Information on EC 1.1.1.314 - germacrene A alcohol dehydrogenase

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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
1.1.1.314
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RECOMMENDED NAME
GeneOntology No.
germacrene A alcohol dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
germacra-1(10),4,11(13)-trien-12-al + NADP+ + H2O = germacra-1(10),4,11(13)-trien-12-oate + NADPH + 2 H+
show the reaction diagram
(1b)
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germacra-1(10),4,11(13)-trien-12-ol + 2 NADP+ + H2O = germacra-1(10),4,11(13)-trien-12-oate + 2 NADPH + 3 H+
show the reaction diagram
overall reaction
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-
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germacra-1(10),4,11(13)-trien-12-ol + NADP+ = germacra-1(10),4,11(13)-trien-12-al + NADPH + H+
show the reaction diagram
(1a)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Sesquiterpenoid and triterpenoid biosynthesis
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Biosynthesis of secondary metabolites
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SYSTEMATIC NAME
IUBMB Comments
germacra-1(10),4,11(13)-trien-12-ol:NADP+ oxidoreductase
In Lactuca sativa EC 1.1.1.314 is a mutifunctional enzyme with EC 1.14.13.123, germacrene A hydroxylase [2].
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
germacra-1(10),4,11(13)-trien-12-ol + 2 NADP+ + H2O
germacra-1(10),4,11(13)-trien-12-oate + 2 NADPH + 3 H+
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADP+
-
dependent on
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
54900
calculated from amino acid sequence
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae strain YPL 154C:Pep4 KO
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LINKS TO OTHER DATABASES (specific for EC-Number 1.1.1.314)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)