Information on EC 1.1.1.338 - (2R)-3-sulfolactate dehydrogenase (NADP+)

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The expected taxonomic range for this enzyme is: Chromohalobacter salexigens

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EC NUMBER
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1.1.1.338
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RECOMMENDED NAME
GeneOntology No.
(2R)-3-sulfolactate dehydrogenase (NADP+)
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REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
(2R)-3-sulfolactate + NADP+ = 3-sulfopyruvate + NADPH + H+
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Cysteine and methionine metabolism
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Microbial metabolism in diverse environments
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sulfolactate degradation I
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SYSTEMATIC NAME
IUBMB Comments
(2R)-3-sulfolactate:NADP+ oxidoreductase
The enzyme from the bacterium Chromohalobacter salexigens can only utilize NADP+. It functions both biosynthetically in coenzyme M biosynthesis and degradatively, in the degradation of sulfolactate. It can not use (S)-malate and (S)-lactate.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
DSM 3043
UniProt
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
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LITERATURE
(Substrate)
COMMENTARY
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LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-3-sulfolactate + NADP+
3-sulfopyruvate + NADPH + H+
show the reaction diagram
specific activity for oxidation of sulfolactate is about 5% of the activity for reduction of 3-sulfopyruvate
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r
3-sulfopyruvate + NADPH + H+
(S)-3-sulfolactate + NADP+
show the reaction diagram
specific activity for oxidation of sulfolactate is about 5% of the activity for reduction of 3-sulfopyruvate
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r
additional information
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no substrate: pyruvate, oxaloacetate, (S)-malate, (S)-lactate, (R)-malate, (R)-lactate
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COFACTOR
ORGANISM
UNIPROT
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LITERATURE
IMAGE
additional information
no cosubstrate: NADH
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
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LITERATURE
IMAGE
19
(S)-3-sulfolactate
pH 9.0, 23°C
0.14
3-sulfopyruvate
pH 9.0, 23°C
1.2
NADP+
pH 9.0, 23°C
0.1
NADPH
pH 9.0, 23°C
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37000
2 * 37000, SDS-PAGE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
2 * 37000, SDS-PAGE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-18°C, stable against freezing and thawing
4°C, stable for several weeks
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression is induced by growth on sulfolactate
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LINKS TO OTHER DATABASES (specific for EC-Number 1.1.1.338)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)