Validation of genetic polymorphisms associated to the toxicity of chemotherapy in colorectal cancer patients].
Nevus
CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies.
Nevus
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
Nevus, Pigmented
CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies.
Non-alcoholic Fatty Liver Disease
A case-control study on the effect of metabolic gene polymorphisms, nutrition, and their interaction on the risk of non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen.
Non-alcoholic Fatty Liver Disease
A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma.
Non-alcoholic Fatty Liver Disease
A novel sesquiterpene glycoside from Loquat leaf alleviates oleic acid-induced steatosis and oxidative stress in HepG2 cells.
Non-alcoholic Fatty Liver Disease
A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice.
Non-alcoholic Fatty Liver Disease
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Non-alcoholic Fatty Liver Disease
Bariatric surgery-induced weight loss reduces hepatic lipid peroxidation levels and affects hepatic cytochrome P-450 protein content.
Non-alcoholic Fatty Liver Disease
Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation.
Non-alcoholic Fatty Liver Disease
CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model.
Non-alcoholic Fatty Liver Disease
CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis.
Non-alcoholic Fatty Liver Disease
CYP2E1 and Oxidant Stress in Alcoholic and Non-Alcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
CYP3A suppression during diet-induced nonalcoholic fatty liver disease is independent of PXR regulation.
Non-alcoholic Fatty Liver Disease
Cytochrome P450 1A1 (CYP1A1) Catalyzes Lipid Peroxidation of Oleic Acid-Induced HepG2 Cells.
Non-alcoholic Fatty Liver Disease
Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice.
Non-alcoholic Fatty Liver Disease
Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.
Non-alcoholic Fatty Liver Disease
Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications.
Non-alcoholic Fatty Liver Disease
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Non-alcoholic Fatty Liver Disease
Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis.
Non-alcoholic Fatty Liver Disease
Diet-induced non-alcoholic fatty liver disease affects expression of major cytochrome P450 genes in a mouse model.
Non-alcoholic Fatty Liver Disease
Effect of Chinese Herbal Monomer Hairy Calycosin on Nonalcoholic Fatty Liver Rats and its Mechanism.
Non-alcoholic Fatty Liver Disease
Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA?treated HepG2 cells.
Non-alcoholic Fatty Liver Disease
Effects of Nonalcoholic Fatty Liver Disease on Hepatic CYP2B1 and in Vivo Bupropion Disposition in Rats Fed a High-Fat or Methionine/Choline-Deficient Diet.
Non-alcoholic Fatty Liver Disease
Effects of Short- and Long-Term Soy Protein Feeding on Hepatic Cytochrome P450 Expression in Obese Nonalcoholic Fatty Liver Disease Rat Model.
Non-alcoholic Fatty Liver Disease
Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice.
Non-alcoholic Fatty Liver Disease
Establishment of an ex Vivo Model of Nonalcoholic Fatty Liver Disease Using a Tissue-Engineered Liver.
Non-alcoholic Fatty Liver Disease
Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation.
Non-alcoholic Fatty Liver Disease
Expression of Cytochrome P450 2A5 in a C57BL/6J Mouse Model of Nonalcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress.
Non-alcoholic Fatty Liver Disease
Gender differences in diet-induced steatotic disease in Cyp2b-null mice.
Non-alcoholic Fatty Liver Disease
Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.
Non-alcoholic Fatty Liver Disease
Hepatic cytochrome P450 2E1 activity in nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis.
Non-alcoholic Fatty Liver Disease
Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis.
Non-alcoholic Fatty Liver Disease
Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Hepatic Lipid Peroxidation and Cytochrome P-450 2E1 in Pediatric Nonalcoholic Fatty Liver Disease and Its Subtypes.
Non-alcoholic Fatty Liver Disease
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.
Non-alcoholic Fatty Liver Disease
Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat.
Non-alcoholic Fatty Liver Disease
Hepatoprotective Effect of Loquat Leaf Flavonoids in PM2.5-Induced Non-Alcoholic Fatty Liver Disease via Regulation of IRs-1/Akt and CYP2E1/JNK Pathways.
Non-alcoholic Fatty Liver Disease
Hepatoprotective Effect of Seed Coat ofEuryale ferox Extract in Non-alcoholic Fatty Liver Disease Induced by High-fat Diet in Mice by Increasing IRs-1 and Inhibiting CYP2E1.
Non-alcoholic Fatty Liver Disease
High-Selectivity Fluorescent Reporter toward Peroxynitrite in a Coexisting Nonalcoholic Fatty Liver and Drug-Induced Liver Diseases Model.
Non-alcoholic Fatty Liver Disease
Higher chlorzoxazone clearance in obese children compared with nonobese peers.
Non-alcoholic Fatty Liver Disease
Histone Methyltransferase G9a Regulates Expression of Nuclear Receptors and Cytochrome P450 Enzymes in HepaRG Cells at Basal Level and in Fatty Acid Induced Steatosis.
Non-alcoholic Fatty Liver Disease
Importance of genetic polymorphisms in liver transplantation outcomes.
Non-alcoholic Fatty Liver Disease
In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice.
Non-alcoholic Fatty Liver Disease
Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role.
Non-alcoholic Fatty Liver Disease
Influence of royal jelly on mouse hepatic gene expression and safety assessment with a DNA microarray.
Non-alcoholic Fatty Liver Disease
Integrated analysis of hepatic mRNA and miRNA profiles identified molecular networks and potential biomarkers of NAFLD.
Non-alcoholic Fatty Liver Disease
Investigation of nonalcoholic fatty liver disease-induced drug metabolism by comparative global toxicoproteomics.
Non-alcoholic Fatty Liver Disease
Molecular pathways involved in the improvement of non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Non-alcoholic Fatty Liver Disease
New insight and potential therapy for NAFLD: CYP2E1 and flavonoids.
Non-alcoholic Fatty Liver Disease
NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesangial cell activation and proximal tubular toxicity.
Non-alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) - pathogenesis, classification, and effect on drug metabolizing enzymes and transporters.
Non-alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model.
Non-alcoholic Fatty Liver Disease
Nonalcoholic Fatty Liver Disease (NAFLD) and Hepatic Cytochrome P450 (CYP) Enzymes.
Non-alcoholic Fatty Liver Disease
Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients.
Non-alcoholic Fatty Liver Disease
Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis.
Non-alcoholic Fatty Liver Disease
Pharmacological Mechanisms Underlying the Hepatoprotective Effects of Ecliptae herba on Hepatocellular Carcinoma.
Non-alcoholic Fatty Liver Disease
Pioglitazone, quercetin and hydroxy citric acid effect on cytochrome P450 2E1 (CYP2E1) enzyme levels in experimentally induced non alcoholic steatohepatitis (NASH).
Non-alcoholic Fatty Liver Disease
Potential role of gut microbiota, the proto-oncogene PIKE (Agap2) and cytochrome P450 CYP2W1 in promotion of liver cancer by alcoholic and nonalcoholic fatty liver disease and protection by dietary soy protein.
Non-alcoholic Fatty Liver Disease
Protective effect and mechanism of Qiwei Tiexie capsule on 3T3-L1 adipocytes cells and rats with nonalcoholic fatty liver disease by regulating LXR?, PPAR?, and NF-?B-iNOS-NO signaling pathways.
Non-alcoholic Fatty Liver Disease
Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation.
Non-alcoholic Fatty Liver Disease
Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis.
Non-alcoholic Fatty Liver Disease
Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Regulation of the cytochrome P450 epoxyeicosanoid pathway is associated with distinct histologic features in pediatric non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients.
Non-alcoholic Fatty Liver Disease
Relevance of CYP2E1 to Non-alcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
Role of CYP2E1 in mitochondrial dysfunction and hepatic tissue injury in alcoholic and non-alcoholic diseases.
Non-alcoholic Fatty Liver Disease
Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, nonalcoholic steatohepatitis obese women.
Non-alcoholic Fatty Liver Disease
Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD.
Non-alcoholic Fatty Liver Disease
Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers.
Non-alcoholic Fatty Liver Disease
TA allele of rs2070673 in the CYP2E1 gene is associated with lobular inflammation and nonalcoholic steatohepatitis in patients with biopsy-proven nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice.
Non-alcoholic Fatty Liver Disease
Targeting CYP4A attenuates hepatic steatosis in a novel multicellular organotypic liver model.
Non-alcoholic Fatty Liver Disease
The 13C-Caffeine Breath Test Detects Significant Fibrosis in Patients With Nonalcoholic Steatohepatitis.
Non-alcoholic Fatty Liver Disease
The CYP2E1 knockout delivers another punch: first ASH, now NASH. Alcoholic steatohepatitis. Nonalcoholic steatohepatitis.
Non-alcoholic Fatty Liver Disease
The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.
Non-alcoholic Fatty Liver Disease
The generation of carcinogenic etheno-DNA adducts in the liver of patients with nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
The preventive effect of phenolic-rich extracts from Chinese sumac fruits against nonalcoholic fatty liver disease in rats induced by a high-fat diet.
Non-alcoholic Fatty Liver Disease
Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Tobacco Smoke and CYP1A2 Activity in a US Population with Normal Liver Enzyme Levels.
Non-alcoholic Fatty Liver Disease
Total sesquiterpene glycosides from Loquat (Eriobotrya japonica) leaf alleviate high-fat diet induced non-alcoholic fatty liver disease through cytochrome P450 2E1 inhibition.
Non-alcoholic Fatty Liver Disease
Transcriptional Repression of CYP3A4 by Increased miR-200a-3p and miR-150-5p Promotes Steatosis in vitro.
Non-alcoholic Fatty Liver Disease
Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models.
Non-alcoholic Fatty Liver Disease
[Experimental study on inhibitory effect of Chinese herbal compound on hepatocyte cytochrome P450 II E1 expression in rat model of nonalcoholic fatty liver]
Non-alcoholic Fatty Liver Disease
[Influence of electroacupuncture on hepatic cytochrome P450 1 A 1 expression and lipid peroxidation in nonalcoholic fatty liver rats]
Non-alcoholic Fatty Liver Disease
[The role of cytochrome P450 in nonalcoholic fatty liver induced by high-fat diet: a gene expression profile analysis].
Non-ST Elevated Myocardial Infarction
Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) registry.
Non-ST Elevated Myocardial Infarction
Letter by Hnid and Chtioui regarding article, "Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Registry".
Obesity
A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity.
Obesity
A genetic polymorphism in the regulatory sequences of human CYP2E1: association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake.
Obesity
Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect.
Obesity
ADH2 and CYP2E1 genetic polymorphisms: risk factors for alcohol-related birth defects.
Obesity
Altered activity of cytochrome P450 in alcoholic fatty liver exposed to ischemia/reperfusion.
Obesity
Altered cytochrome P450 activities and expression levels in the liver and intestines of the monosodium glutamate-induced mouse model of human obesity.
Obesity
Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.
Obesity
Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis.
Obesity
Characterization of cytochrome P450 and glutathione S-transferase activity and expression in male and female ob/ob mice.
Obesity
Characterization of hepatic cytochrome P450 isozyme composition in the transgenic rat expressing low level human growth hormone.
Obesity
Coffee intake and risk of obesity, metabolic syndrome and type 2 diabetes: a Mendelian randomization study.
Obesity
Comparing the protective effects of three sulfur compounds against acrylonitrile-induced acute toxicity in CYP2E1-induced rats.
Obesity
Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice.
Obesity
CYP1B1 deficiency ameliorates obesity and glucose intolerance induced by high fat diet in adult C57BL/6J mice.
Obesity
CYP1B1 deiciency ameliorates learning and memory deficits caused by high fat diet in mice.
Obesity
CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model.
Obesity
Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis.
Obesity
CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.
Obesity
CYP2E1 RsaI and 96-bp insertion genetic polymorphisms associated with risk for colorectal cancer.
Obesity
CYP450 activities before and after Roux-en-Y gastric bypass: correlation with their intestinal and liver content.
Obesity
Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance.
Obesity
Cytochrome P450 2E1 (CYP2E1) positively regulates lipid catabolism and induces browning in 3T3-L1 white adipocytes.
Obesity
Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.
Obesity
Defective expression of cytochrome P450 proteins in the liver of the genetically obese Zucker rat.
Obesity
Dietary-Induced Obesity, Hepatic Cytochrome P450, and Lidocaine Metabolism: Comparative Effects of High-Fat Diets in Mice and Rats and Reversibility of Effects With Normalization of Diet.
Obesity
Differences in Early Acetaminophen Hepatotoxicity between Obese ob/ob and db/db Mice.
Obesity
Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines.
Obesity
Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity.
Obesity
Effect of genetic obesity and experimental diabetes on hepatic microsomal mixed function oxidase activities.
Obesity
Effect of nutritional obesity on the induction of CYP2B enzymes following phenobarbital treatment.
Obesity
Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation.
Obesity
Evaluation of the Associations of GC and CYP2R1 Genes and Gene-Obesity Interactions with Type 2 Diabetes Risk in a Chinese Rural Population.
Obesity
Expression of a male-specific cytochrome P450 isozyme (CYP2C11) in fa/fa Zucker rats: effect of phenobarbital treatment.
Obesity
Expression of the CYP3A and CYP2C11 enzymes in a nutritionally obese rodent model: response to phenobarbital treatment.
Obesity
Extracting time-dependent obese-diabetic specific networks in hepatic proteome analysis.
Obesity
Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity.
Obesity
Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells.
Obesity
Genetic polymorphisms and obesity influence estradiol decline during the menopause.
Obesity
Haplotypes of CYP1B1 and CCDC57 genes in an Afro-Caribbean female population with uterine leiomyoma.
Obesity
High-Fat Diet Feeding Alters Expression of Hepatic Drug-Metabolizing Enzymes in Mice.
Obesity
Histone Methyltransferase G9a Regulates Expression of Nuclear Receptors and Cytochrome P450 Enzymes in HepaRG Cells at Basal Level and in Fatty Acid Induced Steatosis.
Obesity
Imidacloprid as reproductive toxicant and endocrine disruptor: investigations in laboratory animals.
Obesity
Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role.
Obesity
Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK.
Obesity
Lipidomic profiling of high-fat diet-induced obesity in mice: Importance of cytochrome P450-derived fatty acid epoxides.
Obesity
Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition.
Obesity
Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity.
Obesity
Midazolam pharmacokinetics in morbidly obese patients following semi-simultaneous oral and intravenous administration: a comparison with healthy volunteers.
Obesity
Non-alcoholic Steatohepatitis (NASH) Drug Discovery - Building a Consensus on ADME Screening Tools and Clinical Pharmacology Strategies to Aid Candidate Development.
Obesity
Obesity and fatty liver are prevented by inhibition of the aryl hydrocarbon receptor in both female and male mice.
Obesity
Obesity and Inflammation and Altered Clopidogrel Pharmacokinetics and Pharmacodynamics.
Obesity
Obesity and Insulin Resistance: Associations with Chronic Inflammation, Genetic and Epigenetic Factors.
Obesity
Obesity as a risk factor for drug-induced organ injury. VI. Increased hepatic P450 concentration and microsomal ethanol oxidizing activity in the obese overfed rat.
Obesity
Obesity during pregnancy affects sex steroid concentrations depending on fetal gender.
Obesity
Obesity is associated with a slower response to initial phenprocoumon therapy whereas CYP2C9 genotypes are not.
Obesity
Obesity Represses CYP2R1, the Vitamin D 25-Hydroxylase, in the Liver and Extrahepatic Tissues.
Obesity
Overexpression of cholesterol 7?-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis.
Obesity
Permanent uncoupling of male-specific CYP2C11 transcription/translation by perinatal glutamate.
Obesity
Pharmacokinetics in Morbid Obesity: Influence of Two Bariatric Surgery Techniques on Paracetamol and Caffeine Metabolism.
Obesity
Progressive obesity alters ovarian insulin, phosphatidylinositol-3 kinase, and chemical metabolism signaling pathways and potentiates ovotoxicity induced by phosphoramide mustard in mice.
Obesity
Progressive obesity alters ovarian insulin, phosphatidylinositol-3 kinase, and chemical metabolism signaling pathways and potentiates ovotoxicity induced by phosphoramide mustard in mice.
Obesity
Research Progress on the Relationship between Obesity-Inflammation-Aromatase Axis and Male Infertility.
Obesity
Reversal of obesity and liver steatosis in mice via inhibition of aryl hydrocarbon receptor and altered gene expression of CYP1B1, PPAR?, SCD1, and osteopontin.
Obesity
Role of CYP2E1 in mitochondrial dysfunction and hepatic tissue injury in alcoholic and non-alcoholic diseases.
Obesity
Sterol 27-Hydroxylase Polymorphism Significantly Associates With Shorter Telomere, Higher Cardiovascular and Type-2 Diabetes Risk in Obese Subjects.
Obesity
Tacrolimus Exposure in Obese Patients: A Case-Control Study in Kidney Transplantation.
Obesity
The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.
Obesity
The effect of obesity on the ratio of type 3 17beta-hydroxysteroid dehydrogenase mRNA to cytochrome P450 aromatase mRNA in subcutaneous abdominal and intra-abdominal adipose tissue of women.
Obesity
The effect of obesity, macronutrients, fasting and nutritional status on drug-metabolizing cytochrome P450s: a systematic review of current evidence on human studies.
Obesity
The Influence of Obesity on the Pharmacokinetics of Dioxin in Mice: An Assessment Using Classical and PBPK Modeling.
Obesity
The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases.
Obesity
The role of oestrogen in the pathogenesis of obesity, type 2 diabetes, breast cancer and prostate disease.
Obesity
Transcriptome Analysis of Testis from HFD-Induced Obese Rats (Rattus norvigicus) Indicated Predisposition for Male Infertility.
Obesity
Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease.
Obesity
Vitamin D pathway-related gene polymorphisms and their association with metabolic diseases: A literature review.
Obesity
Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models.
Obesity
[Perfusion and metabolism of liver and splanchnic nerve area under sevoflurane anesthesia]
Obesity, Abdominal
Association of cytochrome P450 1B1 gene polymorphisms and environmental biomarkers with hypertension in Slovak midlife women.
Obesity, Abdominal
Relationship Between Amounts of Daily Cigarette Consumption and Abdominal Obesity Moderated by CYP2A6 Genotypes in Chinese Male Current Smokers.
Obesity, Abdominal
The CYP19 gene and associations with androgens and abdominal obesity in premenopausal women.
Obesity, Morbid
CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.
Obesity, Morbid
Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity.
Obesity, Morbid
Short- and medium-term impact of bariatric surgery on the activities of CYP2D6, CYP3A4, CYP2C9, and CYP1A2 in morbid obesity.
Obstetric Labor, Premature
Nifedipine Pharmacokinetics Are Influenced by CYP3A5 Genotype When Used as a Preterm Labor Tocolytic.
Occupational Diseases
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
Occupational Diseases
Decreased Cyp2E1 mRNA expression in human leucocytes in patients with fibrotic and inflammatory lung diseases.
Ocular Hypertension
Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma.
Ocular Hypertension
Survey of familial glaucoma shows a high incidence of cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) mutations in non-consanguineous congenital forms in a Spanish population.
Oligodendroglioma
Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target.
Oligospermia
[Genetic genes associated with oligospermia, asthenospermia and teratospermia: Advances in studies].
Onchocerciasis
Genetic polymorphisms in MDR1, CYP3A4 and CYP3A5 genes in a Ghanaian population: a plausible explanation for altered metabolism of ivermectin in humans?
Opioid-Induced Constipation
Simulation and Prediction of the Drug-Drug Interaction Potential of Naloxegol by Physiologically Based Pharmacokinetic Modeling.
Opisthorchiasis
Andrographolide Ameliorates Beta-Naphthoflavone-Induced CYP1A Enzyme Activity and Lipid Peroxidation in Hamsters with Acute Opisthorchiasis.
Opisthorchiasis
Induction of cytochrome P450 2A6 expression in humans by the carcinogenic parasite infection, opisthorchiasis viverrini.
Opisthorchiasis
Infection with carcinogenic helminth parasites and its production of metabolites induces the formation of DNA-adducts.
Opportunistic Infections
Interactions between recreational drugs and antiretroviral agents.
Optic Atrophy
Biallelic mutations in the ferredoxin reductase gene cause novel mitochondriopathy with optic atrophy.
Oral Submucous Fibrosis
Association of CYP1A1, GSTM1, and GSTT1 gene polymorphism with risk of oral submucous fibrosis in a section of North Indian population.
Oral Submucous Fibrosis
CYP1AI and CYP2E1 gene polymorphisms may increase susceptibility to Oral Submucous Fibrosis among betel quid chewers of Eastern India.
Oral Submucous Fibrosis
Novel genetic biomarkers for susceptibility to oral submucous fibrosis: cytochrome P450 3A.
Oral Submucous Fibrosis
Roles of CYP1A1 and CYP2E1 Gene Polymorphisms in Oral Submucous Fibrosis.
Oral Submucous Fibrosis
[Expression of cytochrome P450 related genes in oral submucous fibrosis tissue].
Oral Submucous Fibrosis
[Expression of loricrin and cytochrome P450 3A5 in oral submucous fibrosis and their significance]
Oral Ulcer
Respiratory, cardiovascular and other physiological consequences of smoking cessation.
Oropharyngeal Neoplasms
Oral and oropharyngeal cancer, aryl hydrocarbon hydroxylase inducibility and smoking. A follow-up study.
Osteoarthritis
PIM1, CYP1B1, and HSPA2 Targeted by Quercetin Play Important Roles in Osteoarthritis Treatment by Achyranthes bidentata.
Osteomalacia
Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D(3) through CYP3A4 induction in vitro and in vivo: Implications for drug-induced osteomalacia.
Osteomalacia
Osteomalacia in an HIV-infected man receiving rifabutin, a cytochrome P450 enzyme inducer: a case report.
Osteomyelitis
[The state of the microsomal oxidative system in the liver of rats with acute osteomyelitis of the mandible]
Osteonecrosis
A SNP in CYP2C8 is not associated with the development of bisphosphonate-related osteonecrosis of the jaw in men with castrate-resistant prostate cancer.
Osteonecrosis
Association between CYP2C8 (rs1934951) Polymorphism and Bisphosphonate-Related Osteonecrosis of the Jaws in Patients on Bisphosphonate Therapy: A Meta-Analysis.
Osteonecrosis
Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis.
Osteonecrosis
CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma.
Osteonecrosis
Low hepatic cytochrome P450 3A activity is a risk for corticosteroid-induced osteonecrosis.
Osteonecrosis
Low levels of steroid-metabolizing hepatic enzyme (cytochrome P450 3A) activity may elevate responsiveness to steroids and may increase risk of steroid-induced osteonecrosis even with low glucocorticoid dose.
Osteonecrosis
The effects of P-gp and CYP450 modulated by rifampicin on the steroid-induced osteonecrosis of the femoral head.
Osteoporosis
A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome.
Osteoporosis
A polymorphic CYP19 TTTA repeat influences aromatase activity and estrogen levels in elderly men: effects on bone metabolism.
Osteoporosis
Association of CYP1A1 and CYP1B1 polymorphisms with bone mineral density variations in postmenopausal Mexican-Mestizo women.
Osteoporosis
Association of serum sex steroid levels and bone mineral density with CYP17 and CYP19 gene polymorphisms in postmenopausal women in Turkey.
Osteoporosis
Contribution of genetic variations in estradiol biosynthesis and metabolism enzymes to osteoporosis.
Osteoporosis
Elimination of major side effects due to ROS of therapeuticals through biotransformation control of the 57 cytochromes P450 isoenzymes.
Osteoporosis
Functional Analyses of Four CYP1A1 Missense Mutations Present in Patients with Atypical Femoral Fractures.
Osteoporosis
Genome-wide association with bone mass and geometry in the Framingham Heart Study.
Osteoporosis
In silico identification and screening of CYP24A1 inhibitors: 3D QSAR pharmacophore mapping and molecular dynamics analysis.
Osteoporosis
Incidence of Mutations in the ALPL, GGPS1, and CYP1A1 Genes in Patients With Atypical Femoral Fractures.
Osteoporosis
Multilocus analysis of estrogen-related genes in Spanish postmenopausal women suggests an interactive role of ESR1, ESR2 and NRIP1 genes in the pathogenesis of osteoporosis.
Osteoporosis
Polymorphisms in the CYP19 and AR genes--relation to bone mass and longitudinal bone changes in postmenopausal women with or without hormone replacement therapy: The Danish Osteoporosis Prevention Study.
Osteoporosis
Preventing Cushing: Iatrogenic Cushing Syndrome due to Ritonavir-Fluticasone Interaction.
Osteoporosis
The role of estrogen receptor-alpha gene TA polymorphism and aromatase gene TTTA polymorphism on peak bone mass attainment in males: is there an additive negative effect of certain allele combinations?
Osteoporosis
The Val432Leu polymorphism of the CYP1B1 gene is associated with differences in estrogen metabolism and bone density.
Osteosarcoma
Analysis of Drug Metabolizing Gene Panel in Osteosarcoma Patients Identifies Association Between Variants in SULT1E1, CYP2B6 and CYP4F8 and Methotrexate Levels and Toxicities.
Osteosarcoma
Cas9 Protein Triggers Differential Expression of Inherent Genes Especially NGFR Expression in 293T Cells.
Osteosarcoma
Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma.
Osteosarcoma
Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines.
Osteosarcoma
Expression of the aryl hydrocarbon receptor pathway and cyclooxygenase-2 in dog tumors.
Osteosarcoma
Identification of co-expression modules and pathways correlated with osteosarcoma and its metastasis.
Osteosarcoma
Identification of genetic variants in pharmacokinetic genes associated with Ewing Sarcoma treatment outcome.
Osteosarcoma
Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Ototoxicity
CYP Genotypes Are Associated with Toxicity and Survival in Osteosarcoma Patients.
Ovarian Cysts
Hypothalamic-pituitary-ovarian axis during infancy, early and late prepuberty in an aromatase-deficient girl who is a compound heterocygote for two new point mutations of the CYP19 gene.
Ovarian Diseases
FSH receptor, KL1/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis.
Ovarian Hyperstimulation Syndrome
Modulation of steroidogenesis by vitamin D3 in granulosa cells of the mouse model of polycystic ovarian syndrome.
Ovarian Neoplasms
Analysis of Over 10,000 Cases Finds No Association between Previously-Reported Candidate Polymorphisms and Ovarian Cancer Outcome.
Ovarian Neoplasms
Biomarkers of sensitivity to potent and selective antitumor 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F203) in ovarian cancer.
Ovarian Neoplasms
Case-control study of ovarian cancer and polymorphisms in genes involved in catecholestrogen formation and metabolism.
Ovarian Neoplasms
CYP1B1 determines susceptibility to low doses of 7,12-dimethylbenz[a]anthracene-induced ovarian cancers in mice: correlation of CYP1B1-mediated DNA adducts with carcinogenicity.
Ovarian Neoplasms
CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKC? activation and phosphorylation of XIAP.
Ovarian Neoplasms
Cytochrome P1B1 (CYP1B1) polymorphisms and ovarian cancer risk: a meta-analysis.
Ovarian Neoplasms
Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and ovarian cancer risk: a meta-analysis.
Ovarian Neoplasms
Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer.
Ovarian Neoplasms
Effect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-label Studies.
Ovarian Neoplasms
Estradiol 17? and Its Metabolites Stimulate Cell Proliferation and Antagonize Ascorbic Acid-Suppressed Cell Proliferation in Human Ovarian Cancer Cells.
Ovarian Neoplasms
Estradiol enhances and estriol inhibits the expression of CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in a mouse ovarian cancer cell line.
Ovarian Neoplasms
Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells.
Ovarian Neoplasms
Genetic variation in ABCB1 influences paclitaxel pharmacokinetics in Japanese patients with ovarian cancer.
Ovarian Neoplasms
Interaction between CYP1A1 polymorphic variants and dietary exposures influencing ovarian cancer risk.
Ovarian Neoplasms
Knockdown of CYP24A1 Aggravates 1?,25(OH)2D3-Inhibited Migration and Invasion of Mouse Ovarian Epithelial Cells by Suppressing EMT.
Ovarian Neoplasms
Metabolic behavior prediction of pazopanib by cytochrome P450 (CYP) 3A4 by molecular docking.
Ovarian Neoplasms
Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis.
Ovarian Neoplasms
Oxidative Stress and Antioxidant Defense in Endometriosis and Its Malignant Transformation.
Ovarian Neoplasms
Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer.
Ovarian Neoplasms
Pharmacogenetic studies of Paclitaxel in the treatment of ovarian cancer.
Ovarian Neoplasms
Pharmacokinetics of paclitaxel in ovarian cancer patients and genetic polymorphisms of CYP2C8, CYP3A4, and MDR1.
Ovarian Neoplasms
Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1.
Ovarian Neoplasms
Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.
Ovarian Neoplasms
Progestins inhibit calcitriol-induced CYP24A1 and synergistically inhibit ovarian cancer cell viability: An opportunity for chemoprevention.
Ovarian Neoplasms
Refinement of an ovarian cancer tumour suppressor gene locus on chromosome arm 22q and mutation analysis of CYP2D6, SREBP2 and NAGA.
Ovarian Neoplasms
Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4'-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells.
Ovarian Neoplasms
The CYP1A1 Ile462Val polymorphism and platinum resistance of epithelial ovarian neoplasms.
Ovarian Neoplasms
The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity.
Ovarian Neoplasms
The ovarian carcinoma risk with the polymorphisms of CYP1B1 come from the positive selection.
Ovarian Neoplasms
The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKC? signaling.
Ovarian Neoplasms
Validation of PCR-RFLP techniques for the evaluation of codon 72 of p53 and CYP1A1 gene's polymorphisms in relation with ovarian cancer in a Romanian population.
Ovarian Neoplasms
Whole genome expression profiling of blood cells in ovarian cancer patients -prognostic impact of the CYP1B1, MTSS1, NCALD, and NOP14.
Ovarian Neoplasms
[CYP2E1 gene polymorphism and ovarian cancer risk in the Yakut population].
Ovarian Neoplasms
[Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitro].
Overweight
Cephalic phase insulin secretion in relation to food presentation in normal and overweight subjects.
Overweight
Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women.
Overweight
Short- and medium-term impact of bariatric surgery on the activities of CYP2D6, CYP3A4, CYP2C9, and CYP1A2 in morbid obesity.
Overweight
[Variability in the frequency of TCR-mutant lymphocytes associated with gene polymorphisms in women living in radiation-polluted areas].
Ovotesticular Disorders of Sex Development
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
Pancreatic Diseases
Differences in immunohistochemical expression of xenobiotic-metabolizing enzymes between normal pancreas, chronic pancreatitis and pancreatic cancer.
Pancreatic Neoplasms
Contribution of environment and genetics to pancreatic cancer susceptibility.
Pancreatic Neoplasms
CYP1B1 gene polymorphism modifies pancreatic cancer risk but not survival.
Pancreatic Neoplasms
CYP1B1 Polymorphisms and K-ras Mutations in Patients with Pancreatic Ductal Adenocarcinoma.
Pancreatic Neoplasms
Differences in immunohistochemical expression of xenobiotic-metabolizing enzymes between normal pancreas, chronic pancreatitis and pancreatic cancer.
Pancreatic Neoplasms
Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy and are safe and efficacious: data from two clinical trials in pancreatic cancer.
Pancreatic Neoplasms
Genetic variants in vitamin d pathway genes and risk of pancreas cancer; results from a population-based case-control study in ontario, Canada.
Pancreatic Neoplasms
Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer.
Pancreatic Neoplasms
Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma.
Pancreatic Neoplasms
Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.
Pancreatic Neoplasms
Smoking-gene interaction and disease development: relevance to pancreatic cancer and atherosclerosis.
Pancreatic Neoplasms
Targeting the CYP2B 1/cyclophosphamide suicide system to fibroblast growth factor receptors results in a potent antitumoral response in pancreatic cancer models.
Pancreatic Neoplasms
The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748.
Pancreatitis
A Young Woman with Recurrent Gestational Hypercalcemia and Acute Pancreatitis Due to CYP24A1 Deficiency.
Pancreatitis
Alcohol-metabolizing enzyme gene polymorphisms and alcohol chronic pancreatitis among Polish individuals.
Pancreatitis
Genetic polymorphism of CYP2E1 and digestive tract alcohol damage among Polish individuals.
Pancreatitis
Genotypes of alcohol-metabolizing enzymes in relation to alcoholic chronic pancreatitis in Japan.
Pancreatitis
Genotypes of Alcohol-Metabolizing Enzymes in Relation to Alcoholic Chronic Pancreatitis in Japan.
Pancreatitis
Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics.
Pancreatitis
Statins and their role in acute pancreatitis: Case report and literature review.
Pancreatitis
[Change in the rat liver microsomal monooxygenase system upon induction with phenobarbital in acute pancreatitis]
Pancreatitis
[Changes in the microsomal monooxygenase system of the rat liver in acute pancreatitis and during induction by Aroclor 1254]
Pancreatitis
[Protective effect of fructus gardeniae on pancreatic subcellular organs of the acute pancreatitis in rats]
Pancreatitis
[Remote effects of Aroclor 1254 on the rat liver microsomal monooxygenase activity in acute pancreatitis]
Pancreatitis
[Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs].
Pancreatitis, Alcoholic
Association between genetic variants in CYP2E1 and CTRC genes and susceptibility to alcoholic pancreatitis: A systematic review and meta-analysis.
Pancreatitis, Alcoholic
Genetic polymorphism in cytochrome P450 2E1 and alcoholic pancreatitis sus-ceptibility: a meta-analysis.
Pancreatitis, Alcoholic
Study of polymorphisms in the CYP2E1 gene in patients with alcoholic pancreatitis.
Pancreatitis, Chronic
'Not knowing something is normally a milestone on the way to knowledge'. An interview with Joan M. Braganza, DSc, FRCP, FRCPath, Reader Emeritus, University of Manchester, UK.
Pancreatitis, Chronic
Abnormal drug metabolism in chronic pancreatitis. Treatment with antioxidants.
Pancreatitis, Chronic
Alcohol-metabolizing enzyme gene polymorphisms and alcohol chronic pancreatitis among Polish individuals.
Pancreatitis, Chronic
Antioxidants, enzyme induction, and chronic pancreatitis: a reappraisal following studies in patients on anticonvulsants.
Pancreatitis, Chronic
Differences in immunohistochemical expression of xenobiotic-metabolizing enzymes between normal pancreas, chronic pancreatitis and pancreatic cancer.
Pancreatitis, Chronic
Involvement of free radicals in the pathophysiology of chronic pancreatitis: potential of treatment with antioxidant and scavenger substances.
Pancreatitis, Chronic
Micronutrient antioxidant status in tropical compared with temperate-zone chronic pancreatitis.
Pancreatitis, Chronic
Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.
Pancreatitis, Chronic
Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics.
Pancreatitis, Chronic
Selenium deficiency and chronic pancreatitis: disease mechanism and potential for therapy.
Pancreatitis, Chronic
Toward an animal model of chronic pancreatitis. Pancreatobiliary secretion in hamsters on long-term treatment with chemical inducers of cytochromes P450.
Pancreatitis, Chronic
Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis.
Pancreatitis, Chronic
Xenobiotic metabolism, oxidant stress and chronic pancreatitis. Focus on glutathione.
Pancreatitis, Chronic
[Polymorphism of ethanol metabolism genes in alcoholic chronic pancreatitis].
Pantothenate Kinase-Associated Neurodegeneration
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Papilloma
Concomitance of oncogenic HPV types, CHEK2 gene mutations, and CYP1B1 gene polymorphism as an increased risk factor for malignancy.
Papilloma
Differential induction of Cyp1a1, Cyp1b1, Ahd4, and Nmo1 in murine skin tumors and adjacent normal epidermis by ligands of the aryl hydrocarbon receptor.
Papilloma
Effects of benzo[a]pyrene, aromatic amines, and a combination of both on CYP1A1 activities in RT-4 human bladder papilloma cells.
Papillomavirus Infections
CYP1B1 C4326G polymorphism and susceptibility to cervical cancer in Chinese Han women.
Papillomavirus Infections
Functional variants in CYP1A1 and GSTM1 are associated with clearance of cervical HPV infection.
Papillomavirus Infections
Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: associations with tumor progression, age and human papillomavirus infection.
Papillomavirus Infections
Polymorphisms and haplotypes of TLR4, TLR9 and CYP1A1 genes possibly interfere with high-risk human papillomavirus infection and cervical cancer susceptibility in Jharkhand, India.
Paralysis
A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism.
Paralysis
Anti-clastogenic effect of magnolol-containing Hange-koboku-to, Dai-joki-to, Goshaku-san, and Magnoliae Cortex on benzo(a)pyrene-induced clastogenicity in mice.
Paralysis
Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo.
Paralysis
Effect of novel anti-inflammatory ethanolamine derivatives with antioxidant properties on drug metabolising enzymes.
Paralysis
In vivo modulation of the rat cytochrome P450 1A1 by double-stranded phosphorothioate oligodeoxynucleotides.
Paralysis
Inhibitory effect of magnolol on Trp-P-2-induced DNA damage in various organs in mice.
Paralysis
Intensity of Schistosoma mansoni infection determines alterations in hepatic drug metabolism.
Paralysis
Moricizine, an antiarrhythmic agent, as a potent inhibitor of hepatic microsomal CYP1A.
Paralysis
Neonatal toxicity in mice associated with the Ahb allele following transplacental exposure to 3-methylcholanthrene.
Paralysis
The Ah regulatory gene product. Survey of nineteen polycyclic aromatic compounds' and fifteen benzo[a]pyrene metabolites' capacity to bind to the cytosolic receptor.
Paralysis
The murine aromatic hydrocarbon responsiveness locus: a comparison of receptor levels and several inducible enzyme activities among recombinant inbred lines.
Paraplegia
A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform.
Paraplegia
An atypical case of SPG56/CYP2U1-related spastic paraplegia presenting with delayed myelination.
Paraplegia
Chinese patient with cerebrotendinous xanthomatosis confirmed by genetic testing: A case report and literature review.
Paraplegia
Plasma oxysterols: biomarkers for diagnosis and treatment in spastic paraplegia type 5.
Parasitemia
The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment.
Parasitic Diseases
A non-hepatotropic parasite infection increases mortality in the acetaminophen-induced acute liver failure murine model: possible roles for IL-5 and IL-6.
Parasitic Diseases
Incidence of experimental fascioliasis on the activity of drug-metabolizing enzymes in lamb liver.
Parasitic Diseases
Induction of cytochrome P450 2A6 expression in humans by the carcinogenic parasite infection, opisthorchiasis viverrini.
Parathyroid Neoplasms
A Possible Link Between Parathyroid Hormone Secretion and Local Regulation of GABA in Human Parathyroid Adenomas.
Parathyroid Neoplasms
An Excess of CYP24A1, Lack of CaSR, and a Novel lncRNA Near the PTH Gene Characterize an Ectopic PTH-Producing Tumor.
Paresis
A synopsis on different homologous series of fomocaine derivatives. In vitro interactions with the cytochrome P450 system, toxicity, and local anaesthetic effects in rats--Part 1.
Parkinson Disease
ADORA2A rs5760423 and CYP1A2 rs762551 Polymorphisms as Risk Factors for Parkinson's Disease.
Parkinson Disease
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.
Parkinson Disease
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: partial protection against striato-nigral dopamine depletion in C57BL/6J mice by cigarette smoke exposure and by beta-naphthoflavone-pretreatment.
Parkinson Disease
A novel cytochrome P-450IID6 mutant gene associated with Parkinson's disease.
Parkinson Disease
Absence of effect of seven functional mutations in the CYP2D6 gene in Parkinson's disease.
Parkinson Disease
Acetaminophen metabolism by cytochrome P450 monooxygenases in Parkinson's disease.
Parkinson Disease
An attempt to replicate interaction between coffee and CYP1A2 gene in connection to Parkinson's disease.
Parkinson Disease
ApoE and CYP2D6 polymorphism with and without parkinsonism-dementia complex in the people of Chamorro, guam.
Parkinson Disease
APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson's disease in a Japanese population.
Parkinson Disease
Association between the oxidative polymorphism and early onset of Parkinson's disease.
Parkinson Disease
Association of CYP2D microsatellite polymorphism with Lewy body variant of Alzheimer's disease.
Parkinson Disease
Association of polymorphism in cytochrome P450 2D6 and N-acetyltransferase-2 with Parkinson's disease.
Parkinson Disease
Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease.
Parkinson Disease
Characterization and localization of cytochrome P450 mediated metabolism of MPTP to nor-MPTP in mouse brain: relevance to Parkinson's disease.
Parkinson Disease
Co-localization of P450 enzymes in the rat substantia nigra with tyrosine hydroxylase.
Parkinson Disease
Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson's disease.
Parkinson Disease
CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes.
Parkinson Disease
CYP2D6 gene polymorphism as a probable risk factor for Alzheimer's disease and Parkinson's disease with dementia.
Parkinson Disease
CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy Bodies or Alzheimer's disease.
Parkinson Disease
CYP2D6*4 allele polymorphism increases the risk of Parkinson's disease: evidence from meta-analysis.
Parkinson Disease
CYP2D6-debrisoquine hydroxylase gene polymorphism in multiple system atrophy.
Parkinson Disease
Cytochrome P450 2D6 and Parkinson's Disease: Polymorphism, Metabolic Role, Risk and Protection.
Parkinson Disease
Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells.
Parkinson Disease
Cytochrome P450 2E1 gene polymorphisms/haplotypes and Parkinson's disease in a Swedish population.
Parkinson Disease
Cytochrome P450 2E1 in the substantia nigra: Relevance for dopaminergic neurotransmission and free radical production.
Parkinson Disease
Cytochrome P450 and Parkinson's disease. Poor parahydroxylation of phenytoin.
Parkinson Disease
Cytochrome P450 and Parkinson's disease: protective role of neuronal CYP 2E1 from MPTP toxicity.
Parkinson Disease
Cytochrome P450 isozymes catalyzing 4-hydroxylation of parkinsonism-related compound 1,2,3,4-tetrahydroisoquinoline in rat liver microsomes.
Parkinson Disease
Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration.
Parkinson Disease
Cytochrome P450-dependent metabolism of l-deprenyl in monkey (Cercopithecus aethiops) and C57BL/6 mouse brain microsomal preparations.
Parkinson Disease
Debrisoquine 4-hydroxylase (CYP2D6) genetic polymorphisms and susceptibility to schizophrenia in Chinese patients from Taiwan.
Parkinson Disease
Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease.
Parkinson Disease
Debrisoquine hydroxylase gene polymorphism in familial Parkinson's disease.
Parkinson Disease
Differential expression of cytochrome P450 enzymes in cultured and intact foetal rat ventral mesencephalon.
Parkinson Disease
Effect of reboxetine on major depressive disorder in breast cancer patients: an open-label study.
Parkinson Disease
Evaluating environmental impact of STP effluents on receiving water in Beijing by the joint use of chemical analysis and biomonitoring.
Parkinson Disease
Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's disease.
Parkinson Disease
Gene-environment interaction in parkinson's disease. The case of CYP2D6 gene polymorphism.
Parkinson Disease
Gene-Environment Interaction in Parkinson's Disease: Coffee, ADORA2A, and CYP1A2.
Parkinson Disease
Genetic and environmental risk factors for Parkinson's disease in a Chinese population.
Parkinson Disease
Genetic polymorphism and Parkinson's disease in Taiwan: study of debrisoquine 4-hydroxylase (CYP2D6).
Parkinson Disease
Genetic polymorphism of cytochrome P450 2D6 in idiopathic Parkinson disease and diffuse Lewy body disease.
Parkinson Disease
Genetic polymorphism of the CYP2E1 gene and susceptibility to Parkinson's disease in Taiwanese.
Parkinson Disease
Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands.
Parkinson Disease
Genetic variability of the CYP 2D6 gene is not a risk factor for sporadic Parkinson's disease.
Parkinson Disease
Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1.
Parkinson Disease
Interaction between caffeine and polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2) on Parkinson's disease risk.
Parkinson Disease
Interaction between GSTM1-null and CYP2D6-deficient alleles in the pathogenesis of Parkinson's disease.
Parkinson Disease
Involvement of cytochrome P450 2E1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.
Parkinson Disease
Is there a genetic susceptibility locus for Parkinson's disease on chromosome 22q13?
Parkinson Disease
l-Deprenyl metabolism by the cytochrome P450 system in monkey (Cercopithecus aethiops) liver microsomes.
Parkinson Disease
Lack of association between CYP1A1 polymorphism and Parkinson's disease in a Chinese population.
Parkinson Disease
Lack of association between cytochrome P450 2E1 gene polymorphisms and Parkinson's disease in a Chinese population.
Parkinson Disease
Lack of relation between genetic polymorphism of cytochrome P-450IID6 and sporadic idiopathic Parkinson's disease.
Parkinson Disease
Loss of aromatase cytochrome P450 function as a risk factor for Parkinson's disease?
Parkinson Disease
Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson's disease.
Parkinson Disease
Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.
Parkinson Disease
MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation.
Parkinson Disease
MPTP-induced model of Parkinson's disease in cytochrome P450 2E1knockout mice.
Parkinson Disease
Mutation frequencies of the cytochrome CYP2D6 gene in Parkinson disease patients and in families.
Parkinson Disease
Neurogenetic correlates of Parkinson's disease: apolipoprotein-E and cytochrome P450 2D6 genetic polymorphism.
Parkinson Disease
No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian population.
Parkinson Disease
P450 and heme oxygenase enzymes in the basal ganglia and their roles in Parkinson's disease.
Parkinson Disease
Parkinson's disease and CYP2D6 polymorphism in Asian populations: A meta-analysis.
Parkinson Disease
Parkinson's disease, but not Alzheimer's disease, Lewy body variant associated with mutant alleles at cytochrome P450 gene.
Parkinson Disease
Phenytoin parahydroxylation is not impaired in patients with young-onset Parkinson's disease.
Parkinson Disease
Polymorphisms of catechol-0-methyltransferase (COMT), monoamine oxidase B (MAOB), N-acetyltransferase 2 (NAT2) and cytochrome P450 2D6 (CYP2D6) gene in patients with early onset of Parkinson's disease.
Parkinson Disease
Proteomics analyses for the global proteins in the brain tissues of different human prion diseases.
Parkinson Disease
Rarity of debrisoquine hydroxylase gene polymorphism in Chinese patients with Parkinson's disease.
Parkinson Disease
Recombinant cytochrome P450 2D18 metabolism of dopamine and arachidonic acid.
Parkinson Disease
Response to Hill-Burns et al. letter: An attempt to replicate interaction between coffee and CYP1A2 gene in connection to Parkinson's disease.
Parkinson Disease
Resveratrol potentiates cytochrome P450 2d22-mediated neuroprotection in maneb- and paraquat-induced parkinsonism in the mouse.
Parkinson Disease
Selective localisation of P450 enzymes and NADPH-P450 oxidoreductase in rat basal ganglia using anti-peptide antisera.
Parkinson Disease
SSRI-induced extrapyramidal side-effects and akathisia: implications for treatment.
Parkinson Disease
The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: a case-control study and meta-analysis.
Parkinson Disease
The CYP2D6B allele is not overrepresented in a population of German patients with idiopathic Parkinson's disease.
Parkinson Disease
The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.
Parkinson Disease
The HhaI polymorphism in the CYP2D6 gene is not associated with Parkinson's disease in a Caucasian population.
Parkinson Disease
The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients.
Parkinson Disease
Unveiling the Role of Cytochrome P450 (2E1) in Human Brain Specifically in Parkinson's Disease - Literature Review.
Parkinson Disease
Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease.
Parkinson Disease
[Genetic polymorphisms of cytochrome P450 1A1 and susceptibility of early-onset Parkinson's disease]
Parkinson Disease
[Polymorphisms in the genes of cytochrome oxidase P450 2D6 (CYP2D6), paraoxonase 1 (PON1) and apolipoprotein E (APOE) as risk factors for Parkinson's disease]
Parkinson Disease
[Prevalence of CYPD6 mutations in sporadic Parkinson's disease: case-control study]
Parkinson Disease
[Role of gene polymorphism of catechol-O-methyltransferase (COMT), monoamine oxidase B (MAOB), cytochrome P450 2D6 (CYP2D6) and N-acetyltransferase 2 (NAT2) in pathogenesis of Parkinson's disease]
Parkinsonian Disorders
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a substrate of cytochrome P450 2D6: allosteric effects of NADPH-cytochrome P450 reductase.
Parkinsonian Disorders
Acute effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in a model of rat designated a poor metabolizer of debrisoquine.
Parkinsonian Disorders
Association of tardive dyskinesia with variation in CYP2D6: Is there a role for active metabolites?
Parkinsonian Disorders
Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
Parkinsonian Disorders
Cytochrome P450 2D6 and Parkinson's Disease: Polymorphism, Metabolic Role, Risk and Protection.
Parkinsonian Disorders
Cytochrome p450 phenotyping/genotyping in patients receiving antipsychotics: useful aid to prescribing?
Parkinsonian Disorders
Cytochrome P450 polymorphisms and response to antipsychotic therapy.
Parkinsonian Disorders
Involvement of Peroxiredoxin-3, Thioredoxin-2, and Protein Deglycase-1 in Cypermethrin-Induced Parkinsonism.
Parkinsonian Disorders
Maintenance therapy with zuclopenthixol decanoate: associations between plasma concentrations, neurological side effects and CYP2D6 genotype.
Parkinsonian Disorders
Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson's disease.
Parkinsonian Disorders
Mitochondrial NADH dehydrogenase and CYP2D6 genotypes in Lewy-body parkinsonism.
Parkinsonian Disorders
Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II.
Parkinsonian Disorders
Resveratrol potentiates cytochrome P450 2d22-mediated neuroprotection in maneb- and paraquat-induced parkinsonism in the mouse.
Parkinsonian Disorders
Resveratrol regulates Nrf2-mediated expression of antioxidant and xenobiotic metabolizing enzymes in pesticides-induced Parkinsonism.
Parkinsonian Disorders
Sex differences in autophagy-mediated diseases: toward precision medicine.
Parkinsonian Disorders
The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation.
Parkinsonian Disorders
The CYP2D6B allele is not overrepresented in a population of German patients with idiopathic Parkinson's disease.
Pediatric Obesity
Potential role of aryl hydrocarbon receptor signaling in childhood obesity.
Pediatric Obesity
The impacts of the interaction of genetic variation, CYP11?2 and NEDD4L, with sodium intake on pediatric obesity with gender difference: a 3-year panel study.
Peptic Ulcer
Allele variants of the cytochrome P450 2C9 genotype in white subjects from The Netherlands with serious gastroduodenal ulcers attributable to the use of NSAIDs.
Peptic Ulcer
CYP3A and CYP2C19 activity in urine in relation to CYP3A4, CYP3A5, and CYP2C19 polymorphisms in Russian peptic ulcer patients taking omeprazole.
Peptic Ulcer
Effects of Genetic Polymorphisms of Cytochrome P450 Enzymes and MDR1 Transporter on Pantoprazole Metabolism and Helicobacter pylori Eradication.
Peptic Ulcer
Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection.
Peptic Ulcer
Impact of body size on first-line Helicobacter pylori eradication success using vonoprazan and amoxicillin dual therapy.
Peptic Ulcer
The frequency of CYP2C19 genetic polymorphisms in Russian patients with peptic ulcers treated with proton pump inhibitors.
Pericardial Effusion
A Possible Drug-Drug Interaction Between Eliquis and Amiodarone Resulting in Hemopericardium.
Pericardial Effusion
Fluoranthene, but not benzo[a]pyrene, interacts with hypoxia resulting in pericardial effusion and lordosis in developing zebrafish.
Periodontitis
Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status.
Periodontitis
Polymorphisms in genes coding for enzymes metabolizing smoking-derived substances and the risk of periodontitis.
Periodontitis
Protective roles of FICZ and aryl hydrocarbon receptor axis on alveolar bone loss and inflammation in experimental periodontitis.
Peripheral Arterial Disease
Acetylation phenotype and cytochrome P450IA2 phenotype are unlikely to be associated with peripheral arterial disease.
Peripheral Arterial Disease
Patients carrying CYP2C19 loss of function alleles have a reduced response to clopidogrel therapy and a greater risk of in-stent restenosis after endovascular treatment of lower extremity peripheral arterial disease.
Peripheral Nerve Injuries
[The role of CYP2E1 in the protection of garlic oil's from n-hexane-induced neurotoxicity].
Peripheral Nervous System Diseases
Chinese patient with cerebrotendinous xanthomatosis confirmed by genetic testing: A case report and literature review.
Peripheral Nervous System Diseases
Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer status.
Peripheral Nervous System Diseases
Differential interactions of Cytochrome P450 3A5 and 3A4 with chemotherapeutic agent- vincristine: A comparative molecular dynamics study.
Peripheral Nervous System Diseases
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Peripheral Nervous System Diseases
Drug interaction between itraconazole and bortezomib: exacerbation of peripheral neuropathy and thrombocytopenia induced by bortezomib.
Peripheral Nervous System Diseases
Genotypes of CYP2C8 and FGD4 and their association with peripheral neuropathy or early dose reduction in paclitaxel-treated breast cancer patients.
Peripheral Nervous System Diseases
Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: a pilot study.
Peripheral Nervous System Diseases
Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia.
Peripheral Nervous System Diseases
Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain.
Peripheral Nervous System Diseases
Severe Neuropathic Pain With Concomitant Administration of Vincristine and Posaconazole.
Peripheral Nervous System Diseases
Severe Vincristine-induced Neuropathic Pain in a CYP3A5 Nonexpressor With Reduced CYP3A4/5 Activity: Case Study.
Peripheral Nervous System Diseases
[Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs].
Peritonitis
Corrigendum to "Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6" [Cell. Immunol. 349 (2020) 104047].
Peritonitis
Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6.
Peritonitis
Hepatic oxygen consumption and cytochrome P450 activity in experimental faecal peritonitis.
Pharyngeal Neoplasms
CYP1A1, mEH, and GSTM1 Polymophisms and Risk of Oral and Pharyngeal Cancer: A Spanish Case-Control Study.
Pharyngeal Neoplasms
Cytochrome p450 metabolism of betel quid-derived compounds: implications for the development of prevention strategies for oral and pharyngeal cancers.
Pharyngeal Neoplasms
Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to head-and-neck squamous-cell carcinoma.
Pharyngeal Neoplasms
Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review.
Pharyngeal Neoplasms
The association of the CYP1A1 Ile462Val polymorphism with head and neck cancer risk: evidence based on a cumulative meta-analysis.
Pheochromocytoma
Overexpression of CYP2D6 attenuates the toxicity of MPP+ in actively dividing and differentiated PC12 cells.
Pheochromocytoma
Pheochromocytoma and sub-clinical Cushing's syndrome during pregnancy: diagnosis, medical pre-treatment and cure by laparoscopic unilateral adrenalectomy.
Phimosis
Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter.
phospholipase a2 deficiency
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Photophobia
Phototoxicity of plant secondary metabolites: insect and mammalian perspectives.
Photosensitivity Disorders
Inhibition of 6-formylindolo[3,2-b]carbazole metabolism sensitizes keratinocytes to UVA-induced apoptosis: Implications for vemurafenib-induced phototoxicity.
Photosensitivity Disorders
Photosensitizing Furocoumarins: Content in Plant Matrices and Kinetics of Supercritical Carbon Dioxide Extraction.
Photosensitivity Disorders
Studies on the nature of in vitro and in vivo photosensitization reactions by psoralens and porphyrins.
Pituitary Neoplasms
CYP2D6 genetic polymorphisms are associated with susceptibility to pituitary tumors.
Pituitary Neoplasms
Glutathione S-Transferases and Cytochrome P450 Enzyme Expression in Patients with Intracranial Tumors: Preliminary Report of 55 Patients.
Pituitary Neoplasms
GSTM1 and CYP2D6 genotype frequencies in patients with pituitary tumours: effects on P53, ras and gsp.
Pituitary Neoplasms
Multiple structural and functional abnormalities in the p450 aromatase expressing transgenic male mice are ameliorated by a p450 aromatase inhibitor.
Pleural Effusion
Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole.
Pleurisy
CYP1A1, GCLC, AGT, AGTR1 gene-gene interactions in community-acquired pneumonia pulmonary complications.
Pneumoconiosis
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
Pneumonia
A comparison of available and investigational antibiotics for complicated skin infections and treatment-resistant Staphylococcus aureus and enterococcus.
Pneumonia
Association of the ACE, GSTM1, IL-6, NOS3, and CYP1A1 polymorphisms with susceptibility of mycoplasma pneumoniae pneumonia in Chinese children.
Pneumonia
Cooperation of the inducible nitric oxide synthase and cytochrome P450 1A1 in mediating lung inflammation and mutagenicity induced by diesel exhaust particles.
Pneumonia
CYP1A1, GCLC, AGT, AGTR1 gene-gene interactions in community-acquired pneumonia pulmonary complications.
Pneumonia
Cytochrome P450 metabolites of arachidonic acid but not cyclooxygenase-2 metabolites contribute to the pulmonary vascular hyporeactivity in rats with acute Pseudomonas pneumonia.
Pneumonia
Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice.
Pneumonia
Genetic polymorphisms in the cytochromes P-450 (1A1, 2E1), microsomal epoxide hydrolase and glutathione S-transferase M1, T1, and P1 genes, and their relationship with chronic bronchitis and relapsing pneumonia in children.
Pneumonia
Pulmonary cytochrome P-450 2J4 is reduced in a rat model of acute Pseudomonas pneumonia.
Pneumonia
Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene.
Pneumonia
Regulation of pulmonary and hepatic cytochrome P4501A expression in the rat by hyperoxia: implications for hyperoxic lung injury.
Pneumonia
Role of mouse cytochrome P450 enzymes of the CYP2ABFGS subfamilies in the induction of lung inflammation by cigarette smoke exposure.
Pneumonia
[Aryl hydrocarbon receptor modulates airway inflammation in mice with cockroach allergen-induced asthma by regulating Th17/Treg differentiation].
Polycystic Kidney Diseases
Distinct oxylipin alterations in diverse models of cystic kidney diseases.
Polycystic Kidney Diseases
Effect of Cytochrome P450 Metabolites of Arachidonic Acid in Nephrology.
Polycystic Kidney Diseases
Enhancing effects of 2-amino-4,5-diphenylthiazole-induced polycystic kidneys on renal carcinogenesis in rats treated with dimethylnitrosamine.
Polycystic Kidney, Autosomal Dominant
Association of Vitamin D Levels With Kidney Volume in Autosomal Dominant Polycystic Kidney Disease (ADPKD).
Polycystic Kidney, Autosomal Recessive
Distinct oxylipin alterations in diverse models of cystic kidney diseases.
Polycystic Ovary Syndrome
A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese.
Polycystic Ovary Syndrome
Acupuncture does not ameliorate metabolic disturbances in the P450 aromatase inhibitor-induced rat model of polycystic ovary syndrome.
Polycystic Ovary Syndrome
Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome.
Polycystic Ovary Syndrome
Association between CYP19 gene SNP rs2414096 polymorphism and polycystic ovary syndrome in Chinese women.
Polycystic Ovary Syndrome
Association of CYP17A1 gene -34T/C polymorphism with polycystic ovary syndrome in Han Chinese population.
Polycystic Ovary Syndrome
Association of the CYP17 and CYP19 gene polymorphisms in women with polycystic ovary syndrome from Punjab, Pakistan.
Polycystic Ovary Syndrome
Association Study of CYP17 and HSD11B1 in Polycystic Ovary Syndrome Utilizing Comprehensive Gene Coverage.
Polycystic Ovary Syndrome
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Polycystic Ovary Syndrome
Common genetic variation in CYP1B1 is associated with concentrations of T4, FT 3 and FT 4 in the sera of polycystic ovary syndrome patients.
Polycystic Ovary Syndrome
Common polymorphisms in the CYP1A1 and CYP11A1 genes and polycystic ovary syndrome risk: a meta-analysis and meta-regression.
Polycystic Ovary Syndrome
Continuous administration of a P450 aromatase inhibitor induces polycystic ovary syndrome with a metabolic and endocrine phenotype in female rats at adult age.
Polycystic Ovary Syndrome
CYP19 gene expression in subcutaneous adipose tissue is associated with blood pressure in women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
CYP19 gene rs2414096 variant and differential genetic risk of polycystic ovary syndrome: a systematic review and meta-analysis.
Polycystic Ovary Syndrome
CYP19 gene variants affect the assisted reproduction outcome of women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
CYP19 gene: a genetic modifier of polycystic ovary syndrome phenotype.
Polycystic Ovary Syndrome
CYP1A1 Gene Polymorphisms and Polycystic Ovary Syndrome Risk: A Meta-Analysis and Meta-Regression.
Polycystic Ovary Syndrome
CYP1A1 polymorphism in adolescents with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Effects of testosterone on PPAR? and P450arom expression in polycystic ovary syndrome patients and related mechanisms.
Polycystic Ovary Syndrome
Evaluation of the association between the CYP19 Tetranucleotide (TTTA)n polymorphism and polycystic ovarian syndrome(PCOS) in Han Chinese women.
Polycystic Ovary Syndrome
FSH receptor, KL1/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis.
Polycystic Ovary Syndrome
Functional investigation on aromatase in endometrial hyperplasia in polycystic ovary syndrome cases.
Polycystic Ovary Syndrome
Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Granulosa cell aromatase enzyme activity: effects of follicular fluid from patients with polycystic ovary syndrome, using aromatase conversion and [11C]vorozole-binding assays.
Polycystic Ovary Syndrome
Impact of rs2414096 polymorphism of CYP19 gene on susceptibility of polycystic ovary syndrome and hyperandrogenism in Kashmiri women.
Polycystic Ovary Syndrome
Insulin-lowering treatment reduces aromatase activity in response to follicle-stimulating hormone in women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Lack of an association between CYP1A1 gene Ile462Val polymorphism and polycystic ovary syndrome in Chinese.
Polycystic Ovary Syndrome
Modulation of steroidogenesis by vitamin D3 in granulosa cells of the mouse model of polycystic ovarian syndrome.
Polycystic Ovary Syndrome
No evidence of mutations in the P450 aromatase gene in patients with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Placental steroidogenesis in pregnant women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Role of A-kinase anchoring protein 95 in the regulation of cytochrome P450 family 19 subfamily A member 1 (CYP19A1) in human ovarian granulosa cells.
Polycystic Ovary Syndrome
Role of epigenetic modifications in the aberrant CYP19A1 gene expression in polycystic ovary syndrome.
Polycystic Ovary Syndrome
SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients.
Polycystic Ovary Syndrome
The (TTTA)n polymorphism in intron 4 of CYP19 and the polycystic ovary syndrome risk in a Chinese population.
Polycystic Ovary Syndrome
The relationship between the CYP19 alleles rs727479A/C, rs700518A/G, and rs700519C/T and pregnancy outcome after assisted reproductive technology in patients with polycystic ovary syndrome in a Chinese population: A population-based study.
Polycystic Ovary Syndrome
The single-nucleotide polymorphism rs743572 of CYP17A1 shows significant association with polycystic ovary syndrome: a meta-analysis.
Polycystic Ovary Syndrome
Transcutaneous electrical acupoint stimulation alleviates the hyperandrogenism of polycystic ovarian syndrome rats by regulating the expression of P450arom and CTGF in the ovaries.
Polycystic Ovary Syndrome
Typical hormonal profiles are accompanied by increased immunoreactivity of theca folliculi steroid 17 alpha-hydroxylase P450 in polycystic ovary syndrome.
Polycystic Ovary Syndrome
[Polymorphism of CYP11A1 gene in Chinese patients with polycystic ovarian syndrome]
Polycythemia
CYP17A1 and CYP2E1 variants associated with high altitude polycythemia in Tibetans at the Qinghai-Tibetan Plateau.
Polycythemia Vera
CYP1AI, glutathione S-transferase gene polymorphisms and risk of Polycythemia vera.
Polyendocrinopathies, Autoimmune
Autoimmunity to steroid-producing cells and familial polyendocrine autoimmunity.
Polyendocrinopathies, Autoimmune
Novel AIRE mutations and P450 cytochrome autoantibodies in Central and Eastern European patients with APECED.
Porphyria Cutanea Tarda
Association between CYP1A2 polymorphism and susceptibility to porphyria cutanea tarda.
Porphyria Cutanea Tarda
Comprehensive cytochrome P450 CYP1A2 gene analysis in French caucasian patients with familial and sporadic porphyria cutanea tarda.
Porphyria Cutanea Tarda
Cytochrome P450 induction, uroporphyrinogen decarboxylase depression, porphyrin accumulation and excretion, and gender influence in a 3-week rat model of porphyria cutanea tarda.
Porphyria Cutanea Tarda
Hepatic arachidonic acid metabolism is disrupted after hexachlorobenzene treatment.
Porphyria Cutanea Tarda
No significant association between CYP1A2 polymorphism and porphyria cutanea tarda.
Porphyria Cutanea Tarda
Smoking but not homozygosity for CYP1A2 g-163A allelic variant leads to earlier disease onset in patients with sporadic porphyria cutanea tarda.
Porphyria Cutanea Tarda
Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.
Porphyria, Acute Intermittent
High penetrance of acute intermittent porphyria in a Spanish founder mutation population and CYP2D6 genotype as a susceptibility factor.
Porphyrias
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced porphyria in genetically inbred mice: partial antagonism and mechanistic studies.
Porphyrias
Absolute requirement for iron in the development of chemically induced uroporphyria in mice treated with 3-methylcholanthrene and 5-aminolevulinate.
Porphyrias
Association between CYP1A2 polymorphism and susceptibility to porphyria cutanea tarda.
Porphyrias
Comparative toxicity of polychlorinated biphenyls to Japanese quail (Coturnix c. japonica) and American kestrels (Falco sparverius).
Porphyrias
Comprehensive cytochrome P450 CYP1A2 gene analysis in French caucasian patients with familial and sporadic porphyria cutanea tarda.
Porphyrias
Cytochrome P450 induction, uroporphyrinogen decarboxylase depression, porphyrin accumulation and excretion, and gender influence in a 3-week rat model of porphyria cutanea tarda.
Porphyrias
Effects of heme arginate on cytochrome P450-mediated metabolism of drugs in patients with variegate porphyria and in healthy men.
Porphyrias
Formation of N-alkylprotoporphyrin IX after interaction of porphyrinogenic xenobiotics with rat liver microsomes.
Porphyrias
Formation of N-methyl protoporphyrin in chemically-induced protoporphyria. Studies with a novel porphyrogenic agent.
Porphyrias
Hepatic arachidonic acid metabolism is disrupted after hexachlorobenzene treatment.
Porphyrias
High penetrance of acute intermittent porphyria in a Spanish founder mutation population and CYP2D6 genotype as a susceptibility factor.
Porphyrias
Identification of human hepatic cytochrome P450 sources of N-alkylprotoporphyrin IX after interaction with porphyrinogenic xenobiotics, implications for detection of xenobiotic-induced porphyria in humans.
Porphyrias
Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism.
Porphyrias
Microsomal enzyme induction and clinical aggravation of porphyria: the evaluation of human urinary 6beta-hydroxycortisol/cortisol ratio as the index of hepatic CYP3A4 activity.
Porphyrias
Modulation by iron of hepatic microsomal and nuclear cytochrome P450, and cytosolic glutathione S-transferase and peroxidase in C57BL/10ScSn mice induced with polychlorinated biphenyls (Aroclor 1254).
Porphyrias
Mutation frequency in the lacI gene of liver DNA from lambda/lacI transgenic mice following the interaction of PCBs with iron causing hepatic cancer and porphyria.
Porphyrias
No significant association between CYP1A2 polymorphism and porphyria cutanea tarda.
Porphyrias
Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice.
Porphyrias
Smoking but not homozygosity for CYP1A2 g-163A allelic variant leads to earlier disease onset in patients with sporadic porphyria cutanea tarda.
Porphyrias
The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice.
Porphyrias
Uroporphyrin accumulation associated with cytochrome P4501A induction in fish hepatoma cells exposed to aryl hydrocarbon receptor agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and planar chlorobiphenyls.
Porphyrias
Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.
Porphyrias, Hepatic
Cytochrome p450A1 polymorphisms in a Caucasian population with porphyria cutanea tarda.
Porphyrias, Hepatic
Effect of haem arginate therapy on porphyrin metabolism and mixed function oxygenase activity in acute hepatic porphyria.
Porphyrias, Hepatic
Effects of repeated administration with CP-55,940, a cannabinoid CB1 receptor agonist on the metabolism of the hepatic heme.
Porphyrias, Hepatic
Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone.
Porphyrias, Hepatic
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Porphyrias, Hepatic
Interaction of hexachlorobenzene with the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro and in vivo. Evidence that hexachlorobenzene is a weak Ah receptor agonist.
Postpartum Hemorrhage
Anticonvulsants and the risk of perinatal bleeding complications: A pregnancy cohort study.
Prader-Willi Syndrome
Pharmacogenetic Testing of Cytochrome P450 Drug Metabolizing Enzymes in a Case Series of Patients with Prader-Willi Syndrome.
Pre-Eclampsia
8C.05: EPOXYEICOSATRIENOIC ACIDS ARE INCREASED IN PLACENTAS OF PREECLAMPTIC PREGNANCIES.
Pre-Eclampsia
Arachidonic acid metabolites of CYP4A and CYP4F are altered in women with preeclampsia.
Pre-Eclampsia
Associations of polymorphisms of CYP2D6 and CYP2C9 with early onset severe pre-eclampsia and response to labetalol therapy.
Pre-Eclampsia
Cytochrome P450 metabolites of arachidonic acid in the control of renal function.
Pre-Eclampsia
Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia.
Pre-Eclampsia
Cytochrome P450-mediated metabolic alterations in preeclampsia evaluated by quantitative steroid signatures.
Pre-Eclampsia
Diverse mechanisms of endothelium-derived hyperpolarizing factor-mediated dilatation in small myometrial arteries in normal human pregnancy and preeclampsia.
Pre-Eclampsia
Early onset pre-eclampsia is associated with altered DNA methylation of cortisol-signalling and steroidogenic genes in the placenta.
Pre-Eclampsia
Increased epoxyeicosatrienoic acids and reduced soluble epoxide hydrolase expression in the preeclamptic placenta.
Pre-Eclampsia
Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia.
Pre-Eclampsia
Maternal and fetal epoxyeicosatrienoic acids in normotensive and preeclamptic pregnancies.
Pre-Eclampsia
Maternal vitamin D status in preeclampsia: seasonal changes are not influenced by placental gene expression of vitamin D metabolizing enzymes.
Pre-Eclampsia
OS066. Intrauterine CYP2J2 expression and circulatingepoxyeicosatrienoic acid levels in preeclampsia.
Pre-Eclampsia
Second-Trimester Maternal Serum Paraxanthine, CYP1A2 Activity, and the Risk of Severe Preeclampsia.
Pre-Eclampsia
Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes.
Precancerous Conditions
[Smoking and induction of the enzyme aryl hydrocarbon hydroxylase in patients with laryngeal carcinomas and precancerous conditions]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
CYP3A5 and NAT2 gene polymorphisms: role in childhood acute lymphoblastic leukemia risk and treatment outcome.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
CYP3A5 FNx01 3 genetic polymorphism is associated with childhood acute lymphoblastic leukemia risk: A meta-analysis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cytochrome P4501A1 polymorphism is associated with susceptibility to acute lymphoblastic leukemia in adult Mexican patients.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Differential interactions of Cytochrome P450 3A5 and 3A4 with chemotherapeutic agent- vincristine: A comparative molecular dynamics study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Does cytochrome P450 1A1 MspI polymorphism increase acute lymphoblastic leukemia risk? Evidence from 2013 cases and 2903 controls.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Gene variants of CYP1A1 and CYP2D6 and the risk of childhood acute lymphoblastic leukaemia; outcome of a case control study from Kashmir, India.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic polymorphism of CYP1A1, CYP2D6, GSTM1 and GSTT1 and susceptibility to acute lymphoblastic leukaemia in Indian children.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic polymorphisms and vincristine-induced peripheral neuropathy in patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic polymorphisms of CYP1A1 and risk of leukemia: a meta-analysis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic polymorphisms of CYP1A1, CYP2D6, GSTM1, and GSTT1 and susceptibility to acute lymphoblastic leukemia in Indian children.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic polymorphisms of NQO1, CYP1A1 and TPMT and susceptibility to acute lymphoblastic leukemia in a Tunisian population.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genotype-Environment Interaction Analysis of NQO1, CYP2E1, and NAT2 Polymorphisms and the Risk of Childhood Acute Lymphoblastic Leukemia: A Report From the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Impact of aberrant DNA methylation patterns including CYP1B1 methylation in adolescents and young adults with acute lymphocytic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Impact of CYP1A1, GSTP1 and XRCC1 genes polymorphisms on toxicity and response to chemotherapy in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Low constitutive activity of aryl hydrocarbon hydroxylase in phytohaemoagglutinin-stimulated peripheral blood mononuclear cells of children after treatment for acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pedigree analysis of aryl hydrocarbon hydroxylase inducibility in acute leukemia of childhood.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polymorphism of CYP1A1 gene and susceptibility to childhood acute lymphoblastic leukemia in Egypt.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polymorphisms in CYP1A1 and ethnic-specific susceptibility to acute lymphoblastic leukemia in children.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polymorphisms in genes involved in vincristine pharmacokinetics or pharmacodynamics are not related to impaired motor performance in children with leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Role of CXCL12, TP53 and CYP1A1 gene polymorphisms in susceptibility to pediatric acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Significance of genetic polymorphisms at multiple loci of CYP2E1 in the risk of development of childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Susceptibility to childhood acute lymphoblastic leukemia: influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 genetic polymorphisms.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
CYP2B6 gene single nucleotide polymorphisms and leukemia susceptibility.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
The impact of CYP3A5*3 on risk and prognosis in childhood acute lymphoblastic leukemia.
Pregnancy Complications
Adverse birth outcomes associated with maternal smoking and polymorphisms in the N-Nitrosamine-metabolizing enzyme genes NQO1 and CYP2E1.
Pregnancy Complications
Effect modification of CPY2E1 and GSTZ1 genetic polymorphisms on associations between prenatal disinfection by-products exposure and birth outcomes.
Pregnancy Complications
The Function of Cytochrome P450 1A1 Enzyme (CYP1A1) and Aryl Hydrocarbon Receptor (AhR) in the Placenta.
Pregnancy, Tubal
Expression of P450 aromatase and 17beta-hydroxysteroid dehydrogenase type 1 at fetal-maternal interface during tubal pregnancy.
Premature Birth
Prediction and associations of preterm birth and its subtypes with eicosanoid enzymatic pathways and inflammatory markers.
Premature Birth
The association among cytochrome P450 3A, progesterone receptor polymorphisms, plasma 17-alpha hydroxyprogesterone caproate concentrations, and spontaneous preterm birth.
Premature Birth
The Function of Cytochrome P450 1A1 Enzyme (CYP1A1) and Aryl Hydrocarbon Receptor (AhR) in the Placenta.
Premature Birth
[Research progress of the gene polymorphisms of metabolic enzyme related to polycyclic aromatic hydrocarbons risk of preterm birth].
Premature Ejaculation
Effects of Grapefruit and Pomegranate Juices on the Pharmacokinetic Properties of Dapoxetine and Midazolam in Healthy Subjects.
Presbycusis
CYP1A1 and GSTs common gene variations and presbycusis risk: a genetic association analysis and a bioinformatics approach.
Primary Myelofibrosis
Ruxolitinib exposure in patients with acute and chronic graft versus host disease in routine clinical practice-a prospective single-center trial.
Primary Ovarian Insufficiency
Adrenal-cortex autoantibodies and steroid-producing cells autoantibodies in patients with Addison's disease: comparison of immunofluorescence and immunoprecipitation assays.
Primary Ovarian Insufficiency
Cytochrome P450 family proteins as potential biomarkers for ovarian granulosa cell damage in mice with premature ovarian failure.
Primary Ovarian Insufficiency
Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritis.
Primary Ovarian Insufficiency
Cytochrome P450 Polymorphisms and their Relationship with Premature Ovarian Failure in Premenopausal Women with Breast Cancer Receiving Doxorubicin and Cyclophosphamide.
Primary Ovarian Insufficiency
Premature Ovarian Failure in Patients with Autoimmune Addison's Disease: Clinical, Genetic, and Immunological Evaluation.
Primary Ovarian Insufficiency
Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity.
Primary Ovarian Insufficiency
The significance of polymorphism and expression of oestrogen metabolism-related genes in Chinese women with premature ovarian insufficiency.
Prolactinoma
Aromatase cytochrome P450 enzyme expression in prolactinomas and its relationship to tumor behavior.
Prolactinoma
Expression of aromatase P450 is increased in spontaneous prolactinomas of aged rats.
Prolactinoma
Increased expression of aromatase cytochrome P450 enzyme is associated with prolactinoma invasiveness in post-menopausal women.
Prostatic Hyperplasia
Association of Androgen Receptor, Prostate-Specific Antigen, and CYP19 Gene Polymorphisms with Prostate Carcinoma and Benign Prostatic Hyperplasia in a North Indian Population.
Prostatic Hyperplasia
Association of CYP1A1, CYP1B1 and CYP17 gene polymorphisms and organochlorine pesticides with benign prostatic hyperplasia.
Prostatic Hyperplasia
Associations of SRD5A2/CYP17/CYP19/VDR gene polymorphisms with the development and clinical progression of benign prostatic hyperplasia: a case-control study in northern Chinese population.
Prostatic Hyperplasia
Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer.
Prostatic Hyperplasia
Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancer.
Prostatic Hyperplasia
Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer.
Prostatic Hyperplasia
Genetic polymorphism in sex hormone metabolism and prostate cancer risk.
Prostatic Hyperplasia
Joint effects of inflammation and androgen metabolism on prostate cancer severity.
Prostatic Hyperplasia
Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue.
Prostatic Hyperplasia
TGF-?1 signaling plays a dominant role in the crosstalk between TGF-?1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells.
Prostatic Hyperplasia
The androgen receptor CAG repeat length polymorphism associates with prostate volume in Finnish men with benign prostatic hyperplasia.
Prostatic Intraepithelial Neoplasia
Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue.
Prostatic Neoplasms
27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6-JAK-STAT3 Signaling in Prostate Cancer Cells.
Prostatic Neoplasms
?-naphthoflavone-derived cytochrome P450 (CYP)1B1 degraders specific for sensitizing CYP1B1-mediated drug resistance to prostate cancer DU145: Structure activity relationship.
Prostatic Neoplasms
A bypass mechanism of abiraterone-resistant prostate cancer: Accumulating CYP17A1 substrates activate androgen receptor signaling.
Prostatic Neoplasms
A multicentre analysis of abiraterone acetate in Canadian patients with metastatic castration-resistant prostate cancer.
Prostatic Neoplasms
A SNP in CYP2C8 is not associated with the development of bisphosphonate-related osteonecrosis of the jaw in men with castrate-resistant prostate cancer.
Prostatic Neoplasms
Abiraterone Acetate Induces CREB1 Phosphorylation and Enhances the Function of the CBP-p300 Complex, Leading to Resistance in Prostate Cancer Cells.
Prostatic Neoplasms
Abiraterone acetate to treat metastatic castration-resistant prostate cancer in combination with prednisone.
Prostatic Neoplasms
All-trans-retinoic acid modulation of drug-metabolizing enzyme activities: investigation with selective metabolic drug probes.
Prostatic Neoplasms
Altered expression of cytochrome P450 enzymes involved in metabolism of androgens and vitamin D in the prostate as a risk factor for prostate cancer.
Prostatic Neoplasms
An LC-MS/MS method for quantification of abiraterone, its active metabolites D(4)-abiraterone (D4A) and 5?-abiraterone, and their inactive glucuronide derivatives.
Prostatic Neoplasms
Analysis of polymorphic patterns in candidate genes in Israeli patients with prostate cancer.
Prostatic Neoplasms
Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer.
Prostatic Neoplasms
Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12.
Prostatic Neoplasms
Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation.
Prostatic Neoplasms
Association between CYP2E1 polymorphisms and susceptibility to prostate cancer.
Prostatic Neoplasms
Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk: a case control study in Japan.
Prostatic Neoplasms
Association between the CYP3A4 and CYP3A5 polymorphisms and cancer risk: a meta-analysis and meta-regression.
Prostatic Neoplasms
Association of androgen metabolism gene polymorphisms with prostate cancer risk and androgen concentrations: Results from the Prostate Cancer Prevention Trial.
Prostatic Neoplasms
Association of CYP1A1 polymorphisms with prostate cancer risk: an updated meta-analysis.
Prostatic Neoplasms
Association of CYP1A1 rs1048943 Polymorphism with Prostate Cancer in Iraqi Men Patients.
Prostatic Neoplasms
Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer.
Prostatic Neoplasms
Association of the CYP1B1 Leu432Val polymorphism with the risk of prostate cancer: a meta-analysis.
Prostatic Neoplasms
Association of the CYP24A1-rs2296241 polymorphism of the vitamin D catabolism enzyme with hormone-related cancer risk: a meta-analysis.
Prostatic Neoplasms
Association of the genetic polymorphism in cytochrome P450 (CYP) 1A1 with risk of familial prostate cancer in a Japanese population: a case-control study.
Prostatic Neoplasms
Association of the genetic polymorphism of the CYP19 intron 4[TTTA]n repeat with familial prostate cancer risk in a Japanese population.
Prostatic Neoplasms
Association of variants in estrogen-related pathway genes with prostate cancer risk.
Prostatic Neoplasms
Association study of cytochrome P450 1A1*2A polymorphism with prostate cancer risk and aggressiveness in Croatians.
Prostatic Neoplasms
Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race.
Prostatic Neoplasms
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing.
Prostatic Neoplasms
Characterization of androgen-regulated expression of CYP3A5 in human prostate.
Prostatic Neoplasms
Combination of polymorphisms from genes related to estrogen metabolism and risk of prostate cancers: the hidden face of estrogens.
Prostatic Neoplasms
Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer.
Prostatic Neoplasms
Constitutive and inducible expression of cytochromes P4501A (CYP1A1 and CYP1A2) in normal prostate and prostate cancer cells.
Prostatic Neoplasms
Correction to: Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk: a case control study in Japan.
Prostatic Neoplasms
Correction: Cytochrome P450 1B1 inhibition suppresses tumorigenicity of prostate cancer via caspase-1 activation.
Prostatic Neoplasms
Cyclin A1 and P450 aromatase promote metastatic homing and growth of stem-like prostate cancer cells in the bone marrow.
Prostatic Neoplasms
CYP 1A1 polymorphism and organochlorine pesticides levels in the etiology of prostate cancer.
Prostatic Neoplasms
CYP17, SRD5A2, CYP1B1, and CYP2D6 gene polymorphisms with prostate cancer risk in North Indian population.
Prostatic Neoplasms
CYP19 TCT tri-nucleotide Del/Del genotype is a susceptibility marker for prostate cancer in a Taiwanese population.
Prostatic Neoplasms
CYP1A1 and GSTM1 polymorphic genotypes in patients with prostate cancer in a Turkish population.
Prostatic Neoplasms
CYP1A1 MspI polymorphism is associated with prostate cancer susceptibility: evidence from a meta-analysis.
Prostatic Neoplasms
CYP1B1 polymorphisms and susceptibility to prostate cancer: a meta-analysis.
Prostatic Neoplasms
CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKC? activation and phosphorylation of XIAP.
Prostatic Neoplasms
CYP1B1 variants are associated with prostate cancer in non-Hispanic and Hispanic Caucasians.
Prostatic Neoplasms
CYP24A1 rs1570669 Variant Has a Protective Effect against Tumors of the Urinary System.
Prostatic Neoplasms
CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer.
Prostatic Neoplasms
CYP3A5 gene polymorphism and risk of prostate cancer in a Japanese population.
Prostatic Neoplasms
CYP3A5 regulates prostate cancer cell growth by facilitating nuclear translocation of AR.
Prostatic Neoplasms
Cytochrome P1B1 (CYP1B1) polymorphisms and cancer risk: a meta-analysis of 52 studies.
Prostatic Neoplasms
Cytochrome P450 1B1 inhibition suppresses tumorigenicity of prostate cancer via caspase-1 activation.
Prostatic Neoplasms
Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer.
Prostatic Neoplasms
Cytochrome P450 2B6 is a growth-inhibitory and prognostic factor for prostate cancer.
Prostatic Neoplasms
Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancer.
Prostatic Neoplasms
Cytochrome P4501A1 and glutathione S-transferase M1 genotypes as risk factors for prostate cancer in Japan.
Prostatic Neoplasms
Cytochrome P4501A1 and microsomal epoxide hydrolase gene polymorphisms: gene-environment interaction and risk of prostate cancer.
Prostatic Neoplasms
Cytochrome p4501A1 gene variants as susceptibility marker for prostate cancer.
Prostatic Neoplasms
Design and synthesis of ?-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation.
Prostatic Neoplasms
Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17?-hydroxylase-C17,20-lyase (Cyp17).
Prostatic Neoplasms
Dietary lipids and environmental xenobiotics as risk factors for prostate cancer: The role of cytochrome P450.
Prostatic Neoplasms
Durable Complete Response to Frontline Docetaxel in an Advanced Prostate Cancer Patient with Favourable CYP1B1 Isoforms: Suggestion for Changing Paradigms?
Prostatic Neoplasms
Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells.
Prostatic Neoplasms
Enzymatic and Nonenzymatic Electrochemical Interaction of Abiraterone (Antiprostate Cancer Drug) with Multiwalled Carbon Nanotube Bioelectrodes.
Prostatic Neoplasms
Epigenetic inactivation of the dioxin-responsive cytochrome P4501A1 gene in human prostate cancer.
Prostatic Neoplasms
Epigenetic regulation of the 1,25-dihydroxyvitamin D(3) 24-hydroxylase (CYP24A1) in colon cancer cells.
Prostatic Neoplasms
Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer.
Prostatic Neoplasms
Evaluation of 19-nor-2alpha-(3-hydroxypropyl)-1alpha,25-dihydroxyvitamin D3 as a therapeutic agent for androgen-dependent prostate cancer.
Prostatic Neoplasms
Expression in human prostate of drug- and carcinogen-metabolizing enzymes: association with prostate cancer risk.
Prostatic Neoplasms
Expression of cytochrome P450 3A4 and its clinical significance in human prostate cancer.
Prostatic Neoplasms
Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells.
Prostatic Neoplasms
Formation of a novel topotecan metabolite in the hormone-independent human prostate carcinoma cell lines DU-145 and PC-3.
Prostatic Neoplasms
Frequency of CYP1B1 homozygous genotype 355T/T in prostate cancer families from Poland.
Prostatic Neoplasms
Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer.
Prostatic Neoplasms
Genetic polymorphism in sex hormone metabolism and prostate cancer risk.
Prostatic Neoplasms
Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population.
Prostatic Neoplasms
Genetic polymorphisms in the cytochrome P450 1A1 and 2E1 genes, smoking, drinking and prostate cancer susceptibility: a case-control study in a Han nationality population in Southern China.
Prostatic Neoplasms
Genetic polymorphisms of hormone-related genes and prostate cancer risk in the Japanese population.
Prostatic Neoplasms
Genetic susceptibility of CYP1A1 gene and risk of pesticide exposure in prostate cancer.
Prostatic Neoplasms
Genetic variants in the CYP24A1 gene are associated with prostate cancer risk and aggressiveness in a Korean study population.
Prostatic Neoplasms
Genetic variants of the CYP1B1 gene as predictors of biochemical recurrence after radical prostatectomy in localized prostate cancer patients.
Prostatic Neoplasms
Genetic Variation in the Vitamin D Pathway in Relation to Risk of Prostate Cancer - Results from the Breast and Prostate Cancer Cohort Consortium (BPC3).
Prostatic Neoplasms
Germ-line genetic variation in the key androgen-regulating genes androgen receptor, cytochrome P450, and steroid-5-alpha-reductase type 2 is important for prostate cancer development.
Prostatic Neoplasms
High prevalence of potential drug-drug interactions in patients with castration-resistant prostate cancer treated with abiraterone acetate.
Prostatic Neoplasms
Hormone receptor-related gene polymorphisms and prostate cancer risk in North Indian population.
Prostatic Neoplasms
Human CYP1B1 Leu432Val gene polymorphism: ethnic distribution in African-Americans, Caucasians and Chinese; oestradiol hydroxylase activity; and distribution in prostate cancer cases and controls.
Prostatic Neoplasms
Impact of CYP1A1, GSTM1, and GSTT1 polymorphisms in overall and specific prostate cancer survival.
Prostatic Neoplasms
Impact of IGF-I and CYP19 gene polymorphisms on the survival of patients with metastatic prostate cancer.
Prostatic Neoplasms
In Vitro and In Vivo Drug-Drug Interaction Studies to Assess the Effect of Abiraterone Acetate, Abiraterone, and Metabolites of Abiraterone on CYP2C8 Activity.
Prostatic Neoplasms
Increased expression of CYP24A1 correlates with advanced stages of prostate cancer and can cause resistance to vitamin D3-based therapies.
Prostatic Neoplasms
Influence of lifestyle choices on risks of CYP1B1 polymorphisms for prostate cancer.
Prostatic Neoplasms
Inhibition of aromatase (P450Arom) by some 1-(benzofuran-2-ylmethyl)imidazoles.
Prostatic Neoplasms
Inhibition of Protein Kinase CK2 Reduces Cyp24a1 Expression and Enhances 1,25-Dihydroxyvitamin D3 Antitumor Activity in Human Prostate Cancer Cells.
Prostatic Neoplasms
Inhibitors of the P450 enzymes aromatase and lyase. Crystallographic and molecular modeling studies suggest structural features of pyridylacetic acid derivatives responsible for differences in enzyme inhibitory activity.
Prostatic Neoplasms
Intratumoral Sterol-27-Hydroxylase (CYP27A1) Expression in Relation to Cholesterol Synthesis and Vitamin D Signaling and Its Association with Lethal Prostate Cancer.
Prostatic Neoplasms
Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an exploratory genotype-environment interaction study.
Prostatic Neoplasms
Joint effects of inflammation and androgen metabolism on prostate cancer severity.
Prostatic Neoplasms
Lack of Association of CYP1A1 Polymorphism with Prostate Cancer Susceptibility of Tunisian Men.
Prostatic Neoplasms
Lack of association of GSTT1, GSTM1, GSTO1, GSTP1 and CYP1A1 polymorphisms for susceptibility and outcome in Brazilian prostate cancer patients.
Prostatic Neoplasms
Limited expression of cytochrome p450 17?-hydroxylase/17,20-lyase in prostate cancer cell lines.
Prostatic Neoplasms
Mechanistic study on liver tumor promoting effects of flutamide in rats.
Prostatic Neoplasms
Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy.
Prostatic Neoplasms
No association between a tetranucleotide repeat polymorphism of CYP19 and prostate cancer.
Prostatic Neoplasms
P450 inhibitors of use in medical treatment: focus on mechanisms of action.
Prostatic Neoplasms
Paralogues of porcine aromatase cytochrome P450: a novel hydroxylase activity is associated with the survival of a duplicated gene.
Prostatic Neoplasms
Pharmacokinetic Drug-Drug Interaction of Apalutamide, Part 1: Clinical Studies in Healthy Men and Patients with Castration-Resistant Prostate Cancer.
Prostatic Neoplasms
Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk.
Prostatic Neoplasms
Polymorphism of cytochrome P450 2B6 and prostate cancer risk: a significant association in a Japanese population.
Prostatic Neoplasms
Polymorphisms in androgen metabolism genes AR, CYP1B1, CYP19, and SRD5A2and prostate cancer risk and aggressiveness in Bulgarian patients.
Prostatic Neoplasms
Polymorphisms in estrogen bioactivation, detoxification and oxidative DNA base excision repair genes and prostate cancer risk.
Prostatic Neoplasms
Polymorphisms in estrogen related genes may modify the protective effect of isoflavones against prostate cancer risk in Japanese men.
Prostatic Neoplasms
Polymorphisms in NAT2, CYP2D6, CYP2C19 and GSTP1 and their association with prostate cancer.
Prostatic Neoplasms
Polymorphisms in the CYP1A1 gene are associated with prostate cancer risk.
Prostatic Neoplasms
Polymorphisms in the CYP1B1 gene are associated with increased risk of prostate cancer.
Prostatic Neoplasms
Polymorphisms of CYP1A1, GSTM1, GSTT1, and Prostate Cancer Risk in Turkish Population.
Prostatic Neoplasms
Polymorphisms of Estrogen Metabolism-Related Genes and Prostate Cancer Risk in Two Populations of African Ancestry.
Prostatic Neoplasms
Polymorphisms of GSTM1 and CYP1A1 genes and their genetic susceptibility to prostate cancer in Chinese men.
Prostatic Neoplasms
Positive correlation between single or combined genotypes of CYP1A1 and GSTM1 in relation to prostate cancer in Chilean people.
Prostatic Neoplasms
Prostate cancer risk and aggressiveness associated with the CYP1B1 4326C/G (Leu432Val) polymorphism: a meta-analysis of 2788 cases and 2968 controls.
Prostatic Neoplasms
Quantitative synthesis of the association between the cytochrome P450 1A1 Ile462Val polymorphism and prostate cancer risk.
Prostatic Neoplasms
Regulation of CYP3A4 and CYP3A5 expression and modulation of "intracrine" metabolism of androgens in prostate cells by liganded vitamin D receptor.
Prostatic Neoplasms
Regulation of human CYP27A1 by estrogens and androgens in HepG2 and prostate cells.
Prostatic Neoplasms
Relationship Between Aldosterone Synthase CYP1A1 MspI Gene Polymorphism and Prostate Cancer Risk.
Prostatic Neoplasms
Relationship of Early-Onset Baldness to Prostate Cancer in African-American Men.
Prostatic Neoplasms
Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11alpha in prostate cancer risk and aggressiveness.
Prostatic Neoplasms
Role of CYP3A5 in Modulating Androgen Receptor Signaling and Its Relevance to African American Men with Prostate Cancer.
Prostatic Neoplasms
Serum persistent organic pollutants (POPs) and prostate cancer risk: A case-cohort study.
Prostatic Neoplasms
Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer.
Prostatic Neoplasms
Structure-function analysis of vitamin D(2) analogs as potential inducers of leukemia differentiation and inhibitors of prostate cancer proliferation.
Prostatic Neoplasms
Substitution at carbon 2 of 19-nor-1?,25-dihydroxyvitamin D3 with 3-hydroxypropyl group generates an analogue with enhanced chemotherapeutic potency in PC-3 prostate cancer cells.
Prostatic Neoplasms
Systematic meta-analyses of gene-specific genetic association studies in prostate cancer.
Prostatic Neoplasms
Targeting of CYP17A1 Lyase by VT-464 Inhibits Adrenal and Intratumoral Androgen Biosynthesis and Tumor Growth of Castration Resistant Prostate Cancer.
Prostatic Neoplasms
The environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin induces cytochrome P450 activity in high passage PC 3 and DU 145 human prostate cancer cell lines.
Prostatic Neoplasms
The interaction of CYP3A5 polymorphisms along the androgen metabolism pathway in prostate cancer.
Prostatic Neoplasms
The prostate cancer TMPRSS2:ERG fusion synergizes with the vitamin D receptor (VDR) to induce CYP24A1 expression-limiting VDR signaling.
Prostatic Neoplasms
The role of drug-drug interactions in prostate cancer treatment: Focus on abiraterone acetate/prednisone and enzalutamide.
Prostatic Neoplasms
The role of oestrogen in the pathogenesis of obesity, type 2 diabetes, breast cancer and prostate disease.
Prostatic Neoplasms
The roles of cytochrome P450 enzymes in prostate cancer development and treatment.
Prostatic Neoplasms
Variant in sex hormone-binding globulin gene and the risk of prostate cancer.
Prostatic Neoplasms
Vitamin D Pathway and Other Related Polymorphisms and Risk of Prostate Cancer: Results from the Prostate Cancer Prevention Trial.
Prostatic Neoplasms
Vitamin D receptor activation reduces VCaP xenograft tumor growth and counteracts ERG activity despite induction of TMPRSS2:ERG.
Prostatic Neoplasms
[Correlation of prostate cancer susceptibility with genetic polymorphism of cytochrome P450 2E1, smoking and drinking: a case-control study in the population of Nanjing area]
Prostatic Neoplasms
[Genotype analysis of CYP1A2 IVS4 + 43A/G in patients with prostate cancer]
Prostatic Neoplasms
[Polymorphism of metabolic gene and genetic susceptibility to prostate cancer]
Prostatic Neoplasms
[Relationship between genetic polymorphisms of metabolizing enzymes and prostate cancer]
Prostatic Neoplasms
[Single nucleotide polymorphisms of CYP1A2 and their correlation with prostate cancer].
Prostatic Neoplasms
[Treatment of metastatic castration-resistant prostate cancer : Drug interaction potentials of abiraterone acetate and enzalutamide].
Protein Deficiency
[Effect of protein on the induction and renewal of a cytochrome P-450 complex in the rat liver]
Protein-Energy Malnutrition
Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test.
Protein-Energy Malnutrition
Effect of protein-calorie malnutrition on cytochromes P450 and glutathione S-transferase.
Protein-Energy Malnutrition
Effects of cysteine on metformin pharmacokinetics in rats with protein-calorie malnutrition: partial restoration of some parameters to control levels.
Protein-Energy Malnutrition
Effects of cysteine on the pharmacokinetic parameters of omeprazole in rats with protein-calorie malnutrition: partial restoration of some parameters to control levels by oral cysteine supplementation.
Protein-Energy Malnutrition
Effects of cysteine on the pharmacokinetics of intravenous adriamycin in rats with protein-calorie malnutrition.
Protein-Energy Malnutrition
Pharmacokinetic changes in drugs during protein-calorie malnutrition: correlation between drug metabolism and hepatic microsomal cytochrome P450 isozymes.
Proteinuria
CYP2C9 genotype and pharmacodynamic responses to losartan in patients with primary and secondary kidney diseases.
Proteinuria
CYP3A5 and CYP3A7 genetic polymorphisms affect tacrolimus concentration in pediatric patients with nephrotic range proteinuria.
Proteinuria
Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice.
Proteinuria
Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.
Protozoan Infections
Validation of Human Sterol 14?-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors.
Psoriasis
Alterations in leukocyte aryl hydrocarbon hydroxylase activity associated with treatment and age in psoriasis patients and healthy individuals.
Psoriasis
An investigation of cytochrome p450 (CYP) and glutathione S-transferase (GST) isoenzyme protein expression and related interactions with phototherapy in patients with psoriasis vulgaris.
Psoriasis
Aryl hydrocarbon hydroxylase, epoxide hydrolase, and benzo[a]-pyrene metabolism in human epidermis: comparative studies in normal subjects and patients with psoriasis.
Psoriasis
Aryl Hydrocarbon Receptor and Autophagy-Related Protein Microtubule-Associated Protein Light Chain 3 Expression in Psoriasis.
Psoriasis
Biological products for the treatment of psoriasis: therapeutic targets, pharmacodynamics and disease-drug-drug interaction implications.
Psoriasis
Clinical Pharmacokinetics and Pharmacodynamics of Risankizumab in Psoriasis Patients.
Psoriasis
Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.
Psoriasis
CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway.
Psoriasis
Decreased epidermal aryl hydrocarbon hydroxylase and localized pustular psoriasis.
Psoriasis
Effect of coal tar on cutaneous aryl hydrocarbon hydroxylase induction and anthralin irritancy.
Psoriasis
Effect of tildrakizumab (MK-3222), a high affinity, selective anti-IL23p19 monoclonal antibody, on cytochrome P450 metabolism in subjects with moderate to severe psoriasis.
Psoriasis
Evaluating Potential Disease-Mediated Protein-Drug Interactions in Patients With Moderate-to-Severe Plaque Psoriasis Receiving Subcutaneous Guselkumab.
Psoriasis
Evaluation of Oxidative Stress via Protein Expression of Glutathion S-Transferase and Cytochrome p450 (CYP450) Isoenzymes in Psoriasis Vulgaris Patients Treated with Methotrexate.
Psoriasis
Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2.
Psoriasis
Hepatic cytochrome P450 CYP2C activity in psoriasis: studies using proguanil as a probe compound.
Psoriasis
Lack of Effect of 12-Week Treatment with Risankizumab on the Pharmacokinetics of Cytochrome P450 Probe Substrates in Patients with Moderate to Severe Chronic Plaque Psoriasis.
Psoriasis
Pharmacokinetics of venlafaxine enantiomers and their metabolites in psoriasis patients.
Psoriasis
Secukinumab Treatment Does Not Alter the Pharmacokinetics of the Cytochrome P450 3A4 Substrate Midazolam in Patients With Moderate to Severe Psoriasis.
Psoriasis
Serum Levels of Aryl Hydrocarbon Receptor, Cytochromes P450 1A1 and 1B1 in Patients with Exacerbated Psoriasis Vulgaris.
Psoriasis
Smoking and Pathogenesis of Psoriasis: A Review of Oxidative, Inflammatory, and Genetic Mechanisms.
Psoriasis
Talarozole, a selective inhibitor of P450-mediated all-trans retinoic acid for the treatment of psoriasis and acne.
Psoriasis
Therapeutic Protein Drug Interaction Potential in Subjects With Psoriasis: An Assessment Based on Population Pharmacokinetic Analyses of Sensitive Cytochrome P450 Probe Substrates.
Psychomotor Agitation
Antidepressant-induced akathisia-related homicides associated with diminishing mutations in metabolizing genes of the CYP450 family.
Psychomotor Agitation
Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
Psychomotor Agitation
The influence of the CYP2D6 polymorphism on psychopathological and extrapyramidal symptoms in the patients on long-term antipsychotic treatment.
Pterygium
An association between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 polymorphisma in pterygium.
Pterygium
CYP1A1 protein activity is associated with allelic variation in pterygium tissues and cells.
Puberty, Precocious
Are CYP1A1, CYP17 and CYP1B1 mutation genes involved on girls with precocious puberty? A pilot study.
Puberty, Precocious
Aromatase p450 expression in a feminizing adrenal adenoma presenting as isosexual precocious puberty.
Pulmonary Arterial Hypertension
Activity of the Estrogen-Metabolizing Enzyme Cytochrome P450 1B1 Influences the Development of Pulmonary Arterial Hypertension.
Pulmonary Arterial Hypertension
Dexfenfluramine and the oestrogen metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension.
Pulmonary Arterial Hypertension
Lack of Pharmacokinetic Interactions Between Macitentan and a Combined Oral Contraceptive in Healthy Female Subjects.
Pulmonary Arterial Hypertension
Metabolism study and biological evaluation of bosentan derivatives.
Pulmonary Arterial Hypertension
Potential for pharmacokinetic interactions between ambrisentan and cyclosporine.
Pulmonary Arterial Hypertension
The endothelin receptor antagonist macitentan for the treatment of pulmonary arterial hypertension: A cross-species comparison of its cytochrome P450 induction pattern.
Pulmonary Disease, Chronic Obstructive
A Physiologically Based Pharmacokinetic Model to Predict Potential Drug-Drug Interactions and Inform Dosing of Acumapimod, an Oral p38 MAPK Inhibitor.
Pulmonary Disease, Chronic Obstructive
Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls.
Pulmonary Disease, Chronic Obstructive
Association of CYP2A6 deletion polymorphism with smoking habit and development of pulmonary emphysema.
Pulmonary Disease, Chronic Obstructive
Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Association of Functional Variants of Phase I and II Genes with Chronic Obstructive Pulmonary Disease in a Serbian Population.
Pulmonary Disease, Chronic Obstructive
Association of the CYP1A1 MspI and TNF?-308 polymorphisms with chronic obstructive pulmonary disease in Inner Mongolia.
Pulmonary Disease, Chronic Obstructive
CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD.
Pulmonary Disease, Chronic Obstructive
CYP1B1, VEGFA, BCL2, and CDKN1A Affect the Development of Chronic Obstructive Pulmonary Disease.
Pulmonary Disease, Chronic Obstructive
CYP2B6 genetic polymorphisms influence chronic obstructive pulmonary disease susceptibility in the Hainan population.
Pulmonary Disease, Chronic Obstructive
Cytochrome P450 1B1 and 2C9 Genotypes and Risk of Ischemic Vascular Disease, Cancer, and Chronic Obstructive Pulmonary Disease.
Pulmonary Disease, Chronic Obstructive
Diallyl disulfide prevents cigarette smoke-induced emphysema in mice.
Pulmonary Disease, Chronic Obstructive
Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: A focus on nicotinic receptors and nicotine metabolizing enzyme.
Pulmonary Disease, Chronic Obstructive
Drug metabolism in severe chronic obstructive pulmonary disease: A phenotyping cocktail study.
Pulmonary Disease, Chronic Obstructive
Effect of Steady-State Enoxacin on Single-Dose Pharmacokinetics of Roflumilast and Roflumilast N-Oxide.
Pulmonary Disease, Chronic Obstructive
Effect of verapamil on systemic exposure and safety of umeclidinium and vilanterol: a randomized and open-label study.
Pulmonary Disease, Chronic Obstructive
Expression of cytochrome P450 mRNAs in Type II alveolar cells from subjects with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Flavonoids isolated from loquat (Eriobotrya japonica) leaves inhibit oxidative stress and inflammation induced by cigarette smoke in COPD mice: the role of TRPV1 signaling pathways.
Pulmonary Disease, Chronic Obstructive
Genetic Factors Associated with COPD Depend on the Ancestral Caucasian/Amerindian Component in the Mexican Population.
Pulmonary Disease, Chronic Obstructive
Genetic polymorphisms in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Genetic Polymorphisms of CYP2C9/CYP2C19 in Chronic Obstructive Pulmonary Disease.
Pulmonary Disease, Chronic Obstructive
Genetic polymorphisms of cytochrome p450 and matrix metalloproteinase in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Genetic variations in detoxification enzymes and HIF-1? in Japanese patients with COPD.
Pulmonary Disease, Chronic Obstructive
Genome-Wide Association Analysis of Single Breath Diffusing Capacity of Carbon Monoxide (DLCO).
Pulmonary Disease, Chronic Obstructive
Genome-wide association study of smoking behaviours in patients with COPD.
Pulmonary Disease, Chronic Obstructive
Identification of biomarkers in common chronic lung diseases by co-expression networks and drug-target interactions analysis.
Pulmonary Disease, Chronic Obstructive
Impact of CYP1A1 Polymorphisms on Susceptibility to Chronic Obstructive Pulmonary Disease: A Meta-Analysis.
Pulmonary Disease, Chronic Obstructive
Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population.
Pulmonary Disease, Chronic Obstructive
Inter-individual variation in CYP2A6 activity and chronic obstructive pulmonary disease in smokers: Perspectives for an early predictive marker.
Pulmonary Disease, Chronic Obstructive
The effect of CYP1A2 gene polymorphisms on Theophylline metabolism and chronic obstructive pulmonary disease in Turkish patients.
Pulmonary Disease, Chronic Obstructive
The effect of diesel emission exposure on primary human bronchial epithelial cells from a COPD cohort: N-acetylcysteine as a potential protective intervention.
Pulmonary Disease, Chronic Obstructive
The effect of exposure to crude oil on the immune system. Health implications for people living near oil exploration activities.
Pulmonary Disease, Chronic Obstructive
The Expression Profiles of ADME Genes in Human Cancers and Their Associations with Clinical Outcomes.
Pulmonary Disease, Chronic Obstructive
Tiotropium bromide. A review of its use as maintenance therapy in patients with COPD.
Pulmonary Disease, Chronic Obstructive
Update in chronic obstructive pulmonary disease: role of antioxidant and metabolizing gene polymorphisms.
Pulmonary Disease, Chronic Obstructive
Upregulation of Chitinase 1 in Alveolar Macrophages of HIV-Infected Smokers.
Pulmonary Disease, Chronic Obstructive
Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms.
Pulmonary Disease, Chronic Obstructive
[Association of cytochrome P450 genes polymorphisms (CYP1A1 and CYP1A2) with the development of chronic obstructive pulmonary disease in Bashkortostan]
Pulmonary Disease, Chronic Obstructive
[Association of the nicotine and cigarette smoke toxicants metabolic (CHRNA3/5, CYP2A6, NQO1) and DNA repair genes (XRCC1, XRCC3, XPC, XPA) with chronic obstructive pulmonary disease].
Pulmonary Disease, Chronic Obstructive
[Genetic risk factors for chronic obstructive pulmonary disease (COPD)]
Pulmonary Disease, Chronic Obstructive
[Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases]
Pulmonary Disease, Chronic Obstructive
[The CYP1B1 and CYP2F1 genes polymorphisms frequency in three ethnic groups of Bashkortostan and chronic obstructive pulmonary disease patients]
Pulmonary Edema
Induction and decline of hepatic cytochromes P4501A1 and 1A2 in rats exposed to hyperoxia are not paralleled by changes in glutathione S-transferase-alpha.
Pulmonary Embolism
ARMS test for diagnosis of CYP2C9 and VKORC1 mutation in patients with pulmonary embolism in Han Chinese.
Pulmonary Embolism
Comparison of rivaroxaban mono-therapy and standard-therapy adjusted by CYP2C9 and VKORC1 genotypes in symptomatic pulmonary embolism.
Pulmonary Emphysema
Association between the CYP1A1 gene polymorphism and susceptibility to emphysema and lung cancer.
Pulmonary Emphysema
Association of CYP2A6 deletion polymorphism with smoking habit and development of pulmonary emphysema.
Pulmonary Fibrosis
CYP2E1 regulates the development of radiation-induced pulmonary fibrosis via ER stress- and ROS-dependent mechanisms.
Pulmonary Fibrosis
VKORC1 and CYP2C9 Polymorphisms: A Case Report in a Dutch Family with Pulmonary Fibrosis.
quinine 3-monooxygenase deficiency
Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.
receptor protein-tyrosine kinase deficiency
Use of c-Src and c-Fos knockout mice for the studies on the role of c-Src kinase signaling in the expression of toxicity of TCDD.
Rectal Neoplasms
Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk.
Rectal Neoplasms
CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking.
Rectal Neoplasms
CYP2E1 RsaI and 96-bp insertion genetic polymorphisms associated with risk for colorectal cancer.
Rectal Neoplasms
Dietary Flavonoids, CYP1A1 Genetic Variants, and the Risk of Colorectal Cancer in a Korean population.
Rectal Neoplasms
Expression Patterns of Xenobiotic-Metabolizing Enzymes in Tumor and Adjacent Normal Mucosa Tissues among Patients with Colorectal Cancer: The ColoCare Study.
Rectal Neoplasms
Red meat intake, CYP2E1 genetic polymorphisms, and colorectal cancer risk.
Rectal Neoplasms
[Genetic polymorphism in cytochrome P450 2E1, salted food and colorectal cancer susceptibility: a case-control study]
Renal Insufficiency
Apremilast (Otezla). No progress in plaque psoriasis or psoriatic arthritis.
Renal Insufficiency
Assessment of individual CYP2D6 activity in extensive metabolizers with renal failure: comparison of sparteine and dextromethorphan.
Renal Insufficiency
Association of plasma concentration of 4?-hydroxycholesterol with CYP3A5 polymorphism and plasma concentration of indoxyl sulfate in stable kidney transplant recipients.
Renal Insufficiency
Concomitant use of statins and macrolide antibiotics and risk of serious renal events: A nationwide cohort study.
Renal Insufficiency
Determination of dextromethorphan metabolic phenotype by salivary analysis with a reference to genotype in Chinese patients receiving renal hemodialysis.
Renal Insufficiency
Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation.
Renal Insufficiency
Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport.
Renal Insufficiency
Influence of renal failure on cytochrome P450 activity in hypertensive patients using a "cocktail" of antipyrine and nifedipine.
Renal Insufficiency
Pharmacodynamic and pharmacokinetic considerations in geriatric psychopharmacology.
Renal Insufficiency
Renal insufficiency has no effect on the pharmacokinetics of vicriviroc in a ritonavir-containing regimen.
Renal Insufficiency
The hepatic and intestinal metabolic activities of P450 in rats with surgery- and drug-induced renal dysfunction.
Renal Insufficiency, Chronic
25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D.
Renal Insufficiency, Chronic
Assessment of 24,25(OH)(2)D levels does not support FGF23-mediated catabolism of vitamin D metabolites.
Renal Insufficiency, Chronic
Assessment of oral anticoagulation control at pharmacist-managed clinics: A retrospective cohort study.
Renal Insufficiency, Chronic
Association of CYP1A1 gene polymorphism with chronic kidney disease: a case control study.
Renal Insufficiency, Chronic
Calcium pyrophosphate deposition disease revealing a hypersensitivity to vitamin D.
Renal Insufficiency, Chronic
Combined sequence and sequence-structure based methods for analyzing FGF23, CYP24A1 and VDR genes.
Renal Insufficiency, Chronic
Derivation, Validation, and Prognostic Utility of a Prediction Rule for Nonresponse to Clopidogrel: The ABCD-GENE Score.
Renal Insufficiency, Chronic
Differential methylation pattern of xenobiotic metabolizing genes and susceptibility to Balkan endemic nephropathy, in a cohort of Romanian patients.
Renal Insufficiency, Chronic
Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP.
Renal Insufficiency, Chronic
Effect of erythropoietin on hepatic cytochrome P450 expression and function in an adenine-fed rat model of chronic kidney disease.
Renal Insufficiency, Chronic
Effects of CYP3A5 Polymorphism on Rapid Progression of Chronic Kidney Disease: A Prospective, Multicentre Study.
Renal Insufficiency, Chronic
Elevated lipoxygenase and cytochrome P450 products predict progression of chronic kidney disease.
Renal Insufficiency, Chronic
Genetic variance in ABCB1 and CYP3A5 does not contribute toward the development of chronic kidney disease after liver transplantation.
Renal Insufficiency, Chronic
High Prevalence of Kidney Cysts in Patients With CYP24A1 Deficiency.
Renal Insufficiency, Chronic
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Renal Insufficiency, Chronic
In silico identification and screening of CYP24A1 inhibitors: 3D QSAR pharmacophore mapping and molecular dynamics analysis.
Renal Insufficiency, Chronic
Pharmacogenomic associations in ABCB1 and CYP3A5 with acute kidney injury and chronic kidney disease after myeloablative hematopoietic cell transplantation.
Renal Insufficiency, Chronic
Pharmacokinetics of Tecarfarin and Warfarin in Patients with Severe Chronic Kidney Disease.
Renal Insufficiency, Chronic
Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease.
Renal Insufficiency, Chronic
Systematic and quantitative assessment of the effect of chronic kidney disease on CYP2D6 and CYP3A4/5.
Renal Insufficiency, Chronic
The effect of chronic kidney disease on CYP2B expression and activity in male Wistar rats.
Renal Insufficiency, Chronic
The serum 24,25-dihydroxyvitamin D concentration, a marker of vitamin D catabolism, is reduced in chronic kidney disease.
Renal Insufficiency, Chronic
Use of Enantiomeric Bupropion and Hydroxybupropion to Assess CYP2B6 Activity in Glomerular Kidney Diseases.
Renal Insufficiency, Chronic
Use of physiologically-based pharmacokinetic (PBPK) modeling to evaluate the effect of chronic kidney disease on the disposition of hepatic CYP2C8 and OATP1B drug substrates.
Renal Insufficiency, Chronic
Xenobiotic metabolism: the effect of acute kidney injury on non-renal drug clearance and hepatic drug metabolism.
Reperfusion Injury
Accumulation of cytochrome P450 induced by proteasome inhibition during cardiac ischemia.
Reperfusion Injury
Arterial ketone index in assessing liver function and its detoxicative capability after ischemia-reperfusion injury.
Reperfusion Injury
Carbon monoxide-bound red blood cell resuscitation ameliorates hepatic injury induced by massive hemorrhage and red blood cell resuscitation via hepatic cytochrome P450 protection in hemorrhagic shock rats.
Reperfusion Injury
Cardioprotection by sulfaphenazole, a cytochrome p450 inhibitor: mitigation of ischemia-reperfusion injury by scavenging of reactive oxygen species.
Reperfusion Injury
Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats.
Reperfusion Injury
Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice.
Reperfusion Injury
Cytochrome P450 CYP2E1 Suppression Ameliorates Cerebral Ischemia Reperfusion Injury.
Reperfusion Injury
Cytochrome P450 induction by phenobarbital exacerbates warm hepatic ischemia-reperfusion injury in rat livers.
Reperfusion Injury
Cytochrome P450 metabolites of arachidonic acid play a role in the enhanced cardiac dysfunction in diabetic rats following ischaemic reperfusion injury.
Reperfusion Injury
Cytochrome P450 omega-hydroxylase inhibition reduces cardiomyocyte apoptosis via activation of ERK1/2 signaling in rat myocardial ischemia-reperfusion.
Reperfusion Injury
Effects of Cytochrome P450 Inhibition by Cimetidine on the Warm Hepatic Ischemia-Reperfusion Injury in Rats.
Reperfusion Injury
Effects of normothermic hepatic ischemia-reperfusion injury on the in vivo, isolated perfused liver, and microsomal disposition of chlorzoxazone, a cytochrome P450 2E1 probe, in rats.
Reperfusion Injury
Effects of sulfaphenazole derivatives on cardiac ischemia-reperfusion injury: association of cytochrome P450 activity and infarct size.
Reperfusion Injury
Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart.
Reperfusion Injury
Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.
Reperfusion Injury
Inhibition of cardiac cytochrome P450: a new approach to cardiac ischaemia and reperfusion damage.
Reperfusion Injury
Is it possible to predict the early post-transplant allograft function using 20-HETE measurements? A preliminary report.
Reperfusion Injury
Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts.
Reperfusion Injury
Suppression of myocardial ischemia-reperfusion injury by inhibitors of cytochrome P450 in rats.
Reperfusion Injury
[Effect of "Jiaji" (EX-B2)-electroacupuncture preconditioning on expression of myocardial cytochrome P450 enzyme in rats with acute myocardial ischemia-reperfusion injury].
