Disease on EC 1.1.1.39 - malate dehydrogenase (decarboxylating)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Carcinogenesis
The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas.
Carcinoma, Hepatocellular
Activities of enzymes of lipid metabolism in Morris hepatoma 7800 C1 cells.
Mitochondrial malic enzymes. Mitochondrial NAD(P)+-dependent malic enzyme activity and malate-dependent pyruvate formation are progression-linked in Morris hepatomas.
Purification, kinetic behavior, and regulation of NAD(P)+ malic enzyme of tumor mitochondria.
Epilepsy, Generalized
Association analysis of malic enzyme 2 gene polymorphisms with idiopathic generalized epilepsy.
Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy.
Friedreich Ataxia
Cardiac malic enzyme in Friedreich's disease.
Friedreich ataxia: III. Mitochondrial malic enzyme deficiency.
Friedreich's ataxia: malic enzyme activity in cellular fractions of cultured skin fibroblasts.
Friedreich's disease: IV. Reduced mitochondrial malic enzyme activity in heterozygotes.
Mitochondrial malic enzyme in Friedreich's ataxia: failure to demonstrate reduced activity in cultured fibroblasts.
Normal fibroblast mitochondrial malic enzyme activity in Friedreich's ataxia.
Normal mitochondrial malic enzyme levels in Friedreich's ataxia fibroblasts.
Glioma
The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas.
glucose-6-phosphatase deficiency
Analysis of the albino-locus region of the mouse: IV. Characterization of 34 deficiencies.
Glycogen Storage Disease Type I
Analysis of the albino-locus region of the mouse: IV. Characterization of 34 deficiencies.
Insulinoma
Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells.
Leukemia
Enzyme activities of NADPH-forming metabolic pathways in normal and leukemic leukocytes.
Leukemia, Erythroblastic, Acute
Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2.
Leukemia, Myeloid, Acute
Enzyme activities of NADPH-forming metabolic pathways in normal and leukemic leukocytes.
Malaria
Mitochondrial NAD+-dependent malic enzyme from Anopheles stephensi: a possible novel target for malaria mosquito control.
malate dehydrogenase (decarboxylating) deficiency
Friedreich ataxia: III. Mitochondrial malic enzyme deficiency.
Friedreich's ataxia: malic enzyme activity in cellular fractions of cultured skin fibroblasts.
malate dehydrogenase (oxaloacetate-decarboxylating) deficiency
Friedreich ataxia: III. Mitochondrial malic enzyme deficiency.
Melanoma
Metabolic Vulnerability in Melanoma: A ME2 (Me Too) Story.
Neoplasms
Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme: a new class of oxidative decarboxylases.
Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling.
Malic enzyme and malate dehydrogenase activities in rat tracheal epithelial cells during the progression of neoplasia.
Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate.
Purification and characterization of the cytosolic NADP(+)-dependent malic enzyme from human breast cancer cell line.
Purification of tumor mitochondrial malic enzyme by specific ligand affinity chromatography.
The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme.