Information on EC 1.11.1.15 - peroxiredoxin

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The expected taxonomic range for this enzyme is: Archaea, Eukaryota, Bacteria

EC NUMBER
COMMENTARY
1.11.1.15
-
RECOMMENDED NAME
GeneOntology No.
peroxiredoxin
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH
show the reaction diagram
-
-
-
-
2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH
show the reaction diagram
the enzyme exhibits a saturable, single-displacement-like reaction mechanism rather than non-saturable double displacement (ping-pong) enzyme substitution mechanism
P91883
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
redox reaction
-
-
PATHWAY
KEGG Link
MetaCyc Link
Glutathione metabolism
-
Metabolic pathways
-
SYSTEMATIC NAME
IUBMB Comments
thiol-containing-reductant:hydroperoxide oxidoreductase
Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [1]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see mechanism). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants (R'-SH) (e.g. thioredoxin, AhpF, tryparedoxin or AhpD), completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond [1]. To recycle the disulfide, known atypical 2-Cys Prxs appear to use thioredoxin as an electron donor [3]. The 1-Cys Prxs conserve only the peroxidatic cysteine, so that its oxidized form is directly reduced to cysteine by the reductant molecule [4].
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
1-Cys peroxiredoxin
A8D0B7
-
1-Cys peroxiredoxin
-
-
1-Cys peroxiredoxin
Burkholderia cenocepacia K56-2
-
-
-
1-Cys peroxiredoxin
-
-
1-Cys peroxiredoxin
-
-
1-Cys peroxiredoxin
-
-
1-Cys peroxiredoxin
-
-
-
1-Cys peroxiredoxin
A1KZ88
-
1-Cys peroxiredoxin
-
-
1-Cys Prx
A8D0B7
-
1-Cys Prx
-
-
1-Cys type Prx
C3VVL6
-
1Cys-peroxiredoxin
-
-
2-Cys peroxiredoxin
Q96291
-
2-Cys peroxiredoxin
Arabidopsis thaliana Columbia
Q96291
-
-
2-Cys peroxiredoxin
Q9FUC5
-
2-Cys peroxiredoxin
-
-
2-Cys peroxiredoxin
-
-
2-Cys peroxiredoxin
P32119
-
2-Cys peroxiredoxin
Q06830
-
2-Cys peroxiredoxin
-
-
2-Cys peroxiredoxin
-
-
2-Cys peroxiredoxin
-
-
2-Cys peroxiredoxin
-
-
2-Cys peroxiredoxin
-
-
2-Cys peroxiredoxin
-
-
2-Cys peroxiredoxin
Q74887
-
2-Cys peroxiredoxin
-
-
2-Cys peroxiredoxin 4
B9USM4
-
2-Cys peroxiredoxin TPx-1
-
-
2-Cys Prx
Q96291
-
2-Cys Prx
Arabidopsis thaliana Columbia
Q96291
-
-
2-Cys Prx
Q9FUC5
-
2-Cys Prx
-
-
2-Cys Prx
-
-
2-Cys Prx
A1KXU3
-
2-Cys type Prx
C3VVL4
-
2-cysteine peroxiredoxin
-
-
25 kDa thiol-specific oxidant
A8R072
formerly
2Cys-peroxiredoxin
Q9SQJ4
-
AbTPx1
B1N693
isozyme
AbTPx2
B1N694
isozyme
Ac-1-Cys Prx
A1KZ88
-
Ahp
-
peroxiredoxin activity is located within the carboxyl-terminal AhpC/thiol-specific antioxidant domain (Ahp) of Rhodospirillum rubrum adenylyltransferase GlnE
AhpC
P0AE08
-
AhpC
P21762
-
AhpC-like peroxiredoxin
O83522
-
AhpC-like Prx
O83522
-
AhpE
-
a 1-Cys peroxiredoxin
Alkyl hydroperoxide reductase
-
-
Alkyl hydroperoxide reductase
O83522
-
alkyl hydroperoxide reductase C component
P0A251
-
AsPrx
Q9NL98
-
atypical 2-Cys peroxiredoxin
-
-
atypical 2-Cys peroxiredoxin
-
-
atypical 2-Cys peroxiredoxin
Saccharomyces cerevisiae YPH250
-
-
-
atypical two-cysteine peroxidase
Q2FXL3
-
atypical two-cysteine peroxidase
Staphylococcus aureus NCTC 8325
Q2FXL3
-
-
bacterioferritin comigratory protein
-
-
bacterioferritin comigratory protein
Burkholderia cenocepacia K56-2
-
-
-
bacterioferritin comigratory protein
-
-
bacterioferritin comigratory protein
Q97WP9
-
bacterioferritin comigratory protein
Q9PER7
-
BCP
Burkholderia cenocepacia K56-2
-
-
-
BCP
Q9PER7
-
Bcp1
Q97WP9
the isozyme is classified as a 2-Cys peroxiredoxin
Bcp3
Q97WG5
the isozyme is classified as a 1-Cys peroxiredoxin
Bcp4
Q97VL0
the isozyme is classified as a 2-Cys peroxiredoxin
Bcp4
Q97VL0
-
-
BiPrx1
C3VVL6
-
BiTPx1
C3VVL4
-
calpromotin
-
-
CIC-Prx
Q8GZT7
-
CPX
-
belongs to the 2-cysteine peroxiredoxin family
DTT-dependent peroxidase
Q97WP9
-
EcTpx
-
an atypical 2Cys Tpx with an intramolecular disulfide bond formed between the peroxidatic Cys61 and the resolving Cys95 residue
GPX1
Saccharomyces cerevisiae YPH250
-
-
-
HBP23/Prx I
-
-
heme-binding protein 23/peroxiredoxin
-
belongs to the 2-Cys peroxiredoxin type I family and exhibits peroxidase activity coupled with reduced thioredoxin as an electron donor
natural killer enhancing factor-B
-
-
NES-Prx1
-
in cytoplasm
NLS-Prx1
-
in nucleus
nuclear export signal-Prx1
-
-
nuclear localization signal-Prx1
-
-
PcPrx-1
Phanerochaete chrysosporium BKM-F-1767
-
-
-
peroxiredoxin
B1N693, B1N694
-
peroxiredoxin
-
-
peroxiredoxin 1
Q06830
-
peroxiredoxin 1
B4XEM9
-
peroxiredoxin 2
-
-
peroxiredoxin 2
-
previously known as torin, calpromotin, NKEF-B, HRPRP, band 8 or TPx-B
peroxiredoxin 2
P32119
-
peroxiredoxin 2
-
-
peroxiredoxin 3
-
a typical 2-Cys peroxiredoxin
peroxiredoxin 4
B9USM4
-
peroxiredoxin 5
-
-
peroxiredoxin 5
-
classified in the atypical 2-Cys subfamily, the oxidized form of the enzyme is characterized by the presence of an intramolecular disulfide bridge between the peroxidatic and the resolving cysteine residues
peroxiredoxin 6
Q1AN22
-
peroxiredoxin 6
-
-
peroxiredoxin 6
O77834
-
peroxiredoxin 6
C5H3W2
-
peroxiredoxin 6
B6RB12
a member of 1-Cys peroxiredoxins
peroxiredoxin 6
-
-
peroxiredoxin 6
P30041
-
peroxiredoxin 6
-
-
peroxiredoxin 6
O08709
-
peroxiredoxin 6
-
-
peroxiredoxin 6
O35244
-
peroxiredoxin 6
Q9TSX9
-
peroxiredoxin 6
-
-
peroxiredoxin I
-
-
peroxiredoxin II
-
-
peroxiredoxin II
Q8S3L0
-
peroxiredoxin III
-
-
peroxiredoxin III
-
-
peroxiredoxin IV
-
-
peroxiredoxin IV
A8R072
-
peroxiredoxin IV
-
-
peroxiredoxin Q
-
-
peroxiredoxin V
B3SP74
an atypical 2-Cys peroxiredoxin
peroxiredoxin VI
-
-
peroxiredoxin-1
-
-
peroxiredoxin-3
-
-
peroxiredoxin-4
Q9Z0V5
-
Pf1-Cys-Prx
-
-
PH1217 protein
O58966
-
PRDX I
Q06830
isozyme
PRDX II
P32119
isozyme
PRDX III
-
isozyme
PRDX III
-
-
PRDX-2
Q8IG31
a 2-Cys peroxiredoxin
PRDX-3
Q21824
a 2-Cys peroxiredoxin
PRDX1
B4XEM9
-
Prdx6
Q1AN22
classified as a 2-Cys PRDX
Prdx6
Q1AN22
PRDX6 is a typical 2-Cys PRDX that functions more like a cytoprotective antioxidant enzyme or a modulator of peroxide-dependent cell signaling rather than a molecular chaperone
Prdx6
-
Prdx6 is the prototype and the only mammalian 1-Cys member of the peroxiredoxin family
Prdx6
O77834
-
Prdx6
-
Prdx6 is the prototype and the only mammalian 1-Cys member of the peroxiredoxin family
Prdx6
P30041
-
Prdx6
-
