Reference on EC 1.14.11.16 - peptide-aspartate beta-dioxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dinchuk, J.E.; Henderson, N.L.; Burn, T.C.; Huber, R.; Ho, S.P.; Link, J.; O'Neil, K.T.; Focht, R.J.; Scully, M.S.; Hollis, J.M.; Hollis, G.F.; Friedman, P.A.
Aspartyl beta-hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin
J. Biol. Chem.
275
39543-39554
2000
Mus musculus
Ince, N.; De la Monte, S.M.; Wands, J.R.
Overexpression of human aspartyl (asparaginyl) beta-hydroxylase is associated with malignant transformation
Cancer Res.
60
1261-1266
2000
Homo sapiens
McGinnis, K.; Ku, G.M.; Fu, J.; Stern, A.M.; Friedman, P.A.
The five cysteine residues located in the active site region of bovine aspartyl (asparaginyl) beta-hydroxylase are not essential for catalysis
Biochim. Biophys. Acta
1387
454-456
1998
Bos taurus
Lavaissiere, L.; Jia, S.; Nishiyama, M.; de la Monte, S.; Stern, A.M.; Wands, J.R.; Friedman, P.A.
Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma
J. Clin. Invest.
98
1313-1323
1996
Homo sapiens
McGinnis, K.; Ku, G.M.; VanDusen, W.J.; Fu, J.; Garsky, V.; Stern, A.M.; Friedman, P.A.
Site-directed mutagenesis of residues in a conserved region of bovine aspartyl (asparaginyl) beta-hydroxylase: Evidence that histidine 675 has a role in binding Fe2+
Biochemistry
35
3957-3962
1996
Bos taurus
Jia, S.; McGinnis, K.; VanDusen, W.J.; Burke, C.J.; Kuo, A.; Griffin, P.R.; Sardana, M.K.; Elliston, K.O.; Stern, A.M.; Friedman, P.A.
A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases
Proc. Natl. Acad. Sci. USA
91
7227-7231
1994
Bos taurus
Korioth, F.; Gieffers, C.; Frey, J.
Cloning and characterization of the human gene encoding aspartyl beta-hydroxylase
Gene
150
395-399
1994
Homo sapiens
Wang, Q.; VanDusen, W.J.; Petrosky, C.J.; Garsky, V.M.; Stern, A.M.; Friedman, P.A.
Bovine liver aspartyl beta-hydroxylase. Purification and characterization
J. Biol. Chem.
266
14004-14010
1991
Bos taurus
Gronke, R.S.; Welsch, D.J.; VanDusen, W.J.; Garsky, V.M.; Sardana, M.K.; Stern, A.M.; Friedman, P.A.
Partial purification and characterization of bovine liver aspartyl beta-hydroxylase
J. Biol. Chem.
265
8558-8565
1990
Bos taurus
Gronke, R.S.; VanDusen, W.J.; Garsky, V.M.; Jacobs, J.W.; Sardana, M.K.; Stern, A.M.; Friedman, P.A.
Aspartyl beta-hydroxylase: in vitro hydroxylation of a synthetic peptide based on the structure of the first growth factor-like domain of human factor IX
Proc. Natl. Acad. Sci. USA
86
3609-3613
1989
Mus musculus, Rattus norvegicus
Lancaster, D.E.; McDonough, M.A.; Schofield, C.J.
Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases
Biochem. Soc. Trans.
32
943-945
2004
Homo sapiens
Linke, S.; Stojkoski, C.; Kewley, R.J.; Booker, G.W.; Whitelaw, M.L.; Peet, D.J.
Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor
J. Biol. Chem.
279
14391-14397
2004
Homo sapiens
Koivunen, P.; Hirsilae, M.; Guenzler, V.; Kivirikko, K.I.; Myllyharju, J.
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
J. Biol. Chem.
279
9899-9904
2004
Homo sapiens (Q9NWT6)
Cantarini, M.C.; de la Monte, S.M.; Pang, M.; Tong, M.; DErrico, A.; Trevisani, F.; Wands, J.R.
Aspartyl-asparagyl beta hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms
Hepatology
44
446-457
2006
Homo sapiens
Gundogan, F.; Elwood, G.; Greco, D.; Rubin, L.P.; Pinar, H.; Carlson, R.I.; Wands, J.R.; de la Monte, S.M.
Role of aspartyl-(asparaginyl) beta-hydroxylase in placental implantation: Relevance to early pregnancy loss
Hum. Pathol.
38
50-59
2007
Homo sapiens
de la Monte, S.M.; Tamaki, S.; Cantarini, M.C.; Ince, N.; Wiedmann, M.; Carter, J.J.; Lahousse, S.A.; Califano, S.; Maeda, T.; Ueno, T.; DErrico, A.; Trevisani, F.; Wands, J.R.
Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness
J. Hepatol.
44
971-983
2006
Homo sapiens
Xian, Z.H.; Zhang, S.H.; Cong, W.M.; Yan, H.X.; Wang, K.; Wu, M.C.
Expression of aspartyl beta-hydroxylase and its clinicopathological significance in hepatocellular carcinoma
Mod. Pathol.
19
280-286
2006
Homo sapiens
Cockman, M.E.; Lancaster, D.E.; Stolze, I.P.; Hewitson, K.S.; McDonough, M.A.; Coleman, M.L.; Coles, C.H.; Yu, X.; Hay, R.T.; Ley, S.C.; Pugh, C.W.; Oldham, N.J.; Masson, N.; Schofield, C.J.; Ratcliffe, P.J.
Posttranslational hydroxylation of ankyrin repeats in IkB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
Proc. Natl. Acad. Sci. USA
103
14767-14772
2006
Homo sapiens
Carter, J.J.; Tong, M.; Silbermann, E.; Lahousse, S.A.; Ding, F.F.; Longato, L.; Roper, N.; Wands, J.R.; de la Monte, S.M.
Ethanol impaired neuronal migration is associated with reduced aspartyl-asparaginyl-beta-hydroxylase expression
Acta Neuropathol.
116
303-315
2008
Homo sapiens
Yeung, Y.A.; Finney, A.H.; Koyrakh, I.A.; Lebowitz, M.S.; Ghanbari, H.A.; Wands, J.R.; Wittrup, K.D.
Isolation and characterization of human antibodies targeting human aspartyl (asparaginyl) beta-hydroxylase
Hum. Antibodies
16
163-176
2007
Homo sapiens
Coleman, M.L.; McDonough, M.A.; Hewitson, K.S.; Coles, C.; Mecinovic, J.; Edelmann, M.; Cook, K.M.; Cockman, M.E.; Lancaster, D.E.; Kessler, B.M.; Oldham, N.J.; Ratcliffe, P.J.; Schofield, C.J.
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor
J. Biol. Chem.
282
24027-24038
2007
Homo sapiens, Mus musculus
de la Monte, S.M.; Tong, M.; Carlson, R.I.; Carter, J.J.; Longato, L.; Silbermann, E.; Wands, J.R.
Ethanol inhibition of aspartyl-asparaginyl-beta-hydroxylase in fetal alcohol spectrum disorder: potential link to the impairments in central nervous system neuronal migration
Alcohol
43
225-240
2009
Rattus norvegicus
Longato, L.; de la Monte, S.; Kuzushita, N.; Horimoto, M.; Rogers, A.B.; Slagle, B.L.; Wands, J.R.
Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver
Hepatology
49
1935-1943
2009
Mus musculus
Luu, M.; Sabo, E.; de la Monte, S.M.; Greaves, W.; Wang, J.; Tavares, R.; Simao, L.; Wands, J.R.; Resnick, M.B.; Wang, L.
Prognostic value of aspartyl (asparaginyl)-beta-hydroxylase/humbug expression in non-small cell lung carcinoma
Hum. Pathol.
40
639-644
2009
Homo sapiens
Xue, T.; Xue, X.P.; Huang, Q.S.; Wei, L.; Sun, K.; Xue, T.
Monoclonal antibodies against human aspartyl (asparaginyl) beta-hydroxylase developed by DNA immunization
Hybridoma
28
251-257
2009
Homo sapiens
Hardy, A.P.; Prokes, I.; Kelly, L.; Campbell, I.D.; Schofield, C.J.
Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function
J. Mol. Biol.
392
994-1006
2009
Homo sapiens
Yang, H.; Wang, H.; Xue, T.; Xue, X.P.; Huyan, T.; Wang, W.; Song, K.
Single-chain variable fragment antibody against human aspartyl/asparaginyl beta-hydroxylase expressed in recombinant Escherichia coli
Hybridoma
30
69-79
2011
Homo sapiens
Lyu, F.; Xue, Q.; Gao, S.
Research progress of aspartyl-(asparaginyl) beta-hydroxylase in tumors
Cancer Res. Clinic
27
280-282
2015
Homo sapiens (Q12797)
-
Yang, H.; Li, J.; Tang, R.; Li, J.; Liu, Y.; Ye, L.; Shao, D.; Jin, M.; Huang, Q.; Shi, J.
The aspartyl (asparaginyl) beta-hydroxylase in carcinomas
Front. Biosci.
20
902-909
2015
Homo sapiens (Q12797), Homo sapiens
Iwagami, Y.; Huang, C.K.; Olsen, M.J.; Thomas, J.M.; Jang, G.; Kim, M.; Lin, Q.; Carlson, R.I.; Wagner, C.E.; Dong, X.; Wands, J.R.
Aspartate beta-hydroxylase modulates cellular senescence through glycogen synthase kinase 3beta in hepatocellular carcinoma
Hepatology
63
1213-1226
2016
Homo sapiens (Q12797)
Huyan, T.; Li, Q.; Ye, L.J.; Yang, H.; Xue, X.P.; Zhang, M.J.; Huang, Q.S.; Yin, D.C.; Shang, P.
Inhibition of human natural killer cell functional activity by human aspartyl alpha-hydroxylase
Int. Immunopharmacol.
23
452-459
2014
Homo sapiens (Q12797)
Borgas, D.L.; Gao, J.S.; Tong, M.; Roper, N.; de la Monte, S.M.
Regulation of aspartyl-(asparaginyl)-?-hydroxylase protein expression and function by phosphorylation in hepatocellular carcinoma cells
J. Nat. Sci.
1
e84
2015
Homo sapiens (Q12797)
Tang, C.; Hou, Y.; Wang, H.; Wang, K.; Xiang, H.; Wan, X.; Xia, Y.; Li, J.; Wei, W.; Xu, S.; Lei, Z.; Pawlik, T.M.; Wang, H.; Wu, M.; Shen, F.
Aspartate beta-hydroxylase disrupts mitochondrial DNA stability and function in hepatocellular carcinoma
Oncogenesis
6
e362
2017
Homo sapiens (Q12797)
Dong, X.; Lin, Q.; Aihara, A.; Li, Y.; Huang, C.K.; Chung, W.; Tang, Q.; Chen, X.; Carlson, R.; Nadolny, C.; Gabriel, G.; Olsen, M.; Wands, J.R.
Aspartate beta-hydroxylase expression promotes a malignant pancreatic cellular phenotype
Oncotarget
6
1231-1248
2015
Homo sapiens (Q12797)
Ma, M.; Hua, S.; Li, G.; Wang, S.; Cheng, X.; He, S.; Wu, P.; Chen, X.
Prolyl hydroxylase domain protein 3 and asparaginyl hydroxylase factor inhibiting HIF-1 levels are predictive of tumoral behavior and prognosis in hepatocellular carcinoma
Oncotarget
8
12983-13002
2017
Homo sapiens (Q9NWT6), Homo sapiens
Tomimaru, Y.; Mishra, S.; Safran, H.; Charpentier, K.P.; Martin, W.; De Groot, A.S.; Gregory, S.H.; Wands, J.R.
Aspartate-beta-hydroxylase induces epitope-specific T cell responses in hepatocellular carcinoma
Vaccine
33
1256-1266
2015
Homo sapiens (Q12797)
Brewitz, L.; Tumber, A.; Zhang, X.; Schofield, C.J.
Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-beta-hydroxylase
Bioorg. Med. Chem.
28
115675
2020
Homo sapiens (Q12797)
Huang, C.K.; Iwagami, Y.; Zou, J.; Casulli, S.; Lu, S.; Nagaoka, K.; Ji, C.; Ogawa, K.; Cao, K.Y.; Gao, J.S.; Carlson, R.I.; Wands, J.R.
Aspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation
Cancer Lett.
429
1-10
2018
Mus musculus (Q8BSY0)
Barboro, P.; Benelli, R.; Tosetti, F.; Costa, D.; Capaia, M.; Astigiano, S.; Vene, R.; Poggi, A.; Ferrari, N.
Aspartate beta-hydroxylase targeting in castration-resistant prostate cancer modulates the NOTCH/HIF1alpha/GSK3beta crosstalk
Carcinogenesis
41
1246-1252
2020
Homo sapiens
Brewitz, L.; Nakashima, Y.; Schofield, C.J.
Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-beta-hydroxylase
Chem. Sci.
12
1327-1342
2020
Homo sapiens (Q12797)
Brewitz, L.; Tumber, A.; Thalhammer, A.; Salah, E.; Christensen, K.E.; Schofield, C.J.
Synthesis of novel pyridine-carboxylates as small-molecule inhibitors of human aspartate/asparagine-beta-hydroxylase
ChemMedChem
15
1139-1149
2020
Homo sapiens (Q12797)
Brewitz, L.; Tumber, A.; Schofield, C.J.
Kinetic parameters of human aspartate/asparagine-beta-hydroxylase suggest that it has a possible function in oxygen sensing
J. Biol. Chem.
295
7826-7838
2020
Homo sapiens (Q12797)
Zhou, Y.; Liu, F.; Li, C.; Shi, G.; Xu, X.; Luo, X.; Zhang, Y.; Fu, J.; Zeng, A.; Chen, L.
Construction and characterization of adenovirus vectors encoding aspartate-beta-hydroxylase to preliminary application in immunotherapy of hepatocellular carcinoma
J. Immunol. Res.
2018
9832467
2018
Homo sapiens (Q12797)
Zhang, Y.; Gao, Y.; Li, Y.; Zhang, X.; Xie, H.
Characterization of the relationship between the expression of aspartate beta-hydroxylase and the pathological characteristics of breast cancer
Med. Sci. Monit.
26
e926752
2020
Homo sapiens (Q12797)
Greve, J.M.; Pinkham, A.M.; Thompson, Z.; Cowan, J.A.
Active site characterization and activity of the human aspartyl (asparaginyl) beta-hydroxylase
Metallomics
13
mfab056
2021
Homo sapiens (Q12797), Homo sapiens
Pfeffer, I.; Brewitz, L.; Krojer, T.; Jensen, S.A.; Kochan, G.T.; Kershaw, N.J.; Hewitson, K.S.; McNeill, L.A.; Kramer, H.; Muenzel, M.; Hopkinson, R.J.; Oppermann, U.; Handford, P.A.; McDonough, M.A.; Schofield, C.J.
Aspartate/asparagine-beta-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
Nat. Commun.
10
4910
2019
Homo sapiens (Q12797)
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