Reference on EC 1.1.99.1 - choline dehydrogenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Osteras, M.; Boncompagni, E.; Vincent, N.; Poggi, M.C.; Le Rudulier, D.
Presence of a gene encoding choline sulfatase in Sinorhizobium meliloti bet operon: choline-O-sulfate is metabolized into glycine betaine
Proc. Natl. Acad. Sci. USA
95
11394-11399
1998
Escherichia coli
Pocard, J.A.; Vincent, N.; Boncompagni, E.; Tombras Smith, L.; Poggi, M.C.; Le Rudulier, D.
Molecular characterization of the bet genes encoding glycine betaine synthesis in Sinorhizobium meliloti 102F34
Microbiology
143
1369-1379
1997
Sinorhizobium meliloti 102F34, Sinorhizobium meliloti, Escherichia coli, Arthrobacter globiformis, Terminator, plant
Ameyama, M.; Shinagawa, E.; Matsushita, K.; Takimoto, K.; Nakashima, K.; Adachi, O.
Mammalian choline dehydrogenase is a quinoprotein
Agric. Biol. Chem.
49
3623-3626
1985
Canis lupus familiaris
-
Rendina, G.; Singer, T.P.
Studies on choline dehydrogenase
J. Biol. Chem.
234
1605-1610
1959
Rattus norvegicus
Barrett, M.C.; Dawson, A.P.
The reaction of choline dehydrogenase with some electron acceptors
Biochem. J.
151
677-683
1975
BRENDA: Rattus norvegicus
Textmining: Electron, Rattus, Naja naja, snake
Tsuge, H.; Nakano, Y.; Onishi, H.; Futamura, Y.; Ohashi, K.
A novel purification and some properties of rat liver mitochondrial choline dehydrogenase
Biochim. Biophys. Acta
614
274-284
1980
BRENDA: Rattus norvegicus
Textmining: Rattus, Electron
Nagasawa, T.; Mori, N.; Tani, Y.; Ogata, K.
Characterization of choline dehydrogenase from Pseudomonas aeruginosa A-16
Agric. Biol. Chem.
40
2077-2084
1976
Pseudomonas aeruginosa, Pseudomonas aeruginosa A-16
-
Nagasawa, T.; Kawabata, Y.; Tani, Y.; Ogata, K.
Choline dehydrogenase of Pseudomonas aeruginosa A-16
Agric. Biol. Chem.
39
1513-1514
1975
Pseudomonas aeruginosa, Pseudomonas aeruginosa A-16
-
Bater, A.J.; Venables, W.A.
The characterisation of inducible dehydrogenases specific for the oxidation of D-alanine, allohydroxy-D-proline, choline and sarcosine as peripheral membrane proteins in Pseudomonas aeruginosa
Biochim. Biophys. Acta
468
209-226
1977
Pseudomonas aeruginosa
Russell, R.; Scopes, R.K.
Use of hydrophobic chromatography for purification of the membrane-located choline dehydrogenase from a Pseudomonas strain
Bioseparation
4
279-284
1994
BRENDA: Pseudomonas aeruginosa, Pseudomonas aeruginosa C10
Textmining: Pseudomonas, Escherichia coli, Electron
Holmstrom, K.O.; Somersalo, S.; Mandal, A.; Palva, T.E.; Welin, B.
Improved tolerance to salinity and low temperature in transgenic tobacco producing glycine betaine
J. Exp. Bot.
51
177-185
2000
BRENDA: Nicotiana tabacum
Textmining: Bacteria, bacterium, Embryophyta, Escherichia coli, Transformation
Sugimoto, M.; Tanabe, M.; Hataya, M.; Enokibara, S.; Duine, J.A.; Kawai, F.
The first step in polyethylene glycol degradation by Sphingomonads proceeds via a flavoprotein alcohol dehydrogenase containing flavin adenine dinucleotide
J. Bacteriol.
183
6694-6698
2001
Pseudomonas, Pseudomonas oleovorans, Gluconobacter oxydans, Escherichia coli
Zeisel, S.H.; Wurtman, R.J.
Developmental changes in rat blood choline concentration
Biochem. J.
198
565-570
1981
Rattus, Metazoa
Gadda, G.; McAllister-Wilkins, E.E.
Cloning, expression, and purification of choline dehydrogenase from the moderate halophile Halomonas elongata
Appl. Environ. Microbiol.
69
2126-2132
2003
BRENDA: Halomonas elongata
Textmining: Escherichia coli, Electron
Huang, S.; Lin, Q.
Functional expression and processing of rat choline dehydrogenase precursor
Biochem. Biophys. Res. Commun.
309
344-350
2003
BRENDA: Rattus norvegicus (Q6UPE0)
Textmining: Rattus, Saccharomyces cerevisiae
Yilmaz, J.L.; Bulow, L.
Enhanced stress tolerance in Escherichia coli and Nicotiana tabacum expressing a betaine aldehyde dehydrogenase/choline dehydrogenase fusion protein
Biotechnol. Prog.
18
1176-1182
2002
Escherichia coli, Nicotiana tabacum
Hibino, T.; Waditee, R.; Araki, E.; Ishikawa, H.; Aoki, K.; Tanaka, Y.; Takabe, T.
Functional characterization of choline monooxygenase, an enzyme for betaine synthesis in plants
J. Biol. Chem.
277
41352-41360
2002
Escherichia coli, Spinacia oleracea, Spinacia oleracea (O04121)
Slow, S.; Garrow, T.A.
Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats
J. Nutr.
136
2279-2283
2006
BRENDA: Rattus norvegicus
Textmining: Rattus
Treberg, J.R.; Driedzic, W.R.
The accumulation and synthesis of betaine in winter skate (Leucoraja ocellata)
Comp. Biochem. Physiol. A
147
475-483
2007
BRENDA: Leucoraja ocellata
Textmining: vertebrata, Chondrichthyes, Doryteuthis pealeii
Konstantinova, S.V.; Tell, G.S.; Vollset, S.E.; Nygard, O.; Bleie, O.; Ueland, P.M.
Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women
J. Nutr.
138
914-920
2008
Homo sapiens (Q8NE62), Homo sapiens
Barrett, A.R.; Kang, Y.; Inamasu, K.S.; Son, M.S.; Vukovich, J.M.; Hoang, T.T.
Genetic tools for allelic replacement in Burkholderia species
Appl. Environ. Microbiol.
74
4498-4508
2008
Burkholderia thailandensis
Clow, K.A.; Treberg, J.R.; Brosnan, M.E.; Brosnan, J.T.
Elevated tissue betaine contents in developing rats are due to dietary betaine, not to synthesis
J. Nutr.
138
1641-1646
2008
BRENDA: Rattus norvegicus
Textmining: Mammalia
Duan, X.; Song, Y.; Yang, A.; Zhang, J.
The transgene pyramiding tobacco with betaine synthesis and heterologous expression of AtNHX1 is more tolerant to salt stress than either of the tobacco lines with betaine synthesis or AtNHX1
Physiol. Plant.
135
281-295
2009
BRENDA: Escherichia coli
Textmining: Escherichia, Arabidopsis
Johnson, A.R.; Craciunescu, C.N.; Guo, Z.; Teng, Y.W.; Thresher, R.J.; Blusztajn, J.K.; Zeisel, S.H.
Deletion of murine choline dehydrogenase results in diminished sperm motility
FASEB J.
24
2752-2761
2010
BRENDA: Mus musculus
Textmining: Homo sapiens, Mus sp., Alopias vulpinus, Metazoa, Electron
Rajan, L.; Joseph, T.; Thampuran, N.; James, R.
Functional characterization and sequence analysis of choline dehydrogenase from Escherichia coli
Genet. Eng. Biotechnol. J.
2010
0000
2010
Escherichia coli (A7LLT8), Escherichia coli TCJAR023 (A7LLT8)
-
Johnson, A.R.; Lao, S.; Wang, T.; Galanko, J.A.; Zeisel, S.H.
Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function
PLoS ONE
7
e36047
2012
BRENDA: Homo sapiens
Textmining: Mus sp.
AnbuRajan, L.; Sindhuja, S.; Rajalakshmi, Y.; Umashankar, V.
Cloning of choline dehydrogenase from Escherichia coli: its polynucleotide and polypeptide analysis
Res. J. Microbiol.
6
297-303
2011
Escherichia coli (C1KFX7)
-
Salvi, F.; Gadda, G.
Human choline dehydrogenase medical promises and biochemical challenges
Arch. Biochem. Biophys.
537
243-252
2013
Rattus norvegicus (Q6UPE0), Homo sapiens (Q8NE62), Homo sapiens
Park, S.; Choi, S.G.; Yoo, S.M.; Son, J.H.; Jung, Y.K.
Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy
Autophagy
10
1906-1920
2014
Mus musculus (Q8BJ64), Homo sapiens (Q8NE62)
McClatchie, T.; Meredith, M.; Ouedraogo, M.O.; Slow, S.; Lever, M.; Mann, M.R.W.; Zeisel, S.H.; Trasler, J.M.; Baltz, J.M.
Betaine is accumulated via transient choline dehydrogenase activation during mouse oocyte meiotic maturation
J. Biol. Chem.
292
13784-13794
2017
Mus musculus (Q8BJ64), Mus musculus
Toonen, LJA; Overzier, M; Evers, MM; Leon, LG; van der Zeeuw, SAJ; Mei, H; Kielbasa, SM; Goeman, JJ; Hettne, KM; Magnusson, OT; Poirel, M; Seyer, A; 't Hoen, PAC; van Roon-Mom, WMC
Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model.
Mol Neurodegener
13
31
2018
Mus musculus
Qiu, ZH; Lin, QS
Spectra properties of rat liver mitochondrial choline dehydrogenase.
Sci China B
33
955-63
1990
Rattus
Barlow, P; Marchbanks, RM
The effects of inhibiting choline dehydrogenase on choline metabolism in mice.
Biochem Pharmacol
34
3117-22
1985
Mus sp.
Kramar, R; Kremser, K; Raab, R
Enhancement of choline dehydrogenase activity in rat liver mitochondria by clofibrate feeding.
Hoppe Seylers Z Physiol Chem
365
1207-10
1984
Rattus
Miller, B; Schmid, H; Chen, TJ; Schmolke, M; Guder, WG
Determination of choline dehydrogenase activity along the rat nephron.
Biol Chem Hoppe Seyler
377
129-37
1996
Rattus
Perrino, LA; Pierce, SK
Choline dehydrogenase kinetics contribute to glycine betaine regulation differences in chesapeake bay and atlantic oysters.
J Exp Zool
286
250-61
2000
Ostreidae
GLOGNER, P; GOESSNER, W
[Histochemical demonstration of choline dehydrogenase in animal tissue.]
Z Zellforch Microsk Anat Histochem
2
435-41
1962
animal
WOHLRAB, F
[HISTOCHEMICAL STUDIES ON THE DEMONSTRATION OF CHOLINE DEHYDROGENASE IN MAMMALS.]
Z Zellforch Microsk Anat Histochem
34
286-97
1963
Mammalia
CASTOLDI, GL; MERKER, H
[DEMONSTRATION AND SIGNIFICANCE OF HISTOCHEMICALLY DEMONSTRABLE CHOLINE DEHYDROGENASE IN HUMAN BLOOD AND BONE MARROW CELLS.]
Klin Wochenschr
43
368-75
1965
Homo sapiens
Lazaros, L; Xita, N; Hatzi, E; Kaponis, A; Makrydimas, G; Takenaka, A; Sofikitis, N; Stefos, T; Zikopoulos, K; Georgiou, I
Phosphatidylethanolamine N-methyltransferase and choline dehydrogenase gene polymorphisms are associated with human sperm concentration.
Asian J Androl
2012
Homo sapiens
McClatchie, T; Meredith, M; Oudraogo, MO; Slow, S; Lever, M; Mann, MRW; Zeisel, SH; Trasler, JM; Baltz, JM
Correction: Betaine is accumulated via transient choline dehydrogenase activation during mouse oocyte meiotic maturation.
J Biol Chem
295
10868
2020
Mus musculus
Breisch, J; Bendel, M; Averhoff, B
The choline dehydrogenase BetA of Acinetobacter baumannii: a flavoprotein responsible for osmotic stress protection.
Environ Microbiol
2021
Acinetobacter baumannii
Ash, JA; Jiang, X; Malysheva, OV; Fiorenza, CG; Bisogni, AJ; Levitsky, DA; Strawderman, MS; Caudill, MA; Stover, PJ; Strupp, BJ
Dietary and genetic manipulations of folate metabolism differentially affect neocortical functions in mice.
Neurotoxicol Teratol
38
79-91
0
Mus sp., Homo sapiens
Lidbury, I; Kimberley, G; Scanlan, DJ; Murrell, JC; Chen, Y
Comparative genomics and mutagenesis analyses of choline metabolism in the marine Roseobacter clade.
Environ Microbiol
17
5048-62
2015
Ruegeria pomeroyi, bacterium, Roseobacter, Bacteria, eukaryota
Zhang, J; Blusztajn, JK; Zeisel, SH
Measurement of the formation of betaine aldehyde and betaine in rat liver mitochondria by a high pressure liquid chromatography-radioenzymatic assay.
Biochim Biophys Acta
1117
333-9
1992
Rattus, Electron
Lamark, T; Kaasen, I; Eshoo, MW; Falkenberg, P; McDougall, J; Strøm, AR
DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli.
Mol Microbiol
5
1049-64
1991
Escherichia coli
Styrvold, OB; Falkenberg, P; Landfald, B; Eshoo, MW; Bjørnsen, T; Strøm, AR
Selection, mapping, and characterization of osmoregulatory mutants of Escherichia coli blocked in the choline-glycine betaine pathway.
J Bacteriol
165
856-63
1986
Escherichia coli
Treberg, JR; Speers-Roesch, B; Piermarini, PM; Ip, YK; Ballantyne, JS; Driedzic, WR
The accumulation of methylamine counteracting solutes in elasmobranchs with differing levels of urea: a comparison of marine and freshwater species.
J Exp Biol
209
860-70
2006
Elasmobranchii
Scholz, A; Stahl, J; de Berardinis, V; Mller, V; Averhoff, B
Osmotic stress response in Acinetobacter baylyi: identification of a glycine-betaine biosynthesis pathway and regulation of osmoadaptive choline uptake and glycine-betaine synthesis through a choline-responsive BetI repressor.
Environ Microbiol Rep
8
316-22
2016
Acinetobacter baylyi, bacterium
Mao, Y; Chen, N; Cao, M; Chen, R; Guan, X; Wang, D
Functional Characterization and Evolutionary Analysis of Glycine-Betaine Biosynthesis Pathway in Red Seaweed Pyropia yezoensis.
Mar Drugs
17
2019
Pyropia
Tsuge, H; Sato, N; Koshiba, T; Ohashi, Y; Narita, Y; Takahashi, K; Ohashi, K
Change of choline metabolism in rat liver on chronic ethionine-feeding.
Biochim Biophys Acta
881
141-7
1986
Rattus
Thörig, GE; Heinstra, PW; de Ruiter, BL; Scharloo, W
The effects of recessive lethal Notch mutations of Drosophila melanogaster on flavoprotein enzyme activities whose inhibitions cause Notch-like phenocopies.
Biochem Genet
25
7-25
1987
Diptera, Drosophila melanogaster
Saito, Y; Ishii, Y; Hayashi, H; Yoshikawa, K; Noguchi, Y; Yoshida, S; Soeda, S; Yoshida, M
Direct fermentation of 2-keto-L-gulonic acid in recombinant Gluconobacter oxydans.
Biotechnol Bioeng
58
309-15
0
Escherichia coli
Boncompagni, E; Osteras, M; Poggi, MC; le Rudulier D,
Occurrence of choline and glycine betaine uptake and metabolism in the family rhizobiaceae and their roles in osmoprotection
Appl Environ Microbiol
65
2072-7
1999
Mesorhizobium huakuii
Quan, R; Shang, M; Zhang, H; Zhao, Y; Zhang, J
Engineering of enhanced glycine betaine synthesis improves drought tolerance in maize.
Plant Biotechnol J
2
477-86
2004
Zea mays, Escherichia coli
Friesen, RW; Novak, EM; Hasman, D; Innis, SM
Relationship of dimethylglycine, choline, and betaine with oxoproline in plasma of pregnant women and their newborn infants.
J Nutr
137
2641-6
2007
Homo sapiens, Indicator
Wei, A; He, C; Li, B; Li, N; Zhang, J
The pyramid of transgenes TsVP and BetA effectively enhances the drought tolerance of maize plants.
Plant Biotechnol J
2010
Zea mays, Escherichia, Thellungiella
Andringa, KK; Udoh, US; Landar, A; Bailey, SM
Proteomic analysis of 4-hydroxynonenal (4-HNE) modified proteins in liver mitochondria from chronic ethanol-fed rats.
Redox Biol
2C
1038-1047
2014
Electron
Selvaratnam, C; Thevarajoo, S; Goh, KM; Chan, KG; Chong, CS
Genomic analyses of five Roseivirga species: Insights into marine adaptation.
Mar Genomics
2018
Roseivirga
King, JH; Kwan, STC; Bae, S; Klatt, KC; Yan, J; Malysheva, OV; Jiang, X; Roberson, MS; Caudill, MA
Maternal choline supplementation alters vitamin B-12 status in human and murine pregnancy.
J Nutr Biochem
72
108210
2019
Homo sapiens
Chirita-Emandi, A; Serban, CL; Paul, C; Andreescu, N; Velea, I; Mihailescu, A; Serafim, V; Tiugan, DA; Tutac, P; Zimbru, C; Puiu, M; Niculescu, MD
CHDH-PNPLA3 Gene-Gene Interactions Predict Insulin Resistance in Children with Obesity.
Diabetes Metab Syndr Obes
13
4483-4494
2020
Homo sapiens
Quan R;Shang M;Zhang H;Zhao Y;Zhang J
Improved chilling tolerance by transformation with betA gene for the enhancement of glycinebetaine synthesis in maize.
Plant science : an international journal of experimental plant biology
166
141-149
2004
Zea mays, Transformation, Escherichia coli
Kumar, J; Garg, G; Karthikeyan, G; Sengupta, S
Cystathionine beta-synthase 844Ins68 polymorphism is not associated with the levels of homocysteine and cysteine in an Indian population.
Biomarkers
15
283-7
2010
Homo sapiens
Agarwal, DP; Schwenkenbecher, S; Srivastava, LM; Goedde, HW
[A spectrophotometric method for the determination of serum cholinesterase variants with succinyl choline as substrate (author's transl)]
Z Klin Chem Klin Biochem
13
133-5
1975
Rattus
Grossman, EB; Hebert, SC
Renal inner medullary choline dehydrogenase activity: characterization and modulation.
Am J Physiol
256
F107-12
1989
Rattus
Allen, SC
The effect of longterm alcohol exposure on liver choline dehydrogenase activity.
Med J Zambia
15
34-7
0
Rattus, Mammalia
Tan, QH; Penkovsky, L; Zedeck, MS
Histochemical findings suggesting that methylazoxymethanol, a liver and kidney carcinogen, is a substrate for hepatic and renal choline dehydrogenase.