Prdx6 is the prototype and the only mammalian 1-Cys member of the peroxiredoxin family
Prdx6
O08709
-
Prdx6
-
Prdx6 is the prototype and the only mammalian 1-Cys member of the peroxiredoxin family
Prdx6
Q9TSX9
-
Prx
Q9Y9L0
-
Prx
A8D0B7
-
Prx
B1N693, B1N694
-
Prx
Q06830
-
Prx
A8R072
Prx from Penaeus japonicus belongs to the 2-Cys peroxiredoxin subgroup
Prx
-
belongs to the group of 1-Cys peroxiredoxins, Prx from Thermotoga maritima is part of a natural hybrid protein constituted of two moieties: a peroxiredoxin domain at the N-terminus and a nitroreductase domain at the C-terminus
Prx
Thermus aquaticus YT-1
-
-
-
Prx 2
A9QKS0
-
Prx 3
-
-
Prx 4
B9USM4
-
Prx I
-
-
Prx I
-
2-Cys-Prx
Prx I
Q06830
isozyme
Prx I
-
2-Cys-Prx
Prx I
Q63716
-
Prx II
-
-
Prx II
-
2-Cys-Prx
Prx II
P32119
isozyme
Prx II
-
2-Cys-Prx
Prx II
P35704
-
Prx III
Q9Z0V6
-
PRx IV
-
-
PRx IV
Q13162
isozyme
PRx IV
Q63716
-
Prx V
B3SP74
; PRX V is an atypical 2-Cys PRX that can form intramolecular disulfide bridges through the N-terminal and C-terminal cysteines
Prx V
-
2-Cys-Prx
Prx V
P30044
isozyme
Prx V
-
2-Cys-Prx
Prx V
Q9R063
-
Prx VI
O35244
-
Prx-4
Q9Z0V5
-
Prx1
Q06830
-
Prx1
-
isozyme
Prx1
-
a 1-Cys peroxiredoxin
Prx1
A1KXR1
2-Cys peroxiredoxin isozyme
Prx1
E8VUX3
-
Prx1
E8VUX3
-
-
Prx2
P32119
-
Prx2
E8VQ78
-
Prx2
E8VQ78
-
-
Prx3
-
-
Prx5
-
-
Prx5
-
isozyme
Prx6
C5H3W2
Prx6 belongs to the 1-Cys peroxiredoxin subgroup
PrxII F
A0ZXY5
-
PrxQ
Q9PER7
-
PrxV
-
-
rDiPrx-1
Q9U5A1
-
SAOUHSC_01822
Q2FXL3
-
SAOUHSC_01822
Staphylococcus aureus NCTC 8325
Q2FXL3
-
-
SSO2613
Q97VL0
locus name
SSO2613
Q97VL0
locus name
-
TgTrx-Px1
-
-
TgTrx-Px2
-
-
thiol-specific antioxidant/protector protein
-
-
thioredoxin peroxidase
-
-
thioredoxin peroxidase
B1N693, B1N694
-
thioredoxin peroxidase
B4Y9T5
-
thioredoxin peroxidase
B6V3F6
-
thioredoxin peroxidase
A1KXU3
-
thioredoxin peroxidase 1
-
-
thioredoxin peroxidase B
-
-
thioredoxin peroxidase II
-
-
thioredoxin-dependent alkyl hydroperoxide reductase
P21762
-
thioredoxin-dependent peroxidase
-
-
torin
-
-
TP0509
O83522
gene name
Tpx
B6V3F6
-
TPx II
-
isozyme
TPx-1
-
a 2-Cys peroxiredoxin
TPx-B
-
-
tryparedoxin peroxidase
-
-
tryparedoxin peroxidase
-
-
tryparedoxin/peroxynitrite oxidoreductase
-
-
Ts2-CysPrx
-
-
TSA
A8R072
formerly
TSA thioredoxin peroxidase Tpx
A8R072
formerly
Tsa1
-
has dual activities as a peroxidase and as a molecular chaperone, Tsa1 functions predominantly as an antioxidant in protecting both the cytosol and actively translating ribosomes against endogenous reactive oxygen species, but shifts towards its chaperone function in response to oxidative stress conditions
TsaA
E8VQ78
-
TsaA
E8VQ78
-
-
two-cysteine peroxiredoxin
Q74887
-
type II peroxiredoxin
-
-
type II peroxiredoxin
-
-
type II peroxiredoxin
-
-
type II peroxiredoxin F
-
-
typical 2-Cys peroxiredoxin
A9QKS0
-
typical 2-Cys Prx
B9USM4
-
typical 2-Cys Prx
O83522
-
additional information
-
the 1-Cys peroxiredoxin belongs to the subdivision of the bacterioferritin comigratory protein family of bacterial peroxiredoxins
additional information
Burkholderia cenocepacia K56-2
-
the 1-Cys peroxiredoxin belongs to the subdivision of the bacterioferritin comigratory protein family of bacterial peroxiredoxins
-
additional information
-
the atypical 2-Cys peroxiredoxin belongs to the subdivision of the bacterioferritin comigratory protein family of bacterial peroxiredoxins
additional information
O83522
the enzyme belongs to the peroxiredoxin enzyme family
additional information
Q9PER7
peroxiredoxin PrxQ belongs to the subdivision of the bacterioferritin comigratory protein family of bacterial peroxiredoxins
CAS REGISTRY NUMBER
COMMENTARY
207137-51-7
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
strain K1
-
-
Manually annotated by BRENDA team
strain K1
UniProt
Manually annotated by BRENDA team
ecotype Columbia
-
-
Manually annotated by BRENDA team
Arabidopsis thaliana Columbia
-
UniProt
Manually annotated by BRENDA team
isoform peroxiredoxin 6
UniProt
Manually annotated by BRENDA team
-
Swissprot
Manually annotated by BRENDA team
BiPrx1; gene BiPrx1 encoding a 1-Cys type Prx
UniProt
Manually annotated by BRENDA team
BiTPrx1; gene BiTPx1 encoding a 2-Cys type Prx
UniProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
subsp. pekinensis
SwissProt
Manually annotated by BRENDA team
Burkholderia cenocepacia K56-2
-
-
-
Manually annotated by BRENDA team
Zhikong scallop
UniProt
Manually annotated by BRENDA team
Chinese mitten crab
UniProt
Manually annotated by BRENDA team
disk abalone
B1N693, B1N694
UniProt
Manually annotated by BRENDA team
var. Gerbel
-
-
Manually annotated by BRENDA team
tammar wallaby
UniProt
Manually annotated by BRENDA team
kuruma shrimp
UniProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
natural hybrid protein which contains both a peroxiredoxin and a glutaredoxin domain
-
-
Manually annotated by BRENDA team
L. cv. Dong-jin
-
-
Manually annotated by BRENDA team
Phanerochaete chrysosporium BKM-F-1767
BKM-F-1767
-
-
Manually annotated by BRENDA team
1-Cys peroxiredoxin
SwissProt
Manually annotated by BRENDA team
2-Cys peroxiredoxin
SwissProt
Manually annotated by BRENDA team
isoform peroxiredoxin 1
UniProt
Manually annotated by BRENDA team
Populus tremula x Populus tremuloides
SwissProt
Manually annotated by BRENDA team
sheep scab mite
UniProt
Manually annotated by BRENDA team
isozyme Gpx1
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae YPH250
isozyme Gpx1
-
-
Manually annotated by BRENDA team
Staphylococcus aureus NCTC 8325
-
UniProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
i.e. Taiwanofungus camphoratus
SwissProt
Manually annotated by BRENDA team
Thermus aquaticus YT-1
YT-1
-
-
Manually annotated by BRENDA team
gene TP0509
UniProt
Manually annotated by BRENDA team
gene prxq or bcp
UniProt
Manually annotated by BRENDA team
IC50 VALUE [mM]
IC50 VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.294
-
H2O2
-
MPX, at 28C
0.3
-
H2O2
-
CPX, at 28C
0.4
-
peroxynitrite
-
MPX, at 28C
0.48
-
peroxynitrite
-
CPX, at 28C
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
4
10
B1N693, B1N694
;
5.4
9
A1KZ88, -
no activity at or below pH 5.4, optimal activity at pH 9.0
PDB
SCOP
CATH
ORGANISM
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Helicobacter pylori (strain J99 / ATCC 700824)
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Xylella fastidiosa (strain 9a5c)
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
4C, stable for several weeks
-