Information on EC 1.1.1.205 - IMP dehydrogenase and Organism(s) Trypanosoma brucei brucei and UniProt Accession P50098

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This record set is specific for:
Trypanosoma brucei brucei
UNIPROT: P50098


The taxonomic range for the selected organisms is: Trypanosoma brucei brucei

The enzyme appears in selected viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.1.1.205
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RECOMMENDED NAME
GeneOntology No.
IMP dehydrogenase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
purine metabolism
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Purine metabolism
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Drug metabolism - other enzymes
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Metabolic pathways
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Biosynthesis of secondary metabolites
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adenosine nucleotides degradation I
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inosine 5'-phosphate degradation
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guanosine ribonucleotides de novo biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
IMP:NAD+ oxidoreductase
The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-93-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-(1,3,4-thiadiazol-2-yl)hex-4-enamide}
14.50% inhibition at 0.001 mg
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(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-(1,3-thiazol-2-yl)hex-4-enamide}
22.27% inhibition at 0.001 mg
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(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-(1H-1,2,4-triazol-5-yl)hex-4-enamide}
46.13% inhibition at 0.001 mg
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(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-(1H-tetrazol-5-yl)hex-4-enamide}
22.99% inhibition at 0.001 mg
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(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-(4H-1,2,4-triazol-4-yl)hex-4-enamide}
14.29% inhibition at 0.001 mg
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(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-(pyridin-2-yl)hex-4-enamide}
7.83% inhibition at 0.001 mg
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(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enethioic S-acid}
11.56% inhibition at 0.001 mg
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(4E)-N-hydroxy-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide}
5.24% inhibition at 0.001 mg
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7-hydroxy-5-methoxy-4-methyl-6-{(2E)-3-methyl-6-[(2R)-oxiran-2-yl]-6-oxohex-2-en-1-yl}-2-benzofuran-1(3H)-one}
9.03% inhibition at 0.001 mg
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7-hydroxy-5-methoxy-4-methyl-6-{(2E)-3-methyl-6-[(2S)-oxiran-2-yl]-6-oxohex-2-en-1-yl}-2-benzofuran-1(3H)-one}
9.28% inhibition at 0.001 mg
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Mycophenolic acid
82.99% inhibition at 0.001 mg, inhibits the enzyme activity and leads to complete inhibition of proliferation of Trypanosoma at below 0.001 mM. Mycophenolic acid derivatives can act as trypanocidal drugs with trypanocidal activity
Pentamidine
complete inhibition at 500 ng/ml
S-prop-1-en-2-yl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enethioate}
16.47% inhibition at 0.001 mg
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