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Enzyme Nomenclature
Information on EC 1.1.1.349 - norsolorinic acid ketoreductase
Word Map on EC 1.1.1.349
- 1.1.1.349
-
orphan
- aflatoxin
-
neuron-derived
- parasiticus
-
ngfi-b
-
receptor-1
- flavus
-
aflatoxin-inducing
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carbapenem-hydrolyzing
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aflatoxigenic
-
efs-induced
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The expected taxonomic range for this enzyme is: Aspergillus parasiticus
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EC NUMBER 
COMMENTARY 
1.1.1.349
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RECOMMENDED NAME
GeneOntology No.
norsolorinic acid ketoreductase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(1'S)-averantin + NADP+ = norsolorinic acid + NADPH + H+
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-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
(1'S)-averantin:NADP+ oxidoreductase
Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
malfunction
inactivation of the nor-1 gene leads to accumulation of norsolorinic acid and production of reduced levels of aflatoxin
malfunction
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inactivation of the nor-1 gene leads to accumulation of norsolorinic acid and production of reduced levels of aflatoxin
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malfunction
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inactivation of the nor-1 gene leads to accumulation of norsolorinic acid and production of reduced levels of aflatoxin
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metabolism
the nor-I gene is functionally involved in aflatoxin biosynthesis
metabolism
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the nor-I gene is functionally involved in aflatoxin biosynthesis
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metabolism
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the nor-I gene is functionally involved in aflatoxin biosynthesis
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(1'S)-averantin + NADP+
norsolorinic acid + NADPH + H+
-
-
-
-
r
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
-
-
-
?
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
-
-
-
-
?
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
-
-
-
-
r
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
-
-
-
?
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
-
-
-
-
?
additional information
?
-
-
the enzyme cannot use (1’R)-averantin as substrate in the reverse reaction
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-
-
additional information
?
-
-
the enzyme cannot use (1’R)-averantin as substrate in the reverse reaction
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-
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
Q00278
-
-
-
?
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
Q00278
-
-
-
?
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
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-
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
32000
-
x * 32000, SDS-PAGE, two recombinant Nor-1 proteins with apparent 32000 (major) and 36000 Da (minor) masses are detected
36000
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x * 36000, SDS-PAGE, two recombinant Nor-1 proteins with apparent 32000 (major) and 36000 Da (minor) masses are detected
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
-
x * 32000, SDS-PAGE, two recombinant Nor-1 proteins with apparent 32000 (major) and 36000 Da (minor) masses are detected; x * 36000, SDS-PAGE, two recombinant Nor-1 proteins with apparent 32000 (major) and 36000 Da (minor) masses are detected
?
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x * 32000, SDS-PAGE, two recombinant Nor-1 proteins with apparent 32000 (major) and 36000 Da (minor) masses are detected; x * 36000, SDS-PAGE, two recombinant Nor-1 proteins with apparent 32000 (major) and 36000 Da (minor) masses are detected
-
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.1.1.349)
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