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Information on EC 1.1.1.27 - L-lactate dehydrogenase and Organism(s) Sphyraena lucasana and UniProt Accession O13278

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EC Tree
IUBMB Comments
Also oxidizes other (S)-2-hydroxymonocarboxylic acids. NADP+ also acts, more slowly, with the animal, but not the bacterial, enzyme.
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This record set is specific for:
Sphyraena lucasana
UNIPROT: O13278
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Word Map
The taxonomic range for the selected organisms is: Sphyraena lucasana
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
Synonyms
lactate dehydrogenase, lactic dehydrogenase, ldh-a, lactate dehydrogenase a, l-lactate dehydrogenase, ldh-5, lactic acid dehydrogenase, ldh-1, pfldh, alpha-hydroxybutyrate dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dehydrogenase, lactate
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Epsilon crystallin
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epsilon-crystallin
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Immunogenic protein p36
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L(+)-nLDH
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-
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L-(+)-lactate dehydrogenase
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L-lactic acid dehydrogenase
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L-lactic dehydrogenase
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L-LDH
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lactate dehydrogenase
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lactate dehydrogenase NAD-dependent
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lactic acid dehydrogenase
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lactic dehydrogenase
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LDH
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NAD-lactate dehydrogenase
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proteins, specific or class, anoxic stress response, p34
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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reduction
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SYSTEMATIC NAME
IUBMB Comments
(S)-lactate:NAD+ oxidoreductase
Also oxidizes other (S)-2-hydroxymonocarboxylic acids. NADP+ also acts, more slowly, with the animal, but not the bacterial, enzyme.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-60-9
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
pyruvate + NADH + H+
(S)-lactate + NAD+
show the reaction diagram
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-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.26
pyruvate
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Uniprot
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
LDHA_SPHLU
332
0
36343
Swiss-Prot
other Location (Reliability: 2)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D8G
no measurable effect on the Km value for pyruvate, increased thermal stability
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Holland, L.Z.; McFall-Ngai, M.; Somero, G.N.
Evolution of lactate dehydrogenase-A homologs of barracuda fishes (genus Sphyraena) from different thermal environments: differences in kinetic properties and thermal stability are due to amino acid substitutions outside the active site
Biochemistry
36
3207-3215
1997
Sphyraena barracuda, Sphyraena ensis, Sphyraena helleri, Sphyraena argentea (O13276), Sphyraena argentea, Sphyraena idiastes (O13277), Sphyraena idiastes, Sphyraena lucasana (O13278), Sphyraena lucasana
Manually annotated by BRENDA team