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DNA-1-ethyladenine + 2-oxoglutarate + O2
DNA-adenine + acetaldehyde + succinate + CO2
-
-
-
ir
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
DNA-1-methylguanine + 2-oxoglutarate + O2
DNA-guanine + formaldehyde + succinate + CO2
weak substrate
-
-
ir
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
weak substrate
-
-
ir
methylated double-stranded bacteriophage lambda + 2-oxoglutarate + O2
double-stranded bacteriophage lambda + formaldehyde + succinate + CO2
-
-
-
?
methylated poly(deoxyadenine) + 2-oxoglutarate + O2
poly(deoxyadenine) + formaldehyde + succinate + CO2
-
-
-
ir
methylated poly(deoxycytosine) + 2-oxoglutarate + O2
poly(deoxycytosine) + formaldehyde + succinate + CO2
-
-
-
ir
methylated RNA bacteriophage MS2 + 2-oxoglutarate + O2
RNA bacteriophage MS2 + formaldehyde + succinate + CO2
isoform ABH3 reactivates methylated single-stranded RNA bacteriophage MS2
-
-
?
1-ethyladenine + O2 + 2-oxoglutarate
adenine + CO2 + acetaldehyde + succinate + H+
-
-
-
-
?
1-methyl-adenine in 5'-dAAAA-1MeA-YYAAA + 2-oxoglutarate + O2
5'-dAAAAAYYAAA + formaldehyde + succinate + CO2
-
-
-
-
?
1-methyl-dAMP + 2-oxoglutarate + O2
dAMP + formaldehyde + succinate + CO2
-
low activity
-
-
?
1-methyl-dATP + 2-oxoglutarate + O2
dATP + formaldehyde + succinate + CO2
-
low activity
-
-
?
1-methyladenine + O2 + 2-oxoglutarate
adenine + CO2 + formaldehyde + succinate + H+
-
-
-
-
?
2'-deoxy-1-methyl-adenosine 3'-phosphate + 2-oxoglutarate + O2
2'-deoxyadenosine 3'-phosphate + formaldehyde + succinate + CO2
-
low activity
-
-
?
3-methylcytosine + O2 + 2-oxoglutarate
cytosine + CO2 + formaldehyde + succinate + H+
-
-
-
-
?
d(Tpm1A) + 2-oxoglutarate + O2
d(TpA) + formaldehyde + succinate + CO2
-
low activity
-
-
?
d(Tpm1ApT) + 2-oxoglutarate + O2
d(TpApT) + formaldehyde + succinate + CO2
-
low activity
-
-
?
DNA-1,6-ethenoadenine + O2
DNA-adenine + glyoxal
-
-
-
-
?
DNA-1-ethyladenine + 2-oxoglutarate + O2
DNA-adenine + acetaldehyde + succinate + CO2
-
-
-
ir
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
DNA-1-methyldeoxyadenine + 2-oxoglutarate + O2
DNA-deoxyadenine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methylguanine + 2-oxoglutarate + O2
DNA-guanine + formaldehyde + succinate + CO2
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
DNA-base-CH3 + 2-oxoglutarate + O2
DNA-base + formaldehyde + succinate + CO2
-
-
-
-
?
methylated luciferase-mRNA + 2-oxoglutarate + O2
luciferase-mRNA + formaldehyde + succinate + CO2
-
-
-
-
?
methylated poly(deoxyadenine) + 2-oxoglutarate + O2
poly(deoxyadenine) + formaldehyde + succinate + CO2
-
-
-
ir
methylated poly(deoxycytosine) + 2-oxoglutarate + O2
poly(deoxycytosine) + formaldehyde + succinate + CO2
-
-
-
ir
methylated poly(deoxythymine) + 2-oxoglutarate + O2
poly(deoxythymine) + formaldehyde + succinate + CO2
-
-
-
-
?
methylated tRNA-Phe + 2-oxoglutarate + O2
tRNAPhe + formaldehyde + succinate + CO2
-
-
-
-
?
N1-methyl-ATP + 2-oxoglutarate + O2
ATP + formaldehyde + succinate + CO2
-
low activity
-
-
?
N3-methylcytosine + 2-oxoglutarate + O2
cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
poly(dm1A) + 2-oxoglutarate + O2
poly(dA) + formaldehyde + succinate + CO2
-
low activity
-
-
?
RNA-1-methyladenine + 2-oxoglutarate + O2
RNA-adenine + formaldehyde + succinate + CO2
-
-
-
-
?
RNA-3-methylcytosine + 2-oxoglutarate + O2
RNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
tRNA-1-methylguanine + 2-oxoglutarate + O2
tRNA-guanine + formaldehyde + succinate + CO2
-
-
-
-
?
additional information
?
-
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
good substrate
-
-
ir
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
good substrate
-
-
ir
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
good substrate
-
-
ir
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
DNA-1-methyladenine is demethylated by isoforms ABH2 and ABH3
-
-
?
DNA-1-methylguanine + 2-oxoglutarate + O2
DNA-guanine + formaldehyde + succinate + CO2
weak substrate
-
-
ir
DNA-1-methylguanine + 2-oxoglutarate + O2
DNA-guanine + formaldehyde + succinate + CO2
-
DNA-1-methylguanine is also repaired by AlkB, but less efficiently as DNA-1-methyladenine or DNA-3-methylcytosine
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
good substrate
-
-
ir
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
DNA-1-methylcytosine is demethylated by isoforms ABH2 and ABH3. Isoform ABH1 exclusively repairs DNA-3-methylcytosine in single-stranded DNA with low activity
-
-
?
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
weak substrate
-
-
ir
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
-
3-methylthymine residues in DNA is repaired inefficiently in vivo. The ABH3 protein repairs 3-methylthymine in both single-stranded and double-stranded polydeoxynucleotides, whereas the ABH2 protein prefers a duplex substrate
-
-
?
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
-
DNA-3-methylthymine is also repaired by AlkB, but less efficiently as DNA-1-methyladenine or DNA-3-methylcytosine. Isoform FTO repairs DNA-3-methylthymine
-
-
?
additional information
?
-
-
ABH3 also repairs RNA. ABH3 prefers single-stranded nucleic acids
-
-
?
additional information
?
-
ABH3 also repairs RNA. ABH3 prefers single-stranded nucleic acids
-
-
?
additional information
?
-
isoform ABH2 shows some preference for methylated poly(dC) over methylated poly(dA) and also prefers a single-stranded substrate. Isoform ABH3 can also demethylate 1-methyladenine in RNA
-
-
?
additional information
?
-
isoform ABH2 shows some preference for methylated poly(dC) over methylated poly(dA) and also prefers a single-stranded substrate. Isoform ABH3 can also demethylate 1-methyladenine in RNA
-
-
?
additional information
?
-
-
repair of alkylated poly(A) by ABH3 is almost as efficient as repair of poly(dA), and repair of poly(C) is substantially more efficient than repair of poly(dA), although not as good as repair of poly(dC) and single-stranded bacteriophage M13 DNA
-
-
?
additional information
?
-
repair of alkylated poly(A) by ABH3 is almost as efficient as repair of poly(dA), and repair of poly(C) is substantially more efficient than repair of poly(dA), although not as good as repair of poly(dC) and single-stranded bacteriophage M13 DNA
-
-
?
additional information
?
-
-
isoform ABH2 does not reactivate methylated RNA bacteriophage MS2 or methylated double-stranded bacteriophage lambda
-
-
?
additional information
?
-
isoform ABH2 does not reactivate methylated RNA bacteriophage MS2 or methylated double-stranded bacteriophage lambda
-
-
?
additional information
?
-
-
ABH3 prefers single-stranded DNA and RNA substrates, whereas ABH2 can repair damage in both single- and double-stranded DNA. Isoform ABH1 does not show any DNA repair activity
-
-
?
additional information
?
-
-
ABH2 does not repair RNA. ABH2 acts more efficiently on double-stranded DNA
-
-
?
additional information
?
-
ABH2 does not repair RNA. ABH2 acts more efficiently on double-stranded DNA
-
-
?
additional information
?
-
-
isoform ABH2 prefers double-stranded DNA while isoforms ABH3 and ABH1 work better on single-stranded substrates
-
-
?
additional information
?
-
isoform ABH2 shows some preference for methylated poly(dA) over methylated poly(dC) and also prefers a double-stranded substrate. not ABH2 cannot demethylate 1-methyladenine in RNA
-
-
?
additional information
?
-
isoform ABH2 shows some preference for methylated poly(dA) over methylated poly(dC) and also prefers a double-stranded substrate. not ABH2 cannot demethylate 1-methyladenine in RNA
-
-
?
additional information
?
