Information on EC 1.14.13.19 - taxifolin 8-monooxygenase

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The expected taxonomic range for this enzyme is: Pseudomonas sp.

EC NUMBER
COMMENTARY
1.14.13.19
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RECOMMENDED NAME
GeneOntology No.
taxifolin 8-monooxygenase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O
show the reaction diagram
A flavoprotein, converting a flavanol into a flavanone. Also acts on fustin, but not on catechin, quercitin or mollisacidin
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-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
-
-
-
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redox reaction
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-
-
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reduction
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SYSTEMATIC NAME
IUBMB Comments
taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)
A flavoprotein, converting a flavanol into a flavanone. Also acts on fustin, but not on catechin, quercetin or mollisacidin.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
taxifolin hydroxylase
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-
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CAS REGISTRY NUMBER
COMMENTARY
39307-19-2
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(-)-fustin + NADH + O2
? + NAD+ + H2O
show the reaction diagram
-
-
product not identified
?
taxifolin + NADH + O2
2,3-dihydrogossypetin + NAD+ + H2O
show the reaction diagram
-
-
-
?
taxifolin + NADPH + O2
2,3-dihydrogossypetin + NADP+ + H2O
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
taxifolin + NADH + O2
2,3-dihydrogossypetin + NAD+ + H2O
show the reaction diagram
-
-
-
?
taxifolin + NADPH + O2
2,3-dihydrogossypetin + NADP+ + H2O
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
NADH
-
twice oxidized compared to NADPH
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6
-
-
20% of maximal activity
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
40
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-
25% loss of activity in 10 min
50
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-
95% loss of activity in 10 min
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE