Reference on EC 1.1.1.141 - 15-hydroxyprostaglandin dehydrogenase (NAD+)

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lee, S.C.; Levine, L.
Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types
J. Biol. Chem.
250
548-552
1975
Canis lupus familiaris, Gallus gallus, Homo sapiens, Platyrrhini, Sus scrofa
Manually annotated by BRENDA team
Lee, S.C.; Pong, S.S.; Katzen, D.; Wu, K.Y.; Levine, L.
Distribution of prostaglandin E 9-ketoreductase and type I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex
Biochemistry
14
142-145
1975
Sus scrofa
Manually annotated by BRENDA team
Tombach, B.; Kusseler, R.; Schlegel, W.
Purification of human placental prostaglandin 15-hydroxydehydrogenase
J. Chromatogr.
521
231-238
1990
Homo sapiens
Manually annotated by BRENDA team
Braithwaite, S.S.; Jabarak, J.
Studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Purification and partial characterization
J. Biol. Chem.
250
2315-2318
1975
Homo sapiens
Manually annotated by BRENDA team
Jabarak, J.; Braithwaite, S.S.
Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta
Arch. Biochem. Biophys.
177
245-254
1976
Homo sapiens
Manually annotated by BRENDA team
Saeed, S.A.; Roy, A.C.
Purification of 15-hydroxy prostaglandin dehydrogenase from bovine lung
Biochem. Biophys. Res. Commun.
47
96-102
1972
Bos taurus
Manually annotated by BRENDA team
Iijima, Y.; Ueno, T.; Sasagawa, K.; Yamazaki, M.
Inhibition of 15-hydroxyprostaglandin dehydrogenase by papaverine
Biochem. Biophys. Res. Commun.
80
484-489
1978
Canis lupus familiaris, Cavia porcellus, Gallus gallus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Jung, A.; Schlegel, W.; Jackisch, R.; Friedrich, E.J.; Wendel, A.; Ruckrich, M.F.
15-Hydroxyprostaglandin dehydrogenase from human placenta. 1. Isolation and characterization
Hoppe-Seyler's Z. Physiol. Chem.
356
787-798
1975
Homo sapiens
Manually annotated by BRENDA team
Ruckrich, M.F.; Wendel, A.; Schlegel, W.; Jackisch, R.; Jung, A.
15-Hydroxyprostaglandin dehydrogenase from human placenta, II. Steady state kinetics and influence of prostaglandin F2alpha analogues
Hoppe-Seyler's Z. Physiol. Chem.
356
799-809
1975
Homo sapiens
Manually annotated by BRENDA team
Bergholte, J.M.; Okita, R.T.
Isolation and properties of lung 15-hydroxyprostaglandin dehydrogenase from pregnant rabbits
Arch. Biochem. Biophys.
245
308-315
1986
Oryctolagus cuniculus
Manually annotated by BRENDA team
Krook, M.; Marekov, L.; Jörnvall, H.
Purification and structural characterization of placental NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family
Biochemistry
29
738-743
1990
Homo sapiens
Manually annotated by BRENDA team
Jabarak, J.
Isolation and properties of an NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from human placenta
Methods Enzymol.
86
126-130
1982
Homo sapiens
Manually annotated by BRENDA team
Kung-Chao, D.T.Y.; Tai, H.H.
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from porcine kidney. II. Kinetic studies
Biochim. Biophys. Acta
614
14-24
1980
Sus scrofa
Manually annotated by BRENDA team
Mak, O.T.; Liu, Y.; Tai, H.H.
Purification and characterization of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase from porcine kidney
Biochim. Biophys. Acta
1035
190-196
1990
Sus scrofa
Manually annotated by BRENDA team
Hansen, H.S.
Inhibition by indomethacin and aspirin of 15-hydroxyprostaglandin dehydrogenase in vitro
Prostaglandins
8
95-105
1974
Bos taurus
Manually annotated by BRENDA team
Schlegel, W.; Demers, L.M.; Hildebrandt-Stark, H.E.; Behrman, H.R.; Greep, R.O.
Partial purification of human placental 15-hydroxy-prostaglandin dehydrogenase: kinetic properties
Prostaglandins
5
417-433
1974
Homo sapiens
Manually annotated by BRENDA team
Tai, H.H.
Assay of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase using (15S)-[15-3H]PGE2
Methods Enzymol.
86
131-135
1982
Sus scrofa
Manually annotated by BRENDA team
Sakuma, S.; Fujimoto, Y.; Hikita, E.; Okano, Y.; Yamamoto, I.; Fujita, T.
Effects of metal ions on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex
Prostaglandins
40
507-514
1990
Oryctolagus cuniculus
Manually annotated by BRENDA team
Treissman, D.; Smith, G.N.; Patrick, J.; Brien, J.F.
Effect of ethanol on 15-hydroxyprostaglandin dehydrogenase activity in the brain stem of the near-term fetal sheep
Dev. Pharmacol. Ther.
16
48-52
1991
Ovis aries
Manually annotated by BRENDA team
Xun, C.Q.; Ensor, C.M.; Tai, H.H.
Regulation of synthesis and activity of NAD+-dependent 15-hydroxy-prostaglandin dehydrogenase (15-PGDH) by dexamethasone and phorbol ester in human erythroleukemia (HEL) cells
Biochem. Biophys. Res. Commun.
177
1258-1265
1991
Homo sapiens
Manually annotated by BRENDA team
Jarabak, J.
Polycyclic aromatic hydrocarbon quinones may be either substrates for or irreversible inhibitors of the human placental NAD-linked 15-hydroxyprostaglandin dehydrogenase
Arch. Biochem. Biophys.
292
239-243
1992
Homo sapiens
Manually annotated by BRENDA team
Mibe, M.; Nagai, K.; Oshige, T.; Mori, N.
Endogenous inhibitors of human placental prostaglandin dehydrogenase
Prostaglandins Leukot. Essent. Fatty Acids
46
241-245
1992
Homo sapiens
Manually annotated by BRENDA team
Chavan, A.J.; Ensoe, C.M.; Wu, P.; Haley, B.E.; Tai, H.H.
Photoaffinity labeling of human placental NAD+-linked 15-hydroxyprostaglandin dehydrogenase with [alpha-32]2N3NAD+
J. Biol. Chem.
268
16437-16442
1993
Homo sapiens
Manually annotated by BRENDA team
Höhl, W.; Stahl, B.; Mundkowski, R.; Hofmann, U.; Meese, C.O.; Kuhlmann, U.; Schlegel, W.
Mass determination of 15-hydroxyprostaglandin dehydrogenase from human placenta and kinetic studies with (5Z,8E,10E,12S)-12-hydroxy-5,8,10,-heptadecatrienoic acid as substrate
Eur. J. Biochem.
214
67-73
1993
Homo sapiens
Manually annotated by BRENDA team
Sakuma, S.; Fujimoto, Y.; Nakagawa, H.; Hachiki, S.; Nishida, H.; Fujita, T.
Effect of 13-hydroperoxyoctadecadienoic acid on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex
Prostaglandins
46
157-165
1993
Oryctolagus cuniculus
Manually annotated by BRENDA team
Ensoe, C.M.; Tai, H.H.
Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
Biochim. Biophys. Acta
1208
151-156
1994
Homo sapiens
Manually annotated by BRENDA team
Okita, R.T.; Okita, J.R.
Prostaglandin-metabolizing enzymes during pregnancy: characterization of NAD+-dependent prostaglandin dehydrogenase, carbonyl reductase, and cytochrome P450-dependent prostaglandin omega-hydroxylase
CRC Crit. Rev. Biochem.
31
101-126
1996
Bos taurus, Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Tong, M.; Tai, H.H.
Induction of NAD+-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells
Biochem. Biophys. Res. Commun.
276
77-81
2000
Homo sapiens
Manually annotated by BRENDA team
Fujimori, K.; Okada, T.; Urade, Y.
Expression of NADP(+)-Dependent 15-Hydroxyprostaglandin Dehydrogenase mRNA in Monkey Ocular Tissues and Characterization of Its Recombinant Enzyme
J. Biochem.
131
383-389
2002
Macaca fascicularis
Manually annotated by BRENDA team
Tai, H.H.; Ensor, C.M.; Zhou, H.; Yan, F.
Structure and function of human NAD+-linked 15-hydroxyprostaglandin dehydrogenase
Adv. Exp. Med. Biol.
507
245-250
2002
Homo sapiens
Manually annotated by BRENDA team
Cho, H.; Tai, H.H.
Thiazolidinediones as a novel class of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
Arch. Biochem. Biophys.
405
247-251
2002
Homo sapiens
Manually annotated by BRENDA team
Cho, H.; Oliveira, M.A.; Tai, H.H.
Critical residues for the coenzyme specificity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
Arch. Biochem. Biophys.
419
139-146
2003
Homo sapiens
Manually annotated by BRENDA team
Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.
Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase
Arch. Biochem. Biophys.
433
447-453
2005
Homo sapiens
Manually annotated by BRENDA team
Tong, M.; Tai, H.H.
15-Hydroxyprostaglandin dehydrogenase can be induced by dexamethasone and other glucocorticoids at the therapeutic level in A549 human lung adenocarcinoma cells
Arch. Biochem. Biophys.
435
50-55
2005
Homo sapiens
Manually annotated by BRENDA team
Cho, H.; Tai, H.H.
Threonine 11 of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase may interact with NAD(+) during catalysis
Prostaglandins
66
505-509
2002
Homo sapiens
Manually annotated by BRENDA team
Cho, H.; Tai, H.H.
Inhibition of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by cyclooxygenase inhibitors and chemopreventive agents
Prostaglandins
67
461-465
2002
Homo sapiens
Manually annotated by BRENDA team
Otani, T.; Yamaguchi, K.; Scherl, E.; Du, B.; Tai, H.H.; Greifer, M.; Petrovic, L.; Daikoku, T.; Dey, S.K.; Subbaramaiah, K.; Dannenberg, A.J.
Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha
Am. J. Physiol.
290
G361-G368
2006
Homo sapiens
Manually annotated by BRENDA team
Tong, M.; Ding, Y.; Tai, H.H.
Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells
Biochem. Pharmacol.
72
701-709
2006
Homo sapiens
Manually annotated by BRENDA team
Hamza, A.; Cho, H.; Tai, H.H.; Zhan, C.G.
Understanding human 15-hydroxyprostaglandin dehydrogenase binding with NAD+ and PGE2 by homology modeling, docking and molecular dynamics simulation
Bioorg. Med. Chem.
13
4544-4551
2005
Homo sapiens
Manually annotated by BRENDA team
Mann, J.R.; Backlund, M.G.; Buchanan, F.G.; Daikoku, T.; Holla, V.R.; Rosenberg, D.W.; Dey, S.K.; DuBois, R.N.
Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression
Cancer Res.
66
6649-6656
2006
Homo sapiens
Manually annotated by BRENDA team
Wolf, I.; OKelly, J.; Rubinek, T.; Tong, M.; Nguyen, A.; Lin, B.T.; Tai, H.H.; Karlan, B.Y.; Koeffler, H.P.
15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer
Cancer Res.
66
7818-7823
2006
Homo sapiens
Manually annotated by BRENDA team
Ding, Y.; Tong, M.; Liu, S.; Moscow, J.A.; Tai, H.H.
NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer
Carcinogenesis
26
65-72
2005
Homo sapiens
Manually annotated by BRENDA team
Tong, M.; Ding, Y.; Tai, H.H.
Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells
Carcinogenesis
27
2170-2179
2006
Homo sapiens
Manually annotated by BRENDA team
Tai, H.H.; Cho, H.; Tong, M.; Ding, Y.
NAD+-linked 15-hydroxyprostaglandin dehydrogenase: structure and biological functions
Curr. Pharm. Des.
12
955-962
2006
Homo sapiens
Manually annotated by BRENDA team
Backlund, M.G.; Mann, J.R.; Holla, V.R.; Buchanan, F.G.; Tai, H.H.; Musiek, E.S.; Milne, G.L.; Katkuri, S.; DuBois, R.N.
15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer
J. Biol. Chem.
280
3217-3223
2005
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Giannoulias, D.; Haluska, G.J.; Gravett, M.G.; Sadowsky, D.W.; Challis, J.R.; Novy, M.J.
Localization of prostaglandin H synthase, prostaglandin dehydrogenase, corticotropin releasing hormone and glucocorticoid receptor in rhesus monkey fetal membranes with labor and in the presence of infection
Placenta
26
289-297
2005
Macaca mulatta
Manually annotated by BRENDA team
Myung, S.J.; Rerko, R.M.; Yan, M.; Platzer, P.; Guda, K.; Dotson, A.; Lawrence, E.; Dannenberg, A.J.; Lovgren, A.K.; Luo, G.; Pretlow, T.P.; Newman, R.A.; Willis, J.; Dawson, D.; Markowitz, S.D.
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis
Proc. Natl. Acad. Sci. USA
103
12098-12102
2006
Mus musculus, Mus musculus C57BL/6J
Manually annotated by BRENDA team
Quidville, V.; Segond, N.; Lausson, S.; Frenkian, M.; Cohen, R.; Jullienne, A.
15-Hydroxyprostaglandin-dehydrogenase is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a human medullary thyroid carcinoma cell line
Prostaglandins Other Lipid Mediat.
81
14-30
2006
Homo sapiens
Manually annotated by BRENDA team
Parent, M.; Madore, E.; MacLaren, L.A.; Fortier, M.A.
15-Hydroxyprostaglandin dehydrogenase in the bovine endometrium during the oestrous cycle and early pregnancy
Reproduction
131
573-582
2006
Bos taurus, Bos taurus (Q309F3)
Manually annotated by BRENDA team
Yao, B.; Xu, J.; Harris, R.C.; Zhang, M.Z.
Renal localization and regulation of 15-hydroxyprostaglandin dehydrogenase
Am. J. Physiol. Renal Physiol.
294
F433-F439
2008
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Yang, L.; Amann, J.M.; Kikuchi, T.; Porta, R.; Guix, M.; Gonzalez, A.; Park, K.H.; Billheimer, D.; Arteaga, C.L.; Tai, H.H.; DuBois, R.; Carbone, D.P.; Johnson, D.H.
Inhibition of epidermal growth factor receptor signaling elevates 15-hydroxyprostaglandin dehydrogenase in non-small-cell lung cancer
Cancer Res.
67
5587-5593
2007
Homo sapiens
Manually annotated by BRENDA team
Huang, G.; Eisenberg, R.; Yan, M.; Monti, S.; Lawrence, E.; Fu, P.; Walbroehl, J.; Loewenberg, E.; Golub, T.; Merchan, J.; Tenen, D.G.; Markowitz, S.D.; Halmos, B.
15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer
Cancer Res.
68
5040-5048
2008
Homo sapiens
Manually annotated by BRENDA team
Michelet, J.F.; Colombe, L.; Gautier, B.; Gaillard, O.; Benech, F.; Pereira, R.; Boulle, C.; Dalko-Csiba, M.; Rozot, R.; Neuwels, M.; Bernard, B.A.
Expression of NAD(+) dependent 15-hydroxyprostaglandin dehydrogenase and protection of prostaglandins in human hair follicle
Exp. Dermatol.
17
821-828
2008
Homo sapiens, Homo sapiens (P15428)
Manually annotated by BRENDA team
Chou, W.L.; Chuang, L.M.; Chou, C.C.; Wang, A.H.; Lawson, J.A.; FitzGerald, G.A.; Chang, Z.F.
Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation
J. Biol. Chem.
282
18162-18172
2007
Mus musculus
Manually annotated by BRENDA team
Pham, H.; Eibl, G.; Vincenti, R.; Chong, B.; Tai, H.H.; Slice, L.W.
15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice
Mol. Carcinog.
47
466-477
2008
Rattus norvegicus (O08699), Rattus norvegicus
Manually annotated by BRENDA team
Roizen, J.D.; Asada, M.; Tong, M.; Tai, H.H.; Muglia, L.J.
Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice
Mol. Endocrinol.
22
105-112
2008
Mus musculus
Manually annotated by BRENDA team
Hazra, S.; Batra, R.K.; Tai, H.H.; Sharma, S.; Cui, X.; Dubinett, S.M.
Pioglitazone and rosiglitazone decrease prostaglandin E2 in non-small-cell lung cancer cells by up-regulating 15-hydroxyprostaglandin dehydrogenase
Mol. Pharmacol.
71
1715-1720
2007
Homo sapiens
Manually annotated by BRENDA team
Uppal, S.; Diggle, C.P.; Carr, I.M.; Fishwick, C.W.; Ahmed, M.; Ibrahim, G.H.; Helliwell, P.S.; Latos-Biele?ska, A.; Phillips, S.E.; Markham, A.F.; Bennett, C.P.; Bonthron, D.T.
Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy
Nat. Genet.
40
789-793
2008
Homo sapiens
Manually annotated by BRENDA team
Tai, H.H.; Tong, M.; Ding, Y.
15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer
Prostaglandins Other Lipid Mediat.
83
203-208
2007
Homo sapiens
Manually annotated by BRENDA team
Rizek, R.M.; Watson, C.S.; Keating, S.; Tai, H.; Challis, J.R.; Bocking, A.D.
15-Hydroxyprostaglandin dehydrogenase protein expression in human fetal membranes with and without subclinical inflammation
Reprod. Sci.
14
260-269
2007
Homo sapiens
Manually annotated by BRENDA team
Miyaki, A.; Yang, P.; Tai, H.H.; Subbaramaiah, K.; Dannenberg, A.J.
Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes
Am. J. Physiol. Gastrointest. Liver Physiol.
297
G559-G566
2009
Homo sapiens
Manually annotated by BRENDA team
Chi, X.; Freeman, B.M.; Tong, M.; Zhao, Y.; Tai, H.H.
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells
Arch. Biochem. Biophys.
487
139-145
2009
Homo sapiens
Manually annotated by BRENDA team
Hughes, D.; Otani, T.; Yang, P.; Newman, R.A.; Yantiss, R.K.; Altorki, N.K.; Port, J.L.; Yan, M.; Markowitz, S.D.; Mazumdar, M.; Tai, H.H.; Subbaramaiah, K.; Dannenberg, A.J.
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer
Cancer Prev. Res. (Phila.)
1
241-249
2008
Homo sapiens
Manually annotated by BRENDA team
Backlund, M.G.; Mann, J.R.; Holla, V.R.; Shi, Q.; Daikoku, T.; Dey, S.K.; DuBois, R.N.
Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and Snail in colorectal cancer
Cancer Res.
68
9331-9337
2008
Homo sapiens
Manually annotated by BRENDA team
Tariq, M.; Azeem, Z.; Ali, G.; Chishti, M.S.; Ahmad, W.
Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC)
J. Med. Genet.
46
14-20
2009
Homo sapiens
Manually annotated by BRENDA team
Celis, J.E.; Gromov, P.; Cabezon, T.; Moreira, J.M.; Friis, E.; Jirstroem, K.; Llombart-Bosch, A.; Timmermans-Wielenga, V.; Rank, F.; Gromova, I.
15-prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma
Mol. Cell. Proteomics
7
1795-1809
2008
Homo sapiens (P15428)
Manually annotated by BRENDA team
Wei, C.; Zhu, P.; Shah, S.J.; Blair, I.A.
15-oxo-Eicosatetraenoic acid, a metabolite of macrophage 15-hydroxyprostaglandin dehydrogenase that inhibits endothelial cell proliferation
Mol. Pharmacol.
76
516-525
2009
Homo sapiens
Manually annotated by BRENDA team
Wu, Y.; Tai, H.H.; Cho, H.
Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors
Bioorg. Med. Chem.
18
1428-1433
2010
Homo sapiens
Manually annotated by BRENDA team
Liu, Z.; Wang, X.; Lu, Y.; Du, R.; Luo, G.; Wang, J.; Zhai, H.; Zhang, F.; Wen, Q.; Wu, K.; Fan, D.
15-Hydroxyprostaglandin dehydrogenase is a tumor suppressor of human gastric cancer
Cancer Biol. Ther.
10
780-787
2010
Homo sapiens
Manually annotated by BRENDA team
Chi, X.; Tai, H.H.
Interleukin-4 up-regulates 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in human lung cancer cells
Exp. Cell Res.
316
2251-2259
2010
Homo sapiens
Manually annotated by BRENDA team
Wu, Y.; Karna, S.; Choi, C.H.; Tong, M.; Tai, H.H.; Na, D.H.; Jang, C.H.; Cho, H.
Synthesis and biological evaluation of novel thiazolidinedione analogues as 15-hydroxyprostaglandin dehydrogenase inhibitors
J. Med. Chem.
54
5260-5264
2011
Homo sapiens
Manually annotated by BRENDA team
Thill, M.; Fischer, D.; Kelling, K.; Hoellen, F.; Dittmer, C.; Hornemann, A.; Salehin, D.; Diedrich, K.; Friedrich, M.; Becker, S.
Expression of vitamin D receptor (VDR), cyclooxygenase-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and malignant ovarian tissue and 25-hydroxycholecalciferol (25(OH2)D3) and prostaglandin E2 (PGE2) serum level in ovarian cancer
J. Steroid Biochem. Mol. Biol.
121
387-390
2010
Homo sapiens
Manually annotated by BRENDA team
Lu, D.; Han, C.; Wu, T.
15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARgamma-mediated activation of p21(WAF1/Cip1.)
Oncogene
33
1101-1112
2013
Homo sapiens
Manually annotated by BRENDA team
Niesen, F.; Schultz, L.; Jadhav, A.; Bhatia, C.; Guo, K.; Maloney, D.; Pilka, E.; Wang, M.; Oppermann, U.; Heightman, T.; Simeonov, A.
High-affinity inhibitors of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships
PLoS ONE
5
e13719
2010
Homo sapiens
Manually annotated by BRENDA team
Welsh, T.; Paul, J.; Palliser, H.K.; Tabatabaee, H.; Hirst, J.; Mesiano, S.; Zakar, T.
15-Hydroxyprostaglandin dehydrogenase expression and localization in guinea pig gestational tissues during late pregnancy and parturition
Reprod. Sci.
19
1099-1109
2012
Sus scrofa
Manually annotated by BRENDA team