Information on EC 1.14.13.132 - squalene monooxygenase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
1.14.13.132
-
RECOMMENDED NAME
GeneOntology No.
squalene monooxygenase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
epoxidation
-
-
-
-
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
-
diploterol and cycloartenol biosynthesis
-
epoxysqualene biosynthesis
-
Metabolic pathways
-
Sesquiterpenoid and triterpenoid biosynthesis
-
Steroid biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing)
A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7 lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor, NADPH, is coupled via EC 1.6.2.4, NADPH---hemoprotein reductase [5,7].
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
CYP17
-
-
cytochrome P450 17alpha hydroxylase/17,20 lyase
-
-
Erg1 protein
-
-
hydroxylase, squalene
-
-
-
-
oxygenase, squalene mono-
-
-
-
-
SQLE
-
-
squalen expoxidase
-
-
squalene 2,3-oxidocyclase
-
-
-
-
squalene epoxidase
-
-
-
-
squalene epoxidase
-
encoded by gene sqe1 in Arabidopsis thaliana
squalene epoxidase
-
-
squalene epoxidase
-
-
squalene epoxidase
-
-
squalene epoxidase
Q603D5
-
squalene epoxidase
-
-
squalene epoxidase
-
-
squalene epoxidase
-
coding gene PgSQE1, 537 amino acids; coding gene PgSQE2, 545 amino acids
squalene epoxidase
-
-
squalene epoxidase
Q1PID4
-
squalene epoxidase
-
-
squalene epoxidase
-
-
squalene epoxidase
-
-
squalene epoxidase
-
-
squalene epoxidase 1
O65403, O81000, Q9SM02, Q9T064
-
squalene hydroxylase
-
-
-
-
squalene oxydocyclase
-
-
-
-
squalene-2,3-epoxidase
-
-
-
-
squalene-2,3-epoxide cyclase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9029-62-3
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
gene sq1-1, isozyme SQ1; isozymes SQE1-SQE6
UniProt
Manually annotated by BRENDA team
gene sq1-2, isozyme SQ2; isozymes SQE1-SQE6
UniProt
Manually annotated by BRENDA team
gene sq1-3, isozyme SQ3; isozymes SQE1-SQE6
Q9T064
UniProt
Manually annotated by BRENDA team
gene sq1-4, isozyme SQ4; isozymes SQE1-SQE6
UniProt
Manually annotated by BRENDA team
gene ERG1
-
-
Manually annotated by BRENDA team
HepG2 cells
-
-
Manually annotated by BRENDA team
a basidiomycete, gene erg1
-
-
Manually annotated by BRENDA team
enzyme is depressed in anaerobically grown cells
-
-
Manually annotated by BRENDA team
dermatophyte, 6 sequential isolates from 1 patient, resistant to terbinafine
-
-
Manually annotated by BRENDA team
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Fe2+
-
a cytochrome P450 enzyme
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
8.81
-
-, Q1PID4
sequence calculation