Reference on EC 1.1.1.41 - isocitrate dehydrogenase (NAD+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Plaut, G.W.E.
Isocitrate dehydrogenase
The Enzymes, 2nd Ed. (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. )
7
105-126
1963
Aspergillus niger, Bos taurus, Cavia porcellus, Columba livia, Homo sapiens, Pisum sativum, Rattus norvegicus, Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Glaeser, H.; Schlegel, H.G.
NADP- und NAD-spezifische dehydrogenase in Hydrogenomas eutropha stamm H 16
Arch. Microbiol.
86
327-337
1972
Cupriavidus necator
Manually annotated by BRENDA team
Cohen, P.F.; Colman, R.F.
Role of manganous ion in the kinetics of pig-heart NAD-specific isocitrate dehydrogenase
Eur. J. Biochem.
47
35-45
1974
Sus scrofa
Manually annotated by BRENDA team
Silinski, J.M.; Colman, R.F.
The kinetics of NAD-linked isocitrate dehydrogenase from calf heart
Biochim. Biophys. Acta
370
1-25
1974
Bos taurus
Manually annotated by BRENDA team
Alp, P.R.; Newsholme, E.A.; Zammit, V.A.
Activities of citrate synthase and NAD+-linked and NADP+-linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates
Biochem. J.
154
689-700
1976
Lepas anatifera, Locusta sp., Oryctes rhinoceros, Ovis aries, Periplaneta americana, Sarcophaga barbata, waterbug
Manually annotated by BRENDA team
Nabeshima, S.; Ishiyama, S.; Tanaka, A.; Fukui, S.
Partial purification and some kinetic properties of NAD-linked and NADP-linked isocitrate dehydrogenase from Candida tropicalis
Agric. Biol. Chem.
41
509-516
1977
Candida tropicalis
-
Manually annotated by BRENDA team
Ramachandran, N.; Colman, R.F.
Evidence for the presence of two nonidentical subunits in NAD-dependent isocitrate dehydrogenase of pig heart
Proc. Natl. Acad. Sci. USA
75
252-255
1978
Sus scrofa
Manually annotated by BRENDA team
Hoffmann, K.H.; Babel, W.
Regulation of NAD+- and NADP+-linked isocitrate dehydrogenase in the obligate methylotrophic bacterium Pseudomonas W6
Z. Allg. Mikrobiol.
20
399-404
1980
Pseudomonas sp., Pseudomonas sp. W 6
Manually annotated by BRENDA team
Willson, V.J.C.; Tripton, K.F.
The effect of pH on the allosteric behaviour of ox-brain NAD+-dependent isocitrate dehydrogenase
Eur. J. Biochem.
109
411-416
1980
Bos taurus
Manually annotated by BRENDA team
Willson, V.J.C.; Tripton, K.F.
The activation of ox-brain NAD+-dependent isocitrate dehydrogenase by magnesium ions
Eur. J. Biochem.
113
477-483
1981
Bos taurus
Manually annotated by BRENDA team
Ehrlich, R.S.; Hayman, S.; Ramachandran, N.; Colman, R.F.
Re-evaluation of molecular weight of pig heart NAD-specific isocitrate dehydrogenase
J. Biol. Chem.
256
10560-10564
1981
Sus scrofa
Manually annotated by BRENDA team
Gabriel, J.L.; Plaut, G.W.E.
Specific site inhibitors of NAD-specific isocitrate dehydrogenase from bovine heart
J. Biol. Chem.
257
8021-8029
1981
Bos taurus
Manually annotated by BRENDA team
Tezuka, T.; Laties, G.G.
Isolation and characterization of inner membrane-associated and matrix NAD-specific isocitrate dehydrogenase in potato mitochondria
Plant Physiol.
72
959-963
1982
Solanum tuberosum
Manually annotated by BRENDA team
Gabriel, J.L.; Plaut, G.W.E.
Inhibition of bovine heart NAD-specific isocitrate dehydrogenase by reduced pyridine nucleotides: modulation of inhibition by ADP, NAD+, Ca2+, citrate, and isocitrate
Biochemistry
23
2773-2778
1984
Bos taurus
Manually annotated by BRENDA team
Bulos, B.A.; Thomas, B.J.; Sacktor, B.
Calcium inhibition of the NAD+-linked isocitrate dehydrogenase from blowfly flight muscle mitochondria
J. Biol. Chem.
259
10232-10237
1984
Phormia regina
Manually annotated by BRENDA team
Gabriel, J.L.; Milner, R.; Plaut, G.W.E.
Inhibition and activation of bovine heart NAD-specific isocitrate dehydrogenase by ATP
Arch. Biochem. Biophys.
240
128-134
1985
Bos taurus
Manually annotated by BRENDA team
Gabriel, J.L.; Plaut, G.W.E.
NAD-specific isocitrate dehydrogenase from bovine heart. Interaction with Ca2+ chelators
Biochem. J.
229
817-822
1985
Bos taurus
Manually annotated by BRENDA team
Evans, C.T.; Ratledge, C.
The role of the mitochondrial NAD+:isocitrate dehydrogenase in lipid accumulation by the oleaginous yeast Rhodosporidium toruloides CBS 14
Can. J. Microbiol.
31
845-850
1985
Rhodotorula toruloides
-
Manually annotated by BRENDA team
Rutter, G.A.; Denton, R.M.
Regulation of NAD+-linked isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase by Ca2+ ions within toluene-permeabilized rat heart mitochondria. Interactions with regulation by adenine nucleotides and NADH/NAD+ ratios [published erratum appears in Biochem J 1988 Aug 1;253(3):935]
Biochem. J.
252
181-189
1988
Rattus norvegicus
Manually annotated by BRENDA team
Gabriel, J.L.; Plaut, G.W.E.
Citrate activation of NAD-specific isocitrate dehydrogenase from bovine heart
J. Biol. Chem.
259
1622-1628
1984
Bos taurus
Manually annotated by BRENDA team
Kim, Y.O.; Koh, H.J.; Kim, S.H.; Jo, S.H.; Huh, J.W.; Jeong, K.S.; Lee, I.J.; Song, B.J.; Huh, T.L.
Identification and functional characterization of a novel tissue-specific NAD+-dependent isocitrate dehydrogenase beta subunit isoform
J. Biol. Chem.
274
36866-36875
1999
Homo sapiens
Manually annotated by BRENDA team
Gabriel, J.L.; Plaut, G.W.E.
Kinetic regulation of yeast NAD-specific isocitrate dehydrogenase by citrate
Biochemistry
30
2594-2599
1991
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Panisko, E.A.; McAllister-Henn, L.
Subunit interactions of yeast NAD+-specific isocitrate dehydrogenase
J. Biol. Chem.
276
1204-1210
2001
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Anderson, S.L.; Minard, K.I.; McAllister-Henn, L.
Allosteric inhibition of NAD+-specific isocitrate dehydrogenase by a mitochondrial mRNA
Biochemistry
39
5623-5629
2000
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Martinez-Rivas, J.M.; Vega, J.M.
Purification and characterization of NAD-isocitrate dehydrogenase from Chlamydomonas reinhardtii
Plant Physiol.
118
249-255
1998
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
McIntosh, C.A.
Partial purification and characteristics of membrane-associated NAD+-dependent isocitrate dehydrogenase activity from etiolated pea mitochondria
Plant Sci.
129
9-20
1997
Pisum sativum
-
Manually annotated by BRENDA team
Huang, Y.C.; Kumar, A.; Colman, R.F.
Identification of the subunits and target peptides of pig heart NAD-specific isocitrate dehydrogenase modified by the affinity label 8-(4-bromo-2,3-dioxobutylthio)NAD
Arch. Biochem. Biophys.
348
207-218
1997
Sus scrofa
Manually annotated by BRENDA team
Alvarez-Villafane, E.; Soler, J.; del Valle, P.; Busto, F.; de Arriaga, D.
Two NAD+-dependent isocitrate dehydrogenase forms in Phycomyces blakesleeanus. Induction in response to acetate growth and characterization, kinetics, and regulation of both enzyme forms
Biochemistry
35
4741-4752
1996
Phycomyces blakesleeanus
Manually annotated by BRENDA team
Hurley, J.H.; Chen, R.; Dean, A.M.
Determinants of cofactor specificity in isocitrate dehydrogenase: structure of an engineered NADP+ to NAD+ specificity-reversal mutant
Biochemistry
35
5670-5678
1996
Escherichia coli
Manually annotated by BRENDA team
Anderson, S.L.; Schirf, V.; McAlister-Henn, L.
Effect of AMP on mRNA binding by yeast NAD+-specific isocitrate dehydrogenase
Biochemistry
41
7065-7073
2002
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Morgunov, I.G.; Solodovnikova, N.Y.; Sharyshev, A.A.; Kamzolova, S.V.; Finogenova, T.V.
Regulation of NAD(+)-dependent isocitrate dehydrogenase in the citrate producing yeast Yarrowia lipolytica
Biochemistry
69
1391-1398
2004
Yarrowia lipolytica
Manually annotated by BRENDA team
Igamberdiev, A.U.; Gardestrom, P.
Regulation of NAD- and NADP-dependent isocitrate dehydrogenases by reduction levels of pyridine nucleotides in mitochondria and cytosol of pea leaves
Biochim. Biophys. Acta
1606
117-125
2003
Pisum sativum
Manually annotated by BRENDA team
Pinheiro de Carvalho, M.A.A.; Popova, T.N.; Dos Santos, T.M.M.; Zherebtsov, N.A.
Effect of metabolites of gamma-aminobutyric shunt on activities of NAD- and NADP-isocitrate dehydrogenases and aconitate hydratase from higher plants
Biol. Bull.
30
236-242
2003
Pisum sativum, Zea mays
-
Manually annotated by BRENDA team
Inoue, H.; Tamura, T.; Ehara, N.; Nishito, A.; Nakayama, Y.; Maekawa, M.; Imada, K.; Tanaka, H.; Inagaki, K.
Biochemical and molecular characterization of the NAD(+)-dependent isocitrate dehydrogenase from the chemolithotroph Acidithiobacillus thiooxidans
FEMS Microbiol. Lett.
214
127-132
2002
Acidithiobacillus thiooxidans, Acidithiobacillus thiooxidans (Q8GAX0), Acidithiobacillus thiooxidans ON107 (Q8GAX0)
Manually annotated by BRENDA team
Lin, A.P.; McAlister-Henn, L.
Isocitrate binding at two functionally distinct sites in yeast NAD+-specific isocitrate dehydrogenase
J. Biol. Chem.
277
22475-22483
2002
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lin, A.P.; McAlister-Henn, L.
Homologous binding sites in yeast isocitrate dehydrogenase for cofactor (NAD+) and allosteric activator (AMP)
J. Biol. Chem.
278
12864-12872
2003
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Soundar, S.; Park, J.H.; Huh, T.L.; Colman, R.F.
Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase
J. Biol. Chem.
278
52146-52153
2003
Homo sapiens
Manually annotated by BRENDA team
Lin, M.; Behal, R.H.; Oliver, D.J.
Characterization of a mutation in the IDH-II subunit of the NAD+-dependent isocitrate dehydrogenase from Arabidopsis thaliana
Plant Sci.
166
983-988
2004
Arabidopsis thaliana, Arabidopsis thaliana Landsberg
Manually annotated by BRENDA team
Miyazaki, K.
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase
Biochem. Biophys. Res. Commun.
331
341-346
2005
Pyrococcus horikoshii
Manually annotated by BRENDA team
Mitchell, C.G.
Identification of a multienzyme complex of the tricarboxylic acid cycle enzymes containing citrate synthase isoenzymes from pseudomonas aeruginosa
Biochem. J.
313
769-774
1996
Pseudomonas aeruginosa
-
Manually annotated by BRENDA team
Hu, G.; Taylor, A.B.; McAlister-Henn, L.; Hart, P.J.
Crystallization and preliminary x-ray crystallographic analysis of yeast NAD+-specific isocitrate dehydrogenase. [Erratum to document cited in CA143:301281]
Acta Crystallogr. Sect. F
F62
709
2006
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Hu, G.; McAlister-Henn, L.
Novel allosteric properties produced by residue substitutions in the subunit interface of yeast NAD+-specific isocitrate dehydrogenase
Arch. Biochem. Biophys.
453
207-216
2006
Saccharomyces cerevisiae (P28241), Saccharomyces cerevisiae (P28834), Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
Manually annotated by BRENDA team
Anderson, S.L.; Lin, A.P.; McAlister-Henn, L.
Analysis of interactions with mitochondrial mRNA using mutant forms of yeast NAD(+)-specific isocitrate dehydrogenase
Biochemistry
44
16776-16784
2005
Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
Manually annotated by BRENDA team
Hu, G.; Lin, A.P.; McAlister-Henn, L.
Physiological consequences of loss of allosteric activation of yeast NAD+-specific isocitrate dehydrogenase
J. Biol. Chem.
281
16935-16942
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
Manually annotated by BRENDA team
Soundar, S.; Ohagan, M.; Fomulu, K.S.; Colman, R.F.
Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase
J. Biol. Chem.
281
21073-21081
2006
Homo sapiens
Manually annotated by BRENDA team
Watanabe, S.; Yasutake, Y.; Tanaka, I.; Takada, Y.
Elucidation of stability determinants of cold-adapted monomeric isocitrate dehydrogenase from a psychrophilic bacterium, Colwellia maris, by construction of chimeric enzymes
Microbiology
151
1083-1094
2005
Azotobacter vinelandii, Colwellia maris
Manually annotated by BRENDA team
Abiko, T.; Obara, M.; Ushioda, A.; Hayakawa, T.; Hodges, M.; Yamaya, T.
Localization of NAD-isocitrate dehydrogenase and glutamate dehydrogenase in rice roots: candidates for providing carbon skeletons to NADH-glutamate synthase
Plant Cell Physiol.
46
1724-1734
2005
Oryza sativa
Manually annotated by BRENDA team
Lemaitre, T.; Hodges, M.
Expression analysis of Arabidopsis thaliana NAD-dependent isocitrate dehydrogenase genes shows the presence of a functional subunit that is mainly expressed in the pollen and absent from vegetative organs
Plant Cell Physiol.
47
634-643
2006
Arabidopsis thaliana, Arabidopsis thaliana (O81796), Arabidopsis thaliana (P93032), Arabidopsis thaliana (Q8LFC0), Arabidopsis thaliana (Q8LG77), Arabidopsis thaliana (Q945K7)
Manually annotated by BRENDA team
Rodriguez-Arnedo, A.; Camacho, M.; Llorca, F.; Bonete, M.J.
Complete reversal of coenzyme specificity of isocitrate dehydrogenase from Haloferax volcanii
Protein J.
24
259-266
2005
Escherichia coli
Manually annotated by BRENDA team
Kalinina, O.V.; Gelfand, M.S.
Amino acid residues that determine functional specificity of NADP- and NAD-dependent isocitrate and isopropylmalate dehydrogenases
Proteins
64
1001-1009
2006
Escherichia coli
Manually annotated by BRENDA team
Lin, A.P.; Hakala, K.W.; Weintraub, S.T.; McAlister-Henn, L.
Suppression of metabolic defects of yeast isocitrate dehydrogenase and aconitase mutants by loss of citrate synthase
Arch. Biochem. Biophys.
474
205-212
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
Manually annotated by BRENDA team
Stokke, R.; Madern, D.; Fedoy, A.; Karlsen, S.; Birkeland, N.; Steen, I.H.
Biochemical characterization of isocitrate dehydrogenase from Methylococcus capsulatus reveals a unique NAD+-dependent homotetrameric enzyme
Arch. Microbiol.
187
361-370
2007
Methylococcus capsulatus
Manually annotated by BRENDA team
Bzymek, K.P.; Colman, R.F.
Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase
Biochemistry
46
5391-5397
2007
Homo sapiens
Manually annotated by BRENDA team
Kanamasa, S.; Tajima, S.; Park, E.Y.
Isocitrate dehydrogenase and isocitrate lyase are essential enzymes for riboflavin production in Ashbya gossypii
Biotechnol. Bioprocess Eng.
12
92-99
2007
Eremothecium gossypii
-
Manually annotated by BRENDA team
Taylor, A.B.; Hu, G.; Hart, P.J.; McAlister-Henn, L.
Allosteric motions in structures of yeast NAD+-specific isocitrate dehydrogenase
J. Biol. Chem.
283
10872-10880
2008
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lemaitre, T.; Urbanczyk-Wochniak, E.; Flesch, V.; Bismuth, E.; Fernie, A.R.; Hodges, M.
NAD-dependent isocitrate dehydrogenase mutants of Arabidopsis suggest the enzyme is not limiting for nitrogen assimilation
Plant Physiol.
144
1546-1558
2007
Arabidopsis thaliana (P93032), Arabidopsis thaliana (Q8LFC0), Arabidopsis thaliana (Q945K7)
Manually annotated by BRENDA team
Imada, K.; Tamura, T.; Takenaka, R.; Kobayashi, I.; Namba, K.; Inagaki, K.
Structure and quantum chemical analysis of NAD+-dependent isocitrate dehydrogenase: hydride transfer and co-factor specificity
Proteins
70
63-71
2008
Acidithiobacillus thiooxidans
Manually annotated by BRENDA team
Hatzopoulos, G.N.; Kefala, G.; Mueller-Dieckmann, J.
Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of isocitrate dehydrogenase 2 (Rv0066c) from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
64
1139-1142
2008
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Garcia, J.A.; Minard, K.I.; Lin, A.P.; McAlister-Henn, L.
Disulfide bond formation in yeast NAD+-specific isocitrate dehydrogenase
Biochemistry
48
8869-8878
2009
Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
Manually annotated by BRENDA team
Hartong, D.T.; Dange, M.; McGee, T.L.; Berson, E.L.; Dryja, T.P.; Colman, R.F.
Novel insights into the contributions of isocitrate dehydrogenases to the Krebs cycle from patients with retinitis pigmentosa
Nat. Genet.
40
1230-1234
2008
Homo sapiens (O43837)
Manually annotated by BRENDA team
Kang, M.R.; Kim, M.S.; Oh, J.E.; Kim, Y.R.; Song, S.Y.; Seo, S.I.; Lee, J.Y.; Yoo, N.J.; Lee, S.H.
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
Int. J. Cancer
125
353-355
2009
Homo sapiens
Manually annotated by BRENDA team
Dange, M.; Colman, R.F.
Each conserved active site tyr in the three subunits of human isocitrate dehydrogenase has a different function
J. Biol. Chem.
285
20520-20525
2010
Homo sapiens
Manually annotated by BRENDA team
Sienkiewicz-Porzucek, A.; Sulpice, R.; Osorio, S.; Krahnert, I.; Leisse, A.; Urbanczyk-Wochniak, E.; Hodges, M.; Fernie, A.R.; Nunes-Nesi, A.
Mild reductions in mitochondrial NAD-dependent isocitrate dehydrogenase activity result in altered nitrate assimilation and pigmentation but do not impact growth
Mol. Plant
3
156-173
2010
Solanum lycopersicum
Manually annotated by BRENDA team
Zhang, N.; Gur, A.; Gibon, Y.; Sulpice, R.; Flint-Garcia, S.; McMullen, M.D.; Stitt, M.; Buckler, E.S.
Genetic analysis of central carbon metabolism unveils an amino acid substitution that alters maize NAD-dependent isocitrate dehydrogenase activity
PLoS ONE
5
e9991
2010
Zea mays
Manually annotated by BRENDA team
Yang, F.; Zhang, S.; Zhou, Y.J.; Zhu, Z.; Lin, X.; Zhao, Z.K.
Characterization of the mitochondrial NAD+-dependent isocitrate dehydrogenase of the oleaginous yeast Rhodosporidium toruloides
Appl. Microbiol. Biotechnol.
94
1095-1105
2012
Rhodotorula toruloides (G1APK2), Rhodotorula toruloides (G1APK3), Rhodotorula toruloides, Rhodotorula toruloides AS 2.1389 (G1APK2), Rhodotorula toruloides AS 2.1389 (G1APK3)
Manually annotated by BRENDA team
McAlister-Henn, L.
Ligand binding and structural changes associated with allostery in yeast NAD+-specific isocitrate dehydrogenase
Arch. Biochem. Biophys.
519
112-117
2012
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Steen, I.H.; Lien, T.; Madsen, M.S.; Birkeland, N.K.
Identification of cofactor discrimination sites in NAD-isocitrate dehydrogenase from Pyrococcus furiosus
Arch. Microbiol.
178
297-300
2002
Pyrococcus furiosus, Pyrococcus furiosus (Q8U488)
Manually annotated by BRENDA team
Lin, A.P.; McAlister-Henn, L.
Basis for half-site ligand binding in yeast NAD+-specific isocitrate dehydrogenase
Biochemistry
50
8241-8250
2011
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Wang, P.; Jin, M.; Zhu, G.
Biochemical and molecular characterization of NAD(+)-dependent isocitrate dehydrogenase from the ethanologenic bacterium Zymomonas mobilis
FEMS Microbiol. Lett.
327
134-141
2012
Zymomonas mobilis, Zymomonas mobilis ATCC10988
Manually annotated by BRENDA team
Wang, P.; Song, P.; Jin, M.; Zhu, G.
Isocitrate dehydrogenase from Streptococcus mutans: biochemical properties and evaluation of a putative phosphorylation site at Ser102
PLoS ONE
8
e58918
2013
Streptococcus mutans
Manually annotated by BRENDA team
Steen, I.H.; Madern, D.; Karlström, M.; Lien, T.; Ladenstein, R.; Birkeland, N.K.
Comparison of isocitrate dehydrogenase from three hyperthermophiles reveals differences in thermostability, cofactor specificity, oligomeric state, and phylogenetic affiliation
J. Biol. Chem.
276
43924-43931
2001
Pyrococcus furiosus, Pyrococcus furiosus (Q8U488)
Manually annotated by BRENDA team