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Information on EC 1.11.1.6 - catalase and Organism(s) Rattus norvegicus and UniProt Accession P04762

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EC Tree
     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.6 catalase
IUBMB Comments
A hemoprotein. A manganese protein containing MnIII in the resting state, which also belongs here, is often called pseudocatalase. The enzymes from some organisms, such as Penicillium simplicissimum, can also act as a peroxidase (EC 1.11.1.7) for which several organic substances, especially ethanol, can act as a hydrogen donor. Enzymes that exhibit both catalase and peroxidase activity belong under EC 1.11.1.21, catalase-peroxidase.
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This record set is specific for:
Rattus norvegicus
UNIPROT: P04762
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The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
hide
2
H2O2
=
O2
+
2
H2O
2
=
+
2
Synonyms
catalase, cat-1, catalase a, manganese catalase, polyethylene glycol-catalase, catalase-1, cat-a, catpo, catalase p, catalase-phenol oxidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
caperase
-
-
-
-
catalase-peroxidase
-
-
-
-
equilase
-
-
-
-
optidase
-
-
-
-
polyethylene glycol-catalase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
hydrogen-peroxide:hydrogen-peroxide oxidoreductase
A hemoprotein. A manganese protein containing MnIII in the resting state, which also belongs here, is often called pseudocatalase. The enzymes from some organisms, such as Penicillium simplicissimum, can also act as a peroxidase (EC 1.11.1.7) for which several organic substances, especially ethanol, can act as a hydrogen donor. Enzymes that exhibit both catalase and peroxidase activity belong under EC 1.11.1.21, catalase-peroxidase.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-05-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
H2O2
O2 + H2O
show the reaction diagram
-
-
-
?
H2O2
O2 + H2O
show the reaction diagram
-
-
-
-
?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
all-trans-retinol
-
treatment of cultured Sertoli cells leads to activation of catalase by increasing its protein content, but without alteration of its mRNA expression. Retinol treatment also increases cell lipoperoxidation and intracellular reactive species production. All effects induced by retinol are inhibited by the antioxidant Trolox
retinal
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retinal (0.007 and 0.014 mM) increases CAT activity after 24 h of treatment
retinoic acid
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retinoic acid (100 nM and 0.001 mM) increases CAT activity after 24 h of treatment
additional information
daidzein shows a significant induction of catalase promoter activity at 0.1 mM in a reporter gene assay and at 0.2 mM in Northern blot experiments
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
the catalase activity in striatum is significantly decreased in the lesioned group as compared to sham group and pretreatment with Withania somnifera reverses its activity significantly and dose dependently in the lesioned goup pretretaed with 100 mg/kg 200 mg/ml or 300 mg/kg body weight extracts of Withania somnifera orally as compared to lesioned group
Manually annotated by BRENDA team
-
diabetic animals treated with BioGHK incorporated collagen (Peptide Incorporated Collagen) show significant higher levels of catalase due to the ability of GHK to attract macrophages and cytokines towards the wound environment
Manually annotated by BRENDA team
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activity increased significantly in the diazinon treated group compared with the control group
Manually annotated by BRENDA team
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catalase activity is decreased dramatically after forebrain ischemia insult, no significant difference in catalase activity between control group and sham-operated group and curcumin-treted group
Manually annotated by BRENDA team
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in azathioprine-treated rats a significant decrease in catalase activity is observed 24 h post-treatment. This inhibition is significantly released with pre-treatment with Hibiscus sabdariffa, Rosmarinus officinalisor Salvia officinalis
Manually annotated by BRENDA team
-
no change in catalase activity after treatment with nicotinamide
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CATA_RAT
527
0
59757
Swiss-Prot
other Location (Reliability: 1)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Akturk, O.; Demirin, H.; Sutcu, R.; Yilmaz, N.; Koylu, H.; Altuntas, I.
The effects of diazinon on lipid peroxidation and antioxidant enzymes in rat heart and ameliorating role of vitamin E and vitamin C
Cell Biol. Toxicol.
22
455-461
2006
Rattus norvegicus
Manually annotated by BRENDA team
Akbas, S.H.; Yegin, A.; Ozben, T.
Effect of pentylenetetrazol-induced epileptic seizure on the antioxidant enzyme activities, glutathione and lipid peroxidation levels in rat erythrocytes and liver tissue
Clin. Biochem.
38
1009-1014
2005
Rattus norvegicus
Manually annotated by BRENDA team
Robertson, M.A.; Finochietto, P.; Gamba, C.A.; Dagrosa, M.A.; Viaggi, M.E.; Franco, M.C.; Poderoso, J.J.; Juvenal, G.J.; Pisarev, M.A.
Nicotinamide increases thyroid radiosensitivity by stimulating nitric oxide synthase expression and the generation of organic peroxides
Horm. Metab. Res.
38
12-15
2006
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Ahmad, M.; Saleem, S.; Abdullah, S.; Ahmad, S.; Ansari, M.A.; Yousef, S.; Hoda, M.N.; Islam, F.
Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats
Hum. Exp. Toxicol.
24
137-147
2005
Rattus norvegicus
Manually annotated by BRENDA team
Amin, A.; Hamza, A.A.
Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia on azathioprine-induced toxicity in rats
Life Sci.
77
266-278
2005
Rattus norvegicus
Manually annotated by BRENDA team
Arul, V.; Kartha, R.; Jayakumar, R.
A therapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices
Life Sci.
80
275-284
2007
Rattus norvegicus
Manually annotated by BRENDA team
Al-Omar, F.A.; Nagi, M.N.; Abdulgadir, M.M.; Al Joni, K.S.; Al-Majed, A.A.
Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus
Neurochem. Res.
31
611-618
2006
Rattus norvegicus
Manually annotated by BRENDA team
Antunes-Neto, J.M.F.; Toyama, M.H.; Carneiro, E.M.; Boschero, A.C.; Pereira-da-Silva, L.; Macedo, D.V.
Circulating leukocyte heat shock protein 70 (HSP70) and oxidative stress markers in rats after a bout of exhaustive exercise
Stress
9
107-115
2006
Rattus norvegicus
Manually annotated by BRENDA team
Gelain, D.P.; de Bittencourt Pasquali, M.A.; Zanotto-Filho, A.; de Souza, L.F.; de Oliveira, R.B.; Klamt, F.; Moreira, J.C.
Retinol increases catalase activity and protein content by a reactive species-dependent mechanism in Sertoli cells
Chem. Biol. Interact.
174
38-43
2008
Rattus norvegicus
Manually annotated by BRENDA team
Kampkoetter, A.; Chovolou, Y.; Kulawik, A.; Roehrdanz, E.; Weber, N.; Proksch, P.; Waetjen, W.
Isoflavone daidzein possesses no antioxidant activities in cell-free assays but induces the antioxidant enzyme catalase
Nutr. Res.
28
620-628
2008
Rattus norvegicus (P04762)
Manually annotated by BRENDA team
Pasquali, M.A.; Gelain, D.P.; Zanotto-Filho, A.; de Souza, L.F.; de Oliveira, R.B.; Klamt, F.; Moreira, J.C.
Retinol and retinoic acid modulate catalase activity in Sertoli cells by distinct and gene expression-independent mechanisms
Toxicol. In Vitro
22
1177-1183
2008
Rattus norvegicus
Manually annotated by BRENDA team