Reference on EC 1.13.11.20 - cysteine dioxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hosokawa, Y.; Matsumoto, A.; Oka, J.; Itakura, H.; Yamaguchi, K.
Isolation and characterization of a cDNA for rat liver cysteine dioxygenase
Biochem. Biophys. Res. Commun.
168
473-478
1990
BRENDA: Rattus norvegicus
Textmining: Rattus, Mammalia
Yamaguchi, K.; Hosokawa, Y.
Cysteine dioxygenase
Methods Enzymol.
143
395-403
1987
Rattus norvegicus
Kumar, V.; Maresca, B.; Sacco, M.; Goewert, R.; Kobayashi, G.S.; Medoff, G.
Purification and characterization of a cysteine dioxygenase from the yeast phase of Histoplasma capsulatum
Biochemistry
22
762-768
1983
BRENDA: Histoplasma capsulatum
Textmining: Saccharomyces cerevisiae
Lombardini, J.B.; Singer, T.P.; Boyer, P.D.
Cystein oxygenase. II. Studies on the mechanism of the reaction with 18oxygen
J. Biol. Chem.
244
1172-1175
1969
Rattus norvegicus
Kohashi, N.; Yamaguchi, K.; Hosokawa, Y.; Kori, Y.; Fujii, O.; Ueda, I.
Dietary control of cysteine dioxygenase in rat liver
J. Biochem.
84
159-168
1978
BRENDA: Rattus norvegicus
Textmining: Rattus
Sakakibara, S.; Yamaguchi, K.; Hosokawa, Y.; Kohashi, N.; Ueda, I.; Sakamoto, Y.
Purification and some properties of rat liver cysteine oxidase (cysteine dioxygenase)
Biochim. Biophys. Acta
422
273-279
1976
BRENDA: Rattus norvegicus
Textmining: Rattus
Sakakibara, S.; Yamaguchi, K.; Ueda, I.
Two components of cysteine oxidase in rat liver
Biochem. Biophys. Res. Commun.
52
1093-1099
1973
BRENDA: Rattus norvegicus
Textmining: Rattus
Yamaguchi, K.; Hosokawa, Y.; Kohashi, N.; Kori, Y.; Sakakibara, S.; Ueda, I.
Rat liver cysteine dioxygenase (cysteine oxidase). Further purification, characterization, and analysis of the activation and inactivation
J. Biochem.
83
479-491
1978
BRENDA: Rattus norvegicus
Textmining: Rattus
Bagley, P.J.; Stipanuk, M.H.
The activities of rat hepatic cysteine dioxygenase and cysteinesulfinate decarboxylase are regulated in a reciprocal manner in response to dietary casein level
J. Nutr.
124
2410-2421
1994
BRENDA: Rattus norvegicus
Textmining: Rattus
McCann, K.P.; Akbari, M.T.; Williams, A.C.; Ramsden, D.B.
Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA
Biochim. Biophys. Acta
1209
107-110
1994
BRENDA: Homo sapiens, Rattus norvegicus
Textmining: Rattus
Bagley, P.J.; Stipanuk, M.H.
Rats fed a low protein diet supplemented with sulfur amino acids have increased cysteine dioxygenase activity and increased taurine production in hepatocytes
J. Nutr.
125
933-940
1995
BRENDA: Rattus norvegicus
Textmining: Rattus
Bagley, P.J.; Hirschberger, L.L.; Stipanuk, M.H.
Evaluation and modification of an assay procedure for cysteine dioxygenase activity: high-performance liquid chromatography method for measurement of cysteine sulfinate and demonstration of physiological relevance of cysteine dioxygenase activity in cysteine catabolism
Anal. Biochem.
227
40-48
1995
BRENDA: Rattus norvegicus
Textmining: Rattus
Parsons, R.B.; Ramsden, D.B.; Waring, R.H.; Barber, P.C.; Williams, A.C.
Hepatic localization of rat cysteine dioxygenase
J. Hepatol.
29
595-602
1998
BRENDA: Rattus norvegicus
Textmining: Rattus
Kwon, Y.H.; Stipanuk, M.H.
Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes
Am. J. Physiol. Endocrinol. Metab.
280
E804-815
2001
BRENDA: Rattus norvegicus
Textmining: Rattus
Parsons, R.B.; Waring, R.H.; Williams, A.C.; Ramsden, D.B.
Cysteine dioxygenase: regional localization of protein and mRNA in rat brain
J. Neurosci. Res.
65
78-84
2001
BRENDA: Rattus norvegicus
Textmining: Rattus, Ovis aries, Hippocampus
Hirschberger, L.L.; Daval, S.; Stover, P.J.; Stipanuk, M.H.
Murine cysteine dioxygenase gene: structural organization, tissue-specific expression and promoter identification
Gene
277
153-161
2001
BRENDA: Mus musculus (P60334), Mus musculus
Textmining: Homo sapiens, Rattus
Wilkinson, L.J.; Waring, R.H.
Cysteine dioxygenase: modulation of expression in human cell lines by cytokines and control of sulphate production
Toxicol. In Vitro
16
481-483
2002
Homo sapiens
Eppler, B.; Dawson, R.Jr.
Cysteine sulfinate decarboxylase and cysteine dioxygenase activities do not correlate with strain-specific changes in hepatic and cerebellar taurine content in aged rats
Mech. Ageing Dev.
