Information on EC 1.10.3.5 - 3-hydroxyanthranilate oxidase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
1.10.3.5
-
RECOMMENDED NAME
GeneOntology No.
3-hydroxyanthranilate oxidase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
3-hydroxyanthranilate:oxygen oxidoreductase
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
3-hydroxyanthranilic acid dioxygenase
-
-
3-hydroxyanthranilic acid oxidase
-
-
-
-
3HAO
Rattus norvegicus Sprague-Dawley
-
-
-
o-aminophenol:O2 oxidoreductase
-
-
phenoxazine-synthetase
-
-
CAS REGISTRY NUMBER
COMMENTARY
37256-53-4
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
american alligator
-
-
Manually annotated by BRENDA team
salamander, two-toad amphiuma
-
-
Manually annotated by BRENDA team
beef, cow, calf
-
-
Manually annotated by BRENDA team
cane toad
-
-
Manually annotated by BRENDA team
guinea pig
-
-
Manually annotated by BRENDA team
snapping turtle
-
-
Manually annotated by BRENDA team
chicken
-
-
Manually annotated by BRENDA team
mouse, Swiss mice
-
-
Manually annotated by BRENDA team
rainbow trout
-
-
Manually annotated by BRENDA team
sheep
-
-
Manually annotated by BRENDA team
turtle, red-eared slider
-
-
Manually annotated by BRENDA team
Sprague-Dawley
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
Sprague-Dawley
-
-
Manually annotated by BRENDA team
Rattus norvegicus Wistar
Wistar
-
-
Manually annotated by BRENDA team
eastern box turtle
-
-
Manually annotated by BRENDA team
turtle, florida cooter
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
Rattus norvegicus Sprague-Dawley
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
Rattus norvegicus Wistar
-
-
-
-
?
3-hydroxy-4-methylanthranilic acid + O2
actinocin
show the reaction diagram
-
-
-
-
?
3-hydroxy-4-methylanthranilic acid + O2
actinocin
show the reaction diagram
-
-
-
?
3-hydroxy-L-kynurenine + O2
(2S)-2-amino-4-(6-imino-5-oxocyclohexa-1,3-dien-1yl)-4-oxo-butanoic acid + H2O2
show the reaction diagram
-
-
-
-
?
3-hydroxy-L-kynurenine + O2
(2S)-2-amino-4-(6-imino-5-oxocyclohexa-1,3-dien-1yl)-4-oxo-butanoic acid + H2O2
show the reaction diagram
Rattus norvegicus Wistar
-
-
-
-
?
3-hydroxyanthranilic acid + O2
2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2
show the reaction diagram
-
-
cinnabarinic acid, oxidative dimerization
?
o-aminophenol + O2
phenoxazinone + H2O2
show the reaction diagram
-
-
-
-
?
ethyl-3-hydroxyanthranilate + O2
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
2-amino-3-hydroxytoluene is no substrate
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
3-hydroxyanthranilic acid + O2
2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2
show the reaction diagram
-
-
cinnabarinic acid, oxidative dimerization
?
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
4-Chloro-3-hydroxyanthranilate
-
irreversible inhibition
4-Chloro-3-hydroxyanthranilate
-
-
alpha,alpha'-dipyridyl
-
-
ATP
-
8% inhibition
CTP
-
16% inhibition
dATP
-
4% inhibition
dCTP
-
20% inhibition
dGTP
-
24% inhibition
GTP
-
20% inhibition
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
O2
-
breathing oxygen at pressures above atmosphere
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.014
-
3-Hydroxyanthranilate
-
air used as source of oxygen
0.05
-
3-Hydroxyanthranilate
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
0.03
-
-
thymus tissue, 0.008 M substrate
0.034
-
-
thymus tissue, 0.001 M substrate
0.037
-
-
spleen tissue, 0.001 M substrate
0.047
-
-
thymus tissue, 0.004 M substrate
0.07
-
-
regenerating liver
0.134
-
-
kidney tissue, 0.001 M substrate
0.16
-
-
-
0.185
-
-
-
0.212
-
-
female
0.24
-
-
-
0.25
-
-
liver tissue
0.264
-
-
male
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
Rattus norvegicus Sprague-Dawley
-
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley, Rattus norvegicus Wistar
-
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
-
;
-
Manually annotated by BRENDA team
Rattus norvegicus Wistar
-
-
-
Manually annotated by BRENDA team
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
-20°C, can be stored for several months with no detectable inactivation
-
20°C, shows little loss of activity at room temperature
-
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
APPLICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
medicine
-
enzyme activity increases in the brains of Huntington disease victims