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3beta hydroxysteroid dehydrogenase
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3-beta-hydroxy-5-ene steroid dehydrogenase
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3-beta-hydroxy-delta(5)-steroid dehydrogenase
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3beta-hydroxy steroid dehydrogenase/5-ene-4-ene isomerase
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3beta-hydroxy steroid dehydrogenase/isomerase
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3beta-hydroxy-5-ene steroid dehydrogenase
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3beta-hydroxy-5-ene-steroid dehydrogenase
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3beta-hydroxy-5-ene-steroid oxidoreductase
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3beta-hydroxy-DELTA5-C27-steroid dehydrogenase/isomerase
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3beta-hydroxy-DELTA5-C27-steroid oxidoreductase
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3beta-hydroxysteroid dehydrogenase
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3beta-hydroxysteroid dehydrogenase/isomerase
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5-ene-3-beta-hydroxysteroid dehydrogenase
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5alpha-dihydrotestosterone 3beta-hydroxysteroid dehydrogenase
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dehydrogenase, 3beta-hydroxy-DELTA5-steroid
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DELTA5-3beta-hydroxysteroid dehydrogenase
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progesterone reductase
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steroid-DELTA5-3beta-ol dehydrogenase
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(+)-gossypol
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potent inhibitor
(-)-gossypol
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potent inhibitor
4-nonylphenol
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downregulation of 3beta-hydroxysteroid dehydrogenase mRNA at all doses tested
5'-fluorosulfonylbenzoyl adenosine
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corticosterone
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0.08 mM, 50% inhibition
diethylhexyl phthalate
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downregulation of 3beta-hydroxysteroid dehydrogenase mRNA at all doses tested
diethylstilbestrol
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downregulation of 3beta-hydroxysteroid dehydrogenase mRNA at all doses tested
estradiol
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0.0005 mM, 40% inhibition, 0.001 mM, 62% inhibition
ketoconazole
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downregulation of 3beta-hydroxysteroid dehydrogenase mRNA at all doses tested
Norethisterone acetate
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octylphenol
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downregulation of 3beta-hydroxysteroid dehydrogenase mRNA at all doses tested
oestradiol
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0.00024 mM, 50% inhibition
testosterone
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0.0086 mM, 50% inhibition
monooctyltin
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0.081 mM, 50% inhibition
monooctyltin
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inhibition mechanism, overview
progesterone
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0.026 mM, 50% inhibition
progesterone
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0.025 mM, 44% inhibition, 0.05 mM, 67% inhibition
tributyltin
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0.012 mM, almost complete loss of activity
tributyltin
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complete inhibition at 0.012 mM, the inhibition mechanism is not entirely competitive, overview
trilostane
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potent inhibition
trilostane
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0.004 mM, 50% inhibition
trilostane
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0.005 mM, 56% inhibition, 0.025 mM, 90% inhibition
trilostane
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treatment does not affect transcription or translation in liver or adrenal
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Koritz, S.B.
The conversion of pregnenolone to progesterone by small particles from rat adrenal
Biochemistry
3
1098-1102
1964
Rattus norvegicus
brenda
Ishii-Ohba, H.; Inano, H.; Bunichi, T.
Testicular and adrenal 3beta-hydroxy-5-ene-steroid dehydrogenase and 5-ene-4-ene isomerase
J. Steroid Biochem.
27
775-779
1987
Rattus norvegicus
brenda
Ishii-Ohba, H.; Inano, H.; Tamaoki, B.
Purification and properties of testicular 3beta-hydroxy-5-ene-steroid dehydrogenase and 5-ene-4-ene isomerase
J. Steroid Biochem.
25
555-560
1986
Rattus norvegicus
brenda
Spona, J.
Differences in inhibition by various steroids of rat testis and Pseudomonas testosteroni DELTA5-3beta-hydroxysteroid dehydrogenase
Endocrinol. Exp.
17
107-118
1983
Comamonas testosteroni, Rattus norvegicus
brenda
Labrie, F.; Simard, J.; Luu-The, V.; Pelletier, G.; Belanger, A.; Lachance, Y.; Zhao, H.F.; Labrie, C.; Breton, N.; de Launoit, Y.; et al.
Structure and tissue-specific expression of 3beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues
J. Steroid Biochem. Mol. Biol.
41
421-435
1992
Homo sapiens, Rattus norvegicus
brenda
Lorence, M.C.; Naville, D.; Graham-Lorence, S.E.; Mack, S.O.; Murry, B.A.; Trant, J.M.; Mason, J.I.
3beta-Hydroxysteroid dehydrogenase/DELTA 5-4-isomerase expression in rat and characterization of the testis isoform
Mol. Cell. Endocrinol.
80
21-31
1991
Rattus norvegicus
brenda
Perry, J.E.; Ishii-Ohba, H.; Stalvey, J.R.
Subcellular distribution of 3beta-hydroxysteroid dehydrogenase-isomerase in bovine and murine adrenocortical tissue: species differences in the localization of activity and immunoreactivity
Steroids
56
329-336
1991
Bos taurus, Mus musculus, Rattus norvegicus
brenda
Coirini, H.; Gouezou, M.; Delespierre, B.; Liere, P.; Pianos, A.; Eychenne, B.; Schumacher, M.; Guennoun, R.
Characterization and regulation of the 3beta-hydroxysteroid dehydrogenase isomerase enzyme in the rat sciatic nerve
J. Neurochem.
84
119-126
2003
Rattus norvegicus
brenda
Coirini, H.; Gouezou, M.; Delespierre, B.; Schumacher, M.; Guennoun, R.
3 beta-hydroxysteroid dehydrogenase isomerase (3beta-HSD) activity in the rat sciatic nerve: kinetic analysis and regulation by steroids
J. Steroid Biochem. Mol. Biol.
85
89-94
2003
Rattus norvegicus
brenda
McVey, M.J.; Cooke, G.M.
Inhibition of rat testis microsomal 3b-hydroxysteroid dehydrogenase activity by tributyltin
J. Steroid Biochem. Mol. Biol.
86
99-105
2003
Rattus norvegicus
brenda
Qujeq, D.
Development of a quantitative assay method for 3 beta-hydroxy-DELTA 5-steroid dehydrogenase in the rat testis
Steroids
67
1071-1077
2002
Rattus norvegicus
brenda
Meffre, D.; Delespierre, B.; Gouezou, M.; Schumacher, M.; Stein, D.G.; Guennoun, R.
3beta-Hydroxysteroid dehydrogenase/5-ene-4-ene isomerase mRNA expression in rat brain: effect of pseudopregnancy and traumatic brain injury
J. Steroid Biochem. Mol. Biol.
104
293-300
2007
Rattus norvegicus (P22071)
brenda
Kim, H.H.; Kwak, D.H.; Yon, J.M.; Baek, I.J.; Lee, S.R.; Lee, J.E.; Nahm, S.S.; Jeong, J.H.; Lee, B.J.; Yun, Y.W.; Nam, S.Y.
Differential expression of 3beta-hydroxysteroid dehydrogenase mRNA in rat testes exposed to endocrine disruptors
J. Reprod. Dev.
53
465-471
2007
Rattus norvegicus
brenda
Malouitre, S.D.; Barker, S.; Puddefoot, J.R.; Jalili, J.; Glover, H.R.; Vinson, G.P.
Regulation of hepatic steroid receptors and enzymes by the 3beta-hydroxysteroid dehydrogenase inhibitor trilostane
J. Steroid Biochem. Mol. Biol.
101
97-105
2006
Rattus norvegicus
brenda
Szoltys, M.; Slomczynska, M.; Galas, J.; Duda, M.; Sakiewicz, A.
Expression of androgen receptor and 3beta-hydroxysteroid dehydrogenase in corpora lutea during pregnancy in the rat
Reprod. Fertil. Dev.
19
356-365
2007
Rattus norvegicus
brenda
Parthasarathy, C.; Balasubramanian, K.
Effects of corticosterone deficiency and its replacement on Leydig cell steroidogenesis
J. Cell. Biochem.
104
1671-1683
2008
Rattus norvegicus (P22071)
brenda
Hu, G.X.; Zhou, H.Y.; Li, X.W.; Chen, B.B.; Xiao, Y.C.; Lian, Q.Q.; Liang, G.; Kim, H.H.; Zheng, Z.Q.; Hardy, D.O.; Ge, R.S.
The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes
J. Steroid Biochem. Mol. Biol.
115
14-19
2009
Homo sapiens, Rattus norvegicus
brenda
Ryzhavskii, B.Y.; Zadvornaya, O.V.
3beta-hydroxysteroid dehydrogenase in the brain ependymocytes
Bull. Exp. Biol. Med.
155
113-114
2013
Rattus norvegicus
brenda