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Information on EC 1.11.1.9 - glutathione peroxidase and Organism(s) Homo sapiens and UniProt Accession Q96SL4

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EC Tree
     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.9 glutathione peroxidase
IUBMB Comments
A protein containing a selenocysteine residue. Steroid and lipid hydroperoxides, but not the product of reaction of EC 1.13.11.12 lipoxygenase on phospholipids, can act as acceptor, but more slowly than H2O2 (cf. EC 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase).
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This record set is specific for:
Homo sapiens
UNIPROT: Q96SL4
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
glutathione peroxidase, gpx, gsh-px, ebselen, gshpx, gpx-1, gsh peroxidase, glutathione peroxidase 1, plasma glutathione peroxidase, selenium-dependent glutathione peroxidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
GPx-7
the isozyme has only low glutathione peoxidase activity
2-SeCD
-
GPX mimic
6P229
-
-
-
-
ARMEP24
-
-
-
-
AtGPX1
-
-
-
-
Cellular glutathione peroxidase
-
-
-
-
cGPx
-
-
Cuticular glycoprotein GP29
-
-
-
-
DI29
-
-
-
-
ebselen
-
GPX mimic
EGLP
-
-
-
-
Epididymis-specific glutathione peroxidase-like protein
-
-
-
-
Extracellular glutathione peroxidase
-
-
-
-
Gastrointestinal glutathione peroxidase
-
-
-
-
glutathione peroxidase 1
-
-
glutathione peroxidase 3
glutathione peroxidase 4
-
-
glutathione peroxidase-1
-
-
glutathione peroxidase-3
-
GP30
-
-
-
-
GPRP
-
-
-
-
Gpx-1
GPx-2
previously known as GSHPx-GI
GPx-3
GPx-4
GPx-5
previously known as epididymal GPx or eGPx
GPx-6
previously named olfactory-metabolizing protein or OMP
GPX5
-
-
GSH peroxidase
-
-
-
-
GSHPx-GI
-
-
-
-
Major androgen-regulated protein
-
-
-
-
Major surface antigen GP29
-
-
-
-
Nt-SubC08
-
-
-
-
Odorant-metabolizing protein RY2D1
-
-
-
-
peroxidase, glutathione
-
-
-
-
phospholipid hydroperoxide glutathione peroxidase
-
-
phospholipid hydroperoxide glutathione peroxidase, nuclear form
-
n-PHGPx
reduced glutathione peroxidase
-
-
-
-
Salt-associated protein
-
-
-
-
Se-hGSTZ1-1
-
-
Se-scFv-B3
-
GPX mimic
selenium containing glutathione transferase zeta1-1
-
-
selenium-glutathione peroxidase
-
-
-
-
selenosubtilisin
-
artificial enzyme that imitates the active site of antioxidant selenoenzyme glutathione peroxidase, the imprinted selenium-containing protein exhibits remarkable GPx activity
snGPx
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
glutathione:hydrogen-peroxide oxidoreductase
A protein containing a selenocysteine residue. Steroid and lipid hydroperoxides, but not the product of reaction of EC 1.13.11.12 lipoxygenase on phospholipids, can act as acceptor, but more slowly than H2O2 (cf. EC 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase).
CAS REGISTRY NUMBER
COMMENTARY hide
9013-66-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
H2O2 + GSH
H2O + GSSG
show the reaction diagram
-
-
-
?
H2O2 + thioredoxin
H2O + ?
show the reaction diagram
-
-
-
?
1-palmitoyl-2-(13-hydroperoxy-cis-9, trans-11-octadecadienoyl)-L-3-phosphatidylcholine + 2 GSH
1-palmitoyl-2-(13-hydroxy-cis-9, trans-11-octadecadienoyl)-L-3-phosphatidylcholine + GSSG + H2O
show the reaction diagram
-
-
-
?
2 glutathione + H2O2
glutathione disulfide + 2 H2O
show the reaction diagram
5-hydroperoxyeicosatetraenoic acid + 2 GSH
5-hydroxyeicosatetraenoic acid + GSSG + H2O
show the reaction diagram
-
-
-
-
?
cumene hydroperoxide + GSH
?
show the reaction diagram
-
-
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
show the reaction diagram
H2O2 + GSH
H2O + GSSG
show the reaction diagram
H2O2 + ROOH
H2O + ROH
show the reaction diagram
-
-
-
-
?
H2O2 + thioredoxin
H2O + ?
show the reaction diagram
-
-
-
?
L-alpha-phosphatidylcholine hydroperoxide + GSH
?
show the reaction diagram
-
-
-
-
r
linolenic acid hydroperoxide + GSH
?
show the reaction diagram
-
-
-
-
?
lipid peroxide + GSH
? + GSSG
show the reaction diagram
-
-
-
-
?
protamine + H2O2
?
show the reaction diagram
-
snGPx acts as a protamine cysteine thiol peroxidase
-
-
?
tert-butyl hydroperoxide + 2 GSH
tert-butyl alcohol + GSSG + H2O
show the reaction diagram
-
-
-
-
?
tert-butyl hydroperoxide + GSH
tert-butyl alcohol + GSSG + H2O
show the reaction diagram
-
-
-
-
?
tert-butylhydroperoxide + 3-carboxy-4-nitrobenzenethiol
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
5-hydroperoxyeicosatetraenoic acid + 2 GSH
5-hydroxyeicosatetraenoic acid + GSSG + H2O
show the reaction diagram
-
-
-
-
?
cumene hydroperoxide + GSH
?
show the reaction diagram
-
-
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
show the reaction diagram
H2O2 + GSH
H2O + GSSG
show the reaction diagram
-
-
-
-
?
linolenic acid hydroperoxide + GSH
?
show the reaction diagram
-
-
-
-
?
tert-butyl hydroperoxide + 2 GSH
tert-butyl alcohol + GSSG + H2O
show the reaction diagram
-
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
selenium
activity depends on selenium
selenium
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
CN-
-
no inhibition if simultaneously incubated with 2-mercaptoethanol, glutathione or dithiothreitol
docosahexaenoic acid
-
0.1 mM reduces the level of protein expression of GPx-4 by at least 50%
Mercaptosuccinate
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
etoposide
-
activates p53, wich induces the expression of glutathione peroxidase
genistein
-
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.006
cumene hydroperoxide
-
-
0.022 - 1.33
glutathione
0.2 - 11.1
GSH
0.02 - 19.08
H2O2
0.026
L-alpha-phosphatidylcholine hydroperoxide
-
-
-
0.024
tert-butylhydroperoxide
-
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.8 - 683
glutathione
14.48 - 408.3
GSH
4.7 - 727.8
H2O2
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
216.7
glutathione
231.7
H2O2
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.52
wild-type, pH 7.4, 37°C
11.9
-
U2-OS treated with etoposide
2.24
-
-
25
mutant with all Cys residues changed to Ser, substrate H2O2, pH 7.4, 37°C
5
-
Saos-2
5.28
mutant C2S/C78S/C115S/C156S/C202S, pH 7.4, 37°C
5.5
-
Saos-2 treated with etoposide
6.7
-
U2-OS
8.5
mutant with all Cys residues changed to Ser, substrate 1-palmitoyl-2-(13-hydroperoxy-cis-9, trans-11-octadecadienoyl)-L-3-phosphatidylcholine, pH 7.4, 37°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8
-
assay at
8.9
mutant with all Cys residues changed to Ser
9
mutant C2S/C78S/C115S/C156S/C202S
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
26% of maximum activity, mutant C2S/C78S/C115S/C156S/C202S
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
-
assay at
37
mutant C2S/C78S/C115S/C156S/C202S
45
mutant with all Cys residues changed to Ser
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50
75% of maximum activity, mutant C2S/C78S/C115S/C156S/C202S
55
almost completely inactive
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GPx1 is highly expressed in adrenal glands
Manually annotated by BRENDA team
GPx-3 is detected at very low levels under basal conditions
Manually annotated by BRENDA team
-
human endothelial cell line Ea.hy926
Manually annotated by BRENDA team
GPx-3 is detected at very low levels under basal conditions
Manually annotated by BRENDA team
-
human primary pulmonary artery endothelial cells
Manually annotated by BRENDA team
-
a non-transformed lung epithelial cell line
Manually annotated by BRENDA team
GPx-3 is detected at very low levels under basal conditions
Manually annotated by BRENDA team
-
GPX2
Manually annotated by BRENDA team
-
upregulated Gpx-1 activity is associated with neuroprotection in vitro
Manually annotated by BRENDA team
GPx3 is widely inactivated in prostate cancer cells
Manually annotated by BRENDA team
-
GPX2
Manually annotated by BRENDA team
GPx3 is exclusively expressed in thyrocytes
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
methylmercury neurotoxicity is associated with inhibition of glutathione peroxidase
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GPX7_HUMAN
187
0
20996
Swiss-Prot
Secretory Pathway (Reliability: 1)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20000
