Information on EC 1.14.13.229 - tert-butyl alcohol monooxygenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.14.13.229
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RECOMMENDED NAME
GeneOntology No.
tert-butyl alcohol monooxygenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
tert-butyl alcohol + NADPH + H+ + O2 = 2-methylpropane-1,2-diol + NADP+ + H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
methyl tert-butyl ether degradation
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SYSTEMATIC NAME
IUBMB Comments
tert-butyl alcohol,NADPH:oxygen oxidoreductase
The enzyme, characterized from the bacterium Aquincola tertiaricarbonis, is a Rieske nonheme mononuclear iron oxygenase. It can also act, with lower efficiency, on propan-2-ol, converting it to propane-1,2-diol. Depending on the substrate, the enzyme also catalyses EC 1.14.19.48, tert-amyl alcohol desaturase.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
tert-butyl alcohol + NADPH + H+ + O2
2-methylpropan-1,2-diol + NADP+ + 2 H2O
show the reaction diagram
tert-butyl alcohol + NADPH + H+ + O2
2-methylpropane-1,2-diol + NADP+ + H2O
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
[2Fe-2S]-center
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sequence contains conserved amino acid motif -R-x12-CxHRxxxLxxG-x8-CxYHR-x6-G- for the Rieske [2Fe-2S] binding domain
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Iron
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sequence contains conserved amino acid motif (-D/E)xxxDxxHxxxxH- for a mononuclear iron binding domain
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
55000
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x * 55000, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression is induced after growth on n-propane, n-hexane, n-hexadecane and on tert-butyl alcohol