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Reference on EC 1.14.11.30 - hypoxia-inducible factor-asparagine dioxygenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Koivunen, P.; Hirsilae, M.; Guenzler, V.; Kivirikko, K.I.; Myllyharju, J.
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
J. Biol. Chem.
279
9899-9904
2004
Homo sapiens
Manually annotated by BRENDA team
Hewitson, K.S.; McNeill, L.A.; Riordan, M.V.; Tian, Y.M.; Bullock, A.N.; Welford, R.W.; Elkins, J.M.; Oldham, N.J.; Bhattacharya, S.; Gleadle, J.M.; Ratcliffe, P.J.; Pugh, C.W.; Schofield, C.J.
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
J. Biol. Chem.
277
26351-26355
2002
Homo sapiens
Manually annotated by BRENDA team
Lando, D.; Peet, D.J.; Whelan, D.A.; Gorman, J.J.; Whitelaw, M.L.
Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
Science
295
858-861
2002
Homo sapiens
Manually annotated by BRENDA team
Pappalardi, M.B.; McNulty, D.E.; Martin, J.D.; Fisher, K.E.; Jiang, Y.; Burns, M.C.; Zhao, H.; Ho, T.; Sweitzer, S.; Schwartz, B.; Annan, R.S.; Copeland, R.A.; Tummino, P.J.; Luo, L.
Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites
Biochem. J.
436
363-369
2011
Homo sapiens
Manually annotated by BRENDA team
Kwon, H.S.; Choi, Y.K.; Kim, J.W.; Park, Y.K.; Yang, E.G.; Ahn, D.R.
Inhibition of a prolyl hydroxylase domain (PHD) by substrate analog peptides
Bioorg. Med. Chem. Lett.
21
4325-4328
2011
Homo sapiens
Manually annotated by BRENDA team
Cavadas, M.A.; Nguyen, L.K.; Cheong, A.
Hypoxia-inducible factor (HIF) network: insights from mathematical models
Cell Commun. Signal.
11
42
2013
Homo sapiens
Manually annotated by BRENDA team
Masson, N.; Singleton, R.S.; Sekirnik, R.; Trudgian, D.C.; Ambrose, L.J.; Miranda, M.X.; Tian, Y.M.; Kessler, B.M.; Schofield, C.J.; Ratcliffe, P.J.
The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
EMBO Rep.
13
251-257
2012
Homo sapiens
Manually annotated by BRENDA team
Nguyen, L.K.; Cavadas, M.A.; Scholz, C.C.; Fitzpatrick, S.F.; Bruning, U.; Cummins, E.P.; Tambuwala, M.M.; Manresa, M.C.; Kholodenko, B.N.; Taylor, C.T.; Cheong, A.
A dynamic model of the hypoxia-inducible factor 1alpha (HIF-1alpha) network
J. Cell Sci.
126
1454-1463
2013
Homo sapiens
Manually annotated by BRENDA team
Flagg, S.C.; Martin, C.B.; Taabazuing, C.Y.; Holmes, B.E.; Knapp, M.J.
Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH)
J. Inorg. Biochem.
113
25-30
2012
Homo sapiens
Manually annotated by BRENDA team
Pelletier, J.; Dayan, F.; Durivault, J.; Ilc, K.; Pecou, E.; Pouyssegur, J.; Mazure, N.M.
The asparaginyl hydroxylase factor-inhibiting HIF is essential for tumor growth through suppression of the p53-p21 axis
Oncogene
31
2989-3001
2012
Homo sapiens
Manually annotated by BRENDA team
Bishop, T.; Ratcliffe, P.J.
HIF hydroxylase pathways in cardiovascular physiology and medicine
Circ. Res.
117
65-79
2015
Homo sapiens
Manually annotated by BRENDA team
Chan, M.C.; Ilott, N.E.; Schoedel, J.; Sims, D.; Tumber, A.; Lippl, K.; Mole, D.R.; Pugh, C.W.; Ratcliffe, P.J.; Ponting, C.P.; Schofield, C.J.
Tuning the transcriptional response to hypoxia by inhibiting hypoxia-inducible factor (HIF) prolyl and asparaginyl hydroxylases
J. Biol. Chem.
291
20661-20673
2016
Homo sapiens
Manually annotated by BRENDA team
Hangasky, J.A.; Taabazuing, C.Y.; Martin, C.B.; Eron, S.J.; Knapp, M.J.
The facial triad in the alpha-ketoglutarate dependent oxygenase FIH A role for sterics in linking substrate binding to O2 activation
J. Inorg. Biochem.
166
26-33
2017
Homo sapiens (Q9NWT6)
Manually annotated by BRENDA team
Ma, M.; Hua, S.; Li, G.; Wang, S.; Cheng, X.; He, S.; Wu, P.; Chen, X.
Prolyl hydroxylase domain protein 3 and asparaginyl hydroxylase factor inhibiting HIF-1 levels are predictive of tumoral behavior and prognosis in hepatocellular carcinoma
Oncotarget
8
12983-13002
2017
Homo sapiens
Manually annotated by BRENDA team
Jin, P.; Kang, J.; Lee, M.K.; Park, J.W.
Ferritin heavy chain controls the HIF-driven hypoxic response by activating the asparaginyl hydroxylase FIH
Biochem. Biophys. Res. Commun.
499
475-481
2018
Homo sapiens (Q9NWT6)
Manually annotated by BRENDA team
Sim, J.; Cowburn, A.S.; Palazon, A.; Madhu, B.; Tyrakis, P.A.; Macias, D.; Bargiela, D.M.; Pietsch, S.; Gralla, M.; Evans, C.E.; Kittipassorn, T.; Chey, Y.C.J.; Branco, C.M.; Rundqvist, H.; Peet, D.J.; Johnson, R.S.
The factor inhibiting HIF asparaginyl hydroxylase regulates oxidative metabolism and accelerates metabolic adaptation to hypoxia
Cell Metab.
27
898-913.e7
2018
Mus musculus (Q8BLR9)
Manually annotated by BRENDA team
Chaplin, V.; Hangasky, J.; Huang, H.; Duan, R.; Maroney, M.; Knapp, M.
Chloride supports O2 activation in the D201G facial triad variant of factor-inhibiting hypoxia inducible factor, an alpha-ketoglutarate dependent oxygenase
Inorg. Chem.
57
12588-12595
2018
Homo sapiens (Q9NWT6)
Manually annotated by BRENDA team
Pickel, C.; Taylor, C.; Scholz, C.
Genetic knockdown and pharmacologic inhibition of hypoxia-inducible factor (HIF) hydroxylases
Methods Mol. Biol.
1742
1-14
2018
Homo sapiens
Manually annotated by BRENDA team