Information on EC 1.1.1.329 - 2-deoxy-scyllo-inosamine dehydrogenase

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The expected taxonomic range for this enzyme is: Streptomyces

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EC NUMBER
COMMENTARY hide
1.1.1.329
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RECOMMENDED NAME
GeneOntology No.
2-deoxy-scyllo-inosamine dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-deoxy-scyllo-inosamine + NAD(P)+ = 3-amino-2,3-dideoxy-scyllo-inosose + NAD(P)H + H+
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
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kanamycin biosynthesis
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Neomycin, kanamycin and gentamicin biosynthesis
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paromamine biosynthesis I
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SYSTEMATIC NAME
IUBMB Comments
2-deoxy-scyllo-inosamine:NAD(P)+ 1-oxidoreductase
Requires zinc. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, neomycin and ribostamycin. cf. EC 1.1.99.38, 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent).
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CAS REGISTRY NUMBER
COMMENTARY hide
99332-63-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-deoxy-scyllo-inosamine + NAD+
3-amino-2,3-dideoxy-scyllo-inosose + NADH + H+
show the reaction diagram
2-deoxy-scyllo-inosamine + NADP+
3-amino-2,3-dideoxy-scyllo-inosose + NADPH + H+
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
enzyme accepts both NAD+ and NADP+
NADP+
enzyme accepts both NAD+ and NADP+
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
expression in Streptomyces lividans
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LINKS TO OTHER DATABASES (specific for EC-Number 1.1.1.329)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)