-
-
isoform ABH3 prefers single-stranded DNA (also under magnesium-free conditions) and RNA, while isoform ABH2 prefers double-stranded DNA (only in the presence of magnesium) and RNA
-
-
?
additional information
?
-
-
the enzyme does not demethylate 3-methyladenine, 7-methyladenine, 7-methylguanine, thymine (5-methyluracil), and 5-methylcytosine
-
-
?
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Breast Neoplasms
CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer.
Carcinogenesis
Analysis of differentially expressed genes in human rectal carcinoma using suppression subtractive hybridization.
Carcinogenesis
DNA repair is indispensable for survival after acute inflammation.
Carcinogenesis
Fluorescence Probes for ALKBH2 Allow the Measurement of DNA Alkylation Repair and Drug Resistance Responses.
Carcinogenesis
The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.
Carcinoma
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
Carcinoma
ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression.
Carcinoma
ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals.
Carcinoma in Situ
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
Carcinoma in Situ
ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression.
Carcinoma, Non-Small-Cell Lung
Down-regulation of ALKBH2 increases cisplatin sensitivity in H1299 lung cancer cells.
Colitis
DNA repair is indispensable for survival after acute inflammation.
Colonic Neoplasms
DNA repair is indispensable for survival after acute inflammation.
Colorectal Neoplasms
ALKBH2 inhibition alleviates malignancy in colorectal cancer by regulating BMI1-mediated activation of NF-?B pathway.
dna oxidative demethylase deficiency
Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming?.
Glioblastoma
The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells.
Hodgkin Disease
Epigenetic Loss of m1A RNA Demethylase ALKBH3 in Hodgkin Lymphoma Targets Collagen Conferring Poor Clinical Outcome.
Intellectual Disability
Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification.
Leukemia
ALKBH2 inhibition alleviates malignancy in colorectal cancer by regulating BMI1-mediated activation of NF-?B pathway.
Lung Neoplasms
ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.
Lung Neoplasms
Down-regulation of ALKBH2 increases cisplatin sensitivity in H1299 lung cancer cells.
Lung Neoplasms
TP53 gene status is a critical determinant of phenotypes induced by ALKBH3 knockdown in non-small cell lung cancers.
Neoplasm Metastasis
Indenone derivatives as inhibitor of human DNA dealkylation repair enzyme AlkBH3.
Neoplasms
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
Neoplasms
AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells.
Neoplasms
ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy.
Neoplasms
ALKBH2 inhibition alleviates malignancy in colorectal cancer by regulating BMI1-mediated activation of NF-?B pathway.
Neoplasms
ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression.
Neoplasms
ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals.
Neoplasms
ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin.
Neoplasms
Anti-Tumor Effect of AlkB Homolog 3 Knockdown in Hormone- Independent Prostate Cancer Cells.
Neoplasms
Association of AlkB homolog 3 expression with tumor recurrence and unfavorable prognosis in hepatocellular carcinoma.
Neoplasms
CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer.
Neoplasms
DNA repair is indispensable for survival after acute inflammation.
Neoplasms
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.
Neoplasms
Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker.
Neoplasms
Fluorescence Probes for ALKBH2 Allow the Measurement of DNA Alkylation Repair and Drug Resistance Responses.
Neoplasms
Human ALKBH3-induced m1A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells.
Neoplasms
Indenone derivatives as inhibitor of human DNA dealkylation repair enzyme AlkBH3.
Neoplasms
The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants.
Neoplasms
The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.
Neoplasms
TP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy.
Neoplasms
Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs.
Neoplasms
Unraveling a connection between DNA demethylation repair and cancer.
Prostatic Hyperplasia
Anti-Tumor Effect of AlkB Homolog 3 Knockdown in Hormone- Independent Prostate Cancer Cells.
Prostatic Neoplasms
ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.
Prostatic Neoplasms
Anti-Tumor Effect of AlkB Homolog 3 Knockdown in Hormone- Independent Prostate Cancer Cells.
Prostatic Neoplasms
Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker.
Prostatic Neoplasms
The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.
Squamous Cell Carcinoma of Head and Neck
ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy.
Urinary Bladder Neoplasms
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
Urinary Bladder Neoplasms
ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression.
Urinary Bladder Neoplasms
ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals.
Urinary Bladder Neoplasms
ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin.
