Information on EC 1.14.13.227 - propane 2-monooxygenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.14.13.227
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RECOMMENDED NAME
GeneOntology No.
propane 2-monooxygenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
propane + NADH + H+ + O2 = propan-2-ol + NAD+ + H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Propanoate metabolism
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propane degradation II
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propane degradation I
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SYSTEMATIC NAME
IUBMB Comments
propane,NADH:oxygen oxidoreductase (2-hydroxylating)
The enzyme, characterized from several bacterial strains, is a multicomponent dinuclear iron monooxygenase that includes a hydroxylase, an NADH-dependent reductase, and a coupling protein. The enzyme has several additional activities, including acetone monooxygenase (acetol-forming) and phenol 4-monooxygenase.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Q768T5 i.e. subunit PrmA, Q768T4 i.e. subunit PrmB, Q768T3 i.e. subunit PrmC, Q768T2 i.e. subunit PrmD
Q768T5 and Q768T4 andQ768T3 and Q768T2
UniProt
Manually annotated by BRENDA team
large subunit PrmA
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
propane + NADPH + H+ + O2
propan-2-ol + NADP+ + H2O
show the reaction diagram
Q08KD8 and Q08KD7 andQ08KD6 and Q08KD5, Q08KE2 and Q08KE1 andQ08KD0 and Q08KE9
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Iron
Q768T5 and Q768T4 andQ768T3 and Q768T2
enzyme is a dinuclear-iron-containing multicomponent monooxygenase
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression of prm gene clusters is induced by gaseous n-alkanes (C2-C4) except methane; expression of prm gene clusters is induced by gaseous n-alkanes (C2-C4) except methane
Q08KD8 and Q08KD7 andQ08KD6 and Q08KD5, Q08KE2 and Q08KE1 andQ08KD0 and Q08KE9
growth on propane elicits the upregulation of gene clusters associated with the oxidation of propane and the oxidation of substituted benzenes
polycistronic transcription of the prm genes is induced during its growth on propane
Q768T5 and Q768T4 andQ768T3 and Q768T2
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
degradation
Rhodococcus sp. strain RHA1 can constitutively degrade N-nitrosodimethylamine. Activity toward this water contaminant is enhanced by approximately 500fold after growth on propane. Growth on propane elicits the upregulation of gene clusters associated with the oxidation of propane and the oxidation of substituted benzenes