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Enzyme Nomenclature
Information on EC 1.14.13.B21 - (1'S)-averantin monooxygenase
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The expected taxonomic range for this enzyme is: Aspergillus parasiticus
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EC NUMBER 
COMMENTARY 
1.14.13.B21
preliminary BRENDA-supplied EC number
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RECOMMENDED NAME
GeneOntology No.
(1'S)-averantin monooxygenase
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(1'S)-averantin + NADPH + H+ + O2 = (1'S,5'R)-hydroxyaverantin + NADP+ + H2O
(1)
-
-
-
(1'S)-averantin + NADPH + H+ + O2 = (1'S,5'S)-hydroxyaverantin + NADP+ + H2O
(2)
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
(1'S)-averantin,NADPH:oxygen oxidoreductase (5'-hydroxylating)
-
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
malfunction
disruption of the avnA gene in the wild-type aflatoxigenic Aspergillus parasiticus strain (SU1-N3) results in a nonaflatoxigenic mutant which accumulates averantin. Precursor feeding studies with this mutant show that norsolorinic acid and averantin are not converted to aflatoxin whereas 5'-hydroxyaverantin, averufanin, averufin, versicolorin A, sterigmatocystin, and O-methylsterigmatocystin are converted to aflatoxins
malfunction
-
disruption of the avnA gene in the wild-type aflatoxigenic Aspergillus parasiticus strain (SU1-N3) results in a nonaflatoxigenic mutant which accumulates averantin. Precursor feeding studies with this mutant show that norsolorinic acid and averantin are not converted to aflatoxin whereas 5'-hydroxyaverantin, averufanin, averufin, versicolorin A, sterigmatocystin, and O-methylsterigmatocystin are converted to aflatoxins
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'R)-hydroxyaverantin + NADP+ + H2O
the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'R)-hydroxyaverantin + NADP+ + H2O
-
the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. No activity with (1'R)-averantin. The enzyme specifically hydroxylates (1'S)-averantin to both diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'R)-hydroxyaverantin + NADP+ + H2O
-
no activity with (1'R)-averantin. The enzyme specifically hydroxylates (1'S)-averantin to both diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'R)-hydroxyaverantin + NADP+ + H2O
the enzyme specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'R)-hydroxyaverantin + NADP+ + H2O
the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'R)-hydroxyaverantin + NADP+ + H2O
the enzyme specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'S)-hydroxyaverantin + NADP+ + H2O
the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'S)-hydroxyaverantin + NADP+ + H2O
-
the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. No activity with (1'R)-averantin. The enzyme specifically hydroxylates (1'S)-averantin to both diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'S)-hydroxyaverantin + NADP+ + H2O
-
no activity with (1'R)-averantin. The enzyme specifically hydroxylates (1'S)-averantin to both diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'S)-hydroxyaverantin + NADP+ + H2O
the enzyme specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'S)-hydroxyaverantin + NADP+ + H2O
the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'S)-hydroxyaverantin + NADP+ + H2O
the enzyme specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'R)-hydroxyaverantin + NADP+ + H2O
Q12732
the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'R)-hydroxyaverantin + NADP+ + H2O
-
the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. No activity with (1'R)-averantin. The enzyme specifically hydroxylates (1'S)-averantin to both diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'R)-hydroxyaverantin + NADP+ + H2O
Q12732
the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'S)-hydroxyaverantin + NADP+ + H2O
Q12732
the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'S)-hydroxyaverantin + NADP+ + H2O
-
the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. No activity with (1'R)-averantin. The enzyme specifically hydroxylates (1'S)-averantin to both diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
(1'S)-averantin + NADPH + H+ + O2
(1'S,5'S)-hydroxyaverantin + NADP+ + H2O
Q12732
the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.13.B21)
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