Reference on EC 1.13.11.52 - indoleamine 2,3-dioxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Badawy, A.A.
Central role of tryptophan pyrrolase in haem metabolism
Biochem. Soc. Trans.
7
575-583
1979
Bos taurus, Cavia porcellus, Gallus gallus, Oryctolagus cuniculus, Felis catus, Frog, Meriones unguiculatus, Cricetinae, Ovis aries, Homo sapiens, Meleagris gallopavo, Mus musculus, Rattus norvegicus, Sus scrofa
Feigelson, P.; Brady, F.O.
Heme-containing dioxygenases
Mol. Mech. Oxygen Activ. (Hayaishi, O., ed.) Academic Press, New York
87-133
1974
Delftia acidovorans, Rattus norvegicus
-
Maezono, K.; Tashiro, K.; Nakamura, T.
Deduced primary structure of rat tryptophan-2,3-dioxygenase
Biochem. Biophys. Res. Commun.
170
176-181
1990
Rattus norvegicus, Rattus norvegicus (P21643)
Hitchcock, M.J.M.; Katz, E.
Purification and characterization of tryptophan dioxygenase from Streptomyces parvulus
Arch. Biochem. Biophys.
261
148-160
1988
Streptomyces parvulus
Matsumura, M.; Osada, K.; Aiba, S.
L-Tryptophan 2,3-dioxygenase of a moderate thermophile, Bacillus brevis. Purification, properties and a substrate-mediated stabilization of the quaternary structure
Biochim. Biophys. Acta
786
9-17
1984
Brevibacillus brevis
Uchida, K.; Shimizu, T.; Makino, R.; Sakaguchi, K.; Iizuka, T.; Ishimura, Y.
Magnetic and natural circular dichroism of L-tryptophan 2,3-dioxygenases and indoleamine 2,3-dioxygenase. I. Spectra of ferric and ferrous high spin forms
J. Biol. Chem.
258
2519-2525
1983
Delftia acidovorans, Oryctolagus cuniculus, Rattus norvegicus
Sono, M.
Spectroscopic and equilibrium studies of ligand and organic substrate binding to indolamine 2,3-dioxygenase
Biochemistry
29
1451-1460
1990
Oryctolagus cuniculus
Sono, M.
The roles of superoxide anion and methylene blue in the reductive activation of indoleamine 2,3-dioxygenase by ascorbic acid or by xanthine oxidase-hypoxanthine
J. Biol. Chem.
264
1616-1622
1989
Oryctolagus cuniculus
Yoshida, R.; Hayaishi, O.
Indoleamine 2,3-dioxygenase
Methods Enzymol.
142
188-195
1987
Oryctolagus cuniculus
Sono, M.; Dawson, J.H.
Extensive studies of the heme coordination structure of indoleamine 2,3-dioxygenase and of tryptophan binding with magnetic and natural circular dichroism and electron paramagnetic resonance spectroscopy
Biochim. Biophys. Acta
789
170-187
1984
Oryctolagus cuniculus
Yoshida, R.; Hayaishi, O.
Overview: superoxygenase
Methods Enzymol.
105
61-70
1984
Oryctolagus cuniculus
Shimizu, T.; Nomiyama, S.; Hirata, F.; Hayaishi, O.
Indoleamine 2,3-dioxygenase. Purification and some properties
J. Biol. Chem.
253
4700-4706
1978
Oryctolagus cuniculus
Littlejohn, T.K.; Takikawa, O.; Skylas, D.; Jamie, J.F.; Walker, M.J.; Truscott, R.J.W.
Expression and purification of recombinant human indoleamine 2,3-dioxygenase
Protein Expr. Purif.
19
22-29
2000
Homo sapiens
Salter, M.; Hazelwood, R.; Pogson, C.I.; Iyer, R.; Madge, D.J.
The effects of a novel and selective inhibitor of tryptophan 2,3-dioxygenase on tryptophan and serotonin metabolism in the rat
Biochem. Pharmacol.
49
1435-1442
1995
Rattus norvegicus
Thomas, S.R.; Mohr, D.; Stocker, R.
Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon-gamma primed mononuclear phagocytes
J. Biol. Chem.
269
14457-14464
1994
Homo sapiens
Dang, Y.; Dale, W.E.; Brown, O.R.
Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway
Free Radic. Biol. Med.
28
615-624
2000
Meriones unguiculatus, Rattus norvegicus
Friberg, M.; Jennings, R.; Alsarraj, M.; Dessureault, S.; Cantor, A.; Extermann, M.; Mellor, A.L.; Munn, D.H.; Antonia, S.J.
Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection
Int. J. Cancer
101
151-155
2002
Mus musculus
Hissong, B.D.; Byrne, G.I.; Padilla, M.L.; Carlin, J.M.
Upregulation of interferon-induced indoleamine 2,3-dioxygenase in human macrophage cultures by lipopolysaccharide, muramyl tripeptide, and interleukin-1
Cell. Immunol.
160
264-269
1995
Homo sapiens
Takikawa, O.; Littlejohn, T.K.; Truscott, R.J.W.
Indoleamine 2,3-dioxygenase in the human lens, the first enzyme in the synthesis of UV filters
Exp. Eye Res.
72
271-277
2001
Homo sapiens
Dick, R.; Murray, B.P.; Reid, M.J.; Correia, M.A.
Structure-Function Relationships of Rat Hepatic Tryptophan 2,3-Dioxygenase: Identification of the Putative Heme-Ligating Histidine Residues
Arch. Biochem. Biophys.
392
71-78
2001
Rattus norvegicus
Kudo, Y.; Boyd, C.A.R.; Sargent, I.L.; Redman, C.W.G.
Tryptophan degradation by human placental indoleamine 2,3-dioxygenase regulates lymphocyte proliferation
J. Physiol.
535
207-215
2001
Homo sapiens
Kudo, Y.; Boyd, C.A.R.
Human placental indoleamine 2,3-dioxygenase: cellular localization and characterization of an enzyme preventing fetal rejection
Biochim. Biophys. Acta
1500
119-124
2000
Homo sapiens
Musso, T.; Gusella, G.L.; Brooks, A.; Longo, D.L.; Varesio, L.
Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes
Blood
83
1408-1411
1994
Homo sapiens
Frumento, G.; Rotondo, R.; Tonetti, M.; Damonte, G.; Benatti, U.; Ferrara, G.B.
Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase
J. Exp. Med.
196
459-468
2002
Oryctolagus cuniculus
Terentis, A.C.; Thomas, S.R.; Takikawa, O.; Littlejohn, T.K.; Truscott, R.J.W.; Armstrong, R.S.; Yeh, S.R.; Stocker, R.
The heme environment of recombinant human indoleamine 2,3-dioxygenase: Structural properties and substrate-ligand interactions
J. Biol. Chem.
277
15788-15794
2002
Homo sapiens
Stowell, L.; Morland, J.
The influence of some methodological factors on measurement of tryptophan oxygenase activities in crude homogenates of rat liver
Biochem. J.
209
831-836
1983
Rattus norvegicus
Schmid, W.; Scherer, G.; Danesch, U.; Zentgraf, H.; Matthias, P.; Strange, C.M.; Roewekamp, W.; Schuetz, G.
Isolation and characterization of the rat tryptophan oxygenase gene
EMBO J.
1
1287-1293
1982
Rattus norvegicus
Ishimura, Y.; Makino, R.; Iizuka, T.
Regulatory control and catalytic mechanisms of L-tryptophan 2,3-dioxygenase (pyrrolase)
Adv. Enzyme Regul.
18
291-302
1980
Oryctolagus cuniculus, Pseudomonas sp., Rattus norvegicus
Rouach, H.; Ribiere, C.; Nordmann, J.; Nordmann, R.
In vitro inhibition of rat liver tryptophan oxygenase by 4-hydroxypyrazole
FEBS Lett.
101
149-152
1979
Rattus norvegicus
Hayaishi, O.
Properties and function of indoleamine 2,3-dioxygenase
J. Biochem.
79
13p-21p
1976
Oryctolagus cuniculus
Ren, S.; Liu, H.; Licad, E.; Correia, M.A.
Expression of rat liver tryptophan 2,3-dioxygenase in Escherichia coli: structural and functional characterization of the purified enzyme
Arch. Biochem. Biophys.
333
96-102
1996
Rattus norvegicus
Schartau, W.; Linzen, B.
The tryptophan 2,3-dioxygenase of the blowfly, Protophormia terrae-novae: partial purification and characterization
Hoppe-Seyler's Z. Physiol. Chem.
357
41-49
1976
Protophormia terraenovae
Chen, J.; Matchett, W.H.
Occurrence of N-formylkynurenine in extracts of Neurospora crassa: evidence for the activity of tryptophan pyrrolase
J. Bacteriol.
118
837-843
1974
Neurospora crassa
Brady, F.O.; Feigelson, P.
Photoactivation of pseudomonad L-tryptophan oxygenase by electron ejection from its substrate, L-tryptophan
Arch. Biochem. Biophys.
156
745-750
1973
Delftia acidovorans
Diamond, E.M.; Jedeikin, A.; Kench, J.E.
Purification of tryptophan oxygenase and its interaction with cadmium
Biochem. Biophys. Res. Commun.
52
679-686
1973
Delftia acidovorans
Schutz, G.; Feigelson, P.
Purification and properties of rat liver tryptophan oxygenase
J. Biol. Chem.
247
5327-5332
1972
Rattus norvegicus
Brady, F.O.; Monaco, M.E.; Forman, H.J.; Schutz, G.; Feigelson, P.
