Information on EC 1.10.2.2 - quinol-cytochrome-c reductase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
1.10.2.2
-
RECOMMENDED NAME
GeneOntology No.
quinol-cytochrome-c reductase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
aerobic respiration I (cytochrome c)
-
-
aerobic respiration II (cytochrome c) (yeast)
-
-
ammonia oxidation IV (autotrophic ammonia oxidizers)
-
-
Fe(II) oxidation
-
-
Metabolic pathways
-
-
oxidative phosphorylation
-
-
Oxidative phosphorylation
-
-
SYSTEMATIC NAME
IUBMB Comments
quinol:ferricytochrome-c oxidoreductase
The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. The mammalian enzyme contains cytochromes b-562, b-566 and c1, and a 2-iron ferredoxin. Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non-cytoplasmic compartment (cf. EC 1.6.99.3, NADH dehydrogenase).
CAS REGISTRY NUMBER
COMMENTARY hide
9027-03-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
hyperthermophile Knallgasbacterium
-
-
Manually annotated by BRENDA team
thermophilic strain PS3
-
-
Manually annotated by BRENDA team
pigeon
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
chicken
-
-
Manually annotated by BRENDA team
Jerusalem artichoke
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
wild-type 74A
-
-
Manually annotated by BRENDA team
Neurospora crassa SL 74OR23-1A FGSC No. 987
strain SL 74OR23-1A FGSC No. 987
-
-
Manually annotated by BRENDA team
strain PCC 7906
-
-
Manually annotated by BRENDA team
rabbit
-
-
Manually annotated by BRENDA team
sheep
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Tn5 mutant CFN4205
-
-
Manually annotated by BRENDA team
formerly Rhodopseudomonas blastica
-
-
Manually annotated by BRENDA team
Rhodobacter capsulatus pMTO-404/MTRKB1
strain pMTO-404/MTRKB1
-
-
Manually annotated by BRENDA team
strain SB1003
-
-
Manually annotated by BRENDA team
strain BC17, BH6, CH6
-
-
Manually annotated by BRENDA team
strain R-26, blue-green mutant
-
-
Manually annotated by BRENDA team
strain Morita
-
-
Manually annotated by BRENDA team
strain Morita
-
-
Manually annotated by BRENDA team
strain S1
-
-
Manually annotated by BRENDA team
wild-type starin S1, mutant strain SdeltaC2
-
-
Manually annotated by BRENDA team
strain NCYC74, derived from Saccharomyces cerevisiae KL14-4A
-
-
Manually annotated by BRENDA team
strain D 273-10B
-
-
Manually annotated by BRENDA team
strain DL1
-
-
Manually annotated by BRENDA team
strain FL100
-
-
Manually annotated by BRENDA team
strain KM91
-
-
Manually annotated by BRENDA team
potato
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,3-dimethoxy-5-methyl-6-(10-bromodecyl)-1,4-benzoquinol + cytochrome c
2,3-dimethoxy-5-methyl-6-(10-bromodecyl)-1,4-benzoquinone + reduced cytochrome c
show the reaction diagram
-
-
-
-
?
2,3-dimethoxy-5-methyl-6-decylbenzoquinol + cytochrome c
2,3-dimethoxy-5-methyl-6-decylbenzoquinone + reduced cytochrome c
show the reaction diagram
-
-
-
-
?
2-azido-3-methyl-5-methoxy-6-geranyl-1,4-benzoquinone + cytochrome c1
?
show the reaction diagram
2-[(7E,11E,15E,19E,23E,27E,31E,35E)-4-hydroxy-4,8,12,16,20,24,28,32,36,40-decamethyl-7,11,15,19,23,27,31,35,39-hentetracontanonaen-1-yl]-5,6-dimethoxy-3-methyl-1,4-benzenediol + oxidized cytochrome c
2-[(7E,11E,15E,19E,23E,27E,31E,35E)-4-hydroxy-4,8,12,16,20,24,28,32,36,40-decamethylhentetraconta-7,11,15,19,23,27,31,35,39-nonaen-1-yl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione + reduced cytochrome c
show the reaction diagram
-
ubiquinone-like compound with a hydroxyl-substituted side chain exhibits substrate efficiencies below that of native ubiquinone but significantly higher efficiency than alpha-tocopheryl quinone
-
-
?
