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Information on EC 1.1.1.38 - malate dehydrogenase (oxaloacetate-decarboxylating) and Organism(s) Mus musculus and UniProt Accession Q99KE1

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EC Tree
IUBMB Comments
Unlike EC 1.1.1.39, malate dehydrogenase (decarboxylating), this enzyme can also decarboxylate oxaloacetate. cf. EC 1.1.1.40, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+).
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This record set is specific for:
Mus musculus
UNIPROT: Q99KE1
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
Synonyms
malic enzyme, nad-me, nad-malic enzyme, m-nad(p)-me, malic enzyme 2, mitochondrial nad(p)+-dependent malic enzyme, mitochondrial nad-malic enzyme, nad+-dependent malic enzyme, mitochondrial nad(p) malic enzyme, malate dehydrogenase (oxaloacetate-decarboxylating), more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malic enzyme 2
-
ME2
mitochondrial NAD-dependent isoform of malic enzyme
mitochondrial malic enzyme ME2
-
mitochondrial NAD(P) malic enzyme ME2
-
malic enzyme
-
-
-
-
NAD-malic enzyme
-
-
-
-
NAD-ME
-
-
-
-
NAD-specific malic enzyme
-
-
-
-
pyruvic-malic carboxylase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
oxidative decarboxylation
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)
Unlike EC 1.1.1.39, malate dehydrogenase (decarboxylating), this enzyme can also decarboxylate oxaloacetate. cf. EC 1.1.1.40, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+).
CAS REGISTRY NUMBER
COMMENTARY hide
9080-52-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-malate + NAD+
pyruvate + CO2 + NADH
show the reaction diagram
-
-
-
?
(S)-malate + NAD+
pyruvate + CO2 + NADH + H+
show the reaction diagram
-
-
-
r
pyruvate + CO2 + NADH + H+
(S)-malate + NAD+
show the reaction diagram
-
-
-
r
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(S)-malate + NAD+
pyruvate + CO2 + NADH + H+
show the reaction diagram
-
-
-
r
pyruvate + CO2 + NADH + H+
(S)-malate + NAD+
show the reaction diagram
-
-
-
r
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
knockdown of isoform Me2 markedly reduces the glycolytic flux and impairs osteoblast proliferation and differentiation
metabolism
isoform Me2 funnels glucose carbons into malate-aspartate shuttle to sustain glycolysis
physiological function
the mitochondrial malic enzyme isoform Me2 functionally couples the mitochondria with aerobic glycolysis in osteoblasts
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MAOM_MOUSE
589
0
65799
Swiss-Prot
Mitochondrion (Reliability: 3)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
MacDonald, M.J.; Longacre, M.J.; Kendrick, M.A.
Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells
Arch. Biochem. Biophys.
488
100-104
2009
Rattus norvegicus, Homo sapiens (P23368), Mus musculus (Q99KE1)
Manually annotated by BRENDA team
Lee, W.; Ji, X.; Nissim, I.; Long, F.
Malic enzyme couples mitochondria with aero32905773bic glycolysis in osteoblasts
Cell Rep.
32
108108
2020
Mus musculus (Q99KE1), Mus musculus
Manually annotated by BRENDA team