On the role of copper in activation of and catalysis by tryptophan-2,3-dioxygenase
J. Biol. Chem.
247
7915-7922
1972
Delftia acidovorans, Rattus norvegicus
Knox, W.E.; Yip, A.; Reshef, L.
L-Tryptophan 2,3-dioxygenase (tryptophan pyrrolase) (rat liver)
Methods Enzymol.
17A
415-421
1970
Rattus norvegicus
-
Schimke, R.T.
L-Tryptophan 2,3-dioxygenase (tryptophan pyrrolase) (rat liver)
Methods Enzymol.
17A
421-428
1970
Rattus norvegicus
-
Ishimura, Y.
L-Tryptophan 2,3-dioxygenase (tryptophan pyrrolase) (Pseudomonas fluorescens)
Methods Enzymol.
17A
429-434
1970
Pseudomonas fluorescens
-
Yamamoto, S.; Hayaishi, O.
Tryptophan 2,3-dioxygenase (tryptophan pyrrolase) (rabbit intestine)
Methods Enzymol.
17A
434-438
1970
Oryctolagus cuniculus
-
Poillon, W.N.; Maeno, H.; Koike, K.; Feigelson, P.
Tryptophan oxygenase of Pseudomonas acidovorans. Purification, composition, and subunit structure
J. Biol. Chem.
244
3447-3456
1969
Delftia acidovorans
Brown, J.N.; Dodgen, C.L.
Fish liver tryptophan pyrrolase: the apparent absence of both hormonal regulation and substrate induction
Biochim. Biophys. Acta
165
463-469
1968
Ictalurus punctatus
Paik, W.K.; Christinzio, M.; Kim, S.
Liver tryptophan pyrrolase activity during thyrosine-induced metamorphosis of Rana catesbeiana
Biochim. Biophys. Acta
167
209-212
1968
Lithobates catesbeianus
Ishiguro, I.; Naito, J.; Saito, K.; Nagamura, Y.
Skin L-tryptophan-2,3-dioxygenase and rat hair growth
FEBS Lett.
329
178-182
1993
Rattus norvegicus
Terness, P.; Bauer, T.M.; Rose, L.; Dufter, C.; Watzlik, A.; Simon, H.; Opelz, G.
Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites
J. Exp. Med.
196
447-457
2002
Homo sapiens
Daya, S.; Anoopkumar-Dukie, S.
Acetaminophen inhibits liver trytophan-2,3-dioxygenase activity with a concomitant rise in brain serotonin levels and a reduction in urinary 5-hydroxyindole acetic acid
Life Sci.
67
235-240
2000
Rattus norvegicus
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Mus musculus (P48776)
Comings, D.E.; Muhleman, D.; Dietz, G.; Sherman, M.; Forest, G.L.
Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat
Genomics
29
390-396
1995
Homo sapiens (P48775)
Serles, L.L.; Ruth, R.S.; Pret, A.M.; Fridell, R.A.; Ali, A.J.
Structure and transcription of the Drosophila melanogaster vermillion gene and several mutant alleles
Mol. Cell. Biol.
10
1423-1431
1990
Drosophila melanogaster (P20351)
Habara-Ohkubo, A.; Takikawa, O.; Yoshida, R.
Cloning and expression of a cDNA encoding mouse indoleamine 2,3-dioxygenase
Gene
105
221-227
1991
Mus musculus (P28776), Mus musculus
Kadoya, A.; Tone, S.; Mareda, H.; Minatogawa, Y.; Kido, R.
Gene structure of human indoleamine 2,3-dioxygenase
Biochem. Biophys. Res. Commun.
189
530-536
1992
Homo sapiens (P14902), Homo sapiens
Dai, W.; Gupta, S.L.
Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA
Biochem. Biophys. Res. Commun.
168
1-8
1990
Homo sapiens (P14902), Homo sapiens
Tone, S.; Takikawa, O.; Habara-Ohkubo, A.; Kadoxa, A.; Yoshida, R.; Kido, R.
Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA
Nucleic Acids Res.
18
367
1990
Homo sapiens (P14902), Homo sapiens
Kwidzinski, E.; Bunse, J.; Kovac, A.D.; Ullrich, O.; Zipp, F.; Nitsch, R.; Bechmann, I.
IDO (indolamine 2,3-dioxygenase) expression and function in the CNS
Adv. Exp. Med. Biol.
527
113-118
2003
Homo sapiens
Takikawa, O.; Truscott, R.J.; Fukao, M.; Miwa, S.
Age-related nuclear cataract and indoleamine 2,3-dioxygenase-initiated tryptophan metabolism in the human lens
Adv. Exp. Med. Biol.
527
277-285
2003
Homo sapiens
Sedlmayr, P.; Semlitsch, M.; Gebru, G.; Karpf, E.; Reich, O.; Tang, T.; Wintersteiger, R.; Takikawa, O.; Dohr, G.
Expression of indoleamine 2,3-dioxygenase in carcinoma of human endometrium and uterine cervix
Adv. Exp. Med. Biol.
527
91-95
2003
Homo sapiens
Ferry, G.; Ubeaud, C.; Lambert, P.H.; Bertin, S.; Coge, F.; Chomarat, P.; Delagrange, P.; Serkiz, B.; Bouchet, J.P.; Truscott, R.J.W.; Boutin, J.A.
Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase
Biochem. J.
388
205-215
2005
Homo sapiens (P48775)
Murdock, D.; Ensley, B.D.; Serdar, C.; Thalen, M.
Construction of metabolic operons catalyzing the de novo biosynthesis of indigo in Escherichia coli
Biotechnology
11
381-385
1993
Pseudomonas putida
Kudo, Y.; Hara, T.; Katsuki, T.; Toyofuku, A.; Katsura, Y.; Takikawa, O.; Fujii, T.; Ohama, K.
Mechanisms regulating the expression of indoleamine 2,3-dioxygenase during decidualization of human endometrium
Hum. Reprod.
19
1222-1230
2004
Homo sapiens
Littlejohn, T.K.; Takikawa, O.; Jamie, J.F.; Walker, M.J.; Truscott, R.J.W.
Production of truncated enzymically active human indoleamine 2,3-dioxygenase using site-directed mutagenesis
Int. Congr. Ser.
1233
157-160
2002
Homo sapiens
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Manandhar, S.P.; Shimada, H.; Nagano, S.; Egawa, T.; Ishimura, Y.
Subunit structure of recombinant rat liver L-tryptophan 2,3-dioxygenase
Int. Congr. Ser.
1233
161-169
2002
Rattus norvegicus
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Littlejohn, T.K.; Takikawa, O.; Truscott, R.J.W.; Walker, M.J.
Asp274 and His346 are essential for heme binding and catalytic function of human indolamine 2,3-dioxygenase
J. Biol. Chem.
278
29525-29531
2003
Homo sapiens
Mellor, A.L.; Baban, B.; Chandler, P.; Marshall, B.; Jhaver, K.; Hansen, A.; Koni, P.A.; Iwashima, M.; Munn, D.H.
Cutting edge: induced indoleamine 2,3-dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion
J. Immunol.
171
1652-1655
2003
Mus musculus
von Bubnoff, D.; Bausinger, H.; Matz, H.; Koch, S.; Hacker, G.; Takikawa, O.; Bieber, T.; Hanau, D.; de la Salle, H.
Human epidermal langerhans cells express the immunoregulatory enzyme indoleamine 2,3-dioxygenase
J. Invest. Dermatol.
123
298-304
2004
Homo sapiens
Kudo, Y.; Boyd, C.A.; Spyropoulou, I.; Redman, C.W.; Takikawa, O.; Katsuki, T.; Hara, T.; Ohama, K.; Sargent, I.L.
Indoleamine 2,3-dioxygenase: distribution and function in the developing human placenta
J. Reprod. Immunol.
61
87-98
2004
Homo sapiens
Ligam, P.; Manuelpillai, U.; Wallace, E.M.; Walker, D.
Localisation of indoleamine 2,3-dioxygenase and kynurenine hydroxylase in the human placenta and decidua: implications for role of the kynurenine pathway in pregnancy
Placenta
26
498-504
2005
Homo sapiens
Austin, C.J.; Mizdrak, J.; Matin, A.; Sirijovski, N.; Kosim-Satyaputra, P.; Willows, R.D.; Roberts, T.H.; Truscott, R.J.; Polekhina, G.; Parker, M.W.; Jamie, J.F.
Optimised expression and purification of recombinant human indoleamine 2,3-dioxygenase
Protein Expr. Purif.
37
392-398
2004
Homo sapiens
Kai, S.; Goto, S.; Tahara, K.; Sasaki, A.; Tone, S.; Kitano, S.
Indolamine 2,3-dioxygenase is necessary for cytolytic activity of natural killer cells
Scand. J. Immunol.
59
177-182
2004
Homo sapiens
Hayaishi, O.
Utilization of superoxide anion by indoleamine oxygenase-catalyzed tryptophan and indoleamine oxidation
Adv. Exp. Med. Biol.
398
285-289
1996
Oryctolagus cuniculus
Ozaki, Y.; Reinhard, J.F., Jr.; Nichol, C.A.
Cofactor activity of dihydroflavin mononucleotide and tetrahydrobiopterin for murine epididymal indoleamine 2,3-dioxygenase
Biochem. Biophys. Res. Commun.
137
1106-1111
1986
Mus musculus
Watanabe, Y.; Fujiwara, M.; Yoshida, R.; Hayaishi, O.
