Information on EC 1.1.1.190 - indole-3-acetaldehyde reductase (NADH)

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The expected taxonomic range for this enzyme is: Gunneridae

EC NUMBER
COMMENTARY hide
1.1.1.190
-
RECOMMENDED NAME
GeneOntology No.
indole-3-acetaldehyde reductase (NADH)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(indol-3-yl)ethanol + NAD+ = (indol-3-yl)acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
L-tryptophan degradation VIII (to tryptophol)
-
-
tryptophan metabolism
-
-
Tryptophan metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
(indol-3-yl)ethanol:NAD+ oxidoreductase
-
CAS REGISTRY NUMBER
COMMENTARY hide
58875-06-2
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
indole-3-acetaldehyde + NADH
indole-3-ethanol + NAD+
show the reaction diagram
phenylacetaldehyde + NADH + H+
phenylethanol + NAD+
show the reaction diagram
-
low activity
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
indole-3-acetaldehyde + NADH
indole-3-ethanol + NAD+
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cd2+
-
complete inhibition at 2 mM
Cu2+
-
complete inhibition at 2 mM
EDTA
-
strong inhibition at 10 mM
Hg2+
-
complete inhibition at 2 mM
iodoacetic acid
-
62% inhibition at 10 mM
Ionic strength
-
slight inhibition by increasing ionic strength
-
KCN
-
complete inhibition at 1 mM
N-ethylmaleimide
-
8§% inhibition at 1 mM
NaCl
-
uncompetitive inhibition with respect to NADH, competitive inhibition with respect to indole-3-acetaldehyde
NaN3
-
slight inhibition at 10 mM
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.4 - 0.5
Indole-3-acetaldehyde
0.14 - 0.18
NADH
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.1
-
second optimum at pH 7
7
-
second optimum at pH 6.1
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
32000
-
gel filtration
33000
-
gel filtration
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE