Information on EC 1.14.13.134 - beta-amyrin 11-oxidase

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The expected taxonomic range for this enzyme is: Glycyrrhiza uralensis

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EC NUMBER
COMMENTARY hide
1.14.13.134
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RECOMMENDED NAME
GeneOntology No.
beta-amyrin 11-oxidase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11-oxo-beta-amyrin + 2 H2O + NADP+
show the reaction diagram
(1b)
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beta-amyrin + 2 O2 + 2 NADPH + 2 H+ = 11-oxo-beta-amyrin + 3 H2O + 2 NADP+
show the reaction diagram
overall reaction
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beta-amyrin + O2 + NADPH + H+ = 11alpha-hydroxy-beta-amyrin + H2O + NADP+
show the reaction diagram
(1a)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
glycyrrhetinate biosynthesis
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NIL
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-
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SYSTEMATIC NAME
IUBMB Comments
beta-amyrin,NADPH:oxygen oxidoreductase (hydroxylating)
Requires cytochrome P-450. Part of the glycyrrhizin biosynthesis pathway. The enzyme is also able to oxidize 30-hydroxy-beta-amyrin to 11alpha,30-dihydroxy-beta-amyrin but this is not thought to be part of glycyrrhizin biosynthesis.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
11-oxo-beta-amyrin + O2 + NADPH + H+
30-hydroxy-11-oxo-beta-amyrin + H2O + NADP+
show the reaction diagram
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single oxidation reaction catalyzed by CYP72A154
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-
?
30-hydroxy-11-oxo-beta-amyrin + O2 + NADPH + H+
glycyrrhetaldehyde + H2O + NADP+
show the reaction diagram
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single oxidation reaction catalyzed by CYP72A154
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-
?
30-hydroxy-beta-amyrin + O2 + NADPH + H+
11-deoxoglycyrrhetinic acid + H2O + NADP+
show the reaction diagram
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-
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-
?
beta-amyrin + O2 + NADPH + H+
11-oxo-beta-amyrin + H2O + NADP+
show the reaction diagram
beta-amyrin + O2 + NADPH + H+
30-hydroxy-beta-amyrin + H2O + NADP+
show the reaction diagram
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single oxidation reaction catalyzed by CYP72A154
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-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
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not detected in leaves and stems
Manually annotated by BRENDA team
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli DH10Bac cells and in Saccharomyces cerevisiae strain BJ2168
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expressed in Spodoptera frugiperda 9 (Sf9) insect cells
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.13.134)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)