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Information on EC 1.1.1.271 - GDP-L-fucose synthase and Organism(s) Drosophila melanogaster and UniProt Accession Q9W1X8

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EC Tree
     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.271 GDP-L-fucose synthase
IUBMB Comments
Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent.
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This record set is specific for:
Drosophila melanogaster
UNIPROT: Q9W1X8
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The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
tsta3, fx protein, gdp-l-fucose synthase, gdp-fucose synthetase, transplantation antigen p35b, gdp-4-keto-6-deoxy-d-mannose epimerase/reductase, gdp-4-keto-6-deoxy-d-mannose-3,5-epimerase-4-reductase, gdp-4-keto-6-deoxymannose-3,5-epimerase-4-reductase, gdp-fucose synthase, gdp-keto-6-deoxymannose 3,5-epimerase/4-reductase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
FX protein
in humans
GDP-keto-6-deoxymannose 3,5-epimerase/4-reductase
-
P35B tumour rejection antigen
in mice
FX protein
-
-
-
-
GDP-4-keto-6-D-deoxymannose epimerase-reductase
-
-
-
-
GDP-4-keto-6-deoxy-D-mannose epimerase-reductase
-
-
-
-
GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase
-
-
-
-
GDP-4-keto-6-deoxymannose 3,5-epimerase 4-reductase
-
-
-
-
GDP-4-keto-6-deoxymannose epimerase-reductase
-
-
-
-
GDP-fucose synthetase
-
-
-
-
GDP-L-fucose synthetase
-
-
-
-
guanosine diphosphofucose synthetase
-
-
-
-
Red cell NADP(H)-binding protein
-
-
-
-
Transplantation antigen P35B
-
-
-
-
Tum-P35B antigen
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
GDP-beta-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)
Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent.
CAS REGISTRY NUMBER
COMMENTARY hide
113756-18-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FCL_DROME
321
0
36123
Swiss-Prot
other Location (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rhomberg, S.; Fuchsluger, C.; Rendi?, D.; Paschinger, K.; Jantsch, V.; Kosma, P.; Wilson, I.B.
Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster
FEBS J.
273
2244-2256
2006
Caenorhabditis elegans (G5EER4), Caenorhabditis elegans, Drosophila melanogaster (Q9W1X8), Drosophila melanogaster
Manually annotated by BRENDA team