Information on EC 1.14.13.115 - angelicin synthase

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The expected taxonomic range for this enzyme is: Pastinaca sativa

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EC NUMBER
COMMENTARY hide
1.14.13.115
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RECOMMENDED NAME
GeneOntology No.
angelicin synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(+)-columbianetin + NADPH + H+ + O2 = angelicin + NADP+ + acetone + 2 H2O
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
(+)-columbianetin,NADPH:oxygen oxidoreductase
This P-450 monooxygenase enzyme is involved in the formation of angular furanocoumarins. Attacks its substrate by syn-elimination of hydrogen from C-3'.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
fragment
SwissProt
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+)-columbianetin + NADPH + H+ + O2
angelicin + NADP+ + acetone + 2 H2O
show the reaction diagram
syn-[3'D]columbianetin + NADPH + O2 + H+
syn-[3'D](anti-3'-hydroxy)-columbianetin + NADP+ + H2O
show the reaction diagram
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-
-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(+)-columbianetin + NADPH + H+ + O2
angelicin + NADP+ + acetone + 2 H2O
show the reaction diagram
C0SJS3
the enzyme is involved in angular furanocoumarin pathway
negligible amounts of a hydroxylated columbianetin by-product
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?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome P450
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-
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0014 - 0.0021
(+)-columbianetin
0.0014 - 0.0038
syn-[3'D]columbianetin
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.32 - 1.9
(+)-columbianetin
0.06 - 3.9
syn-[3'D]columbianetin
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
227 - 920
(+)-columbianetin
11732
30 - 967
syn-[3'D]columbianetin
10729
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in yeast
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.13.115)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)