Information on EC 1.10.3.5 - 3-hydroxyanthranilate oxidase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
1.10.3.5
-
RECOMMENDED NAME
GeneOntology No.
3-hydroxyanthranilate oxidase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
3-hydroxyanthranilate:oxygen oxidoreductase
-
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
3-hydroxyanthranilic acid dioxygenase
-
-
3-hydroxyanthranilic acid oxidase
-
-
-
-
3HAO
Rattus norvegicus Sprague-Dawley
-
-
-
o-aminophenol:O2 oxidoreductase
-
-
phenoxazine-synthetase
-
-
CAS REGISTRY NUMBER
COMMENTARY
37256-53-4
-
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
american alligator
-
-
Manually annotated by BRENDA team
salamander, two-toad amphiuma
-
-
Manually annotated by BRENDA team
beef, cow, calf
-
-
Manually annotated by BRENDA team
guinea pig
-
-
Manually annotated by BRENDA team
snapping turtle
-
-
Manually annotated by BRENDA team
chicken
-
-
Manually annotated by BRENDA team
mouse, Swiss mice
-
-
Manually annotated by BRENDA team
rainbow trout
-
-
Manually annotated by BRENDA team
sheep
-
-
Manually annotated by BRENDA team
turtle, red-eared slider
-
-
Manually annotated by BRENDA team
Sprague-Dawley
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
Sprague-Dawley
-
-
Manually annotated by BRENDA team
Rattus norvegicus Wistar
Wistar
-
-
Manually annotated by BRENDA team
cane toad
-
-
Manually annotated by BRENDA team
eastern box turtle
-
-
Manually annotated by BRENDA team
turtle, florida cooter
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
Rattus norvegicus Sprague-Dawley
-
-
-
-
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
Rattus norvegicus Wistar
-
-
-
-
?
3-hydroxy-4-methylanthranilic acid + O2
actinocin
show the reaction diagram
-
-
-
-
?
3-hydroxy-4-methylanthranilic acid + O2
actinocin
show the reaction diagram
-
-
-
?
3-hydroxy-L-kynurenine + O2
(2S)-2-amino-4-(6-imino-5-oxocyclohexa-1,3-dien-1yl)-4-oxo-butanoic acid + H2O2
show the reaction diagram
-
-
-
-
?
3-hydroxy-L-kynurenine + O2
(2S)-2-amino-4-(6-imino-5-oxocyclohexa-1,3-dien-1yl)-4-oxo-butanoic acid + H2O2
show the reaction diagram
Rattus norvegicus Wistar
-
-
-
-
?
3-hydroxyanthranilic acid + O2
2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2
show the reaction diagram
-
-
cinnabarinic acid, oxidative dimerization
?
o-aminophenol + O2
phenoxazinone + H2O2
show the reaction diagram
-
-
-
-
?
ethyl-3-hydroxyanthranilate + O2
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
2-amino-3-hydroxytoluene is no substrate
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
show the reaction diagram
-
-
-
-
?
3-hydroxyanthranilic acid + O2
2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2
show the reaction diagram
-
-
cinnabarinic acid, oxidative dimerization
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
4-Chloro-3-hydroxyanthranilate
-
irreversible inhibition
4-Chloro-3-hydroxyanthranilate
-
-
alpha,alpha'-dipyridyl
-
-
ATP
-
8% inhibition
CTP
-
16% inhibition
dATP
-
4% inhibition
dCTP
-
20% inhibition
dGTP
-
24% inhibition
GTP
-
20% inhibition
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
O2
-
breathing oxygen at pressures above atmosphere
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.014
3-Hydroxyanthranilate
-
air used as source of oxygen
0.05
3-Hydroxyanthranilate
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.03
-
thymus tissue, 0.008 M substrate
0.034
-
thymus tissue, 0.001 M substrate
0.037
-
spleen tissue, 0.001 M substrate
0.047
-
thymus tissue, 0.004 M substrate
0.07
-
regenerating liver
0.134
-
kidney tissue, 0.001 M substrate
0.16
-
-
0.185
-
-
0.212
-
female
0.24
-
-
0.25
-
liver tissue
0.264
-
male
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.2 - 7.4
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.5 - 8.5
-
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
Rattus norvegicus Sprague-Dawley
-
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley, Rattus norvegicus Wistar
-
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley, Rattus norvegicus Wistar
-
-
-
Manually annotated by BRENDA team
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, can be stored for several months with no detectable inactivation
-
20°C, shows little loss of activity at room temperature
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
-
enzyme activity increases in the brains of Huntington disease victims