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Yi, C.; Yang, C.G.; He, C.
A non-heme iron-mediated chemical demethylation in DNA and RNA
Acc. Chem. Res.
42
519-529
2009
Escherichia coli, Homo sapiens
brenda
Koivisto, P.; Duncan, T.; Lindahl, T.; Sedgwick, B.
Minimal methylated substrate and extended substrate range of Escherichia coli AlkB protein, a 1-methyladenine-DNA dioxygenase
J. Biol. Chem.
278
44348-44354
2003
Escherichia coli, Homo sapiens
brenda
Koivisto, P.; Robins, P.; Lindahl, T.; Sedgwick, B.
Demethylation of 3-methylthymine in DNA by bacterial and human DNA dioxygenases
J. Biol. Chem.
279
40470-40474
2004
Escherichia coli, Homo sapiens
brenda
Sedgwick, B.; Robins, P.; Lindahl, T.
Direct removal of alkylation damage from DNA by AlkB and related DNA dioxygenases
Methods Enzymol.
408
108-120
2006
Escherichia coli (P05050), Homo sapiens (Q6NS38), Homo sapiens (Q96Q83)
brenda
Ougland, R.; Zhang, C.M.; Liiv, A.; Johansen, R.F.; Seeberg, E.; Hou, Y.M.; Remme, J.; Falnes, P.O.
AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation
Mol. Cell
16
107-116
2004
Escherichia coli, Homo sapiens
brenda
Aas, P.A.; Otterlei, M.; Falnes, P.O.; Vagbo, C.B.; Skorpen, F.; Akbari, M.; Sundheim, O.; Bjoras, M.; Slupphaug, G.; Seeberg, E.; Krokan, H.E.
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA
Nature
421
859-863
2003
Escherichia coli, Homo sapiens, Homo sapiens (Q96Q83)
brenda
Mishina, Y.; Lee, C.H.; He, C.
Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies
Nucleic Acids Res.
32
1548-1554
2004
Escherichia coli, Homo sapiens
brenda
Falnes, P.O.; Bjoras, M.; Aas, P.A.; Sundheim, O.; Seeberg, E.
Substrate specificities of bacterial and human AlkB proteins
Nucleic Acids Res.
32
3456-3461
2004
Escherichia coli, Homo sapiens
brenda
Falnes, P.O.
Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins
Nucleic Acids Res.
32
6260-6267
2004
Escherichia coli, Homo sapiens
brenda
Duncan, T.; Trewick, S.C.; Koivisto, P.; Bates, P.A.; Lindahl, T.; Sedgwick, B.
Reversal of DNA alkylation damage by two human dioxygenases
Proc. Natl. Acad. Sci. USA
99
16660-5
2002
Homo sapiens
brenda
Li, P.; Gao, S.; Wang, L.; Yu, F.; Li, J.; Wang, C.; Li, J.; Wong, J.
ABH2 couples regulation of ribosomal DNA transcription with DNA alkylation repair
Cell Rep.
4
817-829
2013
Homo sapiens
brenda
Beharry, A.A.; Lacoste, S.; OConnor, T.R.; Kool, E.T.
Fluorescence monitoring of the oxidative repair of DNA alkylation damage by ALKBH3, a prostate cancer marker
J. Am. Chem. Soc.
138
3647-3650
2016
Homo sapiens
brenda
Wang, P.; Wu, J.; Ma, S.; Zhang, L.; Yao, J.; Hoadley, K.A.; Wilkerson, M.D.; Perou, C.M.; Guan, K.L.; Ye, D.; Xiong, Y.
Oncometabolite D-2-hydroxyglutarate inhibits ALKBH DNA repair enzymes and sensitizes IDH mutant cells to alkylating agents
Cell Rep.
13
2353-2361
2015
Homo sapiens
brenda
Silvestrov, P.; Mueller, T.A.; Clark, K.N.; Hausinger, R.P.; Cisneros, G.A.
Homology modeling, molecular dynamics, and site-directed mutagenesis study of AlkB human homolog 1 (ALKBH1)
J. Mol. Graph. Model.
54
123-130
2014
Homo sapiens
brenda
Soll, J.M.; Sobol, R.W.; Mosammaparast, N.
Regulation of DNA alkylation damage repair lessons and therapeutic opportunities
Trends Biochem. Sci.
42
206-218
2017
Homo sapiens (Q6NS38)
brenda