Information on EC 1.14.13.228 - jasmonic acid 12-hydroxylase

for references in articles please use BRENDA:EC1.14.13.228
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The expected taxonomic range for this enzyme is: Magnaporthe oryzae

EC NUMBER
COMMENTARY hide
1.14.13.228
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RECOMMENDED NAME
GeneOntology No.
jasmonic acid 12-hydroxylase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(-)-jasmonate + NADPH + H+ + O2 = trans-12-hydroxyjasmonate + NADP+ + H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
tuberonate glucoside biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
jasmonate,NADPH:oxygen oxidoreductase (12-hydroxylating)
Although believed to occur in plants, the enzyme has so far been characterized only from the rice blast fungus, Magnaporthe oryzae. The fungus strategically deploys the enzyme to hydroxylate and inactivate endogenous jasmonate to evade the jasmonate-based innate immunity in rice plants.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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the reaction product 12-hydroxyjasmonate is secreted during host penetration and helps evade the defense response. Loss of Abm in Magnaporthe oryzae leads to accumulation of methyljasmonate, which induces host defense and blocks invasive growth. Exogenously added 12-hydroxyjasmonate markedly attenuates immunity induced by loss of ABM in rice
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(-)-jasmonate + NADPH + H+ + O2
trans-12-hydroxyjasmonate + NADP+ + H2O
show the reaction diagram
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE