Reference on EC 1.1.1.86 - ketol-acid reductoisomerase (NADP+)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ryan, E.D.; Kohlhaw, G.B.
Subcellular localization of isoleucine-valine biosynthetic enzymes in yeast
J. Bacteriol.
120
631-637
1974
Saccharomyces cerevisiae
Xing, R.; Whitman, W.B.
Characterization of enzymes of the branched-chain amino acid biosynthetic pathway in Methanococcus spp
J. Bacteriol.
173
2086-2092
1991
Methanococcus voltae, Methanococcus maripaludis, Methanococcus aeolicus
Shimizu, S.; Kataoka, M.; Ching-Ming Chung, M.; Yamada, H.
Ketopantoic acid reductase of Pseudomonas maltophilia 845. Purification, characterization, and role in pantothenate biosynthesis
J. Biol. Chem.
263
12077-12084
1988
Stenotrophomonas maltophilia
Grolle, S.; Bringer-Meyer, S.; Sahm, H.
Isolation of the dxr gene of Zymomonas mobilis and characterization of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase
FEMS Microbiol. Lett.
191
131-137
2000
Zymomonas mobilis
Lange, B.M.; Croteau, R.
Isoprenoid biosynthesis via a mevalonate-independent pathway in plants: Cloning and heterologous expression of 1-deoxy-D-xylulose-5-phosphate reductoisomerase from peppermint
Arch. Biochem. Biophys.
365
170-174
1999
plant
Suresh, S.; Turley, S.; Opperdoes, F.R.; Michels, P.A.M.; Hol, W.G.J.
A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana
Structure
8
541-552
2000
plant
Cane, D.E.; Chow, C.; Lillo, A.; Kang, I.
Molecular cloning, expression and characterization of the first three genes in the mevalonate-independent isoprenoid pathway in Streptomyces coelicolor
Bioorg. Med. Chem.
9
1467-1477
2001
Escherichia coli
Arfin, S.M.; Umbarger, H.E.
Purification and properties of the acetohydroxy acid isomeroreductase of Salmonella typhimurium
J. Biol. Chem.
244
1118-1127
1969
Salmonella enterica subsp. enterica serovar Typhimurium
Satyanarayana, T.; Radhakrishnan, A.N.
Biosynthesis of valine and isoleucine in plants. 3. Reductoisomerase of Phaseolus radiatus
Biochim. Biophys. Acta
110
380-388
1965
BRENDA: Vigna radiata var. radiata
Textmining: Phaseolus
Kiritani, K.; Narise, S.; Wagner, R.P.
The reductoisomerase of Neurospora crassa
J. Biol. Chem.
241
2047-2051
1966
Neurospora crassa
-
Shematek, E.M.; Arfin, S.M.; Diven, W.F.
A kinetic study of alpha-acetohydroxy acid isomeroreductase from Salmonella typhimurium
Arch. Biochem. Biophys.
158
132-138
1973
Salmonella enterica subsp. enterica serovar Typhimurium
Hofler, J.G.; Decedue, C.J.; Luginbuhl, G.H.; Reynolds, J.A.; Burns, R.O.
The subunit structure of alpha-acetohydroxyacid isomeroreductase from Salmonella typhimurium
J. Biol. Chem.
250
877-882
1975
Salmonella enterica subsp. enterica serovar Typhimurium
Chunduru, S.K.; Mrachko, G.T.; Calvo, K.C.
Mechanism of ketol acid reductoisomerase--steady-state analysis and metal ion requirement
Biochemistry
28
486-493
1989
Escherichia coli
Dumas, R.; Joyard, J.; Douce, R.
Purification and characterization of acetohydroxyacid reductoisomerase from spinach chloroplasts
Biochem. J.
262
971-976
1989
Spinacia oleracea
Aulabaugh, A.; Schloss, J.V.
Oxalyl hydroxamates as reaction-intermediate analogues for ketol-acid reductoisomerase
Biochemistry
29
2824-2830
1990
Escherichia coli
Mrachko, G.T.; Chunduru, S.K.; Calvo, K.C.
The pH dependence of the kinetic parameters of ketol acid reductoisomerase indicates a proton shuttle mechanism for alkyl migration
Arch. Biochem. Biophys.
294
446-453
1992
Escherichia coli
Dumas, R.; Job, D.; Ortholand, J.Y.; Emeric, G.; Greiner, A.; Douce, R.
Isolation and kinetic properties of acetohydroxy acid isomeroreductase from spinach (Spinacia oleracea) chloroplasts overexpressed in Escherichia coli
Biochem. J.
288
865-874
1992
Spinacia oleracea
-
Durner, J.; Knoerzer, O.C.; Boeger, P.
Ketol-acid reductoisomerase from barley (Hordeum vulgare). Purification, properties, and specific inhibition
Plant Physiol.
103
903-910
1993
Hordeum vulgare
Dumas, R.; Cornillon-Bertrand, C.; Guigue-Talet, P.; Genix, P.; Douce, R.; Job, D.
Interactions of plant acetohydroxy acid isomeroreductase with reaction intermediate analogues: correlation of the slow, competitive, inhibition kinetics of enzyme activity and herbicidal effects
Biochem. J.
301
813-820
1994
Ipomoea purpurea, Solanum nigrum, Spinacia oleracea
-
Biou, V.; Dumas, R.; Cohen-Addad, C.; Douce, R.; Job, D.; Pebay-Peyroula, E.
The crystal structure of plant acetohydroxy acid isomeroreductase complexed with NADPH, two magnesium ions and a herbicidal transition state analog determined at 1.65 A resolution
EMBO J.
16
3405-3415
1997
BRENDA: Spinacia oleracea
Textmining: plant, Metazoa
Rane, M.J.; Calvo, K.C.
Reversal of the nucleotide specificity of ketol acid reductoisomerase by site-directed mutagenesis identifies the NADPH binding site
Arch. Biochem. Biophys.
338
83-89
1997
Escherichia coli
Dumas, R.; Biou, V.; Douce, R.
Purification and characterization of a fusion protein of plant acetohydroxy acid synthase and acetohydroxy acid isomeroreductase
FEBS Lett.
408
156-160
1997
BRENDA: Spinacia oleracea
Textmining: Arabidopsis thaliana, Escherichia coli, plant
Wessel, P.M.; Biou, V.; Douce, R.; Dumas, R.
A loop deletion in the plant acetohydroxy acid isomeroreductase homodimer generates an active monomer with reduced stability and altered magnesium affinity
Biochemistry
37
12753-12760
1998
BRENDA: Spinacia oleracea
Textmining: plant, Escherichia coli
Thomazeau, K.; Dumas, R.; Halgand, F.; Forest, E.; Douce, R.; Biou, V.
Structure of spinach acetohydroxyacid isomeroreductase complexed with its reaction product dihydroxymethylvalerate, manganese and (phospho)-ADP-ribose
Acta Crystallogr. Sect. D
56
389-397
2000
Spinacia oleracea
-
Dumas, R.; Biou, V.; Halgand, F.; Douce, R.; Duggleby, R.G.
Enzymology, structure, and dynamics of acetohydroxy acid isomeroreductase
Acc. Chem. Res.
34
399-408
2001
Escherichia coli, Triticum aestivum, Spinacia oleracea (Q01292)
Eom, S.J.; Ahn, H.J.; Yoon, H.J.; Lee, B.I.; Bae, S.H.; Baek, S.H.; Suh, S.W.
Crystallization and preliminary X-ray crystallographic analysis of acetohydroxy acid isomeroreductase from Pseudomonas aeruginosa
Acta Crystallogr. Sect. D
58
2145-2146
2002
BRENDA: Pseudomonas aeruginosa
Textmining: Escherichia coli
McCourt, J.A.; Tyagi, R.; Guddat, L.W.; Biou, V.; Duggleby, R.G.
Facile crystallization of Escherichia coli ketol-acid reductoisomerase
Acta Crystallogr. Sect. D
60
1432-1434
2004
Escherichia coli
Argyrou, A.; Blanchard, J.S.
Kinetic and chemical mechanism of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate isomeroreductase
Biochemistry
43
4375-4384
2004
Mycobacterium tuberculosis, Escherichia coli
Tyagi, R.; Lee, Y.T.; Guddat, L.W.; Duggleby, R.G.
Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site
FEBS J.
272
593-602
2005
Escherichia coli
Leyval, D.; Uy, D.; Delaunay, S.; Goergen, J.L.; Engasser, J.M.
Characterisation of the enzyme activities involved in the valine biosynthetic pathway in a valine-producing strain of Corynebacterium glutamicum
J. Biotechnol.
104
241-252
2003
Corynebacterium glutamicum
Merkamm, M.; Chassagnole, C.; Lindley, N.D.; Guyonvarch, A.
Ketopantoate reductase activity is only encoded by ilvC in Corynebacterium glutamicum
J. Biotechnol.
104
253-260
2003
Corynebacterium glutamicum, Escherichia coli
Ahn, H.J.; Eom, S.J.; Yoon, H.J.; Lee, B.I.; Cho, H.; Suh, S.W.
Crystal structure of class I acetohydroxy acid isomeroreductase from Pseudomonas aeruginosa
J. Mol. Biol.
328
505-515
2003
BRENDA: Pseudomonas aeruginosa
Textmining: Spinacia oleracea
Elisakova, V.; Patek, M.; Holatko, J.; Nesvera, J.; Leyval, D.; Goergen, J.L.; Delaunay, S.
Feedback-resistant acetohydroxy acid synthase increases valine production in Corynebacterium glutamicum
Appl. Environ. Microbiol.
71
207-213
2005
BRENDA: Corynebacterium glutamicum
Textmining: Escherichia
Grenville-Briggs, L.J.; Avrova, A.O.; Bruce, C.R.; Williams, A.; Whisson, S.C.; Birch, P.R.; van West, P.
Elevated amino acid biosynthesis in Phytophthora infestans during appressorium formation and potato infection
Fungal Genet. Biol.
42
244-256
2005
Phytophthora infestans
Zabalza, A.; Gonzalez, E.M.; Arrese-Igor, C.; Royuela, M.
Fermentative metabolism is induced by inhibiting different enzymes of the branched-chain amino acid biosynthesis pathway in pea plants
J. Agric. Food Chem.
53
7486-7493
2005
Pisum sativum
Wang, B.L.; Duggleby, R.G.; Li, Z.M.; Wang, J.G.; Li, Y.H.; Wang, S.H.; Song, H.B.
Synthesis, crystal structure and herbicidal activity of mimics of intermediates of the KARI reaction
Pest Manag. Sci.
61
407-412
2005
Amaranthus retroflexus, Brassica rapa subsp. oleifera, Echinochloa crus-galli, Medicago sativa, Digitaria adscendens
Lee, Y.; Ta, H.T.; Duggleby, R.G.
Cyclopropane-1,1-dicarboxylate is a slow-, tight-binding inhibitor of rice ketol-acid reductoisomerase
Plant Sci.
168
1035-1040
2005
Oryza sativa (Q65XK0)
Tyagi, R.; Duquerroy, S.; Navaza, J.; Guddat, L.W.; Duggleby, R.G.
The crystal structure of a bacterial class II ketol-acid reductoisomerase: domain conservation and evolution
Protein Sci.
14
3089-3100
2005
BRENDA: Escherichia coli
Textmining: Bacteria, Pseudomonas aeruginosa, Spinacia oleracea, Fungi
Fernandes, R.P.; Proteau, P.J.
Kinetic characterization of Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase mutants
Biochim. Biophys. Acta
1764
223-229
2006
Synechocystis sp.
Woo, Y.H.; Fernandes, R.P.; Proteau, P.J.
Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Bioorg. Med. Chem.
14
2375-2385
2006
Synechocystis sp.
Kim, S.; Kuzuyama, T.; Chang, Y.; Song, K.; Kim, S.
Identification of class 2 1-deoxy-D-xylulose 5-phosphate synthase and 1-deoxy-D-xylulose 5-phosphate reductoisomerase genes from Ginkgo biloba and their transcription in embryo culture with respect to ginkgolide biosynthesis
Planta Med.
72
234-240
2006
Ginkgo biloba, Ginkgo biloba (Q5J7B3), Ginkgo biloba (Q5J7B4)
Tahar, R.; Basco, L.K.
Molecular epidemiology of malaria in Cameroon. XXV. In vitro activity of fosmidomycin and its derivatives against fresh clinical isolates of Plasmodium falciparum and sequence analysis of 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Am. J. Trop. Med. Hyg.
77
214-220
2007
Plasmodium, Plasmodium falciparum, Plasmodium falciparum (O96693)
Wong, U.; Cox, R.J.
The chemical mechanism of D-1-deoxyxylulose-5-phosphate reductoisomerase from Escherichia coli
Angew. Chem. Int. Ed. Engl.
46
4926-4929
2007
Escherichia coli
Fitzgerald-Hughes, D.H.; Coleman, D.C.; OConnell, B.C.
Differentially expressed proteins in derivatives of Candida albicans displaying a stable histatin 3-resistant phenotype
Antimicrob. Agents Chemother.
51
2793-2800
2007
Candida albicans
Omura, F.
Targeting of mitochondrial Saccharomyces cerevisiae Ilv5p to the cytosol and its effect on vicinal diketone formation in brewing
Appl. Microbiol. Biotechnol.
78
503-513
2008
Saccharomyces cerevisiae
Liu, X.H.; Chen, P.Q.; Wang, B.L.; Li, Y.H.; Wang, S.H.; Li, Z.M.
Synthesis, bioactivity, theoretical and molecular docking study of 1-cyano-N-substituted-cyclopropanecarboxamide as ketol-acid reductoisomerase inhibitor
Bioorg. Med. Chem. Lett.
17
3784-3788
2007
BRENDA: Spinacia oleracea
Textmining: Oryza sativa
Wang, B.; Li, Z.; Li, Y.; Wang, S.
Syntheses and biological activities of ethyl N-hydroxy-N-(substituted)phenyloxamates as KARI inhibitors
Chem. Res. Chin. Univ.
23
280-283
2007
Oryza sativa
-
Wada, M.; Hijikata, N.; Aoki, R.; Takesue, N.; Yokota, A.
Enhanced valine production in Corynebacterium glutamicum with defective H+-ATPase and C-terminal truncated acetohydroxyacid synthase
Biosci. Biotechnol. Biochem.
72
2959-2965
2008
Corynebacterium glutamicum, Transformation
Wang, B.; Li, Y.; Wang, J.; Ma, Y.; Li, Z.
Molecular design, synthesis and biological activities of amidines as new ketol-acid reductoisomerase inhibitors
Chin. Chem. Lett.
19
651-654
2008
Escherichia coli, Oryza sativa, Spinacia oleracea
-
Wang, B.; Ma, Y.; Li, Y.; Wang, S.; Li, Z.
The design, synthesis of amide KARI inhibitors and their biological activities
Front. Chem. Chin.
4
186-190
2009
Spinacia oleracea
-
Liu, X.H.; Zhang, C.Y.; Guo, W.C.; Li, Y.H.; Chen, P.Q.; Wang, T.; Dong, W.L.; Wang, B.L.; Sun, H.W.; Li, Z.M.
Synthesis, bioactivity and SAR study of N-(5-substituted-1,3,4-thiadiazol-2-yl)-N-cyclopropylformyl-thioureas as ketol-acid reductoisomerase inhibitors
J. Enzyme Inhib. Med. Chem.
24
545-552
2009
BRENDA: Oryza sativa
Textmining: Spinacia oleracea
Leung, E.W.; Guddat, L.W.
Conformational changes in a plant ketol-acid reductoisomerase upon Mg2+ and NADPH binding as revealed by two crystal structures
J. Mol. Biol.
389
167-182
2009
BRENDA: Oryza sativa (Q65XK0), Oryza sativa
Textmining: plant, Spinacia oleracea
Liu, X.H.; Chen, P.Q.; Wang, B.L.; Dong, W.L.; Li, Y.H.; Xie, X.Q.; Li, Z.M.
High throughput receptor-based virtual screening under ZINC database, synthesis, and biological evaluation of ketol-acid reductoisomerase inhibitors
Chem. Biol. Drug Des.
75
228-232
2010
Oryza sativa
Wang, B.; Ma, Y.; Li, Y.; Wang, S.; Li, Z.
The design, synthesis of amide KARI inhibitors and their biological activities
Front. Chem.
4
186-190
2009
Brassica rapa subsp. oleifera, Echinochloa crus-galli, Oryza sativa
-
Krause, F.S.; Blombach, B.; Eikmanns, B.J.
Metabolic engineering of Corynebacterium glutamicum for 2-ketoisovalerate production
Appl. Environ. Microbiol.
76
8053-8061
2010
Corynebacterium glutamicum, Corynebacterium glutamicum (Q8NNF6), Corynebacterium glutamicum (P42463)
Li, S.; Wen, J.; Jia, X.
Engineering Bacillus subtilis for isobutanol production by heterologous Ehrlich pathway construction and the biosynthetic 2-ketoisovalerate precursor pathway overexpression
Appl. Microbiol. Biotechnol.
91
577-589
2011
Bacillus subtilis, Corynebacterium glutamicum, Corynebacterium glutamicum (Q8NQZ9)
Denina, I.; Paegle, L.; Prouza, M.; Holatko, J.; Patek, M.; Nesvera, J.; Ruklisha, M.
Factors enhancing L-valine production by the growth-limited L-isoleucine auxotrophic strain Corynebacterium glutamicum DeltailvA DeltapanB ilvNM13 (pECKAilvBNC)
J. Ind. Microbiol. Biotechnol.
37
689-699
2010
Corynebacterium glutamicum, Corynebacterium glutamicum (Q8NQZ9)
Wong, S.H.; Lonhienne, T.G.; Winzor, D.J.; Schenk, G.; Guddat, L.W.
Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle
J. Mol. Biol.
424
168-179
2012
BRENDA: Escherichia coli (P05793), Escherichia coli
Textmining: Bacteria, Fungi, Metazoa, plant
Cahn, J.K.; Brinkmann-Chen, S.; Spatzal, T.; Wiig, J.A.; Buller, A.R.; Einsle, O.; Hu, Y.; Ribbe, M.W.; Arnold, F.H.
Cofactor specificity motifs and the induced fit mechanism in Class I ketol-acid reductoisomerases
Biochem. J.
468
475-484
2015
BRENDA: Azotobacter vinelandii (C1DFH7), Alicyclobacillus acidocaldarius subsp. acidocaldarius (C8WR67), Ignisphaera aggregans (E0SRA9), uncultured archaeon (Q64BR7), Ignisphaera aggregans DSM 17230 (E0SRA9), Azotobacter vinelandii ATCC BAA-1303 (C1DFH7)
Textmining: Escherichia coli, Spinacia oleracea, Oryza sativa
Blombach, B.; Riester, T.; Wieschalka, S.; Ziert, C.; Youn, J.; Wendisch, V.; Eikmanns, B.
Corynebacterium glutamicum tailored for efficient isobutanol production
Appl. Environ. Microbiol.
77
3300-3310
2011
Corynebacterium glutamicum
Oh, B.R.; Heo, S.Y.; Lee, S.M.; Hong, W.K.; Park, J.M.; Jung, Y.R.; Kim, D.H.; Sohn, J.H.; Seo, J.W.; Kim, C.H.
Production of 2-butanol from crude glycerol by a genetically-engineered Klebsiella pneumoniae strain
Biotechnol. Lett.
36
57-62
2014
Klebsiella pneumoniae subsp. pneumoniae (A6TGG1), Klebsiella pneumoniae subsp. pneumoniae ATCC 700721 (A6TGG1)
Reisse, S.; Garbe, D.; Brueck, T.
Identification and optimization of a novel thermo- and solvent stable ketol-acid reductoisomerase for cell free isobutanol biosynthesis
Biochimie
108
76-84
2015
BRENDA: Meiothermus ruber (D3PT81), Meiothermus ruber, Meiothermus ruber DSM 1279 (D3PT81)
Textmining: bacterium
Tadrowski, S.; Pedroso, M.M.; Sieber, V.; Larrabee, J.A.; Guddat, L.W.; Schenk, G.
Metal ions play an essential catalytic role in the mechanism of ketol-acid reductoisomerase
Chemistry
22
7427-7436
2016
Escherichia coli, Oryza sativa
Lv, Y.; Kandale, A.; Wun, S.J.; McGeary, R.P.; Williams, S.J.; Kobe, B.; Sieber, V.; Schembri, M.A.; Schenk, G.; Guddat, L.W.
Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 A resolution - a potential target for anti-tuberculosis drug discovery
FEBS J.
283
1184-1196
2016
BRENDA: Mycobacterium tuberculosis (P9WKJ7), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WKJ7)
Textmining: Bacteria, Pseudomonas aeruginosa, Fungi, Metazoa, Slackia exigua
Bastian, S.; Liu, X.; Meyerowitz, J.; Snow, C.; Chen, M.; Arnold, F.
Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli
Metab. Eng.
13
345-352
2011
Escherichia coli, Escherichia coli (P05793)
Verdel-Aranda, K.; Lopez-Cortina, S.T.; Hodgson, D.A.; Barona-Gomez, F.
Molecular annotation of ketol-acid reductoisomerases from Streptomyces reveals a novel amino acid biosynthesis interlock mediated by enzyme promiscuity
Microb. Biotechnol.
8
239-252
2015
BRENDA: Corynebacterium glutamicum, Escherichia coli, Streptomyces griseus, Streptomyces viridifaciens, Streptomyces pristinaespiralis, Streptomyces ambofaciens (A0A0K2AZ61), Streptomyces lividans (D6EC76), Streptomyces lividans (D6ERQ9), Streptomyces lividans, Streptomyces avermitilis (Q59818), Streptomyces coelicolor (Q9FBT8), Streptomyces coelicolor (Q9Z565), Streptomyces coelicolor, Streptomyces ambofaciens ATCC 23877 (A0A0K2AZ61), Streptomyces lividans TK24 (D6EC76), Streptomyces lividans TK24 (D6ERQ9), Streptomyces coelicolor ATCC BAA-471 (Q9Z565), Streptomyces coelicolor BAA-471 (Q9FBT8), Streptomyces avermitilis DSM 46492 (Q59818)
Textmining: Streptomyces, Corynebacterium
Brinkmann-Chen, S.; Flock, T.; Cahn, J.; Snow, C.; Brustad, E.; McIntosh, J.; Meinhold, P.; Zhang, L.; Arnold, F.
General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH
Proc. Natl. Acad. Sci. USA
110
10946-10951
2013
BRENDA: Methanococcus aeolicus (A6UW80), Alicyclobacillus acidocaldarius subsp. acidocaldarius (C8WR67), Methanococcus aeolicus DSM 17508 (A6UW80)
Textmining: Escherichia coli, Escherichia coli (P05793)
Zingle, C.; Tritsch, D.; Grosdemange-Billiard, C.; Rohmer, M.
Catechol-rhodanine derivatives: Specific and promiscuous inhibitors of Escherichia coli deoxyxylulose phosphate reductoisomerase (DXR)
Bioorg. Med. Chem.
22
3713-3719
2014
Escherichia coli, Escherichia coli (Q1RG16)
Lu, J.; Brigham, C.J.; Plassmeier, J.K.; Sinskey, A.J.
Characterization and modification of enzymes in the 2-ketoisovalerate biosynthesis pathway of Ralstonia eutropha H16
Appl. Microbiol. Biotechnol.
99
761-774
2015
Eutropha, Cupriavidus necator H16, Cupriavidus necator, Cupriavidus necator (Q0K7F8), Maniola tithonus
Zhang, B.; Zhang, X.M.; Wang, W.; Liu, Z.Q.; Zheng, Y.G.
Metabolic engineering of Escherichia coli for D-pantothenic acid production
Food Chem.
294
267-275
2019
Escherichia coli
Wun, S.J.; Johnson, L.A.; You, L.; McGeary, R.P.; Brueck, T.; Schenk, G.; Guddat, L.W.
Inhibition studies of ketol-acid reductoisomerases from pathogenic microorganisms
Arch. Biochem. Biophys.
692
108516
2020
Campylobacter jejuni, Mycobacterium tuberculosis (P9WKJ7), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WKJ7)
Wang, B.L.; Zhang, L.Y.; Liu, X.H.; Ma, Y.; Zhang, Y.; Li, Z.M.; Zhang, X.
Synthesis, biological activities and SAR studies of new 3-substitutedphenyl-4-substituted benzylideneamino-1,2,4-triazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors
Bioorg. Med. Chem. Lett.
27
5457-5462
2017
Oryza sativa Japonica Group (Q65XK0)
Yu, M.J.; Wu, J.; Chen, S.L.
Mechanism and inhibitor exploration with binuclear Mg ketol-acid reductoisomerase targeting the biosynthetic pathway of branched-chain amino acids
ChemBioChem
21
381-391
2020
BRENDA: Staphylococcus aureus (Q2FWK4), Staphylococcus aureus NCTC 8325 (Q2FWK4)
Textmining: Mammalia
Patel, K.M.; Teran, D.; Zheng, S.; Kandale, A.; Garcia, M.; Lv, Y.; Schembri, M.A.; McGeary, R.P.; Schenk, G.; Guddat, L.W.
Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogues that have biocidal activity
Chemistry
23
18289-18295
2017
Staphylococcus aureus (Q2FWK4), Staphylococcus aureus, Staphylococcus aureus NCTC 8325 (Q2FWK4)
Bayaraa, T.; Kurz, J.L.; Patel, K.M.; Hussein, W.M.; Bilyj, J.K.; West, N.P.; Schenk, G.; McGeary, R.P.; Guddat, L.W.
Discovery, synthesis and evaluation of a ketol-acid reductoisomerase inhibitor
Chemistry
26
8958-8968
2020
BRENDA: Mycobacterium tuberculosis (P9WKJ7), Mycobacterium tuberculosis, Staphylococcus aureus (Q2FWK4), Staphylococcus aureus, Staphylococcus aureus NCTC 8325 (Q2FWK4)
Textmining: Homo sapiens
Lin, X.; Kurz, J.L.; Patel, K.M.; Wun, S.J.; Hussein, W.M.; Lonhienne, T.; West, N.P.; McGeary, R.P.; Schenk, G.; Guddat, L.W.
Discovery of a pyrimidinedione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomerase
Chemistry
27
3130-3141
2021
Mycobacterium tuberculosis (A5U713), Mycobacterium tuberculosis (P9WKJ7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKJ7)
Kim, G.; Shin, D.; Lee, S.; Yun, J.; Lee, S.
Crystal structure of ILvC, a ketol-acid reductoisomerase, from Streptococcus pneumoniae
Crystals
9
551
2019
Streptococcus pneumoniae (Q04M32)
-
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