Information on EC 1.14.13.99 - 24-hydroxycholesterol 7alpha-hydroxylase

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The expected taxonomic range for this enzyme is: Eutheria

EC NUMBER
COMMENTARY
1.14.13.99
-
RECOMMENDED NAME
GeneOntology No.
24-hydroxycholesterol 7alpha-hydroxylase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2 = (24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
show the reaction diagram
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Primary bile acid biosynthesis
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-
SYSTEMATIC NAME
IUBMB Comments
(24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
A heme-thiolate protein (P-450) that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24R)-cholest-5-ene-3beta,24-diol as substrate.
CAS REGISTRY NUMBER
COMMENTARY
149316-80-3
-
288309-90-0
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2
(24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
show the reaction diagram
-
activity is largely restricted to 24-hydroxycholesterol
-
-
?
(24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2
(24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
show the reaction diagram
-
activity is largely restricted to 24-hydroxycholesterol
-
-
?
(24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2
(24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
show the reaction diagram
Q9JKJ9
activity is largely restricted to 24-hydroxycholesterol
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NADPH
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
ciliary nonpigmented of eye
Manually annotated by BRENDA team
-
ciliary nonpigmented epithelium
Manually annotated by BRENDA team
Q9JKJ9
sexually dimorphic expression pattern, higher expression in female than in male
Manually annotated by BRENDA team
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
-
x * 44000, SDS-PAGE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
-
Q9JKJ9