Information on EC 1.14.13.56 - dihydrosanguinarine 10-monooxygenase

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The expected taxonomic range for this enzyme is: Eschscholzia californica

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EC NUMBER
COMMENTARY hide
1.14.13.56
-
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RECOMMENDED NAME
GeneOntology No.
dihydrosanguinarine 10-monooxygenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dihydrosanguinarine + NADPH + H+ + O2 = 10-hydroxydihydrosanguinarine + NADP+ + H2O
show the reaction diagram
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
reduction
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
-
-
Isoquinoline alkaloid biosynthesis
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-
Metabolic pathways
-
-
sanguinarine and macarpine biosynthesis
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-
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SYSTEMATIC NAME
IUBMB Comments
dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)
A heme-thiolate protein (P-450) involved in benzophenanthridine alkaloid synthesis in higher plants.
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CAS REGISTRY NUMBER
COMMENTARY hide
144388-41-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dihydrosanguinarine + NADPH + O2
10-hydroxydihydrosanguinarine + NADP+
show the reaction diagram
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-
-
-
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome P450
-
dependent on
-
NADPH
-
required, no activity with NADH
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
CO
-
strong inhibition in the dark, effect is partly reversible by illumination
cytochrome c
-
-
ketoconazole
-
-
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
top print hide
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
associated with
-
Manually annotated by BRENDA team
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.13.56)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)