Information on EC 1.1.1.291 - 2-hydroxymethylglutarate dehydrogenase

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The expected taxonomic range for this enzyme is: Eubacterium barkeri

EC NUMBER
COMMENTARY
1.1.1.291
-
RECOMMENDED NAME
GeneOntology No.
2-hydroxymethylglutarate dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(S)-2-hydroxymethylglutarate + NAD+ = 2-formylglutarate + NADH + H+
show the reaction diagram
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-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Nicotinate and nicotinamide metabolism
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-
nicotinate degradation III
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SYSTEMATIC NAME
IUBMB Comments
(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase
NADP+ cannot replace NAD+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 3.5.2.18 (enamidase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Delta-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase).
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-formylglutarate + NADH + H+
2-hydroxymethylglutarate + NAD+
show the reaction diagram
-
the enzyme forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri
-
-
?
2-hydroxymethylglutarate + NAD+
2-formylglutarate + NADH + H+
show the reaction diagram
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-
-
-
r
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-formylglutarate + NADH + H+
2-hydroxymethylglutarate + NAD+
show the reaction diagram
-
the enzyme forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NAD+
-
no activity with NADP+
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1.1
2-hydroxymethylglutarate
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-
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
tetramer
-
4 * 32000, SDS-PAGE
OXIDATION STABILITY
ORGANISM
UNIPROT
LITERATURE
instability under anaerobic conditions
-
670692
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
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