3-azido-2-methyl-5-methoxy-6-geranyl-1,4-benzoquinone + cytochrome c1
?
show the reaction diagram
alpha-tocopheryl hydroquinone + cytochrome c
?
show the reaction diagram
-
-
-
-
?
coenzyme Q1H2 + 2 cytochrome c/ox
coenzyme Q1 + 2 cytochrome c/red + 2 H+
show the reaction diagram
coenzyme ubiquinone 10 + cytochrome c
ubiquinol-50 + cytochrome c
show the reaction diagram
cytochrome b561 + ?
?
show the reaction diagram
-
cytochrome b561, reduced upon flash excitation, is re-oxidized slowly even in the absence of antimycin
-
-
?
cytochrome c551 + ?
?
show the reaction diagram
-
-
-
-
?
decyl-ubiquinol + ferricytochrome c
decyl-ubiquinone + ferrocytochrome c
show the reaction diagram
decylplastoquinol + cytochrome c
decylplastoquinone + reduced cytochrome c
show the reaction diagram
decylubiquinol + 2 ferricytochrome c
decylubiquinone + 2 ferrocytochrome c + 2 H+
show the reaction diagram
-
-
-
-
?
decylubiquinol + ferricytochrome c
decylubiquinone + ferrocytochrome c
show the reaction diagram
dihydroubiquinone + ferricytochrome c
ubiquinone + ferrocytochrome c + 2 H+
show the reaction diagram
-
-
-
?
menaquinol + cytochrome c
menaquinone + reduced cytochrome c
show the reaction diagram
-
-
-
-
?
naphthoquinol + ferricytochrome c
naphthoquinone + ferrocytochrome c
show the reaction diagram
-
-
naphthoquinone is the pool quinone of the organism
-
?
nonylubiquinol + cytochrome c
nonylubiquinone + reduced cytochrome c
show the reaction diagram
plastohydroquinol + cytochrome c
plastohydroquinone + reduced cytochrome c
show the reaction diagram
plastoquinol 1 + cytochrome c
plastoquinone 1 + reduced cytochrome c
show the reaction diagram
-
-
-
-
?
plastoquinol 9 + cytochrome c
plastoquinone 9 + reduced cytochrome c
show the reaction diagram
-
-
-
-
?
QH2 + ferricytochrome c
Q + ferrocytochrome c
show the reaction diagram
quinol + 2 ferricytochrome c
quinone + 2 ferrocytochrome c + 2 H+
show the reaction diagram
rhodoquinol-3 + ferricytochrome c
rhodoquinone + ferrocytochrome c
show the reaction diagram
-
a substrate-induced wQ-cycle bypass reaction leading to production of superoxide
i.e. 2-amino-5-farnesyl-3-methoxy-6-methyl-1,4-benzoquinone
-
?
tetramethyl-p-benzoquinol + cytochrome c
tetramethyl-p-benzoquinone + reduced cytochrome c
show the reaction diagram
-
duroquinol
-
-
?
ubideuteroquinol + cytochrome c
ubideuteroquinone + reduced cytochrome c
show the reaction diagram
ubihydroquinol + cytochrome c
ubihydroquinone + reduced cytochrome c
show the reaction diagram
ubiquinol + 2 ferricyanide
ubiquinone + 2 ferrocyanide + 2 H+
show the reaction diagram
ubiquinol + 2 ferricytochrome c
ubiquinone + 2 ferrocytochrome c + 2 H+
show the reaction diagram
ubiquinol + 2 ferricytochrome c552
ubiquinone + 2 ferrocytochrome c552 + 2 H+
show the reaction diagram
-
-
-
?
ubiquinol + 4-carboxy-2,6-dinitrophenyllysine27-cytochrome c
ubiquinone + ?
show the reaction diagram
-
cytochrome c from horse, modified at Lys27
-
-
?
ubiquinol + cytochrome c
?
show the reaction diagram
-
-
-
-
?
ubiquinol + cytochrome c
ubiquinone + reduced cytochrome c
show the reaction diagram
ubiquinol + cytochrome c2
ubiquinone + reduced cytochrome c2
show the reaction diagram
ubiquinol + ferricytochrome b-561
ubiquinone + ferrocytochrome b-561
show the reaction diagram
ubiquinol + ferricytochrome b-562
ubiquinone + ferrocytochrome b-562
show the reaction diagram
-
-
-
-
?
ubiquinol + ferricytochrome c
ubiquinone + ferrocytochrome c
show the reaction diagram
ubiquinol + horse heart cytochrome c
?
show the reaction diagram
ubiquinol + plastocyanin
?
show the reaction diagram
-
-
-
-
?
ubiquinol 10 + cytochrome c
ubiquinone 10 + reduced cytochrome c
show the reaction diagram
ubiquinol 2 + cytochrome c
ubiquinone 2 + reduced cytochrome c
show the reaction diagram
ubiquinol 3 + cytochrome c
ubiquinone 3 + reduced cytochrome c
show the reaction diagram
-
-
-
-
?
ubiquinol 4 + cytochrome c
ubiquinone 4 + reduced cytochrome c
show the reaction diagram
ubiquinol 9 + cytochrome c
ubiquinone 9 + reduced cytochrome c
show the reaction diagram
ubiquinol-1 + cytochrome c
ubiquinone-1 + reduced cytochrome c
show the reaction diagram
ubiquinol-2 + ferricytochrome c
ubiquinone-2 + ferrocytochrome c
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
coenzyme ubiquinone 10 + cytochrome c
ubiquinol-50 + cytochrome c
show the reaction diagram
naphthoquinol + ferricytochrome c
naphthoquinone + ferrocytochrome c
show the reaction diagram
-
-
naphthoquinone is the pool quinone of the organism
-
?
QH2 + ferricytochrome c
Q + ferrocytochrome c
show the reaction diagram
quinol + 2 ferricytochrome c
quinone + 2 ferrocytochrome c + 2 H+
show the reaction diagram
ubiquinol + 2 ferricytochrome c
ubiquinone + 2 ferrocytochrome c + 2 H+
show the reaction diagram
ubiquinol + 2 ferricytochrome c552
ubiquinone + 2 ferrocytochrome c552 + 2 H+
show the reaction diagram
P05418
-
-
-
?
ubiquinol + cytochrome c
ubiquinone + reduced cytochrome c
show the reaction diagram
-
-
-
-
?
ubiquinol + ferricytochrome c
ubiquinone + ferrocytochrome c
show the reaction diagram
ubiquinol-2 + ferricytochrome c
ubiquinone-2 + ferrocytochrome c
show the reaction diagram
-
the cytochrome bc1 complex is the central segment of the respiratory chain in mitochondria
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
bacteriochlorophyll
-
-
cytochrome b
cytochrome b-561
-
-
-
cytochrome b-562
cytochrome b-565
-
-
-
cytochrome c-552
cytochrome c-553
-
-
-
cytochrome c1
heme b
-
prosthetic group
heme c
-
prosthetic group
Phospholipid
semiquinone
-
antimycin-sensitive prosthetic group
ubi-semiquinone
-
-
ubiquinone
additional information
-
all the bc1 complexes contain three redox prosthetic group bearing subunits (cytochrome b, cytochrome c1, and Rieske iron-sulfur protein) with varying numbers (ranging from 0 to 8) of non-redox prosthetic group bearing (supernumerary) subunits
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Iron-sulfur cluster
Mg2+
-
lowers the substrate binding affinities
additional information
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,3,4-trimethoxy-5-decyl-6-methyl-phenol
-
competitive inhibitor, binds stably to the Qo site of the cytochrome bc1 complex, binding structure, inhibitory potency depends on the chain length of the ubiquinol substrate and is higher with Q0C5 than with Q0C10, inhibition is pH-dependent
2,3,4-trimethoxy-5-methyl-6-decyl-phenol
-
competitive inhibitor, binds stably to the Qo site of the cytochrome bc1 complex, binding structure, inhibition is pH-dependent
2,5-dibromo-3-methyl-6-isopropylbenzoquinone
-
-
2,5-dibromo-6-methyl-3-isopropyl-1,4-benzoquinone
2-alkyl-3-hydroxy-1,4-naphthoquinone
-
-
2-heptyl-4-hydroxyquinoline N-oxide
2-Heptyl-4-hydroxyquinoline-N-oxide
2-Iodo-6-isopropyl-3-methyl-2',2,4'-trinitrodiphenyl ether
-
-
2-nonyl-4-hydroxyquinoline N-oxide
-
binding interaction with cytochrome b, and structural changes of the latter upon binding of inhibitor at the Qi side, overview
2-nonyl-4-hydroxyquinoline-N-oxide
-
-
3-[(2,4-diethylphenyl)amino]-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione
-
-
3-[(2,6-diethylphenyl)amino]-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione
-
-
3-[(2-bromo-4-fluorophenyl)amino]-5-(6-bromopyridin-3-yl)-5-methyl-1,3-oxazolidine-2,4-dione
-
-
3-[(2-bromo-4-fluorophenyl)amino]-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione
-
-
3-[(4-bromophenyl)amino]-5-(6-bromopyridin-3-yl)-5-methyl-1,3-oxazolidine-2,4-dione
-
-
3-[(4-bromophenyl)amino]-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione
-
-
3-[(4-chlorophenyl)amino]-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione
-
-
3-[(4-methoxyphenyl)amino]-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione
-
-
3-[3H]azido-2-methyl-5-methoxy-6-geranyl-1,4-benzoquinone
-
azidoQ
3-[[5-methyl-2,4-dioxo-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidin-3-yl]amino]benzoic acid
-
-
4-[[5-(6-bromopyridin-3-yl)-5-methyl-2,4-dioxo-1,3-oxazolidin-3-yl]amino]benzonitrile
-
-
4-[[5-methyl-2,4-dioxo-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidin-3-yl]amino]benzoic acid
-
-
4-[[5-methyl-2,4-dioxo-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidin-3-yl]amino]benzonitrile
-
-
5-(6-bromopyridin-3-yl)-3-[(2,4-diethylphenyl)amino]-5-methyl-1,3-oxazolidine-2,4-dione
-
-
5-(6-bromopyridin-3-yl)-3-[(2,6-diethylphenyl)amino]-5-methyl-1,3-oxazolidine-2,4-dione
-
-
5-(6-bromopyridin-3-yl)-3-[(4-chlorophenyl)amino]-5-methyl-1,3-oxazolidine-2,4-dione
-
-
5-(6-bromopyridin-3-yl)-3-[(4-methoxyphenyl)amino]-5-methyl-1,3-oxazolidine-2,4-dione
-
-
5-(6-bromopyridin-3-yl)-5-methyl-3-(phenylamino)-1,3-oxazolidine-2,4-dione
-
-
5-(6-bromopyridin-3-yl)-5-methyl-3-[(2-methyl-4-nitrophenyl)amino]-1,3-oxazolidine-2,4-dione
-
-
5-(6-bromopyridin-3-yl)-5-methyl-3-[(4-methylphenyl)amino]-1,3-oxazolidine-2,4-dione
-
-
5-(6-bromopyridin-3-yl)-5-methyl-3-[[4-(trifluoromethyl)phenyl]amino]-1,3-oxazolidine-2,4-dione
-
-
5-methyl-3-[(4-methylphenyl)amino]-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione
-
-
5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-2,4-oxazolidinedione
-
i.e. famoxadone, noncompetitive inhibitor with respect to the substrate of cytochrome c, but is a competitive inhibitor with respect to the substrate of decylubiquinol
5-methyl-5-(6-phenoxypyridin-3-yl)-3-[[4-(trifluoromethyl)phenyl]amino]-1,3-oxazolidine-2,4-dione
-
-
5-n-heptyl-6-hydroxy-4,7-dioxobenzothiazole
-
competitive, structure of the enzyme with the hydroxyquinone anion Qo site inhibitor bound, binding mechanism
5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole
5-undecyl-6-hydroxy-4,7-dioxobenzothiazol
5-Undecyl-6-hydroxy-4,7-dioxobenzothiazole
Antimycin
antimycin A
antimycin A1
-
binding interaction with cytochrome b, and structural changes of the latter upon binding of inhibitor at the Qi side, overview
antimycin-A
-
strong inhibition of Q-cycle bypass reactions
ascorbate
-
-
atovaquone
-
an anti-malarial agent that specifically targets the cytochrome bc1 complex and inhibits parasite respiration in vivo, mutants Y279S, Y279C, and L282V are resistant to the inhibition, modeling the variations in cytochrome b structure and atovaquone binding with the mutated bc1 complexes
azoxystrobin
-
noncompetitive inhibitor with respect to the substrate of cytochrome c, but is a competitive inhibitor with respect to the substrate of decylubiquinol
famoxadone
funiculosin
hydroxyapatite
-
-
ilicicolin H
menaquinol
methoxyacrylate stilbene
methoxyacrylate-stilbene
-
-
Myxothiazol
myxothiazole
-
-
N,N'-dicyclohexylcarbodiimide
-
-
n-2-heptyl-1-hydroxyquinoline N-oxide
-
-
n-alkyl-6-hydroxy-4,7-dioxobenzothiazole
-
length of side chain 7-15 carbon atoms
n-heptyl-4-hydroxyquinoline-N-oxide
-
-
Phospholipase A2
-
-
-
Stigmatellin
Triton X-100
-
-
undecyl-hydroxy-dioxobenzoxythiazole
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Antimycin
asolectin
dodecyl maltoside
ilicicolin
-
stimulation at low inhibitor/enzyme ratio
lecithin
-
soybean
O2
-
molecular oxygen increases the activity of Rhodobacter sphaeroides bc1 complex up to 82%, depending on the intactness of the complex. Since oxygen enhances the reduction rate of heme bL, but shows no effect on the reduction rate of heme bH, the effect of oxygen in the electron transfer sequence of the cytochrome bc1 complex is at the step of heme bL reduction during bifurcated oxidation of ubiquinol. Free superoxide anion is not involved in the oxygen enhanced reduction of heme bL
Sucrose
-
required for full in vitro activity, at 250 mM
Tween 20
-
required for full in vitro activity, at 0.01%
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0046
coenzyme Q1H2
-
estimated value of KM, descriptive of rotenone-dicumarol-insensitive CoQ1 reduction and CoQ1H2 oxidation on passage through normoxic lungs
0.004 - 0.025
cytochrome c
0.001 - 0.03
cytochrome c2
0.01 - 12.4
decylubiquinol
0.006 - 0.025
horse heart cytochrome c
0.008 - 0.072
QH2
0.005
rhodoquinol-3
-
pH 8.0, 23C
0.001 - 0.02
ubiquinol
0.0064 - 0.08
ubiquinol-1
0.004 - 0.038
ubiquinol-10
0.002 - 0.0054
ubiquinol-2
additional information
additional information
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
66.7
2,3-Dimethoxy-5-methyl-6-(10-bromodecyl)-1,4-benzoquinol
Rhodospirillum rubrum
-
-
140 - 240
Abz-VAA
Saccharomyces cerevisiae
-
different purified enzyme preparations, in 0.01% Tween 20, 250 mM sucrose
-
7.83 - 919
cytochrome c
0.133 - 66.7
cytochrome c1
65 - 143
decylubiquinol
4.17 - 5
horse heart cytochrome c1
Rhodobacter sphaeroides
-
-
-
10 - 220
QH2
76
rhodoquinol-3
Saccharomyces cerevisiae
-
pH 8.0, 23C
28.3
ubihydroquinone
Bos taurus
-
-
140 - 160
ubiquinol
Saccharomyces cerevisiae
-
pH 7.0, 22C
additional information
additional information
Saccharomyces cerevisiae
-
rate of direct heme-to-heme electron transfer from the enzyme complex cytochrome c1 to cytochrome c
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0068
2,3,4-trimethoxy-5-decyl-6-methyl-phenol
-
pH 7.4, 25C
0.0716
2,3,4-trimethoxy-5-methyl-6-decyl-phenol
-
pH 7.4, 25C
0.000329
3-[(4-bromophenyl)amino]-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione
-
pH 7.4, 23C
0.00000362 - 0.00005143
5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-2,4-oxazolidinedione
0.0000025
Antimycin
-
pH 7.0, 22C
0.000195
famoxadone
-
pH 7.2, 25C
0.0000025 - 0.00005
ilicicolin H
-
pH 7.0, 22C
0.0000025 - 0.000022
methoxyacrylate stilbene
additional information
additional information
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00001593
3-[(2,4-diethylphenyl)amino]-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione
Sus scrofa
-
pH 7.4, 23C
0.001517
3-[(2,6-diethylphenyl)amino]-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione
Sus scrofa
-
pH 7.4, 23C
0.001
3-[(2-bromo-4-fluorophenyl)amino]-5-(6-bromopyridin-3-yl)-5-methyl-1,3-oxazolidine-2,4-dione
Sus scrofa
-
above, pH 7.4, 23C
0.00005998
3-[(2-bromo-4-fluorophenyl)amino]-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione
Sus scrofa
-
pH 7.4, 23C
0.001
3-[(4-bromophenyl)amino]-5-(6-bromopyridin-3-yl)-5-methyl-1,3-oxazolidine-2,4-dione
Sus scrofa
-
above, pH 7.4, 23C
0.00000944 - 0.001049
3-[(4-bromophenyl)amino]-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione
0.00001879
3-[(4-chlorophenyl)amino]-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione
Sus scrofa
-
pH 7.4, 23C
0.00005792
3-[(4-methoxyphenyl)amino]-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione
Sus scrofa
-
pH 7.4, 23C
0.00002404
3-[[5-methyl-2,4-dioxo-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidin-3-yl]amino]benzoic acid
Sus scrofa
-
pH 7.4, 23C
0.001
4-[[5-(6-bromopyridin-3-yl)-5-methyl-2,4-dioxo-1,3-oxazolidin-3-yl]amino]benzonitrile
Sus scrofa
-
above, pH 7.4, 23C
0.005312
4-[[5-methyl-2,4-dioxo-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidin-3-yl]amino]benzoic acid
Sus scrofa
-
pH 7.4, 23C
0.0002752
4-[[5-methyl-2,4-dioxo-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidin-3-yl]amino]benzonitrile
Sus scrofa
-
pH 7.4, 23C
0.001
5-(6-bromopyridin-3-yl)-3-[(2,4-diethylphenyl)amino]-5-methyl-1,3-oxazolidine-2,4-dione
0.00002376
5-methyl-3-[(4-methylphenyl)amino]-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione
Sus scrofa
-
pH 7.4, 23C
0.0000482 - 0.000142
5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-2,4-oxazolidinedione
0.00006326
5-methyl-5-(6-phenoxypyridin-3-yl)-3-[[4-(trifluoromethyl)phenyl]amino]-1,3-oxazolidine-2,4-dione
Sus scrofa
-
pH 7.4, 23C
0.00004
antimycin A
Roseobacter denitrificans
-
-
0.0004347 - 0.000527
azoxystrobin
0.000012
ilicicolin H
Saccharomyces cerevisiae
-
a Qn site inhibitor, a 5-(4-hydroxyphenyl)-alpha-pyridone with a decalin ring system, wild-type enzyme IC50: 12 nM
0.00004
Myxothiazol
Roseobacter denitrificans
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1.29
-
mutant with truncated cytochrome c1, membrane fraction
1.35
-
wild type, membrane fraction
160
-
-
308
-
mutant with truncated cytochrome c1, purified bc1 complex
469
-
wild type, purified bc1 complex
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5 - 8
additional information
-
below 10.0
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.4 - 9.2
-
-
6.5 - 8
-
activity increases with increasing pH
6.5 - 9
-
cytochrome bc1 complex
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
temperature dependent activity of complex III in preparations with phospholipids replaced by dimyristoylglycerophosphocholine
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
enzyme expression pattern during cell development
Manually annotated by BRENDA team
-
transgenic embryonic stem cell line with expression of the green fliuorescent protein under control of the alpha-myosin heavy chain promotor, enzyme expression pattern during cell development
Manually annotated by BRENDA team