Stereospecificity of hepatic L-tryptophan 2,3-dioxygenase
Biochem. J.
189
393-405
1980
Bos taurus, Capra hircus, Oryctolagus cuniculus, Homo sapiens, Macaca fuscata fuscata, Mus musculus, Pseudomonas fluorescens, Rattus norvegicus, Sus scrofa
Sono, M.; Cady, S.G.
Enzyme kinetic and spectroscopic studies of inhibitor and effector interactions with indoleamine 2,3-dioxygenase. 1. Norharman and 4-phenylimidazole binding to the enzyme as inhibitors and heme ligands
Biochemistry
28
5392-5399
1989
Oryctolagus cuniculus
Sono, M.
Enzyme kinetic and spectroscopic studies of inhibitor and effector interactions with indoleamine 2,3-dioxygenase. 2. Evidence for the existence of another binding site in the enzyme for indole derivative effectors
Biochemistry
28
5400-5407
1989
Oryctolagus cuniculus
Meisel, R.; Zibert, A.; Laryea, M.; Gobel, U.; Daubener, W.; Dilloo, D.
Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation
Blood
103
4619-4621
2004
Homo sapiens
Fuchs, D.; Moller, A.A.; Reibnegger, G.; Werner, E.R.; Werner-Felmayer, G.; Dierich, M.P.; Wachter, H.
Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection
Immunol. Lett.
28
207-211
1991
Human Immunodeficiency Virus
Daubener, W.; Spors, B.; Hucke, C.; Adam, R.; Stins, M.; Kim, K.S.; Schroten, H.
Restriction of Toxoplasma gondii growth in human brain microvascular endothelial cells by activation of indoleamine 2,3-dioxygenase
Infect. Immun.
69
6527-6531
2001
Homo sapiens
Fallarino, F.; Vacca, C.; Orabona, C.; Belladonna, M.L.; Bianchi, R.; Marshall, B.; Keskin, D.B.; Mellor, A.L.; Fioretti, M.C.; Grohmann, U.; Puccetti, P.
Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells
Int. Immunol.
14
65-68
2002
Mus musculus, Mus musculus DBA/2J
Yamamoto, S.; Hayaishi, O.
Tryptophan pyrrolase of rabbit intestine
J. Biol. Chem.
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5260-5266
1967
Oryctolagus cuniculus
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Hirata, F.; Ohnishi, T.; Hayaishi, O.
Indoleamine 2,3-dioxygenase. Characterization and properties of enzyme. O2- complex
J. Biol. Chem.
252
4637-4642
1977
Oryctolagus cuniculus
Takikawa, O.; Yoshida, R.; Kido, R.; Hayaishi, O.
Tryptophan degraadation in mice initiated by indoleamine 2,3-dioxygenase
J. Biol. Chem.
261
3648-3653
1986
Mus musculus
Kobayashi, K.; Hayashi, K.; Sono, M.
Effects of tryptophan and pH on the kinetics of superoxide radical binding to indoleamine 2,3-dioxygenase studied by pulse radiolysis
J. Biol. Chem.
264
15280-15283
1989
Oryctolagus cuniculus
Loh, H.H.; Berg, C.P.
D-Tryptophan pyrrolase activity in the liver and the intestine of the rat
J. Nutr.
102
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1972
Rattus norvegicus
Southan, M.D.; Truscott, R.J.W.; Jamie, J.F.; Pelosi, L.; Walker, M.J.; Maeda, H.; Iwamoto, Y.; Tone, S.
Structural requirements of the competitive binding site of recombinant human indoleamine 2,3-dioxygenase
Med. Chem. Res.
6
343-352
1996
Homo sapiens
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Sedlmayr, P.; Blaschitz, A.; Wintersteiger, R.; Semlitsch, M.; Hammer, A.; MacKenzie, C.R.; Walcher, W.; Reich, O.; Takikawa, O.; Dohr, G.
Localization of indoleamine 2,3-dioxygenase in human female reproductive organs and the placenta
Mol. Hum. Reprod.
8
385-391
2002
Homo sapiens
Roy, E.J.; Takikawa, O.; Kranz, D.M.; Brown, A.R.; Thomas, D.L.
Neuronal localization of indoleamine 2,3-dioxygenase in mice
Neurosci. Lett.
387
95-99
2005
Mus musculus
Yasui, H.; Takai, K.; Yoshida, R.; Hayaishi, O.
Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients
Proc. Natl. Acad. Sci. USA
83
6622-6626
1986
Homo sapiens
Thomas, S.R.; Stocker, R.
Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway
Redox Rep.
4
199-220
1999
Oryctolagus cuniculus, Homo sapiens, Mus musculus
Oda, S.; Sugimoto, H.; Yoshida, T.; Shiro, Y.
Crystallization and preliminary crystallographic studies of human indoleamine 2,3-dioxygenase
Acta Crystallogr. Sect. F
62
221-223
2006
Homo sapiens
Beutelspacher, S.C.; Tan, P.H.; McClure, M.O.; Larkin, D.F.; Lechler, R.I.; George, A.J.
Expression of indoleamine 2,3-dioxygenase (IDO) by endothelial cells: implications for the control of alloresponses
Am. J. Transplant.
6
1320-1330
2006
Homo sapiens
Hu, X.; Bao, Z.; Hu, J.; Shao, M.; Zhang, L.; Bi, K.; Zhan, A.; Huang, X.
Cloning and characterization of tryptophan 2,3-dioxygenase gene of Zhikong scallop Chlamys farreri (Jones and Preston 1904)
Aquac. Res.
37
1187-1194
2006
Azumapecten farreri
Takikawa, O.
Biochemical and medical aspects of the indoleamine 2,3-dioxygenase-initiated L-tryptophan metabolism
Biochem. Biophys. Res. Commun.
338
12-19
2005
Oryctolagus cuniculus, Homo sapiens
Papadopoulou, N.D.; Mewies, M.; McLean, K.J.; Seward, H.E.; Svistunenko, D.A.; Munro, A.W.; Raven, E.L.
Redox and spectroscopic properties of human indoleamine 2,3-dioxygenase and a His303Ala variant: implications for catalysis
Biochemistry
44
14318-14328
2005
Homo sapiens
Samelson-Jones, B.J.; Yeh, S.R.
Interactions between nitric oxide and indoleamine 2,3-dioxygenase
Biochemistry
45
8527-8538
2006
Homo sapiens (P14902), Homo sapiens
Zhang, Y.; Kang, S.A.; Mukherjee, T.; Bale, S.; Crane, B.R.; Begley, T.P.; Ealick, S.E.
Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis
Biochemistry
46
145-155
2007
Cupriavidus metallidurans
Vottero, E.; Balgi, A.; Woods, K.; Tugendreich, S.; Melese, T.; Andersen, R.J.; Mauk, A.G.; Roberge, M.
Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast
Biotechnol. J.
1
282-288
2006
Homo sapiens
von Bergwelt-Baildon, M.S.; Popov, A.; Saric, T.; Chemnitz, J.; Classen, S.; Stoffel, M.S.; Fiore, F.; Roth, U.; Beyer, M.; Debey, S.; Wickenhauser, C.; Hanisch, F.G.; Schultze, J.L.
CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition
Blood
108
228-237
2006
Homo sapiens
Comai, S.; Costa, C.V.; Ragazzi, E.; Bertazzo, A.; Allegri, G.
The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats
Clin. Chim. Acta
360
67-80
2005
Rattus norvegicus
Serbecic, N.; Beutelspacher, S.C.
Indoleamine 2,3-dioxygenase protects corneal endothelial cells from UV mediated damage
Exp. Eye Res.
82
416-426
2006
Mus musculus (P28776), Mus musculus
Comai, S.; Bertazzo, A.; Ragazzi, E.; Caparrotta, L.; Costa, C.V.; Allegri, G.
Influence of age on Cu/Zn-superoxide dismutase and indole 2,3-dioxygenase activities in rat tissues
Ital. J. Biochem.
54
232-239
2006
Rattus norvegicus
Brastianos, H.C.; Vottero, E.; Patrick, B.O.; Van Soest, R.; Matainaho, T.; Mauk, A.G.; Andersen, R.J.
Exiguamine A, an indoleamine-2,3-dioxygenase (IDO) inhibitor isolated from the marine sponge Neopetrosia exigua
J. Am. Chem. Soc.
128
16046-16047
2006
Homo sapiens
Pereira, A.; Vottero, E.; Roberge, M.; Mauk, A.G.; Andersen, R.J.
Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata
J. Nat. Prod.
69
1496-1499
2006
Homo sapiens
Sugimoto, H.; Oda, S.; Otsuki, T.; Hino, T.; Yoshida, T.; Shiro, Y.
Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase
Proc. Natl. Acad. Sci. USA
103
2611-2616
2006
Homo sapiens
Forouhar, F.; Anderson, J.L.; Mowat, C.G.; Vorobiev, S.M.; Hussain, A.; Abashidze, M.; Bruckmann, C.; Thackray, S.J.; Seetharaman, J.; Tucker, T.; Xiao, R.; Ma, L.C.; Zhao, L.; Acton, T.B.; Montelione, G.T.; Chapman, S.K.; Tong, L.
Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase
Proc. Natl. Acad. Sci. USA
104
473-478
2007
Xanthomonas campestris (Q8PDA8), Xanthomonas campestris
Bouknight, R.R.; Sadoff, H.L.
Tryptophan catabolism in Bacillus megaterium
J. Bacteriol.
121
70-76
1975
Priestia megaterium
Mohib, K.; Guan, Q.; Diao, H.; Du, C.; Jevnikar, A.M.
Proapoptotic activity of indoleamine 2,3-dioxygenase expressed in renal tubular epithelial cells
Am. J. Physiol. Renal Physiol.
293
F801-F812
2007
Mus musculus
Austin, C.J.; Astelbauer, F.; Kosim-Satyaputra, P.; Ball, H.J.; Willows, R.D.; Jamie, J.F.; Hunt, N.H.
Mouse and human indoleamine 2,3-dioxygenase display some distinct biochemical and structural properties
Amino Acids
36
99-106
2009
Mus musculus, Homo sapiens (P14902), Homo sapiens
Li, J.S.; Han, Q.; Fang, J.; Rizzi, M.; James, A.A.; Li, J.
Biochemical mechanisms leading to tryptophan 2,3-dioxygenase activation
Arch. Insect Biochem. Physiol.
64
74-87
2007
Aedes aegypti (Q17P71)
Basran, J.; Rafice, S.A.; Chauhan, N.; Efimov, I.; Cheesman, M.R.; Ghamsari, L.; Raven, E.L.
A kinetic, spectroscopic, and redox study of human tryptophan 2,3-dioxygenase
Biochemistry
47
4752-4760
2008
Homo sapiens, Homo sapiens (P48775)
Chauhan, N.; Basran, J.; Efimov, I.; Svistunenko, D.A.; Seward, H.E.; Moody, P.C.; Raven, E.L.
The role of serine 167 in human indoleamine 2,3-dioxygenase: a comparison with tryptophan 2,3-dioxygenase
Biochemistry
47
4761-4769
2008
Homo sapiens, Xanthomonas campestris
Macchiarulo, A.; Nuti, R.; Bellocchi, D.; Camaioni, E.; Pellicciari, R.
Molecular docking and spatial coarse graining simulations as tools to investigate substrate recognition, enhancer binding and conformational transitions in indoleamine-2,3-dioxygenase (IDO)
Biochim. Biophys. Acta
1774
1058-1068
2007
Homo sapiens (P14902)
Metz, R.; Duhadaway, J.B.; Kamasani, U.; Laury-Kleintop, L.; Muller, A.J.; Prendergast, G.C.
Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan
Cancer Res.
67
7082-7087
2007
Homo sapiens
Pertovaara, M.; Raitala, A.; Juonala, M.; Lehtimaeki, T.; Huhtala, H.; Oja, S.S.; Jokinen, E.; Viikari, J.S.; Raitakari, O.T.; Hurme, M.
Indoleamine 2,3-dioxygenase enzyme activity correlates with risk factors for atherosclerosis: the cardiovascular risk in young Finns study
Clin. Exp. Immunol.
148
106-111
2007
Homo sapiens
Torres, M.I.; Lopez-Casado, M.A.; Lorite, P.; Rios, A.
Tryptophan metabolism and indoleamine 2,3-dioxygenase expression in coeliac disease
Clin. Exp. Immunol.
148
419-424
2007
Homo sapiens
Werner, E.R.; Werner-Felmayer, G.
Substrate and cofactor requirements of indoleamine 2,3-dioxygenase in interferon-gamma-treated cells: utilization of oxygen rather than superoxide
Curr. Drug Metab.
8
201-203
2007
Homo sapiens
Okamoto, T.; Tone, S.; Kanouchi, H.; Miyawaki, C.; Ono, S.; Minatogawa, Y.
Transcriptional regulation of indoleamine 2,3-dioxygenase (IDO) by tryptophan and its analogue
Cytotechnology
54
107-113
2007
Mus musculus (P28776), Mus musculus
Jung, I.D.; Lee, C.M.; Jeong, Y.I.; Lee, J.S.; Park, W.S.; Han, J.; Park, Y.M.
Differential regulation of indoleamine 2,3-dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells
FEBS Lett.
581
1449-1456
2007
Mus musculus
Ball, H.J.; Sanchez-Perez, A.; Weiser, S.; Austin, C.J.; Astelbauer, F.; Miu, J.; McQuillan, J.A.; Stocker, R.; Jermiin, L.S.; Hunt, N.H.
Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice
Gene
396
203-213
2007
Homo sapiens (Q6ZQW0), Homo sapiens, Mus musculus (Q8R0V5), Mus musculus
Molano, A.; Illarionov, P.A.; Besra, G.S.; Putterman, C.; Porcelli, S.A.
Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase
Immunol. Lett.
117
81-90
2008
Mus musculus
Paglino, A.; Lombardo, F.; Arca, B.; Rizzi, M.; Rossi, F.
Purification and biochemical characterization of a recombinant Anopheles gambiae tryptophan 2,3-dioxygenase expressed in Escherichia coli
Insect Biochem. Mol. Biol.
38
871-876
2008
Anopheles gambiae
King, N.J.; Thomas, S.R.
Molecules in focus: indoleamine 2,3-dioxygenase
Int. J. Biochem. Cell Biol.
39
2167-2172
2007
Homo sapiens, Mus musculus
Ball, H.J.; Yuasa, H.J.; Austin, C.J.; Weiser, S.; Hunt, N.H.
Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway
Int. J. Biochem. Cell Biol.
41
467-471
2009
Mus musculus, Mus musculus (B1AC39)
Taher, Y.A.; Piavaux, B.J.; Gras, R.; van Esch, B.C.; Hofman, G.A.; Bloksma, N.; Henricks, P.A.; van Oosterhout, A.J.
Indoleamine 2,3-dioxygenase-dependent tryptophan metabolites contribute to tolerance induction during allergen immunotherapy in a mouse model
J. Allergy Clin. Immunol.
121
983-91.e2
2008
Mus musculus
Batabyal, D.; Yeh, S.R.
Human tryptophan dioxygenase: a comparison to indoleamine 2,3-dioxygenase
J. Am. Chem. Soc.
129
15690-15701
2007
Homo sapiens
Chung, L.W.; Li, X.; Sugimoto, H.; Shiro, Y.; Morokuma, K.
Density functional theory study on a missing piece in understanding of heme chemistry: the reaction mechanism for indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase
J. Am. Chem. Soc.
130
12299-12309
2008
Homo sapiens
Thomas, S.R.; Terentis, A.C.; Cai, H.; Takikawa, O.; Levina, A.; Lay, P.A.; Freewan, M.; Stocker, R.
Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide
J. Biol. Chem.
282
23778-23787
2007
Homo sapiens
Yuasa, H.J.; Takubo, M.; Takahashi, A.; Hasegawa, T.; Noma, H.; Suzuki, T.
Evolution of vertebrate indoleamine 2,3-dioxygenases
J. Mol. Evol.
65
705-714
2007
Homo sapiens (P14902), Mus musculus (P28776), Mus musculus, Rattus norvegicus (Q9ERD9)
Liao, M.; Pabarcus, M.K.; Wang, Y.; Hefner, C.; Maltby, D.A.; Medzihradszky, K.F.; Salas-Castillo, S.P.; Yan, J.; Maher, J.J.; Correia, M.A.
Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor
J. Pharmacol. Exp. Ther.
323
979-989
2007
Rattus norvegicus
Larrea, E.; Riezu-Boj, J.I.; Gil-Guerrero, L.; Casares, N.; Aldabe, R.; Sarobe, P.; Civeira, M.P.; Heeney, J.L.; Rollier, C.; Verstrepen, B.; Wakita, T.; Borras-Cuesta, F.; Lasarte, J.J.; Prieto, J.
Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection
J. Virol.
81
3662-3666
2007
Homo sapiens, Pan troglodytes
Corm, S.; Berthon, C.; Imbenotte, M.; Biggio, V.; Lhermitte, M.; Dupont, C.; Briche, I.; Quesnel, B.
Indoleamine 2,3-dioxygenase activity of acute myeloid leukemia cells can be measured from patients sera by HPLC and is inducible by IFN-gamma
Leuk. Res.
33
490-494
2009
Homo sapiens
Sheoran, A.; King, A.; Velasco, A.; Pero, J.M.; Garneau-Tsodikova, S.
Characterization of TioF, a tryptophan 2,3-dioxygenase involved in 3-hydroxyquinaldic acid formation during thiocoraline biosynthesis
Mol. Biosyst.
4
622-628
2008
Micromonospora sp., Micromonospora sp. ML1
Macchiarulo, A.; Camaioni, E.; Nuti, R.; Pellicciari, R.
Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer disease
Amino Acids
37
219-229
2009
Mus musculus, Homo sapiens (P14902)
Thackray, S.J.; Mowat, C.G.; Chapman, S.K.
Exploring the mechanism of tryptophan 2,3-dioxygenase
Biochem. Soc. Trans.
36
1120-1123
2008
Cupriavidus metallidurans, Xanthomonas campestris
Rafice, S.A.; Chauhan, N.; Efimov, I.; Basran, J.; Raven, E.L.
Oxidation of L-tryptophan in biology: a comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase
Biochem. Soc. Trans.
37
408-412
2009
Saccharomyces cerevisiae, Oryctolagus cuniculus, Drosophila melanogaster, Homo sapiens, Mus musculus, Cupriavidus metallidurans, Xanthomonas campestris
Thackray, S.J.; Bruckmann, C.; Anderson, J.L.; Campbell, L.P.; Xiao, R.; Zhao, L.; Mowat, C.G.; Forouhar, F.; Tong, L.; Chapman, S.K.
Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding
Biochemistry
47
10677-10684
2008
Xanthomonas campestris (Q8PDA8), Xanthomonas campestris
Nakashima, H.; Uto, Y.; Nakata, E.; Nagasawa, H.; Ikkyu, K.; Hiraoka, N.; Nakashima, K.; Sasaki, Y.; Sugimoto, H.; Shiro, Y.; Hashimoto, T.; Okamoto, Y.; Asakawa, Y.; Hori, H.
Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2,3-dioxygenase inhibitors
Bioorg. Med. Chem.
16
8661-8669
2008
Homo sapiens
Curti, A.; Trabanelli, S.; Salvestrini, V.; Baccarani, M.; Lemoli, R.M.
The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology
Blood
113
2394-2401
2009
Homo sapiens
Clarke, G.; Fitzgerald, P.; Cryan, J.F.; Cassidy, E.M.; Quigley, E.M.; Dinan, T.G.
Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort
BMC Gastroenterol.
9
6
2009
Homo sapiens
Qian, F.; Villella, J.; Wallace, P.K.; Mhawech-Fauceglia, P.; Tario, J.D.; Andrews, C.; Matsuzaki, J.; Valmori, D.; Ayyoub, M.; Frederick, P.J.; Beck, A.; Liao, J.; Cheney, R.; Moysich, K.; Lele, S.; Shrikant, P.; Old, L.J.; Odunsi, K.
Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2,3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancer
Cancer Res.
69
5498-5504
2009
Homo sapiens
Yuasa, H.J.; Ball, H.J.; Ho, Y.F.; Austin, C.J.; Whittington, C.M.; Belov, K.; Maghzal, G.J.; Jermiin, L.S.; Hunt, N.H.
Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials
Comp. Biochem. Physiol. B
153
137-144
2009
Danio rerio, Mus musculus, Xenopus laevis, Ornithorhynchus anatinus (B3Y9H6), Ornithorhynchus anatinus (B3Y9H7), Monodelphis domestica (B3Y9H8), Monodelphis domestica (B3Y9H9), Monodelphis domestica
Schmidt, S.K.; Mueller, A.; Heseler, K.; Woite, C.; Spekker, K.; MacKenzie, C.R.; Daeubener, W.
Antimicrobial and immunoregulatory properties of human tryptophan 2,3-dioxygenase
Eur. J. Immunol.
39
2755-2764
2009
Homo sapiens
Quan, J.; Tan, P.H.; MacDonald, A.; Friend, P.J.
Manipulation of indoleamine 2,3-dioxygenase (IDO) for clinical transplantation: promises and challenges
Expert. Opin. Biol. Ther.
8
1705-1719
2008
Homo sapiens
Spekker, K.; Czesla, M.; Ince, V.; Heseler, K.; Schmidt, S.K.; Schares, G.; Daeubener, W.
Indoleamine 2,3-dioxygenase is involved in defense against Neospora caninum in human and bovine cells
Infect. Immun.
77
4496-4501
2009
Bos taurus, Homo sapiens
Cherayil, B.J.
Indoleamine 2,3-dioxygenase in intestinal immunity and inflammation
Inflamm. Bowel Dis.
15
1391-1396
2009
Homo sapiens, Mus musculus
Lu, C.; Lin, Y.; Yeh, S.R.
Inhibitory substrate binding site of human indoleamine 2,3-dioxygenase
J. Am. Chem. Soc.
131
12866-12867
2009
Homo sapiens
Fukumura, E.; Sugimoto, H.; Misumi, Y.; Ogura, T.; Shiro, Y.
Cooperative binding of L-trp to human tryptophan 2,3-dioxygenase: resonance Raman spectroscopic analysis
J. Biochem.
145
505-515
2009
Homo sapiens
Nickel, E.; Nienhaus, K.; Lu, C.; Yeh, S.R.; Nienhaus, G.U.
Ligand and substrate migration in human indoleamine 2,3-dioxygenase
J. Biol. Chem.
284
31548-31554
2009
Homo sapiens
Mueller, A.; Heseler, K.; Schmidt, S.K.; Spekker, K.; Mackenzie, C.R.; Daeubener, W.
The missing link between indoleamine 2,3-dioxygenase mediated antibacterial and immunoregulatory effects
J. Cell. Mol. Med.
13
1125-1135
2008
Homo sapiens
Becerra, A.; Warke, R.V.; Xhaja, K.; Evans, B.; Evans, J.; Martin, K.; de Bosch, N.; Rothman, A.L.; Bosch, I.
Increased activity of indoleamine 2,3-dioxygenase in serum from acutely infected dengue patients linked to gamma interferon antiviral function
J. Gen. Virol.
90
810-817
2009
Homo sapiens
Dai, X.; Zhu, B.T.
Indoleamine 2,3-Dioxygenase Tissue Distribution and Cellular Localization in Mice: Implications for Its Biological Functions
J. Histochem. Cytochem.
58
17-28
2009
Mus musculus (P28776), Mus musculus
Chen, W.; Liang, X.; Peterson, A.J.; Munn, D.H.; Blazar, B.R.
The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation
J. Immunol.
181
5396-5404
2008
Homo sapiens
Kumar, S.; Malachowski, W.P.; DuHadaway, J.B.; LaLonde, J.M.; Carroll, P.J.; Jaller, D.; Metz, R.; Prendergast, G.C.; Muller, A.J.
Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors
J. Med. Chem.
51
1706-1718
2008
Homo sapiens (P14902)
Kumar, S.; Jaller, D.; Patel, B.; LaLonde, J.M.; DuHadaway, J.B.; Malachowski, W.P.; Prendergast, G.C.; Muller, A.J.
Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase
J. Med. Chem.
51
4968-4977
2008
Homo sapiens (P14902)
Yue, E.W.; Douty, B.; Wayland, B.; Bower, M.; Liu, X.; Leffet, L.; Wang, Q.; Bowman, K.J.; Hansbury, M.J.; Liu, C.; Wei, M.; Li, Y.; Wynn, R.; Burn, T.C.; Koblish, H.K.; Fridman, J.S.; Metcalf, B.; Scherle, P.A.; Combs, A.P.
Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model
J. Med. Chem.
52
7364-7367
2009
Homo sapiens
Mailankot, M.; Staniszewska, M.M.; Butler, H.; Caprara, M.H.; Howell, S.; Wang, B.; Doller, C.; Reneker, L.W.; Nagaraj, R.H.
Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens
Lab. Invest.
89
498-512
2009
Homo sapiens
Hoshi, M.; Ito, H.; Fujigaki, H.; Takemura, M.; Takahashi, T.; Tomita, E.; Ohyama, M.; Tanaka, R.; Saito, K.; Seishima, M.
Indoleamine 2,3-dioxygenase is highly expressed in human adult T-cell leukemia/lymphoma and chemotherapy changes tryptophan catabolism in serum and reduced activity
Leuk. Res.
33
39-45
2009
Homo sapiens
Mueller, A.C.; Daya, S.
Acyclovir inhibits rat liver tryptophan-2,3-dioxygenase and induces a concomitant rise in brain serotonin and 5-hydroxyindole acetic acid levels
Metab. Brain Dis.
23
351-360
2008
Rattus norvegicus
Zelante, T.; Fallarino, F.; Bistoni, F.; Puccetti, P.; Romani, L.
Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host
Microbes Infect.
11
133-141
2009
Homo sapiens
Kanai, M.; Funakoshi, H.; Takahashi, H.; Hayakawa, T.; Mizuno, S.; Matsumoto, K.; Nakamura, T.
Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice
Mol. Brain
2
8
2009
Mus musculus
Schefold, J.C.; Zeden, J.P.; Fotopoulou, C.; von Haehling, S.; Pschowski, R.; Hasper, D.; Volk, H.D.; Schuett, C.; Reinke, P.
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms
Nephrol. Dial. Transplant.
24
1901-1908
2009
Homo sapiens
Kanai, M.; Nakamura, T.; Funakoshi, H.
Identification and characterization of novel variants of the tryptophan 2,3-dioxygenase gene: differential regulation in the mouse nervous system during development
Neurosci. Res.
64
111-117
2009
Mus musculus
Arefayene, M.; Philips, S.; Cao, D.; Mamidipalli, S.; Desta, Z.; Flockhart, D.A.; Wilkes, D.S.; Skaar, T.C.
Identification of genetic variants in the human indoleamine 2,3-dioxygenase (IDO1) gene, which have altered enzyme activity
Pharmacogenet. Genomics
19
464-476
2009
Homo sapiens (P14902), Homo sapiens
Xu, H.; Oriss, T.B.; Fei, M.; Henry, A.C.; Melgert, B.N.; Chen, L.; Mellor, A.L.; Munn, D.H.; Irvin, C.G.; Ray, P.; Ray, A.
Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation
Proc. Natl. Acad. Sci. USA
105
6690-6695
2008
Mus musculus
Huttunen, R.; Syrjaenen, J.; Aittoniemi, J.; Oja, S.S.; Raitala, A.; Laine, J.; Pertovaara, M.; Vuento, R.; Huhtala, H.; Hurme, M.
High activity of indoleamine 2,3 dioxygenase enzyme predicts disease severity and case fatality in bacteremic patients
Shock
33
149-154
2010
Homo sapiens
Liu, J.; Lu, G.; Tang, F.; Liu, Y.; Cui, G.
Localization of indoleamine 2,3-dioxygenase in human esophageal squamous cell carcinomas
Virchows Arch.
455
441-448
2009
Homo sapiens
Nishizawa, H.; Kato, T.; Ota, S.; Nishiyama, S.; Pryor-Koishi, K.; Suzuki, M.; Tsutsumi, M.; Inagaki, H.; Kurahashi, H.; Udagawa, Y.
Genetic variation in the indoleamine 2,3-dioxygenase gene in pre-eclampsia
Am. J. Reprod. Immunol.
64
68-76
2010
Homo sapiens
Austin, C.J.; Mailu, B.M.; Maghzal, G.J.; Sanchez-Perez, A.; Rahlfs, S.; Zocher, K.; Yuasa, H.J.; Arthur, J.W.; Becker, K.; Stocker, R.; Hunt, N.H.; Ball, H.J.
Biochemical characteristics and inhibitor selectivity of mouse indoleamine 2,3-dioxygenase-2
Amino Acids
39
565-578
2010
Mus musculus
Jung, I.D.; Lee, J.S.; Lee, C.M.; Noh, K.T.; Jeong, Y.I.; Park, W.S.; Chun, S.H.; Jeong, S.K.; Park, J.W.; Son, K.H.; Heo, D.R.; Lee, M.G.; Shin, Y.K.; Kim, H.W.; Yun, C.H.; Park, Y.M.
Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation
Biochem. Pharmacol.
80
491-505
2010
Mus musculus
Yanagisawa, S.; Sugimoto, H.; Shiro, Y.; Ogura, T.
A specific interaction of L-tryptophan with CO of CO-bound indoleamine 2,3-dioxygenase identified by resonance Raman spectroscopy
Biochemistry
49
10081-10088
2010
Homo sapiens
Pearson, J.T.; Siu, S.; Meininger, D.P.; Wienkers, L.C.; Rock, D.A.
In vitro modulation of cytochrome P450 reductase supported indoleamine 2,3-dioxygenase activity by allosteric effectors cytochrome b5 and methylene blue
Biochemistry
49
2647-2656
2010
Homo sapiens (P14902)
Lu, C.; Lin, Y.; Yeh, S.R.
Spectroscopic studies of ligand and substrate binding to human indoleamine 2,3-dioxygenase
Biochemistry
49
5028-5034
2010
Homo sapiens
Matsuno, K.; Takai, K.; Isaka, Y.; Unno, Y.; Sato, M.; Takikawa, O.; Asai, A.
S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase
Bioorg. Med. Chem. Lett.
20
5126-5129
2010
Homo sapiens
Soerensen, R.B.; Hadrup, S.R.; Svane, I.M.; Hjortso, M.C.; Thor Straten, P.; Andersen, M.H.
Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators
Blood
117
2200-2210
2011
Homo sapiens
Juergens, B.; Fuchs, D.; Reichenbach, J.; Heitger, A.
Intact indoleamine 2,3-dioxygenase activity in human chronic granulomatous disease
Clin. Immunol.
137
1-4
2010
Homo sapiens
John, S.; Thangapandian, S.; Sakkiah, S.; Lee, K.W.
Identification of potent virtual leads to design novel indoleamine 2,3-dioxygenase inhibitors: pharmacophore modeling and molecular docking studies
Eur. J. Med. Chem.
45
4004-4012
2010
Homo sapiens (P14902)
Di Pucchio, T.; Danese, S.; De Cristofaro, R.; Rutella, S.
Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds
Expert Opin. Ther. Pat.
20
229-250
2010
Homo sapiens
Matteoli, G.; Mazzini, E.; Iliev, I.D.; Mileti, E.; Fallarino, F.; Puccetti, P.; Chieppa, M.; Rescigno, M.
Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction
Gut
59
595-604
2010
Homo sapiens, Mus musculus
Peng, K.; Monack, D.M.
Indoleamine 2,3-dioxygenase 1 is a lung-specific innate immune defense mechanism that inhibits growth of Francisella tularensis tryptophan auxotrophs
Infect. Immun.
78
2723-2733
2010
Mus musculus
Mailankot, M.; Nagaraj, R.H.
Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human lens epithelial cells: apoptosis through the formation of 3-hydroxykynurenine
Int. J. Biochem. Cell Biol.
42
1446-1454
2010
Homo sapiens
Jiang, G.M.; He, Y.W.; Fang, R.; Zhang, G.; Zeng, J.; Yi, Y.M.; Zhang, S.; Bu, X.Z.; Cai, S.H.; Du, J.
Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels
Int. J. Biochem. Cell Biol.
42
1840-1846
2010
Homo sapiens
Yu, C.J.; Zheng, M.F.; Kuang, C.X.; Huang, W.D.; Yang, Q.
Oren-gedoku-to and its constituents with therapeutic potential in Alzheimers disease inhibit indoleamine 2, 3-dioxygenase activity in vitro
J. Alzheimers Dis.
22
257-266
2010
Homo sapiens
Gupta, R.; Fu, R.; Liu, A.; Hendrich, M.P.
EPR and Moessbauer spectroscopy show inequivalent hemes in tryptophan dioxygenase
J. Am. Chem. Soc.
132
1098-1109
2010
Cupriavidus metallidurans
Chung, L.W.; Li, X.; Sugimoto, H.; Shiro, Y.; Morokuma, K.
ONIOM study on a missing piece in our understanding of heme chemistry: bacterial tryptophan 2,3-dioxygenase with dual oxidants
J. Am. Chem. Soc.
132
11993-12005
2010
Xanthomonas campestris (Q8PDA8), Xanthomonas campestris
Davydov, R.M.; Chauhan, N.; Thackray, S.J.; Anderson, J.L.; Papadopoulou, N.D.; Mowat, C.G.; Chapman, S.K.; Raven, E.L.; Hoffman, B.M.
Probing the ternary complexes of indoleamine and tryptophan 2,3-dioxygenases by cryoreduction EPR and ENDOR spectroscopy
J. Am. Chem. Soc.
132
5494-5500
2010
Homo sapiens, Shewanella oneidensis, Xanthomonas campestris
Tattevin, P.; Monnier, D.; Tribut, O.; Dulong, J.; Bescher, N.; Mourcin, F.; Uhel, F.; Le Tulzo, Y.; Tarte, K.
Enhanced indoleamine 2,3-dioxygenase activity in patients with severe sepsis and septic shock
J. Infect. Dis.
201
956-966
2010
Homo sapiens
Roehrig, U.F.; Awad, L.; Grosdidier, A.; Larrieu, P.; Stroobant, V.; Colau, D.; Cerundolo, V.; Simpson, A.J.; Vogel, P.; Van den Eynde, B.J.; Zoete, V.; Michielin, O.
Rational design of indoleamine 2,3-dioxygenase inhibitors
J. Med. Chem.
53
1172-1189
2010
Homo sapiens (P14902)
Avril, T.; Saikali, S.; Vauleon, E.; Jary, A.; Hamlat, A.; De Tayrac, M.; Mosser, J.; Quillien, V.
Distinct effects of human glioblastoma immunoregulatory molecules programmed cell death ligand-1 (PDL-1) and indoleamine 2,3-dioxygenase (IDO) on tumour-specific T cell functions
J. Neuroimmunol.
225
22-33
2010
Homo sapiens
Fu, X.; Zunich, S.M.; OConnor, J.C.; Kavelaars, A.; Dantzer, R.; Kelley, K.W.
Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures
J. Neuroinflammation
7
43
2010
Mus musculus
Samikkannu, T.; Rao, K.V.; Gandhi, N.; Saxena, S.K.; Nair, M.P.
Human immunodeficiency virus type 1 clade B and C Tat differentially induce indoleamine 2,3-dioxygenase and serotonin in immature dendritic cells: Implications for neuroAIDS
J. NeuroVirol.
16
255-263
2010
Homo sapiens
Mao, R.; Zhang, J.; Jiang, D.; Cai, D.; Levy, J.M.; Cuconati, A.; Block, T.M.; Guo, J.T.; Guo, H.
Indoleamine 2,3-dioxygenase mediates the antiviral effect of gamma interferon against hepatitis B virus in human hepatocyte-derived cells
J. Virol.
85
1048-1057
2011
Homo sapiens (P14902), Homo sapiens
Mouratidis, P.X.; George, A.J.
Transfection of indoleamine 2,3 dioxygenase in primary endothelial cells
Methods Mol. Biol.
616
149-159
2010
Homo sapiens
Orabona, C.; Grohmann, U.
Indoleamine 2,3-dioxygenase and regulatory function: tryptophan starvation and beyond
Methods Mol. Biol.
677
269-280
2011
Homo sapiens
Ohira, K.; Hagihara, H.; Toyama, K.; Takao, K.; Kanai, M.; Funakoshi, H.; Nakamura, T.; Miyakawa, T.
Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus
Mol. Brain
3
26
2010
Mus musculus
Johnson, B.A.; Kahler, D.J.; Baban, B.; Chandler, P.R.; Kang, B.; Shimoda, M.; Koni, P.A.; Pihkala, J.; Vilagos, B.; Busslinger, M.; Munn, D.H.; Mellor, A.L.
B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase
Proc. Natl. Acad. Sci. USA
107
10644-10648
2010
Mus musculus
Kaellberg, E.; Wikstroem, P.; Bergh, A.; Ivars, F.; Leanderson, T.
Indoleamine 2,3-dioxygenase (IDO) activity influence tumor growth in the TRAMP prostate cancer model
Prostate
70
1461-1470
2010
Mus musculus
Capece, L.; Arrar, M.; Roitberg, A.E.; Yeh, S.R.; Marti, M.A.; Estrin, D.A.
