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Information on EC 1.1.1.272 - D-2-hydroxyacid dehydrogenase (NADP+) and Organism(s) Methanocaldococcus jannaschii and UniProt Accession Q60176

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EC Tree
IUBMB Comments
This enzyme, characterized from the halophilic archaeon Haloferax mediterranei and the mold Aspergillus oryzae, catalyses a stereospecific reduction of 2-oxocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. The enzyme prefers substrates with a main chain of 5 carbons (such as 4-methyl-2-oxopentanoate) to those with a shorter chain, and can use NADH with much lower efficiency. cf. EC 1.1.1.345, (D)-2-hydroxyacid dehydrogenase (NAD+).
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Methanocaldococcus jannaschii
UNIPROT: Q60176
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
d-2-hydroxyacid dehydrogenase, d-isomer specific 2-hydroxyacid dehydrogenase, d2-hdh, 2hadh, l-sulfolactate dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
(R)-2-hydroxyacid dehydrogenase
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(R)-sulfolactate dehydrogenase
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(R)-sulfolactate:NAD(P)+ oxidoreductase
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L-sulfolactate dehydrogenase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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reduction
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SYSTEMATIC NAME
IUBMB Comments
(R)-2-hydroxycarboxylate:NADP+ oxidoreductase
This enzyme, characterized from the halophilic archaeon Haloferax mediterranei and the mold Aspergillus oryzae, catalyses a stereospecific reduction of 2-oxocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. The enzyme prefers substrates with a main chain of 5 carbons (such as 4-methyl-2-oxopentanoate) to those with a shorter chain, and can use NADH with much lower efficiency. cf. EC 1.1.1.345, (D)-2-hydroxyacid dehydrogenase (NAD+).
CAS REGISTRY NUMBER
COMMENTARY hide
81210-65-3
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