Respiratory Distress Syndrome
CYP1A1, GCLC, AGT, AGTR1 gene-gene interactions in community-acquired pneumonia pulmonary complications.
Respiratory Distress Syndrome
Genetic susceptibility to nosocomial pneumonia, acute respiratory distress syndrome and poor outcome in patients at risk of critical illness.
Respiratory Distress Syndrome, Newborn
Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2.
Respiratory Insufficiency
A Case of Respiratory Depression in a Child With Ultrarapid CYP2D6 Metabolism After Tramadol.
Respiratory Insufficiency
CYP1A1, GCLC, AGT, AGTR1 gene-gene interactions in community-acquired pneumonia pulmonary complications.
Respiratory Insufficiency
Drug-drug interactions and clinical considerations with co-administration of antiretrovirals and psychotropic drugs.
Respiratory Insufficiency
Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication.
Respiratory Tract Diseases
[Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases]
Respiratory Tract Infections
Herbal extracts used for upper respiratory tract infections: are there clinically relevant interactions with the cytochrome P450 enzyme system?
Respiratory Tract Infections
Serious respiratory infections can increase clozapine levels and contribute to side effects: a case report.
Retinal Degeneration
Aryl hydrocarbon hydroxylase induction in retinal pigmented epithelium: possible association of genetic differences in a drug-metabolizing enzyme system with retinal degeneration.
Retinal Degeneration
Ethanol-Induced Oxidative Stress Modifies Inflammation and Angiogenesis Biomarkers in Retinal Pigment Epithelial Cells (ARPE-19): Role of CYP2E1 and its Inhibition by Antioxidants.
Retinal Degeneration
Opposite expression of CYP51A1 and its natural antisense transcript AluCYP51A1 in adenovirus type 37 infected retinal pigmented epithelial cells.
Retinal Degeneration
Oxysterols: functional significance in fetal development and the maintenance of normal retinal function.
retinal dehydrogenase deficiency
Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression levels.
Retinal Dystrophies
Expanding the Phenotypic and Genotypic Spectrum of Bietti Crystalline Dystrophy.
Retinal Neoplasms
[EXOPHTHALMOS, EXCEPTIONAL REVELATORY SIGN OF A TUMOR OF THE OLFACTIVE PLACODE. ESTHESIONEUROEPITHELIOMA. HISTOLOGICAL RELATION OF THIS TUMOR TO NERVOUS RETINAL TUMORS.]
Retinal Neovascularization
Cytochrome P450 Oxidase 2C Inhibition Adds to ?-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization.
Retinal Neovascularization
Targeted deletion of Cyp1b1 in pericytes results in attenuation of retinal neovascularization and trabecular meshwork dysgenesis.
Retinitis Pigmentosa
Research progress on human genes involved in the pathogenesis of glaucoma (Review).
Retrognathia
Parathyroid Hormone Gene and Genes Involved in the Maintenance of Vitamin D Levels Association with Mandibular Retrognathism.
Rhabdomyolysis
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and rhabdomyolysis: considerations in the renal failure patient.
Rhabdomyolysis
A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin.
Rhabdomyolysis
A Screening Study of Drug-Drug Interactions in Cerivastatin Users: An Adverse Effect of Clopidogrel.
Rhabdomyolysis
Alcohol-associated rhabdomyolysis: ethanol induction of cytochrome P450 may potentiate myotoxicity.
Rhabdomyolysis
Atorvastatin-related rhabdomyolysis and acute renal failure in a genetically predisposed patient with potential drug-drug interaction.
Rhabdomyolysis
Cerivastatin in vitro metabolism by CYP2C8 variants found in patients experiencing rhabdomyolysis.
Rhabdomyolysis
Clarification of the Mechanism of Clopidogrel-Mediated Drug-Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information.
Rhabdomyolysis
Fusidic Acid Inhibits Hepatic Transporters and Metabolic Enzymes: Potential Cause of Clinical Drug-Drug Interaction Observed with Statin Coadministration.
Rhabdomyolysis
HMG-CoA reductase inhibitors: assessing differences in drug interactions and safety profiles.
Rhabdomyolysis
Major Cardiac-Psychiatric Drug-Drug Interactions: a Systematic Review of the Consistency of Drug Databases.
Rhabdomyolysis
Multiple organ failure after an overdose of less than 0.4 mg/kg of colchicine: role of coingestants and drugs during intensive care management.
Rhabdomyolysis
Rhabdomyolysis and acute renal failure in a cardiac transplant recipient due to multiple drug interactions.
Rhabdomyolysis
Rhabdomyolysis in an elderly multitreated patient: multiple drug interactions after statin withdrawal.
Rhabdomyolysis
Rhabdomyolysis in an HIV-Infected Patient on Anti-Retroviral Therapy Precipitated by High-Dose Pravastatin.
Rhabdomyolysis
Rhabdomyolysis precipitated by possible interaction of ticagrelor with high-dose atorvastatin.
Rhabdomyolysis
Risk management of simvastatin or atorvastatin interactions with CYP3A4 inhibitors.
Rhabdomyolysis
Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin with rapamycin plus tacrolimus in liver transplant patient.
Rhabdomyolysis
Severe Rhabdomyolysis due to Presumed Drug Interactions between Atorvastatin with Amlodipine and Ticagrelor.
Rhabdomyolysis
Short term treatment with clarithromycin resulting in colchicine-induced rhabdomyolysis.
Rhabdomyolysis
The Case-Crossover Design for Drug-Drug Interactions: Considerations for Implementation.
Rhabdomyolysis
Ticagrelor and Statin Interaction Induces Rhabdomyolysis and Acute Renal Failure: Case reports and Scoping Review.
Rhabdomyolysis
[Rhabdomyolysis in patients treated with simvastatin and cyclosporin: role of the hepatic cytochrome P450 enzyme system activity]
Rhabdomyosarcoma
Differential expression of cytochrome p450 enzymes in normal and tumor tissues from childhood rhabdomyosarcoma.
Rheumatic Diseases
Lack of pharmacokinetic interaction between pantoprazole and diclofenac.
Rheumatic Heart Disease
Clinical application of pharmacogenetic-based warfarin-dosing algorithm in patients of han nationality after rheumatic valve replacement: a randomized and controlled trial.
Rhinitis, Allergic
[Significance of CYP2D6 oxidation genotype as a risk factor in development of allergic diseases]
Riboflavin Deficiency
Hepatic drug metabolism during ethanol ingestion in riboflavin deficient rats.
Riboflavin Deficiency
Phenobarbital induced variations in hepatic ethyl-morphine n-demethylase and inorganic pyrophosphatase during riboflavin deficiency.
Riboflavin Deficiency
Possible role of riboflavin deficiency in epithelial neoplasia. 3. Induction of microsomal aryl hydrocarbon hydroxylase.
Rickets
Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450 subunit maps to a different chromosomal location than that of pseudovitamin D-deficient rickets.
Rickets
Relationship between polymorphisms in vitamin D metabolism-related genes and the risk of rickets in Han Chinese children.
Rickets
Structure-function analysis of CYP27B1 and CYP27A1. Studies on mutants from patients with vitamin D-dependent rickets type I (VDDR-I) and cerebrotendinous xanthomatosis (CTX).
Rickets
Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets.
Rickets
The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus.
Sarcoidosis
Iatrogenic vitamin D toxicity in an infant - a case report and review of literature.
Sarcoma
A comparison between lung carcinoma and a subcutaneous malignant tumor induced in rats by a 3,4-benzopyrene injection.
Sarcoma
Aromatase cytochrome P450 and estrogen and progesterone receptors in uterine sarcomas: correlation with clinical parameters.
Sarcoma
Rank order of sarcoma susceptibility among mouse strains reverses with low concentrations of carcinogen.
Sarcoma
Relationships between aryl hydrocarbon hydroxylase inducibility and sensitivity to chemically induced subcutaneous sarcomas in various strains of mice.
Sarcoma, Avian
Evaluation of viral and mammalian promoters for driving transgene expression in mouse liver.
Sarcoma, Avian
Mammalian PC-12 cell genetically engineered for human cytochrome P450 2E1 expression.
Sarcoma, Experimental
Maturation of fetal hepatocytes in vitro by extracellular matrices and oncostatin M: induction of tryptophan oxygenase.
Sarcoma, Kaposi
Pilot study evaluating the interaction between paclitaxel and protease inhibitors in patients with human immunodeficiency virus-associated Kaposi's sarcoma: an Eastern Cooperative Oncology Group (ECOG) and AIDS Malignancy Consortium (AMC) trial.
Scabies
Biosynthesis and evolution of coronafacoyl phytotoxin production in the common scab pathogen Streptomyces scabies.
Scabies
Structural insights into the mechanism for recognizing substrate of the cytochrome P450 enzyme TxtE.
Schistosomiasis
Changes in the expression of cytochrome P450 isozymes and related carcinogen metabolizing enzyme activities in Schistosoma mansoni-infected mice.
Schistosomiasis
Different levels of Schistosoma mansoni infection induce changes in drug-metabolizing enzymes.
Schistosomiasis haematobia
Infection with carcinogenic helminth parasites and its production of metabolites induces the formation of DNA-adducts.
Schistosomiasis mansoni
Changes in the expression of cytochrome P450 isozymes and related carcinogen metabolizing enzyme activities in Schistosoma mansoni-infected mice.
Schistosomiasis mansoni
Different levels of Schistosoma mansoni infection increased the mutagenicity of benzo(a)pyrene, the activity of aryl hydrocarbon hydroxylase and the formation of hepatic microsomal hydrogen peroxide.
Scleroderma, Systemic
Enantioselectivity in the Metabolism of Cyclophosphamide in Patients With Multiple or Systemic Sclerosis.
Scleroderma, Systemic
Genetic polymorphism of CYP2D6 in patients with systemic lupus erythematosus and systemic sclerosis.
Scleroderma, Systemic
Genetic polymorphisms of CYP2D6 oxidation in patients with systemic sclerosis.
Scleroderma, Systemic
Polymorphisms of the xenobiotic-metabolizing enzymes CYP1A1 and NAT-2 in systemic sclerosis and lupus erythematosus.
Scleroderma, Systemic
Significance of genetic polymorphism of CYP2D6 in the pathogenesis of systemic sclerosis.
Scrapie
Comprehensive gene expression analysis in human periodontal ligaments of the mandibular third molars performing vertical movement and the maxillary second premolars with occlusal contact.
Seizures
A puzzling case of seizures and visual hallucinations during clomipramine treatment with a high dose but causing a low serum concentration.
Seizures
Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and ?-Subunit-Containing Gamma-Aminobutyric Acid A Receptors.
Seizures
Association of CYP2D6 100 C > T and 2850 C > T polymorphisms with generalized tonic clonic seizures among Indians.
Seizures
Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism.
Seizures
Correspondence of increased debrisoquine 4-monooxygenase activity with seizure-susceptibility in Mongolian gerbils.
Seizures
Early post-traumatic seizures are associated with valproic acid plasma concentrations and UGT1A6/CYP2C9 genetic polymorphisms in patients with severe traumatic brain injury.
Seizures
Effect of lindane on hepatic and brain cytochrome P450s and influence of P450 modulation in lindane induced neurotoxicity.
Seizures
Effects of cytochrome P450 (CYP)2C19 polymorphisms on pharmacokinetics of phenobarbital in neonates and infants with seizures.
Seizures
Genetic polymorphisms in sex hormone metabolizing genes and drug response in women with epilepsy.
Seizures
Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N?=?1345 young and elderly subjects.
Seizures
Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures.
Seizures
Herbal medicine and epilepsy: proconvulsive effects and interactions with antiepileptic drugs.
Seizures
Induction of pulmonary cytochrome P4501A1: interactive effects of nicotine and mecamylamine.
Seizures
Induction or inhibition of cytochrome P450 2E1 modifies the acute toxicity of acrylonitrile in rats: biochemical evidence.
Seizures
Long-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin.
Seizures
Maternal intake of docosahexaenoic acid decreased febrile seizure sensitivity by increasing estrogen synthesis in offspring.
Seizures
P450 enzyme-inducing and non-enzyme-inducing antiepileptic drugs for seizure prophylaxis after glioma resection surgery: a meta-analysis.
Seizures
Potentiation of 17?-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid.
Seizures
Reproductive dysfunction in women with epilepsy: antiepileptic drug effects on sex-steroid hormones.
Seizures
Seizures and myoclonus associated with antidepressant treatment: assessment of potential risk factors, including CYP2D6 and CYP2C19 polymorphisms, and treatment with CYP2D6 inhibitors.
Seizures
Susceptibility to the acute toxicity of acrylonitrile in streptozotocin-induced diabetic rats: protective effect of phenethyl isothiocyanate, a phytochemical CYP2E1 inhibitor.
Seizures
The CYP1A2 -163C>A polymorphism is associated with clozapine-induced generalized tonic-clonic seizures in Brazilian schizophrenia patients.
Sepsis
Correction to: Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis.
Sepsis
Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis.
Sepsis
Cytochrome P450 activity mirrors nitric oxide levels in postoperative sepsis: predictive indicators of lethal outcome.
Sepsis
Down-regulation of hepatic CYP1A2 plays an important role in inflammatory responses in sepsis.
Sepsis
Downregulation of hepatic cytochrome P-450 isoforms and PPAR-gamma: their role in hepatic injury and proinflammatory responses in a double-hit model of hemorrhage and sepsis.
Sepsis
Effect of SPG/Indomethacin treatment on sepsis, interleukin-6 production, and expression of hepatic cytochrome P450 isoforms in differing strains of mice.
Sepsis
Metabolism-mediated drug interaction potential of HS-23, a new herbal drug for the treatment of sepsis in human hepatocytes and liver microsomes.
Sepsis
Myocardial transcriptional profiles in a murine model of sepsis: evidence for the importance of age.
Sepsis
On the Role of Illness Duration and Nutrient Restriction in Cholestatic Alterations that Occur During Critical Illness.
Sepsis
Pharmacokinetics and pharmacodynamics of vecuronium in rats with systemic inflammatory response syndrome: treatment with NG-monomethyl-L-arginine.
Sepsis
Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction.
Sepsis
Suppression of hepatic cytochrome p450-mediated drug metabolism during the late stage of sepsis in rats.
Sepsis
Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway: the central role of proinflammatory cytokines.
Sepsis
The beneficial effect of Trolox on sepsis-induced hepatic drug metabolizing dysfunction.
Sepsis
The effect of sepsis during parenteral nutrition on hepatic microsomal function in rats.
Sepsis
The potential role of transcription factor aryl hydrocarbon receptor in downregulation of hepatic cytochrome P-450 during sepsis.
Sepsis
Vitamins C and E protect hepatic cytochrome P450 dysfunction induced by polymicrobial sepsis.
Sertoli Cell-Only Syndrome
Disturbed testicular expression of the estrogen-metabolizing enzymes CYP1A1 and COMT in infertile men with primary spermatogenic failure: possible negative implications on Sertoli cells.
Sertoli Cell-Only Syndrome
Transcripts of testicular gonadotropin-releasing hormone, steroidogenic enzymes, and intratesticular testosterone levels in infertile men.
Sertoli-Leydig Cell Tumor
Expression of P450 Aromatase in Granulosa Cell Tumors and Sertoli-Stromal Cell Tumors of the Ovary: Which Cells Are Responsible for Estrogenesis?
Sertoli-Leydig Cell Tumor
Immunohistochemical studies of steroidogenic enzymes (aromatase, 17 alpha-hydroxylase and cholesterol side-chain cleavage cytochromes P-450) in sex cord-stromal tumors of the ovary.
Sex Cord-Gonadal Stromal Tumors
Expression of P450 Aromatase in Granulosa Cell Tumors and Sertoli-Stromal Cell Tumors of the Ovary: Which Cells Are Responsible for Estrogenesis?
Sexual Infantilism
Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries.
Shock, Cardiogenic
Cardiogenic shock induced by bisoprolol in a patient with CYP2D6 variant. A case report.
Shock, Septic
Bexarotene, a Selective RXR? Agonist, Reverses Hypotension Associated with Inflammation and Tissue Injury in a Rat Model of Septic Shock.
Shock, Septic
Hepatic oxygen consumption and cytochrome P450 activity in experimental faecal peritonitis.
Silicosis
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
Skin Diseases
2,3,7,8-Tetrachlorodibenzo-p-Dioxin Regulates the Expression of Aryl Hydrocarbon Receptor-Related Factors and Cytokines in Peripheral Blood Mononuclear Cells and CD4+ T cells from Patients with Atopic Dermatitis and Psoriasis.
Skin Diseases
Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.
Skin Diseases
CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway.
Skin Diseases
Molecular docking of substrates and inhibitors in the catalytic site of CYP6B1, an insect cytochrome p450 monooxygenase.
Skin Neoplasms
Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond.
Skin Neoplasms
Epigenetic and genetic dissections of UV-induced global gene dysregulation in skin cells through multi-omics analyses.
Skin Neoplasms
Glutathione S-transferase and CYP1A1 gene polymorphisms and non-melanoma skin cancer risk in Italian transplanted patients.
Skin Neoplasms
Immunoreactivity to CYP24A1, but not vitamin D receptor, is increased in mast cells of keratinocyte skin cancers.
Skin Neoplasms
Mast cells express CYP27A1 and CYP27B1 in epithelial skin cancers and psoriasis.
Skin Neoplasms
Retinoic acid antagonizes basal as well as coal tar and glucocorticoid-induced cytochrome P4501A1 expression in human skin.
Sleep Apnea Syndromes
Decreased expression of hepatic cytochrome P450 1A2 (CYP1A2) in a chronic intermittent hypoxia mouse model.
Sleep Apnea, Obstructive
A Case of Respiratory Depression in a Child With Ultrarapid CYP2D6 Metabolism After Tramadol.
Sleep Apnea, Obstructive
Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer.
Sleep Apnea, Obstructive
More codeine fatalities after tonsillectomy in North American children.
Sleep Deprivation
Changes in the expression of steroid metabolism-related genes in rat adrenal glands during selective REM sleep deprivation.
Sleep Initiation and Maintenance Disorders
Effects of genetic polymorphisms of CYP2C19 on the pharmacokinetics of zolpidem.
Sleep Initiation and Maintenance Disorders
Pharmacogenetic Associations Between Atazanavir/UGT1A1*28 and Efavirenz/rs3745274 (CYP2B6) Account for Specific Adverse Reactions in Chilean Patients Undergoing Antiretroviral Therapy.
Sleep Initiation and Maintenance Disorders
Pharmacokinetic Interactions Between the Orexin Receptor Antagonist Almorexant and the CYP3A4 Inhibitors Ketoconazole and Diltiazem.
Sleep Initiation and Maintenance Disorders
Physiologically-based pharmacokinetic modeling to predict drug interactions of lemborexant with CYP3A inhibitors.
Small Cell Lung Carcinoma
Altered regulation of the cytochrome P4501A1 gene: novel inducer-independent gene expression in pulmonary carcinoma cell lines.
Small Cell Lung Carcinoma
CYP1A1 and CYP2D6 polymorphism and risk of lung cancer in a North Indian population.
Small Cell Lung Carcinoma
Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines.
Small Cell Lung Carcinoma
[Applications of aryl hydrocarbon hydroxylase in diagnosis of lung cancer]
Small Cell Lung Carcinoma
[Association of CYP1A1 Ile462Val polymorphisms with susceptibility to small cell lung cancer].
Smith-Lemli-Opitz Syndrome
Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate.
Spastic Paraplegia, Hereditary
CYP7B1: novel mutations and magnetic resonance spectroscopy abnormalities in hereditary spastic paraplegia type 5A.
Spastic Paraplegia, Hereditary
Generation of induced pluripotent stem cells (iPSCs) from a hereditary spastic paraplegia patient carrying a homozygous R486C mutation in CYP7B1 (SPG5).
Spastic Paraplegia, Hereditary
Generation of induced pluripotent stem cells (iPSCs) from a hereditary spastic paraplegia patient carrying a homozygous Y275X mutation in CYP7B1 (SPG5).
Spastic Paraplegia, Hereditary
Mining for Oxysterols in Cyp7b1-/- Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5.
Spastic Paraplegia, Hereditary
Structural and dynamic basis of human cytochrome P450 7B1: a survey of substrate selectivity and major active site access channels.
Spondylitis, Ankylosing
Association between Functional CYP2D6 Polymorphisms and Susceptibility to Autoimmune Diseases: A Meta-Analysis.
Spondylitis, Ankylosing
Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis.
Spondylitis, Ankylosing
Influence of CYP2C9 and COX-2 Genetic Polymorphisms on Clinical Efficacy of Non-Steroidal Anti-Inflammatory Drugs in Treatment of Ankylosing Spondylitis.
Spondylitis, Ankylosing
Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis.
Spondylitis, Ankylosing
Relationship between genotype for the cytochrome P450 CYP2D6 and susceptibility to ankylosing spondylitis and rheumatoid arthritis.
Squamous Cell Carcinoma of Head and Neck
Analysis of RNA from brush cytology detects changes in B2M, CYP1B1 and KRT17 levels with OSCC in tobacco users.
Squamous Cell Carcinoma of Head and Neck
Anticancer effects of NSC?631570 (Ukrain) in head and neck cancer cells: In vitro analysis of growth, invasion, angiogenesis and gene expression.
Squamous Cell Carcinoma of Head and Neck
Association and treatment response to capecitabine-based chemoradiotherapy with CYP2C9 polymorphism in head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
Association between CYP1A1 Ile462Val Polymorphism and Oral Squamous Cell Carcinoma Susceptibility: Evidence from 13 Investigations.
Squamous Cell Carcinoma of Head and Neck
Association between GSTM1 and CYP1A1 polymorphisms and survival in oral cancer patients.
Squamous Cell Carcinoma of Head and Neck
Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue.
Squamous Cell Carcinoma of Head and Neck
Association of cytochrome P450 1B1 haplotypes with head and neck cancer risk.
Squamous Cell Carcinoma of Head and Neck
Association of cytochrome P450 2C9 polymorphism with locally advanced head and neck squamous cell carcinoma and response to concurrent cisplatin-based radical chemoradiation.
Squamous Cell Carcinoma of Head and Neck
Association of cytochrome P450 2E1 polymorphisms and head and neck squamous cell cancer.
Squamous Cell Carcinoma of Head and Neck
Association of Genetic Polymorphisms of Aldehyde Dehydrogenase-2 and Cytochrome P450 2E1-RsaI and Alcohol Consumption with Oral Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Association of polymorphism in cytochrome P450 2C9 with susceptibility to head and neck cancer and treatment outcome.
Squamous Cell Carcinoma of Head and Neck
Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes.
Squamous Cell Carcinoma of Head and Neck
CYP1A1 and GSTP1 polymorphisms in an oral cancer case-control study.
Squamous Cell Carcinoma of Head and Neck
CYP1A1 and XRCC1 gene polymorphisms in SCC of the larynx.
Squamous Cell Carcinoma of Head and Neck
CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta-analysis.
Squamous Cell Carcinoma of Head and Neck
CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
CYP1A1, GSTM1 and GSTT1 polymorphisms, tobacco and alcohol status and risk of head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
CYP1A2*1C, CYP2E1*5B, and GSTM1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients.
Squamous Cell Carcinoma of Head and Neck
Cytochrome P450 2E1 and head and neck cancer: Interaction with genetic and environmental risk factors.
Squamous Cell Carcinoma of Head and Neck
Differential induction of CYP1A1 and CYP1B1 by benzo[a]pyrene in oral squamous cell carcinoma cell lines and by tobacco smoking in oral mucosa.
Squamous Cell Carcinoma of Head and Neck
Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis.
Squamous Cell Carcinoma of Head and Neck
Evaluation of CYP1B1 Expression, Oxidative Stress and Phase 2 Detoxification Enzyme Status in Oral Squamous Cell Carcinoma Patients.
Squamous Cell Carcinoma of Head and Neck
Expression and Possible Molecular Mechanisms of microRNA-205-5p in Patients With Head and Neck Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Expression profiling of CYP1B1 in oral squamous cell carcinoma: counterintuitive downregulation in tumors.
Squamous Cell Carcinoma of Head and Neck
Gene polymorphisms in detoxification enzymes as susceptibility factor for head and neck cancer?
Squamous Cell Carcinoma of Head and Neck
Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use.
Squamous Cell Carcinoma of Head and Neck
Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population.
Squamous Cell Carcinoma of Head and Neck
Genetic polymorphisms in Cytochrome P4501B1 and susceptibility to Head and Neck Cancer.
Squamous Cell Carcinoma of Head and Neck
Genetic Polymorphisms of ADH1C and CYP2E1 and Risk of Oral Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Genetically high susceptibility to oral squamous cell carcinoma in terms of combined genotyping of CYP1A1 and GSTM1 genes.
Squamous Cell Carcinoma of Head and Neck
Glutathione S-transferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions.
Squamous Cell Carcinoma of Head and Neck
Head and neck squamous-cell cancer and its association with polymorphic enzymes of xenobiotic metabolism and repair.
Squamous Cell Carcinoma of Head and Neck
Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.
Squamous Cell Carcinoma of Head and Neck
Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response.
Squamous Cell Carcinoma of Head and Neck
Lack of association among polymorphic xenobiotic-metabolizing enzyme genotypes and the occurrence and progression of oral carcinoma in a Brazilian population.
Squamous Cell Carcinoma of Head and Neck
Meta-analyses of the effect of CYP1A1 and CYP2D6 polymorphisms on the risk of head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
miR?543 acts as a novel oncogene in oral squamous cell carcinoma by targeting CYP3A5.
Squamous Cell Carcinoma of Head and Neck
p53, but not p16 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use.
Squamous Cell Carcinoma of Head and Neck
Polymorphism in cytochrome P450 2A6 and glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome.
Squamous Cell Carcinoma of Head and Neck
Polymorphisms of CYP1A1 and GSTM1 genes and susceptibility to oral cancer.
Squamous Cell Carcinoma of Head and Neck
Polymorphisms of GSTT1 and related genes in head and neck cancer risk.
Squamous Cell Carcinoma of Head and Neck
Polymorphisms of the CYP1A1 and CYP2E1 genes in head and neck squamous cell carcinoma risk.
Squamous Cell Carcinoma of Head and Neck
Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose.
Squamous Cell Carcinoma of Head and Neck
Prognostic value of lipid metabolism-related genes in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Protein expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 in young patients with oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Quantitative assessment of the influence of CYP1B1 polymorphisms and head and neck squamous cell carcinoma risk.
Squamous Cell Carcinoma of Head and Neck
Screening and analysis of pathogenic genes during DMBA-induced buccal mucosa carcinogenesis in golden hamsters.
Squamous Cell Carcinoma of Head and Neck
Study the polymorphism of CYP3A5 and CYP3A4 loci in Iranian population with laryngeal squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator.
Squamous Cell Carcinoma of Head and Neck
Tobacco carcinogen-metabolizing genes CYP1A1, GSTM1, and GSTT1 polymorphisms and their interaction with tobacco exposure influence the risk of head and neck cancer in Northeast Indian population.
Squamous Cell Carcinoma of Head and Neck
[Initial results of glutathione-S-transferase GSTM1 and GSTT1 genotypes and genetic predisposition for laryngeal carcinoma]
Stargardt Disease
Cytochrome P450 2C Epoxygenases Mediate Photochemical Stress-induced Death of Photoreceptors.
Starvation
Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect.
Starvation
Changes in the amount of cytochrome P450s in rat hepatic microsomes with starvation.
Starvation
Chlormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver.
Starvation
Combination treatment of epilepsy with ketogenic diet and concurrent pharmacological inhibition of cytochrome P450 2E1.
Starvation
Concentration-dependent changes of PCB patterns in fish-eating mammals: structural evidence for induction of cytochrome P450.
Starvation
Cytochrome P450 family 4 in a cockroach: molecular cloning and regulation by regulation by hypertrehalosemic hormone.
Starvation
Effect of nicotine or cotinine on metabolism of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in isolated rat lung and liver.
Starvation
Effect of polychlorinated biphenyls (Aroclor 1254) on inducible and repressible microsomal N-demethylases in the mouse and rat.
Starvation
Effect of starvation and chlormethiazole on cytochrome P450s of rat nasal mucosa.
Starvation
Effects of starvation on liver microsomal P450 activity in juvenile Pleuronectes americanus.
Starvation
Expression and distribution of cytochrome P450 enzymes in male rat kidney: effects of ethanol, acetone and dietary conditions.
Starvation
Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury.
Starvation
Induction and regulation of cytochrome P450 K-5 (lauric acid hydroxylase) in rat renal microsomes by starvation.
Starvation
Induction mechanisms of cytochrome P450 2E1 in liver: interplay between ethanol treatment and starvation.
Starvation
Lack of cytochrome P450 2E1 (CYP2E1) induction in the rat liver by starvation without coprophagy.
Starvation
Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009).
Starvation
The effect of short-term starvation or water deprivation on caffeine pharmacokinetics in calves.
Starvation
The regulation by gender, strain, dose, and feeding status of the induction of multiple forms of cytochrome P450 isozymes in rat hepatic microsomes by 2,4,5,2',4',5'-hexachlorobiphenyl.
Starvation
Transcriptional control of CYP2E1 in the perivenous liver region and during starvation.
Starvation
Transcriptional responses to starvation stress in the hepatopancreas of oriental river prawn Macrobrachium nipponense.
Starvation
Transcriptomic profiles of Heterobasidion annosum under abiotic stresses and during saprotrophic growth in bark, sapwood and heartwood.
Starvation
[Effect of starvation and acetone on the enzyme systems of biotransformation and toxicity of xenobiotics--CYP2E1 substrates in rats]
Status Epilepticus
Anticonvulsant Activity of Enantiomeric N-trans-Cinnamoyl Derivatives of 2-Aminopropan-1-ols and 2-Aminobutan-1-ols.
Status Epilepticus
Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression.
Status Epilepticus
Status Epilepticus Decreases Brain Cytochrome P450 2D4 Expression in Rats.
steroid 17alpha-monooxygenase deficiency
Isolated 17,20-Lyase Deficiency in a CYB5A Mutated Female With Normal Sexual Development and Fertility.
steroid 21-monooxygenase deficiency
Adrenal C11-oxy C21 steroids contribute to the C11-oxy C19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21-deoxycortisone.
steroid 21-monooxygenase deficiency
Clinical presentation and mutational spectrum in a series of 166 patients with classical 21-hydroxylase deficiency from South China.
steroid 21-monooxygenase deficiency
Functional characterization of two novel point mutations in the CYP21 gene causing simple virilizing forms of congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
steroid 21-monooxygenase deficiency
Glucocorticoid-induced osteoporosis in children with 21-hydroxylase deficiency.
steroid 21-monooxygenase deficiency
Junction site analysis of chimeric CYP21A1P/CYP21A2 genes in 21-hydroxylase deficiency.
steroid 21-monooxygenase deficiency
Protein kinase A, protein kinase C, and Ca(2+)-regulated expression of 21-hydroxylase cytochrome P450 in H295R human adrenocortical cells.
steroid 21-monooxygenase deficiency
Restoration of adrenal steroidogenesis by adenovirus-mediated transfer of human cytochromeP450 21-hydroxylase into the adrenal gland of21-hydroxylase-deficient mice.
steroid 21-monooxygenase deficiency
Why is management of patients with classical congenital adrenal hyperplasia more difficult at puberty?
Stevens-Johnson Syndrome
CYP2C9 polymorphisms in epilepsy: influence on phenytoin treatment.
Stevens-Johnson Syndrome
Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes.
Stomach Neoplasms
A phase II study of perioperative S-1 combined with weekly docetaxel in patients with locally advanced gastric carcinoma: clinical outcomes and clinicopathological and pharmacogenetic predictors for survival.
Stomach Neoplasms
A randomized phase II study of S-1 versus capecitabine as first-line chemotherapy in elderly metastatic gastric cancer patients with or without poor performance status: clinical and pharmacogenetic results.
Stomach Neoplasms
Alteration of cytochrome P-450 and glutathione S-transferase activity in normal and malignant human stomach.
Stomach Neoplasms
Analysis of CYP2E1 polymorphism for the determination of genetic susceptibility to gastric cancer in Koreans.
Stomach Neoplasms
Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta-analysis of 32 case-control studies.
Stomach Neoplasms
Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of stomach cancer: a hospital-based case-control study in Japan.
Stomach Neoplasms
Association of CYP2A6 gene deletion with cancers in Japanese elderly: an autopsy study.
Stomach Neoplasms
Association of CYP2A6 polymorphisms with S-1 plus docetaxel therapy outcomes in metastatic gastric cancer.
Stomach Neoplasms
Associations between CYP2A6 polymorphisms and outcomes of adjuvant S-1 chemotherapy in patients with curatively resected gastric cancer.
Stomach Neoplasms
Bioinformatics analysis to identify action targets in NCI-N87 gastric cancer cells exposed to quercetin.
Stomach Neoplasms
Concurrent expression of aryl hydrocarbon receptor and CYP1A1 but not CYP1A1 MspI polymorphism is correlated with gastric cancers raised in Dalian, China.
Stomach Neoplasms
CYP1A1, CYP2E1, and GSTM1 Gene Polymorphisms and Susceptibility to Colorectal and Gastric Cancer Among Lebanese.
Stomach Neoplasms
CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case-control study within a large-scale population-based prospective study.
Stomach Neoplasms
CYP2A6 and ERCC1 polymorphisms correlate with efficacy of S-1 plus cisplatin in metastatic gastric cancer patients.
Stomach Neoplasms
CYP2A6 Polymorphisms Associate with Outcomes of S-1 Plus Oxaliplatin Chemotherapy in Chinese Gastric Cancer Patients.
Stomach Neoplasms
CYP2E1 changes the biological function of gastric cancer cells via the PI3K/Akt/mTOR signaling pathway.
Stomach Neoplasms
CYP2E1 genetic polymorphism with dietary, tobacco, alcohol habits, H. pylori infection status and susceptibility to stomach cancer in Mizoram, India.
Stomach Neoplasms
CYP2E1 RsaI/PstI polymorphism and gastric cancer susceptibility: meta-analyses based on 24 case-control studies.
Stomach Neoplasms
CYP2E1PstI/RsaI polymorphism and interaction with tobacco, alcohol and GSTs in gastric cancer susceptibility: A meta-analysis of the literature.
Stomach Neoplasms
Cytochrome P450 2E1 genetic polymorphism and gastric cancer in Changle, Fujian Province.
Stomach Neoplasms
Cytochrome P450 2E1 polymorphism in gastric cancer in Brazil: case-control studies of Japanese Brazilians and non-Japanese Brazilians.
Stomach Neoplasms
Dietary aflatoxin B1 intake, genetic polymorphisms of CYP1A2, CYP2E1, EPHX1, GSTM1, and GSTT1, and gastric cancer risk in Korean.
Stomach Neoplasms
Effects of cytochrome P450 (CYP) 2A6 gene deletion and CYP2E1 genotypes on gastric adenocarcinoma.
Stomach Neoplasms
Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer.
Stomach Neoplasms
Frequencies of poor metabolizers of cytochrome P450 2C19 in esophagus cancer, stomach cancer, lung cancer and bladder cancer in Chinese population.
Stomach Neoplasms
Functional PstI/RsaI Polymorphism in CYP2E1 Is Associated with the Development, Progression and Poor Outcome of Gastric Cancer.
Stomach Neoplasms
Gene copy number change events at chromosome 20 and their association with recurrence in gastric cancer patients.
Stomach Neoplasms
Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection.
Stomach Neoplasms
Genetic polymorphisms of the cancer related gene and Helicobacter pylori infection in Japanese gastric cancer patients. An age and gender matched case-control study.
Stomach Neoplasms
Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients.
Stomach Neoplasms
GSTT1, GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population.
Stomach Neoplasms
Helicobacter pylori infection and genetic polymorphisms for cancer-related genes in gastric carcinogenesis.
Stomach Neoplasms
Helicobacter pylori infection, but not genetic polymorphism of CYP2E1, is highly prevalent in gastric cancer patients younger than 40 years.
Stomach Neoplasms
Hypomethylation of the XRE -1383 site is associated with the upregulation of CYP1A1 in gastric adenocarcinoma.
Stomach Neoplasms
Identification of significant pathways in gastric cancer based on protein-protein interaction networks and cluster analysis.
Stomach Neoplasms
Impact of CYP2D6 Polymorphisms on Postoperative Fentanyl Analgesia in Gastric Cancer Patients.
Stomach Neoplasms
Interaction between cytochrome P-450 2E1 polymorphisms and environmental factors with risk of esophageal and stomach cancers in Chinese.
Stomach Neoplasms
Interaction models of CYP1A1, GSTM1 polymorphisms and tobacco smoking in intestinal gastric cancer.
Stomach Neoplasms
LMP2A suppresses the role of AHR pathway through ERK signal pathway in EBV-associated gastric cancer.
Stomach Neoplasms
Localization of Cytochrome P4502E1 Enzyme in Normal and Cancerous Gastric Mucosa and Association with Its Genetic Polymorphism in Unoperated and Remnant Stomach.
Stomach Neoplasms
Meta-analysis of association studies of CYP1A1 genetic polymorphisms with digestive tract cancer susceptibility in Chinese.
Stomach Neoplasms
Meta-analysis of the association of CYP1A1 polymorphisms with gastric cancer susceptibility and interaction with tobacco smoking.
Stomach Neoplasms
Modification effects of GSTM1, GSTT1 and CYP2E1 polymorphisms on associations between raw salted food and incomplete intestinal metaplasia in a high-risk area of stomach cancer.
Stomach Neoplasms
Modulatory effect of naringenin on N-methyl-N'-nitro-N-nitrosoguanidine- and saturated sodium chloride-induced gastric carcinogenesis in male Wistar rats.
Stomach Neoplasms
Polymorphism of CYPIA1 and GSTM1 genes associated with susceptibility of gastric cancer in Shandong Province of China.
Stomach Neoplasms
Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer.
Stomach Neoplasms
Polymorphisms in NEIL-2, APE-1, CYP2E1 and MDM2 Genes are Independent Predictors of Gastric Cancer Risk in a Northern Jiangsu Population (China).
Stomach Neoplasms
Quantitative assessment of the associations between CYP1A1 polymorphisms and gastric cancer risk.
Stomach Neoplasms
Relationship between genetic polymorphisms of drug-metabolizing enzymes (CYP1A1, CYP2E1, GSTM1, and NAT2), drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer.
Stomach Neoplasms
The association study between CYP24A1 gene polymorphisms and risk of liver, lung and gastric cancer in a Chinese population.
Stomach Neoplasms
The effect of CYP1A1 and CYP1A2 polymorphisms on gastric cancer risk among different ethnicities: a systematic review and meta-analysis.
Stomach Neoplasms
The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis.
Stomach Neoplasms
[Activity of cytochrome P450 in the stomach, with special reference to postoperative survival rate of patients with gastric cancer treated by tegafur]
Stomach Neoplasms
[Allelic variants of cytochrome P4501A1 (CYP1A1), glutathione S transferase M1 (GSTM1) polymorphisms and their association with smoking and alcohol consumption as gastric cancer susceptibility biomarkers]
Stomach Neoplasms
[Meta-analysis on association between genetic polymorphisms of cytochrome P450 2E1 and susceptibility to Chinese gastric cancer].
Stomach Neoplasms
[Polymorphisms in detoxification genes CYP1A1, CYP2E1, GSTT1 and GSTM1 in gastric cancer susceptibility]
Stomach Neoplasms
[The distributive features of three kinds of metabolic genes polymorphisms in population of Han nationality in south area of China]
Stomach Neoplasms
[The influence of CYP2A6 polymorphism on adjuvant S-1 chemotherapy outcomes in patients with curatively resected gastric cancer].
Stroke
16(R)-hydroxyeicosatetraenoic acid, a novel cytochrome P450 product of arachidonic acid, suppresses activation of human polymorphonuclear leukocyte and reduces intracranial pressure in a rabbit model of thromboembolic stroke.
Stroke
20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease.
Stroke
Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and ?-Subunit-Containing Gamma-Aminobutyric Acid A Receptors.
Stroke
Association between hypertension and coffee drinking based on CYP1A2 rs762551 single nucleotide polymorphism in Taiwanese.
Stroke
Association of CYP1A1 Gene Polymorphism with Ischemic Stroke in South Indian Population.
Stroke
AVP-923, a combination of dextromethorphan hydrobromide and quinidine sulfate for the treatment of pseudobulbar affect and neuropathic pain.
Stroke
Clinical Application of Genotype-guided Dosing of Warfarin in Patients with Acute Stroke.
Stroke
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.
Stroke
CYP2C19 genotype and early ischemic lesion recurrence in stroke patients treated with clopidogrel.
Stroke
CYP2C8 rs17110453 and EPHX2 rs751141 two-locus interaction increases susceptibility to ischemic stroke.
Stroke
Cytochrome P450 1A1 (CYP1A1) T6325C polymorphism might modulate essential hypertension-associated stroke risk.
Stroke
Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls.
Stroke
Does CYP2C19 polymorphisms affect neurological deterioration in stroke/TIA patients?: A systematic review and meta-analysis of prospective cohort studies.
Stroke
Effect of ticagrelor with clopidogrel on high on-treatment platelet reactivity in acute stroke or transient ischemic attack (PRINCE) trial: Rationale and design.
Stroke
Effects of Triflusal and Clopidogrel on the Secondary Prevention of Stroke Based on Cytochrome P450 2C19 Genotyping.
Stroke
Genetic Polymorphisms of ALOX5AP and CYP3A5 Increase Susceptibility to Ischemic Stroke and Are Associated with Atherothrombotic Events in Stroke Patients.
Stroke
Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke.
Stroke
Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain.
Stroke
Identification and characterization of potent CYP2B6 inhibitors in Woohwangcheongsimwon suspension, an herbal preparation used in the treatment and prevention of apoplexy in Korea and China.
Stroke
Influence of cytochrome P450 polymorphisms on the antiplatelet effects of prasugrel in patients with non-cardioembolic stroke previously treated with clopidogrel.
Stroke
Interaction between ALOX5AP and CYP3A5 gene variants significantly increases the risk for cerebral infarctions in Chinese.
Stroke
Interaction between CYP1A1 T3801C and AHR G1661A polymorphisms according to smoking status on blood pressure in the Stanislas cohort.
Stroke
Interactions Among CYP2C8, EPHX2, and CYP4A11 Variants and CYP Plasma Metabolite Levels in Ischemic Stroke.
Stroke
Investigating Real-World Clopidogrel Pharmacogenetics in Stroke Using a Bioresource Linked to Electronic Medical Records.
Stroke
Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack.
Stroke
Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation.
Stroke
Prevalence of combinatorial CYP2C9 and VKORC1 genotypes in Puerto Ricans: implications for warfarin management in Hispanics.
Stroke
Prevalence of genetic polymorphisms of CYP2C9 and VKORC1 - implications for warfarin management and outcome in Croatian patients with acute stroke.
Stroke
Protocol for the comparison of triflusal and clopidogrel in secondary prevention of stroke based on cytochrome P450 2C19 genotyping (MASETRO study): A multicenter, randomized, open-label, parallel-group trial.
Stroke
Reduction of thyroid hormones triggers down-regulation of hepatic CYP2B through nuclear receptors CAR and TR in a rat model of acute stroke.
Stroke
The influence of CYP1A1 and CYP1A2 polymorphisms on stroke risk in the Chinese population.
Stroke
The role of cytochrome p-450 in salt-sensitive stroke in stroke-prone spontaneously hypertensive rats.
Stroke
The secondary prevention of stroke according to cytochrome P450 2C19 genotype in patients with acute large-artery atherosclerosis stroke.
Stroke
Universal versus genotype-guided use of direct oral anticoagulants in atrial fibrillation patients: a decision analysis.
Stroke
Vascular contributions to cognitive impairment and dementia: the emerging role of 20-HETE.
Stroke
VKORC1 and CYP2C9 Genotype Variations in Relation to Warfarin Dosing in Korean Stroke Patients.
Sturge-Weber Syndrome
Sturge-Weber Syndrome With Congenital Glaucoma and Cytochrome P450 (CYP1B1) Gene Mutations.
Stuttering
Sex steroid hormones and sex hormone binding globulin levels, CYP17 MSP AI (-34T:C) and CYP19 codon 39 (Trp:Arg) variants in children with developmental stuttering.
Subarachnoid Hemorrhage
20-HETE synthesis inhibition promotes cerebral protection after intracerebral hemorrhage without inhibiting angiogenesis.
Subarachnoid Hemorrhage
Evidence that 20-HETE contributes to the development of acute and delayed cerebral vasospasm.
Subarachnoid Hemorrhage
Genetic markers in the EET metabolic pathway are associated with outcomes in patients with aneurysmal subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Pharmacogenomics of Cytochrome P450 of Nimodipine Metabolism After Aneurysmal Subarachnoid Hemorrhage.
Subarachnoid Hemorrhage
Pharmacogenomics of Cytochrome P450 of Nimodipine Metabolism after Aneurysmal Subarachnoid Hemorrhage.
Subarachnoid Hemorrhage
Protective role of p450 epoxyeicosanoids in subarachnoid hemorrhage.
Supranuclear Palsy, Progressive
A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism.
Syncope
CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System-Results From the ADRED Study.
Syncope
Cytochrome P450-2D6 Genotype Definition May Improve Therapy for Paroxysmal Atrial Fibrillation A Case of Syncope Following "Pill-in-the-Pocket" Quinidine plus Propafenone.
Tachycardia
Effect of CYP2D6 genotype on flecainide pharmacokinetics in Japanese patients with supraventricular tachyarrhythmia.
Tachycardia
Effects of CYP2D6 genotypes on age-related change of flecainide metabolism: involvement of CYP1A2-mediated metabolism.
Tachycardia
Propafenone for the prevention of atrial tachyarrhythmias after cardiac surgery: a randomized, double-blind placebo-controlled trial.
Tachycardia, Sinus
[Relationship of blood aryl hydrocarbon receptor mRNA and cytochrome P450 1A1 mRNA expression with corrected QT interval among residents exposed to arsenic via drinking water].
Tachycardia, Ventricular
CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system.
Tardive Dyskinesia
A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia.
Tardive Dyskinesia
Abnormal movements and tardive dyskinesia in smokers and nonsmokers with schizophrenia genotyped for cytochrome P450 2D6.
Tardive Dyskinesia
Antipsychotic drug-induced movement disorders in schizophrenics in relation to CYP2D6 genotype.
Tardive Dyskinesia
Antipsychotic-induced tardive dyskinesia and polymorphic variations in COMT, DRD2, CYP1A2 and MnSOD genes: a meta-analysis of pharmacogenetic interactions.
Tardive Dyskinesia
Association between CYP2D6 genotype and tardive dyskinesia in Korean schizophrenics.
Tardive Dyskinesia
Association of CYP2D6 and CYP1A2 gene polymorphism with tardive dyskinesia in Chinese schizophrenic patients.
Tardive Dyskinesia
Association of serotonin 2A receptor and lack of association of CYP1A2 gene polymorphism with tardive dyskinesia in a Turkish population.
Tardive Dyskinesia
Association of tardive dyskinesia with variation in CYP2D6: Is there a role for active metabolites?
Tardive Dyskinesia
Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
Tardive Dyskinesia
CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects.
Tardive Dyskinesia
CYP2D6 polymorphisms and the risk of tardive dyskinesia in schizophrenia: a meta-analysis.
Tardive Dyskinesia
CYP450 pharmacogenetic treatment strategies for antipsychotics: a review of the evidence.
Tardive Dyskinesia
Cytochrome P450 1A2 co-determines neuroleptic load and may diminish tardive dyskinesia by increased inducibility.
Tardive Dyskinesia
Cytochrome P450 2D6 genotyping and association with tardive dyskinesia in Chinese schizophrenic patients.
Tardive Dyskinesia
Genetic association analysis between CYP2D6*2 allele and tardive dyskinesia in schizophrenic patients
Tardive Dyskinesia
Genetic association analysis of functional polymorphisms in the cytochrome P450 1A2 (CYP1A2) gene with tardive dyskinesia in Japanese patients with schizophrenia.
Tardive Dyskinesia
Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: I. Association of CYP1A2 gene polymorphism.
Tardive Dyskinesia
Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: III. Lack of association of CYP3A4 and CYP2D6 gene polymorphisms.
Tardive Dyskinesia
Genetic susceptibility to Tardive Dyskinesia in chronic schizophrenia subjects: V. Association of CYP1A2 1545 C>T polymorphism.
Tardive Dyskinesia
Lack of association between a functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene and tardive dyskinesia in schizophrenia.
Tardive Dyskinesia
Maintenance therapy with zuclopenthixol decanoate: associations between plasma concentrations, neurological side effects and CYP2D6 genotype.
Tardive Dyskinesia
Pharmacogenomics in schizophrenia: the quest for individualized therapy.
Tardive Dyskinesia
Pharmacogenomics--can genetics help in the care of psychiatric patients?
Tardive Dyskinesia
Polymorphic variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and dopamine D2 and D3 receptors and their association with tardive dyskinesia in severe mental illness.
Tardive Dyskinesia
Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II.
Tardive Dyskinesia
Tardive dyskinesia and debrisoquine 4-hydroxylase (CYP2D6) genotype in Japanese schizophrenics.
Tardive Dyskinesia
The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation.
Tauopathies
Cerebrotendinous xanthomatosis with the c.379C>T (p.R127W) mutation in the CYP27A1 gene associated with premature age-associated limbic tauopathy.
Telangiectasis
Hereditary Haemorrhagic Telangiectasia (HHT) Marked by ACVRL1C1120T Variant Displays Hypopigmented Naevi and Frequent Bleeding Episodes if CYP2C9 Co-Mutated: Clinical Notes & Rationale of Patient Registry.
Telangiectasis
Topical timolol for treatment of epistaxis in hereditary haemorrhagic telangiectasia associated with bradycardia: a look at CYP2D6 metabolising variants.
Teratoma
Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo.
Teratozoospermia
[Genetic genes associated with oligospermia, asthenospermia and teratospermia: Advances in studies].
Testicular Neoplasms
CYP1A1, CYP3A5 and CYP3A7 polymorphisms and testicular cancer susceptibility.
Testicular Neoplasms
Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis.
Testicular Neoplasms
Effect modification of endocrine disruptors and testicular germ cell tumour risk by hormone-metabolizing genes.
Thalassemia
Drug metabolizing enzyme CYP1A2 status in pediatric patients with hemoglobin E-beta thalassemia.
Thalassemia
Modification of CYP2E1 and CYP3A4 activities in haemoglobin E-beta thalassemia patients.
Thecoma
Immunohistochemical studies of steroidogenic enzymes (aromatase, 17 alpha-hydroxylase and cholesterol side-chain cleavage cytochromes P-450) in sex cord-stromal tumors of the ovary.
Thiamine Deficiency
Effects of thiamine deficiency on hepatic cytochromes P450 and drug-metabolizing enzyme activities.
Thiamine Deficiency
The influence of thiamine deficiency on porphyrin synthesis and porphyrin proteins.
thiopurine s-methyltransferase deficiency
Increasing relevance of pharmacogenetics of drug metabolism in clinical practice.
Thrombocytopenia
Drug interaction between itraconazole and bortezomib: exacerbation of peripheral neuropathy and thrombocytopenia induced by bortezomib.
Thromboembolism
Association between the CYP2C9 polymorphism and the drug metabolism phenotype.
Thrombophilia
Increased warfarin consumption and residual fibrin turnover in thrombotic patients with primary antiphospholipid syndrome.
Thrombophilia
Population study of thrombophilic markers and pharmacogenetic markers of warfarin prevalence in Bosnia and Herzegovina.
Thrombosis
Acute thrombosis of everolimus-eluting platinum chromium stent caused by impaired prasugrel metabolism due to cytochrome P450 enzyme 2B6*2 (C64T) polymorphism: a case report.
Thrombosis
Adverse Interaction between Capecitabine and Warfarin Resulting in Altered Coagulation Parameters: A Review of the Literature Starting from a Case Report.
Thrombosis
An evaluation of gene-gene interaction between the CYP2C9 and VKORC1 genotypes affecting the anticoagulant effect of phenprocoumon and acenocoumarol.
Thrombosis
Antiplatelet Therapy After Implantation of Drug-Eluting Stents: Duration, Resistance, Alternatives, and Management of Surgical Patients.
Thrombosis
Characterization of Patients With Angioscopically-Detected In-Stent Mural Thrombi.
Thrombosis
Characterization of patients with angioscopically-detected in-stent mural thrombi.
Thrombosis
Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention.
Thrombosis
Effect of polymorphisms in the cytochrome P450 CYP2C9 gene on warfarin anticoagulation.
Thrombosis
Effects of genetic factors to stent thrombosis due to clopidogrel resistance after coronary stent placement.
Thrombosis
Genotyping of CYP2C9 and VKORC1 polymorphisms predicts south Indian patients with deep vein thrombosis as fast metabolizers of warfarin/acenocoumarin.
Thrombosis
Global deregulation of ginseng products may be a safety hazard to warfarin takers: solid evidence of ginseng-warfarin interaction.
Thrombosis
Impact of Cytochrome P450 2C19 Reduced-Function Polymorphism on Lesions and Clinical Outcome in Japanese Patients After Drug-eluting Stent Implantation.
Thrombosis
Impact of cytochrome P450 2C19*2 polymorphism on intra-stent thrombus after drug-eluting stent implantation in Japanese patients receiving clopidogrel.
Thrombosis
Impact of cytochrome P450 2C19*2 polymorphism on intra-stent thrombus assessed by follow-up optical coherence tomography in Chinese patients receiving clopidogrel.
Thrombosis
Impact of genetic and clinical factors on warfarin therapy in patients early after heart valve replacement surgery.
Thrombosis
Incidence of Device-Related Thrombosis in Watchman Patients Undergoing a Genotype-Guided Antithrombotic Strategy.
Thrombosis
Polymorphisms of CYP2C9, VKORC1, MDR1, APOE and UGT1A1 genes and the therapeutic warfarin dose in Brazilian patients with thrombosis: a prospective cohort study.
Thrombosis
Prosthetic valve thrombosis - association of genetic polymorphisms of VKORC1, CYP2C9 and CYP4F2 genes.
Thrombosis
Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis.
Thrombosis
Relationship between cytochrome P450 2C19*2 polymorphism and stent thrombosis following percutaneous coronary intervention in Chinese patients receiving clopidogrel.
Thrombosis
The Influence of VKORC1 Polymorphisms on Warfarin Doses in Thai Patients with Deep Vein Thrombosis.
Thrombosis
Thrombotic genetic risk factors and warfarin pharmacogenetic variants in São Miguel's healthy population (Azores).
Thrombosis
[FREQUENCY OF POLYMORPHISM OF VKORC1 AND CYP2C9 GENES IN TWO REGIONS OF GEORGIA].
Thyroid Cancer, Papillary
Cyp24a1 attenuation limits progression of BrafV600E-induced papillary thyroid cancer cells and sensitizes them to BRAFV600E inhibitor PLX4720.
Thyroid Cancer, Papillary
Genetic polymorphism of CYP2D6 influences susceptibility to papillary thyroid cancer.
Thyroid Cancer, Papillary
Increased CYP24A1 expression is associated with BRAF(V600E) mutation and advanced stages in papillary thyroid carcinoma.
Thyroid Cancer, Papillary
Marked Increase in CYP24A1 Gene Expression in Human Papillary Thyroid Cancer.
Thyroid Cancer, Papillary
Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.
Thyroid Cancer, Papillary
Vitamin D-neutralizing CYP24A1 expression, oncogenic mutation states and histological findings of human papillary thyroid cancer.
Thyroid Carcinoma, Anaplastic
Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors.
Thyroid Diseases
Cytochrome P450 1A2 activity and incidence of thyroid disease and cancer after chronic or acute exposure to dioxins.
Thyroid Diseases
Genetic Polymorphisms of Pesticide-Metabolizing Enzymes and Transporters in Agricultural Workers and Thyroid Hormone Levels.
Thyroid Diseases
Unusual genetic variants associated with hypercholesterolemia in Argentina.
Thyroid Diseases
[Association of polymorph variants of CYP1A2 and CYP1A1 genes with reproductive and thyroid diseases in female workers of petrochemical industry].
Thyroid Diseases
[DIO2, TPO, CYP1A1 AND CYP1A2 gene polymorphism in women with thyroid disease].
Thyroid Neoplasms
Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors.
Thyroid Neoplasms
Association between CYP2E1 polymorphisms and risk of differentiated thyroid carcinoma.
Thyroid Neoplasms
Association between the CYP1A1 T3801C polymorphism and risk of cancer: evidence from 268 case-control studies.
Thyroid Neoplasms
CYP24A1 depletion facilitates the antitumor effect of vitamin D3 on thyroid cancer cells.
Thyroid Neoplasms
Gene Expression of CYP1A1 and its Possible Clinical Application in Thyroid Cancer Cases.
Thyroid Neoplasms
Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b5 Activity.
Thyroid Neoplasms
Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation.
Thyroid Neoplasms
Impaired Vitamin D activation and association with CYP24A1 haplotypes in differentiated thyroid carcinoma.
Thyroid Neoplasms
Impaired vitamin D activation and association with CYP24A1 haplotypes in differentiated thyroid carcinoma.
Thyroid Neoplasms
Increased CYP24A1 expression is associated with BRAF(V600E) mutation and advanced stages in papillary thyroid carcinoma.
Thyroid Neoplasms
Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.
Thyroid Neoplasms
Smoking and susceptibility to thyroid cancer: an inverse association with CYP1A1 allelic variants.
Thyroid Neoplasms
The Aryl Hydrocarbon Receptor Is Expressed in Thyroid Carcinoma and Appears to Mediate Epithelial-Mesenchymal-Transition.
Thyroid Nodule
Involvement of CYP1A1, GST, 72TP53 polymorphisms in the pathogenesis of thyroid nodules.
Thyroiditis
[DIO2, TPO, CYP1A1 AND CYP1A2 gene polymorphism in women with thyroid disease].
Thyroiditis, Autoimmune
[Association of polymorph variants of CYP1A2 and CYP1A1 genes with reproductive and thyroid diseases in female workers of petrochemical industry].
Thyroiditis, Autoimmune
[DIO2, TPO, CYP1A1 AND CYP1A2 gene polymorphism in women with thyroid disease].
Thyrotoxicosis
MATERNAL GRAVES DISEASE AND ABNORMAL CYP2D6 GENOTYPE WITH FETAL HYPERTHYROIDISM.
Tinnitus
Acute and Chronic Molecular Signatures and Associated Symptoms of Blast Exposure in Military Breachers.
Tonsillitis
Opioid-induced respiratory depression in paediatrics: a review of case reports.
Torsades de Pointes
Alzheimer's disease: beware of interactions with cholinesterase inhibitors.
Torsades de Pointes
CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system.
Torsades de Pointes
Drug-drug interactions and clinical considerations with co-administration of antiretrovirals and psychotropic drugs.
Torsades de Pointes
First-Degree Atrioventricular Block with Tachycardia from Paliperidone and Mirtazapine Overdose.
Torsades de Pointes
Major Cardiac-Psychiatric Drug-Drug Interactions: a Systematic Review of the Consistency of Drug Databases.
Torsades de Pointes
QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients.
Torsades de Pointes
Telithromycin: new preparation. A needless addition to the other macrolides.
Torsades de Pointes
Torsade de pointes resulting from the addition of droperidol to an existing cytochrome P450 drug interaction.
Torsades de Pointes
Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.
Torsades de Pointes
[Long QT and torsade de pointes in a patient with acquired human immunodeficiency virus infection in multitherapy with drugs affecting cytochrome P450]
Toxic Optic Neuropathy
Cytotoxic metabolite of acetaminophen, N-acetyl-p-benzoquinone imine, produces cataract in DBA2 mice.
Toxic Optic Neuropathy
Histocytological study on the possible mechanism of acetaminophen cataractogenesis in mouse eye.
Tremor
Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
Tremor
Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor.
Tremor
Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity induced by deltamethrin.
Tremor
Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9.
Tremor
Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice.
Trigeminal Neuralgia
Evaluation of the Pharmacokinetic Interaction Between the Voltage- and Use-Dependent Nav1.7 Channel Blocker Vixotrigine and Carbamazepine in Healthy Volunteers.
Triple Negative Breast Neoplasms
Anti-migration and anti-invasion effects of 2-hydroxy-6-tridecylbenzoic acid is associated with the enhancement of CYP1B1 expression through activating the AMPK signaling pathway in triple-negative breast cancer cells.
Triple Negative Breast Neoplasms
Prognostic value of using glucosylceramide synthase and cytochrome P450 family 1 subfamily A1 expression levels for patients with triple-negative breast cancer following neoadjuvant chemotherapy.
Triple Negative Breast Neoplasms
Single-nucleotide polymorphisms and mRNA expression of CYP1B1 influence treatment response in triple negative breast cancer patients undergoing chemotherapy.
Trismus
Efficacy of piroxicam for postoperative pain after lower third molar surgery associated with CYP2C8*3 and CYP2C9.
Tuberculosis
A comparison of steroid and lipid binding cytochrome P450s from Mycobacterium marinum and Mycobacterium tuberculosis.
Tuberculosis
Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes in a cohort of Peruvian tuberculosis patients.
Tuberculosis
Association of genetic polymorphisms of CYP2E1, NAT2, GST and SLCO1B1 with the risk of anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis.
Tuberculosis
Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450.
Tuberculosis
Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes.
Tuberculosis
Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis.
Tuberculosis
Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions.
Tuberculosis
Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis.
Tuberculosis
Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.
Tuberculosis
Cholesterol Analogs with Degradation-resistant Alkyl Side Chains Are Effective Mycobacterium tuberculosis Growth Inhibitors.
Tuberculosis
Cloning of the Recombinant Cytochrome P450 Cyp141 Protein of Mycobacterium tuberculosis as a Diagnostic Target and Vaccine Candidate.
Tuberculosis
Comparative assessment of metabolic enzyme levels in macrophage populations of the F344 rat.
Tuberculosis
Comparative study of the effects of anti-tuberculosis drugs and antiretroviral drugs on CYP3A4 and P-glycoprotein.
Tuberculosis
Computational finding of potential inhibitor for Cytochrome P450 Mono-oxygenases Enzyme of Mycobacterium tuberculosis.
Tuberculosis
Concerning P450 evolution: Structural Analyses Support Bacterial Origin of Sterol 14?-Demethylases.
Tuberculosis
Cross-linking of dicyclotyrosine by the cytochrome P450 enzyme CYP121 from Mycobacterium tuberculosis proceeds through a catalytic shunt pathway.
Tuberculosis
Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors.
Tuberculosis
Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode.
Tuberculosis
Crystallization and preliminary crystallographic analysis of a novel cytochrome P450 from Mycobacterium tuberculosis.
Tuberculosis
CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: towards deconvoluting enzymology of P450 systems in a human pathogen.
Tuberculosis
CYP2B6 18492T->C Polymorphism Compromises Efavirenz Concentration in Coinfected HIV and Tuberculosis Patients Carrying CYP2B6 Haplotype *1/*1.
Tuberculosis
CYP2C8 and CYP2E1 genetic variants increase risk of tuberculosis in northwest Chinese Han population.
Tuberculosis
CYP2E1 polymorphism, acetylator profiles and drug-induced liver injury incidence of Indonesian tuberculosis patients.
Tuberculosis
CYP2E1, GSTM1, and GSTT1 genetic polymorphisms and their associations with susceptibility to antituberculosis drug-induced liver injury in Thai tuberculosis patients.
Tuberculosis
CYP51-like gene of Mycobacterium tuberculosis actually encodes a P450 similar to eukaryotic CYP51.
Tuberculosis
cyp51A-based mechanism of azole resistance in Aspergillus fumigatus: Illustration by a new 3D Structural Model of Aspergillus fumigatus CYP51A protein.
Tuberculosis
Cytochrome CYP141: a new target for direct detection of Mycobacterium tuberculosis from clinical specimens.
Tuberculosis
Cytochrome P450 CYP2B6*6 distribution among Congolese individuals with HIV, Tuberculosis and Malaria infection.
Tuberculosis
Cytochromes P450: novel drug targets in the war against multidrug-resistant Mycobacterium tuberculosis.
Tuberculosis
Deletion of cyp125 Confers Increased Sensitivity to Azoles in Mycobacterium tuberculosis.
Tuberculosis
Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors.
Tuberculosis
Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics.
Tuberculosis
Distribution of allelic and genotypic frequencies of NAT2 and CYP2E1 variants in Moroccan population.
Tuberculosis
Effect of concomitantly administered rifampin on the pharmacokinetics and safety of atazanavir administered twice daily.
Tuberculosis
Effect of Rifampicin and CYP2B6 Genotype on Long-Term Efavirenz Autoinduction and Plasma Exposure in HIV Patients With or Without Tuberculosis.
Tuberculosis
Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients.
Tuberculosis
Electrochemistry of cytochromes p450: analysis of current-voltage characteristics of electrodes with immobilized cytochromes p450 for the screening of substrates and inhibitors.
Tuberculosis
Engineering a self-sufficient Mycobacterium tuberculosis CYP130 by gene fusion with the reductase-domain of CYP102A1 from Bacillus megaterium.
Tuberculosis
Establishing Dosing Recommendations for Efavirenz in HIV/TB-Coinfected Children Younger Than 3 Years.
Tuberculosis
Evaluation of cellular immunogenicity of recombinant cytochrome p450 cyp141 protein of Mycobacterium tuberculosis in human and mouse model.
Tuberculosis
Evaluation of Luminogenic Substrates as Probe Substrates for Bacterial Cytochrome P450 Enzymes: Application to Mycobacterium tuberculosis.
Tuberculosis
Evaluation of the drug interaction between rifabutin and efavirenz in patients with HIV infection and tuberculosis.
Tuberculosis
Expression and characterization of Mycobacterium tuberculosis CYP144: Common themes and lessons learned in the M. tuberculosis P450 enzyme family.
Tuberculosis
Expression and Purification of the Recombinant Cytochrome P450 CYP141 Protein of Mycobacterium Tuberculosis as a Diagnostic Tool and Vaccine Production.
Tuberculosis
Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis.
Tuberculosis
Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1.
Tuberculosis
Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?
Tuberculosis
Functional polymorphisms in CYP2C19 & CYP3A5 genes associated with decreased susceptibility for paediatric tuberculosis.
Tuberculosis
Genetic and Mass Spectrometric Tools for Elucidating the Physiological Function(s) of Cytochrome P450 Enzymes from Mycobacterium tuberculosis.
Tuberculosis
Genetic polymorphisms of cytochrome P450 and glutathione S-transferase associated with antituberculosis drug-induced hepatotoxicity in Chinese tuberculosis patients.
Tuberculosis
Genetic variation of ABCB1 (rs1128503, rs1045642) and CYP2E1 rs3813867 with the duration of tuberculosis therapy: a pilot study among tuberculosis patients in Indonesia.
Tuberculosis
Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis.
Tuberculosis
Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes.
Tuberculosis
Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines.
Tuberculosis
Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA.
Tuberculosis
Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners.
Tuberculosis
Mycobacterial cytochrome P450 125 (Cyp125) catalyzes the terminal hydroxylation of C27-steroids.
Tuberculosis
Mycobacterium tuberculosis CYP130: crystal structure, biophysical characterization, and interactions with antifungal azole drugs.
Tuberculosis
Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets.
Tuberculosis
Mycobacterium tuberculosis Rv1395 is a class III transcriptional regulator of the AraC family involved in cytochrome P450 regulation.
Tuberculosis
N-acetyltransferase and cytochrome P450 2E1 gene polymorphisms and susceptibility to antituberculosis drug hepatotoxicity in an Indian population.
Tuberculosis
NAT2 and CYP2E1 polymorphisms associated with antituberculosis drug-induced hepatotoxicity in Chinese patients.
Tuberculosis
New Application of 1,2,4-Triazole Derivatives as Antitubercular Agents. Structure, In Vitro Screening and Docking Studies.
Tuberculosis
Optimising plasma levels of clozapine during metabolic interactions: a review and case report with adjunct rifampicin treatment.
Tuberculosis
Pharmacokinetics of rifabutin during atazanavir/ritonavir co-administration in HIV-infected TB patients in India.
Tuberculosis
Photosystem I from plants as a bacterial cytochrome P450 surrogate electron donor: terminal hydroxylation of branched hydrocarbon chains
Tuberculosis
Photosystem I from plants as a bacterial cytochrome P450 surrogate electron donor: terminal hydroxylation of branched hydrocarbon chains.
Tuberculosis
Polymorphisms in CYP2E1, GSTM1 and GSTT1 and anti-tuberculosis drug-induced hepatotoxicity.
Tuberculosis
Polymorphisms of NAT2, CYP2E1, GST, and HLA related to drug-induced liver injury in indonesian tuberculosis patients.
Tuberculosis
Population Pharmacokinetics and Pharmacogenetics of Ethambutol in Adult Patients Coinfected with Tuberculosis and HIV.
Tuberculosis
Potential drug targets in the Mycobacterium tuberculosis cytochrome P450 system.
Tuberculosis
Probing Ligand Exchange in the P450 Enzyme CYP121 from Mycobacterium tuberculosis: Dynamic Equilibrium of the Distal Heme Ligand as a Function of pH and Temperature.
Tuberculosis
QM/MM study of the C-C coupling reaction mechanism of CYP121, an essential Cytochrome p450 of Mycobacterium tuberculosis.
Tuberculosis
Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.
Tuberculosis
Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide.
Tuberculosis
Relationship between CYP2E1 polymorphism and increase of ALT activity during therapy of patients with pulmonary tuberculosis.
Tuberculosis
Rifabutin for treating tuberculosis in solid organ transplant recipients: a retrospective observational study and literature review.
Tuberculosis
Risk factors of isoniazid-induced hepatotoxicity in Tunisian tuberculosis patients.
Tuberculosis
Safety, Tolerability, and Pharmacokinetic Interactions of the Antituberculous Agent TMC207 (Bedaquiline) With Efavirenz in Healthy Volunteers: AIDS Clinical Trials Group Study A5267.
Tuberculosis
Selective ?-1 oxidation of fatty acids by CYP147G1 from Mycobacterium marinum.
Tuberculosis
Serum Rifampicin Levels in Patients with Tuberculosis : Effect of P-Glycoprotein and CYP3A4 Blockers on its Absorption.
Tuberculosis
Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis.
Tuberculosis
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: Evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.
Tuberculosis
Structural biology and biochemistry of cytochrome P450 systems in Mycobacterium tuberculosis.
Tuberculosis
Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
Tuberculosis
Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis.
Tuberculosis
Structure, function and drug targeting in Mycobacterium tuberculosis cytochrome P450 systems.
Tuberculosis
Substrate analog studies of the ?-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1.
Tuberculosis
Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121: insights from biochemical studies and crystal structures.
Tuberculosis
Substrate-Assisted Hydroxylation and O-Demethylation in the Peroxidase-like Cytochrome P450 Enzyme CYP121.
Tuberculosis
The effect of isoniazid containing regimen on CYP2E1 during antituberculosis therapy.
Tuberculosis
The Mycobacterium tuberculosis cytochromes P450: physiology, biochemistry & molecular intervention.
Tuberculosis
The role of genetic polymorphisms in cytochrome P450 and effects of tuberculosis co-treatment on the predictive value of CYP2B6 SNPs and on efavirenz plasma levels in adult HIV patients.
Tuberculosis
The structure of Mycobacterium tuberculosis CYP125: Molecular basis for cholesterol binding in a P450 needed for host infection.
Tuberculosis
Therapeutic drug monitoring and pharmacogenetic study of HIV-infected ethnic chinese receiving efavirenz-containing antiretroviral therapy with or without rifampicin-based anti-tuberculous therapy.
Tuberculosis
[Genetic heterogeneity of cytochrome CYP51 in clinical strains of Mycobacterium tuberculosis]
Tuberculosis, Meningeal
Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G?T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis.
Tuberculosis, Pulmonary
Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis.
Tuberculosis, Pulmonary
Relationship between CYP2E1 polymorphism and increase of ALT activity during therapy of patients with pulmonary tuberculosis.
Tuberculosis, Pulmonary
[Insertional polymorphism of the CYP2E1 gene in infiltrative pulmonary tuberculosis in populations of Bashkortostan Republic]
Tumor Lysis Syndrome
Venetoclax plus cytochrome P450 inhibitors without ramp-up strategy led to low risk of tumor lysis syndrome in acute myeloid leukemia.
Turner Syndrome
Adrenal-cortex autoantibodies and steroid-producing cells autoantibodies in patients with Addison's disease: comparison of immunofluorescence and immunoprecipitation assays.
unspecific monooxygenase deficiency
A pilot study on risperidone metabolism: the role of cytochromes P450 2D6 and 3A.
unspecific monooxygenase deficiency
A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom).
unspecific monooxygenase deficiency
A Young Woman with Recurrent Gestational Hypercalcemia and Acute Pancreatitis Due to CYP24A1 Deficiency.
unspecific monooxygenase deficiency
Activity Levels of Tamoxifen Metabolites at the Estrogen Receptor and the Impact of Genetic Polymorphisms of Phase I and II Enzymes on Their Concentration Levels in Plasma.
unspecific monooxygenase deficiency
Acute toxicity of 3,4-methylenedioxymethamphetamine (MDMA) in Sprague-Dawley and Dark Agouti rats.
unspecific monooxygenase deficiency
Adverse drug reactions following nonresponse in a depressed patient with CYP2D6 deficiency and low CYP 3A4/5 activity.
unspecific monooxygenase deficiency
Characterization of a Novel CYP1A2 Knockout Rat Model Constructed by CRISPR/Cas9.
unspecific monooxygenase deficiency
Chinese patient with cerebrotendinous xanthomatosis confirmed by genetic testing: A case report and literature review.
unspecific monooxygenase deficiency
Clinical importance of genetic polymorphism of drug oxidation.
unspecific monooxygenase deficiency
Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.
unspecific monooxygenase deficiency
CYP1B1 deficiency ameliorates obesity and glucose intolerance induced by high fat diet in adult C57BL/6J mice.
unspecific monooxygenase deficiency
CYP1B1 deiciency ameliorates learning and memory deficits caused by high fat diet in mice.
unspecific monooxygenase deficiency
CYP24A1 deficiency causing persistent hypercalciuria in a stone former.
unspecific monooxygenase deficiency
CYP24A1 Mutations in a Cohort of Hypercalcemic Patients: Evidence for a Recessive Trait.
unspecific monooxygenase deficiency
CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24.
unspecific monooxygenase deficiency
CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects.
unspecific monooxygenase deficiency
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis.
unspecific monooxygenase deficiency
Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum.
unspecific monooxygenase deficiency
Cytochrome P450 2D6 deficiency and its clinical relevance in a patient treated with risperidone.
unspecific monooxygenase deficiency
Cytochrome P450 2E1 (CYP2E1) positively regulates lipid catabolism and induces browning in 3T3-L1 white adipocytes.
unspecific monooxygenase deficiency
Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[a]anthracene.
unspecific monooxygenase deficiency
Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism.
unspecific monooxygenase deficiency
Delayed resolution of amitriptyline toxicity secondary to CYP2D6 deficiency.
unspecific monooxygenase deficiency
Dextromethorphan poisoning in an adolescent with genetic cytochrome P450 CYP2D6 deficiency.
unspecific monooxygenase deficiency
Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol.
unspecific monooxygenase deficiency
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
unspecific monooxygenase deficiency
Distinct Binding of Cholesterol and 5beta-Cholestane-3alpha,7alpha,12alpha-triol to Cytochrome P450 27A1: Evidence from Modeling and Site-Directed Mutagenesis Studies.
unspecific monooxygenase deficiency
Drugs and Scaffold That Inhibit Cytochrome P450 27A1 In Vitro and In Vivo.
unspecific monooxygenase deficiency
Effect of CYP1A2 deficiency on heterocyclic amine DNA adduct levels in mice.
unspecific monooxygenase deficiency
Effect of CYP2D1 inhibition on the behavioural effects of d-amphetamine.
unspecific monooxygenase deficiency
Elucidation of the effects of the CYP1A2 deficiency polymorphism in the metabolism of 4-cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]pyrimidine-2-(1h)-one (YM-64227), a phosphodiesterase type 4 inhibitor, and its metabolites in dogs.
unspecific monooxygenase deficiency
Evidence for a role of sterol 27-hydroxylase in glucocorticoid metabolism in vivo.
unspecific monooxygenase deficiency
Female pseudohermaphroditism associated with a novel homozygous G-to-A (V370-to-M) substitution in the P-450 aromatase gene.
unspecific monooxygenase deficiency
Follicular fluid steroid and epidermal growth factor content, and in vitro estrogen release by granulosa-luteal cells from patients with polycystic ovaries in an IVF/ET program.
unspecific monooxygenase deficiency
Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County.
unspecific monooxygenase deficiency
Genetic polymorphism of cytochrome P450s in beagles: possible influence of CYP1A2 deficiency on toxicological evaluations.
unspecific monooxygenase deficiency
Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis.
unspecific monooxygenase deficiency
High Prevalence of Kidney Cysts in Patients With CYP24A1 Deficiency.
unspecific monooxygenase deficiency
High-dose venlafaxine treatment in a depressed patient with a genetic CYP2D6 deficiency.
unspecific monooxygenase deficiency
Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA.
unspecific monooxygenase deficiency
Influence of CYP2D6 genotype and medication on the sparteine metabolic ratio of psychiatric patients.
unspecific monooxygenase deficiency
Inhibition of CYP2D6 by quinidine and its effects on the metabolism of cilostazol.
unspecific monooxygenase deficiency
Intractable hypercalcaemia during pregnancy and the postpartum secondary to pathogenic variants in CYP24A1.
unspecific monooxygenase deficiency
Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells.
unspecific monooxygenase deficiency
Misdiagnosis of CTX due to propofol: The interference of total intravenous propofol anaesthesia with bile acid profiling.
unspecific monooxygenase deficiency
Neuroleptic malignant syndrome in an adolescent with CYP2D6 deficiency.
unspecific monooxygenase deficiency
Pilot study of the cytochrome P450-2D6 genotype in a psychiatric state hospital.
unspecific monooxygenase deficiency
Short communication. The effects of drinking and smoking on the CYP2D6 metabolic capacity.
unspecific monooxygenase deficiency
Targeted Next-Generation Sequencing in Diagnostic Approach to Monogenic Cholestatic Liver Disorders-Single-Center Experience.
unspecific monooxygenase deficiency
The canine CYP1A2 deficiency polymorphism dramatically affects the pharmacokinetics of 4-cyclohexyl-1-ethyl-7-methylpyrido[2,3-D]-pyrimidine-2-(1H)-one (YM-64227), a phosphodiesterase type 4 inhibitor.
unspecific monooxygenase deficiency
The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats.
unspecific monooxygenase deficiency
Toxicokinetic Interaction between Hepatic Disposition and Pulmonary Bioactivation of Inhaled Naphthalene Studied Using Cyp2abfgs-Null and CYP2A13/2F1-Humanized Mice with Deficient Hepatic Cytochrome P450 Activity.
unspecific monooxygenase deficiency
Warfarin therapy is feasible in CYP2C9*3 homozygous patients.
Uremia
Nitric oxide- and EDHF-mediated arteriolar tone in uremia is unaffected by selective inhibition of vascular cytochrome P450 2C9.
Urinary Bladder Neoplasms
Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.
Urinary Bladder Neoplasms
Aryl hydrocarbon hydroxylase inducibility is not altered in bladder cancer patients or their progeny.
Urinary Bladder Neoplasms
Association between polymorphisms in the biometabolism genes CYP1A1, GSTM1, GSTT1 and GSTP1 in bladder cancer.
Urinary Bladder Neoplasms
Association between the CYP1A2 rs762551 Polymorphism and Bladder Cancer Susceptibility: a Meta-Analysis Based on Case-Control Studies.
Urinary Bladder Neoplasms
Association of CYP2E1 gene polymorphisms with bladder cancer risk: A systematic review and meta-analysis.
Urinary Bladder Neoplasms
Association of genotypes of carcinogen-metabolizing enzymes and smoking status with bladder cancer in a Japanese population.
Urinary Bladder Neoplasms
Association of low CYP3A activity with p53 mutation and CYP2D6 activity with Rb mutation in human bladder cancer.
Urinary Bladder Neoplasms
Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China.
Urinary Bladder Neoplasms
Association of NR1I2, CYP3A5 and ABCB1 genetic polymorphisms with variability of temsirolimus pharmacokinetics and toxicity in patients with metastatic bladder cancer.
Urinary Bladder Neoplasms
Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.
Urinary Bladder Neoplasms
Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk.
Urinary Bladder Neoplasms
Comparison of CYP1A2 and NAT2 phenotypes between black and white smokers.
Urinary Bladder Neoplasms
Correlation of polymorphic expression of CYP2D6 mRNA in bladder mucosa and tumor tissue to in vivo debrisoquine hydroxylase activity.
Urinary Bladder Neoplasms
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms and bladder cancer risk in a Turkish population.
Urinary Bladder Neoplasms
CYP1A1 expression and organochlorine pesticides level in the etiology of bladder cancer in North Indian population.
Urinary Bladder Neoplasms
CYP1A2 polymorphisms, occupational and environmental exposures and risk of bladder cancer.
Urinary Bladder Neoplasms
CYP1A2, CYP2D6, GSTM1, GSTP1, and GSTT1 gene polymorphisms in patients with bladder cancer in a Turkish population.
Urinary Bladder Neoplasms
CYP1B1 gene polymorphisms correlate with an increased risk of urinary bladder cancer in India.
Urinary Bladder Neoplasms
CYP24A1 rs1570669 Variant Has a Protective Effect against Tumors of the Urinary System.
Urinary Bladder Neoplasms
CYP27A1 inhibits bladder cancer cells proliferation by regulating cholesterol homeostasis.
Urinary Bladder Neoplasms
CYP2E1 and NQO1 genotypes and bladder cancer risk in a Lebanese population.
Urinary Bladder Neoplasms
Cytochrome P450 isoenzyme mRNA expression pattern in human urinary bladder malignancies and normal urothelium.
Urinary Bladder Neoplasms
Cytochrome P4501A2 phenotype and bladder cancer risk: The shanghai bladder cancer study.
Urinary Bladder Neoplasms
Detection of CYP1A1 and GSTP1 gene polymorphisms in bladder cancer patients in a Turkish population using a polymerase chain reaction-restriction fragment length polymorphism method.
Urinary Bladder Neoplasms
Development Of A Three-Gene Prognostic Signature For Hepatitis B Virus Associated Hepatocellular Carcinoma Based On Integrated Transcriptomic Analysis.
Urinary Bladder Neoplasms
Expression of xenobiotic metabolizing enzymes in tumours of the urinary bladder.
Urinary Bladder Neoplasms
Expression profile of CYP1A1 and CYP1B1 enzymes in colon and bladder tumors.
Urinary Bladder Neoplasms
Frequencies of poor metabolizers of cytochrome P450 2C19 in esophagus cancer, stomach cancer, lung cancer and bladder cancer in Chinese population.
Urinary Bladder Neoplasms
Functional RsaI/PstI polymorphism in cytochrome P450 2E1 contributes to bladder cancer susceptibility: evidence from a meta-analysis.
Urinary Bladder Neoplasms
Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer.
Urinary Bladder Neoplasms
Genetic polymorphism of drug metabolizing enzymes (CYP2E1, GSTP1) and susceptibility to bladder cancer in North India.
Urinary Bladder Neoplasms
Genetic polymorphism of GSTM1, CYP2E1 and CYP2D6 in Egyptian bladder cancer patients.
Urinary Bladder Neoplasms
Genetic Polymorphisms in CYP1A1, CYP1B1, COMT, GSTP1 and NAT2 Genes and Association with Bladder Cancer Risk in a French Cohort.
Urinary Bladder Neoplasms
Genetic polymorphisms in the CYP1A1 and CYP1B1 genes and susceptibility to bladder cancer: a meta-analysis.
Urinary Bladder Neoplasms
Genetic Polymorphisms of CYP2A6 in a Case-Control Study on Bladder Cancer in Japanese Smokers.
Urinary Bladder Neoplasms
Genetic polymorphisms of CYP2D6, GSTM1, and GSTT1 genes and bladder cancer risk in North India.
Urinary Bladder Neoplasms
Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India.
Urinary Bladder Neoplasms
Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers.
Urinary Bladder Neoplasms
Genetic variants of the cytochrome P450 and glutathione S-transferase associated with risk of bladder cancer in a south-eastern Chinese population.
Urinary Bladder Neoplasms
Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.
Urinary Bladder Neoplasms
GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population.
Urinary Bladder Neoplasms
Lack of association between CYP1A1 polymorphisms and risk of bladder cancer: a meta-analysis.
Urinary Bladder Neoplasms
Metabolomic profiling reveals potential markers and bioprocesses altered in bladder cancer progression.
Urinary Bladder Neoplasms
Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2.
Urinary Bladder Neoplasms
Polymorphic CYP genes and disease predisposition--what have the studies shown so far?
Urinary Bladder Neoplasms
Polymorphisms in GSTT1, GSTZ1, and CYP2E1, Disinfection Byproducts, and Risk of Bladder Cancer in Spain.
Urinary Bladder Neoplasms
Polymorphisms in xenobiotic conjugation and disease predisposition.
Urinary Bladder Neoplasms
Polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes, CYP1A1 xenobiotic metabolism gene, and tobacco are associated with bladder cancer susceptibility in Tunisian population.
Urinary Bladder Neoplasms
Probing cytochrome P450 bioactivation and fluorescent properties with morpholinyl-tethered anthraquinones.
Urinary Bladder Neoplasms
Relationships Between CYP1A1 Genetic Polymorphisms and Bladder Cancer Risk: A Meta-Analysis.
Urinary Bladder Neoplasms
Retraction Note to: Genetic polymorphisms in the CYP1A1 and CYP1B1 genes and susceptibility to bladder cancer: a meta-analysis.
Urinary Bladder Neoplasms
Role of CYP1B1 gene polymorphisms in bladder cancer susceptibility.
Urinary Bladder Neoplasms
Study design and genetic susceptibility factors in the risk assessment of chemical carcinogens.
Urinary Bladder Neoplasms
The CYP1B1 Leu432Val polymorphism and risk of urinary system cancers.
Urinary Bladder Neoplasms
The CYP2D6 extensive metabolizer genotype is associated with increased risk for bladder cancer.
Urinary Bladder Neoplasms
The effect of CYP1A1 and GSTM1 gene polymorphisms in bladder cancer development in a Turkish population.
Urinary Bladder Neoplasms
The relationship between polymorphisms of xenobiotic metabolizing enzymes and susceptibility to cancer.
Urinary Bladder Neoplasms
Use of analgesics and nonsteroidal anti-inflammatory drugs, genetic predisposition, and bladder cancer risk in Spain.
Urinary Bladder Neoplasms
Variation in enzymes of arylamine procarcinogen biotransformation among bladder cancer patients and control subjects.
Urinary Bladder Neoplasms
[Steroid and xenobiotic receptor (SXR), multidrug resistance gene (MDR1) and GSTs, SULTs and CYP polymorphism expression in invasive bladder cancer, analysis of their expression and correlation with other prognostic factors]
Urinary Bladder, Overactive
Assessment of inhibitory effects on major human cytochrome P450 enzymes by spasmolytics used in the treatment of overactive bladder syndrome.
Urinary Bladder, Overactive
Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective ?(3)-adrenoceptor agonist.
Urinary Bladder, Overactive
In vitro inhibition and induction of human cytochrome P450 enzymes by mirabegron, a potent and selective ?3-adrenoceptor agonist.
Urinary Bladder, Overactive
Overactive Bladder Prescribing Considerations: The Role of Polypharmacy, Anticholinergic Burden, and CYP2D6 Drug?Drug Interactions.
Urinary Calculi
Ultra-rare renal diseases diagnosed with whole-exome sequencing: Utility in diagnosis and management.
Urinary Incontinence
Effect of propiverine on cytochrome P450 enzymes: a cocktail interaction study in healthy volunteers.
Urinary Incontinence
Genetic susceptibility to urinary incontinence: implication of polymorphisms of androgen and oestrogen pathways.
Urinary Incontinence, Urge
Inhibitory effects of trospium chloride on cytochrome P450 enzymes in human liver microsomes.
Urinary Tract Infections
Cytochrome P450 (CYP2D6) Genotype is Associated with Elevated Systolic Blood Pressure in Preterm Infants after Discharge from the Neonatal Intensive Care Unit.
Urinary Tract Infections
Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study.
Urogenital Neoplasms
Pharmacokinetics and pharmacodynamics of paclitaxel with carboplatin or gemcitabine, and effects of CYP3A5 and MDR1 polymorphisms in patients with urogenital cancers.
Urolithiasis
Three Sisters With Heterozygous Gene Variants of CYP24A1: Maternal Hypercalcemia, New-Onset Hypertension, and Neonatal Hypoglycemia.
Urologic Neoplasms
Cytochrome P450 2E1 RsaI/PstI polymorphism is associated with urologic cancer risk: evidence from a meta-analysis.
Urticaria
Disruption of quercetin metabolism by fungicide affects energy production in honey bees (Apis mellifera).
Urticaria
Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria.
Uterine Cervical Neoplasms
Allelic variations in CYP2D6 gene and susceptibility to cervical cancer.
Uterine Cervical Neoplasms
Analysis of CYP1A1 and COMT polymorphisms in women with cervical cancer.
Uterine Cervical Neoplasms
Anti-estrogenic activities of indole-3-carbinol in cervical cells: implication for prevention of cervical cancer.
Uterine Cervical Neoplasms
Association of CYP1A1 gene variants rs4646903 (T>C) and rs1048943 (A>G) with cervical cancer in a North Indian population.
Uterine Cervical Neoplasms
Cervical cancer and CYP2E1 polymorphisms: implications for molecular epidemiology.
Uterine Cervical Neoplasms
CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.
Uterine Cervical Neoplasms
CYP1A1 gene polymorphism as a risk factor for cervical intraepithelial neoplasia and invasive cervical cancer.
Uterine Cervical Neoplasms
CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis.
Uterine Cervical Neoplasms
CYP1A1 Ile462Val Polymorphism as a Risk Factor in Cervical Cancer Development in the Polish Population.
Uterine Cervical Neoplasms
CYP1A1 MspI Polymorphism and Cervical Carcinoma Risk in the Multi-Ethnic Population of Malaysia: a Case-Control Study.
Uterine Cervical Neoplasms
CYP1B1 C4326G polymorphism and susceptibility to cervical cancer in Chinese Han women.
Uterine Cervical Neoplasms
Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and cervical cancer risk: a meta-analysis.
Uterine Cervical Neoplasms
Cytochrome P450 1A1 gene polymorphisms and cervical cancer risk: A systematic review and meta-analysis.
Uterine Cervical Neoplasms
Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer.
Uterine Cervical Neoplasms
Genetic Polymorphisms of the Human Cytochrome P450 1A1 (CYP1A1) and Cervical Cancer Susceptibility among Northeast Thai Women.
Uterine Cervical Neoplasms
Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: associations with tumor progression, age and human papillomavirus infection.
Uterine Cervical Neoplasms
HLA genes and other candidate genes involved in susceptibility for (pre)neoplastic cervical disease.
Uterine Cervical Neoplasms
Meta-Analysis of Polymorphic Variants Conferring Genetic Risk to Cervical Cancer in Indian Women Supports CYP1A1
as an Important Associated Locus
Uterine Cervical Neoplasms
Polymorphism of CYP1A1 gene variants rs4646903 and rs1048943 relation to the incidence of cervical cancer in Chhattisgarh.
Uterine Cervical Neoplasms
Polymorphisms and haplotypes of TLR4, TLR9 and CYP1A1 genes possibly interfere with high-risk human papillomavirus infection and cervical cancer susceptibility in Jharkhand, India.
Uterine Cervical Neoplasms
Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium.
Uterine Cervical Neoplasms
Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking.
Uterine Cervical Neoplasms
Significant association between CYP1A1 T3801C polymorphism and cervical neoplasia risk: a systematic review and meta-analysis.
Uterine Cervical Neoplasms
The Association of CYP1A1 Gene With Cervical Cancer and Additional SNP-SNP Interaction in Chinese Women.
Uterine Cervical Neoplasms
The risk of developing cervical cancer in Mexican women is associated to CYP1A1 MspI polymorphism.
Vaccinia
Catalytic properties of the human cytochrome P450 2E1 produced by cDNA expression in mammalian cells.
Vaccinia
cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver.
Vaccinia
Characterization of the human cytochrome P450 isozymes responsible for styrene metabolism.
Vaccinia
Chlorzoxazone metabolism by winter flounder liver microsomes: evidence for existence of a CYP2E1-like isoform in teleosts.
Vaccinia
Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system.
Vaccinia
Cytochrome P450 2A1, 2E1, and 2C9 cDNA-expression by insect cells and partial purification using hydrophobic chromatography.
Vaccinia
Enzyme-kinetic and immunochemical characteristics of mouse cDNA-expressed, microsomal, and purified CYP1A1 and CYP1A2.
Vaccinia
Estradiol metabolism by complementary deoxyribonucleic acid-expressed human cytochrome P450s.
Vaccinia
Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.
Vaccinia
Human cDNA-expressed cytochrome P450 IA2: mutagen activation and substrate specificity.
Vaccinia
Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily.
Vaccinia
Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype.
Vaccinia
Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism.
Vaccinia
Metabolic activation of the pneumotoxin, 3-methylindole, by vaccinia-expressed cytochrome P450s.
Vaccinia
Molecular biology of human xenobiotic-metabolizing cytochromes P450: role of vaccinia virus cDNA expression in evaluating catalytic function.
Vaccinia
Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline by complementary DNA-expressed human liver P-450.
Vaccinia
Oxidative metabolism of bunitrolol by complementary DNA-expressed human cytochrome P450 isozymes in a human hepatoma cell line (Hep G2) using recombinant vaccinia virus.
Vaccinia
Role of cytochrome P450 IA2 in acetanilide 4-hydroxylation as determined with cDNA expression and monoclonal antibodies.
Vaccinia
Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8.
Vaccinia
Selective suppression of the catalytic activity of cDNA-expressed cytochrome P4502B1 toward polycyclic hydrocarbons in the microsomal membrane: modification of this effect by specific amino acid substitutions.
Vaccinia
Specificity of cDNA-expressed human and rodent cytochrome P450s in the oxidative metabolism of the potent carcinogen 7,12-dimethylbenz[a]anthracene.
Vaccinia
Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes.
Vaccinia
Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s.
Varicose Veins
Cytochromes P450 are differently expressed in normal and varicose human saphenous veins: linkage with varicosis.
Varicose Veins
Influence of CYP2D6 and ?2-adrenergic receptor gene polymorphisms on the hemodynamic response to propranolol in Chinese Han patients with cirrhosis.
Vascular Calcification
CYP24A1 and KL polymorphisms are associated with the extent of vascular calcification but do not improve prediction of cardiovascular events.
Vascular Diseases
Common polymorphisms in CYP2C9, subclinical atherosclerosis and risk of ischemic vascular disease in 52,000 individuals.
Vascular Diseases
Cytochrome P450 1B1 and 2C9 Genotypes and Risk of Ischemic Vascular Disease, Cancer, and Chronic Obstructive Pulmonary Disease.
Vascular Diseases
Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes.
Vascular Diseases
Role of the Aryl Hydrocarbon Receptor/ARNT/Cytochrome P450 System in Pulmonary Vascular Diseases.
Vascular Malformations
2,3,7,8-Tetrachlorodibenzo-p-dioxin exposure disrupts development of the visceral and ocular vasculature.
Vascular System Injuries
Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury: therapy through LOX-1 receptor antagonism?
Vasculitis
Cyclophosphamide treatment-induced leukopenia rates in ANCA-associated vasculitis are influenced by variant CYP450 2C9 genotypes.
Vasculitis
The pharmacogenomic association of Fc? receptors and cytochrome p450 enzymes and response to treatment with rituximab or cyclophosphamide in Anti-Neutrophil Cytoplasmic Antibody-Associated vasculitis.
Vasculitis
Use of Enantiomeric Bupropion and Hydroxybupropion to Assess CYP2B6 Activity in Glomerular Kidney Diseases.
Venous Thromboembolism
A regression model to predict warfarin dose from clinical variables and polymorphisms in CYP2C9, CYP4F2, and VKORC1: Derivation in a sample with predominantly a history of venous thromboembolism.
Venous Thromboembolism
Efficiency and effectiveness of the use of an acenocoumarol pharmacogenetic dosing algorithm versus usual care in patients with venous thromboembolic disease initiating oral anticoagulation: study protocol for a randomized controlled trial.
Venous Thromboembolism
Prediction of stable acenocoumarol dose by a pharmacogenetic algorithm.
Venous Thromboembolism
Synergism between oral estrogen therapy and cytochrome P450 3A5*1 allele on the risk of venous thromboembolism among postmenopausal women.
Venous Thromboembolism
VKORC1 and CYP2C9 polymorphisms are associated with warfarin dose requirements in Turkish patients.
Venous Thrombosis
Effect of polymorphisms in the cytochrome P450 CYP2C9 gene on warfarin anticoagulation.
Venous Thrombosis
Genotyping of CYP2C9 and VKORC1 polymorphisms predicts south Indian patients with deep vein thrombosis as fast metabolizers of warfarin/acenocoumarin.
Venous Thrombosis
Influence of CYP2C9 polymorphism and phenytoin co-administration on acenocoumarol dose in patients with cerebral venous thrombosis.
Venous Thrombosis
Regulation of the f11, klkb1, cyp4v3 gene cluster in livers of metabolically challenged mice.
Venous Thrombosis
The Influence of VKORC1 Polymorphisms on Warfarin Doses in Thai Patients with Deep Vein Thrombosis.
Venous Thrombosis
VKORC1 and CYP2C9 genotypes in Egyptian patients with warfarin resistance.
Vesicular Stomatitis
Molecular basis for the transport of cytochrome P450 2E1 to the plasma membrane.
Virus Diseases
Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection.
Virus Diseases
Changes of antipyrine pharmacokinetics during influenza and after administration of interferon-alpha and -beta.
Virus Diseases
CYP24A1 genetic variants in the vitamin D metabolic pathway are involved in the outcomes of hepatitis C virus infection among high-risk Chinese population.
Virus Diseases
Cytochrome P450 2A6 meets P450 2D6: an enigma of viral infections and autoimmunity.
Virus Diseases
Cytochrome P450 2A6: a new hepatic autoantigen in patients with chronic hepatitis C virus infection.
Virus Diseases
Cytochrome P450 down-regulation by serum from humans with a viral infection and from rabbits with an inflammatory reaction.
Virus Diseases
Cytochrome P450 inactivation by serum from humans with a viral infection and serum from rabbits with a turpentine-induced inflammation: the role of cytokines.
Virus Diseases
Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients.
Virus Diseases
Distribution of Polymorphisms in Cytochrome P450 2B6, Histocompatibility Complex P5, Chemokine Coreceptor 5, and Interleukin 28B Genes in Inhabitants from the Central Area of Argentina.
Virus Diseases
Down-regulation of the hepatic cytochrome P450 by an acute inflammatory reaction: implication of mediators in human and animal serum and in the liver.
Virus Diseases
Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.
Virus Diseases
Effect of immobilization, cold and cold-restraint stress on liver monooxygenase activity and lipid peroxidation of influenza virus-infected mice.
Virus Diseases
Effect of low-dose ritonavir (100 mg twice daily) on the activity of cytochrome P450 2D6 in healthy volunteers.
Virus Diseases
Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China.
Virus Diseases
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Virus Diseases
Impact of CYP2R1, CYP27A1 and CYP27B1 genetic polymorphisms controlling vitamin D metabolism on susceptibility to hepatitis C virus infection in a high-risk Chinese population.
Virus Diseases
Inflammation-induced phenoconversion of polymorphic drug metabolizing enzymes: hypothesis with implications for personalized medicine.
Virus Diseases
Influence of Cytochrome P450 3A5 Polymorphisms on Viral Infection Incidence in Kidney Transplant Patients Treated With Tacrolimus.
Virus Diseases
Interleukin-1beta, interleukin-6, tumour necrosis factor-alpha and interferon-gamma released by a viral infection and an aseptic inflammation reduce CYP1A1, 1A2 and 3A6 expression in rabbit hepatocytes.
Virus Diseases
Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection.
Virus Diseases
Modulatory effect of hyperthermia on hepatic microsomal cytochrome P450 in mice.
Virus Diseases
RAPID DEVELOPMENT OF IATROGENIC CUSHING SYNDROME IN A PATIENT ON RITONAVIR: THE ADVERSE METABOLIC CONSEQUENCE OF TOPICAL STEROID USE.
Virus Diseases
Role of Cytochrome P450 2B6 Pharmacogenomics in Determining Efavirenz-Mediated Central Nervous System Toxicity, Treatment Outcomes, and Dosage Adjustments in Patients with Human Immunodeficiency Virus Infection.
Virus Diseases
Role of reactive oxygen intermediates in the decrease of hepatic cytochrome P450 activity by serum of humans and rabbits with an acute inflammatory reaction.
Virus Diseases
Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.
Virus Diseases
Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine.
Virus Diseases
Signal transduction pathways implicated in the decrease in CYP1A1, 1A2 and 3A6 activity produced by serum from rabbits and humans with an inflammatory reaction.
Virus Diseases
[HEV capsid protein interacts with CYP 2A6 and decreases its coumarin 7-hydroxylation activity]
Virus Diseases
[Long QT and torsade de pointes in a patient with acquired human immunodeficiency virus infection in multitherapy with drugs affecting cytochrome P450]
Virus Diseases
[Progress in the study of heterogeneous nuclear ribonucleoprotein and its relation with diseases]
Vitamin A Deficiency
Cyp1b1 deletion and retinol deficiency coordinately suppress mouse liver lipogenic genes and hepcidin expression during post-natal development.
Vitamin A Deficiency
Pretranslational down regulation of cytochrome P450 2C11 in vitamin A-deficient male rat liver: prevention by dietary inclusion of retinoic acid.
Vitamin A Deficiency
Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status.
Vitamin A Deficiency
Restoration of cytochrome P450 2C11 in vitamin A-deficient rat liver by exogenous androgen.
Vitamin A Deficiency
Role of signalling systems in the effects of dietary factors on the expression of mammalian CYPs.
Vitamin A Deficiency
Suppression of the constitutive microsomal cytochrome P450 2C11 in male rat liver during dietary vitamin A deficiency.
Vitamin A Deficiency
The differential effects of chemical carcinogens on vitamin A status and on microsomal drug metabolism in normal and vitamin A-deficient rats.
Vitamin A Deficiency
Vitamin A levels in regenerating rat liver. Effects on microsomal drug metabolism.
Vitamin B 6 Deficiency
Pyridoxine deficiency modulates benzene inhalation-induced hematotoxicity associated with hepatic CYP2E1 activity in B6C3F1 mice.
Vitamin B 6 Deficiency
The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1 mice.
Vitamin D Deficiency
A theoretical insight to understand the molecular mechanism of dual target ligand CTA-018 in the chronic kidney disease pathogenesis.
Vitamin D Deficiency
Assessing vitamin D related genetic variants, status, and influence factors in pregnant women in Eastern and Central China.
Vitamin D Deficiency
Associations of CYP24A1 Copy Number Variation with Vitamin D Deficiency and Insulin Secretion.
Vitamin D Deficiency
Characterization of an animal model of pregnancy-induced vitamin D deficiency due to metabolic gene dysregulation.
Vitamin D Deficiency
Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D(3) through CYP3A4 induction in vitro and in vivo: Implications for drug-induced osteomalacia.
Vitamin D Deficiency
Osteomalacia in an HIV-infected man receiving rifabutin, a cytochrome P450 enzyme inducer: a case report.
Vitamin D Deficiency
Paradoxical deterioration in seizure control due to anticonvulsant-induced hypocalcaemia.
Vitamin D Deficiency
Simultaneous measurement of 25(OH)-vitamin D and 24,25(OH)2-vitamin D to define cut-offs for CYP24A1 mutation and vitamin D deficiency in a population of 1200 young subjects.
Vitamin D Deficiency
Vitamin D Deficiency Attenuates Acute Alcohol-Induced Hepatic Lipid Accumulation in Mice.
Vitamin D Deficiency
Vitamin D pathway gene polymorphisms influenced vitamin D level among pregnant women.
Vitamin D Deficiency
Vitamin D Status in Russian Children and Adolescents: Contribution of Genetic and Exogenous Factors.
vitamin d3 24-hydroxylase deficiency
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
Vitamin E Deficiency
Effects of vitamin E deficiency on hepatic microsomal cytochrome P450 and phase II enzymes in male and female rats.
Vitamin E Deficiency
Increasing lipid peroxidation by vitamin E deficiency does not augment adriamycin-induced inhibition of hepatic drug metabolism.
Vitamin E Deficiency
Vitamin E deficiency accelerates nitrate tolerance via a decrease in cardiac P450 expression and increased oxidative stress.
Vitamin K Deficiency
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin or 2,2',4,4',5,5'-hexachlorobiphenyl on vitamin K-dependent blood coagulation in male and female WAG/Rij-rats.
Vulvar Neoplasms
Correspondence re: C. Chen et al., CYP2D6 genotype and the incidence of anal and vulvar cancer. Cancer Epidemiol. Biomark. Prev., 8: 317-321, 1999.
Wasting Syndrome
Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.
Wasting Syndrome
Restoration of Dioxin-Induced Damage to Fetal Steroidogenesis and Gonadotropin Formation by Maternal Co-Treatment with ?-Lipoic Acid.
Werner Syndrome
Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver.
Whooping Cough
Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytes.
Whooping Cough
Testosterone rapidly increases Ca(2+)-activated K(+) currents causing hyperpolarization in human coronary artery endothelial cells.
Williams Syndrome
Differential diagnosis of vitamin D-related hypercalcemia using serum vitamin D metabolite profiling.
Wilms Tumor
Exclusion of Wilms tumour (WT1b) and ovarian cytochrome P450 aromatase (CYP19A1) as candidates for sex determination genes in Nile tilapia (Oreochromis niloticus).
Wilms Tumor
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
Wilms Tumor
New frontiers on the molecular underpinnings of hypospadias according to severity.
Wilms Tumor
Novel role for the orphan nuclear receptor Dax1 in embryogenesis, different from steroidogenesis.
Wilms Tumor
WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells.
Xanthomatosis
A case of Cerebrotendinous Xanthomatosis with spinal cord involvement and without tendon xanthomas: identification of a new mutation of the CYP27A1 gene.
Xanthomatosis
Bilateral Femoral Neck Fractures in Cerebrotendinous Xanthomatosis Treated by Hip Arthroplasties: The First Case Report and Literature Review.
Xanthomatosis
Cerebrotendinous xanthomatosis, a metabolic disease with different neurological signs: two case reports.
Xanthomatosis
Chinese patient with cerebrotendinous xanthomatosis confirmed by genetic testing: A case report and literature review.
Xanthomatosis
Clinical and genetic characteristics of Chinese patients with cerebrotendinous xanthomatosis.
Xanthomatosis
Elimination of endoplasmic reticulum stress and cardiovascular, type 2 diabetic, and other metabolic diseases.
Xanthomatosis
Familial variability of cerebrotendinous xanthomatosis lacking typical biochemical findings.
Xanthomatosis
On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation.
Xanthomatosis
Structure-function analysis of CYP27B1 and CYP27A1. Studies on mutants from patients with vitamin D-dependent rickets type I (VDDR-I) and cerebrotendinous xanthomatosis (CTX).
Xanthomatosis, Cerebrotendinous
A case of cerebrotendinous xanthomatosis mimicking the clinical phenotype of mitochondrial disease with a novel frame-shift mutation (c. 43_44 delGG) in CYP27A1 gene exon 1.
Xanthomatosis, Cerebrotendinous
A case of cerebrotendinous xanthomatosis presenting with epilepsy as an initial symptom with a novel V413D mutation in the CYP27A1 gene.
Xanthomatosis, Cerebrotendinous
A case of Cerebrotendinous Xanthomatosis with spinal cord involvement and without tendon xanthomas: identification of a new mutation of the CYP27A1 gene.
Xanthomatosis, Cerebrotendinous
A Case of Late-onset Cerebrotendinous Xanthomatosis with a Novel Mutation in the CYP27A1 Gene.
Xanthomatosis, Cerebrotendinous
A compound heterozygous mutation of CYP27A1 gene in a Taiwanese patient with cerebrotendinous xanthomatosis.
Xanthomatosis, Cerebrotendinous
A Late-onset and Relatively Rapidly Progressive Case of Pure Spinal Form Cerebrotendinous Xanthomatosis with a Novel Mutation in the CYP27A1 Gene.
Xanthomatosis, Cerebrotendinous
A novel frameshift mutation in the sterol 27-hydroxylase gene in an Egyptian family with cerebrotendinous xanthomatosis without cataract.
Xanthomatosis, Cerebrotendinous
A novel mutation in the CYP27A1 gene in a family with cerebrotendinous xanthomatosis.
Xanthomatosis, Cerebrotendinous
Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma.
Xanthomatosis, Cerebrotendinous
Apparent underdiagnosis of Cerebrotendinous Xanthomatosis revealed by analysis of ~60,000 human exomes.
Xanthomatosis, Cerebrotendinous
Autism spectrum disorder: an early and frequent feature in cerebrotendinous xanthomatosis.
Xanthomatosis, Cerebrotendinous
Bilateral Femoral Neck Fractures in Cerebrotendinous Xanthomatosis Treated by Hip Arthroplasties: The First Case Report and Literature Review.
Xanthomatosis, Cerebrotendinous
Brain diffusion tensor imaging changes in cerebrotendinous xanthomatosis reversed with treatment.
Xanthomatosis, Cerebrotendinous
c.1263+1G>A Is a Latent Hotspot for CYP27A1 Mutations in Chinese Patients With Cerebrotendinous Xanthomatosis.
Xanthomatosis, Cerebrotendinous
Cerebrotendinous Xanthomatosis ataxia responsive to CDCA and Riluzole.
Xanthomatosis, Cerebrotendinous
Cerebrotendinous xanthomatosis in Spain: clinical, prognostic, and genetic survey.
Xanthomatosis, Cerebrotendinous
Cerebrotendinous xanthomatosis with the c.379C>T (p.R127W) mutation in the CYP27A1 gene associated with premature age-associated limbic tauopathy.
Xanthomatosis, Cerebrotendinous
Cerebrotendinous xanthomatosis, a metabolic disease with different neurological signs: two case reports.
Xanthomatosis, Cerebrotendinous
Cerebrotendinous xanthomatosis: a comprehensive review of pathogenesis, clinical manifestations, diagnosis, and management.
Xanthomatosis, Cerebrotendinous
Cerebrotendinous Xanthomatosis: Molecular Pathogenesis, Clinical Spectrum, Diagnosis, and Disease-Modifying Treatments.
Xanthomatosis, Cerebrotendinous
Cerebrotendinous xanthomatosis: Possibility of founder mutation in CYP27A1 gene (c.526delG) in Eastern Indian and Surinamese population.
Xanthomatosis, Cerebrotendinous
Cerebrotendinous xanthomatosis: recurrence of the CYP27A1 mutation p.Arg479Cys in Sardinia.
Xanthomatosis, Cerebrotendinous
Cholestasis as a dominating symptom of patients with CYP27A1 mutations: An analysis of 17 Chinese infants.
Xanthomatosis, Cerebrotendinous
Cholestenoic acids regulate motor neuron survival via liver X receptors.
Xanthomatosis, Cerebrotendinous
Clinical and Genetic Characteristics of Splicing Variant in CYP27A1 in an Iranian Family with Cerebrotendinous Xanthomatosis.
Xanthomatosis, Cerebrotendinous
Clinical and molecular diagnosis of cerebrotendinous xanthomatosis with a review of the mutations in the CYP27A1 gene.
Xanthomatosis, Cerebrotendinous
Clinical and molecular genetic features of cerebrotendinous xanthomatosis in Taiwan: Report of a novel CYP27A1 mutation and literature review.
Xanthomatosis, Cerebrotendinous
Clinical and molecular genetic features of cerebrotendinous xanthomatosis patients in Chinese families.
Xanthomatosis, Cerebrotendinous
Clinical and radiological findings of a cerebrotendinous xanthomatosis patient with a novel p.A335V mutation in the CYP27A1 gene.
Xanthomatosis, Cerebrotendinous
Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum.
Xanthomatosis, Cerebrotendinous
Cytochrome P450s in the synthesis of cholesterol and bile acids - from mouse models to human diseases.
Xanthomatosis, Cerebrotendinous
Distinct Binding of Cholesterol and 5beta-Cholestane-3alpha,7alpha,12alpha-triol to Cytochrome P450 27A1: Evidence from Modeling and Site-Directed Mutagenesis Studies.
Xanthomatosis, Cerebrotendinous
Epidemiology, diagnosis, and treatment of cerebrotendinous xanthomatosis (CTX).
Xanthomatosis, Cerebrotendinous
Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis.
Xanthomatosis, Cerebrotendinous
Evidence for a role of sterol 27-hydroxylase in glucocorticoid metabolism in vivo.
Xanthomatosis, Cerebrotendinous
Familial variability of cerebrotendinous xanthomatosis lacking typical biochemical findings.
Xanthomatosis, Cerebrotendinous
Gene supplementation of CYP27A1 in the liver restores bile acid metabolism in a mouse model of cerebrotendinous xanthomatosis.
Xanthomatosis, Cerebrotendinous
Identification of 7?,24-dihydroxy-3-oxocholest-4-en-26-oic and 7?,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma.
Xanthomatosis, Cerebrotendinous
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.
Xanthomatosis, Cerebrotendinous
Juvenile Cataract Morphology in 3 Siblings Not Yet Diagnosed with Cerebrotendinous Xanthomatosis.
Xanthomatosis, Cerebrotendinous
Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS.
Xanthomatosis, Cerebrotendinous
Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis.
Xanthomatosis, Cerebrotendinous
Mutation in CYP27A1 identified in family with coronary artery disease.
Xanthomatosis, Cerebrotendinous
NGS-Based Diagnosis of Treatable Neurogenetic Disorders in Adults: Opportunities and Challenges.
Xanthomatosis, Cerebrotendinous
Novel splice-affecting variants in CYP27A1 gene in two Chilean patients with Cerebrotendinous Xanthomatosis.
Xanthomatosis, Cerebrotendinous
Optic Neuropathy with Features Suggestive of Optic Neuritis in Cerebrotendinous Xanthomatosis.
Xanthomatosis, Cerebrotendinous
Patients with cerebrotendinous xanthomatosis diagnosed with diverse multisystem involvement.
Xanthomatosis, Cerebrotendinous
Patients with Lately Diagnosed Cerebrotendinous Xanthomatosis.
Xanthomatosis, Cerebrotendinous
Prevalence of Cerebrotendinous Xanthomatosis Among Patients Diagnosed With Acquired Juvenile-Onset Idiopathic Bilateral Cataracts.
Xanthomatosis, Cerebrotendinous
Progressive Myoclonic Epilepsy'-like presentation of Cerebrotendinous Xanthomatosis in an Indian Family with A Novel C.646+1G>A Splice Site Mutation.
Xanthomatosis, Cerebrotendinous
Prominent Tendon Xanthomas and Abdominal Aortic Aneurysm Associated with Cerebrotendinous Xanthomatosis Identified Using Whole Exome Sequencing.
Xanthomatosis, Cerebrotendinous
Spinal form cerebrotendinous xanthomatosis patient with long spinal cord lesion.
Xanthomatosis, Cerebrotendinous
Sterol 27-Hydroxylase Deficiency as a Cause of Neonatal Cholestasis: Report of 2 Cases and Review of the Literature.
Xanthomatosis, Cerebrotendinous
Structure-function analysis of CYP27B1 and CYP27A1. Studies on mutants from patients with vitamin D-dependent rickets type I (VDDR-I) and cerebrotendinous xanthomatosis (CTX).
Xanthomatosis, Cerebrotendinous
The first cerebrotendinous xanthomatosis family from Argentina: a new mutation in CYP27A1 gene.
Xanthomatosis, Cerebrotendinous
The role of dentate nuclei in human oculomotor control: insights from cerebrotendinous xanthomatosis.
Xanthomatosis, Cerebrotendinous
The wide spectrum of cerebrotendinous xanthomatosis: Case report of a rare but treatable disease.
Xanthomatosis, Cerebrotendinous
Three siblings with Cerebrotendinous Xanthomatosis: A novel mutation in the CYP27A1 gene.
Xanthomatosis, Cerebrotendinous
Toward newborn screening of cerebrotendinous xanthomatosis: results of a biomarker research study using 32,000 newborn dried blood spots.
Xanthomatosis, Cerebrotendinous
Unique case of cerebrotendinous xanthomatosis revisited: All the mutations responsible for this disease are present in the CYP27A1 gene.
Xanthomatosis, Cerebrotendinous
Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase.
Xanthomatosis, Cerebrotendinous
[Cerebrotendinous xanthomatosis is a rare disorder, which requires a specific treatment].
Xanthomatosis, Cerebrotendinous
[Determination and hierarchy of clinical signs for early detection of cerebrotendinous xanthomatosis].
Xeroderma Pigmentosum
DNA polymorphism and risk of esophageal squamous cell carcinoma in a population of North Xinjiang, China.
Xeroderma Pigmentosum
Impact of Occupational Exposures and Genetic Polymorphisms on Recurrence and Progression of Non-Muscle-Invasive Bladder Cancer.
Xeroderma Pigmentosum
Inter-individual variation of smoking-related DNA adducts in lymphocytes-relationship to mRNA levels for CYP1A1 and DNA repair enzymes.
Xeroderma Pigmentosum
Low synthesis of retinoic acid due to impaired cytochrome P450 1a1 expression in mouse xeroderma pigmentosum fibroblasts.
Xeroderma Pigmentosum
Preferential DNA damage in the p53 gene by benzo[a]pyrene metabolites in cytochrome P4501A1-expressing xeroderma pigmentosum group A cells.
Yellow Fever
Bacteria-mediated modification of insecticide toxicity in the yellow fever mosquito, Aedes aegypti.
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Release 2023.1 (January 2023)
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