-
SDS-PAGE
24000
-
SDS-PAGE, truncated and active form of snGPx produced by cleavage at the N-terminal end
34000
-
SDS-PAGE, inactive full-length enzyme
75000 - 85500
-
gel filtration
90000 - 100000
-
gel filtration
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
GPX5
homotetramer
monomer
tetramer
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
molecular modeling of mutant with all Cys residues changed to Ser
molecular modeling of the structure of seleno-hGPx2
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C2S/C78S/C115S/C156S/C202S
about 10fold increase in activity compared to wild-type. Mutant displays a typical ping-pong mechanism
S14A
-
mutant shows reduced selenium content and strongly reduced glutathione peroxidase activity
S15A
-
mutant shows reduced selenium content and reduced glutathione peroxidase activity
additional information
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5
-
extremely unstable below
396616
7.4 - 8.9
-
743791
9.8
93% loss of activity
743791
additional information
-
unstable at low pH
396643
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity
-
stabilization by 2-mercaptoethanol
-
stabilization by glutathione or dithiothreitol
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, more than 4 months
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
nickel-agarose column chromatography
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
-
expressed in Mus musculus
-
expressed in PC-3 cells, LNCaP cells, and DU-145 cells
expression constructs encoding full-length (1-201) and C-terminal deletion (1-100) versions of human GPX1 (Sec47Cys) for overexpression in HEK-293 cells
-
expression in Escherichia coli
expression in MCF-7c1 cells
-
human enzyme expressed in transgenic mice. Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function
-
overexpression of Gpx4 in mice
-
the human GPx-1 gen is expressed in transgenic mice
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
GPx-3 is induced by MG132 in HUVEC cells with an exponential increase in GPx-3 mRNA up to 120fold of control levels within 48 h. GPx-3 is still upregulated by a factor of 3-4 even after 72 and 96 h of proteasome inhibition. HAEC cells upregulate GPx-3 by more than 40fold in response to MG132. Proteasome inhibition clearly induces GPx-3 in HAoSMCs by a factor of 18
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
-
activity is important in predicting tissue redox state
medicine
synthesis
construction of recombinant proteins carrying both the activity of human glutathione peroxidase and Alvinella pompejana superoxide dismutase and expression in a single protein production system. The best construct displays excellent antioxidant capacity and synergistic effects of hte two activities
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Charmagnol, F.; Sinet, P.M.; Jerome, H.
Selenium-dependent and non-selenium-dependent glutathione peroxidases in human tissue extracts
Biochim. Biophys. Acta
759
49-57
1983
Homo sapiens
Manually annotated by BRENDA team
Awasthi, Y.C.; Dao, D.D.; Lal, A.K.; Srivastava, S.K.
Purification and properties of glutathione peroxidase from human placenta
Biochem. J.
177
471-476
1979
Homo sapiens
Manually annotated by BRENDA team
Tan, M.; Li, S.; Swaroop, M.; Guan, K.; Oberley, L.W.; Sun, Y.
Transcriptional activation of the human glutathione peroxidase promoter by p53
J. Biol. Chem.
274
12061-12066
1999
Homo sapiens
Manually annotated by BRENDA team
Chu, F.F.; Doroshow, J.H.; Esworthy, R.S.
Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI
J. Biol. Chem.
268
2571-2576
1993
Homo sapiens
Manually annotated by BRENDA team
Rey, C.; Vericel, E.; Nemoz, G.; Chen, W.; Chapuy, P.; Lagarde, M.
Purification and characterization of glutathione peroxidase from human blood platelets. Age-related changes in the enzyme
Biochim. Biophys. Acta
1226
219-224
1994
Homo sapiens
Manually annotated by BRENDA team
Januel, C.; Fay, L.B.; Ruggiero, D.; Lagarde, M.; Vericel, E.
Covalent coupling of reduced glutathione with ribose: loss of cosubstrate ability to glutathione peroxidase
Biochim. Biophys. Acta
1620
125-132
2003
Homo sapiens
Manually annotated by BRENDA team
Suzuki, K.; Koike, H.; Matsui, H.; Ono, Y.; Hasumi, M.; Nakazato, H.; Okugi, H.; Sekine, Y.; Oki, K.; Ito, K.; Yamamoto, T.; Fukabori, Y.; Kurokawa, K.; Yamanaka, H.
Genistein, a soy isoflavone, induces glutathione peroxidase in the human prostate cancer cell lines LNCaP and PC-3
Int. J. Cancer
99
846-852
2002
Homo sapiens
Manually annotated by BRENDA team
Ran, Q.; Liang, H.; Gu, M.; Qi, W.; Walter, C.A.; Roberts, L.J.2nd.; Herman, B.; Richardson, A.; Van Remmen, H.
Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis
J. Biol. Chem.
279
55137-55146
2004
Homo sapiens
Manually annotated by BRENDA team
Stephensen, C.B.; Marquis, G.S.; Douglas, S.D.; Kruzich, L.A.; Wilson, C.M.
Glutathione, glutathione peroxidase, and selenium status in HIV-positive and HIV-negative adolescents and young adults
Am. J. Clin. Nutr.
85
173-181
2007
Homo sapiens
Manually annotated by BRENDA team
Kaynar, H.; Meral, M.; Turhan, H.; Keles, M.; Celik, G.; Akcay, F.
Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu-Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer
Cancer Lett.
227
133-139
2005
Homo sapiens
Manually annotated by BRENDA team
Zhang, Y.; Handy, D.E.; Loscalzo, J.
Adenosine-dependent induction of glutathione peroxidase 1 in human primary endothelial cells and protection against oxidative stress
Circ. Res.
96
831-837
2005
Homo sapiens
Manually annotated by BRENDA team
McLean, C.W.; Mirochnitchenko, O.; Claus, C.P.; Noble-Haeusslein, L.J.; Ferriero, D.M.
Overexpression of glutathione peroxidase protects immature murine neurons from oxidative stress
Dev. Neurosci.
27
169-175
2005
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Mysore, T.B.; Shinkel, T.A.; Collins, J.; Salvaris, E.J.; Fisicaro, N.; Murray-Segal, L.J.; Johnson, L.E.; Lepore, D.A.; Walters, S.N.; Stokes, R.; Chandra, A.P.; OConnell, P.J.; dApice, A.J.; Cowan, P.J.
Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function
Diabetes
54
2109-2116
2005
Homo sapiens
Manually annotated by BRENDA team
Steinbrenner, H.; Bilgic, E.; Alili, L.; Sies, H.; Brenneisen, P.
Selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity
Free Radic. Res.
40
936-943
2006
Homo sapiens
Manually annotated by BRENDA team
Romanowska, M.; Kikawa, K.D.; Fields, J.R.; Maciag, A.; North, S.L.; Shiao, Y.H.; Kasprzak, K.S.; Anderson, L.M.
Effects of selenium supplementation on expression of glutathione peroxidase isoforms in cultured human lung adenocarcinoma cell lines
Lung Cancer
55
35-42
2007
Homo sapiens
Manually annotated by BRENDA team
Drevet, J.R.
The antioxidant glutathione peroxidase family and spermatozoa: a complex story
Mol. Cell. Endocrinol.
250
70-79
2006
Bos taurus, Canis lupus familiaris, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Yang, M.S.; Chan, H.W.; Yu, L.C.
Glutathione peroxidase and glutathione reductase activities are partially responsible for determining the susceptibility of cells to oxidative stress
Toxicology
226
126-130
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Toppo, S.; Vanin, S.; Bosello, V.; Tosatto, S.C.
Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily
Antioxid. Redox Signal.
10
1501-1514
2008
Homo sapiens (O75715), Homo sapiens (P07203), Homo sapiens (P18283), Homo sapiens (P22352), Homo sapiens (P59796), Homo sapiens (Q6PI42), Homo sapiens (Q8TED1), Homo sapiens (Q96SL4)
Manually annotated by BRENDA team
Bertelsmann, H.; Kuehbacher, M.; Weseloh, G.; Kyriakopoulos, A.; Behne, D.
Sperm nuclei glutathione peroxidases and their occurrence in animal species with cysteine-containing protamines
Biochim. Biophys. Acta
1770
1459-1467
2007
Equus caballus, Homo sapiens, no activity in Gallus gallus, Rattus norvegicus, no activity in Onchorhynchus mykiss
Manually annotated by BRENDA team
Schmutzler, C.; Mentrup, B.; Schomburg, L.; Hoang-Vu, C.; Herzog, V.; Koehrle, J.
Selenoproteins of the thyroid gland: expression, localization and possible function of glutathione peroxidase 3
Biol. Chem.
388
1053-1059
2007
Homo sapiens (P07203), Homo sapiens (P22352), Homo sapiens (Q6PI42)
Manually annotated by BRENDA team
Liu, L.; Mao, S.Z.; Liu, X.M.; Huang, X.; Xu, J.Y.; Liu, J.Q.; Luo, G.M.; Shen, J.C.
Functional mimicry of the active site of glutathione peroxidase by glutathione imprinted selenium-containing protein
Biomacromolecules
9
363-368
2008
Homo sapiens
Manually annotated by BRENDA team
Yu, Y.P.; Yu, G.; Tseng, G.; Cieply, K.; Nelson, J.; Defrances, M.; Zarnegar, R.; Michalopoulos, G.; Luo, J.H.
Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis
Cancer Res.
67
8043-8050
2007
Homo sapiens (P22352)
Manually annotated by BRENDA team
Robertson, R.P.; Harmon, J.S.
Pancreatic islet beta-cell and oxidative stress: the importance of glutathione peroxidase
FEBS Lett.
581
3743-3748
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Zheng, K.; Board, P.G.; Fei, X.; Sun, Y.; Lv, S.; Yan, G.; Liu, J.; Shen, J.; Luo, G.
A novel selenium-containing glutathione transferase zeta1-1, the activity of which surpasses the level of some native glutathione peroxidases
Int. J. Biochem. Cell Biol.
40
2090-2097
2008
Homo sapiens
Manually annotated by BRENDA team
Barschak, A.G.; Sitta, A.; Deon, M.; Barden, A.T.; Schmitt, G.O.; Dutra-Filho, C.S.; Wajner, M.; Vargas, C.R.
Erythrocyte glutathione peroxidase activity and plasma selenium concentration are reduced in maple syrup urine disease patients during treatment
Int. J. Dev. Neurosci.
25
335-338
2007
Homo sapiens
Manually annotated by BRENDA team
Prasad, C.V.; Kodliwadmath, M.V.; Kodliwadmath, G.B.
Erythrocyte glutathione peroxidase, glutathione reductase activities and blood glutathione content in leprosy
J. Infect.
56
469-473
2008
Homo sapiens
Manually annotated by BRENDA team
Huo, R.; Wei, J.; Xu, J.; Lv, S.; Zheng, Q.; Yan, F.; Su, J.; Fan, J.; Li, J.; Duan, Y.; Yu, Y.; Jin, F.; Sun, W.; Shi, Y.; Cong, D.; Li, W.; Yan, G.; Luo, G.
Human catalytic antibody Se-scFv-B3 with high glutathione peroxidase activity
J. Mol. Recognit.
21
324-329
2008
Homo sapiens
Manually annotated by BRENDA team
Ding, W.Q.; Lind, S.E.
Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity
Mol. Cancer Ther.
6
1467-1474
2007
Homo sapiens
Manually annotated by BRENDA team
Jacobson, G.A.; Yee, K.C.; Ng, C.H.
Elevated plasma glutathione peroxidase concentration in acute severe asthma: comparison with plasma glutathione peroxidase activity, selenium and malondialdehyde
Scand. J. Clin. Lab. Invest.
67
423-430
2007
Homo sapiens
Manually annotated by BRENDA team
Tsuru-Aoyagi, K.; Potts, M.B.; Trivedi, A.; Pfankuch, T.; Raber, J.; Wendland, M.; Claus, C.P.; Koh, S.E.; Ferriero, D.; Noble-Haeusslein, L.J.
Glutathione peroxidase activity modulates recovery in the injured immature brain
Ann. Neurol.
65
540-549
2009
Homo sapiens
Manually annotated by BRENDA team
Ha, E.J.; Smith, A.M.
Selenium-dependent glutathione peroxidase activity is increased in healthy post-menopausal women
Biol. Trace Elem. Res.
131
90-95
2009
Homo sapiens
Manually annotated by BRENDA team
Bae, Y.; Cai, G.; Kim, S.; Zo, Y.; Kong, Y.
Modular evolution of glutathione peroxidase genes in association with different biochemical properties of their encoded proteins in invertebrate animals
BMC Evol. Biol.
9
72
2009
Homo sapiens (P07203), Homo sapiens (P22352), Brugia pahangi (P67878), Schistosoma mansoni (Q00277), Paragonimus westermani (Q1PBM0), Paragonimus westermani (Q1PBM1), Schistosoma japonicum (Q86EQ5)
Manually annotated by BRENDA team
Espinoza, S.E.; Guo, H.; Fedarko, N.; DeZern, A.; Fried, L.P.; Xue, Q.L.; Leng, S.; Beamer, B.; Walston, J.D.
