Information on EC 1.14.13.19 - taxifolin 8-monooxygenase

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The expected taxonomic range for this enzyme is: Pseudomonas sp.

EC NUMBER
COMMENTARY
1.14.13.19
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RECOMMENDED NAME
GeneOntology No.
taxifolin 8-monooxygenase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O
show the reaction diagram
A flavoprotein, converting a flavanol into a flavanone. Also acts on fustin, but not on catechin, quercitin or mollisacidin
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-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
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reduction
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-
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SYSTEMATIC NAME
IUBMB Comments
taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)
A flavoprotein, converting a flavanol into a flavanone. Also acts on fustin, but not on catechin, quercetin or mollisacidin.
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
taxifolin hydroxylase
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-
-
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CAS REGISTRY NUMBER
COMMENTARY
39307-19-2
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(-)-fustin + NADH + O2
? + NAD+ + H2O
show the reaction diagram
-
-
product not identified
?
taxifolin + NADH + O2
2,3-dihydrogossypetin + NAD+ + H2O
show the reaction diagram
-
-
-
?
taxifolin + NADPH + O2
2,3-dihydrogossypetin + NADP+ + H2O
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
taxifolin + NADH + O2
2,3-dihydrogossypetin + NAD+ + H2O
show the reaction diagram
-
-
-
?
taxifolin + NADPH + O2
2,3-dihydrogossypetin + NADP+ + H2O
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NADH
-
twice oxidized compared to NADPH
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6
-
20% of maximal activity
395990
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
40
-
25% loss of activity in 10 min
395990
50
-
95% loss of activity in 10 min
395990
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE