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Information on EC 1.1.1.41 - isocitrate dehydrogenase (NAD+)

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IUBMB Comments
Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.42, isocitrate dehydrogenase (NADP+), oxalosuccinate cannot be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm . The enzyme from some species can also use NADP+ but much more slowly .
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This record set is specific for:
UNIPROT: P93032
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
Synonyms
isocitrate dehydrogenase, isocitrate dehydrogenase 2, isocitric dehydrogenase, nad-dependent isocitrate dehydrogenase, idh3a, nad-idh, nad-isocitrate dehydrogenase, nad-icdh, nad+-dependent isocitrate dehydrogenase, nad-linked isocitrate dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NAD-dependent isocitrate dehydrogenase
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beta-ketoglutaric-isocitric carboxylase
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IDH1
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isocitric acid dehydrogenase
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isocitric dehydrogenase
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NAD dependent isocitrate dehydrogenase
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NAD isocitrate dehydrogenase
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NAD isocitric dehydrogenase
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NAD+-specific ICDH
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NAD-linked isocitrate dehydrogenase
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NAD-specific isocitrate dehydrogenase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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reduction
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oxidative decarboxylation
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reductive carboxylation
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SYSTEMATIC NAME
IUBMB Comments
isocitrate:NAD+ oxidoreductase (decarboxylating)
Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.42, isocitrate dehydrogenase (NADP+), oxalosuccinate cannot be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm [7]. The enzyme from some species can also use NADP+ but much more slowly [9].
CAS REGISTRY NUMBER
COMMENTARY hide
9001-58-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
in leaves, the IDH genes are highly expressed in the veins, and to a lesser extent in mesophyll cells. Cauline leaf, rosette, juvenile leaf, adult leaf, senescent leaf
Manually annotated by BRENDA team
lateral root and elongation zone
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
IDH2_ARATH
367
0
39590
Swiss-Prot
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lemaitre, T.; Hodges, M.
Expression analysis of Arabidopsis thaliana NAD-dependent isocitrate dehydrogenase genes shows the presence of a functional subunit that is mainly expressed in the pollen and absent from vegetative organs
Plant Cell Physiol.
47
634-643
2006
Arabidopsis thaliana, Arabidopsis thaliana (O81796), Arabidopsis thaliana (P93032), Arabidopsis thaliana (Q8LFC0), Arabidopsis thaliana (Q8LG77), Arabidopsis thaliana (Q945K7)
Manually annotated by BRENDA team
Lemaitre, T.; Urbanczyk-Wochniak, E.; Flesch, V.; Bismuth, E.; Fernie, A.R.; Hodges, M.
NAD-dependent isocitrate dehydrogenase mutants of Arabidopsis suggest the enzyme is not limiting for nitrogen assimilation
Plant Physiol.
144
1546-1558
2007
Arabidopsis thaliana (P93032), Arabidopsis thaliana (Q8LFC0), Arabidopsis thaliana (Q945K7)
Manually annotated by BRENDA team