Substrate stereo-specificity in tryptophan dioxygenase and indoleamine 2,3-dioxygenase
Proteins
78
2961-2972
2010
Homo sapiens (P14902), Homo sapiens, Xanthomonas campestris (Q8PDA8)
Bonda, D.J.; Mailankot, M.; Stone, J.G.; Garrett, M.R.; Staniszewska, M.; Castellani, R.J.; Siedlak, S.L.; Zhu, X.; Lee, H.G.; Perry, G.; Nagaraj, R.H.; Smith, M.A.
Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimers disease
Redox Rep.
15
161-168
2010
Homo sapiens
Yan, M.L.; Wang, Y.D.; Tian, Y.F.; Lai, Z.D.; Yan, L.N.
Inhibition of allogeneic T-cell response by Kupffer cells expressing indoleamine 2,3-dioxygenase
World J. Gastroenterol.
16
636-640
2010
Mus musculus
Forouzandeh, F.; Jalili, R.B.; Hartwell, R.V.; Allan, S.E.; Boyce, S.; Supp, D.; Ghahary, A.
Local expression of indoleamine 2,3-dioxygenase suppresses T-cell-mediated rejection of an engineered bilayer skin substitute
Wound Repair Regen.
18
614-623
2010
Rattus norvegicus
Fatokun, A.A.; Hunt, N.H.; Ball, H.J.
Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease
Amino Acids
45
1319-1329
2013
Homo sapiens, Mus musculus
Capece, L.; Lewis-Ballester, A.; Marti, M.A.; Estrin, D.A.; Yeh, S.R.
Molecular basis for the substrate stereoselectivity in tryptophan dioxygenase
Biochemistry
50
10910-10918
2011
Homo sapiens, Xanthomonas campestris
Meininger, D.; Zalameda, L.; Liu, Y.; Stepan, L.P.; Borges, L.; McCarter, J.D.; Sutherland, C.L.
Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors
Biochim. Biophys. Acta
1814
1947-1954
2011
Homo sapiens (F5H5G0), Homo sapiens (P14902), Homo sapiens
Huang, Q.; Zheng, M.; Yang, S.; Kuang, C.; Yu, C.; Yang, Q.
Structure-activity relationship and enzyme kinetic studies on 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase (IDO) inhibitors
Eur. J. Med. Chem.
46
5680-5687
2011
Homo sapiens
Reniers, J.; Meinguet, C.; Moineaux, L.; Masereel, B.; Vincent, S.P.; Frederick, R.; Wouters, J.
Synthesis and inhibition study of monoamine oxidase, indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by 3,8-substituted 5H-indeno[1,2-c]pyridazin-5-one derivatives
Eur. J. Med. Chem.
46
6104-6111
2011
Cupriavidus metallidurans
Eleftheriadis, T.; Pissas, G.; Karioti, A.; Antoniadi, G.; Liakopoulos, V.; Dafopoulou, K.; Pournaras, S.; Koukoulis, G.; Stefanidis, I.
The indoleamine 2,3-dioxygenase inhibitor 1-methyl-tryptophan suppresses mitochondrial function, induces aerobic glycolysis and decreases interleukin-10 production in human lymphocytes
Immunol. Invest.
41
507-520
2012
Homo sapiens
Fu, R.; Gupta, R.; Geng, J.; Dornevil, K.; Wang, S.; Zhang, Y.; Hendrich, M.P.; Liu, A.
Enzyme reactivation by hydrogen peroxide in heme-based tryptophan dioxygenase
J. Biol. Chem.
286
26541-26554
2011
Cupriavidus metallidurans
Freewan, M.; Rees, M.D.; Plaza, T.S.; Glaros, E.; Lim, Y.J.; Wang, X.S.; Yeung, A.W.; Witting, P.K.; Terentis, A.C.; Thomas, S.R.
Human indoleamine 2,3-dioxygenase is a catalyst of physiological heme peroxidase reactions: implications for the inhibition of dioxygenase activity by hydrogen peroxide
J. Biol. Chem.
288
1548-1567
2013
Homo sapiens
Huang, W.; Gong, Z.; Li, J.; Ding, J.
Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase reveals insights into substrate recognition and catalytic mechanism
J. Struct. Biol.
181
291-299
2013
Drosophila melanogaster (P20351)
Jackman, K.A.; Brait, V.H.; Wang, Y.; Maghzal, G.J.; Ball, H.J.; McKenzie, G.; De Silva, T.M.; Stocker, R.; Sobey, C.G.
Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice
Naunyn Schmiedebergs Arch. Pharmacol.
383
471-481
2011
Mus musculus
Wu, W.; Nicolazzo, J.A.; Wen, L.; Chung, R.; Stankovic, R.; Bao, S.S.; Lim, C.K.; Brew, B.J.; Cullen, K.M.; Guillemin, G.J.
Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimers disease brain
PLoS ONE
8
e59749
2013
Homo sapiens, Mus musculus
Kuo, H.H.; Mauk, A.G.
Indole peroxygenase activity of indoleamine 2,3-dioxygenase
Proc. Natl. Acad. Sci. USA
109
13966-13971
2012
Homo sapiens
Pantouris, G.; Serys, M.; Yuasa, H.J.; Ball, H.J.; Mowat, C.G.
Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1
Amino Acids
46
2155-2163
2014
Homo sapiens (P14902), Homo sapiens (Q6ZQW0), Homo sapiens
Kolawole, A.O.; Hixon, B.P.; Dameron, L.S.; Chrisman, I.M.; Smirnov, V.V.
Catalytic activity of human indoleamine 2,3-dioxygenase (hIDO1) at low oxygen
Arch. Biochem. Biophys.
570
47-57
2015
Homo sapiens (P14902), Homo sapiens
Alvarez, L.; Lewis-Ballester, A.; Roitberg, A.; Estrin, D.A.; Yeh, S.R.; Marti, M.A.; Capece, L.
Structural study of a flexible active site loop in human indoleamine 2,3-dioxygenase and its functional implications
Biochemistry
55
2785-2793
2016
Homo sapiens (P14902), Homo sapiens
Nienhaus, K.; Nickel, E.; Nienhaus, G.U.
Substrate binding in human indoleamine 2,3-dioxygenase 1 a spectroscopic analysis
Biochim. Biophys. Acta
1865
453-463
2017
Homo sapiens (P14902), Homo sapiens
Cheng, M.F.; Hung, M.S.; Song, J.S.; Lin, S.Y.; Liao, F.Y.; Wu, M.H.; Hsiao, W.; Hsieh, C.L.; Wu, J.S.; Chao, Y.S.; Shih, C.; Wu, S.Y.; Ueng, S.H.
Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors
Bioorg. Med. Chem. Lett.
24
3403-3406
2014
Homo sapiens (P14902)
Maeta, A.; Sano, M.; Fukuwatari, T.; Funakoshi, H.; Nakamura, T.; Shibata, K.
Contributions of tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase to the conversion of D-tryptophan to nicotinamide analyzed by using tryptophan 2,3-dioxygenase-knockout mice
Biosci. Biotechnol. Biochem.
78
878-881
2014
Mus musculus (P28776), Mus musculus C57BL/6 (P28776)
Tomek, P.; Palmer, B.D.; Flanagan, J.U.; Sun, C.; Raven, E.L.; Ching, L.M.
Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) probing the active site-inhibitor interactions
Eur. J. Med. Chem.
126
983-996
2017
Homo sapiens (P14902)
Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I.
Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells
Immunology
146
292-300
2015
Homo sapiens (P14902), Homo sapiens
Eleftheriadis, T.; Pissas, G.; Sounidaki, M.; Tsogka, K.; Antoniadis, N.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I.
Indoleamine 2,3-dioxygenase, by degrading L-tryptophan, enhances carnitine palmitoyltransferaseI activity and fatty acid oxidation, and exerts fatty acid-dependent effects in human alloreactive CD4+ T-cells
Int. J. Mol. Med.
38
1605-1613
2016
Homo sapiens (P14902), Homo sapiens
Booth, E.S.; Basran, J.; Lee, M.; Handa, S.; Raven, E.L.
Substrate oxidation by indoleamine 2,3-dioxygenase evidence for a common reaction mechanism
J. Biol. Chem.
290
30924-30930
2015
Homo sapiens (P14902)
Yuasa, H.J.; Ball, H.J.
Efficient tryptophan-catabolizing activity is consistently conserved through evolution of TDO enzymes, but not IDO enzymes
J. Exp. Zool. B
324
128-140
2015
Strongylocentrotus purpuratus, Xenopus laevis (A2BD60), Nematostella vectensis (A7SDW8), Monosiga brevicollis (A9UVU0), Danio rerio (B0V1K8), Branchiostoma floridae (C3Y9Y8), Homo sapiens (P14902), Mus musculus (P28776), Mus musculus (Q8R0V5), Haliotis diversicolor (Q6F3I3)
Wu, J.S.; Lin, S.Y.; Liao, F.Y.; Hsiao, W.C.; Lee, L.C.; Peng, Y.H.; Hsieh, C.L.; Wu, M.H.; Song, J.S.; Yueh, A.; Chen, C.H.; Yeh, S.H.; Liu, C.Y.; Lin, S.Y.; Yeh, T.K.; Hsu, J.T.; Shih, C.; Ueng, S.H.; Hung, M.S.; Wu, S.Y.
Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening
J. Med. Chem.
58
7807-7819
2015
Homo sapiens (P14902)
Li, R.; Li, H.; Sun, Q.; Liu, L.; Zhang, C.; Ren, X.
Indoleamine 2,3-dioxygenase regulates T cell activity through Vav1/Rac pathway
Mol. Immunol.
81
102-107
2017
Homo sapiens (P14902), Homo sapiens
Gonzalez Esquivel, D.; Ramirez-Ortega, D.; Pineda, B.; Castro, N.; Rios, C.; Perez de la Cruz, V.
Kynurenine pathway metabolites and enzymes involved in redox reactions
Neuropharmacology
112
331-345
2017
Homo sapiens (P14902), Homo sapiens (Q6ZQW0), Mus musculus (P28776)
Yamamoto, R.; Yamamoto, Y.; Imai, S.; Fukutomi, R.; Ozawa, Y.; Abe, M.; Matuo, Y.; Saito, K.
Effects of various phytochemicals on indoleamine 2,3-dioxygenase 1 activity galanal is a novel, competitive inhibitor of the enzyme
PLoS ONE
9
e88789
2014
Homo sapiens (P14902), Homo sapiens
Costabile, M.; Bassal, N.K.; Gerber, J.P.; Hughes, B.P.
Inhibition of indoleamine 2,3-dioxygenase activity by fatty acids and prostaglandins A structure function analysis
Prostaglandins Leukot. Essent. Fatty Acids
122
7-15
2017
Homo sapiens
Yuasa, H.; Sugiura, M.; Harumoto, T.
A single amino acid residue regulates the substrate affinity and specificity of indoleamine 2,3-dioxygenase
Arch. Biochem. Biophys.
640
1-9
2018
Blepharisma stoltei, Blepharisma stoltei (A0A286T905), Blepharisma stoltei (A0A286TA52)
Lin, S.Y.; Yeh, T.K.; Song, J.S.; Hung, M.S.; Cheng, M.F.; Liao, F.Y.; Li, A.S.; Cheng, S.Y.; Lin, L.M.; Chiu, C.H.; Wu, M.H.; Lin, Y.J.; Hsiao, W.; Sun, M.; Wang, Y.H.; Huang, C.H.; Tang, Y.C.; Chang, H.H.; Huang, Z.T.; Chao, Y.S.; Shih, C.; Pan, S.L.; Wu, S.Y.; Kuo, C.C.; Ueng, S.H.
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy
Bioorg. Chem.
77
600-607
2018
Homo sapiens (P14902)
Balti, M.; Plas, A.; Meinguet, C.; Haufroid, M.; Themans, Q.; Efrit, M.L.; Wouters, J.; Lanners, S.
Synthesis of 4- and 5-arylthiazolinethiones as inhibitors of indoleamine 2,3-dioxygenase
Bioorg. Med. Chem. Lett.
27
3607-3610
2017
Homo sapiens (P14902), Homo sapiens
Markwalder, J.A.; Seitz, S.P.; Blat, Y.; Elkin, L.; Hunt, J.T.; Pabalan, J.G.; Jure-Kunkel, M.N.; Vite, G.D.; Covello, K.
Identification and optimization of a novel series of indoleamine 2,3-dioxygenase inhibitors
Bioorg. Med. Chem. Lett.
27
582-585
2017
Homo sapiens (P14902)
Griglio, A.; Torre, E.; Serafini, M.; Bianchi, A.; Schmid, R.; Coda Zabetta, G.; Massarotti, A.; Sorba, G.; Pirali, T.; Fallarini, S.
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors Synthesis, biological investigation and docking studies
Bioorg. Med. Chem. Lett.
28
651-657
2018
Homo sapiens (P14902)
Williams, D.K.; Markwalder, J.A.; Balog, A.J.; Chen, B.; Chen, L.; Donnell, J.; Haque, L.; Hart, A.C.; Mandal, S.K.; Nation, A.; Shan, W.; Vite, G.D.; Covello, K.; Hunt, J.T.; Jure-Kunkel, M.N.; Seitz, S.P.
Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
Bioorg. Med. Chem. Lett.
28
732-736
2018
Homo sapiens (P14902), Homo sapiens
Kong, K.M.; Zhang, J.W.; Liu, B.Z.; Meng, G.R.; Zhang, Q.
Discovery of 5-(pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
Bioorg. Med. Chem. Lett.
30
126901
2020
Homo sapiens (P14902)
Li, Y.; Zhang, S.; Wang, R.; Cui, M.; Liu, W.; Yang, Q.; Kuang, C.
Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase
Bioorg. Med. Chem. Lett.
30
127159
2020
Homo sapiens (P14902)
Yanagisawa, S.; Kayama, K.; Hara, M.; Sugimoto, H.; Shiro, Y.; Ogura, T.
UV Resonance Raman characterization of a substrate bound to human indoleamine 2,3-dioxygenase 1
Biophys. J.
117
706-716
2019
Homo sapiens (P14902)
Klar, R.; Michel, S.; Schell, M.; Hinterwimmer, L.; Zippelius, A.; Jaschinski, F.
A highly efficient modality to block the degradation of tryptophan for cancer immunotherapy locked nucleic acid-modified antisense oligonucleotides to inhibit human indoleamine 2,3-dioxygenase 1/tryptophan 2,3-dioxygenase expression
Cancer Immunol. Immunother.
69
57-67
2020
Homo sapiens (P14902), Homo sapiens
Xu, H.; Song, Y.; Yang, Q.
A novel high throughput virtual screening protocol to discover new indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
Chem. Pharm. Bull.
65
714-717
2017
Homo sapiens (P14902)
Cui, Z.W.; Zhang, X.Y.; Zhang, X.J.; Wu, N.; Lu, L.F.; Li, S.; Chen, D.D.; Zhang, Y.A.
Molecular and functional characterization of the indoleamine 2,3-dioxygenase in grass carp (Ctenopharyngodon idella)
Fish Shellfish Immunol.
89
301-308
2019
Ctenopharyngodon idella (A0A4D5XKZ6), Ctenopharyngodon idella
Kwon, M.; Ko, S.K.; Jang, M.; Kim, G.H.; Ryoo, I.J.; Son, S.; Ryu, H.W.; Oh, S.R.; Lee, W.K.; Kim, B.Y.; Jang, J.H.; Ahn, J.S.
Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity
J. Enzyme Inhib. Med. Chem.
34
1481-1488
2019
Homo sapiens (P14902)
Roehrig, U.F.; Reynaud, A.; Majjigapu, S.R.; Vogel, P.; Pojer, F.; Zoete, V.
Inhibition mechanisms of indoleamine 2,3-dioxygenase 1 (IDO1)
J. Med. Chem.
62
8784-8795
2019
Homo sapiens (P14902)
Peng, Y.H.; Liao, F.Y.; Tseng, C.T.; Kuppusamy, R.; Li, A.S.; Chen, C.H.; Fan, Y.S.; Wang, S.Y.; Wu, M.H.; Hsueh, C.C.; Chang, J.Y.; Lee, L.C.; Shih, C.; Shia, K.S.; Yeh, T.K.; Hung, M.S.; Kuo, C.C.; Song, J.S.; Wu, S.Y.; Ueng, S.H.
Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-dioxygenase inhibitors
J. Med. Chem.
63
1642-1659
2020
Homo sapiens (P14902)
Serafini, M.; Torre, E.; Aprile, S.; Grosso, E.D.; Gesu, A.; Griglio, A.; Colombo, G.; Travelli, C.; Paiella, S.; Adamo, A.; Orecchini, E.; Coletti, A.; Pallotta, M.T.; Ugel, S.; Massarotti, A.; Pirali, T.; Fallarini, S.
Discovery of highly potent benzimidazole derivatives as indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors from structure-based virtual screening to in vivo pharmacodynamic activity
J. Med. Chem.
63
3047-3065
2020
Mus musculus (P28776)
Ning, X.L.; Li, Y.Z.; Huo, C.; Deng, J.; Gao, C.; Zhu, K.R.; Wang, M.; Wu, Y.X.; Yu, J.L.; Ren, Y.L.; Luo, Z.Y.; Li, G.; Chen, Y.; Wang, S.Y.; Peng, C.; Yang, L.L.; Wang, Z.Y.; Wu, Y.; Qian, S.; Li, G.B.
X-ray structure-guided discovery of a potent, orally bioavailable, dual human indoleamine/tryptophan 2,3-dioxygenase (hIDO/hTDO) inhibitor that shows activity in a mouse model of Parkinsons disease
J. Med. Chem.
64
8303-8332
2021
Homo sapiens (P14902), Homo sapiens
Bando, H.; Lee, Y.; Sakaguchi, N.; Pradipta, A.; Ma, J.S.; Tanaka, S.; Cai, Y.; Liu, J.; Shen, J.; Nishikawa, Y.; Sasai, M.; Yamamoto, M.
Inducible nitric oxide synthase is a key host factor for Toxoplasma GRA15-dependent disruption of the gamma interferon-induced antiparasitic human response
mBio
9
e01738-18
2018
Homo sapiens (P14902)
Zhao, H.; Sun, P.; Guo, W.; Wang, Y.; Zhang, A.; Meng, L.; Ding, C.
Discovery of indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitors based on ortho-naphthaquinone-containing natural product
Molecules
24
1059
2019
Homo sapiens (P14902)
Sari, S.; Tomek, P.; Leung, E.; Reynisson, J.
Discovery and characterisation of dual inhibitors of tryptophan 2,3-dioxygenase (TDO2) and indoleamine 2,3-dioxygenase 1 (IDO1) using virtual screening
Molecules
24
4346
2019
Homo sapiens (P14902)
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