Information on EC 1.10.99.2 - ribosyldihydronicotinamide dehydrogenase (quinone)

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The expected taxonomic range for this enzyme is: Eutheria

EC NUMBER
COMMENTARY
1.10.99.2
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RECOMMENDED NAME
GeneOntology No.
ribosyldihydronicotinamide dehydrogenase (quinone)
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase
A flavoprotein. Unlike EC 1.6.5.2, NAD(P)H dehydrogenase (quinone), this quinone reductase cannot use NADH or NADPH; instead it uses N-ribosyl- and N-alkyldihydronicotinamides. Polycyclic aromatic hydrocarbons, such as benz[a]anthracene, and the oestrogens 17beta-estradiol and diethylstilbestrol are potent inhibitors, but dicoumarol is only a very weak inhibitor [2]. This enzyme can catalyse both 2-electron and 4-electron reductions, but one-electron acceptors, such as potassium ferricyanide, cannot be reduced [3].
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
bQR2
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dihydronicotinamide riboside:quinone oxidoreductase 2
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dihydronicotinamide riboside:quinone reductase 2
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melatonin-binding site MT3
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MT3
P16083
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MT3/NQO2
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N-ribosyldihydronicotinamide dehydrogenase (quinone)
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N-ribosyldihydronicotinamide:quinone oxidoreductase 2
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NQO2
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NQO2
Q9JI75
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NRH-oxidizing enzyme
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NRH:QR2
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NRH:quinone oxidoreductase
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NRH:quinone oxidoreductase
Q9JI75
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NRH:quinone oxidoreductase 2
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NRH:quinone oxidoreductase 2
P16083
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NRH:quinone oxidoreductase 2
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NRH:quinone oxidoreductase 2
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NRH:quinone oxireductase 2
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NRH:quinone reductase 2
P16083
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NRH:quinone reductase 2
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QR2
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QR2
P16083
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quinone oxidoreductase 2
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quinone reductase 2
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quinone reductase 2
P16083
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quinone reductase 2
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quinone reductase 2
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quinone reductase 2
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quinone reductase type 2
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CAS REGISTRY NUMBER
COMMENTARY
667919-86-0
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
comparison with quinone reductase 1
SwissProt
Manually annotated by BRENDA team
expressed in CHO cells
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Manually annotated by BRENDA team
recombinant
SwissProt
Manually annotated by BRENDA team
recombinant
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Manually annotated by BRENDA team
stably expressed in CHO cells
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Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM