Information on EC 1.14.13.171 - neopentalenolactone D synthase

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The expected taxonomic range for this enzyme is: Streptomyces

EC NUMBER
COMMENTARY
1.14.13.171
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RECOMMENDED NAME
GeneOntology No.
neopentalenolactone D synthase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
1-deoxy-11-oxopentalenate + NADPH + H+ + O2 = neopentalenolactone D + NADP+ + H2O
show the reaction diagram
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PATHWAY
KEGG Link
MetaCyc Link
neopentalenoketolactone and pentalenate biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (neopentalenolactone-D forming)
A FAD-dependent oxygenase. Isolated from the bacterium Streptomyces avermitilis. The ketone undergoes a biological Baeyer-Villiger reaction.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
penE
Streptomyces exfoliatus UC5319
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pntE
Streptomyces arenae TU46, Streptomyces arenae TUE469
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ptlE
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Streptomyces arenae TUE469
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Manually annotated by BRENDA team
Streptomyces exfoliatus UC5319
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-deoxy-11-oxopentalenate + NADPH + H+ + O2
neopentalenolactone D + NADP+ + H2O
show the reaction diagram
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-
-
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?
1-deoxy-11-oxopentalenate + NADPH + H+ + O2
neopentalenolactone D + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
1-deoxy-11-oxopentalenate + NADPH + H+ + O2
neopentalenolactone D + NADP+ + H2O
show the reaction diagram
Streptomyces arenae, Streptomyces arenae TU46, Streptomyces exfoliatus UC5319, Streptomyces arenae TUE469
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-
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?
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
SUBUNITS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
?
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x * 64000, SDS-PAGE; x * 65826, predicted from amino acid sequence
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
ammonium sulfate precipitation, butyl-Sepharose column chromatography, gel filtration
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Cloned/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
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