Carcinogenesis
2
1135-9
1981
Electron, Rattus
Wang, Z; Dahiya, S; Provencher, H; Muir, B; Carney, E; Coser, K; Shioda, T; Ma, XJ; Sgroi, DC
The Prognostic Biomarkers HOXB13, IL17BR, and CHDH Are Regulated by Estrogen in Breast Cancer.
Clin Cancer Res
13
6327-6334
2007
Homo sapiens
Mostowska, A; Biedziak, B; Dunin-Wilczynska, I; Komorowska, A; Jagodzinski, PP
Polymorphisms in CHDH gene and the risk of tooth agenesis.
Birth Defects Res A Clin Mol Teratol
91
169-76
2011
Homo sapiens
Chang, H; Li, L; Peng, T; Grigoroiu-Serbanescu, M; Bergen, SE; Landn, M; Hultman, CM; Forstner, AJ; Strohmaier, J; Hecker, J; Schulze, TG; Mller-Myhsok, B; Reif, A; Mitchell, PB; Martin, NG; Cichon, S; Nthen, MM; Jamain, S; Leboyer, M; Bellivier, F; Etain, B; Kahn, JP; Henry, C; Rietschel, M; , ; , ; Xiao, X; Li, M
Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1.
Mol Neurobiol
2016
Homo sapiens
Mostowska, A; Hozyasz, KK; Biedziak, B; Misiak, J; Jagodzinski, PP
Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts.
Eur J Oral Sci
118
325-32
2010
Homo sapiens
Szczepa?ska, M; Mostowska, A; Wirstlein, P; Lianeri, M; Marianowski, P; Skrzypczak, J; Jagodzi?ski, PP
Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility.
Eur J Obstet Gynecol Reprod Biol
2011
Homo sapiens
Yao, RQ; Ren, C; Xia, ZF; Yao, YM
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Autophagy
1-17
2020
Felis catus, Ariadne
Thompson, JA; Reitz, RC
A possible mechanism for the increased oxidation of choline after chronic ethanol ingestion.
Biochim Biophys Acta
545
381-97
1979
Rattus
Cavener, DR
GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities.
J Mol Biol
223
811-4
1992
Escherichia coli, Aspergillus niger, Drosophila melanogaster, Ogataea angusta
Ma, XJ; Hilsenbeck, SG; Wang, W; Ding, L; Sgroi, DC; Bender, RA; Osborne, CK; Allred, DC; Erlander, MG
The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer.
J Clin Oncol
24
4611-9
2006
Homo sapiens
Du, YF; Luo, WP; Lin, FY; Lian, ZQ; Mo, XF; Yan, B; Xu, M; Huang, WQ; Huang, J; Zhang, CX
Dietary choline and betaine intake, choline-metabolising genetic polymorphisms and breast cancer risk: a case-control study in China.
Br J Nutr
116
961-8
2016
Homo sapiens
Drews, K; R?ycka, A; Barlik, M; Klejewski, A; Kurzawi?ska, G; Wolski, H; Majchrzycki, M; Gryszczy?ska, A; Kami?ski, A; Seremak-Mrozikiewicz, A
Polymorphic variants of genes involved in choline pathway and the risk of intrauterine fetal death.
Ginekol Pol
88
205-211
2017
Homo sapiens
Ohnishi, T; Balan, S; Toyoshima, M; Maekawa, M; Ohba, H; Watanabe, A; Iwayama, Y; Fujita, Y; Tan, Y; Hisano, Y; Shimamoto-Mitsuyama, C; Nozaki, Y; Esaki, K; Nagaoka, A; Matsumoto, J; Hino, M; Mataga, N; Hayashi-Takagi, A; Hashimoto, K; Kunii, Y; Kakita, A; Yabe, H; Yoshikawa, T
Investigation of betaine as a novel psychotherapeutic for schizophrenia.
EBioMedicine
45
432-446
2019
Homo sapiens, Mus sp.
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