Glutathione peroxidase enzyme activity in aging
J. Gerontol. A Biol. Sci. Med. Sci.
63
505-509
2008
Homo sapiens
Manually annotated by BRENDA team
He, T.; Joyner, M.J.; Katusic, Z.S.
Aging decreases expression and activity of glutathione peroxidase-1 in human endothelial progenitor cells
Microvasc. Res.
78
447-452
2009
Homo sapiens
Manually annotated by BRENDA team
Chung, S.S.; Kim, M.; Youn, B.S.; Lee, N.S.; Park, J.W.; Lee, I.K.; Lee, Y.S.; Kim, J.B.; Cho, Y.M.; Lee, H.K.; Park, K.S.
Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells
Mol. Cell. Biol.
29
20-30
2009
Homo sapiens
Manually annotated by BRENDA team
Takata, Y.; Morris, J.S.; King, I.B.; Kristal, A.R.; Lin, D.W.; Peters, U.
Correlation between selenium concentrations and glutathione peroxidase activity in serum and human prostate tissue
Prostate
69
1635-1642
2009
Homo sapiens
Manually annotated by BRENDA team
Yang, W.H.; Park, S.Y.; Ji, S.; Kang, J.G.; Kim, J.-E.; Song, H.; Mook-Jung, I.; Choe, K.-M.; Cho, J.W.
O-GlcNAcylation regulates hyperglycemia-induced GPX1 activation
Biochem. Biophys. Res. Commun.
391
756-761
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Westphal, K.; Stangl, V.; Faehling, M.; Dreger, H.; Weller, A.; Baumann, G.; Stangl, K.; Meiners, S.
Human-specific induction of glutathione peroxidase-3 by proteasome inhibition in cardiovascular cells
Free Radic. Biol. Med.
47
1652-1660
2009
no activity in Bos taurus, Homo sapiens (P22352), Homo sapiens
Manually annotated by BRENDA team
Franco, J.L.; Posser, T.; Dunkley, P.R.; Dickson, P.W.; Mattos, J.J.; Martins, R.; Bainy, A.C.; Marques, M.R.; Dafre, A.L.; Farina, M.
Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase
Free Radic. Biol. Med.
47
449-457
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Guan, T.; Song, J.; Wang, Y.; Guo, L.; Yuan, L.; Zhao, Y.; Gao, Y.; Lin, L.; Wang, Y.; Wei, J.
Expression and characterization of recombinant bifunctional enzymes with glutathione peroxidase and superoxide dismutase activities
Free Radic. Biol. Med.
110
188-195
2017
Homo sapiens (P07203), Homo sapiens
Manually annotated by BRENDA team
Guo, X.; Song, J.; Guan, T.; Wang, S.; Wang, Y.; Meng, Y.; Guo, J.; Li, T.; Ma, C.; Wei, J.
Characterization of recombinant human gastrointestinal glutathione peroxidase mutant produced in Escherichia coli
Free Radic. Res.
49
228-235
2015
Homo sapiens (P18283), Homo sapiens
Manually annotated by BRENDA team
Guo, X.; Yu, Y.; Liu, X.; Zhang, Y.; Guan, T.; Xie, G.; Wei, J.
Heterologous expression and characterization of human cellular glutathione peroxidase mutants
IUBMB Life
66
212-219
2014
Homo sapiens (P07203)
-
Manually annotated by BRENDA team
Song, J.; Yu, Y.; Xing, R.; Guo, X.; Liu, D.; Wei, J.; Song, H.
Unglycosylated recombinant human glutathione peroxidase 3 mutant from Escherichia coli is active as a monomer
Sci. Rep.
4
6698
2014
Homo sapiens (P22352), Homo sapiens
Manually annotated by BRENDA team
Lee, W.; Chen, Y.; Chu, Y.; Chien, D.
Comparison of glutathione peroxidase-3 protein expression and enzyme bioactivity in normal subjects and patients with sepsis
Clin. Chim. Acta
489
177-182
2019
Homo sapiens (P22352), Homo sapiens
Manually annotated by BRENDA team
Ramadhani, D.; Suvifan, V.; Purnami, S.; Rahajeng, N.; Lusiyanti, Y.; Wanandi, S.; Wibowo, H.; Miura, T.; Syaifudin, M.
Superoxide dismutase and glutathione peroxidase activities in a population exposed to high indoor radon concentration a preliminary report
Free Radic. Res.
55
1094-1103
2022
Homo sapiens
Manually annotated by BRENDA team