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NADP+ cannot replace NAD+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 220.127.116.11 (nicotinate dehydrogenase), EC 18.104.22.168 (6-hydroxynicotinate reductase), EC 22.214.171.124 (enamidase), EC 126.96.36.199 (2-methyleneglutarate mutase), EC 188.8.131.52 (methylitaconate Delta-isomerase), EC 184.108.40.206 (dimethylmaleate hydratase) and EC 220.127.116.11 (2,3-dimethylmalate lyase).