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Information on EC 1.1.1.330 - very-long-chain 3-oxoacyl-CoA reductase and Organism(s) Saccharomyces cerevisiae and UniProt Accession P38286

for references in articles please use BRENDA:EC1.1.1.330
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IUBMB Comments
The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. The enzyme is active with substrates with chain length of C16 to C34, depending on the species. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase.
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Saccharomyces cerevisiae
UNIPROT: P38286
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The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
ybr159w, ifa38, very-long-chain 3-oxoacyl-coa reductase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IFA38
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-
-
-
KCR
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-
-
-
very-long-chain 3-ketoacyl-CoA reductase
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-
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-
very-long-chain beta-ketoacyl-CoA reductase
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-
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-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
(3R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase
The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. The enzyme is active with substrates with chain length of C16 to C34, depending on the species. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-40-4
cf. EC 1.1.1.35
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Beaudoin, F.; Gable, K.; Sayanova, O.; Dunn, T.; Napier, J.
A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase
J. Biol. Chem.
277
11481-11488
2002
Saccharomyces cerevisiae (P38286), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Han, G.; Gable, K.; Kohlwein, S.; Beaudoin, F.; Napier, J.; Dunn, T.
The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase
J. Biol. Chem.
277
35440-35449
2002
Saccharomyces cerevisiae (P38286), Saccharomyces cerevisiae
Manually annotated by BRENDA team