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Enzyme Nomenclature
Information on EC 1.14.13.94 - lithocholate 6beta-hydroxylase
Word Map on EC 1.14.13.94
- 1.14.13.94
- testosterone
- cyp1a2
- ketoconazole
-
6beta-hydroxylation
-
o-deethylase
-
o-dealkylase
- chlorzoxazone
- dextromethorphan
-
cyp3a-dependent
- troleandomycin
- bufuralol
-
2alpha-hydroxylase
-
cyp3a4-mediated
-
7alpha
- s-mephenytoin
- triacetyloleandomycin
-
4'-hydroxylase
-
7-pentoxyresorufin
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
1.14.13.94
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RECOMMENDED NAME
GeneOntology No.
lithocholate 6beta-hydroxylase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
lithocholate + NADPH + H+ + O2 = 6beta-hydroxylithocholate + NADP+ + H2O
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SYSTEMATIC NAME
IUBMB Comments
lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating)
A heme-thiolate protein (P-450). Expression of the gene for this enzyme is 50-fold higher in male compared to female hamsters [1].
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CAS REGISTRY NUMBER
COMMENTARY
9075-83-6
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
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hydroxylations of bile acids by reconstituted systems from rat liver microsomes
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-
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lithocholate + NADPH + H+ + O2
6beta-hydroxylithocholate + NADP+ + H2O
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-
-
-
?
lithocholate + NADPH + H+ + O2
6beta-hydroxylithocholate + NADP+ + H2O
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a STAT factor mediates the sexually dimorphic regulation of hepatic cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase gene expression by growth hormone
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-
?
lithocholate + NADPH + H+ + O2
6beta-hydroxylithocholate + NADP+ + H2O
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in male hamsters, 6beta-hydroxylation is the major pathway for detoxification of lithocholate. Likely CYP3A10 is responsible for this activity
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-
?
lithocholate + NADPH + H+ + O2
6beta-hydroxylithocholate + NADP+ + H2O
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the male-specific P450 catalyzes the reaction. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene. STAT 5a and STAT 5b mediates GH-dependent regulation of CYP3A10/6beta-hydroxylase promoter activity
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-
?
lithocholate + NADPH + H+ + O2
6beta-hydroxylithocholate + NADP+ + H2O
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-
-
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?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
lithocholate + NADPH + H+ + O2
6beta-hydroxylithocholate + NADP+ + H2O
-
a STAT factor mediates the sexually dimorphic regulation of hepatic cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase gene expression by growth hormone
-
-
?
lithocholate + NADPH + H+ + O2
6beta-hydroxylithocholate + NADP+ + H2O
-
in male hamsters, 6beta-hydroxylation is the major pathway for detoxification of lithocholate. Likely CYP3A10 is responsible for this activity
-
-
?
lithocholate + NADPH + H+ + O2
6beta-hydroxylithocholate + NADP+ + H2O
-
the male-specific P450 catalyzes the reaction. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene. STAT 5a and STAT 5b mediates GH-dependent regulation of CYP3A10/6beta-hydroxylase promoter activity
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-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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expression of CYP 3A10 protein is male-specific in hamster liver microsome
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male-specific enzyme. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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expression of CYP 3A10 protein is male-specific in hamster liver microsome
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.13.94)
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