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Information on EC 1.13.11.5 - homogentisate 1,2-dioxygenase and Organism(s) Arabidopsis thaliana and UniProt Accession Q9ZRA2

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EC Tree
IUBMB Comments
Requires Fe2+.
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q9ZRA2
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The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
homogentisate 1,2-dioxygenase, homogentisic acid oxidase, homogentisate dioxygenase, homogentisate 1,2 dioxygenase, elhdo, homogentisate oxidase, homogentisic acid 1,2-dioxygenase, homogentisate oxygenase, homogentisate phytyl-transferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homogentisate dioxygenase
-
HGO
-
-
-
-
homogentisate dioxygenase
-
-
-
-
homogentisate oxidase
-
-
-
-
homogentisate oxygenase
-
-
-
-
homogentisic acid oxidase
-
-
-
-
homogentisic acid oxygenase
-
-
-
-
homogentisic oxygenase
-
-
-
-
homogentisicase
-
-
-
-
HTO
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
Requires Fe2+.
CAS REGISTRY NUMBER
COMMENTARY hide
9029-49-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
homogentisate + O2
4-maleylacetoacetate
show the reaction diagram
-
-
-
ir
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.031
homogentisate
in the absence of ascorbate and Fe2+
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HGD_ARATH
461
0
51455
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
199000
gel filtration
49750
4 * 49750, gel filtration
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tetramer
4 * 49750, gel filtration
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, 20 mM Tris-Cl pH 7.8, 0.5 M NaCl, 0.3 M imidazole, 24 h, loses two third of its activity
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
nickel chelate affinity chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dixon, D.P.; Edwards, R.
Enzymes of tyrosine catabolism in Arabidopsis thaliana
Plant Sci.
171
360-366
2006
Arabidopsis thaliana (Q9ZRA2), Arabidopsis thaliana
Manually annotated by BRENDA team