110
57-72
1999
Metazoa, Rattus
Stipanuk, M.H.; Hirschberger, L.L.; Londono, M.P.; Cresenzi, C.L.; Yu, A.F.
The ubiquitin-proteasome system is responsible for cysteine-responsive regulation of cysteine dioxygenase concentration in liver
Am. J. Physiol.
286
E439-448
2004
BRENDA: Rattus norvegicus
Textmining: Metazoa, Homo sapiens, Rattus
Stipanuk, M.H.; Londono, M.; Hirschberger, L.L.; Hickey, C.; Thiel, D.J.; Wang, L.
Evidence for expression of a single distinct form of mammalian cysteine dioxygenase
Amino Acids
26
99-106
2004
BRENDA: Rattus norvegicus
Textmining: Oryctolagus cuniculus, Rattus
Satsu, H.; Terasawa, E.; Hosokawa, Y.; Shimizu, M.
Functional characterization and regulation of the taurine transporter and cysteine dioxygenase in human hepatoblastoma HepG2 cells
Biochem. J.
375
441-447
2003
Homo sapiens
Chai, S.C.; Jerkins, A.A.; Banik, J.J.; Shalev, I.; Pinkham, J.L.; Uden, P.C.; Maroney, M.J.
Heterologous expression, purification, and characterization of recombinant rat cysteine dioxygenase
J. Biol. Chem.
280
9865-9869
2005
BRENDA: Rattus norvegicus
Textmining: Rattus, Escherichia coli
Cresenzi, C.L.; Lee, J.I.; Stipanuk, M.H.
Cysteine is the metabolic signal responsible for dietary regulation of hepatic cysteine dioxygenase and glutamate cysteine ligase in intact rats
J. Nutr.
133
2697-2702
2003
BRENDA: Rattus norvegicus
Textmining: Rattus, collection
Millard, J.; Parsons, R.B.; Waring, R.H.; Williams, A.C.; Ramsden, D.B.
Expression of cysteine dioxygenase (EC 1.13.11.20) and sulfite oxidase in the human lung: a potential role for sulfate production in the protection from airborne xenobiotica
Mol. Pathol.
56
270-274
2003
Homo sapiens
Dominy, J.E.; Simmons, C.R.; Karplus, P.A.; Gehring, A.M.; Stipanuk, M.H.
Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria
J. Bacteriol.
188
5561-5569
2006
BRENDA: no activity in Nostoc sp., Bacillus subtilis (O32085), Bacillus subtilis, Streptomyces coelicolor (O50490), Streptomyces coelicolor (Q9KZL0), Rattus norvegicus (P21816), Bacillus cereus (Q81CX4), Bacillus cereus, Streptomyces coelicolor A3(2) SCO3035 (Q9KZL0), Bacillus cereus DSM 31 (Q81CX4), Streptomyces coelicolor A3(2) SCO5772 (O50490)
Textmining: Fungi, Metazoa, Bacteria, Proteobacteria, Firmicutes, Rattus, Streptomyces coelicolor A3(2), Actinobacteria, Phyla
Chai, S.C.; Bruyere, J.R.; Maroney, M.J.
Probes of the catalytic site of cysteine dioxygenase
J. Biol. Chem.
281
15774-15779
2006
BRENDA: Rattus norvegicus
Textmining: Rattus
Simmons, C.R.; Liu, Q.; Huang, Q.; Hao, Q.; Begley, T.P.; Karplus, P.A.; Stipanuk, M.H.
Crystal structure of mammalian cysteine dioxygenase. A novel mononuclear iron center for cysteine thiol oxidation
J. Biol. Chem.
281
18723-18733
2006
BRENDA: Rattus norvegicus (P21816)
Textmining: Mus musculus, Rattus
Ye, S.; Wu, X.; Wei, L.; Tang, D.; Sun, P.; Bartlam, M.; Rao, Z.
An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor
J. Biol. Chem.
282
3391-3402
2007
BRENDA: Homo sapiens (Q16878), Homo sapiens
Textmining: Mus musculus, Rattus
McCoy, J.G.; Bailey, L.J.; Bitto, E.; Bingman, C.A.; Aceti, D.J.; Fox, B.G.; Phillips, G.N.
Structure and mechanism of mouse cysteine dioxygenase
Proc. Natl. Acad. Sci. USA
103
3084-3089
2006
BRENDA: Mus musculus (P60334), Mus musculus
Textmining: Homo sapiens
Simmons, C.R.; Hirschberger, L.L.; Machi, M.S.; Stipanuk, M.H.
Expression, purification, and kinetic characterization of recombinant rat cysteine dioxygenase, a non-heme metalloenzyme necessary for regulation of cellular cysteine levels
Protein Expr. Purif.
47
74-81
2006
BRENDA: Rattus norvegicus
Textmining: Rattus
Ko, K.S.; Torres, C.L.; Fascetti, A.J.; Stipanuk, M.H.; Hirschberger, L.; Rogers, Q.R.
Copper deficiency does not lead to taurine deficiency in rats
J. Nutr.
136
2502-2505
2006
Rattus
Ueki, I.; Stipanuk, M.H.
Enzymes of the taurine biosynthetic pathway are expressed in rat mammary gland
J. Nutr.
137
1887-1894
2007
Rattus
Dominy, J.E.; Hwang, J.; Stipanuk, M.H.
Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells
Am. J. Physiol. Endocrinol. Metab.
293
E62-E69
2007
BRENDA: Rattus norvegicus
Textmining: Mammalia
Oien, D.B.; Moskovitz, J.
Ablation of the mammalian methionine sulfoxide reductase A affects the expression level of cysteine dioxygenase
Biochem. Biophys. Res. Commun.
352
556-559
2007
Mus musculus
Pierce, B.S.; Gardner, J.D.; Bailey, L.J.; Brunold, T.C.; Fox, B.G.
Characterization of the nitrosyl adduct of substrate-bound mouse cysteine dioxygenase by electron paramagnetic resonance: electronic structure of the active site and mechanistic implications
Biochemistry
46
8569-8578
2007
BRENDA: Mus musculus (P60334), Mus musculus
Textmining: Electron
Dominy, J.E.; Simmons, C.R.; Hirschberger, L.L.; Hwang, J.; Coloso, R.M.; Stipanuk, M.H.
Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase
J. Biol. Chem.
282
25189-25198
2007
Mammalia, Homo sapiens, Mus musculus (Q6PDY2), Mus musculus
Dominy, J.E.; Hwang, J.; Guo, S.; Hirschberger, L.L.; Zhang, S.; Stipanuk, M.H.
Synthesis of amino acid cofactor in cysteine dioxygenase is regulated by substrate and represents a novel post-translational regulation of activity
J. Biol. Chem.
283
12188-12201
2008
BRENDA: Rattus norvegicus (P21816)
Textmining: Mammalia
Wuebbeler, J.H.; Bruland, N.; Kretschmer, K.; Steinbuechel, A.
Novel pathway for catabolism of the organic sulfur compound 3,3-dithiodipropionic acid via 3-mercaptopropionic acid and 3-Sulfinopropionic acid to propionyl-coenzyme A by the aerobic bacterium Tetrathiobacter mimigardefordensis strain DPN7
Appl. Environ. Microbiol.
74
4028-4035
2008
Advenella mimigardefordensis, Advenella mimigardefordensis (B3TZE0), bacterium, transposons, insertion sequences
Harris, R.; Turan, N.; Kirk, C.; Ramsden, D.; Waring, R.
Effects of endocrine disruptors on dehydroepiandrosterone sulfotransferase and enzymes involved in PAPS synthesis: genomic and nongenomic pathways
Environ. Health Perspect.
115 Suppl 1
51-54
2007
Homo sapiens, Rodentia
Ueki, I.; Stipanuk, M.H.
3T3-L1 adipocytes and rat adipose tissue have a high capacity for taurine synthesis by the cysteine dioxygenase/cysteinesulfinate decarboxylase and cysteamine dioxygenase pathways
J. Nutr.
139
207-214
2009
BRENDA: Rattus norvegicus
Textmining: Rattus, Mammalia
Stipanuk, M.H.; Ueki, I.; Dominy, J.E.; Simmons, C.R.; Hirschberger, L.L.
Cysteine dioxygenase: a robust system for regulation of cellular cysteine levels
Amino Acids
37
55-63
2009
BRENDA: Rattus norvegicus
Textmining: Mammalia
Honjoh, K.I.; Matsuura, K.; Machida, T.; Nishi, K.; Nakao, M.; Yano, T.; Miyamoto, T.; Iio, M.
Enhancement of menadione stress tolerance in yeast by accumulation of hypotaurine and taurine: co-expression of cDNA clones, from Cyprinus carpio, for cysteine dioxygenase and cysteine sulfinate decarboxylase in Saccharomyces cerevisiae
Amino Acids
38
1173-1183
2009
BRENDA: Cyprinus carpio (Q2PFL1), Cyprinus carpio (Q2PFL2), Cyprinus carpio
Textmining: Saccharomyces cerevisiae, animal
de Visser, S.
Elucidating enzyme mechanism and intrinsic chemical properties of short-lived intermediates in the catalytic cycles of cysteine dioxygenase and taurine/alpha-ketoglutarate dioxygenase
Coord. Chem. Rev.
253
754-768
2009
Homo sapiens (Q16878)
-
Bruland, N.; Wuebbeler, J.H.; Steinbuechel, A.
3-mercaptopropionate dioxygenase, a cysteine dioxygenase homologue, catalyzes the initial step of 3-mercaptopropionate catabolism in the 3,3-thiodipropionic acid-degrading bacterium variovorax paradoxus
J. Biol. Chem.
284
660-672
2009
BRENDA: Variovorax paradoxus
Textmining: bacterium
Kleffmann, T.; Jongkees, S.A.; Fairweather, G.; Wilbanks, S.M.; Jameson, G.N.
Mass-spectrometric characterization of two posttranslational modifications of cysteine dioxygenase
J. Biol. Inorg. Chem.
14
913-921
2009
BRENDA: Rattus norvegicus
Textmining: Electron, Rattus
Stipanuk, M.H.; Ueki, I.
Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur
J. Inherit. Metab. Dis.
34
17-32
2010
Metazoa
Stipanuk, M.H.; Simmons, C.R.; Andrew Karplus, P.; Dominy, J.E.
Thiol dioxygenases: unique families of cupin proteins
Amino Acids
41
91-102
2011
Bacteria, Archaea, eukaryota, Mammalia
Siakkou, E.; Wilbanks, S.M.; Jameson, G.N.
Simplified cysteine dioxygenase activity assay allows simultaneous quantitation of both substrate and product
Anal. Biochem.
405
127-131
2010
Rattus norvegicus
Gardner, J.D.; Pierce, B.S.; Fox, B.G.; Brunold, T.C.
Spectroscopic and computational characterization of substrate-bound mouse cysteine dioxygenase: nature of the ferrous and ferric cysteine adducts and mechanistic implications
Biochemistry
49
6033-6041
2010
Mus musculus
Kasperova, A.; Kunert, J.; Horynova, M.; Weigl, E.; Sebela, M.; Lenobel, R.; Raska, M.
Isolation of recombinant cysteine dioxygenase protein from Trichophyton mentagrophytes
Mycoses
54
e456-462
2011
BRENDA: Trichophyton mentagrophytes (D1MF76), Trichophyton mentagrophytes, Trichophyton mentagrophytes TM-10 (D1MF76)
Textmining: Escherichia coli, Fungi
Crawford, J.A.; Li, W.; Pierce, B.S.
Single turnover of substrate-bound ferric cysteine dioxygenase with superoxide anion: enzymatic reactivation, product formation, and a transient intermediate
Biochemistry
50
10241-10253
2011
BRENDA: Mus musculus
Textmining: Electron
Tchesnokov, E.P.; Wilbanks, S.M.; Jameson, G.N.L.
A strongly bound high-spin iron(II) coordinates cysteine and homocysteine in cysteine dioxygenase
Biochemistry
51
257-264
2012
Rattus norvegicus
Blaesi, E.J.; Gardner, J.D.; Fox, B.G.; Brunold, T.C.
Spectroscopic and computational characterization of the NO adduct of substrate-bound Fe(II) cysteine dioxygenase: insights into the mechanism of O2 activation
Biochemistry
52
6040-6051
2013
BRENDA: Mus musculus
Textmining: Electron
Souness, R.J.; Kleffmann, T.; Tchesnokov, E.P.; Wilbanks, S.M.; Jameson, G.B.; Jameson, G.N.
Mechanistic implications of persulfenate and persulfide binding in the active site of cysteine dioxygenase
Biochemistry
52
7606-7617
2013
Rattus norvegicus (P21816)
Siakkou, E.; Rutledge, M.T.; Wilbanks, S.M.; Jameson, G.N.L.
Correlating crosslink formation with enzymatic activity in cysteine dioxygenase
Biochim. Biophys. Acta
1814
2003-2009
2011
BRENDA: Rattus norvegicus
Textmining: Rattus, Mammalia, Escherichia coli, Chelator
Che, X.; Gao, J.; Liu, Y.; Liu, C.
Metal vs. chalcogen competition in the catalytic mechanism of cysteine dioxygenase
J. Inorg. Biochem.
122
1-7
2013
BRENDA: Rattus norvegicus
Textmining: Electron
Driggers, C.M.; Cooley, R.B.; Sankaran, B.; Hirschberger, L.L.; Stipanuk, M.H.; Karplus, P.A.
Cysteine dioxygenase structures from pH 4 to 9: consistent Cys-persulfenate formation at intermediate pH and a Cys-bound enzyme at higher pH
J. Mol. Biol.
425
3121-3136
2013
Homo sapiens
Kasperova, A.; Kunert, J.; Raska, M.
The possible role of dermatophyte cysteine dioxygenase in keratin degradation
Med. Mycol.
51
449-454
2013
BRENDA: Histoplasma capsulatum, Bacillus sp. (in: Bacteria), Candida albicans, Streptomyces sp., Mammalia, Trichophyton rubrum, Trichophyton mentagrophytes
Textmining: Fungi, Saccharomyces cerevisiae, Arthrodermataceae
Arjune, S.; Schwarz, G.; Belaidi, A.A.
Involvement of the Cys-Tyr cofactor on iron binding in the active site of human cysteine dioxygenase
Amino Acids
47
55-63
2015
BRENDA: Homo sapiens (Q16878), Homo sapiens
Textmining: Felis catus
Wenning, L.; Stoeveken, N.; Wuebbeler, J.H.; Steinbuechel, A.
Substrate and cofactor range differences of two cysteine dioxygenases from Ralstonia eutropha H16
Appl. Environ. Microbiol.
82
910-921
2015
Cupriavidus necator (Q0K029), Cupriavidus necator (Q0KB75), Cupriavidus necator DSM 428 (Q0K029), Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1 (Q0K029), Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1 (Q0KB75)
Davies, C.G.; Fellner, M.; Tchesnokov, E.P.; Wilbanks, S.M.; Jameson, G.N.
The Cys-Tyr cross-link of cysteine dioxygenase changes the optimal pH of the reaction without a structural change
Biochemistry
53
7961-7968
2014
Rattus norvegicus (P21816)
Pietra, F.
On the dynamical behavior of the cysteine dioxygenase-L-cysteine complex in the presence of free dioxygen and L-cysteine
Chem. Biodivers.
14
e1700290
2017
Rattus norvegicus (P21816)
Tchesnokov, E.P.; Faponle, A.S.; Davies, C.G.; Quesne, M.G.; Turner, R.; Fellner, M.; Souness, R.J.; Wilbanks, S.M.; de Visser, S.P.; Jameson, G.N.
An iron-oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase
Chem. Commun. (Camb.)
52
8814-8817
2016
Rattus norvegicus (P21816)
Sallmann, M.; Kumar, S.; Chernev, P.; Nehrkorn, J.; Schnegg, A.; Kumar, D.; Dau, H.; Limberg, C.; de Visser, S.P.
Structure and mechanism leading to formation of the cysteine sulfinate product complex of a biomimetic cysteine dioxygenase model
Chemistry
21
7470-7479
2015
Homo sapiens (Q16878)
Faponle, A.S.; Seebeck, F.P.; de Visser, S.P.
Sulfoxide synthase versus cysteine dioxygenase reactivity in a nonheme iron enzyme
J. Am. Chem. Soc.
139
9259-9270
2017
Rattus norvegicus (P21816)
Driggers, C.M.; Kean, K.M.; Hirschberger, L.L.; Cooley, R.B.; Stipanuk, M.H.; Karplus, P.A.
Structure-based insights into the role of the Cys-Tyr crosslink and inhibitor recognition by mammalian cysteine dioxygenase
J. Mol. Biol.
428
3999-4012
2016
BRENDA: Rattus norvegicus (P21816)
Textmining: Mammalia
Driggers, C.M.; Hartman, S.J.; Karplus, P.A.
Structures of Arg- and Gln-type bacterial cysteine dioxygenase homologs
Protein Sci.
24
154-161
2015
BRENDA: Bacillus subtilis (O32085), Bacillus subtilis, Bacillus subtilis 168 (O32085)
Textmining: Rattus, Cupriavidus necator, Bacteria
Nagasaki, T.; Hongo, Y.; Koito, T.; Nakamura-Kusakabe, I.; Shimamura, S.; Takaki, Y.; Yoshida, T.; Maruyama, T.; Inoue, K.
Cysteine dioxygenase and cysteine sulfinate decarboxylase genes of the deep-sea mussel Bathymodiolus septemdierum possible involvement in hypotaurine synthesis and adaptation to hydrogen sulfide
Amino Acids
47
571-578
2015
Bathymodiolus septemdierum, Bathymodiolus septemdierum (A0A0A8J1X6), Mollusca, Areas
Pierce, B.S.; Subedi, B.P.; Sardar, S.; Crowell, J.K.
The ''Gln-Type'' thiol dioxygenase from Azotobacter vinelandii is a 3-mercaptopropionic acid dioxygenase
Biochemistry
54
7477-7490
2015
Azotobacter vinelandii
Fellner, M.; Aloi, S.; Tchesnokov, E.P.; Wilbanks, S.M.; Jameson, G.N.
Substrate and pH-dependent kinetic profile of 3-mercaptopropionate dioxygenase from Pseudomonas aeruginosa
Biochemistry
55
1362-1371
2016
Pseudomonas aeruginosa (Q9I0N5), Pseudomonas aeruginosa DSM 22644 (Q9I0N5)
Aloi, S.; Davies, C.G.; Karplus, P.A.; Wilbanks, S.M.; Jameson, G.N.L.
Substrate specificity in thiol dioxygenases
Biochemistry
58
2398-2407
2019
Pseudomonas, Rattus norvegicus, Cupriavidus necator, Cupriavidus necator (Q9I0N5)
Bruland, N.; Wuebbeler, J.H.; Steinbuechel, A.
3-Mercaptopropionate dioxygenase, a cysteine dioxygenase homologue, catalyzes the initial step of 3-mercaptopropionate catabolism in the 3,3-thiodipropionic acid-degrading bacterium variovorax paradoxus
J. Biol. Chem.
284
660-672
2009
Variovorax paradoxus, Variovorax paradoxus (B9U5L8), bacterium
Tchesnokov, E.P.; Fellner, M.; Siakkou, E.; Kleffmann, T.; Martin, L.W.; Aloi, S.; Lamont, I.L.; Wilbanks, S.M.; Jameson, G.N.
The cysteine dioxygenase homologue from Pseudomonas aeruginosa is a 3-mercaptopropionate dioxygenase
J. Biol. Chem.
290
24424-24437
2015
Pseudomonas aeruginosa (Q9I0N5), Pseudomonas aeruginosa, Pseudomonas aeruginosa DSM 22644 (Q9I0N5)
White, M.D.; Klecker, M.; Hopkinson, R.J.; Weits, D.A.; Mueller, C.; Naumann, C.; O'Neill, R.; Wickens, J.; Yang, J.; Brooks-Bartlett, J.C.; Garman, E.F.; Grossmann, T.N.; Dissmeyer, N.; Flashman, E.
Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets
Nat. Commun.
8
14690
2017
Arabidopsis thaliana (Q9LXG9), Arabidopsis thaliana (Q9SJI9)
Li, J.; Koto, T.; Davis, I.; Liu, A.
Probing the Cys-Tyr cofactor biogenesis in cysteine dioxygenase by the genetic incorporation of fluorotyrosine
Biochemistry
58
2218-2227
2019
Homo sapiens (Q16878), Homo sapiens
Forbes, D.L.; Meneely, K.M.; Chilton, A.S.; Lamb, A.L.; Ellis, H.R.
The 3-His metal coordination site promotes the coupling of oxygen activation to cysteine oxidation in cysteine dioxygenase
Biochemistry
59
2022-2031
2020
Rattus norvegicus (P21816)
Fischer, A.A.; Lindeman, S.V.; Fiedler, A.T.
A synthetic model of the nonheme iron-superoxo intermediate of cysteine dioxygenase
Chem. Commun. (Camb.)
54
11344-11347
2018
synthetic construct
Song, Z.; Yue, Y.; Feng, S.; Sun, H.; Li, Y.; Xu, F.; Zhang, Q.; Wang, W.
Cysteine dioxygenase catalyzed C-F bond cleavage An in silico approach
Chem. Phys. Lett.
750
137449
2020
Homo sapiens (Q16878)
-
Anandababu, K.; Ramasubramanian, R.; Wadepohl, H.; Comba, P.; Johnee Britto, N.; Jaccob, M.; Mayilmurugan, R.
A structural and functional model for the tris-histidine motif in cysteine dioxygenase
Chemistry
25
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Metazoa, Oncorhynchus mykiss, Paralichthys olivaceus, Chondrichthyes
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Nematoda, Trichostrongylus colubriformis, Ovis aries
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An investigation into possible xenobiotic-endobiotic inter-relationships involving the amino acid analogue drug, S-carboxymethyl-L: -cysteine and plasma amino acids in humans.
Amino Acids
2011
Homo sapiens
Luo, L; Chen, S; Jin, H; Tang, C; Du, J
Endogenous generation of sulfur dioxide in rat tissues.
Biochem Biophys Res Commun
415
61-7
2011
Rattus, Mammalia
Yun, KU; Ryu, CS; Lee, JY; Noh, JR; Lee, CH; Lee, HS; Kang, JS; Park, SK; Kim, BH; Kim, SK
Hepatic metabolism of sulfur amino acids in db/db mice.
Food Chem Toxicol
53
180-6
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Mus sp.
Hennicke, F; Grumbt, M; Lermann, U; Ueberschaar, N; Palige, K; Böttcher, B; Jacobsen, ID; Staib, C; Morschhäuser, J; Monod, M; Hube, B; Hertweck, C; Staib, P
Factors Supporting Cysteine Tolerance and Sulfite Production in Candida albicans.
Eukaryot Cell
12
604-13
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Candida albicans, Homo sapiens, Bacteria, Fungi, Saccharomyces cerevisiae, Mus musculus
Weits, DA; Giuntoli, B; Kosmacz, M; Parlanti, S; Hubberten, HM; Riegler, H; Hoefgen, R; Perata, P; van Dongen, JT; Licausi, F
Plant cysteine oxidases control the oxygen-dependent branch of the N-end-rule pathway.
Nat Commun
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plant, animal
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Amino Acids
47
1273-7
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Rattus
Brandt, U; Galant, G; Meinert-Berning, C; Steinbüchel, A
Functional analysis of active amino acid residues of the mercaptosuccinate dioxygenase of Variovorax paradoxus B4.
Enzyme Microb Technol
120
61-68
2019
Variovorax paradoxus B4, Homo sapiens
Ohta, J; Kwon, YH; Stipanuk, MH
Cysteine dioxygenase and gamma-glutamylcysteine synthetase activities in primary cultured hepatocytes respond to sulfur amino acid supplementation in a reciprocal manner.
Amino Acids
19
705-28
2000
Rattus
Lee, JI; Londono, M; Hirschberger, LL; Stipanuk, MH
Regulation of cysteine dioxygenase and gamma-glutamylcysteine synthetase is associated with hepatic cysteine level.
J Nutr Biochem
15
112-22
2004
Rattus
Perry, TL; Norman, MG; Yong, VW; Whiting, S; Crichton, JU; Hansen, S; Kish, SJ
Hallervorden-Spatz disease: cysteine accumulation and cysteine dioxygenase deficiency in the globus pallidus.
Ann Neurol
18
482-9
1985
Homo sapiens
Qusti, S; Parsons, RB; Abouglila, KD; Waring, RH; Williams, AC; Ramsden, DB
Development of an in vitro model for cysteine dioxygenase expression in the brain.
Cell Biol Toxicol
16
243-55
2000
Homo sapiens, Metazoa
Aluri, S; de Visser, SP
The mechanism of cysteine oxygenation by cysteine dioxygenase enzymes.
J Am Chem Soc
129
14846-7
2007
Electron
Joseph, CA; Maroney, MJ
Cysteine dioxygenase: structure and mechanism.
Chem Commun (Camb)
3338-49
2007
Homo sapiens, Mus musculus, Rattus
Stipanuk, MH; Dominy, JE; Ueki, I; Hirschberger, LL
Measurement of Cysteine Dioxygenase Activity and Protein Abundance.
Curr Protoc toxicol
38
6.15.1-6.15.25
2008
Chelator
Kumar, D; Thiel, W; de Visser, SP
Theoretical study on the mechanism of the oxygen activation process in cysteine dioxygenase enzymes.
J Am Chem Soc
133
3869-82
2011
Homo sapiens
Ueki, I; Roman, HB; Valli, A; Fieselmann, K; Lam, J; Peters, R; Hirschberger, LL; Stipanuk, MH
Knockout of the cysteine dioxygenase gene results in severe impairment in taurine synthesis and increased catabolism of cysteine to hydrogen sulfide.
Am J Physiol Endocrinol Metab
2011
Mus sp., Electron
Cho, J; Woo, J; Nam, W
A chromium(III)-superoxo complex in oxygen atom transfer reactions as a chemical model of cysteine dioxygenase.
J Am Chem Soc
134
11112-5
2012
Avena sp.
Hagiwara, A; Ishizaki, S; Takehana, K; Fujitani, S; Sonaka, I; Satsu, H; Shimizu, M
Branched-chain amino acids inhibit the TGF-beta-induced down-regulation of taurine biosynthetic enzyme cysteine dioxygenase in HepG2 cells.
Amino Acids
46
1275-83
2014
Rattus, Homo sapiens
Blaesi, EJ; Fox, BG; Brunold, TC
Spectroscopic and computational investigation of iron(III) cysteine dioxygenase: implications for the nature of the putative superoxo-Fe(III) intermediate.
Biochemistry
53
5759-70
2014
Electron
Deng, P; Chen, Y; Ji, N; Lin, Y; Yuan, Q; Ye, L; Chen, Q
Cysteine dioxygenase type 1 promotes adipogenesis via interaction with peroxisome proliferator-activated receptor gamma.
Biochem Biophys Res Commun
458
123-7
2015
Mus musculus
Blaesi, EJ; Fox, BG; Brunold, TC
Spectroscopic and Computational Investigation of the H155A Variant of Cysteine Dioxygenase: Geometric and Electronic Consequences of a Third-Sphere Amino Acid Substitution.
Biochemistry
54
2874-84
2015
Electron
Kwon, J; Park, M; Kim, JH; Lee, HW; Kang, MC; Park, JH
Epigenetic regulation of the novel tumor suppressor cysteine dioxygenase 1 in esophageal squamous cell carcinoma.
Tumour Biol
36
7449-56
2015
Homo sapiens
Minatani, N; Waraya, M; Yamashita, K; Kikuchi, M; Ushiku, H; Kojo, K; Ema, A; Nishimiya, H; Kosaka, Y; Katoh, H; Sengoku, N; Tanino, H; Sidransky, D; Watanabe, M
Prognostic Significance of Promoter DNA Hypermethylation of cysteine dioxygenase 1 (CDO1) Gene in Primary Breast Cancer.
PLoS One
11
e0144862
2016
Homo sapiens, Indicator
Igarashi, K; Yamashita, K; Katoh, H; Kojima, K; Ooizumi, Y; Nishizawa, N; Nishiyama, R; Kawamata, H; Tajima, H; Kaizu, T; Kumamoto, Y; Watanabe, M
Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease.
PLoS One
12
e0188178
2017
Homo sapiens
Kojima, K; Nakamura, T; Ohbu, M; Katoh, H; Ooizumi, Y; Igarashi, K; Ishii, S; Tanaka, T; Yokoi, K; Nishizawa, N; Yokota, K; Kosaka, Y; Sato, T; Watanabe, M; Yamashita, K
Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer.
PLoS One
13
e0194785
2018
Homo sapiens
Harada, H; Hosoda, K; Moriya, H; Mieno, H; Ema, A; Ushiku, H; Washio, M; Nishizawa, N; Ishii, S; Yokota, K; Tanaka, Y; Kaida, T; Soeno, T; Kosaka, Y; Watanabe, M; Yamashita, K
Cancer-specific promoter DNA methylation of Cysteine dioxygenase type 1 (CDO1) gene as an important prognostic biomarker of gastric cancer.
PLoS One
14
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2019
Homo sapiens
Ohkuma, S; Tomono, S; Tanaka, Y; Kuriyama, K; Mukainaka, T
Development of taurine biosynthesizing system in cerebral cortical neurons in primary culture.
Int J Dev Neurosci
4
383-95
1986
Electron, Mus sp., Oryctolagus cuniculus
Bella, DL; Hahn, C; Stipanuk, MH
Effects of nonsulfur and sulfur amino acids on the regulation of hepatic enzymes of cysteine metabolism.
Am J Physiol
277
E144-53
1999
Rattus
Schuller-Levis, GB; Park, E
Taurine: new implications for an old amino acid.
FEMS Microbiol Lett
226
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2003
Rattus
Jiang, H; Stabler, SP; Allen, RH; Abman, SH; Maclean, KN
Altered hepatic sulfur metabolism in cystathionine ?-synthase-deficient homocystinuria: regulatory role of taurine on competing cysteine oxidation pathways.
FASEB J
2014
Mus musculus, Metazoa
Chen, SS; Chen, JF; Johnson, PF; Muppala, V; Lee, YH
C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue.
Mol Cell Biol
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7292-9
2000
Mus musculus, Mus sp.
Wang, W; Wang, S; Pan, L
Identification of key differentially expressed mRNAs and microRNAs in non-small cell lung cancer using bioinformatics analysis.
Exp Ther Med
20
3720-3732
2020
Homo sapiens
Stipanuk, MH; Dominy, JE; Lee, JI; Coloso, RM
Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism.
J Nutr
136
1652S-1659S
2006
Areas, Rattus
Prabhu, A; Sarcar, B; Kahali, S; Yuan, Z; Johnson, JJ; Adam, KP; Kensicki, E; Chinnaiyan, P
Cysteine catabolism: a novel metabolic pathway contributing to glioblastoma growth.
Cancer Res
74
787-96
2014
Mus musculus
Hromada, SE; Hilbrands, AM; Wolf, EM; Ross, JL; Hegg, TR; Roth, AG; Hollowell, MT; Anderson, CE; Benson, DE
Protein oxidation involved in Cys-Tyr post-translational modification.
J Inorg Biochem
176
168-174
2017
Electron
Morrow, WP; Sardar, S; Thapa, P; Hossain, MS; Foss, FW; Pierce, BS
Thiol dioxygenase turnover yields benzothiazole products from 2-mercaptoaniline and O2-dependent oxidation of primary alcohols.
Arch Biochem Biophys
631
66-74
2017
Mus musculus
Tanaka, Y; Kosaka, Y; Waraya, M; Yokota, K; Harada, H; Kaida, T; Kikuchi, M; Minatani, N; Nishimiya, H; Katoh, H; Sengoku, N; Watanabe, M; Yamashita, K
Differential Prognostic Relevance of Promoter DNA Methylation of CDO1 and HOPX in Primary Breast Cancer.
Anticancer Res
39
2289-2298
2019
Homo sapiens
Jung, YS; Kim, SJ; Kwon, DY; Ahn, CW; Kim, YS; Choi, DW; Kim, YC
Alleviation of alcoholic liver injury by betaine involves an enhancement of antioxidant defense via regulation of sulfur amino acid metabolism.
Food Chem Toxicol
62C
292-298
2013
Rattus
Pean, A; Steventon, GB; Waring, RH; Foster, H; Sturman, S; Williams, AC
Pathways of cysteine metabolism in MND/ALS.
J Neurol Sci
124 Suppl
59-61
1994
Homo sapiens
Takasaki, M; Satsu, H; Shimizu, M
Physiological significance of the taurine transporter and taurine biosynthetic enzymes in 3T3-L1 adipocytes.
Biofactors
21
419-21
2004
Mus musculus
Hamad, EA; Zhu, W; Chan, TO; Myers, V; Gao, E; Li, X; Zhang, J; Song, J; Zhang, XQ; Cheung, JY; Koch, W; Feldman, AM
Cardioprotection of controlled and cardiac-specific over-expression of A(2A)-adenosine receptor in the pressure overload.
PLoS One
7
e39919
2012
Mus sp.
Yang, Y; Fan, YC; Gao, S; Dou, CY; Zhang, JJ; Sun, FK; Wang, K
Methylated cysteine dioxygenase-1 gene promoter in the serum is a potential biomarker for hepatitis B virus-related hepatocellular carcinoma.
Tohoku J Exp Med
232
187-94
2014
Hepatitis B virus, Homo sapiens
Fellner, M; Doughty, LM; Jameson, GN; Wilbanks, SM
A chromogenic assay of substrate depletion by thiol dioxygenases.
Anal Biochem
459
56-60
2014
Rattus norvegicus
Njeri, CW; Ellis, HR
Shifting redox states of the iron center partitions CDO between crosslink formation or cysteine oxidation.
Arch Biochem Biophys
558
61-9
2014
Chelator, Electron
Yamashita, K; Waraya, M; Kim, MS; Sidransky, D; Katada, N; Sato, T; Nakamura, T; Watanabe, M
Detection of methylated CDO1 in plasma of colorectal cancer; a PCR study.
PLoS One
9
e113546
2014
Homo sapiens
Deshpande, AA; Bhatia, M; Laxman, S; Bachhawat, AK
Thiol trapping and metabolic redistribution of sulfur metabolites enable cells to overcome cysteine overload.
Microb Cell
4
112-126
2017
Saccharomyces cerevisiae, Mammalia
Yokoi, K; Harada, H; Yokota, K; Ishii, S; Tanaka, T; Nishizawa, N; Shimazu, M; Kojo, K; Miura, H; Yamanashi, T; Sato, T; Nakamura, T; Watanabe, M; Yamashita, K
Epigenetic Status of CDO1 Gene May Reflect Chemosensitivity in Colon Cancer with Postoperative Adjuvant Chemotherapy.
Ann Surg Oncol
26
406-414
2019
Homo sapiens
Nakamoto, S; Kumamoto, Y; Igarashi, K; Fujiyama, Y; Nishizawa, N; Ei, S; Tajima, H; Kaizu, T; Watanabe, M; Yamashita, K
Methylated promoter DNA of CDO1 gene and preoperative serum CA19-9 are prognostic biomarkers in primary extrahepatic cholangiocarcinoma.
PLoS One
13
e0205864
2018
Homo sapiens, Indicator
Harada, H; Soeno, T; Nishizawa, N; Washio, M; Sakuraya, M; Ushiku, H; Niihara, M; Hosoda, K; Kumamoto, Y; Naitoh, T; Sangai, T; Hiki, N; Yamashita, K
Prospective study to validate the clinical utility of DNA diagnosis of peritoneal fluid cytology test in gastric cancer.
Cancer Sci
112
1644-1654
2021
Homo sapiens
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